Detailed information for compound 1383595

Basic information

Technical information
  • TDR Targets ID: 1383595
  • Name: 2-(3,5-dimethoxyphenyl)-6-ethyl-5-methyl-7-py rrolidin-1-ylpyrazolo[1,5-a]pyrimidine
  • MW: 366.457 | Formula: C21H26N4O2
  • H donors: 0 H acceptors: 2 LogP: 4.07 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1c(C)nc2n(c1N1CCCC1)nc(c2)c1cc(OC)cc(c1)OC
  • InChi: 1S/C21H26N4O2/c1-5-18-14(2)22-20-13-19(15-10-16(26-3)12-17(11-15)27-4)23-25(20)21(18)24-8-6-7-9-24/h10-13H,5-9H2,1-4H3
  • InChiKey: JKEPLTQSKAEDNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3,5-dimethoxyphenyl)-6-ethyl-5-methyl-7-pyrrolidin-1-yl-pyrazolo[1,5-a]pyrimidine
  • 2-(3,5-dimethoxyphenyl)-6-ethyl-5-methyl-7-1-pyrrolidinylpyrazolo[1,5-a]pyrimidine
  • ASN 08735702
  • ZINC01341129
  • 2-(3,5-Dimethoxy-phenyl)-6-ethyl-5-methyl-7-pyrrolidin-1-yl-pyrazolo[1,5-a]pyrimidine
  • MLS000035293
  • SMR000008498

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0844 0.1576 1
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Brugia malayi hypothetical protein 0.0394 0.0706 0.0702
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0098 0.0135 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.006 0.0066
Loa Loa (eye worm) TK protein kinase 0.0059 0.006 0.0055
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0083 0.0107 0.0122
Toxoplasma gondii protein kinase domain-containing protein 0.0098 0.0135 1
Echinococcus multilocularis lamin 0.0033 0.0008 0.0005
Echinococcus multilocularis FL cytokine receptor 0.0059 0.006 0.0066
Loa Loa (eye worm) TK/ABL protein kinase 0.0059 0.006 0.0055
Echinococcus multilocularis tyrosine kinase 0.0059 0.006 0.0066
Loa Loa (eye worm) TK/CSK protein kinase 0.0059 0.006 0.0055
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0059 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0394 0.0706 0.0702
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Entamoeba histolytica protein kinase, putative 0.0098 0.0135 0.0858
Toxoplasma gondii phosphatidylinositol transfer protein 0.0077 0.0095 0.7026
Loa Loa (eye worm) hypothetical protein 0.0059 0.006 0.0055
Echinococcus multilocularis protein KINase family member (kin 25) 0.0059 0.006 0.0066
Loa Loa (eye worm) protein kinase domain-containing protein 0.0059 0.006 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Echinococcus granulosus activin receptor type 0.008 0.01 0.0114
Loa Loa (eye worm) hypothetical protein 0.01 0.0139 0.0135
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Brugia malayi regulator of G-protein signaling egl-10 0.0844 0.1576 0.1572
Loa Loa (eye worm) TK/INSR protein kinase 0.0059 0.006 0.0055
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Echinococcus multilocularis insulin receptor 0.0059 0.006 0.0066
Echinococcus multilocularis pleckstrin y domain containing family A 0.0077 0.0095 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0077 0.0095 0.0108
Trypanosoma cruzi NIMA-related kinase, putative 0.0098 0.0135 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0059 0.006 0.0066
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0139 0.0161
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0107 0.0558
Loa Loa (eye worm) hypothetical protein 0.0059 0.006 0.0055
Echinococcus multilocularis raf serine:threonine protein kinase 0.0059 0.006 0.0066
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0059 0.006 0.0066
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0059 0.006 0.0256
Loa Loa (eye worm) Plekhf2 protein 0.0077 0.0095 0.009
Brugia malayi PH domain containing protein 0.0077 0.0095 0.009
Loa Loa (eye worm) SRC-1 0.0059 0.006 0.0055
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0172 0.0279 0.0274
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0077 0.0095 0.0108
Onchocerca volvulus 0.0059 0.006 0.0318
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0077 0.0095 0.009
Echinococcus multilocularis tyrosine kinase 0.0059 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0059 0.006 0.0055
Echinococcus multilocularis regulator of G protein signaling 3 0.0844 0.1576 0.1878
Echinococcus multilocularis neuropeptide s receptor 0.056 0.1028 0.1224
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Schistosoma mansoni hypothetical protein 0.0077 0.0095 0.009
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Entamoeba histolytica tyrosin kinase, putative 0.0059 0.006 0.0379
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.006 0.0066
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0139 0.0161
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0077 0.0095 0.7026
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0098 0.0135 1
Echinococcus multilocularis axis inhibition protein axin 0.0844 0.1576 0.1878
Trichomonas vaginalis conserved hypothetical protein 0.0844 0.1576 1
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0059 0.006 0.0066
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0059 0.006 0.0055
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus granulosus Pleckstrin y 0.0077 0.0095 0.0108
Schistosoma mansoni protein kinase 0.0059 0.006 0.0055
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0077 0.0095 0.009
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0172 0.0279 0.1663
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Loa Loa (eye worm) PXA domain-containing protein 0.0844 0.1576 0.1572
Trypanosoma cruzi hypothetical protein 0.0077 0.0095 0.4676
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0059 0.006 0.4414
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.008 0.01 0.5324
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Echinococcus multilocularis tyrosine protein kinase Abl 0.0059 0.006 0.0066
Echinococcus granulosus neuropeptide s receptor 0.056 0.1028 0.1224
Echinococcus multilocularis musashi 0.0033 0.0008 0.0005
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0077 0.0095 0.0108
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0059 0.006 0.0379
Echinococcus granulosus neuropeptide receptor A26 0.056 0.1028 0.1224
Onchocerca volvulus 0.0059 0.006 0.0318
Echinococcus granulosus expressed protein 0.0844 0.1576 0.1878
Trichomonas vaginalis conserved hypothetical protein 0.0844 0.1576 1
Schistosoma mansoni hypothetical protein 0.0394 0.0706 0.0702
Loa Loa (eye worm) hypothetical protein 0.0114 0.0166 0.0162
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0098 0.0135 1
Schistosoma mansoni regulator of G protein signaling 0.0844 0.1576 0.1572
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0107 0.0558
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0077 0.0095 0.0108
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0077 0.0095 0.0603
Schistosoma mansoni serine/threonine protein kinase 0.3989 0.7652 0.7651
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0077 0.0095 0.0108
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0844 0.1576 1
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0098 0.0135 1
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Loa Loa (eye worm) hypothetical protein 0.0119 0.0176 0.0172
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0093 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0844 0.1576 1
Echinococcus multilocularis pdz domain containing protein 0.0077 0.0095 0.0108
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0172 0.0279 0.1663
Echinococcus multilocularis tyrosine protein kinase csk 0.0059 0.006 0.0066
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0083 0.0107 0.0677
Onchocerca volvulus 0.0059 0.006 0.0318
Entamoeba histolytica hypothetical protein 0.0059 0.006 0.0379
Loa Loa (eye worm) TK protein kinase 0.0059 0.006 0.0055
Echinococcus multilocularis Immunoglobulin 0.0114 0.0166 0.0193
Brugia malayi SH2 domain containing protein 0.0059 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0036 0.0015 0.001
