Detailed information for compound 1400402

Basic information

Technical information
  • TDR Targets ID: 1400402
  • Name: 8-(azepan-1-yl)-3-methyl-7-(naphthalen-1-ylme thyl)purine-2,6-dione
  • MW: 403.477 | Formula: C23H25N5O2
  • H donors: 1 H acceptors: 3 LogP: 3.89 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1[nH]c(=O)n(c2c1n(Cc1cccc3c1cccc3)c(n2)N1CCCCCC1)C
  • InChi: 1S/C23H25N5O2/c1-26-20-19(21(29)25-23(26)30)28(22(24-20)27-13-6-2-3-7-14-27)15-17-11-8-10-16-9-4-5-12-18(16)17/h4-5,8-12H,2-3,6-7,13-15H2,1H3,(H,25,29,30)
  • InChiKey: CESMWOZTTPHJPX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-(azepan-1-yl)-3-methyl-7-(1-naphthylmethyl)purine-2,6-dione
  • 8-(1-azepanyl)-3-methyl-7-(1-naphthylmethyl)purine-2,6-dione
  • 8-(azepan-1-yl)-3-methyl-7-(1-naphthylmethyl)xanthine
  • MLS000081300
  • SMR000045521
  • ZINC04039293

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0068 0.0593 0.214
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.036
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.1887
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0031 0.0241 0.0095
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0368 0.0198
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0068 0.0593 0.0575
Leishmania major phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.0427
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0356 0.0338
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0356 0.0763
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0283 0.2623 0.2623
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.0068 0.0593 0.0593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0593 0.0575
Trichomonas vaginalis PIKK family atypical protein kinase 0.0572 0.5366 0.5357
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0052 0.0052
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.0604 0.0595
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0356 0.0763
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Onchocerca volvulus Huntingtin homolog 0.0148 0.1347 0.6729
Loa Loa (eye worm) hypothetical protein 0.0155 0.1414 0.1414
Schistosoma mansoni hypothetical protein 0.0019 0.0125 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0573 0.5374 0.5365
Loa Loa (eye worm) CYP4Cod1 0.0084 0.0739 0.0739
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Onchocerca volvulus 0.0033 0.0253 0.007
Entamoeba histolytica hypothetical protein 0.0068 0.0593 0.036
Echinococcus granulosus neuropeptide s receptor 0.056 0.5257 0.5257
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0593 0.0593
Echinococcus multilocularis neuropeptide s receptor 0.056 0.5257 0.5257
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0228 0.2104 0.1909
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0052 0.0052
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0046 0.0046
Brugia malayi follicle stimulating hormone receptor 0.0283 0.2623 0.2623
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0068 0.0593 0.0593
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0368 0.0198
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0228 0.2104 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0068 0.0593 0.0593
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1884 0.1869
Echinococcus granulosus voltage gated potassium channel 0.0015 0.0088 0.0088
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.7942 0.7939
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0367 0.0198
Echinococcus granulosus cytochrome P450 2K1 0.0024 0.0173 0.0173
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0367 0.0198
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0639 0.2415
Schistosoma mansoni lamin 0.0033 0.0253 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0627 0.5893 0.5886
Leishmania major hypothetical protein, unknown function 0.0068 0.0593 0.0427
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0228 0.2104 0.2104
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.0593 0.0593
Entamoeba histolytica hypothetical protein 0.0201 0.1846 0.1644
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0068 0.0593 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.1846 0.1831
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0228 0.2104 0.1966
Loa Loa (eye worm) acetyltransferase 0.016 0.1461 0.1461
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0368 0.0368
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0368 0.0368
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0052 0.0052
Trypanosoma cruzi cytochrome P450, putative 0.0084 0.0739 0.0576
Schistosoma mansoni hypothetical protein 0.0031 0.0241 0.0241
Echinococcus granulosus intermediate filament protein 0.0033 0.0253 0.0253
Brugia malayi MH2 domain containing protein 0.0009 0.0029 0.0029
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0052 0.0052
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0031 0.0241 0.007
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0201 0.1846 0.1846
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0356 0.0356
Brugia malayi Inositol-1 0.0045 0.0367 0.0367
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0356 0.095
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0228 0.2104 0.209
Mycobacterium tuberculosis Conserved protein 0.0043 0.0356 0.0763
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.039 0.0372
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0052 0.0052
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Loa Loa (eye worm) phosphatidylinositol kinase 0.0068 0.0593 0.0593
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0068 0.0593 0.0593
Loa Loa (eye worm) phosphatidylinositol 3 0.0356 0.3316 0.3316
Trichomonas vaginalis fk506 binding protein, putative 0.0031 0.0241 0.0223
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0068 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0043 0.0356 0.0356
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0844 0.7951 0.7915
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0356 0.0356
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0313 0.0295
Schistosoma mansoni fk506 binding protein 0.0031 0.0241 0.0241
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0093 0.0093
Echinococcus multilocularis neuropeptide receptor A26 0.056 0.5257 0.5257
