Detailed information for compound 157308

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 421.492 | Formula: C23H27N5O3
  • H donors: 1 H acceptors: 4 LogP: 2.77 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC1C(=O)c2nc([nH]c2N(C1=O)C)CCCN1N=C(CCC1=O)c1ccccc1
  • InChi: 1S/C23H27N5O3/c1-3-8-16-21(30)20-22(27(2)23(16)31)25-18(24-20)11-7-14-28-19(29)13-12-17(26-28)15-9-5-4-6-10-15/h4-6,9-10,16H,3,7-8,11-14H2,1-2H3,(H,24,25)
  • InChiKey: XEMFQUWAERJFSV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis protein arginine methyltransferase 0.0189 0.0172 0.0214
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0102 0.008 0.008
Toxoplasma gondii F5/8 type C domain-containing protein 0.0053 0.0028 0.057
Entamoeba histolytica protein kinase, putative 0.0043 0.0017 0.0187
Loa Loa (eye worm) hypothetical protein 0.004 0.0014 0.0011
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.189 0.197 0.3223
Brugia malayi hypothetical protein 0.0036 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.9483 1 1
Onchocerca volvulus 0.0086 0.0062 0.1081
Echinococcus multilocularis transmembrane protease serine 3 0.004 0.0014 0.0017
Brugia malayi CUB domain containing protein 0.0035 0.0009 0.0006
Onchocerca volvulus 0.0035 0.0009 0.0102
Echinococcus granulosus c4b binding protein beta chain 0.0039 0.0013 0.0013
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0102 0.0079 0.1638
Onchocerca volvulus 0.004 0.0014 0.0194
Brugia malayi hypothetical protein 0.0035 0.0009 0.0006
Onchocerca volvulus 0.0039 0.0013 0.018
Onchocerca volvulus 0.0035 0.0009 0.0102
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0102 0.008 0.1856
Schistosoma mansoni growth factor receptor-bound protein 0.0271 0.0258 0.0258
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0418 0.0413 0.0413
Brugia malayi Protein kinase domain containing protein 0.0053 0.0028 0.0025
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0035 0.0009 0.0009
Onchocerca volvulus 0.0036 0.001 0.0121
Schistosoma mansoni hypothetical protein 0.0035 0.0009 0.0009
Plasmodium falciparum subtilisin-like protease 2 0.0418 0.0413 1
Entamoeba histolytica SWIRM domain protein 0.0042 0.0016 0.018
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0107 0.0084 0.0132
Brugia malayi GCC2 and GCC3 family protein 0.0059 0.0034 0.0031
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2307 0.2411 0.2411
Leishmania major subtilisin-like serine peptidase 0.0418 0.0413 0.5836
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0102 0.008 0.008
Entamoeba histolytica protein kinase, putative 0.0032 0.0005 0.002
Trichomonas vaginalis conserved hypothetical protein 0.189 0.197 0.3223
Onchocerca volvulus 0.0544 0.0547 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.001
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0217 0.0201 0.0198
Plasmodium falciparum plasmepsin IX 0.0036 0.001 0.0151
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2307 0.2411 0.3947
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0418 0.0413 1
Echinococcus granulosus transmembrane protease serine 3 0.004 0.0014 0.0014
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0102 0.008 0.01
Loa Loa (eye worm) TK/ALK protein kinase 0.01 0.0077 0.0074
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Onchocerca volvulus 0.0063 0.0038 0.0641
Loa Loa (eye worm) subtilase 0.0418 0.0413 0.041
Echinococcus granulosus Mastin 0.004 0.0014 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0102 0.0079 0.1845
Schistosoma mansoni hypothetical protein 0.004 0.0014 0.0014
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.189 0.197 0.3223
Schistosoma mansoni c4b-binding protein beta chain 0.0039 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0126 0.0105 0.0101
Loa Loa (eye worm) hypothetical protein 0.0102 0.0079 0.0076
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.001
Plasmodium vivax aspartyl protease, putative 0.0036 0.001 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Plasmodium falciparum plasmepsin VII 0.0036 0.001 0.0151
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0036 0.001 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.189 0.197 0.3223
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0418 0.0413 1
Plasmodium falciparum cysteine repeat modular protein 1 0.009 0.0067 0.1549
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0418 0.0413 0.0516
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.008 0.0125
Echinococcus granulosus Furin 1 0.2307 0.2411 0.2411
Loa Loa (eye worm) DPY-31 protein 0.0035 0.0009 0.0006
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0014 0.0014
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0042 0.0016 0.002
Leishmania major arginine N-methyltransferase, type I 0.0107 0.0084 0.1147
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0035 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0009 0.0006
Echinococcus multilocularis serine:threonine protein kinase N2 0.0095 0.0072 0.009
Toxoplasma gondii kringle domain-containing protein 0.009 0.0067 0.1496
Loa Loa (eye worm) chitinase I 0.0073 0.0048 0.0045
Trichomonas vaginalis hypothetical protein 0.0053 0.0028 0.004
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0189 0.0172 0.0172
Echinococcus granulosus CUB 0.0035 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0398 0.0392 0.0392
