TDR Targets

Basic information

Technical information

TDR Targets ID: 1401456
Name: N-[(2,4-dimethoxyphenyl)methyl]-2-(3-methoxyp henyl)pyrimidin-4-amine
MW: 351.399 | Formula: C20H21N3O3
H donors: 1 H acceptors: 2 LogP: 3.59 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1)OC)CNc1ccnc(n1)c1cccc(c1)OC
InChi: 1S/C20H21N3O3/c1-24-16-6-4-5-14(11-16)20-21-10-9-19(23-20)22-13-15-7-8-17(25-2)12-18(15)26-3/h4-12H,13H2,1-3H3,(H,21,22,23)
InChiKey: RULIAUGJMVIUMH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(2,4-dimethoxyphenyl)methyl]-2-(3-methoxyphenyl)-4-pyrimidinamine
(2,4-dimethoxybenzyl)-[2-(3-methoxyphenyl)pyrimidin-4-yl]amine
NCGC00010689
PCOP-229775

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cytochrome P450, family 1, subfamily A, polypeptide 2	Starlite/ChEMBL	No references
Homo sapiens	cytochrome P450, family 2, subfamily D, polypeptide 6	Starlite/ChEMBL	No references
Homo sapiens	cytochrome P450, family 3, subfamily A, polypeptide 4	Starlite/ChEMBL	No references
Homo sapiens	glucosidase, beta, acid	Starlite/ChEMBL	No references
Homo sapiens	cytochrome P450, family 2, subfamily C, polypeptide 19	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma congolense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania infantum	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Candida albicans	cytochrome P450 556	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126582	All targets in OG5_126582
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania major	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Brugia malayi	O-Glycosyl hydrolase family 30 protein	Get druggable targets OG5_129423	All targets in OG5_129423
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania mexicana	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	CYP4Cod1	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma brucei	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Candida albicans	cytochrome P450 56	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania braziliensis	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Onchocerca volvulus	Glucosylceramidase homolog	Get druggable targets OG5_129423	All targets in OG5_129423
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania donovani	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	Get druggable targets OG5_129423	All targets in OG5_129423
Trypanosoma brucei gambiense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Cytochrome P450 family protein	cytochrome P450, family 1, subfamily A, polypeptide 2	516 aa	470 aa	26.2 %
Brugia malayi	cytochrome P450	cytochrome P450, family 2, subfamily D, polypeptide 6	497 aa	425 aa	32.0 %
Leishmania major	cytochrome p450-like protein	cytochrome P450, family 2, subfamily C, polypeptide 19	490 aa	411 aa	23.1 %
Brugia malayi	cytochrome P450	cytochrome P450, family 3, subfamily A, polypeptide 4	502 aa	492 aa	24.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	myotubularin protein 13	0.0046	0.0061	0.0054
Brugia malayi	Syntrophin-1	0.0046	0.0061	0.0061
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0042	0.0047	0.334
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0046	0.0061	0.0061
Schistosoma mansoni	plexin	0.0336	0.0995	0.0981
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.2616	0.8364	0.8364
Echinococcus granulosus	serine/threonine protein kinase	0.0059	0.0102	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0042	0.0047	0.0037
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0046	0.0061	0.0054
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0042	0.0047	0.0037
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0059	0.0102	0.0365
Brugia malayi	hypothetical protein	0.0042	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0047	0.0047
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0042	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0282	0.0282
Echinococcus multilocularis	plexin a4	0.0695	0.2158	0.2566
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0061	0.4325
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Echinococcus granulosus	oxysterol binding protein 1	0.0046	0.0061	0.0054
Echinococcus multilocularis	epidermal growth factor receptor	0.0042	0.0047	0.0037
Echinococcus granulosus	tyrosine protein kinase pr2	0.0042	0.0047	0.0037
Onchocerca volvulus		0.0042	0.0047	0.0185
Echinococcus granulosus	epidermal growth factor receptor	0.0042	0.0047	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	TK family protein kinase	0.0042	0.0047	0.0149
Brugia malayi	Cadps2 protein	0.0046	0.0061	0.0061
Schistosoma mansoni	protein kinase	0.0042	0.0047	0.0031
Brugia malayi	hypothetical protein	0.0506	0.1546	0.1546
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0282	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0506	0.1546	0.1546
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0046	0.0061	0.0045
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0046	0.0061	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.0265	0.1582
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0042	0.0047	0.0047
Brugia malayi	PH domain containing protein	0.0046	0.0061	0.0061
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0042	0.0047	0.0047
Loa Loa (eye worm)	syntrophin-1	0.0046	0.0061	0.0061
Brugia malayi	PH domain containing protein	0.0046	0.0061	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.0265	0.1582
Echinococcus granulosus	tyrosine protein kinase shark	0.0042	0.0047	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0046	0.0061	0.0054
Echinococcus multilocularis	tyrosine kinase	0.0042	0.0047	0.0037
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0047	0.0062	0.0055
Brugia malayi	Cytohesin 3	0.0046	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Brugia malayi	DNA-binding protein LAG-1	0.011	0.0265	0.0265
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0047	0.0037
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.0918	0.5875
Brugia malayi	PXA domain containing protein	0.0506	0.1546	0.1546
Schistosoma mansoni	axis inhibition protein axin	0.0506	0.1546	0.1533
Loa Loa (eye worm)	TK/ACK protein kinase	0.0042	0.0047	0.0047
Entamoeba histolytica	protein kinase domain containing protein	0.0055	0.0088	0.0273
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0046	0.0061	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Schistosoma mansoni	regulator of G protein signaling	0.0506	0.1546	0.1533
Onchocerca volvulus	Putative zinc finger protein	0.0046	0.0061	0.0262
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.1887	0.6009	0.7178
Leishmania major	serine/threonine-protein kinase a, putative	0.0059	0.0102	0.7243
Echinococcus multilocularis	tyrosine protein kinase	0.0042	0.0047	0.0037
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.0918	0.5875
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0115	0.0282	0.0319
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.011	0.0265	0.1582
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0046	0.0061	0.024
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0042	0.0047	0.0037
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.0572	0.3599
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0047	0.0149