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0059 0.006 0.0055
Brugia malayi Tyrosine-protein kinase PR2 0.0059 0.006 0.0055
Entamoeba histolytica protein kinase, putative 0.0098 0.0135 0.0858
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Loa Loa (eye worm) hypothetical protein 0.0928 0.1738 0.1734
Echinococcus multilocularis oxysterol binding protein 9 0.0077 0.0095 0.0108
Loa Loa (eye worm) RGC/RGC protein kinase 0.0059 0.006 0.0055
Trichomonas vaginalis protein kinase atn1, putative 0.0059 0.006 0.0256
Trichomonas vaginalis centaurin/arf, putative 0.0077 0.0095 0.0483
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0077 0.0095 0.7026
Echinococcus multilocularis transfer RNA-Thr 0.0059 0.006 0.0066
Loa Loa (eye worm) sema domain-containing protein 0.0394 0.0706 0.0702
Echinococcus multilocularis tyrosine protein kinase csk 0.0059 0.006 0.0066
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0093 0.0089
Plasmodium falciparum tyrosine kinase-like protein 0.0059 0.006 0.4414
Brugia malayi PH domain containing protein 0.0077 0.0095 0.009
Echinococcus multilocularis Regulator of G protein signaling 20 0.0844 0.1576 0.1878
Entamoeba histolytica serine/threonine kinase, putative 0.0059 0.006 0.0379
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0059 0.006 0.0055
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0093 0.0089
Echinococcus granulosus neuroglian 0.0114 0.0166 0.0193
Loa Loa (eye worm) serine/threonine protein kinase 0.0059 0.006 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.006 0.0055
Schistosoma mansoni protein kinase 0.008 0.01 0.0095
Brugia malayi Protein kinase domain containing protein 0.0098 0.0135 0.0131
Loa Loa (eye worm) RGC/RGC protein kinase 0.0059 0.006 0.0055
Trypanosoma brucei rac serine-threonine kinase, putative 0.0098 0.0135 1
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0077 0.0095 0.0603
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Entamoeba histolytica serine/threonine kinase, putative 0.0059 0.006 0.0379
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Loa Loa (eye worm) hypothetical protein 0.0119 0.0176 0.0172
Loa Loa (eye worm) TK protein kinase 0.0059 0.006 0.0055
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus granulosus Oxysterol binding protein 11 0.0077 0.0095 0.0108
Echinococcus multilocularis protein tyrosine kinase 0.0059 0.006 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0059 0.006 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Echinococcus granulosus protein kinase 0.0059 0.006 0.0066
Brugia malayi hypothetical protein 0.0844 0.1576 0.1572
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0077 0.0095 0.0108
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0077 0.0095 0.0483
Onchocerca volvulus 0.0059 0.006 0.0318
Brugia malayi Sema domain containing protein 0.0394 0.0706 0.0702
Brugia malayi Regulator of G protein signaling domain containing protein 0.0844 0.1576 0.1572
Entamoeba histolytica hypothetical protein 0.0059 0.006 0.0379
Loa Loa (eye worm) RGS-3 protein 0.0844 0.1576 0.1572
Echinococcus granulosus tyrosine protein kinase 0.0059 0.006 0.0066
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0077 0.0095 0.0483
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0059 0.006 0.0055
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0059 0.006 0.0066
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Toxoplasma gondii STE kinase 0.0059 0.006 0.4414
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Echinococcus granulosus axis inhibition protein axin 0.0844 0.1576 0.1878
Leishmania major hypothetical protein, conserved 0.0077 0.0095 0.7026
Loa Loa (eye worm) hypothetical protein 0.0059 0.006 0.0055
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0172 0.0279 0.1663
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Entamoeba histolytica tyrosin kinase, putative 0.0059 0.006 0.0379
Trypanosoma brucei PH domain containing protein, putative 0.0077 0.0095 0.7026
Loa Loa (eye worm) TK protein kinase 0.0059 0.006 0.0055
Brugia malayi A-kinase anchor protein 10, precursor 0.0844 0.1576 0.1572
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0077 0.0095 0.7026
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Brugia malayi plexin A 0.11 0.2071 0.2067
Schistosoma mansoni hypothetical protein 0.0172 0.0279 0.0274
Echinococcus granulosus serine/threonine protein kinase 0.0098 0.0135 0.0156
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Loa Loa (eye worm) hypothetical protein 0.0119 0.0176 0.0172
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0077 0.0095 0.0108
Schistosoma mansoni regulator of G protein signaling 0.0844 0.1576 0.1572
Echinococcus granulosus tar DNA binding protein 0.0076 0.0093 0.0106
Brugia malayi serine/threonine-protein kinase 6 0.0083 0.0107 0.0102
Trichomonas vaginalis centaurin alpha, putative 0.0077 0.0095 0.0483
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0077 0.0095 0.0603
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0008 0.0004
Echinococcus granulosus G protein coupled receptor kinase 1 0.3145 0.6022 0.7194
Echinococcus multilocularis regulator of G protein signaling 7 0.0844 0.1576 0.1878
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0059 0.006 0.0379
Loa Loa (eye worm) RGC/RGC protein kinase 0.0059 0.006 0.0055
Schistosoma mansoni vav2 0.0077 0.0095 0.009
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0059 0.006 0.0318
Echinococcus multilocularis tyrosine protein kinase csk 0.0059 0.006 0.0066
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0139 0.0135
Loa Loa (eye worm) hypothetical protein 0.0059 0.006 0.0055
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Echinococcus granulosus intermediate filament protein 0.0033 0.0008 0.0005
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.006 0.0066
Brugia malayi IPT/TIG domain containing protein 0.0172 0.0279 0.0274
Entamoeba histolytica serine/threonine kinase, putative 0.0059 0.006 0.0379
Echinococcus multilocularis activated cdc42 kinase 1 0.0059 0.006 0.0066
Entamoeba histolytica hypothetical protein 0.0059 0.006 0.0379
Echinococcus multilocularis neuropeptide receptor A26 0.056 0.1028 0.1224
Onchocerca volvulus 0.0077 0.0095 0.0522
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0059 0.006 0.0066
Trichomonas vaginalis STE family protein kinase 0.0059 0.006 0.0256
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0098 0.0135 1
Echinococcus granulosus DCC interacting protein 13 beta 0.0077 0.0095 0.0108
Entamoeba histolytica cysteine surface protein, putative 0.0059 0.006 0.0379
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus granulosus tyrosine kinase 0.0059 0.006 0.0066
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Schistosoma mansoni dynamin 0.0077 0.0095 0.009
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Echinococcus granulosus lamin dm0 0.0033 0.0008 0.0005
Echinococcus granulosus calcium dependent secretion activator 1 0.0077 0.0095 0.0108
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.008 0.01 0.5324
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0077 0.0095 0.0108
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0025 0.002
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0059 0.006 0.0055
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Schistosoma mansoni myotubularin-related protein 0.0077 0.0095 0.009
Echinococcus granulosus pleckstrin y domain containing family A 0.0077 0.0095 0.0108
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0059 0.006 0.0066
Echinococcus granulosus dynamin 1 0.0077 0.0095 0.0108
Loa Loa (eye worm) hypothetical protein 0.0394 0.0706 0.0702
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0077 0.0095 0.0108
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0077 0.0095 0.009
Loa Loa (eye worm) hypothetical protein 0.0059 0.006 0.0055