Echinococcus multilocularis c4b binding protein beta chain 0.0039 0.0013 0.0016
Echinococcus multilocularis 0.7593 0.8002 1
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0107 0.0084 0.1147
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0017 0.0021
Onchocerca volvulus Putative endochitinase 0.0073 0.0048 0.0829
Loa Loa (eye worm) sirtuin 4 0.0102 0.008 0.0076
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0102 0.0079 0.1638
Loa Loa (eye worm) hypothetical protein 0.0296 0.0284 0.0281
Plasmodium falciparum protoporphyrinogen oxidase 0.0102 0.0079 0.1845
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0059 0.0034 0.0031
Onchocerca volvulus 0.0053 0.0028 0.0452
Echinococcus multilocularis chromatin regulatory protein sir2 0.0694 0.0705 0.0881
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Loa Loa (eye worm) aspartyl protease 6 0.0036 0.001 0.0007
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0453 0.045 0.6009
Toxoplasma gondii histone deacetylase SIR2 0.0102 0.008 0.1792
Onchocerca volvulus 0.0039 0.0013 0.018
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0103 0.008 0.0077
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0004 0.0005
Onchocerca volvulus 0.004 0.0014 0.0194
Brugia malayi amine oxidase, flavin-containing family protein 0.0144 0.0124 0.0121
Brugia malayi Angiotensin-converting enzyme family protein 0.1917 0.1998 0.1996
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0107 0.0084 0.0267
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0014 0.0014
Brugia malayi CUB domain containing protein 0.0035 0.0009 0.0006
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0053 0.0028 0.0035
Schistosoma mansoni chromatin regulatory protein sir2 0.0694 0.0705 0.0705
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5798 0.6103 0.7627
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0001 0.0001
Echinococcus multilocularis Tolloid protein 1 0.0062 0.0037 0.0046
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0003 0.0003
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0126 0.0105 0.0105
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.008 0.0125
Echinococcus multilocularis cubilin 0.0035 0.0009 0.0011
Echinococcus multilocularis discoidin domain containing receptor 2 0.0053 0.0028 0.0035
Toxoplasma gondii AGC kinase 0.0041 0.0015 0.0258
Plasmodium falciparum plasmepsin VI 0.0036 0.001 0.0151
Onchocerca volvulus 0.0039 0.0013 0.018
Toxoplasma gondii subtilisin SUB7 0.0418 0.0413 0.9655
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0014 0.0014
Echinococcus granulosus epidermal growth factor receptor 0.0746 0.0761 0.0761
Schistosoma mansoni amine oxidase 0.0102 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0035 0.0009 0.0006
Brugia malayi transcriptional regulator, Sir2 family protein 0.0102 0.008 0.0076
Toxoplasma gondii rhoptry neck protein RON1 0.0039 0.0013 0.0222
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0694 0.0705 0.115
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0189 0.0172 0.4101
Brugia malayi Kringle domain containing protein 0.009 0.0067 0.0064
Loa Loa (eye worm) hypothetical protein 0.0034 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0043 0.0017 0.0014
Echinococcus granulosus serine:threonine protein kinase N2 0.0075 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0062 0.0037 0.0034
Echinococcus multilocularis cubilin 0.0035 0.0009 0.0011
Brugia malayi NAD-dependent deacetylase SIRT1 0.0102 0.008 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0003 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Echinococcus granulosus enteropeptidase 0.004 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0189 0.0172 0.0275
Brugia malayi hypothetical protein 0.0039 0.0013 0.001
Plasmodium falciparum LCCL domain-containing protein 0.0053 0.0028 0.0591
Onchocerca volvulus 0.0035 0.0009 0.0102
Loa Loa (eye worm) trypsin family protein 0.004 0.0014 0.0011
Brugia malayi CUB domain containing protein 0.0035 0.0009 0.0006
Plasmodium vivax plasmepsin IV, putative 0.0036 0.001 0.0151
Plasmodium vivax subtilisin-like protease 1 0.0418 0.0413 1
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0418 0.0413 0.0413
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.003 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Plasmodium falciparum plasmepsin II 0.0036 0.001 0.0151
Echinococcus granulosus protein kinase c epsilon type 0.0103 0.008 0.008
Entamoeba histolytica protein kinase, putative 0.0043 0.0017 0.0187
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0418 0.0413 1
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0189 0.0172 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.0418 0.0413 0.0671
Loa Loa (eye worm) proprotein convertase 2 0.2307 0.2411 0.2409
Toxoplasma gondii aspartyl protease ASP3 0.0036 0.001 0.0146
Plasmodium vivax hypothetical protein, conserved 0.0102 0.008 0.1856
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1917 0.1998 0.1996
Plasmodium vivax plasmepsin V, putative 0.0409 0.0404 0.9776
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.008 0.008
Echinococcus granulosus methyltransferase protein 5 0.0107 0.0084 0.0084
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0502 0.0502 0.0499
