Detailed information for compound 1397784

Basic information

Technical information
  • TDR Targets ID: 1397784
  • Name: ethyl 5-(diethylcarbamoyl)-4-methyl-2-(9H-xan thene-9-carbonylamino)thiophene-3-carboxylate
  • MW: 492.587 | Formula: C27H28N2O5S
  • H donors: 1 H acceptors: 3 LogP: 5.67 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(NC(=O)C2c3ccccc3Oc3c2cccc3)sc(c1C)C(=O)N(CC)CC
  • InChi: 1S/C27H28N2O5S/c1-5-29(6-2)26(31)23-16(4)21(27(32)33-7-3)25(35-23)28-24(30)22-17-12-8-10-14-19(17)34-20-15-11-9-13-18(20)22/h8-15,22H,5-7H2,1-4H3,(H,28,30)
  • InChiKey: VWXTZRAGSPUDEM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(diethylamino-oxomethyl)-4-methyl-2-[[oxo-(9H-xanthen-9-yl)methyl]amino]-3-thiophenecarboxylic acid ethyl ester
  • 5-(diethylcarbamoyl)-4-methyl-2-(9H-xanthene-9-carbonylamino)thiophene-3-carboxylic acid ethyl ester
  • ethyl 5-(diethylcarbamoyl)-4-methyl-2-(9H-xanthen-9-ylcarbonylamino)thiophene-3-carboxylate
  • ethyl 5-[(diethylamino)carbonyl]-4-methyl-2-[(9H-xanthen-9-ylcarbonyl)amino]-3-thiophenecarboxylate
  • IVK/8188749
  • MLS000545797
  • SMR000159422
  • Oprea1_290520
  • ZINC00671166
  • AK-968/13025296

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0036 0.0074 0.0518
Onchocerca volvulus 0.0038 0.0078 0.1256
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.0866 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0012 0.0084
Echinococcus multilocularis RUN 0.0021 0.0036 0.0036
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0276 0.0652 0.4548
Mycobacterium leprae Probable lipase LipE 0.0038 0.0078 0.2664
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Schistosoma mansoni DNA ligase IV 0.004 0.0082 0.0564
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0078 0.0865
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0012 0.0012
Onchocerca volvulus Serine\/threonine kinase homolog 0.0116 0.0265 0.4409
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0078 0.1166
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0108 0.0526
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Onchocerca volvulus 0.0038 0.0078 0.1256
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0036 0.0177
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0012 0.0059
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0012 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.0265 0.4054
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.002
Onchocerca volvulus Glucosylceramidase homolog 0.0181 0.0423 0.7058
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0012 0.0083
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0065 0.0446
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Loa Loa (eye worm) hypothetical protein 0.0074 0.0165 0.1154
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0094 0.1421
Echinococcus granulosus tyrosine protein kinase Fyn 0.0006 0.0002 0.0008
Echinococcus multilocularis smad 0.001 0.001 0.001
Brugia malayi TAZ zinc finger family protein 0.0007 0.0003 0.002
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0334 0.2333
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Brugia malayi MH2 domain containing protein 0.001 0.001 0.0071
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0071 0.0494
Plasmodium vivax acyl-CoA synthetase, putative 0.0089 0.0201 1
Onchocerca volvulus 0.0036 0.0074 0.1199
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0006 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0071 0.0494
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0078 0.1604
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0065 0.0446
Onchocerca volvulus 0.0098 0.0222 0.3678
Echinococcus granulosus Smad4 0.001 0.001 0.005
Echinococcus granulosus expressed conserved protein 0.0563 0.1345 0.655
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0078 0.1266
Toxoplasma gondii bromodomain-containing protein 0.0007 0.0003 0.0000000046332
Brugia malayi MH1 domain containing protein 0.001 0.001 0.0071
Echinococcus granulosus smad 0.001 0.001 0.005
Entamoeba histolytica hypothetical protein 0.0145 0.0336 0.233
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0446 0.6842
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0012 0.0084
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.0568 1
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Brugia malayi Bromodomain containing protein 0.0085 0.019 0.1329
Loa Loa (eye worm) beta-lactamase 0.0038 0.0078 0.0541
Echinococcus granulosus nibrin 0.004 0.0082 0.04
Echinococcus multilocularis peregrin 0.0007 0.0003 0.0003
Onchocerca volvulus Huntingtin homolog 0.0148 0.0343 0.5722
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.004 0.0082 0.0555
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0012 0.0155
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0287 0.0678 0.7818
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0119 0.0273 0.6022
Echinococcus granulosus replication factor c subunit 1 0.004 0.0082 0.04
Schistosoma mansoni hypothetical protein 0.0007 0.0003 0.0019
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0071 0.0787
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0094 0.0458
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Schistosoma mansoni lipoxygenase 0.0086 0.0195 0.134
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0035 0.0071 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0089 0.0201 0.3462
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0024 0.0024
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0035 0.0071 0.0345
Echinococcus multilocularis polybromo 1 0.0007 0.0003 0.0003
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0035 0.0071 0.2409
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0082 0.0919
Loa Loa (eye worm) hypothetical protein 0.0052 0.0112 0.0782
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0035 0.0071 0.2409
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.001 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0078 0.0865
Trichomonas vaginalis bromodomain-containing protein 3, brd3, putative 0.0007 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.002
Brugia malayi ecdysteroid receptor 0.0011 0.0012 0.0084
Echinococcus multilocularis tumor protein p63 0.07 0.1676 0.1676
Brugia malayi Smad1 0.001 0.001 0.0071
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0541
Schistosoma mansoni smad 0.001 0.001 0.007
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0035 0.0071 0.1145
Entamoeba histolytica hypothetical protein 0.004 0.0082 0.0555
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0007 0.0003 0.0016
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0015 0.0103
Brugia malayi Patched related family protein 12 0.0036 0.0074 0.0518
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0154 0.0358 0.0358
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0024 0.003
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0012 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0012 0.0084
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0006 0.0002 0.0002
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.0007 0.0003 0.0014
