Detailed information for compound 1533181

Basic information

Technical information
  • TDR Targets ID: 1533181
  • Name: 1-[(2S)-2-amino-4-methylsulfanylbutanoyl]-N-[ (2S)-1-[(4-methoxyphenyl)methylamino]-1-oxopr opan-2-yl]piperidine-4-carboxamide
  • MW: 450.595 | Formula: C22H34N4O4S
  • H donors: 3 H acceptors: 3 LogP: 0.84 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCC[C@@H](C(=O)N1CCC(CC1)C(=O)N[C@H](C(=O)NCc1ccc(cc1)OC)C)N
  • InChi: 1S/C22H34N4O4S/c1-15(20(27)24-14-16-4-6-18(30-2)7-5-16)25-21(28)17-8-11-26(12-9-17)22(29)19(23)10-13-31-3/h4-7,15,17,19H,8-14,23H2,1-3H3,(H,24,27)(H,25,28)/t15-,19-/m0/s1
  • InChiKey: PDZYFGNOSMRVJC-KXBFYZLASA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2S)-2-amino-4-methylsulfanyl-butanoyl]-N-[(1S)-2-[(4-methoxyphenyl)methylamino]-1-methyl-2-oxo-ethyl]piperidine-4-carboxamide
  • 1-[(2S)-2-amino-4-(methylthio)-1-oxobutyl]-N-[(1S)-2-[(4-methoxyphenyl)methylamino]-1-methyl-2-oxoethyl]-4-piperidinecarboxamide
  • 1-[(2S)-2-amino-4-(methylthio)butanoyl]-N-[(1S)-2-keto-2-[(4-methoxybenzyl)amino]-1-methyl-ethyl]isonipecotamide
  • 1-[(2S)-2-amino-4-methylsulfanyl-butanoyl]-N-[(2S)-1-[(4-methoxyphenyl)methylamino]-1-oxo-propan-2-yl]piperidine-4-carboxamide
  • STOCK1N-55365

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni brg-1 associated factor 0.1009 0.3655 0.6394
Brugia malayi hypothetical protein 0.0018 0.0008 0.002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0026 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0026 0.0069
Loa Loa (eye worm) hypothetical protein 0.0022 0.0021 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0023 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Schistosoma mansoni TRABID protein (C64 family) 0.0359 0.1262 0.2203
Echinococcus granulosus zinc finger protein Ran binding 0.0359 0.1262 0.1637
Onchocerca volvulus 0.0098 0.0302 0.0826
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0203 0.0554
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.002
Schistosoma mansoni hypothetical protein 0.1009 0.3655 0.6394
Echinococcus multilocularis SWI:SNF matrix associated 0.1009 0.3655 0.3652
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0073 0.0199
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0251 0.0684
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0073 0.0199
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Schistosoma mansoni DNA polymerase eta 0.0023 0.0027 0.0039
Plasmodium falciparum acyl-CoA synthetase 0.004 0.0089 0.0222
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.0167 0.0456
Loa Loa (eye worm) hypothetical protein 0.0159 0.0526 0.1438
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0054 0.0139 0.2049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0309 0.0534
Brugia malayi MH2 domain containing protein 0.0253 0.0872 0.2385
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0309 0.0397
Leishmania major hypothetical protein, conserved 0.0359 0.1262 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0035 0.0095
Leishmania major hypothetical protein, conserved 0.0018 0.0009 0.0063
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0081 0.0341
Schistosoma mansoni hypothetical protein 0.1009 0.3655 0.6394
Brugia malayi nuclear receptor NHR-88 0.0023 0.0026 0.0069
Echinococcus granulosus GPCR family 2 0.005 0.0126 0.0158
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1009 0.3655 1
Plasmodium vivax ataxin-2 like protein, putative 0.0018 0.0009 0.0002
Echinococcus granulosus tar DNA binding protein 0.0073 0.0209 0.0266
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0203 0.111
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0209 0.0569
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.002 0.0016
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0092 0.0249
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0126 0.0158
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0309 0.0305
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0028 0.0045 0.0114
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0018 0.0008 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0031 0.0026
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0018 0.0008 0.002
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0026 0.0038
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0102 0.0276
Schistosoma mansoni mind bomb 0.0018 0.0008 0.0007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0053 0.0048
Echinococcus granulosus neuropeptide s receptor 0.0531 0.1896 0.2463
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.0053
Brugia malayi RING zinc finger protein 0.0018 0.0008 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.002
Echinococcus granulosus cpg binding protein 0.0104 0.0323 0.0415
Loa Loa (eye worm) hypothetical protein 0.0037 0.0077 0.0209
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.018 0.0964
Echinococcus granulosus lamin dm0 0.0062 0.0167 0.0212
Echinococcus granulosus chromobox protein 1 0.0084 0.0251 0.0321
Entamoeba histolytica hypothetical protein 0.0041 0.0092 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0081 0.0341
Trypanosoma cruzi hypothetical protein, conserved 0.0359 0.1262 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0027 0.0206
Onchocerca volvulus 0.0308 0.1074 0.2938
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0028 0.0045 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0008 0.0058
Brugia malayi TAR-binding protein 0.0073 0.0209 0.0569
Brugia malayi Zinc finger protein 183 homolog 0.0018 0.0008 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0081 0.0341
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0018 0.0008 0.0004
Leishmania major DNA polymerase kappa, putative 0.0023 0.0027 0.0206
Entamoeba histolytica hypothetical protein 0.0024 0.0028 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0139 0.2049
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0028 0.0045 0.0114
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0203 0.0554
Onchocerca volvulus RING finger protein 141 homolog 0.0018 0.0008 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0026 0.0069
Mycobacterium tuberculosis Conserved protein 0.0071 0.0203 0.111
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.018 0.279
Brugia malayi Cytochrome P450 family protein 0.0028 0.0045 0.0121
Entamoeba histolytica hypothetical protein 0.0041 0.0092 0.0733
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.124 0.3393
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0209 0.0358