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.0739 0.0739
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0068 0.0593 0.1887
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0109 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2901 0.2888
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0228 0.2104 0.2104
Brugia malayi MH2 domain containing protein 0.0009 0.0029 0.0029
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0132 0.1197 0.1042
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0201 0.1846 0.1846
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0084 0.0739 0.2932
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.1461 0.1461
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0368 0.0368
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0593 0.0593
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0228 0.2104 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.0593 0.0593
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0356 0.3316 0.3316
Schistosoma mansoni lamin 0.0033 0.0253 0.0253
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0068 0.0593 0.0593
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0356 0.3316 0.3199
Plasmodium vivax hypothetical protein, conserved 0.0068 0.0593 0.1887
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0068 0.0593 0.0575
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0026 0.0026
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0068 0.0593 0.0427
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.1414 0.1398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0688 0.6472 0.6466
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0015 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0043 0.0356 0.0356
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0228 0.2104 0.209
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0228 0.2104 0.1909
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0068 0.0593 0.0593
Echinococcus granulosus Smad4 0.0009 0.0029 0.0029
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0068 0.0593 0.1887
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0068 0.0593 0.0427
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.1461 0.1461
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0029 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0627 0.5893 0.5886
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0125 0.0125
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0026 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2901 0.2888
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0125 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.3316 0.3304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.1846 0.1831
Brugia malayi FAT domain containing protein 0.0155 0.1414 0.1414
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0052 0.0052
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0356 0.3316 0.3316
Schistosoma mansoni cpg binding protein 0.0037 0.0292 0.0292
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0068 0.0593 0.1887
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.3316 0.3304
Onchocerca volvulus 0.0043 0.0356 0.07
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0052 0.0033
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.0427
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0201 0.1846 0.1703
Entamoeba histolytica hypothetical protein 0.0043 0.0356 0.0117
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0031 0.0241 0.007
Schistosoma mansoni fkbp-rapamycin associated protein 0.0201 0.1846 0.1846
Onchocerca volvulus 0.0043 0.0356 0.07
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0031 0.0241 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0639 0.2415
Schistosoma mansoni intermediate filament proteins 0.0033 0.0253 0.0253
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.0427
Brugia malayi MH1 domain containing protein 0.0009 0.0029 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0711 0.6689 0.6683
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0353 0.0599
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0125 0.0125
Trypanosoma brucei cytochrome P450, putative 0.0084 0.0739 0.0576
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0368 0.0198
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0029 0.0029
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0228 0.2104 0.1966
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0367 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.7423 0.7418
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0087
Brugia malayi Cytochrome P450 family protein 0.0084 0.0739 0.0739
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0196 0.1807 0.1807
Entamoeba histolytica hypothetical protein 0.0043 0.0356 0.0117
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0356 0.0356
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.0575
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.7423 0.7418
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0068 0.0593 0.036
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0228 0.2104 0.1966
Brugia malayi intermediate filament protein 0.0033 0.0253 0.0253
Echinococcus granulosus cpg binding protein 0.0037 0.0292 0.0292
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0368 0.0129
Brugia malayi MH1 domain containing protein 0.0009 0.0029 0.0029
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0368 0.0368
Schistosoma mansoni smad1 5 8 and 0.0009 0.0029 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.7942 0.7939
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0125 0.0125
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0201 0.1846 0.1846
Trichomonas vaginalis PIKK family atypical protein kinase 0.0201 0.1846 0.1831
Loa Loa (eye worm) hypothetical protein 0.0132 0.1197 0.1197
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0639 0.0639
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0068 0.0593 0.1887
Loa Loa (eye worm) hypothetical protein 0.0031 0.0241 0.0241
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2901 0.2888
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0593 0.0593
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0068 0.0593 0.0593