Loa Loa (eye worm) TK/Met protein kinase 0.0059 0.006 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0077 0.0095 0.0108
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0059 0.006 0.0379
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Echinococcus multilocularis protein kinase 0.0059 0.006 0.0066
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0059 0.006 0.0066
Echinococcus multilocularis Pleckstrin y 0.0077 0.0095 0.0108
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0098 0.0135 1
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0098 0.0135 1
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0098 0.0135 1
Echinococcus granulosus GRB2 associated binding protein 3 0.0077 0.0095 0.0108
Echinococcus granulosus oxysterol binding protein 9 0.0077 0.0095 0.0108
Loa Loa (eye worm) hypothetical protein 0.0844 0.1576 0.1572
Echinococcus multilocularis semaphorin 5B 0.0394 0.0706 0.0838
Schistosoma mansoni hypothetical protein 0.0077 0.0095 0.009
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0077 0.0095 0.4676
Schistosoma mansoni regulator of G protein signaling 0.0844 0.1576 0.1572
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0279 0.1663
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0059 0.006 0.0066
Echinococcus granulosus protein tyrosine kinase 0.0059 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0844 0.1576 0.1572
Onchocerca volvulus 0.0059 0.006 0.0318
Echinococcus granulosus axis inhibition protein axin 0.0844 0.1576 0.1878
Loa Loa (eye worm) hypothetical protein 0.0394 0.0706 0.0702
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Echinococcus multilocularis regulator of G protein signaling 3 0.0844 0.1576 0.1878
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.006 0.0256
Entamoeba histolytica hypothetical protein 0.0059 0.006 0.0379
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0077 0.0095 0.0108
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0064 0.007 0.0078
Brugia malayi serine/threonine protein kinase 6 0.0083 0.0107 0.0102
Onchocerca volvulus 0.0077 0.0095 0.0522
Brugia malayi PH domain containing protein 0.0077 0.0095 0.009
Entamoeba histolytica hypothetical protein 0.0059 0.006 0.0379
Loa Loa (eye worm) TK/ACK protein kinase 0.0059 0.006 0.0055
Echinococcus granulosus aurora kinase A 0.0083 0.0107 0.0122
Brugia malayi PH domain containing protein 0.0077 0.0095 0.009
Loa Loa (eye worm) hypothetical protein 0.0844 0.1576 0.1572
Leishmania major protein kinase, putative 0.008 0.01 0.7388
Trypanosoma brucei aurora B kinase 0.0083 0.0107 0.7884
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Echinococcus granulosus Pleckstrin y 0.0077 0.0095 0.0108
Entamoeba histolytica PH domain containing protein kinase, putative 0.0098 0.0135 0.0858
Schistosoma mansoni protein kinase 0.0059 0.006 0.0055
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0172 0.0279 0.1663
Echinococcus granulosus transcription factor collier 0.0172 0.0279 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Schistosoma mansoni axis inhibition protein axin 0.0844 0.1576 0.1572
Echinococcus multilocularis G protein coupled receptor kinase 1 0.3145 0.6022 0.7194
Echinococcus multilocularis hypothetical protein 0.0394 0.0706 0.0838
Loa Loa (eye worm) TK/EPH protein kinase 0.0059 0.006 0.0055
Entamoeba histolytica hypothetical protein, conserved 0.0059 0.006 0.0379
Schistosoma mansoni semaphorin 5-related 0.0394 0.0706 0.0702
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0114 0.0166 0.0162
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Entamoeba histolytica hypothetical protein 0.0098 0.0135 0.0858
Echinococcus granulosus oxysterol binding protein 3 0.0077 0.0095 0.0108
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0279 0.1663
Echinococcus granulosus raf serine:threonine protein kinase 0.0059 0.006 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Entamoeba histolytica PH domain containing protein kinase, putative 0.0098 0.0135 0.0858
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Schistosoma mansoni serine/threonine protein kinase 0.5204 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0059 0.006 0.0055
Brugia malayi Cadps2 protein 0.0077 0.0095 0.009
Schistosoma mansoni protein tyrosine kinase 0.0059 0.006 0.0055
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.006 0.0256
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0059 0.006 0.0055
Brugia malayi Regulator of G protein signaling domain containing protein 0.0844 0.1576 0.1572
Mycobacterium leprae conserved hypothetical protein 0.0028 0 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0059 0.006 0.0256
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0059 0.006 0.0379
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Entamoeba histolytica hypothetical protein 0.0098 0.0135 0.0858
Loa Loa (eye worm) hypothetical protein 0.0172 0.0279 0.0274
Schistosoma mansoni protein kinase 0.0059 0.006 0.0055
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0077 0.0095 0.009
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0059 0.006 0.0256
Schistosoma mansoni rho gtpase activating protein 0.0077 0.0095 0.009
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0059 0.006 0.0066
Echinococcus multilocularis cytohesin 1 0.0077 0.0095 0.0108
Echinococcus multilocularis aurora kinase A 0.0083 0.0107 0.0122
Entamoeba histolytica hypothetical protein 0.0059 0.006 0.0379
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0059 0.006 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Schistosoma mansoni dynamin 0.0077 0.0095 0.009
Echinococcus multilocularis Immunoglobulin 0.0114 0.0166 0.0193
Echinococcus granulosus Immunoglobulin 0.0114 0.0166 0.0193
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0025 0.0024
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Onchocerca volvulus 0.0077 0.0095 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Entamoeba histolytica receptor protein kinase, putative 0.0059 0.006 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0844 0.1576 0.1572
Echinococcus granulosus tyrosine kinase 0.0059 0.006 0.0066
Echinococcus multilocularis Ras associated and pleckstrin y 0.0077 0.0095 0.0108
Schistosoma mansoni nephrin 0.0119 0.0176 0.0172
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0077 0.0095 0.0522
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Loa Loa (eye worm) TK protein kinase 0.0059 0.006 0.0055
Entamoeba histolytica protein kinase domain containing protein 0.0232 0.0393 0.2493
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0107 0.0558
Brugia malayi probable spectrin beta chain 0.0077 0.0095 0.009
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0098 0.0135 0.0742
Entamoeba histolytica protein kinase, putative 0.0098 0.0135 0.0858
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Echinococcus granulosus oxysterol binding protein 1 0.0077 0.0095 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.3989 0.7652 0.7651
Echinococcus multilocularis roundabout 2 0.0119 0.0176 0.0205
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0059 0.006 0.0055
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Trypanosoma cruzi PH domain containing protein, putative 0.0077 0.0095 0.4676
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Brugia malayi SH2 domain containing protein 0.0059 0.006 0.0055
Loa Loa (eye worm) AUR protein kinase 0.0083 0.0107 0.0102
Brugia malayi PH domain containing protein 0.0077 0.0095 0.009
Echinococcus multilocularis expressed protein 0.0844 0.1576 0.1878
Brugia malayi PXA domain containing protein 0.0844 0.1576 0.1572
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0059 0.006 0.4414
Echinococcus granulosus pdz domain containing protein 0.0077 0.0095 0.0108
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0093 0.0089
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0077 0.0095 0.0603
