Detailed information for compound 1549217

Basic information

Technical information
  • TDR Targets ID: 1549217
  • Name: N'-[4,6-bis(diethylamino)-1,3,5-triazin-2-yl] benzohydrazide
  • MW: 357.453 | Formula: C18H27N7O
  • H donors: 2 H acceptors: 4 LogP: 3.84 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1nc(NNC(=O)c2ccccc2)nc(n1)N(CC)CC)CC
  • InChi: 1S/C18H27N7O/c1-5-24(6-2)17-19-16(20-18(21-17)25(7-3)8-4)23-22-15(26)14-12-10-9-11-13-14/h9-13H,5-8H2,1-4H3,(H,22,26)(H,19,20,21,23)
  • InChiKey: ZDKDXJFGQOYKRT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-[4,6-bis(diethylamino)-s-triazin-2-yl]benzohydrazide
  • NSC99860

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0022 0.0022
Trypanosoma cruzi polo-like protein kinase, putative 0.0042 0.0201 0.4989
Schistosoma mansoni smad 0.001 0.0021 0.0021
Trypanosoma cruzi cytochrome p450-like protein, putative 0.001 0.0021 0.0449
Entamoeba histolytica casein kinase 1, putative 0.0041 0.0192 0.0723
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0014 0.0042 0.0042
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0022 0.0022
Entamoeba histolytica deoxycytidyl transferase, putative 0.0024 0.0097 0.0297
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0022 0.0022
Brugia malayi Doublecortin family protein 0.0304 0.1644 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0035 0.0084
Brugia malayi Phospholipase A2 family protein 0.012 0.0631 0.3828
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0022 0.0022
Plasmodium vivax heat shock protein 86, putative 0.0014 0.0047 0.0263
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0415 0.2257 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0042 0.0201 0.1068
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0217 0.0217
Schistosoma mansoni adenoreceptor 0.001 0.0022 0.0022
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0035 0.0035
Leishmania major histone deacetylase, putative 0.0039 0.0183 0.4527
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0027 0.0117 0.0117
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0024 0.0097 0.0514
Echinococcus multilocularis casein kinase I alpha 0.0041 0.0192 0.0192
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0022 0.0022
Brugia malayi Cytochrome P450 family protein 0.0016 0.0055 0.0316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0022 0.0022
Mycobacterium ulcerans DNA polymerase IV 0.0035 0.0162 0.1488
Leishmania major p-glycoprotein 0.0014 0.0042 0.0981
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.001 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0182
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0022 0.0022
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0014 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0167
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.001 0.0021 0.0025
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0003 0.0003
Schistosoma mansoni multidrug resistance protein 0.0014 0.0042 0.0042
Entamoeba histolytica heat shock protein 90, putative 0.0014 0.0047 0.0071
Trichomonas vaginalis chromobox protein, putative 0.0031 0.0138 0.0543
Loa Loa (eye worm) NADH dehydrogenase subunit 1 0.0017 0.0061 0.0325
Brugia malayi hypothetical protein 0.001 0.0022 0.012
Schistosoma mansoni biogenic amine receptor 0.001 0.0022 0.0022
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0042 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0035 0.0162 0.4006
Brugia malayi Smad1 0.001 0.0021 0.0112
Loa Loa (eye worm) hypothetical protein 0.008 0.0409 0.2177
Loa Loa (eye worm) heterochromatin protein 1 0.0031 0.0138 0.073
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0035 0.0194
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0042 0.0042
Brugia malayi ABC transporter family protein 0.0014 0.0042 0.024
Plasmodium falciparum ataxin-2 like protein, putative 0.0011 0.0025 0.0132
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0022 0.0022
Echinococcus granulosus g protein coupled receptor 0.001 0.0022 0.0022
Echinococcus granulosus casein kinase I alpha 0.0041 0.0192 0.0192
Brugia malayi Flap endonuclease-1 0.0012 0.0031 0.0171
Chlamydia trachomatis recombinase RecA 0.0048 0.0231 0.217
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0042 0.0042
Trichomonas vaginalis CK1 family protein kinase 0.0041 0.0192 0.0785
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0022 0.0022
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0399 1
Schistosoma mansoni microtubule-associated protein tau 0.0478 0.2605 0.2605
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0007 0.0003 0.0003
Schistosoma mansoni amine GPCR 0.001 0.0022 0.0022
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0012 0.0032 0.0071
Loa Loa (eye worm) cytochrome P450 0.001 0.0021 0.011
Trypanosoma brucei heat shock protein, putative 0.0014 0.0047 0.1091
Loa Loa (eye worm) doublecortin family protein 0.0304 0.1644 0.8762
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0012
Echinococcus multilocularis heat shock protein 90 0.0014 0.0047 0.0047
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0022 0.0022
Echinococcus granulosus heat shock protein 0.0014 0.0047 0.0047
Echinococcus multilocularis macrophage expressed protein 0.1528 0.8395 0.8395
Trichomonas vaginalis heat shock protein, putative 0.0011 0.003 0.0065
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0022 0.012
Echinococcus granulosus histone deacetylase 6 0.0039 0.0183 0.0183
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0022 0.0022
Echinococcus granulosus histone deacetylase 0.0039 0.0183 0.0183
Schistosoma mansoni hypothetical protein 0.0146 0.0771 0.0771
Leishmania major histone deacetylase, putative 0.0012 0.0032 0.0719
Leishmania major cytochrome p450-like protein 0.001 0.0021 0.0449
Schistosoma mansoni NADH dehydrogenase subunit 1 0.0017 0.0061 0.0061
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0035 0.0182
Brugia malayi polk-prov protein 0.0019 0.0072 0.0424
Brugia malayi Pre-SET motif family protein 0.0043 0.0203 0.1223
Brugia malayi casein kinase 1, delta 0.0041 0.0192 0.1152
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0022 0.0022
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0022 0.0022
Schistosoma mansoni opsin-like receptor 0.001 0.0022 0.0022
Plasmodium vivax casein kinase 1, putative 0.0041 0.0192 0.1148
Trypanosoma brucei histone deacetylase 3 0.0039 0.0183 0.4527
Schistosoma mansoni amine GPCR 0.001 0.0022 0.0022
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0042 0.0118
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0022 0.0022
Trypanosoma cruzi heat shock protein 85, putative 0.0014 0.0047 0.1091
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0022 0.0117
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0022 0.0022
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0035 0.0035
Brugia malayi hypothetical protein 0.0304 0.1644 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0182
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Echinococcus multilocularis smad 0.001 0.0021 0.0021
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0022 0.0022
Schistosoma mansoni opsin-like receptor 0.001 0.0022 0.0022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0035 0.0035
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0022 0.0022
Schistosoma mansoni rab6-interacting 0.0304 0.1644 0.1644
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0022 0.0022
Echinococcus granulosus microtubule associated protein 2 0.0478 0.2605 0.2605
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0078 0.0399 0.1656
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Brugia malayi Dopamine receptor 0.001 0.0022 0.012
Loa Loa (eye worm) histone deacetylase 7A 0.0039 0.0183 0.0971
Mycobacterium leprae Conserved hypothetical protein 0.0506 0.2756 1
Schistosoma mansoni histone deacetylase hda2 0.0012 0.0032 0.0032
Toxoplasma gondii histone deacetylase HDAC3 0.0012 0.0032 0.0318