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0334 0.2333
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0138 0.0962
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0012 0.0084
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0089 0.0201 0.4386
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0652 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0112 0.0546
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0541
Echinococcus multilocularis nibrin 0.004 0.0082 0.0082
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0035 0.0071 0.1451
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0078 0.0865
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0024 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Brugia malayi SRC-1 0.0006 0.0002 0.0012
Loa Loa (eye worm) patched family protein 0.0036 0.0074 0.0518
Brugia malayi acetyltransferase, GNAT family protein 0.0178 0.0415 0.2894
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0012 0.0084
Echinococcus multilocularis dual specificity 0.0287 0.0678 0.0678
Entamoeba histolytica ankyrin repeat protein, putative 0.0007 0.0003 0.000000022518
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.0579 0.4042
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0012 0.0061
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.004 0.0082 0.0919
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Trichomonas vaginalis bromodomain containing protein, putative 0.0007 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0257 0.0607 0.4238
Schistosoma mansoni polybromo-1 0.0007 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Echinococcus multilocularis global transcription activator snf2l2 0.0007 0.0003 0.0003
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0244
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0166 0.1155
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0012 0.0084
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.0866 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0119 0.0273 0.1893
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Entamoeba histolytica protein kinase, putative 0.0287 0.0678 0.4721
Leishmania major hypothetical protein, conserved 0.0038 0.0078 0.0865
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0012 0.0012
Trichomonas vaginalis bromodomain-containing protein, putative 0.0054 0.0117 0.1768
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0084 0.0189 0.3253
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0119 0.0273 0.1893
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0006 0.0042
Echinococcus granulosus bromodomain containing 2 0.0007 0.0003 0.0014
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.0265 0.4054
Echinococcus multilocularis c src tyrosine kinase 0.0006 0.0002 0.0002
Echinococcus granulosus bromodomain containing protein 8 0.0007 0.0003 0.0014
Trichomonas vaginalis bromodomain containing protein, putative 0.0007 0.0003 0.0016
Loa Loa (eye worm) SRC-1 0.0006 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0541
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0012 0.0059
Brugia malayi polybromodomain protein 0.0007 0.0003 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0209 0.0209
Echinococcus granulosus Protein patched homolog 1 0.0257 0.0607 0.2957
Brugia malayi protein C24B5.3 0.0036 0.0074 0.0518
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0012 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0423 0.648
Echinococcus granulosus Bromodomain containing protein 0.0007 0.0003 0.0014
Loa Loa (eye worm) hypothetical protein 0.004 0.0084 0.0583
Brugia malayi nuclear hormone receptor 0.0011 0.0012 0.0084
Schistosoma mansoni chromosome transmission fidelity factor 0.004 0.0082 0.0564
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0071 0.1061
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0024 0.0311
Plasmodium falciparum lipid/sterol:H+ symporter 0.0036 0.0074 0.3603
Schistosoma mansoni apoferritin-2 0.0008 0.0006 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0423 0.648
Trichomonas vaginalis bromodomain containing protein, putative 0.0007 0.0003 0.0016
Echinococcus granulosus GPCR family 2 0.0052 0.0112 0.0546
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Trichomonas vaginalis ferritin, putative 0.0008 0.0006 0.0071
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.0265 0.4054
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0071 0.0787
Giardia lamblia Kinase, PLK 0.0116 0.0265 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0094 0.0638
Brugia malayi Pre-SET motif family protein 0.0032 0.0065 0.0453
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0287 0.0678 0.7818
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0082 0.1237
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Schistosoma mansoni smad1 5 8 and 0.001 0.001 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Schistosoma mansoni ferritin light chain 0.0008 0.0006 0.0044
Echinococcus granulosus neuropeptide s receptor 0.056 0.1338 0.6514
Loa Loa (eye worm) hypothetical protein 0.0063 0.014 0.0974
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.0285 0.1387
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.0947 0.0947
Brugia malayi Ets-domain containing protein 0.0074 0.0166 0.1155
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0087
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Echinococcus granulosus tyrosine protein kinase Src42A 0.0006 0.0002 0.0008
Loa Loa (eye worm) patched family protein 0.0036 0.0074 0.0518
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.011 0.1244
Mycobacterium ulcerans acyl-CoA synthetase 0.0119 0.0273 0.6022
Loa Loa (eye worm) hypothetical protein 0.004 0.0082 0.0573
Schistosoma mansoni ets 0.0011 0.0012 0.0086
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0012 0.0083
Brugia malayi Bromodomain containing protein 0.0007 0.0003 0.002
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0071 0.1451
Echinococcus granulosus tumor protein p63 0.07 0.1676 0.8163
Schistosoma mansoni zinc finger protein 0.0026 0.005 0.0345
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0012 0.0012
Entamoeba histolytica protein kinase domain containing protein 0.0287 0.0678 0.4721
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0094 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0209 0.1461
Entamoeba histolytica hypothetical protein 0.0145 0.0336 0.233
Echinococcus granulosus survival motor neuron protein 1 0.0478 0.114 0.5551
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Loa Loa (eye worm) hypothetical protein 0.004 0.0082 0.0573
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Brugia malayi ATPase, AAA family protein 0.0007 0.0003 0.002
Schistosoma mansoni ferritin light chain 0.0008 0.0006 0.0044
Onchocerca volvulus 0.0035 0.0071 0.1141
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0007 0.0003 0.0016
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0116 0.0265 0.1851
Toxoplasma gondii propionate-CoA ligase 0.0035 0.0071 0.0098
Echinococcus granulosus neuropeptide receptor A26 0.056 0.1338 0.6514
