Detailed information for compound 157348

Basic information

Technical information
  • TDR Targets ID: 157348
  • Name: (2R)-4-(4-aminopiperidin-1-yl)-2-benzyl-N-[(2 S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy- 6-pyridin-2-ylhexan-2-yl]amino]-3-(1H-imidazo l-5-yl)-1-oxopropan-2-yl]-4-oxobutanamide
  • MW: 701.898 | Formula: C39H55N7O5
  • H donors: 6 H acceptors: 7 LogP: 3.23 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC1CCN(CC1)C(=O)C[C@H](C(=O)N[C@H](C(=O)N[C@H]([C@H]([C@H](CCc1ccccn1)O)O)CC1CCCCC1)Cc1c[nH]cn1)Cc1ccccc1
  • InChi: 1S/C39H55N7O5/c40-30-16-19-46(20-17-30)36(48)23-29(21-27-9-3-1-4-10-27)38(50)45-34(24-32-25-41-26-43-32)39(51)44-33(22-28-11-5-2-6-12-28)37(49)35(47)15-14-31-13-7-8-18-42-31/h1,3-4,7-10,13,18,25-26,28-30,33-35,37,47,49H,2,5-6,11-12,14-17,19-24,40H2,(H,41,43)(H,44,51)(H,45,50)/t29-,33+,34+,35+,37-/m1/s1
  • InChiKey: LGVOTNOMAMGKRU-XHRNTERESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R)-4-(4-amino-1-piperidyl)-2-benzyl-N-[(1S)-2-[[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-(2-pyridyl)pentyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-4-oxo-butanamide
  • (2R)-4-(4-amino-1-piperidinyl)-2-benzyl-N-[(1S)-2-[[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-(2-pyridyl)pentyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxoethyl]-4-oxobutanamide
  • (2R)-4-(4-azanylpiperidin-1-yl)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-pyridin-2-yl-hexan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxo-propan-2-yl]-4-oxo-2-(phenylmethyl)butanamide
  • (2R)-4-(4-aminopiperidino)-2-benzyl-N-[(1S)-2-[[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-(2-pyridyl)pentyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-keto-ethyl]-4-keto-butyramide
  • (2R)-4-(4-aminopiperidin-1-yl)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-pyridin-2-ylhexan-2-yl]amino]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]-4-oxo-2-(phenylmethyl)butanamide
  • (2R)-4-(4-amino-1-piperidyl)-N-[(1S)-2-[[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-(2-pyridyl)pentyl]amino]-1-(3H-imidazol-4-ylmethyl)-2-oxo-ethyl]-4-oxo-2-(phenylmethyl)butanamide
  • (2R)-4-(4-amino-1-piperidinyl)-N-[(1S)-2-[[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-(2-pyridyl)pentyl]amino]-1-(3H-imidazol-4-ylmethyl)-2-oxoethyl]-4-oxo-2-(phenylmethyl)butanamide
  • (2R)-4-(4-amino-1-piperidyl)-2-(benzyl)-N-[(1S)-2-[[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-(2-pyridyl)pentyl]amino]-1-(3H-imidazol-4-ylmethyl)-2-keto-ethyl]-4-keto-butyramide
  • (2R)-4-(4-aminopiperidin-1-yl)-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-pyridin-2-yl-hexan-2-yl]amino]-3-(3H-imidazol-4-yl)-1-oxo-propan-2-yl]-4-oxo-2-(phenylmethyl)butanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Renin Starlite/ChEMBL References
Homo sapiens renin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis aspartyl protease precursor Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum Cathepsin D precursor, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Babesia bovis eukaryotic aspartyl protease family protein Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum ko:K01379 cathepsin D [EC3.4.23.5], putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) aspartic protease BmAsp-2 Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax aspartyl proteinase, putative Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Pepsinogen A1, related Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi aspartyl protease, putative Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium parvum membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva pepsinogen, putative Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Renin, related Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin II Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus granulosus cathepsin d lysosomal aspartyl protease Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva cathepsin E, putative Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl protease ASP1 Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl proteinase (eimepsin), putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii plasmepsin Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin I Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans secretory aspartyl proteinase SAP5p Renin   402 aa 354 aa 24.6 %
Candida albicans secretory aspartyl proteinase SAP4p Renin   402 aa 341 aa 24.3 %
Plasmodium falciparum plasmepsin X Renin   402 aa 332 aa 29.8 %
Plasmodium falciparum plasmepsin III Renin   402 aa 345 aa 29.9 %
Plasmodium knowlesi aspartyl protease, putative Renin   402 aa 369 aa 27.1 %
Candida albicans secretory aspartyl proteinase SAP8p Renin   402 aa 333 aa 23.7 %
Neospora caninum Cathepsin D enzyme (EC 3.4.23.5), related Renin   402 aa 358 aa 30.4 %
Plasmodium yoelii Eukaryotic aspartyl protease, putative Renin   402 aa 329 aa 29.5 %
Candida albicans secretory aspartyl proteinase SAP4p Renin   402 aa 341 aa 24.3 %
Plasmodium falciparum plasmepsin IX Renin   402 aa 438 aa 25.3 %
Babesia bovis aspartyl protease, putative Renin   402 aa 350 aa 28.3 %
Neospora caninum hypothetical protein Renin   402 aa 324 aa 29.6 %
Onchocerca volvulus Sphingomyelin phosphodiesterase 1 homolog Renin   402 aa 414 aa 40.3 %
Babesia bovis aspartyl protease, putative Renin   402 aa 333 aa 25.8 %
Toxoplasma gondii aspartyl protease ASP3 Renin   402 aa 324 aa 29.9 %
Plasmodium falciparum plasmepsin VII Renin   402 aa 367 aa 24.3 %
Candida albicans secretory aspartyl proteinase SAP5p Renin   402 aa 354 aa 24.6 %