Brugia malayi casein kinase I 0.0041 0.0192 0.1152
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0022 0.0117
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0019 0.007 0.0258
Onchocerca volvulus 0.0017 0.0061 0.0213
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0011 0.003 0.0036
Trypanosoma cruzi DNA repair protein, putative 0.0015 0.0048 0.1136
Echinococcus multilocularis dna polymerase kappa 0.0035 0.0162 0.0162
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0021 0.0021
Trypanosoma brucei unspecified product 0.0032 0.0146 0.3598
Echinococcus multilocularis histone deacetylase 6 0.0039 0.0183 0.0183
Leishmania major DNA polymerase kappa, putative 0.0026 0.0113 0.277
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0035 0.0035
Echinococcus multilocularis endoplasmin 0.0011 0.003 0.003
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0022 0.0022
Leishmania major cytochrome p450-like protein 0.001 0.0021 0.0449
Plasmodium falciparum LCCL domain-containing protein 0.0304 0.1644 1
Schistosoma mansoni endoplasmin 0.0014 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0035 0.0194
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0022 0.012
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0007 0.01
Plasmodium falciparum perforin-like protein 4 0.0169 0.0899 0.5458
Brugia malayi N-terminal motif family protein 0.008 0.0409 0.2474
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0035 0.0035
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0042 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0073 0.1752
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0055 0.0499
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0625
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0042 0.0118
Schistosoma mansoni neuropeptide receptor 0.001 0.0022 0.0022
Trypanosoma cruzi Heat shock protein 83, putative 0.0014 0.0047 0.1091
Schistosoma mansoni chromobox protein 0.0031 0.0138 0.0138
Echinococcus granulosus lipoxygenase domain containing protein 0.0304 0.1644 0.1644
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0415 0.2257 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0035 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0063 0.0209
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0022 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0035 0.0182
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.001 0.0021 0.0025
Echinococcus multilocularis casein kinase I delta 0.0041 0.0192 0.0192
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0022 0.0022
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.013
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0055 0.0288
Schistosoma mansoni smad1 5 8 and 0.001 0.0021 0.0021
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.138 0.758 0.9175
Trichomonas vaginalis CK1 family protein kinase 0.0041 0.0192 0.0785
Leishmania major cytochrome p450-like protein 0.0016 0.0055 0.1295
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0021 0.011
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0042 0.0118
Schistosoma mansoni biogenic amine receptor 0.001 0.0022 0.0022
Echinococcus granulosus histone deacetylase 6 0.0039 0.0183 0.0183
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0022 0.0022
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0035 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0035 0.0194
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0022 0.0117
Echinococcus granulosus histone deacetylase 8 0.0012 0.0032 0.0032
Schistosoma mansoni loxhd1 0.0304 0.1644 0.1644
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0007 0.0003 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0015 0.005 0.005
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0022 0.0022
Trypanosoma cruzi heat shock protein 90, putative 0.0014 0.0047 0.1091
Loa Loa (eye worm) hypothetical protein 0.0304 0.1644 0.8762
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0022 0.0022
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.001 0.0021 0.019
Onchocerca volvulus 0.001 0.0022 0.0003
Echinococcus multilocularis multidrug resistance protein 1 0.0014 0.0042 0.0042
Toxoplasma gondii histone deacetylase HDAC2 0.0012 0.0032 0.0318
Echinococcus granulosus somatostatin receptor 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0222
Echinococcus multilocularis g protein coupled receptor 0.001 0.0022 0.0022
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0027 0.0117 0.0453
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0022 0.0022
Trichomonas vaginalis CK1 family protein kinase 0.0041 0.0192 0.0785
Trypanosoma cruzi DNA repair protein, putative 0.0015 0.0048 0.1136
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0014 0.0042 0.0222
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.001 0.0021 0.0025
Echinococcus multilocularis g protein coupled receptor 0.001 0.0022 0.0022
Schistosoma mansoni endoplasmin 0.0014 0.0047 0.0047
Echinococcus multilocularis RUN 0.0304 0.1644 0.1644
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0015 0.0048 0.1136
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0015 0.0051 0.0051
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0022 0.0022
Onchocerca volvulus 0.001 0.0022 0.0003
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.001 0.0021 0.019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0015 0.005 0.005
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0043 0.0203 0.0203
Leishmania major hypothetical protein, conserved 0.0011 0.0025 0.0546
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0022 0.0022
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0022 0.0022
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0762 0.4061
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0035 0.0194
Trichomonas vaginalis ABC transporter, putative 0.0014 0.0042 0.0118
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0022 0.0022
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0035 0.0035
Plasmodium vivax perforin-like protein 3 0.0169 0.0899 0.5458
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0021 0.0021
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0022 0.0022
Echinococcus multilocularis histone deacetylase 3 0.0012 0.0032 0.0032
Echinococcus granulosus casein kinase i 0.0041 0.0192 0.0192
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0022 0.0022
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0035 0.0194
Echinococcus granulosus casein kinase I delta 0.0041 0.0192 0.0192
Trypanosoma cruzi histone deacetylase 1, putative 0.0012 0.0032 0.0719
Brugia malayi G-protein coupled receptor 0.001 0.0022 0.012
Onchocerca volvulus 0.0041 0.0192 0.0916
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0035 0.0035
Treponema pallidum recombinase A 0.0048 0.0231 0.1022
Onchocerca volvulus 0.0014 0.0042 0.0109
Brugia malayi Dopamine receptor protein 1 0.001 0.0022 0.012
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0022 0.012
Echinococcus multilocularis lipoxygenase domain containing protein 0.0304 0.1644 0.1644
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0035 0.0182
Onchocerca volvulus 0.0304 0.1644 0.8748
Schistosoma mansoni hypothetical protein 0.001 0.0022 0.0022
Echinococcus granulosus smad 0.001 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0182
Leishmania major DNA damage repair protein, putative 0.0007 0.0007 0.01
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0415 0.2257 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.001 0.0021 0.019
Treponema pallidum replicative DNA helicase (dnaB) 0.0171 0.0913 0.4043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0415 0.2257 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0043 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0055 0.1295
Trypanosoma cruzi casein kinase, delta isoform, putative 0.004 0.0188 0.4672
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) 0.0064 0.0318 0.0384