Loa Loa (eye worm) RNA binding protein 0.0076 0.0093 0.0089
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0025 0.002
Echinococcus granulosus epidermal growth factor receptor 0.0059 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Loa Loa (eye worm) hypothetical protein 0.0844 0.1576 0.1572
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0077 0.0095 0.0603
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0059 0.006 0.0379
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0077 0.0095 0.0603
Brugia malayi TBC domain containing protein 0.0077 0.0095 0.009
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0059 0.006 0.0379
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0093 0.0106
Echinococcus granulosus semaphorin 5B 0.0394 0.0706 0.0838
Toxoplasma gondii Oxysterol-binding protein 0.0077 0.0095 0.7026
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Brugia malayi PH domain containing protein 0.0077 0.0095 0.009
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Echinococcus multilocularis activin receptor type 0.008 0.01 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Echinococcus multilocularis neuroglian 0.0114 0.0166 0.0193
Entamoeba histolytica serine/threonine kinase, putative 0.0059 0.006 0.0379
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Brugia malayi Dynamin 0.0077 0.0095 0.009
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Entamoeba histolytica ankyrin repeat protein 0.0059 0.006 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.006 0.0256
Trichomonas vaginalis hypothetical protein 0.0077 0.0095 0.0483
Echinococcus multilocularis Pleckstrin y 0.0077 0.0095 0.0108
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0093 0.0089
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0059 0.006 0.0055
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0059 0.006 0.0055
Plasmodium vivax tyrosine kinase-like protein, putative 0.0059 0.006 0.4414
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0098 0.0135 1
Brugia malayi protein-tyrosine kinase 0.0059 0.006 0.0055
Onchocerca volvulus outspread protein homolog 0.0077 0.0095 0.0522
Echinococcus multilocularis plexin a4 0.11 0.2071 0.247
Echinococcus multilocularis heat shock protein 70 0.0059 0.006 0.0066
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.008 0.01 0.7388
Loa Loa (eye worm) hypothetical protein 0.0394 0.0706 0.0702
Schistosoma mansoni centaurin alpha 0.0077 0.0095 0.009
Entamoeba histolytica serine/threonine kinase, putative 0.0059 0.006 0.0379
Echinococcus multilocularis c src tyrosine kinase 0.0059 0.006 0.0066
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.436 0.837 0.8369
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0077 0.0095 0.0603
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0059 0.006 0.0066
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Brugia malayi bone morphogenetic protein type 1 receptor 0.0059 0.006 0.0055
Entamoeba histolytica PH domain containing protein kinase, putative 0.0098 0.0135 0.0858
Onchocerca volvulus 0.0059 0.006 0.0318
Leishmania major serine/threonine-protein kinase a, putative 0.0098 0.0135 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0059 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0172 0.0279 0.0274
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0059 0.006 0.0066
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Schistosoma mansoni protein kinase 0.0059 0.006 0.0055
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0059 0.006 0.0066
Brugia malayi hypothetical protein 0.0059 0.006 0.0055
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0059 0.006 0.0055
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0114 0.0166 0.0193
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Schistosoma mansoni cell adhesion molecule 0.0119 0.0176 0.0172
Schistosoma mansoni fibrocystin l 0.0172 0.0279 0.0274
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0059 0.006 0.0055
Trypanosoma cruzi PH domain containing protein, putative 0.0077 0.0095 0.4676
Brugia malayi hypothetical protein 0.0394 0.0706 0.0702
Echinococcus granulosus regulator of G protein signaling 7 0.0844 0.1576 0.1878
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Echinococcus multilocularis dynamin 1 0.0077 0.0095 0.0108
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0098 0.0135 1
Entamoeba histolytica hypothetical protein 0.0059 0.006 0.0379
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0059 0.006 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0279 0.1663
Echinococcus granulosus tyrosine protein kinase ABL1 0.0059 0.006 0.0066
Onchocerca volvulus Tyrosine kinase homolog 0.0059 0.006 0.0318
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0077 0.0095 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0279 0.1663
Echinococcus granulosus tyrosine protein kinase HCK 0.0059 0.006 0.0066
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Echinococcus granulosus beta 1 syntrophin 0.0077 0.0095 0.0108
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0077 0.0095 0.009
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Entamoeba histolytica hypothetical protein 0.0077 0.0095 0.0603
Loa Loa (eye worm) hypothetical protein 0.0059 0.006 0.0055
Leishmania major protein kinase, putative 0.0083 0.0107 0.7884
Trypanosoma cruzi Protein kinase B 0.0098 0.0135 1
Brugia malayi Fibronectin type III domain containing protein 0.0119 0.0176 0.0172
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0114 0.0166 0.0162
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0059 0.006 0.0055
Echinococcus multilocularis oxysterol binding protein 1 0.0077 0.0095 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Echinococcus granulosus Rho GTPase activating protein 24 0.0077 0.0095 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.006 0.0256
Brugia malayi hypothetical protein 0.0077 0.0095 0.009
Toxoplasma gondii AtPH1 family protein 0.0077 0.0095 0.7026
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0077 0.0095 0.009
Entamoeba histolytica hypothetical protein 0.0059 0.006 0.0379
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Loa Loa (eye worm) hypothetical protein 0.0534 0.0978 0.0973
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0077 0.0095 0.0603
Entamoeba histolytica hypothetical protein 0.0172 0.0279 0.1768
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Schistosoma mansoni regulator of G protein signaling 0.0844 0.1576 0.1572
Leishmania major protein kinase, putative 0.0059 0.006 0.4414
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0283 0.0491 0.0487
Entamoeba histolytica hypothetical protein 0.0059 0.006 0.0379
Echinococcus granulosus roundabout 2 0.0119 0.0176 0.0205
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus multilocularis actin binding protein anillin 0.0077 0.0095 0.0108
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Echinococcus granulosus kinase suppressor of Ras 1 0.0059 0.006 0.0066
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus multilocularis myotubularin protein 13 0.0077 0.0095 0.0108
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0077 0.0095 0.009
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0059 0.006 0.0066
Entamoeba histolytica hypothetical protein 0.0077 0.0095 0.0603
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Echinococcus multilocularis lamin dm0 0.0033 0.0008 0.0005
Trichomonas vaginalis centaurin/arf, putative 0.0077 0.0095 0.0483
Plasmodium vivax PH domain containing protein 0.0077 0.0095 0.7026
Echinococcus multilocularis kinase suppressor of Ras 1 0.0059 0.006 0.0066
Loa Loa (eye worm) TK/RYK protein kinase 0.0059 0.006 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Trypanosoma cruzi aurora B kinase, putative 0.0083 0.0107 0.6211
Echinococcus multilocularis dual specificity testis specific protein kinase 0.008 0.01 0.0114