Schistosoma mansoni bromodomain containing protein 0.001 0.0012 0.0079
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0078 0.0533
Echinococcus multilocularis protein patched 0.0257 0.0607 0.0607
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0119 0.0273 0.4753
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Schistosoma mansoni bromodomain containing protein 0.0072 0.0161 0.1105
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0287 0.0678 0.7818
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0006 0.0002 0.0002
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0089 0.4351
Brugia malayi Niemann-Pick C1 protein precursor 0.06 0.1433 1
Brugia malayi protein C24B5.3 0.0036 0.0074 0.0518
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0035 0.0071 0.0098
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0423 0.648
Loa Loa (eye worm) hypothetical protein 0.005 0.0108 0.0754
Echinococcus multilocularis sterol regulatory element binding protein 0.0257 0.0607 0.0607
Schistosoma mansoni hypothetical protein 0.0112 0.0258 0.1771
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0403 0.4633
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0652 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Brugia malayi Ets-domain containing protein 0.0074 0.0166 0.1155
Loa Loa (eye worm) oxidoreductase 0.0035 0.0071 0.0494
Schistosoma mansoni tyrosine kinase 0.0151 0.0352 0.2418
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0035 0.0071 0.0071
Loa Loa (eye worm) Smad1 0.001 0.001 0.0071
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0652 1
Brugia malayi Bromodomain containing protein 0.0007 0.0003 0.002
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0012 0.0012
Loa Loa (eye worm) acetyltransferase 0.0178 0.0415 0.2894
Echinococcus multilocularis expressed conserved protein 0.0563 0.1345 0.1345
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0152 0.0739
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0423 0.648
Brugia malayi follicle stimulating hormone receptor 0.0246 0.0579 0.4042
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0138 0.0962
Brugia malayi Pax transcription activation domain interacting protein 0.004 0.0082 0.0573
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0084
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0082 0.1237
Schistosoma mansoni ferritin 0.0008 0.0006 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0012 0.0084
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.0117 0.0568
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0012 0.0083
Toxoplasma gondii patched family protein 0.0036 0.0074 0.0103
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0078 0.1266
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0012 0.0083
Leishmania major 4-coumarate:coa ligase-like protein 0.0119 0.0273 0.3134
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0012 0.0083
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0071 0.1145
Trichomonas vaginalis lymphoid specific helicase, putative 0.0007 0.0003 0.0016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Schistosoma mansoni Smad4 0.001 0.001 0.007
Loa Loa (eye worm) fli-1 protein 0.0225 0.053 0.3698
Schistosoma mansoni transcription initiation factor tfiid 0.0007 0.0003 0.0019
Brugia malayi nuclear receptor NHR-88 0.0011 0.0012 0.0084
Brugia malayi AMP-binding enzyme family protein 0.0119 0.0273 0.1909
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.004 0.0082 0.2836
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0012 0.0012
Echinococcus multilocularis neuropeptide receptor A26 0.056 0.1338 0.1338
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.002
Schistosoma mansoni gabp alpha 0.0074 0.0166 0.1137
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0133 0.0188
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0006 0.003
Onchocerca volvulus 0.0036 0.0074 0.1199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0209 0.1439
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0446 0.6842
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0006 0.0006
Schistosoma mansoni ets-related 0.0225 0.053 0.3641
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0012 0.0061
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0006 0.0002 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.0265 0.4054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0012 0.0084
Schistosoma mansoni cpg binding protein 0.0032 0.0063 0.043
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0071 0.1451
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0012 0.0084
Echinococcus granulosus zinc finger protein 0.0026 0.005 0.0244
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.003 0.0059 0.0937
Loa Loa (eye worm) RNA binding protein 0.0063 0.0138 0.0962
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0397 0.1933
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Schistosoma mansoni topbp1 0.004 0.0082 0.0564
Loa Loa (eye worm) hypothetical protein 0.004 0.0082 0.0573
Schistosoma mansoni hypothetical protein 0.0022 0.0039 0.0266
Echinococcus granulosus sterol regulatory element binding protein 0.0257 0.0607 0.2957
Echinococcus granulosus tyrosine protein kinase Src64B 0.0006 0.0002 0.0008
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Loa Loa (eye worm) patched family protein 0.0036 0.0074 0.0518
Loa Loa (eye worm) hypothetical protein 0.0148 0.0343 0.2397
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Toxoplasma gondii hypothetical protein 0.0059 0.0128 0.0181
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.001 0.001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0112 0.0782
Schistosoma mansoni zinc finger protein 0.0016 0.0025 0.0173
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0071 0.0494
Echinococcus granulosus dnaJ subfamily B 0.0398 0.0947 0.4612
Trichomonas vaginalis conserved hypothetical protein 0.0257 0.0607 0.9317
Trichomonas vaginalis bromodomain containing protein, putative 0.0007 0.0003 0.0016
Echinococcus granulosus expressed protein 0.0008 0.0006 0.0031
Entamoeba histolytica serine/threonine protein kinase, putative 0.0116 0.0265 0.1835
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0035 0.0071 0.1145
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0024 0.0167
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0222 0.1548
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.003 0.003
Brugia malayi Bromodomain containing protein 0.0007 0.0003 0.002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0012 0.0084
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0035 0.0071 0.1145
Echinococcus multilocularis replication factor c subunit 1 0.004 0.0082 0.0082
Entamoeba histolytica acyl-coA synthetase, putative 0.0119 0.0273 0.1893
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0164 0.0383 0.2675
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0094 0.0131
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus multilocularis cpg binding protein 0.0032 0.0063 0.0063
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Schistosoma mansoni patched 1 0.0257 0.0607 0.4172