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0078 0.0399 0.0399
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0027 0.0117 0.2878
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0035 0.0068
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0331
Echinococcus multilocularis geminin 0.0146 0.0771 0.0771
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0042 0.0118
Brugia malayi Dopamine receptor protein 2 0.001 0.0022 0.012
Trypanosoma cruzi casein kinase, putative 0.0041 0.0192 0.4759
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0035 0.0162 0.0652
Plasmodium falciparum perforin-like protein 1 0.0169 0.0899 0.5458
Entamoeba histolytica hypothetical protein 0.0015 0.005 0.0085
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0012 0.0032 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0035 0.0194
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0022 0.0022
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.0027 0.0117 0.0141
Schistosoma mansoni hypothetical protein 0.001 0.0022 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0035 0.0194
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Entamoeba histolytica hypothetical protein 0.0015 0.005 0.0085
Trypanosoma cruzi casein kinase, putative 0.0041 0.0192 0.4759
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0022 0.0022
Brugia malayi Cytochrome P450 family protein 0.0036 0.0167 0.1001
Plasmodium vivax DNA repair protein REV1, putative 0.0007 0.0007 0.0024
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.001 0.0023 0.0225
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0043 0.0203 0.0203
Trypanosoma cruzi DNA damage repair protein, putative 0.0007 0.0007 0.01
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0162 0.4006
Echinococcus multilocularis netrin receptor unc 5 0.001 0.0022 0.0022
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.001 0.0021 0.019
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.001 0.0021 0.0025
Plasmodium falciparum perforin-like protein 3 0.0169 0.0899 0.5458
Plasmodium vivax multidrug resistance protein 1, putative 0.0014 0.0042 0.0237
Brugia malayi nuclear receptor NHR-88 0.0012 0.0035 0.0194
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0022 0.012
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0022 0.0022
Trypanosoma brucei casein kinase I, isoform 2 0.0041 0.0192 0.4759
Trichomonas vaginalis chromobox protein, putative 0.0019 0.007 0.0241
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0022 0.0022
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0042 0.0118
Schistosoma mansoni hypothetical protein 0.0036 0.0165 0.0165
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0035 0.0035
Loa Loa (eye worm) histone deacetylase 0.0039 0.0183 0.0971
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.001 0.0021 0.019
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0035 0.0035
Trypanosoma cruzi heat shock protein 90, putative 0.0009 0.0014 0.0268
Trypanosoma brucei heat shock protein, putative 0.0014 0.0047 0.1091
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0007 0.01
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0043 0.0203 0.2234
Brugia malayi SET domain containing protein 0.0007 0.0006 0.002
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Plasmodium falciparum perforin-like protein 5 0.0169 0.0899 0.5458
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0022 0.0117
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0024 0.0097 0.0097
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0042 0.0118
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.0027 0.0117 0.2878
Entamoeba histolytica serine/threonine protein kinase, putative 0.0042 0.0201 0.0764
Schistosoma mansoni histamine h1 receptor 0.001 0.0022 0.0022
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0042 0.0118
Echinococcus granulosus casein kinase I alpha 0.0041 0.0192 0.0192
Echinococcus granulosus neuropeptide receptor 0.001 0.0022 0.0022
Plasmodium falciparum histone deacetylase 1 0.0012 0.0032 0.0174
Trypanosoma cruzi polo-like protein kinase, putative 0.0042 0.0201 0.4989
Schistosoma mansoni histone deacetylase 4 5 0.0039 0.0183 0.0183
Trichomonas vaginalis abcb9, putative 0.0014 0.0042 0.0118
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0012 0.0031 0.0692
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0042 0.0118
Trypanosoma cruzi histone deacetylase, putative 0.0012 0.0032 0.0719
Trichomonas vaginalis histone deacetylase, putative 0.0012 0.0032 0.0071
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0035 0.0035
Onchocerca volvulus 0.001 0.0022 0.0003
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0022 0.0022
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0146 0.0771 0.0771
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0035 0.0035
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0035 0.0035
Entamoeba histolytica casein kinase, putative 0.0041 0.0192 0.0723
Schistosoma mansoni heat shock protein 0.0014 0.0047 0.0047
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0035 0.0035
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0078 0.0399 0.0399
Trypanosoma brucei heat shock protein, putative 0.0014 0.0047 0.1091
Brugia malayi hypothetical protein 0.001 0.0022 0.012
Chlamydia trachomatis replicative DNA helicase 0.0171 0.0913 1
Plasmodium falciparum multidrug resistance protein 1 0.0014 0.0042 0.0237
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0042 0.0201 0.0201
Schistosoma mansoni histone deacetylase 4 5 0.0039 0.0183 0.0183
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0022 0.0022
Echinococcus multilocularis sex peptide receptor 0.001 0.0022 0.0022
Leishmania major histone deacetylase, putative 0.0012 0.0032 0.0719
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.001 0.0021 0.019
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Schistosoma mansoni kinase 0.0022 0.0087 0.0087
Brugia malayi Histone deacetylase family protein 0.0039 0.0183 0.1096
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0022 0.0022
Schistosoma mansoni SET domain protein 0.0015 0.0051 0.0051
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0047 0.0137
Trichomonas vaginalis abcb9, putative 0.0014 0.0042 0.0118
Plasmodium vivax SET domain protein, putative 0.0043 0.0203 0.1219
Brugia malayi hypothetical protein 0.001 0.0022 0.012
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.001 0.0021 0.0025
Onchocerca volvulus Phospholipase A2 homolog 0.0346 0.1876 1
Schistosoma mansoni myosin xvIII 0.001 0.0022 0.0022
Plasmodium falciparum endoplasmin, putative 0.0009 0.0016 0.0076
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0022 0.0022
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Echinococcus granulosus g protein coupled receptor 0.001 0.0022 0.0022
Schistosoma mansoni smad1 5 8 and 0.001 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0035 0.0162 0.4006
Schistosoma mansoni Replicative DNA helicase 0.0171 0.0913 0.0913
Echinococcus multilocularis histone deacetylase 7 0.0039 0.0183 0.0183
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0022 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0073 0.1752
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Toxoplasma gondii heat shock protein 90, putative 0.0014 0.0047 0.0483
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0073 0.1752
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0035 0.0182
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.001 0.0021 0.0025
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0015 0.0048 0.0138
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.005
Echinococcus multilocularis fmrfamide receptor 0.001 0.0022 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.1744
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.001 0.0021 0.0449
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Echinococcus granulosus flap endonuclease 1 0.0012 0.0031 0.0031