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0228 0.2104 1
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0068 0.0593 0.0593
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0029 0.0029
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0068 0.0593 0.0575
Schistosoma mansoni immunophilin 0.0228 0.2104 0.2104
Mycobacterium leprae Probable lipase LipE 0.0043 0.0356 0.4368
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0068 0.0593 0.0593
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0031 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0216 0.1993 0.1993
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0273 0.0273
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0031 0.0241 0.0241
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0068 0.0593 0.0575
Brugia malayi hypothetical protein 0.0148 0.1347 0.1347
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0011 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0045 0.0368 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0368 0.035
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0323 0.3567
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0515 0.0515
Leishmania major phosphatidylinositol kinase related protein, putative 0.0068 0.0593 0.0427
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0031 0.0241 0.0241
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0405 0.0405
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.039 0.039
Echinococcus multilocularis lamin dm0 0.0033 0.0253 0.0253
Brugia malayi Cytochrome P450 family protein 0.0084 0.0739 0.0739
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0368 0.0368
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0068 0.0593 0.036
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0639 0.0643
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0155 0.1414 0.1414
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.2901 0.2901
Echinococcus granulosus GPCR family 2 0.0019 0.0125 0.0125
Mycobacterium tuberculosis Conserved protein 0.0043 0.0356 0.0763
Schistosoma mansoni smad 0.0009 0.0029 0.0029
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.1887
Onchocerca volvulus Huntingtin homolog 0.0148 0.1347 0.6729
Plasmodium vivax hypothetical protein 0.0068 0.0593 0.1887
Trichomonas vaginalis PIKK family atypical protein kinase 0.0905 0.853 0.8527
Onchocerca volvulus 0.0035 0.0273 0.0192
Schistosoma mansoni hypothetical protein 0.0019 0.0125 0.0125
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0031 0.0241 0.0241
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0201 0.1846 0.1703
Brugia malayi CXXC zinc finger family protein 0.0035 0.0273 0.0273
Trichomonas vaginalis esterase, putative 0.0043 0.0356 0.0338
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0353 0.0114
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0334 0.0334
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4627 0.4627
Echinococcus multilocularis Smad4 0.0009 0.0029 0.0029
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0285 0.2642 0.2628
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0356 0.0356
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0068 0.0593 0.0427
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0367 0.0268
Echinococcus multilocularis fk506 binding protein 0.0228 0.2104 0.2104
Leishmania major phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.0427
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0068 0.0593 0.0593
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0367 0.0349
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0353 0.0114
Echinococcus granulosus lamin 0.0033 0.0253 0.0253
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0368 0.0368
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0011 0.0052 0.0052
Leishmania major peptidylprolyl isomerase-like protein 0.0228 0.2104 0.1966
Loa Loa (eye worm) hypothetical protein 0.0043 0.0356 0.0356
Schistosoma mansoni immunophilin 0.0196 0.1807 0.1807
Leishmania major phosphatidylinositol 3-kinase, putative 0.0356 0.3316 0.3199
Trypanosoma cruzi target of rapamycin kinase 3 0.0844 0.7951 0.7915
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.1194 0.1194
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0068 0.0593 0.0575
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0356 0.0763
Schistosoma mansoni 60S ribosomal protein L21 0.001 0.0036 0.0036
Echinococcus multilocularis cpg binding protein 0.0037 0.0292 0.0292
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0015 0.0088 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0224 0.2063 0.2048
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0593 0.0593
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0356 0.3316 0.3199
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0356 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0132 0.1197 0.1181
Leishmania major fk506-binding protein 1-like protein 0.0228 0.2104 0.1966
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1884 0.1869
Loa Loa (eye worm) hypothetical protein 0.006 0.051 0.051
Loa Loa (eye worm) cytochrome P450 0.0024 0.0173 0.0173
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.036
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0068 0.0593 0.0575
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0068 0.0593 0.0593
Echinococcus multilocularis musashi 0.0033 0.0253 0.0253
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1884 0.1869
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0201 0.1846 0.1703
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0356 0.3316 0.3199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0573 0.5374 0.5365
Echinococcus multilocularis 0.0068 0.0593 0.0593
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0031 0.0241 0.0241
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0368 0.0368
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0068 0.0593 0.0593
Schistosoma mansoni hypothetical protein 0.0019 0.0125 0.0125
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0046 0.0046
Brugia malayi beta-lactamase family protein 0.0043 0.0356 0.0356
Trichomonas vaginalis fk506-binding protein, putative 0.0228 0.2104 0.209
Schistosoma mansoni smad1 5 8 and 0.0009 0.0029 0.0029