Leishmania major hypothetical protein, conserved 0.0018 0.0008 0.0058
Onchocerca volvulus 0.0071 0.0203 0.0554
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0028 0.0045 0.0114
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0018 0.0008 0.0058
Brugia malayi brahma associated protein 60 kDa 0.1009 0.3655 1
Brugia malayi RNA, U transporter 1 0.0083 0.0247 0.0675
Toxoplasma gondii histone lysine methyltransferase SET1 0.0186 0.0626 0.1695
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0102 0.08
Loa Loa (eye worm) CYP4Cod1 0.005 0.0125 0.034
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0203 0.111
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0026 0.0069
Brugia malayi B-box zinc finger family protein 0.0018 0.0008 0.002
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0019 0.0012 0.0008
Trypanosoma cruzi hypothetical protein 0.0018 0.0008 0.0058
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0027 0.0071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0026 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0209 0.0358
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1009 0.3655 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0031 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Echinococcus granulosus dna polymerase kappa 0.0023 0.0027 0.0029
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.02 0.0678 0.1853
Toxoplasma gondii cytochrome p450 superfamily protein 0.0028 0.0045 0.0101
Echinococcus multilocularis tumor protein p63 0.2103 0.7685 0.7684
Schistosoma mansoni hypothetical protein 0.0359 0.1262 0.2203
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0018 0.0008 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0139 0.0379
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0209 0.0569
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0139 0.2049
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0208 0.0708 0.1233
Schistosoma mansoni zinc finger protein 0.0359 0.1262 0.2203
Entamoeba histolytica Ran family GTPase 0.0022 0.002 0.0157
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0018 0.0008 0.0005
Trypanosoma cruzi cytochrome P450, putative 0.005 0.0125 0.0986
Onchocerca volvulus 0.0018 0.0008 0.002
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0028 0.0045 0.0114
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0028 0.0045 0.033
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0054 0.0139 0.2049
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0069
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0028 0.0075
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0028 0.0045 0.033
Trypanosoma brucei hypothetical protein, conserved 0.0359 0.1262 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0073 0.0199
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.124 0.3393
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0126 0.0158
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0026 0.0021
Echinococcus multilocularis SWI:SNF matrix associated 0.1009 0.3655 0.3652
Trypanosoma cruzi hypothetical protein 0.0018 0.0008 0.0058
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0114 0.0311
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.0665 0.1819
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0026 0.0028
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0102 0.0276
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.002 0.0033
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0026 0.0021
Loa Loa (eye worm) RNA binding protein 0.0073 0.0209 0.0569
Schistosoma mansoni alpha glucosidase 0.0044 0.0102 0.017
Loa Loa (eye worm) fli-1 protein 0.025 0.0862 0.2358
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0139 0.2049
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0026 0.0038
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0018 0.0008 0.0005
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.0665 0.1819
Onchocerca volvulus 0.0018 0.0008 0.002
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0665 0.0661
Leishmania major cytochrome p450-like protein 0.0028 0.0045 0.0349
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.018 0.0308
Brugia malayi Fli-1 protein 0.025 0.0862 0.2358
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0203 0.0554
Echinococcus granulosus tumor protein p63 0.2103 0.7685 1
Onchocerca volvulus 0.0359 0.1262 0.3452
Echinococcus multilocularis snurportin 1 0.0313 0.1092 0.1088
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0026 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0027 0.0211
Loa Loa (eye worm) hypothetical protein 0.0308 0.1074 0.2938
Brugia malayi MH2 domain containing protein 0.0017 0.0004 0.001
Echinococcus multilocularis neuropeptide receptor A26 0.0531 0.1896 0.1893
Onchocerca volvulus 0.0022 0.0023 0.0062
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0009 0.0002
Leishmania major cytochrome p450-like protein 0.0028 0.0045 0.0349
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0008 0.0058
Trypanosoma brucei unspecified product 0.0023 0.0027 0.0211
Onchocerca volvulus 0.0037 0.0077 0.0209
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0026 0.0038
Loa Loa (eye worm) hypothetical protein 0.0071 0.0203 0.0554
Echinococcus multilocularis 0.0018 0.0008 0.0004
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0018 0.0008 0.0059
Plasmodium vivax hypothetical protein, conserved 0.1009 0.3655 1
Onchocerca volvulus 0.0018 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.004 0.0089 0.0242
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0026 0.0028
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0035 0.0095
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0028 0.0045 0.0114
Leishmania major hypothetical protein 0.0018 0.0008 0.0058
Loa Loa (eye worm) hypothetical protein 0.0359 0.1262 0.3452
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0027 0.0211
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0251 0.0684
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0359 0.1262 1
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0018 0.0008 0.0007
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0027 0.0206
Echinococcus granulosus geminin 0.0918 0.3322 0.4319
Brugia malayi N-terminal motif family protein 0.02 0.0678 0.1853
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1009 0.3655 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0026 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0026 0.0069
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0027 0.0071