Schistosoma mansoni hypothetical protein 0.004 0.0014 0.0014
Echinococcus granulosus discoidin domain containing receptor 2 0.0053 0.0028 0.0028
Echinococcus granulosus C type lectin domian containing protein 0.0039 0.0013 0.0013
Loa Loa (eye worm) AGC/AKT protein kinase 0.0043 0.0017 0.0013
Brugia malayi SWIRM domain containing protein 0.0544 0.0547 0.0544
Plasmodium falciparum plasmepsin V 0.0409 0.0404 0.9776
Plasmodium vivax LCCL domain-containing protein 0.0053 0.0028 0.0591
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Onchocerca volvulus 0.004 0.0014 0.0194
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0189 0.0172 0.0172
Giardia lamblia Hypothetical protein 0.0694 0.0705 0.1889
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0107 0.0084 0.0081
Loa Loa (eye worm) hypothetical protein 0.004 0.0014 0.0011
Toxoplasma gondii F5/8 type C domain-containing protein 0.0053 0.0028 0.057
Loa Loa (eye worm) hypothetical protein 0.004 0.0014 0.0011
Toxoplasma gondii rhoptry neck protein RON9 0.0039 0.0013 0.0222
Loa Loa (eye worm) hypothetical protein 0.0035 0.0009 0.0006
Echinococcus multilocularis membrane bound transcription factor site 1 0.0418 0.0413 0.0516
Loa Loa (eye worm) hypothetical protein 0.01 0.0077 0.0074
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.004 0.0014 0.0011
Brugia malayi hypothetical protein 0.0039 0.0013 0.001
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0694 0.0705 0.0705
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0004 0.0004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.001 0.001
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0694 0.0705 1
Giardia lamblia Furin precursor putative serine protease 0.189 0.197 0.5357
Entamoeba histolytica SWIRM domain protein 0.0042 0.0016 0.018
Loa Loa (eye worm) endoprotease bli-4 0.9483 1 1
Echinococcus granulosus neuroendocrine convertase 2 0.5992 0.6308 0.6308
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1283 0.1328 0.1328
Echinococcus granulosus MAM 0.01 0.0077 0.0077
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0165 0.0146 0.0146
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.008 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.189 0.197 0.3223
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0189 0.0172 0.0214
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0102 0.008 0.1083
Entamoeba histolytica PH domain containing protein kinase, putative 0.0077 0.0053 0.0707
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0017 0.0021
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0102 0.0079 0.1333
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0694 0.0705 0.115
Trichomonas vaginalis conserved hypothetical protein 0.189 0.197 0.3223
Trichomonas vaginalis conserved hypothetical protein 0.0418 0.0413 0.0671
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0017 0.0021
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.001 0.001
Toxoplasma gondii subtilisin SUB9 0.0418 0.0413 0.9655
Brugia malayi aspartic protease BmAsp-2, identical 0.0036 0.001 0.0007
Brugia malayi Lectin C-type domain containing protein 0.0035 0.0009 0.0006
Toxoplasma gondii subtilisin SUB5 0.0418 0.0413 0.9655
Echinococcus multilocularis adam 0.0057 0.0031 0.0039
Loa Loa (eye worm) hypothetical protein 0.0035 0.0009 0.0006
Onchocerca volvulus 0.009 0.0067 0.1174
Plasmodium falciparum plasmepsin I 0.0036 0.001 0.0151
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Schistosoma mansoni hypothetical protein 0.01 0.0077 0.0077
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0694 0.0705 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2307 0.2411 0.3947
Schistosoma mansoni protein arginine n-methyltransferase 0.0107 0.0084 0.0084
Plasmodium falciparum subtilisin-like protease 3 0.0418 0.0413 1
Entamoeba histolytica chitinase, putative 0.0073 0.0048 0.0637
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0043 0.0017 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.189 0.197 0.3223
Echinococcus granulosus discoidin domain containing receptor 2 0.0053 0.0028 0.0028
Brugia malayi protein kinase C II. 0.0103 0.008 0.0077
Trypanosoma cruzi UDP-galactopyranose mutase 0.0102 0.0079 0.019
Onchocerca volvulus 0.0221 0.0205 0.3712
Echinococcus multilocularis fibrillin 1 0.0029 0.0002 0.0002
Echinococcus granulosus dnaJ subfamily B 0.0398 0.0392 0.0392
Brugia malayi Furin-like cysteine rich region family protein 0.0746 0.0761 0.0758
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Toxoplasma gondii histone deacetylase SIR2-like 0.0102 0.008 0.1792
Brugia malayi hypothetical protein 0.0102 0.0079 0.0076
Loa Loa (eye worm) hypothetical protein 0.0035 0.0009 0.0006
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0102 0.0079 0.0079
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0036 0.001 0.001
Schistosoma mansoni hypothetical protein 0.01 0.0077 0.0077
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.004 0.0014 0.0014
Echinococcus multilocularis enteropeptidase 0.004 0.0014 0.0017
Onchocerca volvulus Putative endochitinase 0.0073 0.0048 0.0829
Onchocerca volvulus Putative endochitinase 0.0073 0.0048 0.0829
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0035 0.0009 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0009 0.0008
Brugia malayi proprotein convertase 2 0.5992 0.6308 0.6307