Echinococcus granulosus	activin receptor type	0.0055	0.0088	0.0086
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.0572	0.3599
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0046	0.0061	0.024
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.014	0.0763
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0046	0.0061	0.0054
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0042	0.0047	0.0037
Schistosoma mansoni	regulator of G protein signaling	0.0506	0.1546	0.1533
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.0918	0.5875
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0042	0.0047	0.0037
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0059	0.0102	0.0365
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0059	0.0102	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0047
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Echinococcus granulosus	Rho GTPase activating protein 24	0.0046	0.0061	0.0054
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.011	0.0265	0.1582
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0047	0.0037
Entamoeba histolytica	cell surface protease gp63, putative	0.011	0.0265	0.1454
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0055	0.0088	0.438
Brugia malayi	IPT/TIG domain containing protein	0.011	0.0265	0.0265
Brugia malayi	C-terminal src kinase protein 1	0.0042	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.025	0.0719	0.0719
Entamoeba histolytica	protein kinase, putative	0.0059	0.0102	0.0365
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0047	0.0047
Schistosoma mansoni	hypothetical protein	0.0336	0.0995	0.0981
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.011	0.0265	0.1582
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.0572	0.3599
Trichomonas vaginalis	centaurin beta, putative	0.0046	0.0061	0.024
Leishmania major	protein kinase, putative	0.0042	0.0047	0.334
Brugia malayi	Fibronectin type III domain containing protein	0.012	0.0297	0.0297
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Schistosoma mansoni	protein kinase	0.0055	0.0088	0.0072
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0042	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Echinococcus granulosus	DCC interacting protein 13 beta	0.0046	0.0061	0.0054
Trypanosoma cruzi	hypothetical protein	0.0046	0.0061	0.4325
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0042	0.0047	0.0031
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.014	0.0763
Brugia malayi	Plekhf2 protein	0.0046	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Schistosoma mansoni	zinc finger protein	0.0046	0.0061	0.0045
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0042	0.0047	0.0185
Brugia malayi	plexin A	0.0695	0.2158	0.2158
Trypanosoma cruzi	protein kinase, putative	0.0042	0.0047	0.334
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Echinococcus granulosus	tyrosine protein kinase Srms	0.0042	0.0047	0.0037
Echinococcus multilocularis	neuroglian	0.0115	0.0282	0.0319
Loa Loa (eye worm)	TK/ABL protein kinase	0.0042	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Brugia malayi	probable spectrin beta chain	0.0046	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0042	0.0047	0.0037
Trypanosoma brucei	PH domain containing protein, putative	0.0046	0.0061	0.4325
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0506	0.1546	1
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0042	0.0047	0.0047
Echinococcus multilocularis	regulator of G protein signaling 7	0.0506	0.1546	0.1833
Schistosoma mansoni	ephrin receptor	0.0042	0.0047	0.0031
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0042	0.0047	0.0037
Echinococcus multilocularis	rac serine:threonine kinase	0.0059	0.0102	0.0103
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0059	0.0102	0.586
Brugia malayi	Guanylyl cyclase protein 23	0.0042	0.0047	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0047	0.0149
Echinococcus granulosus	oxysterol binding protein 3	0.0046	0.0061	0.0054
Trypanosoma brucei	Pseudokinase, putative	0.0042	0.0047	0.334
Brugia malayi	Tyrosine-protein kinase abl-1	0.0042	0.0047	0.0047
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0046	0.0061	0.0061
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Echinococcus granulosus	tyrosine kinase	0.0042	0.0047	0.0037
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0506	0.1546	0.1546
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Echinococcus multilocularis	protein kinase	0.0042	0.0047	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0042	0.0047	0.0149
Brugia malayi	PXA domain containing protein	0.0506	0.1546	0.1546
Loa Loa (eye worm)	Plekhf2 protein	0.0046	0.0061	0.0061
Echinococcus multilocularis	Oxysterol binding protein 11	0.0046	0.0061	0.0054
Toxoplasma gondii	Oxysterol-binding protein	0.0046	0.0061	0.148
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.0918	0.5875
Toxoplasma gondii	aurora kinase	0.0071	0.014	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Schistosoma mansoni	hypothetical protein	0.011	0.0265	0.0249
Onchocerca volvulus		0.0033	0.0016	0.0012
Trypanosoma cruzi	aurora B kinase, putative	0.0071	0.014	1
Brugia malayi	Variant SH3 domain containing protein	0.0046	0.0061	0.0061
Entamoeba histolytica	hypothetical protein	0.0046	0.0061	0.0092
Entamoeba histolytica	protein kinase, putative	0.0059	0.0102	0.0365
Echinococcus granulosus	neuroglian	0.0115	0.0282	0.0319
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0042	0.0047	0.0037
Echinococcus granulosus	natriuretic peptide receptor 1	0.0042	0.0047	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0042	0.0047	0.0047
Echinococcus multilocularis	beta adrenergic receptor kinase	0.2393	0.7644	0.9138
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.2616	0.8364	0.8364
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0059	0.0102	0.0365
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0047	0.0149
Schistosoma mansoni	growth factor receptor-bound protein	0.0046	0.0061	0.0045
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0046	0.0061	0.0045
Echinococcus multilocularis	tyrosine kinase	0.0042	0.0047	0.0037
Loa Loa (eye worm)	hypothetical protein	0.012	0.0297	0.0297
Trichomonas vaginalis	conserved hypothetical protein	0.0506	0.1546	1
Onchocerca volvulus	Glucosylceramidase homolog	0.0205	0.0572	0.3118
Trichomonas vaginalis	centaurin/arf, putative	0.0046	0.0061	0.024
Echinococcus multilocularis	pdz domain containing protein	0.0046	0.0061	0.0054
Loa Loa (eye worm)	TK/EPH protein kinase	0.0042	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Schistosoma mansoni	protein kinase	0.0042	0.0047	0.0031
Brugia malayi	Furin-like cysteine rich region family protein	0.0042	0.0047	0.0047
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0042	0.0047	0.0037
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0046	0.0061	0.0061
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0506	0.1546	0.1833
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0042	0.0047	0.0047
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0061	0.4325
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0042	0.0047	0.0037
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0042	0.0047	0.0037
