Detailed information for compound 1460265

Basic information

Technical information
  • TDR Targets ID: 1460265
  • Name: EU-0086146
  • MW: 368.383 | Formula: C20H20N2O5
  • H donors: 1 H acceptors: 4 LogP: 1.1 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1ccc(c(c1)N1C(=O)C2C(C1=O)C1CC2C=C1)N1CCOCC1
  • InChi: 1S/C20H20N2O5/c23-18-16-11-1-2-12(9-11)17(16)19(24)22(18)15-10-13(20(25)26)3-4-14(15)21-5-7-27-8-6-21/h1-4,10-12,16-17H,5-9H2,(H,25,26)
  • InChiKey: CCWCSIOWVTWCQZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • A2573/0109733
  • 3-(3,5-dioxo-4-azatricyclo[5.2.1.0~2,6~]dec-8-en-4-yl)-4-(4-morpholinyl)benzoic acid
  • MLS000676683
  • SMR000298324
  • Oprea1_095116

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0049 0.0111 0.0107
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0546 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0065 0.009
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0041 0.0048
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0026 0.0036
Brugia malayi hypothetical protein 0.0232 0.0564 0.056
Echinococcus multilocularis serotonin receptor 0.0021 0.0041 0.0048
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0015 0.0135
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0022
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.003 0.0042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.0041 0.0057
Onchocerca volvulus 0.0035 0.0076 0.0086
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0256 0.8933
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0041 0.0057
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.0041 0.0048
Trypanosoma cruzi C-14 sterol reductase, putative 0.0095 0.0223 0.022
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.003 0.0398
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0021 0.0018
Brugia malayi hypothetical protein 0.0021 0.0041 0.0037
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0015 0.0135
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.0041 0.0048
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0076 0.2497
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0035 0.3029
Leishmania major cytochrome p450-like protein 0.0007 0.0007 0.0003
Brugia malayi vesicular acetylcholine transporter unc-17 0.2912 0.7195 0.7194
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.0041 0.0037
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0015 0.0011
Brugia malayi neuropeptide F receptor 0.0021 0.0041 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.001 0.068
Loa Loa (eye worm) serotonin transporter b 0.0088 0.0206 0.0202
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0041 0.0048
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0041 0.0048
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.0041 0.0048
Loa Loa (eye worm) solute carrier family 6 member 4 0.0088 0.0206 0.0202
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0015 0.0135
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0009 0.0028
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.0041 0.0037
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Schistosoma mansoni sodium-dependent amino acid transporter 0.0015 0.0026 0.0036
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.001 0.0005
Plasmodium falciparum amino acid transporter, putative 0.0015 0.0026 0.2172
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0007 0.0007 0.0405
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0021 0.0041 0.0057
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.0041 0.0048
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0013 0.0009
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0015 0.0135
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0004 0.0236
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0035 0.0039
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.003 0.2536
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0015 0.0135
Schistosoma mansoni histamine h1 receptor 0.0021 0.0041 0.0057
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0015 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Leishmania major DNA polymerase eta, putative 0.0019 0.0036 0.0032
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0041 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0009 0.0028
Echinococcus multilocularis allatostatin A receptor 0.0021 0.0041 0.0048
Schistosoma mansoni cpg binding protein 0.0037 0.008 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0015 0.0135
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Schistosoma mansoni cpg binding protein 0.0035 0.0075 0.0104
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0015 0.0026 0.0027
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0007 0.0007 0.0405
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0015 0.0026 0.0027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0036 0.0545
Brugia malayi G-protein coupled receptor 0.0021 0.0041 0.0037
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0017 0.0174
Onchocerca volvulus 0.0021 0.0041 0.0037
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0015 0.0011
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.001 0.0007
Leishmania major cytochrome p450-like protein 0.0007 0.0007 0.0003
Plasmodium vivax glutathione reductase, putative 0.0047 0.0106 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0026 0.0027
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0041 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0073
Brugia malayi Pre-SET motif family protein 0.0031 0.0065 0.0061
Onchocerca volvulus 0.0021 0.0041 0.0037
Toxoplasma gondii hypothetical protein 0.0015 0.0026 0.1676
Echinococcus granulosus geminin 0.0502 0.123 0.1702
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0015 0.0135
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0026 0.0022
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0286 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0015 0.0011
Onchocerca volvulus 0.0021 0.0041 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0035 0.3044
Brugia malayi Cytochrome P450 family protein 0.0007 0.0007 0.0003