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0203 0.0554
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0102 0.0276
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0209 0.0569
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0008 0.0059
Trypanosoma cruzi WLM domain containing protein, putative 0.0359 0.1262 1
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0102 0.08
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0064
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0359 0.1262 0.3438
Loa Loa (eye worm) transcription factor SMAD2 0.0253 0.0872 0.2385
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0203 0.0259
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0359 0.1262 0.3452
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0008 0.0058
Onchocerca volvulus 0.0359 0.1262 0.3452
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0027 0.0211
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.004 0.0089 0.0392
Toxoplasma gondii LsmAD domain-containing protein 0.0018 0.0009 0.0002
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0008 0.0059
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0069
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0026 0.0069
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0102 0.0097
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0102 0.0276
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0159 0.0526 0.1438
Brugia malayi hypothetical protein 0.0018 0.0008 0.002
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0023 0.0042
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0359 0.1262 0.3452
Brugia malayi Importin beta-1 subunit 0.0029 0.0049 0.0131
Trypanosoma cruzi WLM domain containing protein, putative 0.0359 0.1262 1
Brugia malayi beta-lactamase family protein 0.0071 0.0203 0.0554
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0139 0.0708
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0092 0.0114
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0131
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0028 0.0045 0.0114
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0139 0.2049
Leishmania major hypothetical protein, conserved 0.0018 0.0008 0.0058
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0128 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.0009 0.0063
Loa Loa (eye worm) histone methyltransferase 0.003 0.0053 0.0142
Brugia malayi MH1 domain containing protein 0.0017 0.0004 0.001
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0203 0.0535
Loa Loa (eye worm) hypothetical protein 0.0054 0.0139 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0023 0.006
Loa Loa (eye worm) hypothetical protein 0.0071 0.0203 0.0554
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0031 0.0046
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0026 0.0038
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0054 0.0139 0.2049
Trypanosoma brucei predicted zinc finger protein 0.0018 0.0008 0.0064
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0028 0.0045 0.0114
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0073 0.0199
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0064
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0102 0.0276
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0028 0.0045 0.033
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0576 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0309 0.0397
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0028 0.0045 0.0114
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0026 0.0069
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0064
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.124 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0026 0.0028
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0359 0.1262 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0102 0.0814
Loa Loa (eye worm) hypothetical protein 0.004 0.0089 0.0242
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0023 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0023 0.006
Brugia malayi hypothetical protein 0.0041 0.0092 0.0249
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0203 0.0199
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.0154
Brugia malayi brahma associated protein 60 kDa 0.1009 0.3655 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.018 0.0308
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0026 0.0069
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0128 0.0347
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0114 0.0311
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0104 0.0175
Echinococcus granulosus importin subunit beta 1 0.0029 0.0049 0.0058
Leishmania major cytochrome p450-like protein 0.005 0.0125 0.0986
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Loa Loa (eye worm) hypothetical protein 0.02 0.0678 0.1853
Onchocerca volvulus 0.0114 0.036 0.0983
Trichomonas vaginalis conserved hypothetical protein 0.1009 0.3655 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0064
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0126 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0027 0.0211
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0576 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0126 0.0343
Schistosoma mansoni hypothetical protein 0.0028 0.0045 0.0071
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0102 0.0257
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0124
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.124 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Mycobacterium tuberculosis Conserved protein 0.0071 0.0203 0.111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0027 0.0206
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0018 0.0008 0.0005
Onchocerca volvulus 0.0359 0.1262 0.3452
Brugia malayi Latrophilin receptor protein 2 0.005 0.0126 0.0343
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0023 0.0019
Schistosoma mansoni rab6-interacting 0.0022 0.0023 0.0034
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0028 0.0075
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0102 0.0276
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Onchocerca volvulus 0.0062 0.0167 0.0456
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0028 0.0045 0.033
Entamoeba histolytica hypothetical protein 0.0041 0.0092 0.0733
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0028 0.0045 0.0114
Leishmania major hypothetical protein, conserved 0.0018 0.0008 0.0058