Echinococcus multilocularis Niemann Pick C1 protein 0.06 0.1433 0.1433
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0071 0.1451
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0071 0.1451
Toxoplasma gondii ABC1 family protein 0.0038 0.0078 0.0108
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0035 0.0071 0.1451
Schistosoma mansoni hypothetical protein 0.0052 0.0112 0.077
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Onchocerca volvulus 0.0021 0.0036 0.0563
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0078 0.1266
Schistosoma mansoni hypothetical protein 0.0007 0.0003 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0082 0.1237
Schistosoma mansoni tyrosine kinase 0.0006 0.0002 0.0012
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0035 0.0071 0.1451
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.0258 0.1799
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0012 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0035 0.0071 0.1145
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0012 0.0059
Brugia malayi CHE-14 protein 0.0257 0.0607 0.4238
Schistosoma mansoni hypothetical protein 0.0021 0.0036 0.025
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus multilocularis bromodomain containing 2 0.0007 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.002
Schistosoma mansoni hypothetical protein 0.0248 0.0585 0.4019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0084 0.0189 0.3253
Mycobacterium tuberculosis Conserved protein 0.0038 0.0078 0.1266
Echinococcus granulosus dual specificity 0.0287 0.0678 0.3301
Brugia malayi hypothetical protein 0.0145 0.0336 0.2345
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0012 0.0061
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0071 0.0787
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0209 0.1439
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0035 0.0071 0.2409
Brugia malayi Bromodomain containing protein 0.0044 0.0094 0.0654
Echinococcus multilocularis tyrosine protein kinase Abl 0.0006 0.0002 0.0002
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Echinococcus multilocularis protein dispatched 1 0.0294 0.0695 0.0695
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0209 0.1439
Trichomonas vaginalis hypothetical protein 0.0007 0.0003 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0082 0.0919
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0006 0.0002 0.0002
Plasmodium vivax acetyl-CoA synthetase, putative 0.0035 0.0071 0.3429
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus multilocularis ets variant gene 4 0.0011 0.0012 0.0012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0164 0.0383 0.2675
Mycobacterium tuberculosis Conserved protein 0.0038 0.0078 0.1266
Schistosoma mansoni hypothetical protein 0.0052 0.0112 0.077
Trichomonas vaginalis CAMK family protein kinase 0.0058 0.0126 0.1916
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.045 0.7893
Onchocerca volvulus 0.0036 0.0074 0.1199
Schistosoma mansoni hypothetical protein 0.0007 0.0003 0.0019
Schistosoma mansoni hypothetical protein 0.0042 0.0089 0.0612
Brugia malayi MH2 domain containing protein 0.0144 0.0334 0.2333
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0047 0.0047
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0138 0.0947
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0078 0.0378
Schistosoma mansoni smad1 5 8 and 0.001 0.001 0.007
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0166 0.0806
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0094 0.1421
Brugia malayi Pre-SET motif family protein 0.0223 0.0524 0.3657
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0012 0.0061
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0006 0.0002 0.0002
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0006 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0012 0.0084
Schistosoma mansoni hypothetical protein 0.0011 0.0012 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Brugia malayi Tyrosine-protein kinase abl-1 0.0006 0.0002 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.0678 0.4658
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0071 0.1145
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0036 0.0177
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0652 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0084 0.0189 0.3253
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.001 0.005
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0178 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Brugia malayi Patched protein homolog 1 0.0036 0.0074 0.0518
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0119 0.0273 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0089 0.0201 1
Trypanosoma cruzi ISWI complex protein 0.0016 0.0025 0.0259
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0423 0.648
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0257 0.0607 0.4238
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0035 0.0071 0.1451
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0035 0.0071 0.0494
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0541
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0082 0.0919
Trichomonas vaginalis bromodomain and PHD finger-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0166 0.0166
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Echinococcus granulosus polybromo 1 0.0007 0.0003 0.0014
Echinococcus multilocularis protein kinase C binding protein 1 0.0007 0.0003 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0012 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0209 0.102
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Loa Loa (eye worm) CBP-B 0.0007 0.0003 0.002
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0036 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0423 0.648
Schistosoma mansoni rab6-interacting 0.0021 0.0036 0.025
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.0524 0.3657
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0024 0.0244
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0024 0.0167
Brugia malayi beta-lactamase 0.0038 0.0078 0.0541
Schistosoma mansoni CREB-binding protein 2 0.0007 0.0003 0.0019
Echinococcus multilocularis 0.0007 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0035 0.0071 0.1451
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0007 0.0004 0.0039
Onchocerca volvulus 0.0119 0.0273 0.4547
Echinococcus multilocularis Smad4 0.001 0.001 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0119 0.0273 0.6022
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0094 0.1057
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0047 0.0231
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0094 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0071 0.1451
Echinococcus multilocularis expressed protein 0.0008 0.0006 0.0006
Onchocerca volvulus 0.0038 0.0078 0.1256
Trypanosoma brucei polo-like protein kinase 0.0116 0.0265 0.3039
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0423 0.648