Brugia malayi hypothetical protein 0.001 0.0022 0.012
Schistosoma mansoni neuropeptide receptor 0.001 0.0022 0.0022
Entamoeba histolytica histone deacetylase, putative 0.0012 0.0032 0.0005
Echinococcus multilocularis casein kinase I alpha 0.0041 0.0192 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0162 0.4006
Schistosoma mansoni cytochrome P450 0.001 0.0021 0.0021
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0035 0.0035
Leishmania major histone deacetylase, putative 0.0039 0.0183 0.4527
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.008 0.0409 0.2086
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0201 0.0201
Brugia malayi histone deacetylase 1 (HD1) 0.0012 0.0032 0.0177
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0022 0.0022
Brugia malayi isocitrate dehydrogenase 0.0007 0.0003 0.0004
Trypanosoma brucei heat shock protein, putative 0.0014 0.0047 0.1091
Loa Loa (eye worm) hypothetical protein 0.0304 0.1644 0.8762
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0042 0.0118
Brugia malayi hypothetical protein 0.0017 0.0061 0.0358
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0072 0.1744
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0201 0.0826
Echinococcus granulosus macrophage expressed protein 0.1528 0.8395 0.8395
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0014 0.0042 0.0981
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.0007 0.01
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0012
Trypanosoma brucei heat shock protein, putative 0.0014 0.0047 0.1091
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0042 0.0118
Entamoeba histolytica P-glycoprotein-2 0.0014 0.0042 0.0051
Echinococcus granulosus sex peptide receptor 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Onchocerca volvulus 0.001 0.0022 0.0003
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0042 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0035 0.0182
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.001 0.0021 0.019
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Schistosoma mansoni flap endonuclease-1 0.001 0.0025 0.0025
Schistosoma mansoni polycystin 1-related 0.0304 0.1644 0.1644
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Plasmodium vivax histone deacetylase 2, putative 0.0039 0.0183 0.1093
Trichomonas vaginalis chromobox protein, putative 0.0019 0.007 0.0241
Trichomonas vaginalis ABC transporter, putative 0.0014 0.0042 0.0118
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0042 0.0042
Giardia lamblia Histone deacetylase 0.0012 0.0032 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0043 0.0203 0.0203
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.001 0.0021 0.0025
Brugia malayi hypothetical protein 0.0011 0.0025 0.0136
Toxoplasma gondii histone deacetylase HDAC5 0.0012 0.0032 0.0323
Brugia malayi sulfakinin receptor protein 0.001 0.0022 0.012
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0167 0.0888
Brugia malayi hypothetical protein 0.001 0.0022 0.012
Trypanosoma brucei DNA polymerase IV, putative 0.0032 0.0146 0.3598
Echinococcus granulosus NADH dehydrogenase subunit 1 0.0064 0.0318 0.0318
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0026 0.0113 0.0136
Mycobacterium tuberculosis Possible formate hydrogenlyase HycD (FHL) 0.0017 0.0061 0.0074
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0035 0.0035
Trichomonas vaginalis heat shock protein, putative 0.0011 0.003 0.0065
Echinococcus granulosus chromobox protein 1 0.0031 0.0138 0.0138
Echinococcus multilocularis histone deacetylase 8 0.0012 0.0032 0.0032
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0399 1
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.0042 0.0042
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0041 0.0192 0.102
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.001 0.0021 0.0025
Trypanosoma cruzi heat shock protein 90, putative 0.0011 0.003 0.0682
Echinococcus granulosus fmrfamide receptor 0.001 0.0022 0.0022
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.001 0.0022 0.0114
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0035 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0162 0.4006
Schistosoma mansoni hypothetical protein 0.001 0.0022 0.0022
Plasmodium falciparum heat shock protein 90 0.0014 0.0047 0.0263
Echinococcus granulosus histone deacetylase 3 0.0012 0.0032 0.0032
Plasmodium vivax perforin-like protein 1 0.0169 0.0899 0.5458
Echinococcus multilocularis isocitrate dehydrogenase 0.0007 0.0003 0.0003
Brugia malayi Pre-SET motif family protein 0.0296 0.16 0.9732
Plasmodium falciparum ataxin-2 like protein, putative 0.0011 0.0025 0.0132
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0022 0.0022
Schistosoma mansoni histone deacetylase 0.0012 0.0032 0.0032
Echinococcus multilocularis allatostatin A receptor 0.001 0.0022 0.0022
Brugia malayi multidrug resistance protein 3 0.0014 0.0042 0.024
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0007 0.01
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0022 0.0022
Onchocerca volvulus 0.001 0.0022 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0022 0.0022
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0014 0.0042 0.0118
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Brugia malayi neuropeptide F receptor 0.001 0.0022 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0113 0.277
Loa Loa (eye worm) hypothetical protein 0.0043 0.0203 0.1082
Echinococcus multilocularis somatostatin receptor 0.001 0.0022 0.0022
Echinococcus multilocularis neuropeptide receptor 0.001 0.0022 0.0022
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Brugia malayi putative neuropeptide receptor 0.001 0.0022 0.012
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0042 0.0118
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0007 0.0007
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0022 0.0022
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0035 0.0035
Echinococcus granulosus geminin 0.0146 0.0771 0.0771
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0022 0.0022
Echinococcus granulosus dna polymerase eta 0.0035 0.0159 0.0159
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0022 0.0022
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0055 0.1295
Trypanosoma brucei DNA polymerase eta, putative 0.0035 0.0159 0.3937
Brugia malayi follicle stimulating hormone receptor 0.001 0.0022 0.012
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Trichomonas vaginalis CAMK family protein kinase 0.0021 0.0084 0.0305
Echinococcus granulosus orexin receptor type 2 0.001 0.0022 0.0022
Echinococcus multilocularis histone deacetylase 0.0039 0.0183 0.0183
Trypanosoma brucei histone deacetylase 1 0.0012 0.0032 0.0719
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.001 0.0021 0.0025
Brugia malayi Cytochrome P450 family protein 0.0016 0.0055 0.0316
Trichomonas vaginalis heat shock protein, putative 0.0011 0.003 0.0065
Echinococcus granulosus casein kinase I delta 0.0041 0.0192 0.0192
Toxoplasma gondii MAC/Perforin domain-containing protein 0.0169 0.0899 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0035 0.0182
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0035 0.0035
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0022 0.0022
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Onchocerca volvulus Neuropeptide F receptor homolog 0.001 0.0022 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0007 0.01
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0022 0.0022
Echinococcus multilocularis histone deacetylase 1 0.0012 0.0032 0.0032
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0022 0.0117
Brugia malayi G-protein coupled receptor 0.001 0.0022 0.012
Echinococcus multilocularis lipoxygenase domain containing protein 0.0304 0.1644 0.1644
Trypanosoma brucei PAB1-binding protein , putative 0.0011 0.0025 0.0546
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.001 0.0021 0.0025