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0359 0.1262 0.1258
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0027 0.0206
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0102 0.0814
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.002 0.0021
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1009 0.3655 1
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.018 0.0471
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0023 0.0019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0073 0.0199
Echinococcus multilocularis ring and YY1 binding protein 0.0359 0.1262 0.1258
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0064
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0062 0.0168
Onchocerca volvulus 0.0023 0.0026 0.0069
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0023 0.0025
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0203 0.111
Brugia malayi Cytochrome P450 family protein 0.005 0.0125 0.034
Entamoeba histolytica acyl-coA synthetase, putative 0.0054 0.0139 0.1117
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0023 0.0042
Brugia malayi Zinc finger, C2H2 type family protein 0.0018 0.0008 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0008 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Brugia malayi hypothetical protein 0.0022 0.0023 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0027 0.0211
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0028 0.0045 0.033
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0092 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0026 0.0069
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0045 0.0349
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0026 0.0069
Schistosoma mansoni hypothetical protein 0.1009 0.3655 0.6394
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Loa Loa (eye worm) RING finger protein 20 0.0018 0.0008 0.002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0026 0.0021
Schistosoma mansoni zinc finger protein 0.0018 0.0008 0.0007
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0028 0.0045 0.033
Brugia malayi chromobox protein homolog 3 0.0047 0.0114 0.0311
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.018 0.279
Schistosoma mansoni lamin 0.0062 0.0167 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0026 0.0028
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0026 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0359 0.1262 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0359 0.1262 0.3452
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0203 0.1605
Loa Loa (eye worm) CHromoDomain protein family member 0.0019 0.0012 0.0031
Echinococcus multilocularis GPCR, family 2 0.005 0.0126 0.0122
Schistosoma mansoni loxhd1 0.0022 0.0023 0.0034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0203 0.0348
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0028 0.0045 0.033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0027 0.0206
Echinococcus multilocularis 0.0028 0.0045 0.004
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0023 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0026 0.0069
Mycobacterium ulcerans lipase LipD 0.0071 0.0203 0.3213
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.002
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0023 0.0025
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0203 0.111
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0028 0.0045 0.0114
Loa Loa (eye worm) hypothetical protein 0.003 0.005 0.0135
Brugia malayi cytochrome P450 0.0028 0.0045 0.0121
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0092 0.0088
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0028 0.0218
Echinococcus multilocularis lamin dm0 0.0062 0.0167 0.0163
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0139 0.1098
Brugia malayi hypothetical protein 0.0018 0.0008 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0309 0.0305
Schistosoma mansoni ets-related 0.025 0.0862 0.1503
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0209 0.0358
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0027 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Schistosoma mansoni hypothetical protein 0.0022 0.0023 0.0034
Schistosoma mansoni hypothetical protein 0.005 0.0126 0.0213
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0027 0.0071
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0139 0.1098
Loa Loa (eye worm) brahma associated protein 0.1009 0.3655 1
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0125 0.034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0309 0.0534
Loa Loa (eye worm) hypothetical protein 0.0359 0.1262 0.3452
Schistosoma mansoni fusion 0.0359 0.1262 0.2203
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0027 0.0209
Schistosoma mansoni rnf5 0.0018 0.0008 0.0007
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0018 0.0008 0.002
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0028 0.0045 0.033
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0359 0.1262 0.1637
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0359 0.1262 0.1258
Brugia malayi Heterochromatin protein 1 0.0084 0.0251 0.0684
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0008 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Schistosoma mansoni cpg binding protein 0.0104 0.0323 0.0558
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0159 0.0526 0.1438
Onchocerca volvulus 0.0018 0.0008 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0309 0.0534
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0026 0.0038
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0203 0.0554
Leishmania major DNA polymerase eta, putative 0.0023 0.0027 0.0206
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1009 0.3655 0.4753
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0026 0.0028
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0203 0.1609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.124 0.3393
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0018 0.0008 0.0004
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0027 0.0022
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0053 0.0063
Onchocerca volvulus 0.0018 0.0008 0.002
Schistosoma mansoni hypothetical protein 0.0918 0.3322 0.5811
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0069
Onchocerca volvulus Putative RING finger protein 207 0.0018 0.0008 0.002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0126 0.0122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.124 0.3393