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.189 0.197 0.3223
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.003 0.0004 0.0004
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0102 0.008 0.0197
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0035 0.0009 0.0006
Echinococcus granulosus chromatin regulatory protein sir2 0.0694 0.0705 0.0705
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0102 0.008 0.1083
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0247 0.0233 0.0291
Loa Loa (eye worm) hypothetical protein 0.004 0.0014 0.0011
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0102 0.008 0.008
Brugia malayi CUB domain containing protein 0.0035 0.0009 0.0006
Onchocerca volvulus 0.0039 0.0013 0.018
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.004 0.0014 0.0011
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0004 0.0005
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.008 0.0125
Loa Loa (eye worm) transcriptional regulator 0.0694 0.0705 0.0702
Schistosoma mansoni protein kinase 0.0247 0.0233 0.0233
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0107 0.0084 0.1147
Trypanosoma brucei rac serine-threonine kinase, putative 0.0043 0.0017 0.0187
Loa Loa (eye worm) TK/EGFR protein kinase 0.0746 0.0761 0.0758
Leishmania major chitinase 0.0073 0.0048 0.0637
Brugia malayi astacin protease protein 30 0.0035 0.0009 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2307 0.2411 0.3947
Toxoplasma gondii subtilisin SUB12 0.0431 0.0428 1
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0107 0.0084 0.1898
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0296 0.0284 0.3404
Brugia malayi hypothetical protein 0.0296 0.0284 0.0281
Loa Loa (eye worm) hypothetical protein 0.01 0.0077 0.0074
Leishmania major sir2-family protein-like protein 0.0102 0.008 0.1083
Entamoeba histolytica hypothetical protein 0.0042 0.0016 0.018
Loa Loa (eye worm) hypothetical protein 0.0544 0.0547 0.0544
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Echinococcus multilocularis protein kinase c epsilon type 0.0103 0.008 0.01
Trichomonas vaginalis conserved hypothetical protein 0.189 0.197 0.3223
Onchocerca volvulus 0.0209 0.0193 0.3486
Onchocerca volvulus 0.01 0.0077 0.1358
Toxoplasma gondii histone lysine-specific demethylase 0.0102 0.0079 0.1782
Trichomonas vaginalis conserved hypothetical protein 0.189 0.197 0.3223
Plasmodium vivax aspartyl proteinase, putative 0.0036 0.001 0.0151
Echinococcus multilocularis MAM 0.01 0.0077 0.0096
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0418 0.0413 0.0413
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Mycobacterium tuberculosis Conserved hypothetical protein 0.0102 0.0079 0.1333
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0021
Entamoeba histolytica hypothetical protein, conserved 0.0102 0.008 0.1083
Toxoplasma gondii subtilisin SUB2 0.0418 0.0413 0.9655
Leishmania major arginine N-methyltransferase-like protein 0.0189 0.0172 0.2393
Onchocerca volvulus 0.004 0.0014 0.0194
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0036 0.001 0.0007
Plasmodium vivax apical sushi protein, putative 0.0039 0.0013 0.023
Echinococcus granulosus protein arginine N methyltransferase 7 0.0107 0.0084 0.0084
Echinococcus multilocularis growth factor receptor bound protein 2 0.0271 0.0258 0.0323
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0102 0.008 0.1345
Mycobacterium ulcerans NAD-dependent deacetylase 0.0102 0.008 0.1649
Onchocerca volvulus 0.0418 0.0413 0.7539
Trypanosoma brucei SIR2-like protein 4, putative 0.0102 0.008 0.1083
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0694 0.0705 1
Mycobacterium ulcerans oxidoreductase 0.0102 0.0079 0.1638
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0053 0.0028 0.004
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0453 0.045 0.6009
Giardia lamblia High cysteine membrane protein Group 2 0.3491 0.3663 1
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0014 0.0014
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0036 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0296 0.0284 0.4
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0014 0.0014
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0189 0.0172 0.4101
Brugia malayi Muscle positioning protein 4 0.004 0.0014 0.0011
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0102 0.008 0.01
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0043 0.0017 0.0017
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0418 0.0413 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0247 0.0233 0.0233
Echinococcus granulosus glycoprotein Antigen 5 0.004 0.0014 0.0014
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0053 0.0028 0.004
Brugia malayi Trypsin family protein 0.004 0.0014 0.0011
Schistosoma mansoni hypothetical protein 0.0035 0.0009 0.0009
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0107 0.0084 0.0267
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.008 0.0125
Echinococcus granulosus cubilin 0.0035 0.0009 0.0009
Schistosoma mansoni chromatin regulatory protein sir2 0.0102 0.008 0.008
Plasmodium vivax LCCL domain-containing protein 0.0053 0.0028 0.0591
Loa Loa (eye worm) hypothetical protein 0.0102 0.008 0.0076
Loa Loa (eye worm) hypothetical protein 0.0035 0.0009 0.0006