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0046	0.0061	0.024
Schistosoma mansoni	dynamin	0.0046	0.0061	0.0045
Entamoeba histolytica	hypothetical protein	0.0506	0.1546	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0059	0.0102	0.7243
Echinococcus multilocularis	expressed protein	0.0506	0.1546	0.1833
Brugia malayi	hypothetical protein	0.025	0.0719	0.0719
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Trypanosoma cruzi	protein kinase, putative	0.0042	0.0047	0.334
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0042	0.0047	0.0037
Loa Loa (eye worm)	hypothetical protein	0.011	0.0265	0.0265
Brugia malayi	regulator of G-protein signaling egl-10	0.0506	0.1546	0.1546
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Echinococcus granulosus	Regulator of G protein signaling 20	0.0506	0.1546	0.1833
Onchocerca volvulus		0.0046	0.0061	0.0262
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0046	0.0061	0.4325
Loa Loa (eye worm)	sema domain-containing protein	0.025	0.0719	0.0719
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0059	0.0102	0.7243
Brugia malayi	PH domain containing protein	0.0046	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Echinococcus multilocularis	activin receptor type	0.0055	0.0088	0.0086
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0042	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Schistosoma mansoni	protein kinase	0.0042	0.0047	0.0031
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0046	0.0061	0.0092
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Entamoeba histolytica	hypothetical protein, conserved	0.0046	0.0061	0.0092
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0046	0.0061	0.0061
Brugia malayi	Variant SH3 domain containing protein	0.0046	0.0061	0.0061
Entamoeba histolytica	protein kinase, putative	0.0059	0.0102	0.0365
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0042	0.0047	0.0037
Echinococcus granulosus	insulin receptor	0.0042	0.0047	0.0037
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0059	0.0102	0.7243
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0042	0.0047	0.0031
Schistosoma mansoni	protein kinase	0.0042	0.0047	0.0031
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0071	0.014	0.0623
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Brugia malayi	PH domain containing protein	0.0046	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0042	0.0047	0.0037
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0042	0.0047	0.0031
Echinococcus granulosus	Oxysterol binding protein 11	0.0046	0.0061	0.0054
Echinococcus granulosus	pdz domain containing protein	0.0046	0.0061	0.0054
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0042	0.0047	0.0037
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0042	0.0047	0.0037
Brugia malayi	Dynamin	0.0046	0.0061	0.0061
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0061	0.0092
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0059	0.0102	0.7243
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0059	0.0102	0.7243
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0042	0.0047	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0061	0.0092
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0042	0.0047	0.0037
Onchocerca volvulus	Protein melted homolog	0.0046	0.0061	0.0262
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0047	0.0149
Echinococcus multilocularis	tyrosine protein kinase csk	0.0042	0.0047	0.0037
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0046	0.0061	0.024
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0046	0.0061	0.024
Echinococcus multilocularis	regulator of G protein signaling 3	0.0506	0.1546	0.1833
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0046	0.0061	0.0054
Echinococcus multilocularis	Pleckstrin y	0.0046	0.0061	0.0054
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0042	0.0047	0.0037
Echinococcus granulosus	regulator of G protein signaling 3	0.0506	0.1546	0.1833
Loa Loa (eye worm)	TK/Met protein kinase	0.0042	0.0047	0.0047
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0042	0.0047	0.0047
Trypanosoma cruzi	hypothetical protein	0.0046	0.0061	0.4325
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0046	0.0061	0.148
Entamoeba histolytica	tyrosin kinase, putative	0.0152	0.0401	0.2363
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.0918	0.5875
Schistosoma mansoni	hypothetical protein	0.025	0.0719	0.0705
Brugia malayi	Protein kinase domain containing protein	0.027	0.0782	0.0782
Schistosoma mansoni	axis inhibition protein axin	0.0506	0.1546	0.1533
Echinococcus granulosus	beta 1 syntrophin	0.0046	0.0061	0.0054
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Echinococcus multilocularis	protein kinase	0.0042	0.0047	0.0037
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0042	0.0047	0.0037
Echinococcus granulosus	protein tyrosine kinase	0.0042	0.0047	0.0037
Brugia malayi	PH domain containing protein	0.0046	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Leishmania major	hypothetical protein, conserved	0.0042	0.0047	0.334
Loa Loa (eye worm)	PH domain-containing protein	0.0046	0.0061	0.0061
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0038	0.0032	0.0032
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0506	0.1546	0.1833
Loa Loa (eye worm)	cytohesin 3	0.0046	0.0061	0.0061
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.2616	0.8364	0.8364
Entamoeba histolytica	hypothetical protein	0.0506	0.1546	1
Brugia malayi	ephrin receptor 1 precursor	0.0042	0.0047	0.0047
Echinococcus multilocularis	oxysterol binding protein 3	0.0046	0.0061	0.0054
Schistosoma mansoni	syntrophin	0.0046	0.0061	0.0045
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0059	0.0102	0.586
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0042	0.0047	0.0037
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Schistosoma mansoni	fibrocystin l	0.011	0.0265	0.0249
Echinococcus multilocularis	oxysterol binding protein 1	0.0046	0.0061	0.0054
Echinococcus granulosus	plexin a4	0.0695	0.2158	0.2566
Entamoeba histolytica	protein kinase, putative	0.0059	0.0102	0.0365
Echinococcus multilocularis	Pleckstrin y	0.0046	0.0061	0.0054
Brugia malayi	Dynamin	0.0046	0.0061	0.0061
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0059	0.0102	0.7243
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0042	0.0047	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0047	0.0037
Echinococcus multilocularis	tyrosine protein kinase shark	0.0042	0.0047	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0042	0.0047	0.0031
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Trichomonas vaginalis	conserved hypothetical protein	0.0506	0.1546	1
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0046	0.0061	0.148
Loa Loa (eye worm)	plexin A	0.0695	0.2158	0.2158
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0046	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Brugia malayi	Raf kinase	0.0042	0.0047	0.0047
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0059	0.0102	0.7243
Schistosoma mansoni	vav2	0.0046	0.0061	0.0045
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Echinococcus granulosus	semaphorin 5B	0.025	0.0719	0.0843