Plasmodium vivax aspartyl protease, putative Renin   402 aa 455 aa 25.1 %
Onchocerca volvulus Renin   402 aa 340 aa 30.6 %
Plasmodium falciparum plasmepsin X renin 406 aa 352 aa 26.4 %
Candida albicans secretory aspartyl proteinase SAP8p Renin   402 aa 333 aa 23.7 %
Plasmodium knowlesi eukaryotic aspartyl protease, putative Renin   402 aa 328 aa 28.7 %
Candida albicans secretory aspartyl proteinase SAP10p, related to SAP9p Renin   402 aa 344 aa 21.8 %
Toxoplasma gondii aspartyl protease Renin   402 aa 417 aa 28.5 %
Schistosoma mansoni memapsin-2 (A01 family) Renin   402 aa 440 aa 21.1 %
Loa Loa (eye worm) aspartic protease BmAsp-1 Renin   402 aa 408 aa 26.5 %
Plasmodium berghei plasmepsin VII Renin   402 aa 360 aa 27.2 %
Candida albicans secretory aspartyl proteinase SAP6p Renin   402 aa 341 aa 24.6 %
Candida albicans secretory aspartyl proteinase SAP6p Renin   402 aa 341 aa 24.9 %
Plasmodium vivax aspartyl protease, putative Renin   402 aa 385 aa 27.8 %
Drosophila melanogaster CG31926 gene product from transcript CG31926-RB Renin   402 aa 415 aa 33.5 %
Plasmodium berghei plasmepsin X Renin   402 aa 329 aa 29.8 %
Candida albicans secretory aspartyl proteinase SAP10p, related to SAP9p Renin   402 aa 344 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0103 0.0067 0.008
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0696 0.0681 1
Trichomonas vaginalis conserved hypothetical protein 0.1585 0.1602 0.3168
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0014 0.0123
Loa Loa (eye worm) transcriptional regulator 0.0103 0.0067 0.0066
Echinococcus multilocularis protein jagged 2 0.0214 0.0183 0.0246
Schistosoma mansoni glutamate receptor kainate 0.0068 0.0031 0.0027
Mycobacterium ulcerans thioesterase 0.0078 0.0041 0.0664
Loa Loa (eye worm) hypothetical protein 0.0137 0.0103 0.0102
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4893 0.5027 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.035 0.0324 0.0381
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0067 0.003 0.0937
Schistosoma mansoni hypothetical protein 0.1585 0.1602 0.193
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0132 0.0098 0.0097
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0063 0.0026 0.051
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.035 0.0324 0.4626
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0096 0.006 0.1855
Plasmodium falciparum subtilisin-like protease 1 0.035 0.0324 0.8264
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0103 0.0067 0.0107
Echinococcus granulosus integrin alpha ps 0.0467 0.0445 0.0537
Echinococcus granulosus MAM 0.0092 0.0056 0.0067
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0062 0.0025 0.0768
Loa Loa (eye worm) hypothetical protein 0.0137 0.0103 0.0102
Echinococcus multilocularis fibrillin 1 0.0215 0.0184 0.0248
Loa Loa (eye worm) hypothetical protein 0.0062 0.0026 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Loa Loa (eye worm) hypothetical protein 0.3122 0.3194 0.3193
Echinococcus multilocularis MAM 0.0092 0.0056 0.0075
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0214 0.0183 0.0337
Mycobacterium tuberculosis Probable thioesterase TesA 0.0078 0.0041 0.1279
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.035 0.0324 0.0323
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0051 0.0014 0.0015
Schistosoma mansoni site-1 peptidase (S08 family) 0.035 0.0324 0.0381
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0086 0.005 0.0059
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0103 0.0067 0.008
Echinococcus granulosus protein arginine methyltransferase 0.0063 0.0026 0.003
Echinococcus granulosus membrane bound transcription factor site 1 0.035 0.0324 0.039
Brugia malayi Protein kinase domain containing protein 0.0051 0.0014 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1935 0.1965 0.3892
Mycobacterium leprae Possible secreted protease 0.035 0.0324 1
Loa Loa (eye worm) apoptosis regulator protein 0.0062 0.0026 0.0025
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1935 0.1965 0.3892
Schistosoma mansoni chromatin regulatory protein sir2 0.0696 0.0681 0.0815
Plasmodium falciparum plasmepsin II 0.0152 0.0119 0.2798
Brugia malayi endoprotease bli-4 precursor 0.8015 0.826 0.826
Trypanosoma cruzi UDP-galactopyranose mutase 0.0085 0.0049 0.05
Schistosoma mansoni septate junction protein 0.0059 0.0022 0.0016
Brugia malayi aspartic protease BmAsp-2, identical 0.0062 0.0025 0.0024
Giardia lamblia Furin precursor putative serine protease 0.1585 0.1602 0.5192
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0203 0.0172 0.0231
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0085 0.0049 0.124
Toxoplasma gondii subtilisin SUB2 0.035 0.0324 0.9975
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0152 0.0119 0.0209
Plasmodium vivax aspartyl proteinase, putative 0.0062 0.0025 0.0311
Brugia malayi Will die slowly protein 0.0067 0.003 0.003
Plasmodium falciparum plasmepsin IX 0.0062 0.0025 0.0311
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0103 0.0067 0.009
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0065 0.0028 0.0022
Brugia malayi hypothetical protein 0.0098 0.0062 0.0061
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0051 0.0014 0.0017
Mycobacterium ulcerans Type I modular polyketide synthase 0.009 0.0054 0.1082
Loa Loa (eye worm) hypothetical protein 0.0399 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0574 0.0556 0.0555
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0047 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0065 0.0028 0.0027