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0356 0.0763
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0068 0.0593 0.0593
Schistosoma mansoni smad1 5 8 and 0.0009 0.0029 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.3316 0.3304
Loa Loa (eye worm) FKBP5 protein 0.0228 0.2104 0.2104
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0068 0.0593 0.0575
Loa Loa (eye worm) hypothetical protein 0.0032 0.0247 0.0247
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1884 0.1869
Entamoeba histolytica hypothetical protein 0.0068 0.0593 0.036
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1884 0.1869
Loa Loa (eye worm) hypothetical protein 0.0043 0.0356 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.7423 0.7418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0572 0.5366 0.5357
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0052 0.0052
Echinococcus multilocularis 0.0024 0.0173 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.0593 0.0575
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0515 0.0515
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0052 0.0052
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0368 0.0368
Loa Loa (eye worm) Smad1 0.0009 0.0029 0.0029
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0036 0.0036
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0356 0.0187
Schistosoma mansoni cytochrome P450 0.0024 0.0173 0.0173
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0109 0.0109
Trichomonas vaginalis fk506-binding protein, putative 0.0031 0.0241 0.0223
Mycobacterium leprae conserved hypothetical protein 0.0068 0.0593 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0356 0.0617
Trichomonas vaginalis immunophilin, putative 0.0228 0.2104 0.209
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0356 0.0763
Mycobacterium ulcerans hypothetical protein 0.0031 0.0241 0.0355
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0068 0.0593 0.0575
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0642 0.0642
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0068 0.0593 0.036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0356 0.0356
Schistosoma mansoni Smad4 0.0009 0.0029 0.0029
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0368 0.0368
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0011 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0043 0.0356 0.0356
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0367 0.1005
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0029 0.0029
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.2901 0.2901
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0228 0.2104 0.1966
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.3316 0.3304
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0356 0.3316 0.3199
Echinococcus multilocularis Zinc finger, PHD finger 0.0068 0.0593 0.0593
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.039 0.0799
Entamoeba histolytica hypothetical protein 0.0068 0.0593 0.036
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0253 0.0253
Brugia malayi beta-lactamase 0.0043 0.0356 0.0356
Echinococcus granulosus FK506 binding protein 2 0.0031 0.0241 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0572 0.5366 0.5357
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1989 0.1974
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.1887
Mycobacterium tuberculosis Conserved hypothetical protein 0.0068 0.0593 0.1746
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0068 0.0593 0.0593
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0068 0.0593 0.0579
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0031 0.0241 0.0095
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0367 0.0129
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0068 0.0593 0.0593
Mycobacterium ulcerans beta-lactamase 0.0043 0.0356 0.095
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0323 0.0623
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0228 0.2104 0.1966
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0031 0.0241 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.1197 0.1181
Echinococcus multilocularis smad 0.0009 0.0029 0.0029
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0031 0.0241 0.0285
Entamoeba histolytica protein kinase rad3, putative 0.0201 0.1846 0.1644
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0844 0.7951 0.7915
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0068 0.0593 0.0579
Loa Loa (eye worm) hypothetical protein 0.0039 0.0316 0.0316
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0356 0.0338
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0068 0.0593 0.0593
Schistosoma mansoni hypothetical protein 0.0155 0.1414 0.1414
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0356 0.0356
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0031 0.0241 0.0241
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0405 0.0405
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0068 0.0593 0.0575
Loa Loa (eye worm) hypothetical protein 0.0148 0.1347 0.1347
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.036
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0052 0.0052
Schistosoma mansoni inositol monophosphatase 0.0045 0.0367 0.0367
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0639 0.0639
Brugia malayi Cyclic-nucleotide gated cation channel 0.0011 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.7942 0.7939
Loa Loa (eye worm) hypothetical protein 0.0033 0.0253 0.0253
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.0427
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2901 0.2888
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0052 0.0052
Echinococcus granulosus serine protein kinase ATM 0.0201 0.1846 0.1846
Mycobacterium tuberculosis Conserved protein 0.0043 0.0356 0.0763
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0241 0.0223
Brugia malayi Cytochrome P450 family protein 0.0024 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0041 0.0334 0.0334
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0634 0.5953 0.5945
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.1418 0.1418
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0201 0.1846 0.1846