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0062 0.0037 0.0037
Plasmodium vivax aspartyl protease, putative 0.0036 0.001 0.0151
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.001
Echinococcus multilocularis CUB 0.0035 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.001
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.004 0.0014 0.0014
Plasmodium falciparum subtilisin-like protease 1 0.0418 0.0413 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0014 0.0014
Brugia malayi Protein kinase domain containing protein 0.0043 0.0017 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0001 0.0001
Brugia malayi Nematode astacin protease protein 30 0.0035 0.0009 0.0006
Brugia malayi p70 ribosomal S6 kinase beta 0.0041 0.0015 0.0011
Plasmodium vivax cysteine repeat modular protein 1, putative 0.009 0.0067 0.1549
Plasmodium vivax subtilisin-like serine protease, putative 0.0418 0.0413 1
Brugia malayi Protein kinase domain containing protein 0.009 0.0067 0.0064
Brugia malayi Sushi domain 0.0039 0.0013 0.001
Toxoplasma gondii aspartyl protease 0.0036 0.001 0.0146
Schistosoma mansoni SWI/SNF complex-related 0.0042 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0502 0.0502 0.0499
Echinococcus multilocularis tissue type plasminogen activator 0.009 0.0067 0.0084
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.001 0.001
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0028 0.0001 0.0002
Brugia malayi Calcium binding EGF domain containing protein 0.0055 0.003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0144 0.0124 0.0121
Echinococcus multilocularis discoidin domain containing receptor 2 0.0053 0.0028 0.0035
Mycobacterium ulcerans monoamine oxidase 0.0102 0.0079 0.1638
Schistosoma mansoni site-1 peptidase (S08 family) 0.0418 0.0413 0.0413
Loa Loa (eye worm) hypothetical protein 0.0053 0.0028 0.0025
Schistosoma mansoni amine oxidase 0.0102 0.0079 0.0079
Brugia malayi hypothetical protein 0.0039 0.0013 0.001
Plasmodium falciparum plasmepsin VIII, putative 0.0036 0.001 0.0151
Mycobacterium tuberculosis Possible chitinase 0.0062 0.0037 0.0237
Loa Loa (eye worm) hypothetical protein 0.0158 0.0139 0.0136
Mycobacterium ulcerans chitinase/cellulase 0.0062 0.0037 0.058
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0014 0.0014
Echinococcus granulosus Tolloid protein 1 0.0062 0.0037 0.0037
Echinococcus multilocularis protein will die slowly 0.0209 0.0193 0.0241
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Brugia malayi celfurPC protein 0.7593 0.8002 0.8001
Loa Loa (eye worm) transcriptional regulator 0.0102 0.008 0.0076
Brugia malayi neuroendocrine convertase 1 precursor 0.5992 0.6308 0.6307
Toxoplasma gondii aspartyl protease ASP1 0.0036 0.001 0.0146
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0296 0.0284 0.4
Brugia malayi hypothetical protein 0.004 0.0014 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0418 0.0413 0.0671
Schistosoma mansoni discoidin domain receptor 0.0053 0.0028 0.0028
Plasmodium falciparum plasmepsin III 0.0036 0.001 0.0151
Schistosoma mansoni hypothetical protein 0.189 0.197 0.197
Schistosoma mansoni chromatin regulatory protein sir2 0.0694 0.0705 0.0705
Toxoplasma gondii aspartyl protease ASP5 0.0373 0.0365 0.8531
Mycobacterium ulcerans chitinase/cellulase 0.0062 0.0037 0.058
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0296 0.0284 0.4
Schistosoma mansoni btb and poz domain-containing protein 0.0053 0.0028 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.189 0.197 0.3223
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0102 0.008 0.1083
Schistosoma mansoni cathepsin D (A01 family) 0.0036 0.001 0.001
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0035 0.0009 0.0006
Brugia malayi Endochitinase 0.0073 0.0048 0.0045
Schistosoma mansoni growth factor receptor-bound protein 0.0271 0.0258 0.0258
Brugia malayi Trypsin-like protease protein 5 0.004 0.0014 0.0011
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0502 0.0502 0.0627
Echinococcus granulosus adam 0.0057 0.0031 0.0031
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0039 0.0013 0.001
Mycobacterium tuberculosis Possible oxidoreductase 0.0102 0.0079 0.1333
Brugia malayi Eukaryotic aspartyl protease family protein 0.0036 0.001 0.0007
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0418 0.0413 1
Schistosoma mansoni tyrosine kinase 0.0746 0.0761 0.0761
Loa Loa (eye worm) hypothetical protein 0.0126 0.0105 0.0101
Brugia malayi CUB domain containing protein 0.0039 0.0013 0.0009
Echinococcus granulosus furin 0.9483 1 1
Echinococcus granulosus tissue type plasminogen activator 0.009 0.0067 0.0067
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.003 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0035 0.0009 0.0009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.001 0.001
Loa Loa (eye worm) cuticular endochitinase 0.0073 0.0048 0.0045
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.001
Echinococcus granulosus lysine specific histone demethylase 1A 0.0502 0.0502 0.0502
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0014 0.0014
Schistosoma mansoni chromatin regulatory protein sir2 0.0102 0.008 0.008
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0017 0.0021
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.008 0.0125