Schistosoma mansoni	plexin	0.0586	0.1804	0.1791
Entamoeba histolytica	hypothetical protein	0.0046	0.0061	0.0092
Trichomonas vaginalis	protein transport protein sec7, putative	0.0046	0.0061	0.024
Echinococcus multilocularis	Pleckstrin y	0.0046	0.0061	0.0054
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0047	0.0047
Echinococcus multilocularis	activated cdc42 kinase 1	0.0042	0.0047	0.0037
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0061	0.0092
Schistosoma mansoni	protein kinase	0.0042	0.0047	0.0031
Schistosoma mansoni	voltage-gated potassium channel	0.0041	0.0043	0.0027
Loa Loa (eye worm)	hypothetical protein	0.025	0.0719	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0047
Loa Loa (eye worm)	cytochrome P450 family protein	0.004	0.004	0.004
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.0572	0.3599
Trichomonas vaginalis	glucosylceramidase, putative	0.0216	0.0608	0.3833
Brugia malayi	hypothetical protein	0.0046	0.0061	0.0061
Echinococcus multilocularis	transcription factor collier	0.011	0.0265	0.0298
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Loa Loa (eye worm)	hypothetical protein	0.011	0.0265	0.0265
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0046	0.0061	0.0092
Schistosoma mansoni	zinc finger protein	0.0046	0.0061	0.0045
Schistosoma mansoni	protein kinase	0.0055	0.0088	0.0072
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0115	0.0282	0.0267
Trichomonas vaginalis	conserved hypothetical protein	0.0506	0.1546	1
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0042	0.0047	0.0031
Onchocerca volvulus		0.0042	0.0047	0.0185
Loa Loa (eye worm)	AUR protein kinase	0.0071	0.014	0.014
Echinococcus granulosus	regulator of G protein signaling 7	0.0506	0.1546	0.1833
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0042	0.0047	0.0149
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0506	0.1546	0.1533
Schistosoma mansoni	regulator of G protein signaling	0.0506	0.1546	0.1533
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0042	0.0047	0.0037
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.0265	0.1582
Plasmodium vivax	PH domain containing protein	0.0046	0.0061	0.148
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0016	0.0016
Brugia malayi	Sema domain containing protein	0.025	0.0719	0.0719
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Schistosoma mansoni	serine/threonine protein kinase	0.2393	0.7644	0.7641
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Onchocerca volvulus		0.0586	0.1804	1
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0312	0.0918	0.0918
Loa Loa (eye worm)	sema domain-containing protein	0.025	0.0719	0.0719
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0506	0.1546	0.1546
Loa Loa (eye worm)	hypothetical protein	0.012	0.0297	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Echinococcus multilocularis	actin binding protein anillin	0.0046	0.0061	0.0054
Loa Loa (eye worm)	hypothetical protein	0.02	0.0558	0.0558
Onchocerca volvulus		0.0042	0.0047	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0506	0.1546	0.1546
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Echinococcus granulosus	aurora kinase A	0.0071	0.014	0.0149
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Trypanosoma cruzi	NIMA-related kinase, putative	0.0059	0.0102	0.7243
Echinococcus multilocularis	exocyst complex component 2	0.011	0.0265	0.0298
Trypanosoma cruzi	hypothetical protein	0.0046	0.0061	0.4325
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0046	0.0061	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0506	0.1546	0.1546
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Echinococcus granulosus	Pleckstrin y	0.0046	0.0061	0.0054
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Echinococcus multilocularis	protein tyrosine kinase	0.0042	0.0047	0.0037
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.2616	0.8364	1
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0506	0.1546	1
Schistosoma mansoni	hypothetical protein	0.0046	0.0061	0.0045
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.011	0.0265	0.1582
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0042	0.0047	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Echinococcus multilocularis	Immunoglobulin	0.0115	0.0282	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase csk	0.0042	0.0047	0.0037
Entamoeba histolytica	protein kinase, putative	0.0059	0.0102	0.0365
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0047	0.0031
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0055	0.0088	0.0086
Onchocerca volvulus		0.0033	0.0016	0.0012
Brugia malayi	Protein kinase domain containing protein	0.0059	0.0102	0.0102
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Trichomonas vaginalis	glucosylceramidase, putative	0.0216	0.0608	0.3833
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0042	0.0047	0.0047
Schistosoma mansoni	hypothetical protein	0.0046	0.0061	0.0045
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0506	0.1546	0.1546
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0059	0.0102	0.7243
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0042	0.0047	0.0037
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0047	0.0047
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0061	0.4325
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.014	0.0763
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Brugia malayi	Oxysterol-binding protein	0.0046	0.0061	0.0061
Loa Loa (eye worm)	TK/INSR protein kinase	0.0042	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.012	0.0297	0.0297
Onchocerca volvulus		0.0042	0.0047	0.0185
Echinococcus multilocularis	tyrosine protein kinase csk	0.0042	0.0047	0.0037
Loa Loa (eye worm)	AUR protein kinase	0.0071	0.014	0.014
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Echinococcus multilocularis	regulator of G protein signaling	0.0506	0.1546	0.1833
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0042	0.0047	0.0047
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0047	0.0062	0.0055
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Trypanosoma cruzi	PH domain containing protein, putative	0.0046	0.0061	0.4325
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.2393	0.7644	0.7644
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Schistosoma mansoni	tyrosine protein kinase	0.0042	0.0047	0.0031
Trypanosoma cruzi	NIMA-related kinase, putative	0.0059	0.0102	0.7243
Entamoeba histolytica	PH domain containing protein	0.0046	0.0061	0.0092
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.014	0.0763
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0042	0.0047	0.0047
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0046	0.0061	0.0054
Echinococcus multilocularis	heat shock protein 70	0.0042	0.0047	0.0037
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0059	0.0102	0.7243
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.0572	0.3599
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0046	0.0061	0.0054
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0042	0.0047	0.0037
Onchocerca volvulus		0.0046	0.0061	0.0262
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.011	0.0265	0.1582
Echinococcus multilocularis	axis inhibition protein axin	0.0506	0.1546	0.1833