Echinococcus multilocularis 0.001 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Schistosoma mansoni coup transcription factor 0.0012 0.0035 0.0035
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0027 0.0117 0.2878
Plasmodium vivax perforin-like protein 4 0.0169 0.0899 0.5458
Trypanosoma cruzi heat shock protein 85, putative 0.0014 0.0047 0.1091
Trichomonas vaginalis chromobox protein, putative 0.0031 0.0138 0.0543
Echinococcus granulosus histone deacetylase 7 0.0039 0.0183 0.0183
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0022 0.0022
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0035 0.0035
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0022 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0415 0.2257 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.001 0.0021 0.019
Trichomonas vaginalis histone deacetylase, putative 0.0012 0.0032 0.0071
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.001 0.0021 0.019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0022 0.0022
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0078 0.0399 0.2416
Schistosoma mansoni DNA polymerase eta 0.0035 0.0159 0.0159
Echinococcus multilocularis microtubule associated protein 2 0.0478 0.2605 0.2605
Plasmodium vivax histone deacetylase 1, putative 0.0012 0.0032 0.0174
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0201 0.0826
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0012 0.0031 0.0692
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0022 0.0022
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0159 0.0953
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0022 0.0022
Brugia malayi RE15519p 0.001 0.0022 0.012
Plasmodium falciparum casein kinase 1 0.0041 0.0192 0.1148
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0015 0.0051 0.0051
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0041 0.0192 0.4759
Trypanosoma brucei unspecified product 0.0016 0.0057 0.1345
Brugia malayi NADH dehydrogenase subunit 1, identical 0.0017 0.0061 0.0358
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.001 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0035 0.0068
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Onchocerca volvulus 0.0337 0.1826 0.9728
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0042 0.0201 0.0201
Trypanosoma brucei unspecified product 0.0016 0.0057 0.1345
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0171 0.0913 0.8407
Brugia malayi MH2 domain containing protein 0.0144 0.0762 0.4627
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0415 0.2257 1
Toxoplasma gondii casein kinase I 0.0041 0.0192 0.2104
Echinococcus granulosus g-protein coupled receptor 0.001 0.0022 0.0022
Toxoplasma gondii perforin-like protein PLP1 0.0169 0.0899 1
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0021 0.011
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0217 0.0217
Toxoplasma gondii heat shock protein HSP90 0.0014 0.0047 0.0483
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0022 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.001 0.0021 0.0025
Onchocerca volvulus Histone deacetylase 10 homolog 0.0012 0.0032 0.0053
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0415 0.2257 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0048 0.0231 0.0231
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0097 0.0117
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0182
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0012 0.0031 0.0692
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0021 0.0021
Brugia malayi Endoplasmin precursor 0.0014 0.0047 0.0267
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0022 0.012
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0011 0.003 0.003
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0035 0.0194
Onchocerca volvulus 0.001 0.0022 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0035 0.0194
Trichomonas vaginalis histone deacetylase, putative 0.0012 0.0032 0.0071
Giardia lamblia Kinase, PLK 0.0042 0.0201 0.086
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0027 0.0117 0.0453
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0041 0.0192 0.102
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.001 0.0021 0.0025
Echinococcus granulosus nuclear factor of activated T cells 5 0.0051 0.0249 0.0249
Plasmodium vivax perforin-like protein 2 0.0169 0.0899 0.5458
Plasmodium falciparum histone deacetylase, putative 0.0039 0.0183 0.1093
Schistosoma mansoni hypothetical protein 0.001 0.0022 0.0022
Brugia malayi nuclear hormone receptor 0.0012 0.0035 0.0194
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.1504 0.8262 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0035 0.0194
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.001 0.0021 0.019
Trypanosoma brucei polo-like protein kinase 0.0042 0.0201 0.4989
Onchocerca volvulus 0.001 0.0022 0.0003
Schistosoma mansoni amine GPCR 0.001 0.0022 0.0022
Leishmania major lanosterol 14-alpha-demethylase, putative 0.001 0.0021 0.0449
Echinococcus granulosus Ankyrin 0.001 0.0022 0.0022
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0012 0.0031 0.0306
Trypanosoma cruzi histone deacetylase 1, putative 0.0012 0.0032 0.0719
Trypanosoma cruzi PAB1-binding protein , putative 0.0011 0.0025 0.0546
Echinococcus granulosus chromobox protein 1 0.0031 0.0138 0.0138
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0017 0.0063 0.0219
Echinococcus multilocularis dna polymerase eta 0.0035 0.0159 0.0159
Schistosoma mansoni terminal deoxycytidyl transferase 0.0024 0.0097 0.0097
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0007 0.01
Echinococcus multilocularis heat shock protein 0.0014 0.0047 0.0047
Schistosoma mansoni multidrug resistance protein 0.0014 0.0042 0.0042
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0022 0.0022
Trypanosoma cruzi casein kinase, putative 0.0041 0.0192 0.4759
Echinococcus granulosus Polycystic kidney disease protein 0.0304 0.1644 0.1644
Trichomonas vaginalis histone deacetylase, putative 0.0012 0.0032 0.0071
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0019 0.0016
Trypanosoma cruzi DNA damage repair protein, putative 0.0007 0.0007 0.01
Loa Loa (eye worm) multidrug resistance protein 3 0.0014 0.0042 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0035 0.0194
Loa Loa (eye worm) heat shock protein 90 0.0014 0.0047 0.0245
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0159 0.3937
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0035 0.0182
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0014 0.0042 0.0118
Mycobacterium ulcerans DNA polymerase IV 0.0035 0.0162 0.1488
Echinococcus multilocularis casein kinase I alpha 0.0041 0.0192 0.0192
Entamoeba histolytica P-glycoprotein-2 0.0014 0.0042 0.0051
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0022 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0035 0.0084
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.001 0.0021 0.019
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0012
Schistosoma mansoni histone deacetylase 1 2 3 0.0012 0.0032 0.0032
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.0027 0.0117 0.0698
Schistosoma mansoni lipoxygenase 0.1819 1 1
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Onchocerca volvulus 0.001 0.0022 0.0003
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0019 0.0019
Schistosoma mansoni heat shock protein 0.0014 0.0047 0.0047
Echinococcus granulosus histone deacetylase 1 0.0012 0.0032 0.0032
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0019 0.0019
Schistosoma mansoni amine GPCR 0.001 0.0022 0.0022
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0022 0.0022
Onchocerca volvulus 0.001 0.0022 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0035 0.0035
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0022 0.0022
Onchocerca volvulus 0.001 0.0022 0.0003
Trypanosoma brucei histone deacetylase 4 0.0039 0.0183 0.4527