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0082 0.0244 0.0667
Loa Loa (eye worm) hypothetical protein 0.0032 0.0058 0.0158
Echinococcus granulosus ring finger protein 113a 0.0018 0.0008 0.0005
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0064
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0203 0.2982
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0072 0.0205 0.0558
Schistosoma mansoni peter pan-related 0.0018 0.0008 0.0007
Onchocerca volvulus 0.0054 0.0139 0.0379
Brugia malayi Neuralized family protein 0.0018 0.0008 0.002
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0018 0.0008 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Echinococcus multilocularis microtubule associated protein 2 0.1568 0.5713 0.5711
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0008 0.0059
Brugia malayi Cytochrome P450 family protein 0.005 0.0125 0.034
Brugia malayi RNA binding protein 0.0073 0.0209 0.0569
Brugia malayi beta-lactamase family protein 0.0071 0.0203 0.0554
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0008 0.0058
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0209 0.0204
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0028 0.0045 0.0349
Schistosoma mansoni ran 0.0022 0.002 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0073 0.0199
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0027 0.0211
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0031 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0028 0.0045 0.0114
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.018 0.0229
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0139 0.0379
Brugia malayi Cytochrome P450 family protein 0.0072 0.0205 0.0558
Onchocerca volvulus Protein neuralized homolog 0.0018 0.0008 0.002
Echinococcus granulosus dna polymerase eta 0.0023 0.0027 0.0029
Loa Loa (eye worm) CXXC zinc finger family protein 0.0098 0.0302 0.0826
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0045 0.0349
Leishmania major hypothetical protein, conserved 0.0018 0.0008 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0023 0.006
Leishmania major hypothetical protein, conserved 0.0018 0.0008 0.0058
Loa Loa (eye worm) hypothetical protein 0.0359 0.1262 0.3452
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0018 0.0008 0.0064
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0026 0.0038
Loa Loa (eye worm) RiNg Finger protein family member 0.0018 0.0008 0.002
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0102 0.0276
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.002 0.0098
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0083 0.0225
Loa Loa (eye worm) hypothetical protein 0.0054 0.0139 0.0379
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0027 0.0206
Echinococcus granulosus ring finger protein 170 0.0018 0.0008 0.0005
Schistosoma mansoni cpg binding protein 0.0098 0.0302 0.0522
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0026 0.0021
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0028 0.0045 0.033
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0359 0.1262 0.3452
Brugia malayi Ets-domain containing protein 0.0082 0.0244 0.0667
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0049 0.0385
Echinococcus granulosus dnaJ subfamily B 0.1399 0.5092 0.6624
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0004 0.001
Onchocerca volvulus 0.0018 0.0008 0.002
Schistosoma mansoni chromobox protein 0.0084 0.0251 0.0432
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0008 0.0058
Loa Loa (eye worm) cytochrome P450 0.0028 0.0045 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0027 0.0211
Schistosoma mansoni chromobox protein 0.0084 0.0251 0.0432
Echinococcus multilocularis zinc finger protein Ran binding 0.0359 0.1262 0.1258
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0026 0.0069
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.002
Echinococcus multilocularis dna polymerase eta 0.0023 0.0027 0.0022
Echinococcus multilocularis chromobox protein 1 0.0084 0.0251 0.0246
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0004 0.001
Onchocerca volvulus 0.1009 0.3655 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0026 0.0021
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0018 0.0008 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.124 0.3393
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0018 0.0008 0.0004
Echinococcus granulosus neuropeptide receptor A26 0.0531 0.1896 0.2463
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0028 0.0045 0.033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.124 0.3393
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0026 0.0069
Leishmania major hypothetical protein, conserved 0.0018 0.0008 0.0058
Schistosoma mansoni lamin 0.0062 0.0167 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0018 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0071 0.0203 0.0554
Trichomonas vaginalis ankyrin, putative 0.0018 0.0008 0.002
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0008 0.0059
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0028 0.0045 0.033
Schistosoma mansoni hypothetical protein 0.0109 0.0341 0.059
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0018 0.0008 0.002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.0139 0.1778
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0049 0.0044
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0026 0.0069
Brugia malayi ecdysteroid receptor 0.0023 0.0026 0.0069
Leishmania major hypothetical protein, conserved 0.0359 0.1262 1
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0027 0.0211
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0027 0.0029
Brugia malayi steroid hormone receptor 0.0023 0.0026 0.0069
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0028 0.0045 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0027 0.0211
Echinococcus granulosus snurportin 1 0.0313 0.1092 0.1416
Loa Loa (eye worm) hypothetical protein 0.0071 0.0203 0.0554
Mycobacterium ulcerans hypothetical protein 0.0054 0.0139 0.2049
Echinococcus multilocularis geminin 0.0918 0.3322 0.3319
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0102 0.08
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0028 0.0045 0.0114
Leishmania major hypothetical protein, conserved 0.0359 0.1262 1
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0203 0.111
Echinococcus granulosus GA binding protein alpha chain 0.0082 0.0244 0.0313