Loa Loa (eye worm) hypothetical protein 0.06 0.1433 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0119 0.0273 0.1909
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0094 0.1057
Schistosoma mansoni rab6-interacting 0.0021 0.0036 0.025
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0024 0.0024
Brugia malayi Protein kinase domain containing protein 0.0287 0.0678 0.4731
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0012 0.0084
Entamoeba histolytica hypothetical protein 0.0145 0.0336 0.233
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.004 0.0082 0.0573
Brugia malayi BRM protein 0.0007 0.0003 0.002
Echinococcus granulosus global transcription activator snf2l2 0.0007 0.0003 0.0014
Giardia lamblia Replication factor C, subunit 1 0.004 0.0082 0.3023
Schistosoma mansoni hypothetical protein 0.0398 0.0947 0.6508
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0138 0.0947
Brugia malayi beta-lactamase family protein 0.0038 0.0078 0.0541
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0012 0.0059
Loa Loa (eye worm) hypothetical protein 0.0119 0.0273 0.1909
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0035 0.0071 0.1451
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0078 0.3772
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0007 0.0004 0.0039
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0078 0.2664
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0036 0.0177
Echinococcus granulosus cpg binding protein 0.0032 0.0063 0.0305
Onchocerca volvulus 0.004 0.0082 0.1333
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0078 0.0541
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.002
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0012 0.0087
Schistosoma mansoni bromodomain containing protein 0.0007 0.0003 0.0019
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0047 0.0325
Schistosoma mansoni hypothetical protein 0.0248 0.0585 0.4019
Loa Loa (eye worm) hypothetical protein 0.0103 0.0234 0.1632
Brugia malayi serine/threonine-protein kinase plk-2 0.0116 0.0265 0.1851
Trichomonas vaginalis replication factor C large subunit, putative 0.004 0.0082 0.1237
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.0265 0.4054
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus granulosus tyrosine protein kinase Fyn 0.0006 0.0002 0.0008
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0071 0.0787
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0494
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0541
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Onchocerca volvulus 0.0035 0.0071 0.1141
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0209 0.0209
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Onchocerca volvulus 0.0036 0.0074 0.1199
Plasmodium falciparum acyl-CoA synthetase 0.0089 0.0201 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.01 0.0697
Schistosoma mansoni ets-related 0.0011 0.0012 0.0086
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0083 0.136
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Schistosoma mansoni hypothetical protein 0.0007 0.0003 0.0019
Brugia malayi MH2 domain containing protein 0.001 0.001 0.0071
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0012 0.0084
Mycobacterium ulcerans acyl-CoA synthetase 0.0119 0.0273 0.6022
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0138 0.0947
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0119 0.0273 0.4753
Onchocerca volvulus Protein patched homolog 0.0036 0.0074 0.1199
Schistosoma mansoni transcription factor LCR-F1 0.0145 0.0336 0.2309
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0012 0.0155
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0007 0.0003 0.0016
Echinococcus granulosus protein C ets 2 0.0011 0.0012 0.0061
Loa Loa (eye worm) BRM protein 0.0007 0.0003 0.002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0061 0.0295
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0007 0.0003 0.0019
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0012 0.0083
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0007 0.0003 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0112 0.0782
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0094 0.1057
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0276 0.0652 0.4548
Echinococcus multilocularis ferritin 0.0008 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0084
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0089 0.0621
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Schistosoma mansoni tyrosine kinase 0.0006 0.0002 0.0012
Brugia malayi Myosin head containing protein 0.0036 0.0074 0.0518
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0012 0.0012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0109 0.0758
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.01 0.4921
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0082 0.1237
Brugia malayi hypothetical protein 0.0036 0.0074 0.0518
Echinococcus granulosus ferritin 0.0008 0.0006 0.0031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0084 0.0189 0.3253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0012 0.0084
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0012 0.0061
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0112 0.0782
Mycobacterium ulcerans lipase LipD 0.0038 0.0078 0.1604
Toxoplasma gondii patched family protein 0.0036 0.0074 0.0103
Trichomonas vaginalis bromodomain containing protein, putative 0.0007 0.0003 0.0016
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0035 0.0071 0.1145
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0071 0.1145
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0036 0.1693
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0116
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0287 0.0678 0.4731
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0007 0.0003 0.0019
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0012 0.0083
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0012 0.0083
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0071 0.1451
Trypanosoma cruzi ISWI complex protein 0.0016 0.0025 0.0259
Brugia malayi hypothetical protein 0.0036 0.0074 0.0518
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0078 0.0078
Brugia malayi Bromodomain containing protein 0.0007 0.0003 0.002
Onchocerca volvulus 0.0036 0.0074 0.1199
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0084
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0265 0.1823
Brugia malayi polybromodomain protein 0.0007 0.0003 0.002
Brugia malayi hypothetical protein 0.004 0.0082 0.0573
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.004 0.0082 0.1237
Brugia malayi CXXC zinc finger family protein 0.0028 0.0054 0.0376
Echinococcus multilocularis protein C ets 2 0.0011 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0016 0.0025 0.0173
Treponema pallidum DNA ligase (lig) 0.004 0.0082 1
Loa Loa (eye worm) hypothetical protein 0.0478 0.114 0.7956
Leishmania major acetyl-CoA synthetase, putative 0.0035 0.0071 0.0787
Schistosoma mansoni cpg binding protein 0.0032 0.0063 0.043
Echinococcus granulosus RUN 0.0021 0.0036 0.0177