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.001 0.0021 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0192 0.0192
Echinococcus multilocularis histone deacetylase 6 0.0039 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0167
Trypanosoma brucei histone deacetylase, putative 0.0039 0.0183 0.4527
Giardia lamblia Flap structure-specific endonuclease 0.0012 0.0031 0.0104
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0022 0.0022
Trichomonas vaginalis histone deacetylase, putative 0.0012 0.0032 0.0071
Mycobacterium ulcerans formate hydrogenlyase HycD 0.0017 0.0061 0.0562
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0043 0.0203 0.0203
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Schistosoma mansoni histone deacetylase 0.0012 0.0032 0.0032
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0203 0.1086 1
Brugia malayi steroid hormone receptor 0.0012 0.0035 0.0194
Giardia lamblia Grp94/Hsp90 0.0011 0.003 0.0102
Echinococcus granulosus netrin receptor unc 5 0.001 0.0022 0.0022
Echinococcus granulosus Smad4 0.001 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0222
Plasmodium falciparum histone deacetylase 2 0.0039 0.0183 0.1093
Plasmodium vivax flap endonuclease 1, putative 0.0012 0.0031 0.0167
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0035 0.0182
Entamoeba histolytica P-glyco protein 6, putative 0.0014 0.0042 0.0051
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0022 0.0022
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0022 0.0117
Mycobacterium ulcerans heat shock protein 90 0.0011 0.003 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0162 0.4006
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0022 0.0022
Echinococcus multilocularis chromobox protein 1 0.0031 0.0138 0.0138
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0042 0.0434
Trypanosoma cruzi heat shock protein 85, putative 0.0014 0.0047 0.1091
Giardia lamblia Fructose-bisphosphate aldolase 0.0415 0.2257 1
Entamoeba histolytica hypothetical protein 0.0015 0.005 0.0085
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0415 0.2257 1
Schistosoma mansoni hypothetical protein 0.1528 0.8395 0.8395
Schistosoma mansoni lipoxygenase 0.1272 0.6981 0.6981
Leishmania major casein kinase, putative 0.0041 0.0192 0.4759
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0203 0.1086 0.3893
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0035 0.0035
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0012 0.0032 0.0071
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.0027 0.0117 0.0985
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0042 0.0042
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0078 0.0399 0.0399
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.0027 0.0117 0.2878
Trypanosoma cruzi histone deacetylase, putative 0.0039 0.0183 0.4527
Brugia malayi GnHR receptor homolog 0.001 0.0022 0.012
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0022 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0201 0.0826
Loa Loa (eye worm) isocitrate dehydrogenase 0.0007 0.0003 0.0015
Schistosoma mansoni Smad4 0.001 0.0021 0.0021
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0022 0.0022
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0203 0.1086 0.1314
Echinococcus granulosus heat shock protein 90 0.0011 0.003 0.003
Echinococcus multilocularis g protein coupled receptor 0.001 0.0022 0.0022
Echinococcus multilocularis fmrfamide receptor 0.001 0.0022 0.0022
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0035 0.0035
Trypanosoma brucei histone deacetylase 2 0.0012 0.0032 0.0719
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0162 0.4006
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0013 0.0041 0.0041
Schistosoma mansoni chromobox protein 0.0031 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Brugia malayi hypothetical protein 0.0304 0.1644 1
Brugia malayi hypothetical protein 0.0007 0.0004 0.001
Brugia malayi histone deacetylase 3 (HD3) 0.0012 0.0032 0.0177
Schistosoma mansoni hypothetical protein 0.0064 0.0318 0.0318
Brugia malayi larval opioid receptor 0.001 0.0022 0.012
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0022 0.0022
Trypanosoma cruzi histone deacetylase, putative 0.0039 0.0183 0.4527
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Onchocerca volvulus 0.001 0.0022 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0022 0.0022
Brugia malayi MH2 domain containing protein 0.001 0.0021 0.0112
Brugia malayi ImpB/MucB/SamB family protein 0.0024 0.0097 0.0574
Plasmodium falciparum flap endonuclease 1 0.0012 0.0031 0.0167
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0035 0.0035
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0022 0.0022
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0022 0.0022
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0035 0.0035
Entamoeba histolytica P-glycoprotein-1 0.0014 0.0042 0.0051
Onchocerca volvulus Phospholipase A2 homolog 0.012 0.0631 0.3285
Loa Loa (eye worm) histone deacetylase 11 0.0012 0.0032 0.0167
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.001 0.0021 0.019
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0022 0.0022
Schistosoma mansoni netrin receptor unc5 0.001 0.0022 0.0022
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0055 0.0288
Brugia malayi Heterochromatin protein 1 0.0031 0.0138 0.0821
Toxoplasma gondii LsmAD domain-containing protein 0.0011 0.0025 0.0242
Brugia malayi hypothetical protein 0.001 0.0022 0.012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0035 0.0035
Chlamydia trachomatis hypothetical protein 0.0169 0.0899 0.984
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0171 0.0913 0.3261
Echinococcus granulosus neuropeptide receptor 0.001 0.0022 0.0022
Schistosoma mansoni opsin-like receptor 0.001 0.0022 0.0022
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0022 0.012
Trichomonas vaginalis DNA polymerase eta, putative 0.0035 0.0162 0.0652
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0182
Onchocerca volvulus 0.001 0.0022 0.0003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0041 0.0192 0.0192
Brugia malayi heat shock protein 90 0.0014 0.0047 0.0267
Echinococcus granulosus hypothetical protein 0.001 0.0022 0.0022
Echinococcus multilocularis heat shock protein 90 0.0011 0.003 0.003
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0021 0.0021
Echinococcus multilocularis ATP binding cassette sub family B 0.0013 0.0041 0.0041
Mycobacterium ulcerans NADH dehydrogenase subunit H 0.0064 0.0318 0.2925
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.001 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Onchocerca volvulus 0.001 0.0022 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0162 0.4006
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.001 0.0022 0.0022
Brugia malayi hypothetical protein 0.001 0.0022 0.012
Schistosoma mansoni histone deacetylase hda2 0.0039 0.0183 0.0183
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0035 0.0035
Echinococcus multilocularis flap endonuclease 1 0.0012 0.0031 0.0031
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.001 0.0021 0.019
Brugia malayi Death domain containing protein 0.001 0.0022 0.0117
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0014 0.0042 0.005
Schistosoma mansoni hypothetical protein 0.0304 0.1644 0.1644
Echinococcus granulosus histone lysine methyltransferase setb 0.0043 0.0203 0.0203
Plasmodium vivax endoplasmin, putative 0.0014 0.0047 0.0263
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0182
Echinococcus multilocularis serotonin receptor 0.001 0.0022 0.0022
Echinococcus multilocularis Ankyrin 0.001 0.0022 0.0022
Echinococcus granulosus dna polymerase kappa 0.0035 0.0162 0.0162
Trypanosoma cruzi casein kinase, putative 0.0041 0.0192 0.4759
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0007 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0162 0.4006
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0042 0.0118