Loa Loa (eye worm) proprotein convertase 2 0.1935 0.1965 0.1964
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1935 0.1965 0.237
Schistosoma mansoni discoidin domain receptor 0.0051 0.0014 0.0005
Brugia malayi ADAMTS-like protease 0.0137 0.0103 0.0102
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0332 0.0305 0.0412
Echinococcus multilocularis adam 0.052 0.0499 0.0676
Trypanosoma cruzi UDP-galactopyranose mutase 0.0085 0.0049 0.05
Schistosoma mansoni chromatin regulatory protein sir2 0.0696 0.0681 0.0815
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0203 0.0172 0.0171
Mycobacterium tuberculosis Possible oxidoreductase 0.0085 0.0049 0.1506
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0096 0.006 0.1497
Echinococcus multilocularis disintegrin and metalloproteinase 0.0097 0.0061 0.0082
Schistosoma mansoni glutamate receptor NMDA 0.0322 0.0295 0.0346
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.038 0.0355 0.4723
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0098 0.0062 0.0703
Echinococcus granulosus integrin alpha 3 0.146 0.1473 0.1782
Mycobacterium ulcerans polyketide synthase Pks13 0.0136 0.0102 0.2661
Schistosoma mansoni hypothetical protein 0.0062 0.0026 0.002
Brugia malayi amine oxidase, flavin-containing family protein 0.012 0.0085 0.0084
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1585 0.1602 0.3168
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0087 0.0051 0.005
Schistosoma mansoni apoptosis regulator bax 0.0062 0.0026 0.002
Echinococcus granulosus glutamate NMDA receptor subunit 0.0322 0.0295 0.0356
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.035 0.0324 0.039
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0086 0.005 0.0059
Echinococcus multilocularis 0.0085 0.0049 0.0065
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0062 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0534 0.0514 0.0513
Schistosoma mansoni cathepsin D (A01 family) 0.0382 0.0357 0.0421
Brugia malayi protein kinase C II. 0.0092 0.0056 0.0055
Loa Loa (eye worm) hypothetical protein 0.012 0.0085 0.0084
Onchocerca volvulus 0.0092 0.0056 0.1291
Loa Loa (eye worm) hypothetical protein 0.1489 0.1502 0.1502
Schistosoma mansoni glutamate receptor AMPA 0.0068 0.0031 0.0027
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0234 0.0203 0.0244
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1935 0.1965 0.3892
Giardia lamblia Tenascin-like 0.0214 0.0183 0.039
Loa Loa (eye worm) hypothetical protein 0.0067 0.003 0.0029
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0203 0.0172 0.2225
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0417 0.0393 0.0465
Loa Loa (eye worm) glutamate receptor 1 0.0068 0.0031 0.003
Brugia malayi Pepsin A precursor 0.0062 0.0025 0.0024
Onchocerca volvulus 0.0051 0.0014 0.0296
Loa Loa (eye worm) hypothetical protein 0.0092 0.0056 0.0055
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0072 0.0035 0.0695
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0234 0.0203 0.0235
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0152 0.0119 0.0118
Echinococcus multilocularis Kelch repeat type 1 0.0093 0.0058 0.0076
Schistosoma mansoni integrin beta subunit 0.5668 0.5829 0.7054
Echinococcus multilocularis protoporphyrinogen oxidase 0.0085 0.0049 0.0065
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0096 0.006 0.128
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0062 0.0025 0.0019
Giardia lamblia Tenascin-37 0.0214 0.0183 0.039
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.8015 0.826 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0235 0.0205 0.0204
Mycobacterium ulcerans Type I modular polyketide synthase 0.009 0.0054 0.1082
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0103 0.0067 0.008
Mycobacterium ulcerans polyketide synthase 0.0096 0.006 0.128
Plasmodium falciparum plasmepsin VII 0.0062 0.0025 0.0311
Schistosoma mansoni chromatin regulatory protein sir2 0.0103 0.0067 0.007
Schistosoma mansoni hypothetical protein 0.0467 0.0445 0.0528
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0696 0.0681 1
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0051 0.0014 0.0421
Echinococcus multilocularis integrin alpha 3 0.146 0.1473 0.1997
Echinococcus multilocularis protein kinase c epsilon type 0.0092 0.0056 0.0075
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0203 0.0172 0.0197
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.009 0.0054 0.167
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0103 0.0067 0.0441
Mycobacterium ulcerans Sir2-like regulatory protein 0.0103 0.0067 0.1519
Trypanosoma brucei SIR2-like protein 4, putative 0.0103 0.0067 0.008
Toxoplasma gondii histone deacetylase SIR2 0.0103 0.0067 0.1828
Toxoplasma gondii PA14 domain-containing protein 0.0051 0.0014 0.0123
Brugia malayi transcriptional regulator, Sir2 family protein 0.0103 0.0067 0.0066
Loa Loa (eye worm) sirtuin 4 0.0103 0.0067 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.1585 0.1602 0.3168
Trichomonas vaginalis conserved hypothetical protein 0.035 0.0324 0.0618
Toxoplasma gondii aspartyl protease ASP5 0.0351 0.0324 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0152 0.0119 0.0159
Brugia malayi Subtilase family protein 0.035 0.0324 0.0323
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0203 0.0172 0.0206
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0086 0.005 0.0059
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0203 0.0172 0.2345