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Trypanosoma cruzi polo-like protein kinase, putative 0.0116 0.0265 0.3039
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0006 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0089 0.0201 0.1402
Trypanosoma brucei AAA ATPase, putative 0.0007 0.0003 0.0000039754
Loa Loa (eye worm) hypothetical protein 0.0089 0.0201 0.1402
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0012 0.0084
Schistosoma mansoni polycystin 1-related 0.0021 0.0036 0.025
Loa Loa (eye worm) hypothetical protein 0.004 0.0082 0.0573
Schistosoma mansoni apoferritin-2 0.0008 0.0006 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0108 0.0742
Brugia malayi Doublecortin family protein 0.0021 0.0036 0.0254
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0035 0.0071 0.0494
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Onchocerca volvulus 0.0103 0.0234 0.3881
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0012 0.0083
Schistosoma mansoni kinase 0.0059 0.013 0.0893
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0012 0.0086
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.001 0.005
Plasmodium vivax SET domain protein, putative 0.0032 0.0065 0.3131
Trichomonas vaginalis bromodomain-containing protein 4, brd4, putative 0.0007 0.0003 0.0016
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0078 0.1166
Brugia malayi Bromodomain containing protein 0.0007 0.0003 0.002
Onchocerca volvulus 0.0011 0.0012 0.0155
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0012 0.0059
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0254
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0078 0.1166
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0083 0.2861
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0036 0.1693
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0071 0.0494
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0012 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0082 0.1237
Echinococcus granulosus tyrosine protein kinase Lyn 0.0008 0.0006 0.003
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0036 0.0254
Schistosoma mansoni hypothetical protein 0.0052 0.0112 0.077
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0036 0.0036
Brugia malayi beta-lactamase family protein 0.0038 0.0078 0.0541
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0094 0.1977
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0254
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0078 0.0533
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0012 0.0087
Loa Loa (eye worm) histone methyltransferase 0.001 0.001 0.0071
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Schistosoma mansoni cpg binding protein 0.0028 0.0054 0.0371
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0164 0.0383 0.2675
Mycobacterium tuberculosis Conserved protein 0.0038 0.0078 0.1266
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0006 0.0002 0.0008
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0006 0.003
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0035 0.0071 0.0787
Brugia malayi hypothetical protein 0.0036 0.0074 0.0518
Toxoplasma gondii patched family protein 0.0036 0.0074 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Onchocerca volvulus 0.0036 0.0074 0.1199
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.004 0.0082 0.0114
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.004 0.0082 0.1237
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0178 0.0415 0.285
Schistosoma mansoni inositol monophosphatase 0.0045 0.0094 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0082 0.1237
Onchocerca volvulus 0.0035 0.0071 0.1141
Trichomonas vaginalis antibiotic synthetase, putative 0.0035 0.0071 0.1061
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0071 0.0494
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0652 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0209 0.102
Schistosoma mansoni ferritin 0.0008 0.0006 0.0044
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0006 0.0006
Trypanosoma cruzi polo-like protein kinase, putative 0.0116 0.0265 0.3039
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.0285 0.0285
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0012 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0071 0.1451
Schistosoma mansoni coup transcription factor 0.0011 0.0012 0.0083
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0145 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0087
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0621
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0071 0.0787
Onchocerca volvulus 0.0036 0.0074 0.1199
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0012 0.0084
Onchocerca volvulus 0.0021 0.0036 0.0563
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.001 0.0071
Schistosoma mansoni tyrosine kinase 0.0006 0.0002 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0078 0.1166
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0116 0.0265 0.3039
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.0007 0.0003 0.0014
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0077 0.0377
Schistosoma mansoni ferritin 0.0008 0.0006 0.0044
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0012 0.0012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0137 0.1557
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0024 0.1062
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0094 0.1057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0119 0.0273 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0201 0.1402
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0024 0.0164
Schistosoma mansoni acetyl-CoA synthetase 0.0035 0.0071 0.0486
Onchocerca volvulus Protein patched homolog 0.0036 0.0074 0.1199
Echinococcus granulosus CREB binding protein 0.0007 0.0003 0.0014
Echinococcus multilocularis Bromodomain containing protein 0.0007 0.0003 0.0003
Echinococcus multilocularis Niemann Pick C1 protein 0.0857 0.2054 0.2054
Loa Loa (eye worm) patched family protein 0.0036 0.0074 0.0518
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0012 0.0084
Echinococcus granulosus PH interacting protein 0.0007 0.0003 0.0014
Echinococcus multilocularis bromodomain containing protein 8 0.0007 0.0003 0.0003
Schistosoma mansoni ferritin 0.0008 0.0006 0.0044
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.0866 1
Loa Loa (eye worm) hypothetical protein 0.0285 0.0674 0.47
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0403 0.4633
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0042 0.029
Toxoplasma gondii ATPase, AAA family protein 0.004 0.0082 0.0114
Mycobacterium ulcerans beta-lactamase 0.0038 0.0078 0.1604
Brugia malayi hypothetical protein 0.0148 0.0343 0.2397
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0006 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0012 0.0084
Echinococcus granulosus peregrin 0.0007 0.0003 0.0014
Echinococcus granulosus Bromodomain containing protein 0.0007 0.0003 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0071 0.1451
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0012 0.0084