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.0042 0.0118
Onchocerca volvulus Serine\/threonine kinase homolog 0.0042 0.0201 0.0965
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0078 0.0399 0.2126
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0055 0.0288
Schistosoma mansoni rab6-interacting 0.0304 0.1644 0.1644
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0035 0.0035
Trypanosoma brucei heat shock protein, putative 0.0014 0.0047 0.1091
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.0027 0.0117 0.1076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0415 0.2257 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0042 0.0118
Trichomonas vaginalis histone deacetylase, putative 0.0012 0.0032 0.0071
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.001 0.0021 0.019
Brugia malayi Serotonin receptor 0.001 0.0022 0.012
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Loa Loa (eye worm) histone deacetylase 1 0.0012 0.0032 0.0167
Brugia malayi neuropeptide F receptor 0.001 0.0022 0.012
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0022 0.0022
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0022 0.0117
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0051 0.0249 0.0249
Onchocerca volvulus 0.001 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0021 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0162 0.4006
Echinococcus multilocularis multidrug resistance protein 1 0.0014 0.0042 0.0042
Echinococcus multilocularis casein kinase I delta 0.0041 0.0192 0.0192
Brugia malayi G protein-coupled receptor 0.001 0.0022 0.012
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0007 0.0003 0.0003
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.001 0.0022 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0162 0.4006
Brugia malayi Serotonin receptor 0.001 0.0022 0.012
Brugia malayi serine/threonine-protein kinase plk-2 0.0042 0.0201 0.1207
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0041 0.0192 0.102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0415 0.2257 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.001 0.0021 0.019
Trypanosoma cruzi casein kinase, putative 0.0041 0.0192 0.4759
Trypanosoma brucei heat shock protein, putative 0.0014 0.0047 0.1091
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0024 0.0097 0.0097
Trypanosoma cruzi PAB1-binding protein , putative 0.0011 0.0025 0.0546
Loa Loa (eye worm) twinkle helicase 0.0049 0.0237 0.1262
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0011 0.003 0.0682
Entamoeba histolytica P-glycoprotein-5 0.0014 0.0042 0.0051
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0042 0.0118
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0022 0.0022
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0022 0.0117
Schistosoma mansoni biogenic amine receptor 0.001 0.0022 0.0022
Onchocerca volvulus 0.004 0.0188 0.0897
Entamoeba histolytica hypothetical protein 0.0015 0.005 0.0085
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0022 0.0022
Treponema pallidum fructose-bisphosphate aldolase 0.0415 0.2257 1
Echinococcus granulosus g protein coupled receptor 0.001 0.0022 0.0022
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0007 0.0044
Echinococcus multilocularis Polycystic kidney disease protein 0.0304 0.1644 0.1644
Echinococcus granulosus neuropeptide s receptor 0.001 0.0022 0.0022
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0035 0.0035
Brugia malayi MH2 domain containing protein 0.001 0.0021 0.0112
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0012
Brugia malayi AKH receptor 0.001 0.0022 0.012
Leishmania major DNA polymerase kappa, putative 0.0007 0.0007 0.01
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0035 0.0194
Echinococcus granulosus RUN 0.0304 0.1644 0.1644
Brugia malayi chromobox protein homolog 3 0.0017 0.0063 0.0365
Toxoplasma gondii histone deacetylase HDAC1 0.0039 0.0183 0.2002
Schistosoma mansoni neuropeptide receptor 0.001 0.0022 0.0022
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0296 0.16 0.8527
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0201 0.0826
Entamoeba histolytica P-glycoprotein 5, putative 0.0014 0.0042 0.0051
Mycobacterium ulcerans recombinase A 0.0048 0.0231 0.2125
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0201 0.0826
Trypanosoma cruzi histone deacetylase, putative 0.0012 0.0032 0.0719
Schistosoma mansoni hypothetical protein 0.001 0.0021 0.0021
Trichomonas vaginalis abcb9, putative 0.0014 0.0042 0.0118
Trypanosoma brucei heat shock protein 90, putative 0.0014 0.0047 0.1091
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.001 0.0021 0.0449
Echinococcus granulosus casein kinase I alpha 0.0041 0.0192 0.0192
Giardia lamblia Heat shock protein HSP 90-alpha 0.0014 0.0047 0.0174
Trichomonas vaginalis ABC transporter, putative 0.0014 0.0042 0.0118
Giardia lamblia DINP protein human, muc B family 0.0026 0.0113 0.047
Echinococcus multilocularis chromobox protein 1 0.0031 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0022 0.0022
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Brugia malayi hypothetical protein 0.0015 0.005 0.0286
Echinococcus granulosus endoplasmin 0.0011 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0114
Schistosoma mansoni protein kinase 0.0041 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Onchocerca volvulus 0.0304 0.1644 0.8748
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.001 0.0021 0.019
Echinococcus granulosus lipoxygenase domain containing protein 0.0304 0.1644 0.1644
Echinococcus multilocularis histone deacetylase 6 0.0039 0.0183 0.0183
Toxoplasma gondii histone deacetylase HDAC4 0.0012 0.0032 0.0318
Brugia malayi Melatonin receptor type 1A 0.001 0.0022 0.012
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0035 0.0194
Schistosoma mansoni amine GPCR 0.001 0.0022 0.0022
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0022 0.0117
Echinococcus multilocularis Smad4 0.001 0.0021 0.0021
Trichomonas vaginalis ABC transporter, putative 0.0014 0.0042 0.0118
Trypanosoma brucei Heat shock protein 83, putative 0.0014 0.0047 0.1091
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.001 0.0021 0.019
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0022 0.0022
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0026 0.0113 0.277
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0022 0.0117
Brugia malayi Histone deacetylase family protein 0.0039 0.0183 0.1096
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0003 0.0003
Brugia malayi hypothetical protein 0.001 0.0022 0.012
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0048 0.0231 0.2275
Loa Loa (eye worm) flap endonuclease-1 0.0012 0.0031 0.0161
Schistosoma mansoni multidrug resistance protein 0.0014 0.0042 0.0042
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0042 0.0042
Leishmania major DNA polymerase eta, putative 0.0019 0.007 0.1675
Trypanosoma cruzi heat shock protein 85, putative 0.0011 0.003 0.0682
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0022 0.0117
Trichomonas vaginalis flap endonuclease-1, putative 0.0012 0.0031 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0022 0.0022
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0007 0.01
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.001 0.0021 0.019
Plasmodium falciparum DNA repair protein REV1, putative 0.0007 0.0007 0.0024
Brugia malayi Isocitrate dehydrogenase 0.0007 0.0003 0.0004
Echinococcus granulosus serotonin receptor 0.001 0.0022 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0035 0.0162 0.4006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0182
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0399 1
Onchocerca volvulus 0.0014 0.0042 0.0108
Echinococcus multilocularis serotonin receptor 0.001 0.0022 0.0022
Echinococcus granulosus death domain containing protein 0.001 0.0022 0.0022
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0022 0.0022