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Echinococcus multilocularis	myotubularin protein 13	0.0046	0.0061	0.0054
Echinococcus granulosus	Pleckstrin y	0.0046	0.0061	0.0054
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0042	0.0047	0.0037
Entamoeba histolytica	hypothetical protein	0.011	0.0265	0.1454
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0042	0.0047	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.0265	0.1582
Echinococcus multilocularis	integrin linked protein kinase	0.0042	0.0047	0.0037
Echinococcus granulosus	receptor type guanylyl cyclase	0.0042	0.0047	0.0037
Plasmodium falciparum	protein kinase, putative	0.0055	0.0088	0.438
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0042	0.0047	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0047
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0046	0.0061	0.0262
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Echinococcus multilocularis	cytohesin 1	0.0046	0.0061	0.0054
Brugia malayi	serine/threonine-protein kinase 6	0.0071	0.014	0.014
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0042	0.0047	0.0047
Schistosoma mansoni	serine/threonine-protein kinase	0.0059	0.0102	0.0086
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0042	0.0047	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Loa Loa (eye worm)	SRC-1	0.0042	0.0047	0.0047
Brugia malayi	hypothetical protein	0.025	0.0719	0.0719
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0042	0.0047	0.0031
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0042	0.0047	0.0037
Echinococcus granulosus	activated cdc42 kinase 1	0.0042	0.0047	0.0037
Trichomonas vaginalis	hypothetical protein	0.0046	0.0061	0.024
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Schistosoma mansoni	ephrin receptor	0.0047	0.0062	0.0046
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0042	0.0047	0.0037
Echinococcus granulosus	epidermal growth factor receptor	0.0042	0.0047	0.0037
Entamoeba histolytica	hypothetical protein	0.0046	0.0061	0.0092
Brugia malayi	SH2 domain containing protein	0.0042	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0282	0.0282
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0046	0.0061	0.0092
Trichomonas vaginalis	protein transport protein sec7, putative	0.0046	0.0061	0.024
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.0265	0.1582
Brugia malayi	Receptor family ligand binding region containing protein	0.0042	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0506	0.1546	0.1546
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Onchocerca volvulus		0.0042	0.0047	0.0185
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0042	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.025	0.0719	0.0719
Trypanosoma brucei	aurora B kinase	0.0071	0.014	1
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0042	0.0047	0.0149
Entamoeba histolytica	protein kinase domain containing protein	0.0152	0.0401	0.2363
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0042	0.0047	0.0037
Onchocerca volvulus	Tyrosine kinase homolog	0.0042	0.0047	0.0185
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0046	0.0061	0.0054
Echinococcus multilocularis	epidermal growth factor receptor	0.0042	0.0047	0.0037
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0046	0.0061	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0042	0.0047	0.0037
Echinococcus granulosus	twitchin	0.0128	0.0323	0.0368
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Schistosoma mansoni	z-protein (S1r protein)	0.0506	0.1546	0.1533
Onchocerca volvulus		0.025	0.0719	0.3942
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.0572	0.3599
Entamoeba histolytica	hypothetical protein	0.0059	0.0102	0.0365
Echinococcus multilocularis	insulin receptor	0.0042	0.0047	0.0037
Echinococcus granulosus	regulator of G protein signaling 7	0.0506	0.1546	0.1833
Onchocerca volvulus		0.0042	0.0047	0.0185
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0046	0.0061	0.0045
Toxoplasma gondii	protein kinase domain-containing protein	0.0059	0.0102	0.586
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0506	0.1546	0.1833
Echinococcus multilocularis	regulator of G protein signaling 7	0.0506	0.1546	0.1833
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0157	0.0419	0.0419
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0047
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Plasmodium vivax	hypothetical protein, conserved	0.0046	0.0061	0.148
Onchocerca volvulus		0.0046	0.0061	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0506	0.1546	0.1546
Brugia malayi	protein-tyrosine kinase	0.0042	0.0047	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0055	0.0088	0.0086
Schistosoma mansoni	dynamin	0.0046	0.0061	0.0045
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0312	0.0918	0.0918
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0038	0.0032	0.0032
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0059	0.0102	0.7243
Loa Loa (eye worm)	oxysterol binding protein	0.0046	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Onchocerca volvulus		0.0042	0.0047	0.0185
Schistosoma mansoni	hypothetical protein	0.0042	0.0047	0.0031
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0042	0.0047	0.0037
Leishmania major	hypothetical protein, conserved	0.0046	0.0061	0.4325
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0042	0.0047	0.0037
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Schistosoma mansoni	serine/threonine-protein kinase	0.0059	0.0102	0.0086
Entamoeba histolytica	hypothetical protein	0.011	0.0265	0.1454
Onchocerca volvulus	outspread protein homolog	0.0046	0.0061	0.0262
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0071	0.014	0.0149
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0047	0.0149
Giardia lamblia	Aurora kinase	0.0071	0.014	1
Toxoplasma gondii	hypothetical protein	0.0046	0.0061	0.148
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0059	0.0102	0.0509
Schistosoma mansoni	goodpasture antigen-binding protein	0.0046	0.0061	0.0045
Entamoeba histolytica	PH domain containing protein	0.0046	0.0061	0.0092
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0046	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Schistosoma mansoni	hypothetical protein	0.0046	0.0061	0.0045
Trichomonas vaginalis	centaurin gamma, putative	0.0046	0.0061	0.024
Leishmania major	protein kinase, putative	0.0059	0.0102	0.7243
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Trypanosoma cruzi	hypothetical protein	0.0046	0.0061	0.4325
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.0265	0.1582
Loa Loa (eye worm)	TK/ROR protein kinase	0.0042	0.0047	0.0047
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0042	0.0047	0.0037
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0047	0.0031
Echinococcus granulosus	ephrin type A receptor 4 A	0.0042	0.0047	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0336	0.0995	0.0995
Schistosoma mansoni	hypothetical protein	0.0046	0.0061	0.0045
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0506	0.1546	0.1533
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0115	0.0282	0.0319
Schistosoma mansoni	rho gtpase activating protein	0.0046	0.0061	0.0045