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0107 0.0084 0.0267
Onchocerca volvulus Putative endochitinase 0.0073 0.0048 0.0829
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0107 0.0084 0.0105
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0017 0.0021
Chlamydia trachomatis protoporphyrinogen oxidase 0.0102 0.0079 0.5
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.0392 0.049
Brugia malayi Subtilase family protein 0.0418 0.0413 0.041
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0004 0.0005
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0043 0.0017 0.0013
Entamoeba histolytica protein kinase, putative 0.0041 0.0015 0.0156
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0502 0.0502 0.0502
Brugia malayi Probable ATP-dependent helicase DHX35 0.0034 0.0007 0.0004
Giardia lamblia Transcriptional regulator, Sir2 family 0.0102 0.008 0.0174
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.008 0.0056 0.0056
Plasmodium vivax aspartyl protease, putative 0.0036 0.001 0.0151
Loa Loa (eye worm) hypothetical protein 0.3685 0.3868 0.3866
Loa Loa (eye worm) transcriptional regulator 0.0102 0.008 0.0076
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0233 0.0218 0.0218
Brugia malayi hypothetical protein 0.0039 0.0013 0.001
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0107 0.0084 0.1147
Loa Loa (eye worm) hypothetical protein 0.004 0.0014 0.0011
Toxoplasma gondii bicoid-interacting protein BIN3 0.0107 0.0084 0.1898
Schistosoma mansoni hypothetical protein 0.0053 0.0028 0.0028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5798 0.6103 1
Mycobacterium ulcerans Sir2-like regulatory protein 0.0102 0.008 0.1649
Brugia malayi Sex muscle abnormal protein 5 0.0271 0.0258 0.0255
Echinococcus multilocularis glycoprotein Antigen 5 0.004 0.0014 0.0017
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.9483 1 1
Echinococcus multilocularis discoidin domain receptor 0.0053 0.0028 0.0035
Echinococcus granulosus protein arginine N methyltransferase 8 0.0189 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0036 0.001 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2307 0.2411 0.3947
Leishmania major hypothetical protein, conserved 0.009 0.0067 0.0904
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.008 0.0125
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.008 0.0125
Brugia malayi endochitinase 0.0073 0.0048 0.0045
Schistosoma mansoni hypothetical protein 0.0035 0.0009 0.0009
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0102 0.008 0.0125
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0017 0.0021
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0017 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Echinococcus granulosus growth factor receptor bound protein 2 0.0271 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0035 0.0009 0.0006
Echinococcus multilocularis epidermal growth factor receptor 0.0746 0.0761 0.0951
Echinococcus granulosus protein arginine methyltransferase 0.0189 0.0172 0.0172
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0036 0.001 0.0007
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0062 0.0037 0.0034
Brugia malayi Will die slowly protein 0.0209 0.0193 0.019
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0418 0.0413 1
Brugia malayi Protein arginine N-methyltransferase 0.0107 0.0084 0.0081
Brugia malayi transcriptional regulator, Sir2 family protein 0.0102 0.008 0.0076
Loa Loa (eye worm) reprolysin 0.0043 0.0017 0.0014
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0418 0.0413 0.5422
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Loa Loa (eye worm) DEAH box polypeptide 35 0.0034 0.0007 0.0004
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0694 0.0705 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.001 0.001
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0107 0.0084 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0016 0.0021
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0271 0.0258 0.0255
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0418 0.0413 1
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0107 0.0084 0.0267
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0035 0.0009 0.0006
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.001 0.001
Plasmodium vivax subtilisin-like protease 2, putative 0.0418 0.0413 1
Plasmodium falciparum apical sushi protein 0.0039 0.0013 0.023
Schistosoma mansoni protein kinase 0.0247 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0102 0.0079 0.0076
Leishmania major UDP-galactopyranose mutase 0.0102 0.0079 0.1077
Schistosoma mansoni hypothetical protein 0.0035 0.0009 0.0009
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0035 0.0009 0.0006
Trichomonas vaginalis WD repeat domain, putative 0.0209 0.0193 0.031
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0296 0.0284 0.3404
Schistosoma mansoni septate junction protein 0.0073 0.0049 0.0049
Loa Loa (eye worm) Carm1-pending protein 0.0107 0.0084 0.0081
Echinococcus granulosus cubilin 0.0035 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0043 0.0017 0.0013
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0036 0.001 0.0146
Schistosoma mansoni dock 0.0053 0.0028 0.0028
Toxoplasma gondii PA14 domain-containing protein 0.0053 0.0028 0.057