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.001 0.0022 0.0022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0035 0.0035
Trypanosoma brucei heat shock protein, putative 0.0014 0.0047 0.1091
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.001 0.0021 0.0025
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0625
Onchocerca volvulus 0.001 0.0022 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0063 0.0209
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Loa Loa (eye worm) endoplasmin 0.0014 0.0047 0.0245
Trichomonas vaginalis CAMK family protein kinase 0.0021 0.0084 0.0305
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0007 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0162 0.4006
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0762 0.4061
Brugia malayi ecdysteroid receptor 0.0012 0.0035 0.0194
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0024 0.0097 0.0097
Brugia malayi hypothetical protein 0.001 0.0022 0.012
Loa Loa (eye worm) hypothetical protein 0.0346 0.1876 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.001 0.0021 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0162 0.4006
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0014 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Toxoplasma gondii cytochrome p450 superfamily protein 0.001 0.0021 0.0199
Giardia lamblia Kinase, CK1 Casein kinase 0.0041 0.0192 0.082
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.001 0.0021 0.0025
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.001 0.0021 0.0449
Schistosoma mansoni neuropeptide receptor 0.001 0.0022 0.0022
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0014 0.0042 0.0434
Echinococcus granulosus allatostatin A receptor 0.001 0.0022 0.0022
Trichomonas vaginalis taga, putative 0.0014 0.0042 0.0118
Brugia malayi cytochrome P450 0.001 0.0021 0.0112
Leishmania major heat shock protein 83-1 0.0014 0.0047 0.1091
Giardia lamblia Heat shock protein HSP 90-alpha 0.0011 0.003 0.0102
Schistosoma mansoni transcription factor LCR-F1 0.0015 0.005 0.005
Schistosoma mansoni ankyrin 23/unc44 0.001 0.0022 0.0022
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0027 0.0117 0.2878
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0221
Loa Loa (eye worm) hypothetical protein 0.012 0.0631 0.3362
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0012
Brugia malayi Cytochrome P450 family protein 0.001 0.0021 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Echinococcus multilocularis orexin receptor type 2 0.001 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0035 0.0159 0.0846
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit H 0.0064 0.0318 0.3259
Loa Loa (eye worm) hypothetical protein 0.0013 0.0041 0.0218
Onchocerca volvulus 0.0017 0.0061 0.0213
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0014 0.0042 0.0042
Echinococcus granulosus histone deacetylase 6 0.0039 0.0183 0.0183
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0022 0.0022
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0035 0.0068
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0022 0.0022
Echinococcus multilocularis casein kinase i 0.0041 0.0192 0.0192
Onchocerca volvulus 0.001 0.0022 0.0003
Schistosoma mansoni smad1 5 8 and 0.001 0.0021 0.0021
Entamoeba histolytica P-glycoprotein-2, putative 0.0014 0.0042 0.0051
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0022 0.012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0007 0.0003 0.0003
Plasmodium vivax multidomain scavenger receptor, putative 0.0304 0.1644 1
Plasmodium falciparum perforin-like protein 2 0.0169 0.0899 0.5458
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.0027 0.0117 0.0623
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.0027 0.0117 0.0117
Trypanosoma brucei heat shock protein 90, putative 0.0014 0.0047 0.1091
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0021 0.0021
Onchocerca volvulus 0.001 0.0022 0.0003
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0171 0.0913 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.001 0.0022 0.0022
Loa Loa (eye worm) histone deacetylase 3 0.0012 0.0032 0.0167
Trypanosoma cruzi DNA polymerase kappa, putative 0.0035 0.0162 0.4006
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0022 0.0022
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0055 0.1295
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.1819 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0014 0.0042 0.0118
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0007 0.0003 0.0003
Plasmodium vivax histone deacetylase, putative 0.0012 0.0032 0.0174
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0022 0.0022
Loa Loa (eye worm) Smad1 0.001 0.0021 0.011
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0022 0.0022
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0035 0.0035
Brugia malayi MH1 domain containing protein 0.001 0.0021 0.0112
Trypanosoma cruzi histone deacetylase, putative 0.0039 0.0183 0.4527
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.001 0.0021 0.0025
Onchocerca volvulus 0.0012 0.0035 0.0068
Leishmania major DNA polymerase eta, putative 0.0035 0.0159 0.3937
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0035 0.0194
Onchocerca volvulus 0.0048 0.0231 0.1129
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0022 0.0022
Brugia malayi NADH dehydrogenase subunit 1 0.0017 0.0061 0.0358
Brugia malayi Protein kinase domain containing protein 0.0011 0.0025 0.0138
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0014 0.0042 0.0042
Mycobacterium ulcerans hypothetical protein 0.0007 0.0007 0.0063
Brugia malayi hypothetical protein 0.001 0.0022 0.012
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0022 0.0022
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0022 0.0022
Brugia malayi MH1 domain containing protein 0.001 0.0021 0.0112
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.0027 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.001 0.0022 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0201 0.0826
Trichomonas vaginalis set domain proteins, putative 0.0337 0.1826 0.8075
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0011 0.003 0.0034
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.007 0.1675
Plasmodium vivax ataxin-2 like protein, putative 0.0011 0.0025 0.0132
Plasmodium vivax perforin-like protein 5 0.0169 0.0899 0.5458
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.001 0.0021 0.019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0182
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0078 0.0399 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0014 0.0042 0.0118
Brugia malayi histone deacetylase 11 0.0012 0.0032 0.0177
Entamoeba histolytica heat shock protein 90, putative 0.0014 0.0047 0.0071
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0383
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0117
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0003 0.0003
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0048 0.0231 0.0768
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.007 0.0741
Brugia malayi Uncoordinated protein 44 0.001 0.0022 0.0117
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0201 0.0826
Plasmodium vivax histone deacetylase, putative 0.0039 0.0183 0.1093
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0019 0.0019
Treponema pallidum heat shock protein 90 0.0011 0.003 0.0132
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.001 0.0021 0.019
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0042 0.0201 0.4989
Brugia malayi Histone deacetylase 1 0.0012 0.0032 0.0177
Brugia malayi ORL1-like opioid receptor 0.001 0.0022 0.012
Echinococcus multilocularis neuropeptide receptor 0.001 0.0022 0.0022
Schistosoma mansoni smdr2 0.0014 0.0042 0.0042
Echinococcus granulosus heat shock protein 90 0.0014 0.0047 0.0047

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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