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0042	0.0047	0.0047
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0042	0.0047	0.0037
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0059	0.0102	0.586
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0042	0.0047	0.0037
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0038	0.0032	0.0019
Brugia malayi	regulator of G-protein signaling rgs-7	0.0506	0.1546	0.1546
Echinococcus granulosus	tyrosine protein kinase HCK	0.0042	0.0047	0.0037
Trichomonas vaginalis	STE family protein kinase	0.0042	0.0047	0.0149
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0047	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0047
Brugia malayi	PH domain containing protein	0.0046	0.0061	0.0061
Trichomonas vaginalis	kinesin light chain, putative	0.0046	0.0061	0.024
Schistosoma mansoni	voltage-gated potassium channel	0.0041	0.0043	0.0027
Schistosoma mansoni	regulator of G protein signaling	0.0506	0.1546	0.1533
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0055	0.0088	0.6257
Brugia malayi	Pleckstrin Homology Domain	0.0046	0.0061	0.0061
Echinococcus granulosus	Immunoglobulin	0.0115	0.0282	0.0319
Trichomonas vaginalis	CAMK family protein kinase	0.0042	0.0047	0.0149
Echinococcus granulosus	GRB2 associated binding protein 3	0.0046	0.0061	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0282	0.0282
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0059	0.0102	0.7243
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0042	0.0047	0.0047
Echinococcus multilocularis	axis inhibition protein axin	0.0506	0.1546	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0282	0.0282
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0042	0.0047	0.0037
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0042	0.0047	0.0149
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0047	0.0149
Brugia malayi	PH domain containing protein	0.0046	0.0061	0.0061
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0071	0.014	1
Onchocerca volvulus		0.0046	0.0061	0.0262
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0042	0.0047	0.0037
Entamoeba histolytica	hypothetical protein	0.0506	0.1546	1
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Loa Loa (eye worm)	serine/threonine protein kinase	0.0042	0.0047	0.0047
Trypanosoma cruzi	Protein kinase B	0.0059	0.0102	0.7243
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0042	0.0047	0.0037
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0059	0.0102	0.7243
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0016	0.0016
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0042	0.0047	0.0037
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0047	0.0031
Echinococcus multilocularis	c src tyrosine kinase	0.0042	0.0047	0.0037
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0059	0.0102	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Onchocerca volvulus		0.0042	0.0047	0.0185
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0055	0.0088	0.0086
Onchocerca volvulus		0.0046	0.0061	0.0262
Loa Loa (eye worm)	TK/DDR protein kinase	0.0042	0.0047	0.0047
Brugia malayi	Oxysterol binding protein	0.0046	0.0061	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0046	0.0061	0.0054
Echinococcus granulosus	Pleckstrin y	0.0046	0.0061	0.0054
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Echinococcus granulosus	beta-adrenergic receptor kinase	0.2393	0.7644	0.9138
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0042	0.0047	0.0037
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0042	0.0047	0.0037
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0061	0.0092
Schistosoma mansoni	nephrin	0.012	0.0297	0.0282
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0046	0.0061	0.0054
Schistosoma mansoni	oxysterol-binding protein 1	0.0046	0.0061	0.0045
Schistosoma mansoni	protein kinase	0.0042	0.0047	0.0031
Leishmania major	folate/biopterin transporter, putative	0.0059	0.0102	0.7243
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0042	0.0047	0.0047
Echinococcus multilocularis	Immunoglobulin	0.0115	0.0282	0.0319
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0042	0.0047	0.0037
Brugia malayi	integrin-linked kinase	0.0042	0.0047	0.0047
Schistosoma mansoni	serine/threonine RGC	0.0042	0.0047	0.0031
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0047	0.0031
Echinococcus granulosus	tyrosine protein kinase csk	0.0042	0.0047	0.0037
Brugia malayi	MAX-1A	0.0046	0.0061	0.0061
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Loa Loa (eye worm)	TK/FAK protein kinase	0.0042	0.0047	0.0047
Schistosoma mansoni	hypothetical protein	0.025	0.0719	0.0705
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0042	0.0047	0.0037
Entamoeba histolytica	protein kinase domain containing protein	0.0071	0.014	0.0623
Toxoplasma gondii	hypothetical protein	0.0046	0.0061	0.148
Loa Loa (eye worm)	AUR protein kinase	0.0071	0.014	0.014
Echinococcus granulosus	defective proboscis extension response	0.0115	0.0282	0.0319
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0047
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0047
Echinococcus granulosus	c src tyrosine kinase	0.0042	0.0047	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0586	0.1804	0.1804
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0047	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0016	0.0016
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Echinococcus granulosus	expressed protein	0.0506	0.1546	0.1833
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0061	0.0092
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0042	0.0047	0.0037
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0042	0.0047	0.0047
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0046	0.0061	0.0054
Leishmania major	protein kinase, putative	0.0055	0.0088	0.6257
Entamoeba histolytica	hypothetical protein	0.011	0.0265	0.1454
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0042	0.0047	0.0037
Echinococcus granulosus	transcription factor collier	0.011	0.0265	0.0298
Entamoeba histolytica	hypothetical protein	0.0059	0.0102	0.0365
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0061	0.0092
Echinococcus granulosus	raf serine:threonine protein kinase	0.0042	0.0047	0.0037
Trypanosoma brucei	protein kinase, putative	0.0055	0.0088	0.6257
Trichomonas vaginalis	centaurin alpha, putative	0.0046	0.0061	0.024
Echinococcus multilocularis	oxysterol binding protein 9	0.0046	0.0061	0.0054
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Echinococcus granulosus	tyrosine protein kinase csk	0.0042	0.0047	0.0037
Loa Loa (eye worm)	TK/ALK protein kinase	0.027	0.0782	0.0782
Onchocerca volvulus		0.0046	0.0061	0.0262
Entamoeba histolytica	protein kinase, putative	0.0059	0.0102	0.0365
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Onchocerca volvulus		0.0046	0.0061	0.0262
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0046	0.0061	0.0092
Echinococcus granulosus	calcium dependent secretion activator 1	0.0046	0.0061	0.0054
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0046	0.0061	0.148
Schistosoma mansoni	oxysterol-binding protein 1	0.0046	0.0061	0.0045