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus granulosus retinal guanylyl cyclase 2 0.0059 0.006 0.0066
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Onchocerca volvulus 0.0077 0.0095 0.0522
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0844 0.1576 0.1572
Loa Loa (eye worm) hypothetical protein 0.0059 0.006 0.0055
Echinococcus granulosus c src tyrosine kinase 0.0059 0.006 0.0066
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0059 0.006 0.0055
Loa Loa (eye worm) TK protein kinase 0.0059 0.006 0.0055
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0844 0.1576 0.1878
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0059 0.006 0.0066
Brugia malayi Variant SH3 domain containing protein 0.0077 0.0095 0.009
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Echinococcus multilocularis regulator of G protein signaling 0.0844 0.1576 0.1878
Plasmodium falciparum tyrosine kinase-like protein 0.0059 0.006 0.4414
Brugia malayi DNA-binding protein LAG-1 0.0172 0.0279 0.0274
Loa Loa (eye worm) AUR protein kinase 0.0083 0.0107 0.0102
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0077 0.0095 0.0603
Brugia malayi intermediate filament protein 0.0033 0.0008 0.0004
Entamoeba histolytica tyrosin kinase, putative 0.0232 0.0393 0.2493
Schistosoma mansoni z-protein (S1r protein) 0.0844 0.1576 0.1572
Echinococcus multilocularis integrin linked protein kinase 0.0059 0.006 0.0066
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0077 0.0095 0.009
Trichomonas vaginalis protein tyrosine kinase, putative 0.0059 0.006 0.0256
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0077 0.0095 0.0108
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Entamoeba histolytica hypothetical protein 0.0844 0.1576 1
Brugia malayi hypothetical protein 0.0059 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0844 0.1576 0.1572
Trichomonas vaginalis kinesin light chain, putative 0.0077 0.0095 0.0483
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Brugia malayi Pleckstrin Homology Domain 0.0077 0.0095 0.009
Echinococcus granulosus tyrosine protein kinase shark 0.0059 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0114 0.0166 0.0162
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0059 0.006 0.0066
Trichomonas vaginalis protein transport protein sec7, putative 0.0077 0.0095 0.0483
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Entamoeba histolytica cell surface protease gp63, putative 0.0172 0.0279 0.1768
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0059 0.006 0.0066
Plasmodium falciparum protein kinase, putative 0.0059 0.006 0.4414
Echinococcus multilocularis tyrosine protein kinase Srms 0.0059 0.006 0.0066
Entamoeba histolytica protein kinase, putative 0.0083 0.0107 0.0677
Entamoeba histolytica protein kinase domain containing protein 0.0083 0.0107 0.0677
Echinococcus granulosus defective proboscis extension response 0.0114 0.0166 0.0193
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0059 0.006 0.0379
Trichomonas vaginalis protein transport protein sec7, putative 0.0077 0.0095 0.0483
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Brugia malayi Raf kinase 0.0059 0.006 0.0055
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Brugia malayi Guanylyl cyclase protein 23 0.0059 0.006 0.0055
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0077 0.0095 0.0483
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0032 0.0028
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0003
Onchocerca volvulus Protein melted homolog 0.0077 0.0095 0.0522
Echinococcus multilocularis Pleckstrin y 0.0077 0.0095 0.0108
Entamoeba histolytica hypothetical protein 0.0077 0.0095 0.0603
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0077 0.0095 0.009
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Loa Loa (eye worm) hypothetical protein 0.0172 0.0279 0.0274
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0098 0.0135 1
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Schistosoma mansoni zinc finger protein 0.0077 0.0095 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0059 0.006 0.0066
Onchocerca volvulus 0.0059 0.006 0.0318
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0059 0.006 0.0066
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Echinococcus multilocularis regulator of G protein signaling 7 0.0844 0.1576 0.1878
Entamoeba histolytica p21-activated kinase 0.0098 0.0135 0.0858
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0059 0.006 0.0066
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.006 0.0055
Echinococcus multilocularis beta adrenergic receptor kinase 0.3989 0.7652 0.9143
Brugia malayi Sema domain containing protein 0.0394 0.0706 0.0702
Schistosoma mansoni serine/threonine-protein kinase 0.0098 0.0135 0.0131
Schistosoma mansoni lamin 0.0033 0.0008 0.0004
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0844 0.1576 0.1878
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Entamoeba histolytica PH domain containing protein 0.0077 0.0095 0.0603
Echinococcus multilocularis rac serine:threonine kinase 0.0098 0.0135 0.0156
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0394 0.0706 0.0702
Echinococcus granulosus plexin a4 0.11 0.2071 0.247
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0059 0.006 0.0379
Entamoeba histolytica hypothetical protein 0.0172 0.0279 0.1768
Schistosoma mansoni goodpasture antigen-binding protein 0.0077 0.0095 0.009
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0059 0.006 0.0066
Echinococcus multilocularis oxysterol binding protein 3 0.0077 0.0095 0.0108
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0059 0.006 0.0379
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Echinococcus granulosus beta-adrenergic receptor kinase 0.3989 0.7652 0.9143
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Echinococcus multilocularis DCC interacting protein 13 beta 0.0077 0.0095 0.0108
Schistosoma mansoni growth factor receptor-bound protein 0.0077 0.0095 0.009
Entamoeba histolytica protein kinase domain containing protein 0.008 0.01 0.0634
Loa Loa (eye worm) sema domain-containing protein 0.0394 0.0706 0.0702
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0844 0.1576 1
Echinococcus granulosus twitchin 0.0135 0.0207 0.0242
Echinococcus multilocularis Rho GTPase activating protein 24 0.0077 0.0095 0.0108
Echinococcus granulosus retinal guanylyl cyclase 2 0.0059 0.006 0.0066
Echinococcus multilocularis Oxysterol binding protein 11 0.0077 0.0095 0.0108
Echinococcus granulosus activated cdc42 kinase 1 0.0059 0.006 0.0066
Onchocerca volvulus 0.0036 0.0014 0.0057
Brugia malayi Tyrosine-protein kinase abl-1 0.0059 0.006 0.0055
Entamoeba histolytica hypothetical protein 0.0844 0.1576 1
Trypanosoma cruzi hypothetical protein 0.0077 0.0095 0.4676
Leishmania major hypothetical protein, conserved 0.0059 0.006 0.4414
Trichomonas vaginalis centaurin gamma, putative 0.0077 0.0095 0.0483
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Schistosoma mansoni serine/threonine RGC 0.0059 0.006 0.0055
Schistosoma mansoni serine/threonine-protein kinase 0.0098 0.0135 0.0131
Echinococcus granulosus semaphorin 1A 0.0394 0.0706 0.0838
Loa Loa (eye worm) TK protein kinase 0.0059 0.006 0.0055
Echinococcus multilocularis axis inhibition protein axin 0.0844 0.1576 0.1878
Echinococcus granulosus retinal guanylyl cyclase 2 0.0059 0.006 0.0066
Onchocerca volvulus 0.0077 0.0095 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0279 0.1663
Echinococcus granulosus integrin linked protein kinase 0.0059 0.006 0.0066
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Loa Loa (eye worm) plexin A 0.11 0.2071 0.2067
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0059 0.006 0.0379
Entamoeba histolytica PH domain containing protein kinase, putative 0.0098 0.0135 0.0858