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0027 0.0071
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0026 0.0069
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0359 0.1262 1
Schistosoma mansoni hypothetical protein 0.0918 0.3322 0.5811
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0018 0.0008 0.0005
Echinococcus multilocularis chromobox protein 1 0.0084 0.0251 0.0246
Echinococcus granulosus chromobox protein 1 0.0084 0.0251 0.0321
Echinococcus multilocularis neuropeptide s receptor 0.0531 0.1896 0.1893
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0028 0.0045 0.0114
Trichomonas vaginalis esterase, putative 0.0071 0.0203 0.0554
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0028 0.0045 0.033
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0007
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Schistosoma mansoni intermediate filament proteins 0.0062 0.0167 0.0286
Trichomonas vaginalis ion channel nompc, putative 0.0018 0.0008 0.002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.0154
Trypanosoma cruzi PAB1-binding protein , putative 0.0018 0.0009 0.0063
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0576 0.3454
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0026 0.0069
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1009 0.3655 0.3652
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0018 0.0008 0.0005
Mycobacterium leprae Probable lipase LipE 0.0071 0.0203 0.2982
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0125 0.034
Trichomonas vaginalis helicase, putative 0.0022 0.0023 0.006
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0062
Trichomonas vaginalis ran, putative 0.0022 0.002 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0203 0.1605
Schistosoma mansoni importin beta-1 0.0029 0.0049 0.0078
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0028 0.0045 0.033
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0026 0.0069
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0001 0.0005
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0359 0.1262 1
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0026 0.0038
Brugia malayi RING finger protein 20 0.0018 0.0008 0.002
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0102 0.0276
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0028 0.0045 0.0114
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0019 0.0012 0.0014
Leishmania major hypothetical protein, conserved 0.0018 0.0008 0.0058
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1009 0.3655 1
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0018 0.0008 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.0139 0.1117
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0018 0.0008 0.002
Leishmania major hypothetical protein, conserved 0.0071 0.0203 0.1605
Brugia malayi Doublecortin family protein 0.0022 0.0023 0.0062
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0028 0.0075
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0126 0.0343
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0081 0.0341
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0028 0.0045 0.033
Leishmania major hypothetical protein, conserved 0.0018 0.0008 0.0058
Loa Loa (eye worm) Smad1 0.0017 0.0004 0.001
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0007
Echinococcus granulosus lamin 0.0062 0.0167 0.0212
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.005 0.0125 0.1793
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.0139 0.1778
Trypanosoma brucei glucosidase, putative 0.0044 0.0102 0.0805
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0029 0.0079
Schistosoma mansoni lipoxygenase 0.0094 0.0286 0.0494
Leishmania major GTP-binding protein, putative 0.0022 0.002 0.0154
Loa Loa (eye worm) hypothetical protein 0.006 0.0163 0.0445
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Loa Loa (eye worm) intermediate filament protein 0.0062 0.0167 0.0456
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0027 0.0071
Loa Loa (eye worm) hypothetical protein 0.0022 0.0023 0.0062
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0102 0.0276
Brugia malayi Ets-domain containing protein 0.0082 0.0244 0.0667
Trypanosoma cruzi hypothetical protein, conserved 0.0359 0.1262 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0064
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.124 1
Echinococcus multilocularis lamin 0.0062 0.0167 0.0163
Echinococcus granulosus Zinc finger RanBP2 type 0.0359 0.1262 0.1637
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0026 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.0341 0.0931
Schistosoma mansoni cpg binding protein 0.0104 0.0323 0.0558
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0203 0.3213
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0064
Echinococcus multilocularis cpg binding protein 0.0104 0.0323 0.0319
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0008 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0064 0.0173
Echinococcus granulosus intermediate filament protein 0.0062 0.0167 0.0212
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0251 0.0684
Giardia lamblia DINP protein human, muc B family 0.0023 0.0027 0.0151
Brugia malayi beta-lactamase 0.0071 0.0203 0.0554
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.004 0.0089 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0026 0.0069
Brugia malayi MH2 domain containing protein 0.0017 0.0004 0.001
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.005 0.0046
Schistosoma mansoni RNA binding protein 0.0359 0.1262 0.2203
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0028 0.0045 0.0349
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0026 0.0038
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0203 0.0554
Schistosoma mansoni hypothetical protein 0.005 0.0126 0.0213
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0062 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0064 0.0173
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0027 0.0211
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0026 0.0038
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0028 0.0045 0.033
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.0139 0.1098
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0134 0.0435 0.0431
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0008 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0008 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.124 0.3393