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Schistosoma mansoni cathepsin D (A01 family) 0.0036 0.001 0.001
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0107 0.0084 0.1898
Brugia malayi hypothetical protein 0.0036 0.001 0.0007
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0418 0.0413 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0102 0.0079 0.1845
Brugia malayi hypothetical protein 0.01 0.0077 0.0074
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.001
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5798 0.6103 0.6103
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0694 0.0705 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0102 0.008 0.0197
Echinococcus multilocularis discoidin domain containing receptor 2 0.0053 0.0028 0.0035
Toxoplasma gondii subtilisin SUB1 0.0418 0.0413 0.9655
Onchocerca volvulus 0.0039 0.0013 0.018
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0057 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.001
Schistosoma mansoni chromatin regulatory protein sir2 0.0694 0.0705 0.0705
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0418 0.0413 1
Schistosoma mansoni furin-1 (S08 family) 0.4102 0.431 0.431
Schistosoma mansoni hypothetical protein 0.0107 0.0084 0.0084
Echinococcus granulosus lysine specific histone demethylase 1A 0.0102 0.0079 0.0079
Onchocerca volvulus 0.0036 0.001 0.0121
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0013
Onchocerca volvulus Putative endochitinase 0.0073 0.0048 0.0829
Trichomonas vaginalis hypothetical protein 0.189 0.197 0.3223
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0035 0.0009 0.0011
Giardia lamblia Sirtuin type 2 0.0102 0.008 0.0174
Echinococcus granulosus protein will die slowly 0.0209 0.0193 0.0193
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0043 0.0017 0.0017
Onchocerca volvulus 0.004 0.0014 0.0194
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5798 0.6103 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0076 0.0051 0.0051
Onchocerca volvulus 0.0039 0.0013 0.018
Schistosoma mansoni chromatin regulatory protein sir2 0.0102 0.008 0.008
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0053 0.0028 0.0035
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0053 0.0028 0.004
Loa Loa (eye worm) hypothetical protein 0.01 0.0077 0.0074
Toxoplasma gondii SWIRM domain-containing protein 0.0042 0.0016 0.0298
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0189 0.0172 0.0275
Mycobacterium ulcerans dehydrogenase 0.0102 0.0079 0.1638
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0042 0.0016 0.0016
Leishmania major silent information regulator 2, putative 0.0694 0.0705 1
Trichomonas vaginalis conserved hypothetical protein 0.189 0.197 0.3223
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0102 0.0079 0.1638
Echinococcus multilocularis neuroendocrine convertase 2 0.5992 0.6308 0.7884
Echinococcus multilocularis Furin 1 0.2307 0.2411 0.3014
Loa Loa (eye worm) hypothetical protein 0.009 0.0067 0.0064
Brugia malayi hypothetical protein 0.0039 0.0013 0.001
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0453 0.045 0.637
Toxoplasma gondii subtilisin SUB6 0.0418 0.0413 0.9655
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0035 0.0009 0.0009
Brugia malayi Nematode astacin protease protein 30 0.0035 0.0009 0.0006
Onchocerca volvulus 0.0039 0.0013 0.018
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0418 0.0413 1
Trichomonas vaginalis conserved hypothetical protein 0.0418 0.0413 0.0671
Schistosoma mansoni discoidin domain receptor 0.0053 0.0028 0.0028
Brugia malayi hypothetical protein 0.0039 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0055 0.003 0.0027
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0035 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Brugia malayi endochitinase 0.0073 0.0048 0.0045
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0217 0.0201 0.0198
Brugia malayi Trypsin family protein 0.004 0.0014 0.0011
Plasmodium vivax NAD-dependent deacetylase, putative 0.0102 0.008 0.1856
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0107 0.0084 0.0105
Schistosoma mansoni hypothetical protein 0.009 0.0067 0.0067
Loa Loa (eye worm) CUB domain-containing protein 0.0035 0.0009 0.0006
Brugia malayi hypothetical protein 0.0057 0.0031 0.0028
Loa Loa (eye worm) microfilarial chitinase 0.0062 0.0037 0.0034
Loa Loa (eye worm) TK/ROR protein kinase 0.009 0.0067 0.0064
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Loa Loa (eye worm) hypothetical protein 0.0418 0.0413 0.041
Loa Loa (eye worm) hypothetical protein 0.0039 0.0013 0.0009
Echinococcus multilocularis protoporphyrinogen oxidase 0.0102 0.0079 0.0099
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2307 0.2411 0.3947
Echinococcus granulosus Protein kinase C brain isozyme 0.0028 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2307 0.2411 0.3947
Plasmodium vivax hypothetical protein, conserved 0.0102 0.0079 0.1845
Echinococcus multilocularis C type lectin domian containing protein 0.0039 0.0013 0.0016
Toxoplasma gondii subtilisin SUB10 0.0418 0.0413 0.9655
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0102 0.0079 0.1845
Onchocerca volvulus 0.0035 0.0009 0.0102
Schistosoma mansoni protein kinase 0.0247 0.0233 0.0233
Plasmodium falciparum LCCL domain-containing protein 0.0053 0.0028 0.0591