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0041 0.0037
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.003 0.1918
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0015 0.0026 0.7515
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0007 0.0007 0.0405
Trichomonas vaginalis ABC transporter, putative 0.001 0.0015 0.0135
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0075 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0041 0.0057
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0015 0.0026 0.0027
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0041 0.0048
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0076 0.0073
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0015 0.0011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0035 0.0039
Onchocerca volvulus 0.0035 0.0075 0.0084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0041 0.0057
Trypanosoma brucei unspecified product 0.0013 0.0021 0.0018
Schistosoma mansoni amine GPCR 0.0021 0.0041 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Schistosoma mansoni ap endonuclease 0.0018 0.0035 0.0048
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0026 0.0027
Onchocerca volvulus 0.0021 0.0041 0.0037
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0015 0.0135
Echinococcus granulosus serotonin receptor 0.0021 0.0041 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0073
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0015 0.0026 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.003 0.8023
Toxoplasma gondii exonuclease III APE 0.0018 0.0035 0.2254
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.0041 0.0048
Echinococcus granulosus somatostatin receptor 0.0021 0.0041 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Brugia malayi Thioredoxin reductase 0.0047 0.0106 0.0102
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Schistosoma mansoni hypothetical protein 0.0021 0.0041 0.0057
Schistosoma mansoni opsin-like receptor 0.0021 0.0041 0.0057
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0027
Plasmodium vivax amine transporter, putative 0.0015 0.0026 0.2172
Brugia malayi GnHR receptor homolog 0.0021 0.0041 0.0037
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0015 0.0011
Echinococcus multilocularis somatostatin receptor 0.0021 0.0041 0.0048
Plasmodium vivax SET domain protein, putative 0.0031 0.0065 0.5972
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.0041 0.0048
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0036 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0021 0.0018
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0007 0.0007 0.0405
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.0041 0.0048
Schistosoma mansoni hypothetical protein 0.0021 0.0041 0.0057
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.001 0.0005
Brugia malayi hypothetical protein 0.0021 0.0041 0.0037
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0017 0.0013
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0041 0.0048
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.0041 0.0057
Onchocerca volvulus 0.0021 0.0041 0.0037
Schistosoma mansoni opsin-like receptor 0.0021 0.0041 0.0057
Echinococcus granulosus bloom syndrome protein 0.0021 0.0041 0.0048
Echinococcus granulosus serotonin transporter 0.0088 0.0206 0.0277
Loa Loa (eye worm) CYP4Cod1 0.0007 0.0007 0.0003
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0004 0.0236
Onchocerca volvulus 0.0031 0.0065 0.007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.001 0.0015 0.0011
Echinococcus multilocularis geminin 0.0502 0.123 0.1702
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0015 0.0011
Schistosoma mansoni cytochrome P450 0.0007 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0065 0.0061
Onchocerca volvulus 0.0015 0.0026 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0065 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.003 0.0026
Leishmania major sterol C-24 reductase, putative 0.0049 0.0111 0.0107
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0076 0.0097
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Loa Loa (eye worm) beta-lactamase 0.0035 0.0076 0.0073
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0026 0.2172
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0577 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0106 0.0148
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0024 0.1538
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0035 0.0295
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0007 0.0003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.003 0.3575
Schistosoma mansoni amine GPCR 0.0021 0.0041 0.0057
Plasmodium falciparum multidrug resistance protein 1 0.001 0.0015 0.1072
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0041 0.0048
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0026
Toxoplasma gondii hypothetical protein 0.0015 0.0026 0.1676
Brugia malayi beta-lactamase family protein 0.0035 0.0076 0.0073
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0007 0.0007 0.0405
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0076 0.1292
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0021 0.0041 0.0037
Echinococcus multilocularis dna polymerase eta 0.0019 0.0036 0.0041
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0015 0.0135
Brugia malayi hypothetical protein 0.0021 0.0041 0.0037
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0013 0.0009
Giardia lamblia DINP protein human, muc B family 0.0019 0.0036 1
Schistosoma mansoni Lamin B receptor (ERG24) 0.0095 0.0223 0.031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0022
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0041 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0021 0.0018
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.0007 0.0003
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0007 0.0007 0.0003
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0015 0.0026 0.0036
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0076 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0009 0.0028
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.003 0.0026