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0068 0.0593 0.0579
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.0427
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.039 0.03
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0253 0.0253
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0015 0.0088 0.0088
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.0593 0.0593
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0368 0.0198
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0639 0.0639
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0639 0.0639
Trichomonas vaginalis PIKK family atypical protein kinase 0.0634 0.5953 0.5945
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0029 0.0029
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0029 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1884 0.1869
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.1194 0.1194
Leishmania major hypothetical protein, conserved 0.0068 0.0593 0.0427
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.0427
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0068 0.0593 0.0575
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0052 0.0052
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0356 0.0763
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0356 0.0356
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.039 0.0372
Toxoplasma gondii FATC domain-containing protein 0.0201 0.1846 0.2308
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.039 0.03
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.9229 0.9229
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0593 0.0593
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0068 0.0593 0.0575
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0052 0.0033
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0253 0.0253
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0502 0.47 0.4606
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0011 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.7423 0.7418
Echinococcus multilocularis lamin 0.0033 0.0253 0.0253
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0356 0.0338
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0125 0.0125
Echinococcus multilocularis 0.0031 0.0241 0.0241
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0228 0.2104 0.2104
Echinococcus multilocularis voltage gated potassium channel 0.0015 0.0088 0.0088
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0228 0.2104 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0368 0.0368
Giardia lamblia Hypothetical protein 0.0068 0.0593 0.036
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0368 0.0368
Brugia malayi Cytochrome P450 family protein 0.0024 0.0173 0.0173
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0356 0.0338
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0356 0.3316 0.3199
Echinococcus granulosus neuropeptide receptor A26 0.056 0.5257 0.5257
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0052 0.0052
Echinococcus granulosus smad 0.0009 0.0029 0.0029
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0196 0.1807 0.1807
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0356 0.3316 0.3316
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Schistosoma mansoni cpg binding protein 0.0037 0.0292 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0573 0.5374 0.5365
Loa Loa (eye worm) hypothetical protein 0.0015 0.0087 0.0087
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0593 0.0593
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0068 0.0593 0.0593
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0068 0.0593 0.0579
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0029 0.0029
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0068 0.0593 0.0427
Onchocerca volvulus 0.0043 0.0356 0.07
Mycobacterium ulcerans hypothetical protein 0.0043 0.0356 0.095
Brugia malayi hypothetical protein 0.0043 0.0356 0.0356
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0031 0.0241 0.007
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0088 0.0088
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0367 0.0349
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0031 0.0241 0.0095
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0241 0.007
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0068 0.0593 0.0579
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0125 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.7423 0.7418
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0241 0.0223
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0367 0.0198
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0356 0.0187
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0125 0.0125
Trypanosoma cruzi cytochrome P450, putative 0.0084 0.0739 0.0576
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0068 0.0593 0.0593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.7942 0.7939
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0031 0.0241 0.1631
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0356 0.0763
Schistosoma mansoni inositol monophosphatase 0.0045 0.0367 0.0367
Entamoeba histolytica hypothetical protein 0.0043 0.0356 0.0117
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0011 0.0052 0.0052
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0356 0.0338
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0068 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0043 0.0356 0.0356
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0068 0.0593 0.0427
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0068 0.0593 0.0427
Brugia malayi cytochrome P450 0.0024 0.0173 0.0173
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0368 0.035
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0068 0.0593 0.0427
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0026 0.0026
Onchocerca volvulus 0.0033 0.0253 0.007
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0228 0.2104 0.2104
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0196 0.1807 0.1807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.7423 0.7418
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2901 0.2888
Leishmania major hypothetical protein, conserved 0.0043 0.0356 0.0187