Echinococcus granulosus integrin beta 2 0.7156 0.7371 0.8923
Trichomonas vaginalis conserved hypothetical protein 0.1585 0.1602 0.3168
Echinococcus multilocularis protein will die slowly 0.0067 0.003 0.004
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0097 0.0061 0.0082
Echinococcus granulosus disintegrin and metalloproteinase 0.0097 0.0061 0.0073
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0063 0.0026 0.0024
Loa Loa (eye worm) TK/EGFR protein kinase 0.0453 0.043 0.0429
Echinococcus granulosus protein kinase c epsilon type 0.0092 0.0056 0.0067
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0014 0.0123
Echinococcus granulosus epidermal growth factor receptor 0.0453 0.043 0.0519
Schistosoma mansoni amine oxidase 0.0085 0.0049 0.0048
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.038 0.0355 0.5094
Echinococcus multilocularis discoidin domain receptor 0.0051 0.0014 0.0017
Echinococcus granulosus integrin alpha ps 0.1042 0.1039 0.1257
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1935 0.1965 0.3892
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0085 0.0049 0.0936
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0103 0.0067 0.0107
Echinococcus granulosus Furin 1 0.1935 0.1965 0.2377
Brugia malayi Disintegrin family protein 0.0097 0.0061 0.006
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.035 0.0324 0.0381
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0085 0.0049 0.0936
Brugia malayi EGF-like domain containing protein 0.0214 0.0183 0.0182
Giardia lamblia Hypothetical protein 0.0696 0.0681 0.2078
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0103 0.0067 0.008
Loa Loa (eye worm) integrin alpha pat-2 0.2826 0.2887 0.2886
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0014 0.0017
Schistosoma mansoni chromatin regulatory protein sir2 0.0696 0.0681 0.0815
Trypanosoma brucei RNA helicase, putative 0.0101 0.0065 0.0048
Echinococcus multilocularis integrin alpha ps 0.1042 0.1039 0.1409
Brugia malayi Glutamate receptor 1 precursor 0.0068 0.0031 0.003
Plasmodium vivax plasmepsin V, putative 0.0413 0.0389 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0025 0.0024
Loa Loa (eye worm) WD40 repeat protein 0.0067 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0103 0.0067 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Plasmodium falciparum plasmepsin VI 0.0152 0.0119 0.2798
Entamoeba histolytica hypothetical protein 0.0098 0.0062 0.0364
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0332 0.0305 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.1585 0.1602 0.3168
Plasmodium falciparum plasmepsin I 0.0152 0.0119 0.2798
Plasmodium vivax hypothetical protein, conserved 0.0103 0.0067 0.143
Loa Loa (eye worm) hypothetical protein 0.0234 0.0203 0.0202
Echinococcus granulosus furin 0.8015 0.826 1
Echinococcus multilocularis integrin beta 2 0.7156 0.7371 1
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1585 0.1602 0.3168
Loa Loa (eye worm) hypothetical protein 0.15 0.1514 0.1514
Trichomonas vaginalis conserved hypothetical protein 0.1585 0.1602 0.3168
Loa Loa (eye worm) hypothetical protein 0.0081 0.0045 0.0044
Echinococcus multilocularis chromatin regulatory protein sir2 0.0696 0.0681 0.0923
Echinococcus granulosus lysine specific histone demethylase 1A 0.0085 0.0049 0.0058
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.006 0.0024 0.044
Brugia malayi AMP-binding enzyme family protein 0.0087 0.0051 0.005
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0696 0.0681 0.1332
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0063 0.0026 0.0024
Toxoplasma gondii hypothetical protein 0.0214 0.0183 0.5491
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0062 0.0025 0.0019
Echinococcus multilocularis membrane bound transcription factor site 1 0.035 0.0324 0.0437
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0203 0.0172 0.1766
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0062 0.0025 0.0494
Schistosoma mansoni glutamate receptor NMDA 0.0086 0.005 0.0049
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0063 0.0026 0.002
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0069 0.0033 0.0028
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.035 0.0324 1
Schistosoma mansoni hypothetical protein 0.0067 0.003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0214 0.0183 0.0182
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0782 0.0771 0.0932
Toxoplasma gondii subtilisin SUB11 0.035 0.0324 0.9975
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0049 0.0936
Loa Loa (eye worm) hypothetical protein 0.035 0.0324 0.0323
Chlamydia trachomatis glutamine binding protein 0.0088 0.0052 0.0249
Toxoplasma gondii type I fatty acid synthase, putative 0.0066 0.003 0.0633
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Schistosoma mansoni hypothetical protein 0.0062 0.0026 0.002
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0134 0.01 0.0134
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0417 0.0393 0.0532
Toxoplasma gondii histone lysine-specific demethylase 0.0085 0.0049 0.124
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0062 0.0026 0.003
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0047 0.0009 0.001
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0096 0.006 0.1855
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0103 0.0067 0.0107
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0086 0.005 0.0066
Mycobacterium ulcerans NAD-dependent deacetylase 0.0103 0.0067 0.1519
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0173 0.014 0.014