Echinococcus multilocularis lamin b receptor 0.0095 0.0223 0.0301
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0041 0.0048
Trypanosoma brucei C-8 sterol isomerase, putative 0.4046 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Echinococcus granulosus cpg binding protein 0.0037 0.008 0.0102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0009 0.0028
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0041 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0015 0.0135
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Brugia malayi Dopamine receptor 0.0021 0.0041 0.0037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0004 0.0006
Trypanosoma brucei unspecified product 0.0019 0.0036 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0041 0.0057
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.0041 0.0057
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0026 0.1676
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0036 0.0041
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0007 0.0007 0.0405
Schistosoma mansoni neuropeptide receptor 0.0021 0.0041 0.0057
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0065 0.0081
Echinococcus granulosus lamin b receptor 0.0095 0.0223 0.0301
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0015 0.0011
Leishmania major C-14 sterol reductase, putative 0.0095 0.0223 0.022
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0026 0.0027
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0073
Loa Loa (eye worm) norepinephrine transporter 0.0088 0.0206 0.0202
Entamoeba histolytica P-glyco protein 6, putative 0.001 0.0015 0.406
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0041 0.0057
Onchocerca volvulus 0.0021 0.0041 0.0037
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.0041 0.0048
Schistosoma mansoni opsin-like receptor 0.0021 0.0041 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0036 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0076 0.1217
Plasmodium falciparum transporter, putative 0.0015 0.0026 0.2172
Brugia malayi beta-lactamase family protein 0.0035 0.0076 0.0073
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.0041 0.0057
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0035 0.0031
Echinococcus granulosus fmrfamide receptor 0.0021 0.0041 0.0048
Onchocerca volvulus 0.0047 0.0106 0.0128
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0015 0.0026 0.0027
Echinococcus multilocularis sex peptide receptor 0.0021 0.0041 0.0048
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0007 0.0007 0.0405
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0026 0.0036
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0007 0.0007 0.0405
Onchocerca volvulus 0.0021 0.0041 0.0037
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0036 0.0032
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.003 0.3575
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0036 0.0032
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0007 0.0007 0.0405
Onchocerca volvulus 0.0021 0.0041 0.0037
Plasmodium falciparum glutathione reductase 0.0016 0.003 0.2536
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0007 0.0007 0.0405
Brugia malayi multidrug resistance protein 3 0.001 0.0015 0.0011
Loa Loa (eye worm) RecQ helicase 0.0021 0.0041 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.0041 0.0048
Schistosoma mansoni multidrug resistance protein 0.001 0.0015 0.002
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.001 0.2118
Trichomonas vaginalis esterase, putative 0.0035 0.0076 0.1217
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.0041 0.0048
Mycobacterium tuberculosis Probable reductase 0.0108 0.0256 0.462
Toxoplasma gondii thioredoxin reductase 0.0047 0.0106 0.6867
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.003 0.0026
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0021 0.0041 0.0037
Mycobacterium tuberculosis Conserved protein 0.0035 0.0076 0.1292
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.0041 0.0048
Onchocerca volvulus 0.0021 0.0041 0.0037
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0041 0.0048
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0026 0.0036
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.0041 0.0057
Entamoeba histolytica P-glycoprotein-1 0.001 0.0015 0.406
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.2912 0.7195 1
Entamoeba histolytica P-glycoprotein-2, putative 0.001 0.0015 0.406
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Onchocerca volvulus Neuropeptide F receptor homolog 0.0021 0.0041 0.0037
Echinococcus granulosus neuropeptide s receptor 0.0021 0.0041 0.0048
Echinococcus granulosus dna polymerase kappa 0.0019 0.0036 0.0041
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.003 0.0026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0174 0.0242
Brugia malayi Cytochrome P450 family protein 0.0007 0.0007 0.0003
Brugia malayi RE15519p 0.0021 0.0041 0.0037
Entamoeba histolytica P-glycoprotein-2 0.001 0.0015 0.406
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Schistosoma mansoni biogenic amine receptor 0.0021 0.0041 0.0057
Brugia malayi sulfakinin receptor protein 0.0021 0.0041 0.0037
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.0564 0.0775
Onchocerca volvulus 0.0035 0.0076 0.0086
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.003 0.0026
Echinococcus granulosus neuropeptide receptor 0.0021 0.0041 0.0048
Schistosoma mansoni hypothetical protein 0.0502 0.123 0.171
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0076 0.1217
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Onchocerca volvulus 0.0021 0.0041 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0011
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.001 0.068
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0026 0.0036
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0017 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Brugia malayi Cytochrome P450 family protein 0.0007 0.0007 0.0003
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.0015 0.0135
Trichomonas vaginalis abcb9, putative 0.001 0.0015 0.0135
Loa Loa (eye worm) hypothetical protein 0.0088 0.0206 0.0202