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0368 0.0129
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0313 0.0295
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0173 0.0173
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0356 0.3316 0.3316
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.0593 0.0593
Echinococcus granulosus lamin dm0 0.0033 0.0253 0.0253
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0201 0.1846 0.1846
Trichomonas vaginalis fk506-binding protein, putative 0.0031 0.0241 0.0223
Toxoplasma gondii ABC1 family protein 0.0043 0.0356 0.0253
Loa Loa (eye worm) inositol-1 0.0045 0.0367 0.0367
Leishmania major phosphatidylinositol kinase, putative 0.0068 0.0593 0.0427
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0228 0.2104 0.2104
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0068 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.006 0.0515 0.0515
Loa Loa (eye worm) beta-lactamase 0.0043 0.0356 0.0356
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0031 0.0241 0.0241
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0068 0.0593 0.0593
Giardia lamblia Phosphatidylinositol 4-kinase 0.0068 0.0593 0.036
Loa Loa (eye worm) hypothetical protein 0.0224 0.2063 0.2063
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0228 0.2104 0.2104
Schistosoma mansoni hypothetical protein 0.0019 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0068 0.0593 0.0593
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0201 0.1846 0.1846
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0228 0.2104 0.1909
Trichomonas vaginalis PIKK family atypical protein kinase 0.0573 0.5374 0.5365
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0441 0.4121 0.4017
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0224 0.2063 0.2607
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0068 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0148 0.1347 0.1347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0634 0.5953 0.5945
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0356 0.0187
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0043 0.0356 0.0117
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.1461 0.1461
Schistosoma mansoni hypothetical protein 0.0024 0.0173 0.0173
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0155 0.1414 0.1414
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0068 0.0593 0.036
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0356 0.095
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0125
Toxoplasma gondii target of rapamycin (TOR), putative 0.0789 0.7423 1
Brugia malayi MH2 domain containing protein 0.0132 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0015 0.0088 0.0088
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0367 0.0367
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.0739 0.0739
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1884 0.1869
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0639 0.194
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0068 0.0593 0.0427
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4627 0.4627
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0026 0.0026
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0045 0.0045
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0088 0.0088
Echinococcus multilocularis serine protein kinase ATM 0.0201 0.1846 0.1846
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.036
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.1884 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0228 0.2104 0.1909
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0356 0.0356
Schistosoma mansoni hypothetical protein 0.0494 0.4627 0.4627
Brugia malayi beta-lactamase family protein 0.0043 0.0356 0.0356
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0367 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0031 0.0241 0.0241
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0639 0.2415
Onchocerca volvulus 0.0068 0.0593 0.214
Schistosoma mansoni cpg binding protein 0.0035 0.0273 0.0273
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1989 0.1974
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0228 0.2104 0.1966
Trichomonas vaginalis PIKK family atypical protein kinase 0.0789 0.7423 0.7418
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0068 0.0593 0.0593
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0368 0.035
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0068 0.0593 0.036
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0367 0.0198
Brugia malayi Smad1 0.0009 0.0029 0.0029
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0228 0.2104 0.2104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0844 0.7942 0.7939
Mycobacterium ulcerans lipase LipD 0.0043 0.0356 0.095
Schistosoma mansoni immunophilin 0.0228 0.2104 0.2104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0356 0.3316 0.3304
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0639 0.0475
Loa Loa (eye worm) hypothetical protein 0.0068 0.0593 0.0593
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0515 0.0515
Schistosoma mansoni hypothetical protein 0.0043 0.0356 0.0356
Leishmania major cytochrome p450-like protein 0.0084 0.0739 0.0576
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0201 0.1846 0.1644
Entamoeba histolytica hypothetical protein 0.0068 0.0593 0.036
Loa Loa (eye worm) phosphatidylinositol 3 0.0068 0.0593 0.0593
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0068 0.0593 0.036
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0031 0.0241 0.007
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0068 0.0593 0.0575
Echinococcus multilocularis GPCR, family 2 0.0019 0.0125 0.0125
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2578 1
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0356 0.4368
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0367 0.0367
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0052 0.0052
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2901 0.2888
Schistosoma mansoni hypothetical protein 0.0041 0.0334 0.0334
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0068 0.0593 0.0427

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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