Brugia malayi	SH2 domain containing protein	0.0042	0.0047	0.0047
Schistosoma mansoni	semaphorin 5-related	0.025	0.0719	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0047
Loa Loa (eye worm)	uncoordinated protein 104	0.0046	0.0061	0.0061
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0061	0.0092
Echinococcus granulosus	axis inhibition protein axin	0.0506	0.1546	0.1833
Echinococcus granulosus	kinase suppressor of Ras 1	0.0042	0.0047	0.0037
Leishmania major	protein kinase, putative	0.0059	0.0102	0.7243
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0042	0.0047	0.0037
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0506	0.1546	1
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0071	0.014	1
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.2616	0.8364	1
Entamoeba histolytica	p21-activated kinase	0.0059	0.0102	0.0365
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0055	0.0088	0.6257
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0059	0.0102	0.7243
Schistosoma mansoni	protein kinase	0.0042	0.0047	0.0031
Brugia malayi	A-kinase anchor protein 10, precursor	0.0506	0.1546	0.1546
Echinococcus multilocularis	regulator of G protein signaling 3	0.0506	0.1546	0.1833
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0059	0.0102	0.7243
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Echinococcus granulosus	G protein coupled receptor kinase 1	0.1887	0.6009	0.7178
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Echinococcus granulosus	axis inhibition protein axin	0.0506	0.1546	0.1833
Trypanosoma cruzi	hypothetical protein	0.0046	0.0061	0.4325
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0115	0.0282	0.0267
Trypanosoma cruzi	hypothetical protein	0.0046	0.0061	0.4325
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Schistosoma mansoni	centaurin alpha	0.0046	0.0061	0.0045
Echinococcus multilocularis	beta 1 syntrophin	0.0046	0.0061	0.0054
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0046	0.0061	0.0054
Toxoplasma gondii	AtPH1 family protein	0.0046	0.0061	0.148
Schistosoma mansoni	goodpasture antigen-binding protein	0.0046	0.0061	0.0045
Entamoeba histolytica	protein kinase, putative	0.0071	0.014	0.0623
Echinococcus multilocularis	hypothetical protein	0.025	0.0719	0.0843
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0042	0.0047	0.0185
Echinococcus granulosus	cytohesin 1	0.0046	0.0061	0.0054
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0042	0.0047	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0047	0.0047
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0042	0.0047	0.0031
Brugia malayi	Cytochrome P450 family protein	0.004	0.004	0.004
Onchocerca volvulus		0.0042	0.0047	0.0185
Echinococcus granulosus	tyrosine protein kinase csk	0.0042	0.0047	0.0037
Echinococcus multilocularis	aurora kinase A	0.0071	0.014	0.0149
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0071	0.014	0.0623
Echinococcus granulosus	regulator of G protein signaling 3	0.0506	0.1546	0.1833
Echinococcus granulosus	protein kinase	0.0042	0.0047	0.0037
Plasmodium falciparum	oxysterol-binding protein, putative	0.0046	0.0061	0.148
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0059	0.0102	0.7243
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Loa Loa (eye worm)	hypothetical protein	0.011	0.0265	0.0265
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0042	0.0047	0.334
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0047
Entamoeba histolytica	hypothetical protein	0.0046	0.0061	0.0092
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0047	0.0149
Echinococcus granulosus	oxysterol binding protein 9	0.0046	0.0061	0.0054
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0046	0.0061	0.0054
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0059	0.0102	0.0365
Loa Loa (eye worm)	hypothetical protein	0.025	0.0719	0.0719
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0042	0.0047	0.0149
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0046	0.0061	0.0054
Schistosoma mansoni	serine/threonine protein kinase	0.2393	0.7644	0.7641
Entamoeba histolytica	PH domain containing protein	0.0046	0.0061	0.0092
Echinococcus granulosus	tyrosine kinase	0.0042	0.0047	0.0037
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0046	0.0061	0.148
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0061	0.0092
Brugia malayi	intermediate filament protein	0.0033	0.0016	0.0016
Brugia malayi	Sema domain containing protein	0.025	0.0719	0.0719
Echinococcus multilocularis	transfer RNA-Thr	0.0042	0.0047	0.0037
Schistosoma mansoni	protein tyrosine kinase	0.0042	0.0047	0.0031
Trypanosoma cruzi	hypothetical protein	0.0046	0.0061	0.4325
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Schistosoma mansoni	protein kinase	0.0055	0.0088	0.0072
Schistosoma mansoni	vesicular amine transporter	0.0117	0.029	0.0275
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0042	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Entamoeba histolytica	protein kinase , putative	0.0071	0.014	0.0623
Loa Loa (eye worm)	hypothetical protein	0.0506	0.1546	0.1546
Trichomonas vaginalis	conserved hypothetical protein	0.0506	0.1546	1
Onchocerca volvulus		0.0042	0.0047	0.0185
Trichomonas vaginalis	glucosylceramidase, putative	0.0205	0.0572	0.3599
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Brugia malayi	SRC-1	0.0042	0.0047	0.0047
Echinococcus granulosus	tyrosine kinase	0.0042	0.0047	0.0037
Onchocerca volvulus		0.0042	0.0047	0.0185
Echinococcus granulosus	tyrosine protein kinase Blk	0.0042	0.0047	0.0037
Trypanosoma cruzi	phosphatidylinositol-4-phosphate 5-kinase, putative	0.0046	0.0061	0.4325
Onchocerca volvulus		0.0042	0.0047	0.0185
Entamoeba histolytica	hypothetical protein	0.011	0.0265	0.1454
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0042	0.0047	0.0037
Loa Loa (eye worm)	PXA domain-containing protein	0.0506	0.1546	0.1546
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Brugia malayi	Uncoordinated protein 104	0.0046	0.0061	0.0061
Schistosoma mansoni	cell adhesion molecule	0.012	0.0297	0.0282
Onchocerca volvulus		0.0042	0.0047	0.0185
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0046	0.0061	0.0054
Entamoeba histolytica	protein kinase, putative	0.0059	0.0102	0.0365
Echinococcus granulosus	dynamin 1	0.0046	0.0061	0.0054
Schistosoma mansoni	hypothetical protein	0.0046	0.0061	0.0045
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0047	0.0047
Loa Loa (eye worm)	TK/RYK protein kinase	0.0042	0.0047	0.0047
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0046	0.0061	0.0054
Brugia malayi	TBC domain containing protein	0.0046	0.0061	0.0061
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0046	0.0061	0.0054
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0042	0.0047	0.0037
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Brugia malayi	Probable exocyst complex component Sec5	0.011	0.0265	0.0265
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Onchocerca volvulus		0.0042	0.0047	0.0185
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Echinococcus multilocularis	dynamin 1	0.0046	0.0061	0.0054
Brugia malayi	serine/threonine kinase 12	0.0071	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.025	0.0719	0.0719