Entamoeba histolytica SPRY domain protein 0.0018 0.0008 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0026 0.0069
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0203 0.0554
Loa Loa (eye worm) MH2 domain-containing protein 0.0253 0.0872 0.2385
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0027 0.0211
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0124
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0455 0.1616 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.0167 0.0456
Onchocerca volvulus 0.0359 0.1262 0.3452
Echinococcus multilocularis ring finger protein 170 0.0018 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0073 0.0199
Trichomonas vaginalis ankyrin, putative 0.0018 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0054 0.0139 0.0379
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0028 0.0045 0.0355
Schistosoma mansoni hypothetical protein 0.0313 0.1092 0.1905
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0092 0.0087
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Schistosoma mansoni coup transcription factor 0.0023 0.0026 0.0038
Schistosoma mansoni ran 0.0022 0.002 0.0028
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0026 0.0021
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0018 0.0008 0.002
Schistosoma mansoni hypothetical protein 0.1399 0.5092 0.8911
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0026 0.0028
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0134 0.0435 0.0561
Entamoeba histolytica hypothetical protein 0.0018 0.0008 0.0059
Echinococcus multilocularis musashi 0.0062 0.0167 0.0163
Loa Loa (eye worm) hypothetical protein 0.0359 0.1262 0.3452
Leishmania major hypothetical protein, conserved 0.0018 0.0008 0.0058
Brugia malayi Smad1 0.0017 0.0004 0.001
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.0309 0.0844
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0049 0.0385
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1009 0.3655 1
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0026 0.0069
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0026 0.0028
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.002 0.0033
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.018 0.279
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.0309 0.0844
Trypanosoma cruzi cytochrome P450, putative 0.005 0.0125 0.0986
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0023 0.006
Brugia malayi hypothetical protein 0.0018 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0069
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0027 0.0039
Leishmania major hypothetical protein, conserved 0.0018 0.0008 0.0058
Trypanosoma brucei PAB1-binding protein , putative 0.0018 0.0009 0.0069
Loa Loa (eye worm) beta-lactamase 0.0071 0.0203 0.0554
Brugia malayi CXXC zinc finger family protein 0.0098 0.0302 0.0826
Schistosoma mansoni hypothetical protein 0.0041 0.0092 0.0153
Echinococcus granulosus RING finger protein 185 0.0018 0.0008 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0159 0.0526 0.1438
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0104 0.0175
Schistosoma mansoni hypothetical protein 0.005 0.0126 0.0213
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0051 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0102 0.0276
Echinococcus multilocularis SWI:SNF matrix associated 0.1009 0.3655 0.3652
Leishmania major hypothetical protein, conserved 0.0018 0.0008 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0023 0.006
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.018 0.142
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0023 0.006
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0092 0.0153
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0019 0.0012 0.001
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0054 0.0139 0.0708
Leishmania major DNA repair protein-like protein 0.0018 0.0008 0.0058
Brugia malayi hypothetical protein 0.0018 0.0008 0.002
Chlamydia trachomatis SWIB complex protein 0.1009 0.3655 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0031 0.0034
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.0665 0.0861
Echinococcus multilocularis RUN 0.0022 0.0023 0.0019
Schistosoma mansoni alpha-glucosidase 0.0169 0.0564 0.0981
Echinococcus granulosus cell growth regulator with ring finger domain 0.0018 0.0008 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0026 0.0038
Onchocerca volvulus 0.0022 0.0023 0.0062
Onchocerca volvulus 0.0071 0.0203 0.0554
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0028 0.0045 0.033
Trypanosoma brucei cytochrome P450, putative 0.005 0.0125 0.0991
Leishmania major hypothetical protein, conserved 0.0359 0.1262 1
Trichomonas vaginalis hypothetical protein 0.0018 0.0008 0.002
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0359 0.1262 0.3438
Trypanosoma brucei hypothetical protein, conserved 0.0359 0.1262 1
Trichomonas vaginalis ankyrin, putative 0.0018 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0069
Brugia malayi intermediate filament protein 0.0062 0.0167 0.0456
Brugia malayi YY1-associated factor 2 0.0359 0.1262 0.3452
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0028 0.0045 0.033
Schistosoma mansoni lipoxygenase 0.0134 0.0435 0.0755
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0209 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0023 0.006
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0027 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0027 0.0211
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0102 0.0276
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0027 0.0211
Leishmania major hypothetical protein, conserved 0.0359 0.1262 1
Brugia malayi nuclear hormone receptor 0.0023 0.0026 0.0069
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0069
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0139 0.0379
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0359 0.1262 1
Echinococcus multilocularis RING finger protein 185 0.0018 0.0008 0.0004
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0359 0.1262 1
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.124 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0026 0.0069
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0203 0.0348
Schistosoma mansoni gabp alpha 0.0082 0.0244 0.0421
Plasmodium falciparum importin beta, putative 0.0029 0.0049 0.0111
Loa Loa (eye worm) hypothetical protein 0.004 0.0089 0.0242
Loa Loa (eye worm) hypothetical protein 0.005 0.0126 0.0343
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0026 0.0038