Echinococcus granulosus cytohesin 1 0.0077 0.0095 0.0108
Echinococcus granulosus ephrin type A receptor 4 A 0.0059 0.006 0.0066
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Trypanosoma cruzi NIMA-related kinase, putative 0.0098 0.0135 1
Entamoeba histolytica hypothetical protein 0.0172 0.0279 0.1768
Loa Loa (eye worm) TK protein kinase 0.0059 0.006 0.0055
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0059 0.006 0.0379
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0 0.5
Brugia malayi regulator of G-protein signaling rgs-7 0.0844 0.1576 0.1572
Schistosoma mansoni hypothetical protein 0.0077 0.0095 0.009
Echinococcus multilocularis protein kinase 0.0059 0.006 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.006 0.0256
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Trichomonas vaginalis TK family protein kinase 0.0059 0.006 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.006 0.0256
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0098 0.0135 1
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus granulosus exocyst complex component 2 0.0172 0.0279 0.0328
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Trypanosoma brucei protein kinase, putative 0.008 0.01 0.7388
Trichomonas vaginalis conserved hypothetical protein 0.0844 0.1576 1
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Entamoeba histolytica PH domain containing protein 0.0077 0.0095 0.0603
Schistosoma mansoni protein kinase 0.0059 0.006 0.0055
Schistosoma mansoni oxysterol-binding protein 1 0.0077 0.0095 0.009
Brugia malayi Oxysterol binding protein 0.0077 0.0095 0.009
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0059 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0095 0.7026
Echinococcus multilocularis receptor type guanylyl cyclase 0.0059 0.006 0.0066
Schistosoma mansoni hypothetical protein 0.0059 0.006 0.0055
Loa Loa (eye worm) TK protein kinase 0.0059 0.006 0.0055
Brugia malayi Probable exocyst complex component Sec5 0.0172 0.0279 0.0274
Entamoeba histolytica protein kinase, putative 0.0098 0.0135 0.0858
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0 0.5
Leishmania major folate/biopterin transporter, putative 0.0098 0.0135 1
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0107 0.0102
Schistosoma mansoni protein kinase 0.0059 0.006 0.0055
Schistosoma mansoni axis inhibition protein axin 0.0844 0.1576 0.1572
Brugia malayi Immunoglobulin I-set domain containing protein 0.0173 0.0281 0.0276
Plasmodium falciparum calcium-dependent protein kinase 7 0.0098 0.0135 1
Brugia malayi Plexin repeat family protein 0.0928 0.1738 0.1734
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Entamoeba histolytica PH domain containing protein 0.0077 0.0095 0.0603
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0059 0.006 0.0066
Schistosoma mansoni tyrosine protein kinase 0.0059 0.006 0.0055
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.436 0.837 0.8369
Plasmodium falciparum protein kinase, putative 0.0059 0.006 0.4414
Onchocerca volvulus Putative zinc finger protein 0.0077 0.0095 0.0522
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0098 0.0135 1
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Entamoeba histolytica hypothetical protein 0.0077 0.0095 0.0603
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0114 0.0166 0.0162
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0077 0.0095 0.7026
Brugia malayi ephrin receptor 1 precursor 0.0059 0.006 0.0055
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0059 0.006 0.0256
Entamoeba histolytica tyrosin kinase, putative 0.0059 0.006 0.0379
Schistosoma mansoni hypothetical protein 0.0534 0.0978 0.0973
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Schistosoma mansoni plexin 0.0534 0.0978 0.0973
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Trypanosoma cruzi PH domain containing protein, putative 0.0077 0.0095 0.4676
Plasmodium falciparum PH domain-containing protein, putative 0.0077 0.0095 0.7026
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0844 0.1576 1
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0098 0.0135 1
Brugia malayi Cytohesin 3 0.0077 0.0095 0.009
Loa Loa (eye worm) hypothetical protein 0.0225 0.038 0.0376
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0059 0.006 0.0066
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Loa Loa (eye worm) RGC/RGC protein kinase 0.0059 0.006 0.0055
Loa Loa (eye worm) TK/DDR protein kinase 0.0059 0.006 0.0055
Loa Loa (eye worm) rho-GTPase-activating 0.0077 0.0095 0.009
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0077 0.0095 0.0603
Entamoeba histolytica hypothetical protein 0.0077 0.0095 0.0603
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0093 0.0089
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0059 0.006 0.0066
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0059 0.006 0.0055
Entamoeba histolytica serine/threonine kinase, putative 0.0059 0.006 0.0379
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0098 0.0135 1
Loa Loa (eye worm) syntrophin-1 0.0077 0.0095 0.009
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Giardia lamblia Aurora kinase 0.0083 0.0107 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0008 0.0004
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0059 0.006 0.0066
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Brugia malayi Immunoglobulin I-set domain containing protein 0.0119 0.0176 0.0172
Toxoplasma gondii hypothetical protein 0.0077 0.0095 0.7026
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Brugia malayi Variant SH3 domain containing protein 0.0077 0.0095 0.009
Brugia malayi hypothetical protein 0.0119 0.0176 0.0172
Entamoeba histolytica ARF GTPase activating protein, putative 0.0077 0.0095 0.0603
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.006 0.0066
Brugia malayi PXA domain containing protein 0.0844 0.1576 0.1572
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Echinococcus multilocularis tyrosine protein kinase csk 0.0059 0.006 0.0066
Echinococcus multilocularis epidermal growth factor receptor 0.0059 0.006 0.0066
Echinococcus granulosus regulator of G protein signaling 3 0.0844 0.1576 0.1878
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.436 0.837 1
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Brugia malayi PH domain containing protein 0.0077 0.0095 0.009
Echinococcus granulosus tyrosine protein kinase csk 0.0059 0.006 0.0066
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0059 0.006 0.0066
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Schistosoma mansoni hypothetical protein 0.0077 0.0095 0.009
Onchocerca volvulus 0.0059 0.006 0.0318
Echinococcus multilocularis GRB2 associated binding protein 3 0.0077 0.0095 0.0108
Leishmania major hypothetical protein, conserved 0.0077 0.0095 0.7026
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0059 0.006 0.0066
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0059 0.006 0.0055
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus multilocularis epidermal growth factor receptor 0.0059 0.006 0.0066
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0077 0.0095 0.0522
Schistosoma mansoni protein kinase 0.008 0.01 0.0095
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0083 0.0107 0.0677
Schistosoma mansoni ephrin receptor 0.0059 0.006 0.0055
Echinococcus multilocularis tyrosine protein kinase pr2 0.0059 0.006 0.0066
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0059 0.006 0.0379
Schistosoma mansoni protein kinase 0.008 0.01 0.0095
Schistosoma mansoni protein kinase 0.0059 0.006 0.0055
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0844 0.1576 0.1572
Leishmania major protein kinase, putative 0.0098 0.0135 1
Entamoeba histolytica hypothetical protein 0.0059 0.006 0.0379
Loa Loa (eye worm) hypothetical protein 0.0394 0.0706 0.0702
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0059 0.006 0.0066