Giardia lamblia High cysteine protein 0.0214 0.0183 0.039
Onchocerca volvulus 0.0162 0.0129 0.2987
Loa Loa (eye worm) hypothetical protein 0.0993 0.0989 0.0988
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0103 0.0067 0.0107
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0172 0.0139 0.4033
Toxoplasma gondii subtilisin SUB10 0.035 0.0324 0.9975
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0063 0.0026 0.002
Echinococcus granulosus glutamate receptor subunit protein glur 0.0047 0.0009 0.001
Brugia malayi EGF-like domain containing protein 0.0214 0.0183 0.0182
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0062 0.0026 0.002
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0306 0.0278 0.0325
Brugia malayi SWIRM domain containing protein 0.0452 0.0429 0.0429
Plasmodium falciparum plasmepsin IV 0.0152 0.0119 0.2798
Loa Loa (eye worm) metalloprotease 0.0065 0.0028 0.0027
Brugia malayi Glutamate receptor 2 precursor 0.0068 0.0031 0.003
Brugia malayi Stress-activated protein kinase jnk-1 0.0235 0.0205 0.0204
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0051 0.0014 0.0017
Toxoplasma gondii subtilisin SUB7 0.035 0.0324 0.9975
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0696 0.0681 0.0824
Loa Loa (eye worm) glutamate receptor 2 0.0068 0.0031 0.003
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4893 0.5027 0.6086
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0103 0.0067 0.0107
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.009 0.0054 0.167
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0103 0.0067 0.0633
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0203 0.0172 0.4213
Trichomonas vaginalis conserved hypothetical protein 0.1585 0.1602 0.3168
Toxoplasma gondii subtilisin SUB4 0.035 0.0324 0.9975
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0203 0.0172 0.4213
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.038 0.0355 0.5094
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0696 0.0681 0.0923
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0103 0.0067 0.0107
Loa Loa (eye worm) hypothetical protein 0.0085 0.0049 0.0048
Plasmodium falciparum subtilisin-like protease 3 0.035 0.0324 0.8264
Echinococcus granulosus protein arginine N methyltransferase 8 0.0063 0.0026 0.003
Loa Loa (eye worm) transcriptional regulator 0.0103 0.0067 0.0066
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.035 0.0324 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0047 0.0009 0.0011
Echinococcus multilocularis Furin 1 0.1935 0.1965 0.2664
Toxoplasma gondii subtilisin SUB1 0.035 0.0324 0.9975
Brugia malayi hypothetical protein 0.1489 0.1502 0.1502
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0085 0.0049 0.0936
Brugia malayi EGF-like domain containing protein 0.0214 0.0183 0.0182
Schistosoma mansoni protein kinase 0.0151 0.0117 0.0131
Loa Loa (eye worm) angiogenesis inhibito 0.0065 0.0028 0.0027
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0062 0.0025 0.0019
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0062 0.0025 0.0019
Toxoplasma gondii subtilisin SUB8 0.035 0.0324 0.9975
Echinococcus multilocularis glutamate receptor 2 0.0068 0.0031 0.0041
Schistosoma mansoni protein kinase 0.0151 0.0117 0.0131
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0172 0.0139 0.0249
Brugia malayi Kelch motif family protein 0.1519 0.1534 0.1533
Echinococcus multilocularis serine:threonine protein kinase N2 0.0084 0.0048 0.0064
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.035 0.0324 1
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.035 0.0324 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0103 0.0067 0.007
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0152 0.0119 0.3459
Echinococcus granulosus chromatin regulatory protein sir2 0.0696 0.0681 0.0824
Giardia lamblia Tenascin precursor 0.0214 0.0183 0.039
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0096 0.006 0.1855
Schistosoma mansoni integrin alpha 0.1968 0.1998 0.2411
Trichomonas vaginalis conserved hypothetical protein 0.1585 0.1602 0.3168
Loa Loa (eye worm) hypothetical protein 0.8015 0.826 0.826
Trichomonas vaginalis hypothetical protein 0.1585 0.1602 0.3168
Brugia malayi hypothetical protein 0.0062 0.0025 0.0024
Echinococcus granulosus fibrillin 1 0.0215 0.0184 0.0221
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Brugia malayi hypothetical protein 0.0062 0.0025 0.0024
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0172 0.0139 0.5
Loa Loa (eye worm) TK/ALK protein kinase 0.0092 0.0056 0.0055
Brugia malayi transcriptional regulator, Sir2 family protein 0.0696 0.0681 0.0681
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0063 0.0026 0.0033
Toxoplasma gondii subtilisin SUB6 0.035 0.0324 0.9975
Schistosoma mansoni glutamate receptor kainate 0.0068 0.0031 0.0027
Brugia malayi Reprolysin 0.0137 0.0103 0.0102
Loa Loa (eye worm) hypothetical protein 0.0085 0.0049 0.0048
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0151 0.0117 0.0157
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0696 0.0681 1
Schistosoma mansoni dihydroceramide desaturase 0.0097 0.0061 0.0063
Loa Loa (eye worm) aspartyl protease 6 0.0062 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0098 0.0062 0.0061
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1392 0.1402 0.1402
Loa Loa (eye worm) hypothetical protein 0.0051 0.0014 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.1585 0.1602 0.3168
Echinococcus multilocularis glutamate receptor 2 0.0086 0.005 0.0066