Onchocerca volvulus 0.0015 0.0026 0.0016
Schistosoma mansoni amine GPCR 0.0021 0.0041 0.0057
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0004 0.0236
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0247 0.06 0.0597
Toxoplasma gondii cytochrome p450 superfamily protein 0.0007 0.0007 0.0427
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0026
Leishmania major hypothetical protein, conserved 0.0035 0.0076 0.0073
Brugia malayi G protein-coupled receptor 0.0021 0.0041 0.0037
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0036 0.4455
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0041 0.0598
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0041 0.0057
Brugia malayi glutathione reductase 0.0047 0.0106 0.0102
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0076 0.0073
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0041 0.0057
Echinococcus granulosus dna polymerase eta 0.0019 0.0036 0.0041
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0076 0.0073
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0036 0.0041
Trypanosoma brucei trypanothione reductase 0.0047 0.0106 0.0102
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0065 0.0081
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0013 0.0018
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0041 0.0048
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.0007 0.0003
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0019 0.0015
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.0041 0.0057
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.0041 0.0048
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0018 0.0015
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0036 0.005
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0015 0.0026 0.0022
Plasmodium falciparum glutathione reductase 0.0047 0.0106 1
Brugia malayi hypothetical protein 0.0021 0.0041 0.0037
Brugia malayi Serotonin receptor 0.0021 0.0041 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Onchocerca volvulus 0.0021 0.0041 0.0037
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0007 0.0007 0.0405
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0041 0.0057
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0035 0.4291
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Brugia malayi hypothetical protein 0.0021 0.0041 0.0037
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.0041 0.0048
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0065 0.4196
Trichomonas vaginalis taga, putative 0.001 0.0015 0.0135
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0106 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0015 0.0011
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.003 0.2536
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.0041 0.0037
Brugia malayi hypothetical protein 0.0021 0.0041 0.0037
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.0564 0.0775
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Schistosoma mansoni amine GPCR 0.0021 0.0041 0.0057
Trichomonas vaginalis abcb9, putative 0.001 0.0015 0.0135
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0015 0.0135
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0015 0.0011
Trypanosoma brucei C-14 sterol reductase, putative 0.0095 0.0223 0.022
Loa Loa (eye worm) hypothetical protein 0.0232 0.0564 0.056
Brugia malayi neuropeptide F receptor 0.0021 0.0041 0.0037
Brugia malayi hypothetical protein 0.0021 0.0041 0.0037
Loa Loa (eye worm) hypothetical protein 0.0088 0.0206 0.0202
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0036 0.0511
Trypanosoma cruzi C-8 sterol isomerase, putative 0.4046 1 1
Echinococcus granulosus orexin receptor type 2 0.0021 0.0041 0.0048
Echinococcus granulosus hypothetical protein 0.0021 0.0041 0.0048
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0106 0.0102
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.001 0.0007
Leishmania major cytochrome p450-like protein 0.0007 0.0007 0.0003
Entamoeba histolytica P-glycoprotein-2 0.001 0.0015 0.406
Onchocerca volvulus 0.0237 0.0577 0.0783
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0026
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0041 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0036 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.001 0.0015 0.0947
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0009 0.0028
Mycobacterium ulcerans beta-lactamase 0.0035 0.0076 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0088 0.0206 0.0202
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0026 0.0022
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0256 0.462
Brugia malayi hypothetical protein 0.0021 0.0041 0.0037
Loa Loa (eye worm) hypothetical protein 0.2068 0.5106 0.5104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0026
Brugia malayi ORL1-like opioid receptor 0.0021 0.0041 0.0037
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.003 0.2536
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.0041 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0041 0.0048
Loa Loa (eye worm) cytochrome P450 0.0007 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Onchocerca volvulus 0.0021 0.0041 0.0037
Brugia malayi putative neuropeptide receptor 0.0021 0.0041 0.0037
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0286 0.5172
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0035 0.9668
Schistosoma mansoni vesicular acetylcholine transporter 0.2912 0.7195 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.0041 0.0048
Brugia malayi G-protein coupled receptor 0.0021 0.0041 0.0037
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0041 0.0057
Echinococcus multilocularis vesicular acetylcholine transporter 0.2912 0.7195 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.003 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.003 0.0041
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0026 0.0022
Echinococcus granulosus g protein coupled receptor 0.0021 0.0041 0.0048
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0041 0.0048
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.001 0.0005