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0012 0.0059
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Entamoeba histolytica hypothetical protein 0.0145 0.0336 0.233
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0089 0.0621
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0112 0.0546
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0065 0.0065
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.0265 0.4054
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0494
Brugia malayi MH1 domain containing protein 0.001 0.001 0.0071
Entamoeba histolytica protein kinase, putative 0.0287 0.0678 0.4721
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0035 0.0071 0.1145
Brugia malayi Inositol-1 0.0045 0.0094 0.0657
Plasmodium vivax replication factor C subunit 1, putative 0.004 0.0082 0.4004
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0054 0.0117 0.1768
Echinococcus multilocularis zinc finger protein 0.0026 0.005 0.005
Brugia malayi Bromodomain containing protein 0.0007 0.0003 0.002
Plasmodium vivax SET domain containing protein 0.0009 0.0007 0.0217
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Schistosoma mansoni survival motor neuron protein 0.0098 0.0222 0.1524
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.011 0.1244
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.001 0.007
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0116 0.0265 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.0007 0.0003 0.0003
Echinococcus multilocularis survival motor neuron protein 1 0.0478 0.114 0.114
Mycobacterium ulcerans acetyl-CoA synthetase 0.0035 0.0071 0.1451
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Plasmodium vivax patched family protein, putative 0.0036 0.0074 0.3603
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Loa Loa (eye worm) inositol-1 0.0045 0.0094 0.0657
Trichomonas vaginalis CAMK family protein kinase 0.0058 0.0126 0.1916
Loa Loa (eye worm) bromodomain containing protein 0.0007 0.0003 0.002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Schistosoma mansoni hypothetical protein 0.0098 0.0222 0.1524
Mycobacterium ulcerans hypothetical protein 0.0038 0.0078 0.1604
Schistosoma mansoni hypothetical protein 0.0145 0.0336 0.2309
Brugia malayi Bromodomain containing protein 0.0007 0.0003 0.002
Onchocerca volvulus Huntingtin homolog 0.0148 0.0343 0.5722
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0094 0.1421
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0078 0.1604
Loa Loa (eye worm) patched family protein 0.0036 0.0074 0.0518
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0152 0.0152
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0035 0.0071 0.0787
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0089 0.0621
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.011 0.1244
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0541
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0054 0.0117 0.0164
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0035 0.0071 0.1451
Schistosoma mansoni hypothetical protein 0.0248 0.0585 0.4019
Plasmodium falciparum bromodomain protein 1 0.0007 0.0003 0.00000016256
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0006 0.0002 0.0008
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0244
Brugia malayi hypothetical protein 0.0038 0.0079 0.0552
Schistosoma mansoni elf1 0.0011 0.0012 0.0086
Echinococcus multilocularis GPCR, family 2 0.0052 0.0112 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0012 0.0059
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0078 0.1166
Toxoplasma gondii patched family protein 0.0036 0.0074 0.0103
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0652 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0012 0.0084
Loa Loa (eye worm) hypothetical protein 0.0119 0.0273 0.1909
Loa Loa (eye worm) hypothetical protein 0.0315 0.0747 0.5212
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.001 0.001
Brugia malayi PHD-finger family protein 0.0032 0.0064 0.0445
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Brugia malayi isocitrate dehydrogenase 0.0015 0.0024 0.0167
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.004 0.0082 0.1708
Onchocerca volvulus 0.0028 0.0054 0.0859
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Leishmania major hypothetical protein, conserved 0.0016 0.0025 0.0259
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0609 0.1455 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0078 0.1266
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0089 0.4351
Mycobacterium ulcerans hypothetical protein 0.0192 0.045 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0078 0.0541
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0012 0.0084
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.004 0.0082 0.8637
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0024 0.1062
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0145 0.0336 0.1636
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0089 0.0089
Schistosoma mansoni phd finger protein 0.0007 0.0003 0.0019
Schistosoma mansoni topbp1 0.004 0.0082 0.0564
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0012 0.0155
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0119 0.0273 0.6022
Trichomonas vaginalis esterase, putative 0.0038 0.0078 0.1166
Trichomonas vaginalis set domain proteins, putative 0.0253 0.0598 0.9175
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0084
Brugia malayi AMP-binding enzyme family protein 0.0119 0.0273 0.1909
Schistosoma mansoni bromodomain containing 0.0007 0.0003 0.0019
Echinococcus granulosus Niemann Pick C1 protein 0.06 0.1433 0.6977
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0132 0.091
Brugia malayi transcription factor E74 isoform 0.0011 0.0012 0.0087
Trichomonas vaginalis hypothetical protein 0.0007 0.0003 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0012 0.0012
Brugia malayi hypothetical protein 0.0021 0.0036 0.0254
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.06 0.1433 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0035 0.0071 0.0475
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.001 0.0071
Brugia malayi Patched related family protein 10 0.0036 0.0074 0.0518
Trypanosoma brucei ISWI complex protein 0.0016 0.0025 0.0259
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0116 0.0265 0.1292
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Brugia malayi DKFZp564C0469 protein 0.004 0.0082 0.0573
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.004 0.0082 0.0573
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Plasmodium falciparum replication factor C subunit 1, putative 0.004 0.0082 0.4004
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0024 0.0244
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.0117 0.5746
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0209 0.1461
Brugia malayi steroid hormone receptor 0.0011 0.0012 0.0084
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0112 0.0258 0.1799
Loa Loa (eye worm) hypothetical protein 0.0089 0.0201 0.1402