Brugia malayi SRC-1 0.0059 0.006 0.0055
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0077 0.0095 0.0483
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Schistosoma mansoni hypothetical protein 0.0172 0.0279 0.0274
Entamoeba histolytica protein kinase, putative 0.0098 0.0135 0.0858
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0093 0.0089
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0059 0.006 0.0055
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0059 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0077 0.0095 0.7026
Onchocerca volvulus 0.0059 0.006 0.0318
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Loa Loa (eye worm) TK/ROR protein kinase 0.0059 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0059 0.006 0.0055
Echinococcus multilocularis calcium dependent secretion activator 1 0.0077 0.0095 0.0108
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0059 0.006 0.0318
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0077 0.0095 0.0603
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0059 0.006 0.0256
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.006 0.0055
Entamoeba histolytica PH domain containing protein kinase, putative 0.0098 0.0135 0.0858
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0059 0.006 0.4414
Brugia malayi serine/threonine kinase 12 0.0083 0.0107 0.0102
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Loa Loa (eye worm) oxysterol binding protein 0.0077 0.0095 0.009
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus multilocularis transcription factor collier 0.0172 0.0279 0.0328
Brugia malayi Uncoordinated protein 104 0.0077 0.0095 0.009
Onchocerca volvulus 0.0059 0.006 0.0318
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Brugia malayi Receptor family ligand binding region containing protein 0.0059 0.006 0.0055
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0059 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Loa Loa (eye worm) AUR protein kinase 0.0083 0.0107 0.0102
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.5204 1 1
Brugia malayi TAR-binding protein 0.0076 0.0093 0.0089
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0077 0.0095 0.0603
Loa Loa (eye worm) hypothetical protein 0.0114 0.0166 0.0162
Entamoeba histolytica receptor protein kinase, putative 0.0059 0.006 0.0379
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Onchocerca volvulus 0.0059 0.006 0.0318
Loa Loa (eye worm) cytohesin 3 0.0077 0.0095 0.009
Brugia malayi PH domain containing protein 0.0077 0.0095 0.009
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1838 0.2191
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0059 0.006 0.0055
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Entamoeba histolytica hypothetical protein 0.0172 0.0279 0.1768
Onchocerca volvulus 0.0394 0.0706 0.4045
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Entamoeba histolytica protein kinase, putative 0.0083 0.0107 0.0677
Trypanosoma brucei protein kinase, putative 0.0098 0.0135 1
Entamoeba histolytica hypothetical protein, conserved 0.0077 0.0095 0.0603
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0 0.5
Brugia malayi Protein kinase domain containing protein 0.0315 0.0554 0.0549
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0059 0.006 0.0379
Schistosoma mansoni plexin 0.0928 0.1738 0.1734
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0107 0.0558
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0114 0.0166 0.0193
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0064 0.007 0.0078
Brugia malayi PH domain containing protein 0.0077 0.0095 0.009
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.006 0.0066
Onchocerca volvulus 0.0059 0.006 0.0318
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Schistosoma mansoni intermediate filament proteins 0.0033 0.0008 0.0004
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0083 0.0107 0.7884
Loa Loa (eye worm) PH domain-containing protein 0.0077 0.0095 0.009
Echinococcus granulosus fibroblast growth factor receptor 4 0.0059 0.006 0.0066
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0059 0.006 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Echinococcus granulosus tyrosine protein kinase Src64B 0.0059 0.006 0.0066
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0139 0.0135
Trypanosoma cruzi PH domain containing protein, putative 0.0077 0.0095 0.4676
Loa Loa (eye worm) hypothetical protein 0.0114 0.0166 0.0162
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0098 0.0135 1
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Echinococcus granulosus receptor type guanylyl cyclase 0.0059 0.006 0.0066
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0077 0.0095 0.0108
Trichomonas vaginalis AGC family protein kinase 0.0059 0.006 0.0256
Echinococcus granulosus dual specificity testis-specific protein kinase 0.008 0.01 0.0114
Trypanosoma cruzi hypothetical protein 0.0077 0.0095 0.4676
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0172 0.0279 0.1663
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Echinococcus multilocularis G protein coupled receptor kinase 6 0.436 0.837 1
Entamoeba histolytica protein kinase, putative 0.0098 0.0135 0.0858
Brugia malayi integrin-linked kinase 0.0059 0.006 0.0055
Plasmodium vivax protein kinase, putative 0.0059 0.006 0.4414
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0173 0.0281 0.0276
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.008 0.01 0.7388
Loa Loa (eye worm) hypothetical protein 0.0844 0.1576 0.1572
Schistosoma mansoni oxysterol-binding protein 1 0.0077 0.0095 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0279 0.1663
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.436 0.837 0.8369
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Trypanosoma cruzi hypothetical protein 0.0077 0.0095 0.4676
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0077 0.0095 0.009
Echinococcus multilocularis exocyst complex component 2 0.0172 0.0279 0.0328
Echinococcus granulosus activated cdc42 kinase 1 0.0059 0.006 0.0066
Trypanosoma cruzi hypothetical protein 0.0077 0.0095 0.4676
Echinococcus granulosus myotubularin protein 13 0.0077 0.0095 0.0108
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0098 0.0135 0.0742
Echinococcus granulosus tyrosine protein kinase csk 0.0059 0.006 0.0066
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Loa Loa (eye worm) TK/EGFR protein kinase 0.0059 0.006 0.0055
Echinococcus granulosus regulator of G protein signaling 7 0.0844 0.1576 0.1878
Schistosoma mansoni hypothetical protein 0.0077 0.0095 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Schistosoma mansoni goodpasture antigen-binding protein 0.0077 0.0095 0.009
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0059 0.006 0.0066
Loa Loa (eye worm) hypothetical protein 0.0059 0.006 0.0055
Brugia malayi hypothetical protein 0.0059 0.006 0.0055
Schistosoma mansoni lamin 0.0033 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0077 0.0095 0.009
Echinococcus granulosus tyrosine protein kinase Lyn 0.008 0.01 0.0114
Toxoplasma gondii protein kinase domain-containing protein 0.0059 0.006 0.4414
Echinococcus multilocularis tyrosine protein kinase shark 0.0059 0.006 0.0066
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0077 0.0095 0.0483
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0059 0.006 0.0379
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Plasmodium falciparum serine/threonine protein kinase, putative 0.0083 0.0107 0.7884
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0077 0.0095 0.009
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Echinococcus granulosus Pleckstrin y 0.0077 0.0095 0.0108
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0059 0.006 0.0055
Toxoplasma gondii hypothetical protein 0.0077 0.0095 0.7026