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.0041 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0076 0.0073
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0026 0.0027
Schistosoma mansoni neuropeptide receptor 0.0021 0.0041 0.0057
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0041 0.0048
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.0041 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0015 0.0135
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.0041 0.0048
Loa Loa (eye worm) hypothetical protein 0.4046 1 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0015 0.0026 0.0027
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0106 0.0102
Brugia malayi cytochrome P450 0.0007 0.0007 0.0003
Trichomonas vaginalis ABC transporter, putative 0.001 0.0015 0.0135
Onchocerca volvulus 0.0021 0.0041 0.0037
Brugia malayi Melatonin receptor type 1A 0.0021 0.0041 0.0037
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0041 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0009 0.0028
Schistosoma mansoni multidrug resistance protein 0.001 0.0015 0.002
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0015 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0009 0.0028
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0036 0.0032
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0026 0.0036
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0015 0.0135
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.0041 0.0037
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Echinococcus granulosus sex peptide receptor 0.0021 0.0041 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Plasmodium falciparum thioredoxin reductase 0.0047 0.0106 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0026 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0009 0.0028
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Brugia malayi CXXC zinc finger family protein 0.0035 0.0075 0.0071
Brugia malayi Dopamine receptor protein 2 0.0021 0.0041 0.0037
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0007 0.0007 0.0405
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0017 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0036 0.0545
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0018 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0041 0.0057
Schistosoma mansoni hypothetical protein 0.0021 0.0041 0.0057
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.0041 0.0037
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0015 0.0135
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Leishmania major DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0009 0.0028
Schistosoma mansoni amine GPCR 0.0021 0.0041 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0065 0.009
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0041 0.0048
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.0041 0.0048
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0009 0.0028
Schistosoma mansoni neuropeptide receptor 0.0021 0.0041 0.0057
Toxoplasma gondii ABC1 family protein 0.0035 0.0076 0.494
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0035 0.049
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0041 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0076 0.1217
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0036 0.0032
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0076 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0007 0.0007 0.0405
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.001 0.0015 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0009 0.0028
Brugia malayi Dopamine receptor protein 1 0.0021 0.0041 0.0037
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0015 0.0026 0.0036
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0007 0.0007 0.0405
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0036 0.0032
Onchocerca volvulus 0.0015 0.0026 0.0016
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0106 0.1843
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.0041 0.0037
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0256 0.462
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0036 0.005
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0004 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.003 0.0026
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.2912 0.7195 0.7194
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0041 0.0057
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.003 0.0398
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0041 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0073
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.003 0.1918
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0088 0.0206 0.0202
Plasmodium falciparum thioredoxin reductase 0.0016 0.003 0.2536
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0035 0.0031
Trypanosoma brucei unspecified product 0.0013 0.0021 0.0018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0506 0.0502
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.0041 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0009 0.0028
Loa Loa (eye worm) multidrug resistance protein 3 0.001 0.0015 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0076 0.1217
Echinococcus granulosus vesicular acetylcholine transporter 0.2912 0.7195 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0041 0.0598
Leishmania major trypanothione reductase 0.0047 0.0106 0.0102
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.0041 0.0048
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.0041 0.0048
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0015 0.0135
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Brugia malayi Cytochrome P450 family protein 0.0007 0.0007 0.0003
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0041 0.0048
Echinococcus granulosus allatostatin A receptor 0.0021 0.0041 0.0048
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0256 0.462
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0007 0.0003
Schistosoma mansoni smdr2 0.001 0.0015 0.002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0065 0.0081