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0026 0.0069
Loa Loa (eye worm) hypothetical protein 0.0359 0.1262 0.3452
Toxoplasma gondii ABC1 family protein 0.0071 0.0203 0.0535
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0102 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0026 0.0069
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0018 0.0008 0.002
Trypanosoma brucei DNA repair protein, putative 0.0018 0.0008 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0026 0.0028
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.005 0.006
Plasmodium vivax importin-beta 2, putative 0.0029 0.0049 0.0111
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0028 0.0045 0.0114
Schistosoma mansoni peter pan-related 0.0018 0.0008 0.0007
Brugia malayi hypothetical protein 0.0022 0.0023 0.0062
Echinococcus granulosus RUN 0.0022 0.0023 0.0025
Plasmodium vivax acyl-CoA synthetase, putative 0.004 0.0089 0.0222
Schistosoma mansoni polycystin 1-related 0.0022 0.0023 0.0034
Echinococcus multilocularis dnaJ subfamily B 0.1399 0.5092 0.5089
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0064
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0665 0.0661
Loa Loa (eye worm) hypothetical protein 0.0062 0.0167 0.0456
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0008 0.0059
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0018 0.0008 0.0004
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0018 0.0008 0.0005
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.0139 0.1117
Schistosoma mansoni cytochrome P450 0.0028 0.0045 0.0071
Chlamydia trachomatis DNA topoisomerase I 0.1009 0.3655 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0027 0.0022
Schistosoma mansoni cellular tumor antigen P53 0.0308 0.1074 0.1874
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0203 0.3213
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0359 0.1262 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0073 0.0199
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0026 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0028 0.0045 0.033
Leishmania major hypothetical protein, unknown function 0.0018 0.0008 0.0058
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0049 0.0111
Mycobacterium ulcerans hypothetical protein 0.0071 0.0203 0.3213
Brugia malayi hypothetical protein 0.0018 0.0009 0.0022
Schistosoma mansoni microtubule-associated protein tau 0.1568 0.5713 1
Echinococcus granulosus SWI:SNF matrix associated 0.1009 0.3655 0.4753
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0018 0.0008 0.002
Toxoplasma gondii ran binding protein 0.0359 0.1262 0.3438
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0028 0.0045 0.0114
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0008 0.0059
Loa Loa (eye worm) hypothetical protein 0.0071 0.0203 0.0554
Mycobacterium ulcerans fatty-acid-CoA ligase 0.004 0.0089 0.1136
Echinococcus granulosus ring and YY1 binding protein 0.0359 0.1262 0.1637
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0203 0.111
Loa Loa (eye worm) hypothetical protein 0.0109 0.0341 0.0931
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0023 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Onchocerca volvulus 0.0071 0.0203 0.0554
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0359 0.1262 0.3452
Plasmodium falciparum ataxin-2 like protein, putative 0.0018 0.0009 0.0002
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0028 0.0045 0.0114
Echinococcus multilocularis GA binding protein alpha chain 0.0082 0.0244 0.024
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.1092 0.2985
Echinococcus multilocularis ring finger protein 113a 0.0018 0.0008 0.0004
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.018 0.0176
Entamoeba histolytica hypothetical protein 0.0041 0.0092 0.0733
Brugia malayi MH1 domain containing protein 0.0017 0.0004 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0114 0.0311
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.002 0.016
Echinococcus granulosus microtubule associated protein 2 0.1568 0.5713 0.7433
Schistosoma mansoni hypothetical protein 0.005 0.0126 0.0213
Mycobacterium ulcerans beta-lactamase 0.0071 0.0203 0.3213
Brugia malayi SWIB/MDM2 domain containing protein 0.1009 0.3655 1
Onchocerca volvulus 0.0062 0.0167 0.0456
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0203 0.111
Leishmania major hypothetical protein, conserved 0.0018 0.0008 0.0058
Trypanosoma brucei ring finger containing protein 0.0018 0.0008 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0026 0.0069
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0026 0.0038
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0092 0.0249
Schistosoma mansoni alpha-glucosidase 0.0169 0.0564 0.0981
Leishmania major hypothetical protein, conserved 0.0018 0.0008 0.0058
Brugia malayi hypothetical protein 0.0018 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.007 0.02 0.0546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0026 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0209 0.0358
Loa Loa (eye worm) hypothetical protein 0.0071 0.0203 0.0554
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0083 0.0225
Brugia malayi CHD4 protein 0.0019 0.0012 0.0031
Schistosoma mansoni rab6-interacting 0.0022 0.0023 0.0034
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0028 0.0045 0.033
Mycobacterium tuberculosis Conserved protein 0.0071 0.0203 0.111
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0028 0.0045 0.033
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0023 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.124 0.3393
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0008 0.0064
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0018 0.0008 0.002
Schistosoma mansoni ring finger protein 151 0.0018 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.004 0.0089 0.0242
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0028 0.0045 0.0114
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0008 0.002
Leishmania major importin beta-1 subunit, putative 0.0024 0.0028 0.0218
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0128 0.0347
Echinococcus granulosus cytochrome P450 2K1 0.0028 0.0045 0.0053

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0052 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.4147 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.5171 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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