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.035 0.0324 0.0381
Brugia malayi metalloprotease 0.0065 0.0028 0.0027
Echinococcus granulosus adam 17 protease 0.0097 0.0061 0.0073
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0014 0.0015
Toxoplasma gondii aspartyl protease ASP1 0.0152 0.0119 0.3459
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1935 0.1965 0.3892
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Schistosoma mansoni hypothetical protein 0.0093 0.0058 0.0058
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0085 0.0049 0.0907
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0096 0.006 0.1497
Echinococcus multilocularis kelch ECH associated protein 1 0.0093 0.0057 0.0076
Loa Loa (eye worm) hypothetical protein 0.0062 0.0025 0.0024
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0014 0.0123
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0234 0.0203 0.0235
Echinococcus granulosus kelch ECH associated protein 1 0.0093 0.0057 0.0068
Brugia malayi transcriptional regulator, Sir2 family protein 0.0103 0.0067 0.0066
Schistosoma mansoni hypothetical protein 0.0062 0.0026 0.002
Mycobacterium tuberculosis Polyketide synthase Pks2 0.009 0.0055 0.1685
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0103 0.0067 0.0107
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0234 0.0203 0.0274
Schistosoma mansoni hypothetical protein 0.0092 0.0056 0.0057
Schistosoma mansoni btb and poz domain-containing protein 0.0051 0.0014 0.0005
Toxoplasma gondii subtilisin SUB12 0.035 0.0324 0.9975
Brugia malayi celfurPC protein 0.643 0.6619 0.6618
Loa Loa (eye worm) endoprotease bli-4 0.8015 0.826 0.826
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0103 0.0067 0.009
Echinococcus multilocularis epidermal growth factor receptor 0.0453 0.043 0.0582
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0062 0.0061
Plasmodium vivax NAD-dependent deacetylase, putative 0.0103 0.0067 0.143
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0696 0.0681 0.1332
Schistosoma mansoni ATP-binding cassette transporter 0.0071 0.0034 0.003
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0085 0.0049 0.0936
Leishmania major subtilisin-like serine peptidase 0.035 0.0324 0.4542
Schistosoma mansoni glutamate receptor AMPA 0.0068 0.0031 0.0027
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0063 0.0026 0.002
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0062 0.0026 0.0025
Loa Loa (eye worm) acyl carrier protein 0.0043 0.0005 0.0004
Loa Loa (eye worm) fatty acid synthase 0.0092 0.0056 0.0055
Mycobacterium ulcerans thioesterase TesA 0.0078 0.0041 0.0664
Loa Loa (eye worm) transcriptional regulator 0.0696 0.0681 0.0681
Brugia malayi NAD-dependent deacetylase SIRT1 0.0103 0.0067 0.0066
Loa Loa (eye worm) hypothetical protein 0.0051 0.0014 0.0013
Plasmodium falciparum plasmepsin X 0.0062 0.0025 0.0311
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0062 0.0025 0.0019
Toxoplasma gondii subtilisin SUB5 0.035 0.0324 0.9975
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0132 0.0098 0.0097
Schistosoma mansoni integrin alpha-ps 0.0574 0.0556 0.0662
Schistosoma mansoni discoidin domain receptor 0.0051 0.0014 0.0005
Echinococcus granulosus fibrillin 2 0.0214 0.0183 0.022
Echinococcus multilocularis integrin alpha ps 0.0467 0.0445 0.0602
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0086 0.005 0.0066
Echinococcus granulosus glutamate receptor 2 0.0086 0.005 0.0059
Mycobacterium ulcerans dehydrogenase 0.0085 0.0049 0.0907
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0014 0.0017
Giardia lamblia Neurogenic locus Notch protein precursor 0.0214 0.0183 0.039
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0096 0.006 0.128
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.035 0.0324 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Plasmodium vivax plasmepsin IV, putative 0.0152 0.0119 0.2798
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0085 0.0049 0.0048
Mycobacterium ulcerans Type I modular polyketide synthase 0.009 0.0054 0.1082
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0103 0.0067 0.2079
Onchocerca volvulus 0.0214 0.0183 0.4237
Echinococcus granulosus kelch ECH associated protein 1 like 0.0093 0.0057 0.0068
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Trypanosoma cruzi subtilisin peptidase 0.035 0.0324 0.4626
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0322 0.0295 0.0398
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.035 0.0324 1
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1585 0.1602 0.3168
Giardia lamblia High cysteine protein 0.0214 0.0183 0.039
Loa Loa (eye worm) hypothetical protein 0.0072 0.0036 0.0035
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.035 0.0324 1
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0047 0.0009 0.0011
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0782 0.0771 0.1044
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0235 0.0205 0.0276
Schistosoma mansoni dock 0.0051 0.0014 0.0005
Brugia malayi Integrin alpha pat-2 precursor 0.1968 0.1998 0.1997
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.009 0.0054 0.1304
Toxoplasma gondii subtilisin SUB9 0.035 0.0324 0.9975
Loa Loa (eye worm) integrin beta-2 0.9696 1 1
Onchocerca volvulus 0.0067 0.003 0.0689
Echinococcus granulosus nmda type glutamate receptor 0.0134 0.01 0.012
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0086 0.005 0.0066
Loa Loa (eye worm) hypothetical protein 0.0214 0.0183 0.0182
Brugia malayi neuroendocrine convertase 1 precursor 0.5057 0.5197 0.5197