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Schistosoma mansoni protein kinase 0.0059 0.006 0.0055
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.006 0.0066
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0059 0.006 0.0066
Brugia malayi RNA binding protein 0.0076 0.0093 0.0089
Onchocerca volvulus 0.0059 0.006 0.0318
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.006 0.0066
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0059 0.006 0.0066
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0077 0.0095 0.4676
Loa Loa (eye worm) AGC/AKT protein kinase 0.0098 0.0135 0.0131
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Loa Loa (eye worm) TK/FAK protein kinase 0.0059 0.006 0.0055
Schistosoma mansoni vesicular amine transporter 0.0117 0.0172 0.0167
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Leishmania major protein kinase, putative 0.0098 0.0135 1
Onchocerca volvulus 0.0033 0.0008 0.0022
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Plasmodium falciparum oxysterol-binding protein, putative 0.0077 0.0095 0.7026
Echinococcus granulosus Regulator of G protein signaling 20 0.0844 0.1576 0.1878
Schistosoma mansoni hypothetical protein 0.0394 0.0706 0.0702
Brugia malayi hypothetical protein 0.0844 0.1576 0.1572
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0 0.5
Onchocerca volvulus 0.0059 0.006 0.0318
Trypanosoma brucei Pseudokinase, putative 0.0059 0.006 0.4414
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0059 0.006 0.0066
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.006 0.0055
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Loa Loa (eye worm) TK protein kinase 0.0059 0.006 0.0055
Onchocerca volvulus 0.0059 0.006 0.0318
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0077 0.0095 0.0603
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0083 0.0107 0.0677
Onchocerca volvulus 0.0077 0.0095 0.0522
Brugia malayi Furin-like cysteine rich region family protein 0.0059 0.006 0.0055
Entamoeba histolytica ankyrin repeat protein 0.0059 0.006 0.0379
Brugia malayi Syntrophin-1 0.0077 0.0095 0.009
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.006 0.0379
Brugia malayi MAX-1A 0.0077 0.0095 0.009
Echinococcus granulosus tyrosine protein kinase Srms 0.0059 0.006 0.0066
Loa Loa (eye worm) TK/ALK protein kinase 0.0315 0.0553 0.0549
Plasmodium falciparum protein kinase, putative 0.008 0.01 0.7388
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.006 0.0256
Trichomonas vaginalis centaurin beta, putative 0.0077 0.0095 0.0483
Schistosoma mansoni protein kinase 0.0083 0.0107 0.0102
Loa Loa (eye worm) uncoordinated protein 104 0.0077 0.0095 0.009
Echinococcus granulosus tyrosine protein kinase Src42A 0.0059 0.006 0.0066
Entamoeba histolytica protein kinase, putative 0.0098 0.0135 0.0858
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0095 0.0483
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0077 0.0095 0.7026
Echinococcus granulosus tyrosine kinase 0.0059 0.006 0.0066
Onchocerca volvulus 0.01 0.0139 0.0778
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0077 0.0095 0.0108
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Loa Loa (eye worm) hypothetical protein 0.0114 0.0166 0.0162
Onchocerca volvulus 0.0033 0.0008 0.0022
Trypanosoma cruzi hypothetical protein 0.0077 0.0095 0.4676
Brugia malayi Oxysterol-binding protein 0.0077 0.0095 0.009
Onchocerca volvulus 0.0077 0.0095 0.0522
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Echinococcus multilocularis ephrin type A receptor 4 A 0.0059 0.006 0.0066
Trypanosoma brucei Flagellum attachment zone protein 20 0.0059 0.006 0.4414
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0059 0.006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0844 0.1576 0.1572
Echinococcus granulosus tyrosine protein kinase csk 0.0059 0.006 0.0066
Schistosoma mansoni syntrophin 0.0077 0.0095 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0279 0.1663
Echinococcus multilocularis beta 1 syntrophin 0.0077 0.0095 0.0108
Schistosoma mansoni zinc finger protein 0.0077 0.0095 0.009
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0077 0.0095 0.4676
Onchocerca volvulus 0.0928 0.1738 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.006 0.0055
Entamoeba histolytica PH domain containing protein kinase, putative 0.0098 0.0135 0.0858
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.3989 0.7652 0.7651
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Toxoplasma gondii aurora kinase 0.0083 0.0107 0.7884
Loa Loa (eye worm) hypothetical protein 0.0033 0.0008 0.0004
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0059 0.006 0.0379
Brugia malayi Protein kinase domain containing protein 0.0059 0.006 0.0055
Echinococcus granulosus tyrosine protein kinase Blk 0.0059 0.006 0.0066
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0008 0.0004
Toxoplasma gondii protein kinase 0.0059 0.006 0.4414
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0077 0.0095 0.0603
Echinococcus granulosus lamin 0.0033 0.0008 0.0005
Trypanosoma cruzi hypothetical protein 0.0077 0.0095 0.4676
Brugia malayi Dynamin 0.0077 0.0095 0.009
Schistosoma mansoni ephrin receptor 0.0064 0.007 0.0065
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0077 0.0095 0.0603
Brugia malayi Plekhf2 protein 0.0077 0.0095 0.009
Echinococcus multilocularis tyrosine protein kinase HCK 0.0059 0.006 0.0066
Echinococcus granulosus epidermal growth factor receptor 0.0059 0.006 0.0066
Brugia malayi C-terminal src kinase protein 1 0.0059 0.006 0.0055
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0059 0.006 0.0055
Entamoeba histolytica hypothetical protein 0.0059 0.006 0.0379
Schistosoma mansoni regulator of G protein signaling 0.0844 0.1576 0.1572
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0077 0.0095 0.0108
Echinococcus granulosus natriuretic peptide receptor 1 0.0059 0.006 0.0066
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0098 0.0135 1
Entamoeba histolytica protein kinase, putative 0.0059 0.006 0.0379
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0032 0.0028
Schistosoma mansoni tyrosine kinase 0.0059 0.006 0.0055
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0059 0.006 0.0066
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0135 0.0742
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0083 0.0107 0.0122
Loa Loa (eye worm) TK/FER protein kinase 0.0059 0.006 0.0055
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0077 0.0095 0.0108
Entamoeba histolytica tyrosine kinase, putative 0.0059 0.006 0.0379
Entamoeba histolytica protein kinase , putative 0.0083 0.0107 0.0677
Echinococcus multilocularis natriuretic peptide receptor 1 0.0059 0.006 0.0066
Echinococcus granulosus regulator of G protein signaling 3 0.0844 0.1576 0.1878
Trichomonas vaginalis alpha chimerin, putative 0.0077 0.0095 0.0483
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0059 0.006 0.0055
Brugia malayi follicle stimulating hormone receptor 0.0283 0.0491 0.0487
Echinococcus granulosus insulin receptor 0.0059 0.006 0.0066
Trichomonas vaginalis TKL family protein kinase 0.0059 0.006 0.0256
Plasmodium vivax tyrosine kinase-like protein, putative 0.0059 0.006 0.4414
Echinococcus multilocularis tyrosine protein kinase 0.0059 0.006 0.0066
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0093 0.0089
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0059 0.006 0.0379

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 46.945 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) [Related pubchem assays: 1490 (qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase)), 1819 (Probe Development Summary of Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase))] ChEMBL. No reference
Potency (functional) 70.7946 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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