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0018 0.0016
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.0041 0.0048
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0015 0.0135
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0011
Trypanosoma cruzi sterol C-24 reductase, putative 0.0049 0.0111 0.0107
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.0041 0.0048
Onchocerca volvulus 0.0088 0.0206 0.0266
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0041 0.0057
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0256 0.462
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.0041 0.0057
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0015 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0076 0.1217
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0007 0.0003
Schistosoma mansoni DNA helicase recq5 0.0009 0.001 0.0015
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0015 0.0135
Trichomonas vaginalis ABC transporter, putative 0.001 0.0015 0.0135
Mycobacterium ulcerans lipase LipD 0.0035 0.0076 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1085 0.2672 0.3709
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0013 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0036 0.0032
Schistosoma mansoni hypothetical protein 0.0007 0.0007 0.0009
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.001 0.0669
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0035 0.049
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0026 0.1676
Brugia malayi follicle stimulating hormone receptor 0.0247 0.06 0.0597
Schistosoma mansoni hypothetical protein 0.0502 0.123 0.171
Schistosoma mansoni ap endonuclease 0.0018 0.0035 0.0048
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0076 0.1292
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0076 0.0106
Echinococcus granulosus g protein coupled receptor 0.0021 0.0041 0.0048
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0007 0.0007 0.0003
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0007 0.0007 0.0405
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.0041 0.0057
Schistosoma mansoni myosin xvIII 0.0021 0.0041 0.0057
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.001 0.0015 0.0011
Schistosoma mansoni DNA helicase recq1 0.0009 0.001 0.0015
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.0041 0.0048
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.003 0.0032
Treponema pallidum sodium- and chloride- dependent transporter 0.0088 0.0206 1
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.0041 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.001 0.0007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0041 0.0048
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0041 0.0048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0065 0.009
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0035 0.0031
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.0041 0.0057
Trichomonas vaginalis helicase, putative 0.0008 0.0009 0.0028
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0035 0.0031
Echinococcus multilocularis cpg binding protein 0.0037 0.008 0.0102
Schistosoma mansoni multidrug resistance protein 0.001 0.0015 0.002
Echinococcus multilocularis serotonin transporter 0.0088 0.0206 0.0277
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Schistosoma mansoni DNA polymerase eta 0.0019 0.0036 0.005
Onchocerca volvulus 0.0021 0.0041 0.0037
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0026 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Schistosoma mansoni hypothetical protein 0.0021 0.0041 0.0057
Echinococcus multilocularis orexin receptor type 2 0.0021 0.0041 0.0048
Onchocerca volvulus 0.0021 0.0041 0.0037
Schistosoma mansoni sodium/chloride dependent transporter 0.0088 0.0206 0.0286
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0073
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0041 0.0048
Mycobacterium tuberculosis Conserved protein 0.0035 0.0076 0.1292
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0088 0.0206 0.0286
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0286 0.5172
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0026
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0041 0.0048
Echinococcus multilocularis serotonin receptor 0.0021 0.0041 0.0048
Brugia malayi hypothetical protein 0.0021 0.0041 0.0037
Onchocerca volvulus 0.0021 0.0041 0.0037
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0026 0.0027
Brugia malayi Pre-SET motif family protein 0.0209 0.0506 0.0502
Trypanosoma brucei cytochrome P450, putative 0.0007 0.0007 0.0003
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0015 0.0011
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0041 0.0037
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0007 0.0007 0.0405
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0007 0.0007 0.0405
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0022
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0035 0.0031
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0007 0.0003
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0035 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.003 0.0026
Schistosoma mansoni cpg binding protein 0.0037 0.008 0.0111
Trichomonas vaginalis ABC transporter, putative 0.001 0.0015 0.0135
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0007 0.0007 0.0405
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0041 0.0057
Echinococcus granulosus tm gpcr rhodopsin 0.1085 0.2672 0.3709
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0019 0.0015
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0256 0.462
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0076 0.0106
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0026
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0041 0.0048
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0035 0.963
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0106 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0041 0.0057
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0041 0.0037
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0035 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.0041 0.0048