Plasmodium vivax subtilisin-like protease 1 0.035 0.0324 0.8264
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0049 0.0936
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0047 0.0009 0.001
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0097 0.0061 0.0073
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0203 0.0172 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0152 0.0119 0.0132
Mycobacterium tuberculosis Conserved hypothetical protein 0.0085 0.0049 0.1506
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0203 0.0172 0.0171
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0098 0.0062 0.0703
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0072 0.0035 0.0458
Plasmodium falciparum protoporphyrinogen oxidase 0.0085 0.0049 0.0936
Loa Loa (eye worm) subtilase 0.035 0.0324 0.0323
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0103 0.0067 0.0778
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0085 0.0049 0.0907
Giardia lamblia Tenascin-X 0.0214 0.0183 0.039
Loa Loa (eye worm) hypothetical protein 0.0097 0.0061 0.006
Loa Loa (eye worm) hypothetical protein 0.0214 0.0183 0.0182
Onchocerca volvulus 0.0062 0.0025 0.0568
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0203 0.0172 1
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0063 0.0026 0.0324
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4893 0.5027 0.682
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0103 0.0067 0.0107
Brugia malayi ADAM-TS Spacer 1 family protein 0.0137 0.0103 0.0102
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0098 0.0062 0.0364
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0696 0.0681 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4893 0.5027 1
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0136 0.0102 0.3145
Giardia lamblia High cysteine membrane protein Group 2 0.2958 0.3023 1
Plasmodium falciparum plasmepsin V 0.0413 0.0389 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0062 0.0026 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Brugia malayi hypothetical protein 0.0092 0.0056 0.0055
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0103 0.0067 0.009
Echinococcus multilocularis kelch ECH associated protein 1 0.0093 0.0057 0.0076
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0088 0.0052 0.1601
Onchocerca volvulus 0.035 0.0324 0.7529
Brugia malayi angiogenesis inhibito 0.0137 0.0103 0.0102
Schistosoma mansoni memapsin-2 (A01 family) 0.0062 0.0025 0.0019
Loa Loa (eye worm) hypothetical protein 0.0452 0.0429 0.0429
Loa Loa (eye worm) hypothetical protein 0.0153 0.012 0.0119
Loa Loa (eye worm) hypothetical protein 0.0417 0.0393 0.0392
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0062 0.0025 0.0019
Onchocerca volvulus 0.0452 0.0429 1
Leishmania major silent information regulator 2, putative 0.0696 0.0681 1
Brugia malayi aspartic protease BmAsp-1, identical 0.0062 0.0025 0.0024
Mycobacterium leprae Polyketide synthase Pks13 0.0136 0.0102 0.2844
Schistosoma mansoni hypothetical protein 0.0101 0.0065 0.0068
Trichomonas vaginalis hypothetical protein 0.0214 0.0183 0.0337
Trichomonas vaginalis WD repeat domain, putative 0.0067 0.003 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Toxoplasma gondii type I fatty acid synthase, putative 0.0096 0.006 0.1598
Mycobacterium ulcerans polyketide synthase 0.009 0.0054 0.1082
Plasmodium falciparum plasmepsin VIII, putative 0.0062 0.0025 0.0311
Loa Loa (eye worm) hypothetical protein 0.0092 0.0056 0.0055
Onchocerca volvulus 0.0087 0.0051 0.1171
Echinococcus granulosus adam 0.052 0.0499 0.0603
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.009 0.0054 0.0053
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0203 0.0172 0.5146
Plasmodium vivax aspartyl protease, putative 0.0062 0.0025 0.0311
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0062 0.0061
Brugia malayi proprotein convertase 2 0.5057 0.5197 0.5197
Loa Loa (eye worm) hypothetical protein 0.0067 0.003 0.0029
Plasmodium vivax aspartyl proteinase, putative 0.0152 0.0119 0.2798
Plasmodium falciparum subtilisin-like protease 2 0.035 0.0324 0.8264
Brugia malayi hypothetical protein 0.0085 0.0049 0.0048
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0078 0.0041 0.0896
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0014 0.0017
Mycobacterium leprae Probable polyketide synthase Pks1 0.0096 0.006 0.1497
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1935 0.1965 0.3892
Giardia lamblia hypothetical protein 0.0214 0.0183 0.039
Schistosoma mansoni protein kinase 0.0151 0.0117 0.0131
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0103 0.0067 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.1585 0.1602 0.3168
Schistosoma mansoni integrin alpha-ps 0.0975 0.097 0.1165
Toxoplasma gondii histone deacetylase SIR2-like 0.0103 0.0067 0.1828
Schistosoma mansoni furin-1 (S08 family) 0.3472 0.3556 0.4299
Echinococcus multilocularis 0.643 0.6619 0.898
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0103 0.0067 0.0441
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0073 0.0036 0.1126
Echinococcus granulosus c-Jun N-terminal kinases 0.0235 0.0205 0.0246
Schistosoma mansoni amine oxidase 0.0085 0.0049 0.0048
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0086 0.005 0.0059
Schistosoma mansoni chromatin regulatory protein sir2 0.0103 0.0067 0.007
Echinococcus multilocularis integrin alpha ps 0.0975 0.097 0.1315
Echinococcus multilocularis neuroendocrine convertase 2 0.5057 0.5197 0.7051
Toxoplasma gondii aspartyl protease ASP3 0.0062 0.0025 0.0494