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0102 0.008 0.1083
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0014 0.0014
Trypanosoma cruzi UDP-galactopyranose mutase 0.0102 0.0079 0.019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0102 0.0079 0.1782
Onchocerca volvulus 0.0126 0.0105 0.1861
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0102 0.0079 0.1845
Brugia malayi SWIRM domain containing protein 0.0042 0.0016 0.0013
Echinococcus granulosus discoidin domain containing receptor 2 0.0053 0.0028 0.0028
Loa Loa (eye worm) CUB domain-containing protein 0.0035 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0036 0.001 0.0007
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.004 0.0014 0.0014
Brugia malayi Pepsin A precursor 0.0036 0.001 0.0007
Echinococcus granulosus membrane bound transcription factor site 1 0.0418 0.0413 0.0413
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0102 0.008 0.01
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0694 0.0705 0.0881
Schistosoma mansoni hypothetical protein 0.0209 0.0193 0.0193
Onchocerca volvulus 0.0039 0.0013 0.018
Trichomonas vaginalis conserved hypothetical protein 0.189 0.197 0.3223
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Mycobacterium leprae Possible secreted protease 0.0418 0.0413 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0041 0.0015 0.0011
Brugia malayi Trypsin family protein 0.0126 0.0105 0.0101
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0189 0.0172 0.3959
Brugia malayi transcriptional regulator, Sir2 family protein 0.0694 0.0705 0.0702
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0043 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0053 0.0028 0.0025
Plasmodium falciparum plasmepsin IV 0.0036 0.001 0.0151
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0014 0.0014
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0102 0.0079 0.1845
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0189 0.0172 0.0275
Onchocerca volvulus 0.0039 0.0013 0.018
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0107 0.0084 0.0132
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0102 0.008 0.0174
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0036 0.001 0.001
Brugia malayi Trypsin family protein 0.004 0.0014 0.0011
Brugia malayi Kelch motif family protein 0.0035 0.0009 0.0006
Schistosoma mansoni chromatin regulatory protein sir2 0.0102 0.008 0.008
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0102 0.008 0.1856
Loa Loa (eye worm) hypothetical protein 0.0062 0.0037 0.0034
Brugia malayi pregnancy-associated plasma protein-A 0.0039 0.0013 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Echinococcus granulosus discoidin domain receptor 0.0053 0.0028 0.0028
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.004 0.0014 0.0017
Schistosoma mansoni memapsin-2 (A01 family) 0.0036 0.001 0.001
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.004 0.0014 0.0017
Plasmodium vivax aspartyl proteinase, putative 0.0036 0.001 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Trichomonas vaginalis conserved hypothetical protein 0.189 0.197 0.3223
Onchocerca volvulus 0.01 0.0077 0.1358
Toxoplasma gondii F5/8 type C domain-containing protein 0.0053 0.0028 0.057
Onchocerca volvulus 0.0039 0.0013 0.018
Brugia malayi hypothetical protein 0.0039 0.0013 0.001
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0036 0.001 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0107 0.0084 0.0084
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0014 0.0014
Trypanosoma cruzi subtilisin peptidase 0.0418 0.0413 0.5422
Trypanosoma brucei subtilisin peptidase 0.0418 0.0413 0.5836
Brugia malayi Carm1-pending protein 0.0107 0.0084 0.0081
Loa Loa (eye worm) WD40 repeat protein 0.0209 0.0193 0.019
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0017 0.0021
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0053 0.0028 0.0028
Toxoplasma gondii subtilisin SUB11 0.0418 0.0413 0.9655
Echinococcus multilocularis 0.0102 0.0079 0.0099
Onchocerca volvulus Putative cubilin 0.0055 0.003 0.0489
Brugia malayi aspartic protease BmAsp-1, identical 0.0036 0.001 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Loa Loa (eye worm) hypothetical protein 0.0036 0.001 0.0007
Toxoplasma gondii subtilisin SUB8 0.0418 0.0413 0.9655
Echinococcus multilocularis Mastin 0.004 0.0014 0.0017
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0418 0.0413 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0418 0.0413 0.0671
Toxoplasma gondii subtilisin SUB4 0.0418 0.0413 0.9655
Schistosoma mansoni site-1 peptidase (S08 family) 0.0418 0.0413 0.0413
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0418 0.0413 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Plasmodium falciparum plasmepsin X 0.0036 0.001 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0028 0.004
Brugia malayi Protein kinase domain containing protein 0.01 0.0077 0.0074
Onchocerca volvulus 0.0053 0.0028 0.0452

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.81 uM Binding affinity at adenosine A1 receptor. ChEMBL. 15139758
Ki (binding) = 0.81 uM Binding affinity at adenosine A1 receptor. ChEMBL. 15139758

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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