Brugia malayi hypothetical protein 0.0015 0.0026 0.0022
Echinococcus granulosus g-protein coupled receptor 0.0021 0.0041 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0036 0.0041
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0076 0.1292
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0009 0.0028
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0017 0.4666
Echinococcus granulosus neuropeptide receptor 0.0021 0.0041 0.0048
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0154 1
Brugia malayi hypothetical protein 0.0021 0.0041 0.0037
Plasmodium vivax multidrug resistance protein 1, putative 0.001 0.0015 0.1072
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0076 0.7094
Brugia malayi ABC transporter family protein 0.001 0.0015 0.0011
Onchocerca volvulus 0.0035 0.0076 0.0086
Schistosoma mansoni adenoreceptor 0.0021 0.0041 0.0057
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.0041 0.0048
Brugia malayi beta-lactamase 0.0035 0.0076 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0041 0.0057
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.0041 0.0037
Schistosoma mansoni hypothetical protein 0.0047 0.0106 0.0148
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0076 0.1292
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.0015 0.0947
Echinococcus granulosus g protein coupled receptor 0.0021 0.0041 0.0048
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0026 0.0022
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0015 0.0026 0.1676
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0007 0.0007 0.0405
Loa Loa (eye worm) glutathione reductase 0.0047 0.0106 0.0102
Loa Loa (eye worm) hypothetical protein 0.0015 0.0026 0.0022
Onchocerca volvulus 0.0021 0.0041 0.0037
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0036 0.0511
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.003 0.2536
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0015 0.0011
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0015 0.0011
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0041 0.0048
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0106 0.0138
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0007 0.0007 0.0003
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0007 0.0007 0.0405
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.0015 0.0135
Brugia malayi AKH receptor 0.0021 0.0041 0.0037
Mycobacterium leprae Probable lipase LipE 0.0035 0.0076 0.2497
Mycobacterium tuberculosis Conserved protein 0.0035 0.0076 0.1292
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0041 0.0048
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.003 0.0026
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0018 0.0016
Trypanosoma cruzi C-14 sterol reductase, putative 0.0095 0.0223 0.022
Schistosoma mansoni biogenic amine receptor 0.0021 0.0041 0.0057
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.006 0.0075
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0286 0.5172
Mycobacterium ulcerans hypothetical protein 0.0035 0.0076 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0007 0.0003
Trypanosoma cruzi sterol C-24 reductase, putative 0.0049 0.0111 0.0107
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0036 0.4455
Entamoeba histolytica P-glycoprotein-5 0.001 0.0015 0.406
Brugia malayi larval opioid receptor 0.0021 0.0041 0.0037
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0076 0.1292
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.0041 0.0037
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0076 0.1292
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0026 0.0036
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0007 0.0007 0.0405
Schistosoma mansoni biogenic amine receptor 0.0021 0.0041 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0041 0.0057
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.003 0.0032
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0035 0.3044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0041 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0076 0.0073
Leishmania major p-glycoprotein 0.001 0.0015 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.0041 0.0037
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0041 0.0048
Leishmania major C-8 sterol isomerase-like protein 0.4046 1 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0035 0.0523
Schistosoma mansoni neuropeptide receptor 0.0021 0.0041 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.003 0.0427
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0015 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.0041 0.0037
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0024 0.2004
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0041 0.0048
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0076 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.003 0.0026
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0106 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0036 0.0032
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0026 0.0022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0041 0.0057
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0076 0.1292
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0036 0.0032
Brugia malayi Serotonin receptor 0.0021 0.0041 0.0037
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.0041 0.0048
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.001 0.0014 0.0011
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.0041 0.0048
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.003 0.3575
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0009 0.0028
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0015 0.0135
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0036 0.0032
Trichomonas vaginalis abcb9, putative 0.001 0.0015 0.0135
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.0041 0.0057
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0037
Entamoeba histolytica P-glycoprotein 5, putative 0.001 0.0015 0.406

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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