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0046	0.0061	0.024
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0046	0.0061	0.0054
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0506	0.1546	0.1533
Echinococcus granulosus	exocyst complex component 2	0.011	0.0265	0.0298
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.014	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0282	0.0282
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0046	0.0061	0.0054
Loa Loa (eye worm)	RGS-3 protein	0.0506	0.1546	0.1546
Trypanosoma brucei	protein kinase, putative	0.0059	0.0102	0.7243
Onchocerca volvulus		0.0042	0.0047	0.0185
Trichomonas vaginalis	alpha chimerin, putative	0.0046	0.0061	0.024
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0038	0.0032	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Echinococcus multilocularis	FL cytokine receptor	0.0042	0.0047	0.0037
Leishmania major	protein kinase, putative	0.0071	0.014	1
Brugia malayi	PH domain containing protein	0.0046	0.0061	0.0061
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0046	0.0061	0.148
Loa Loa (eye worm)	hypothetical protein	0.011	0.0265	0.0265
Echinococcus granulosus	semaphorin 1A	0.025	0.0719	0.0843
Echinococcus granulosus	pleckstrin y domain containing family A	0.0046	0.0061	0.0054
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0042	0.0047	0.0037
Trichomonas vaginalis	protein kinase atn1, putative	0.0042	0.0047	0.0149
Leishmania major	hypothetical protein, conserved	0.0046	0.0061	0.4325
Brugia malayi	Plexin repeat family protein	0.0586	0.1804	0.1804
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0046	0.0061	0.148
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Loa Loa (eye worm)	rho-GTPase-activating	0.0046	0.0061	0.0061
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0046	0.0061	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.0265	0.1582
Schistosoma mansoni	protein kinase	0.0071	0.014	0.0125
Brugia malayi	Tyrosine-protein kinase PR2	0.0042	0.0047	0.0047
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0016	0.0016
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0016	0.0016
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0046	0.0061	0.148
Echinococcus granulosus	activated cdc42 kinase 1	0.0042	0.0047	0.0037
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0047	0.0037
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Trichomonas vaginalis	centaurin/arf, putative	0.0046	0.0061	0.024
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0047
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0071	0.014	0.0623
Echinococcus granulosus	integrin linked protein kinase	0.0042	0.0047	0.0037
Echinococcus multilocularis	tyrosine protein kinase csk	0.0042	0.0047	0.0037
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Schistosoma mansoni	regulator of G protein signaling	0.0506	0.1546	0.1533
Schistosoma mansoni	hypothetical protein	0.011	0.0265	0.0249
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0047	0.0047
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Brugia malayi	serine/threonine protein kinase 6	0.0071	0.014	0.014
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0061	0.024
Loa Loa (eye worm)	TK/CSK protein kinase	0.0042	0.0047	0.0047
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0157	0.0419	0.0419
Brugia malayi	Immunoglobulin I-set domain containing protein	0.012	0.0297	0.0297
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0046	0.0061	0.0054
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0059	0.0102	0.0509
Brugia malayi	hypothetical protein	0.012	0.0297	0.0297
Trypanosoma cruzi	ADP-ribosylation factor family, putative	0.0046	0.0061	0.4325
Brugia malayi	hypothetical protein	0.0042	0.0047	0.0047
Brugia malayi	hypothetical protein	0.0042	0.0047	0.0047
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0042	0.0047	0.0037
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0071	0.014	0.0149
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Loa Loa (eye worm)	hypothetical protein	0.025	0.0719	0.0719
Brugia malayi	PH domain containing protein	0.0046	0.0061	0.0061
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0059	0.0102	0.0102
Echinococcus granulosus	roundabout 2	0.012	0.0297	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0047	0.0047
Entamoeba histolytica	protein kinase, putative	0.0071	0.014	0.0623
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0046	0.0061	0.0262
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0047	0.0047
Schistosoma mansoni	protein kinase	0.0042	0.0047	0.0031
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Trichomonas vaginalis	AGC family protein kinase	0.0059	0.0102	0.0509
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031
Echinococcus multilocularis	semaphorin 5B	0.025	0.0719	0.0843
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0047	0.0047
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0042	0.0047	0.0047
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0046	0.0061	0.0061
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0046	0.0061	0.0045
Entamoeba histolytica	hypothetical protein	0.0046	0.0061	0.0092
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0055	0.0088	0.6257
Echinococcus multilocularis	roundabout 2	0.012	0.0297	0.0337
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0047	0.0047
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0047	0.0047
Plasmodium falciparum	PH domain-containing protein, putative	0.0046	0.0061	0.148
Brugia malayi	hypothetical protein	0.0506	0.1546	0.1546
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0047	0.0149
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0042	0.0047	0.0037
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0046	0.0061	0.0092
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0046	0.0061	0.0092
Echinococcus granulosus	tyrosine protein kinase	0.0042	0.0047	0.0037
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.0918	0.5875
Schistosoma mansoni	myotubularin-related protein	0.0046	0.0061	0.0045
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0047	0.0037
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0059	0.0102	0.7243
Schistosoma mansoni	tyrosine kinase	0.0042	0.0047	0.0031

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 1 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 2.511886432 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 3.16227766 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 12.58925412 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
Potency (ADMET)	= 2.5119 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ]	ChEMBL.	No reference
Potency (ADMET)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ]	ChEMBL.	No reference
Potency (ADMET)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ]	ChEMBL.	No reference
Potency (ADMET)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (ADP-Glo Assay). (Class of assay: confirmatory) [Related pubchem assays: 1379 ]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (Kinase-Glo Assay). (Class of assay: confirmatory) [Related pubchem assays: 1379 ]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1516028

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1401456