Brugia malayi topoisomerase 0.004 0.0082 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0012 0.0012
Brugia malayi RNA binding protein 0.0063 0.0138 0.0962
Brugia malayi TAR-binding protein 0.0063 0.0138 0.0962
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.01 0.0682
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0039 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0403 0.4633
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.0265 0.4054
Brugia malayi Patched related family protein 4 0.0036 0.0074 0.0518
Echinococcus multilocularis neuropeptide s receptor 0.056 0.1338 0.1338
Entamoeba histolytica hypothetical protein 0.0287 0.0678 0.4721
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Loa Loa (eye worm) hypothetical protein 0.0148 0.0343 0.2397
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0071 0.0494
Plasmodium vivax hypothetical protein, conserved 0.0007 0.0003 0.00000016256
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.002
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0006 0.0002 0.0002
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.003 0.0144
Trichomonas vaginalis bromodomain containing protein, putative 0.0007 0.0003 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0108 0.0742
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0077 0.0077
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0012 0.0087
Brugia malayi Patched family protein 0.0036 0.0074 0.0518
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0138 0.0947
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0012 0.0012
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0012 0.0083
Leishmania major 4-coumarate:coa ligase-like protein 0.0119 0.0273 0.3134
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0119 0.0273 0.6022
Echinococcus granulosus c src tyrosine kinase 0.0006 0.0002 0.0008
Schistosoma mansoni tyrosine kinase 0.0006 0.0002 0.0012
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0065 0.0089
Schistosoma mansoni smad1 5 8 and 0.001 0.001 0.007
Onchocerca volvulus 0.0035 0.0071 0.1141
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0138 0.0947
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.01 0.3715
Brugia malayi hypothetical protein 0.0038 0.0079 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Schistosoma mansoni inositol monophosphatase 0.0045 0.0094 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0078 0.1266
Loa Loa (eye worm) hypothetical protein 0.004 0.0082 0.0573
Schistosoma mansoni hypothetical protein 0.0248 0.0585 0.4019
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0035 0.0071 0.1145
Toxoplasma gondii hypothetical protein 0.0036 0.0074 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Brugia malayi Bromodomain containing protein 0.0007 0.0003 0.002
Schistosoma mansoni lipoxygenase 0.0124 0.0285 0.1957
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0078 0.1266
Echinococcus multilocularis Bromodomain containing protein 0.0007 0.0003 0.0003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0054 0.0376
Onchocerca volvulus 0.0253 0.0598 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0154 0.0358 0.1745
Schistosoma mansoni hypothetical protein 0.0011 0.0012 0.0086
Brugia malayi Fli-1 protein 0.0225 0.053 0.3698
Loa Loa (eye worm) hypothetical protein 0.0285 0.0674 0.47
Brugia malayi Calcitonin receptor-like protein seb-1 0.0164 0.0383 0.2675
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0012 0.0087
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0244
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0089 0.0201 0.1402
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0287 0.0678 0.7818
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0108 0.0108
Echinococcus granulosus protein kinase C binding protein 1 0.0007 0.0003 0.0014
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0012 0.0083
Echinococcus granulosus tyrosine protein kinase Fyn 0.0006 0.0002 0.0008
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.003 0.0204
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0012 0.0061
Schistosoma mansoni helicase 0.0007 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0084
Leishmania major 4-coumarate:coa ligase-like protein 0.0119 0.0273 0.3134
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0071 0.1145
Mycobacterium ulcerans hypothetical protein 0.0119 0.0273 0.6022
Schistosoma mansoni loxhd1 0.0021 0.0036 0.025
Brugia malayi hypothetical protein 0.0478 0.114 0.7956
Loa Loa (eye worm) hypothetical protein 0.0011 0.0012 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0012 0.0084
Echinococcus granulosus CREB binding protein 0.0007 0.0003 0.0014
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus multilocularis PH interacting protein 0.0007 0.0003 0.0003
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0138 0.0962
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.0866 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Echinococcus multilocularis CREB binding protein 0.0007 0.0003 0.0003
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0035 0.0071 0.1451
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0082 0.1237
Brugia malayi Ets-domain containing protein 0.0011 0.0012 0.0087
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0054 0.0117 0.0164
Onchocerca volvulus 0.0032 0.0065 0.1042
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.0234 0.1607
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0012 0.0087
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0518
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0012 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0003 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.003 0.0204
Echinococcus granulosus tar DNA binding protein 0.0063 0.0138 0.0671
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.2888 0.6953 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0035 0.0071 0.3429
Brugia malayi hypothetical protein 0.004 0.0082 0.0573
Echinococcus granulosus Niemann Pick C1 protein 0.0857 0.2054 1
Brugia malayi hypothetical protein 0.0021 0.0036 0.0254
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0042 0.0089 0.0124
Trypanosoma cruzi FHA domain containing protein, putative 0.004 0.0082 0.0919
Trichomonas vaginalis bromodomain-containing protein, putative 0.0007 0.0003 0.0016
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0119 0.0273 0.6022
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0012 0.0084
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.011 0.1244
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0012 0.0012
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0078 0.1266
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0035 0.0071 0.0787
Schistosoma mansoni hypothetical protein 0.0052 0.0112 0.077
Brugia malayi bromodomain containing protein 0.0007 0.0003 0.002
Brugia malayi AMP-binding enzyme family protein 0.0119 0.0273 0.1909

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.9285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.8876 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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