Schistosoma mansoni chromatin regulatory protein sir2 0.0103 0.0067 0.007
Echinococcus multilocularis nmda type glutamate receptor 0.0134 0.01 0.0134
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0058 0.0021 0.0249
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.009 0.0054 0.1082
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0014 0.0015
Loa Loa (eye worm) hypothetical protein 0.0214 0.0183 0.0182
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Echinococcus granulosus neuroendocrine convertase 2 0.5057 0.5197 0.6292
Trichomonas vaginalis conserved hypothetical protein 0.035 0.0324 0.0618
Loa Loa (eye worm) hypothetical protein 0.0092 0.0056 0.0055
Schistosoma mansoni hypothetical protein 0.0092 0.0056 0.0057
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1229 0.1233 0.1484
Onchocerca volvulus 0.0062 0.0025 0.0568
Schistosoma mansoni tyrosine kinase 0.0453 0.043 0.051
Plasmodium falciparum plasmepsin III 0.0062 0.0025 0.0311
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0172 0.0139 0.4284
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0056 0.0057
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.009 0.0054 0.1304
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0399 0.0374 0.0374
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0063 0.0026 0.0324
Brugia malayi Furin-like cysteine rich region family protein 0.0453 0.043 0.0429
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.009 0.0055 0.1685
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0092 0.0056 0.0055
Onchocerca volvulus 0.0051 0.0014 0.0296
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.009 0.0054 0.167
Echinococcus granulosus discoidin domain receptor 0.0051 0.0014 0.0015
Leishmania major sir2-family protein-like protein 0.0103 0.0067 0.0633
Mycobacterium ulcerans monoamine oxidase 0.0085 0.0049 0.0907
Plasmodium vivax subtilisin-like protease 2, putative 0.035 0.0324 0.8264
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.035 0.0324 1
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0085 0.0049 0.1133
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.035 0.0324 1
Loa Loa (eye worm) hypothetical protein 0.0417 0.0393 0.0392
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0088 0.0052 0.1008
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0103 0.0067 0.0778
Trichomonas vaginalis conserved hypothetical protein 0.1585 0.1602 0.3168
Echinococcus multilocularis NMDA receptor 0.0047 0.0009 0.0011
Echinococcus multilocularis protein arginine methyltransferase 0.0063 0.0026 0.0033
Loa Loa (eye worm) hypothetical protein 0.0049 0.0012 0.0011
Onchocerca volvulus 0.0092 0.0056 0.1291
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0087 0.0051 0.1581
Schistosoma mansoni hypothetical protein 0.0067 0.003 0.0026
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0062 0.0025 0.0019
Mycobacterium ulcerans oxidoreductase 0.0085 0.0049 0.0907
Echinococcus granulosus lysine specific histone demethylase 1A 0.0417 0.0393 0.0474
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0103 0.0067 0.143
Leishmania major UDP-galactopyranose mutase 0.0085 0.0049 0.035
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.035 0.0324 0.0437
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0086 0.005 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.035 0.0324 0.0618
Echinococcus multilocularis fibrillin 2 0.0214 0.0183 0.0246
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.035 0.0324 0.0618
Giardia lamblia Neurogenic locus notch-like protein 0.0214 0.0183 0.039
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0063 0.0026 0.0024
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0696 0.0681 1
Plasmodium vivax aspartyl protease, putative 0.0062 0.0025 0.0311
Plasmodium vivax aspartyl protease, putative 0.0062 0.0025 0.0311
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0053 0.0016 0.049
Brugia malayi Eukaryotic aspartyl protease family protein 0.0062 0.0025 0.0024
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.035 0.0324 0.0323
Schistosoma mansoni serine/threonine protein kinase 0.0235 0.0205 0.0237
Echinococcus granulosus protein will die slowly 0.0067 0.003 0.0035
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0151 0.0117 0.014
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0085 0.0049 0.0907
Brugia malayi Protein kinase domain containing protein 0.0092 0.0056 0.0055
Schistosoma mansoni hypothetical protein 0.0051 0.0014 0.0005
Loa Loa (eye worm) hypothetical protein 0.1392 0.1402 0.1402
Brugia malayi hypothetical protein 0.0306 0.0278 0.0277
Echinococcus granulosus kelch ECH associated protein 1 like 0.0093 0.0057 0.0068
Loa Loa (eye worm) hypothetical protein 0.0152 0.0119 0.0118
Onchocerca volvulus 0.0132 0.0098 0.2265
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.003 0.0029
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0014 0.0015
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0152 0.0119 0.0142
Brugia malayi EGF-like domain containing protein 0.0214 0.0183 0.0182
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0062 0.0025 0.0019
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0047 0.0009 0.001
Echinococcus granulosus serine:threonine protein kinase N2 0.0075 0.0039 0.0046
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0088 0.0052 0.0249
Entamoeba histolytica hypothetical protein, conserved 0.0103 0.0067 0.0441
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0223 0.0192 0.0222
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0136 0.0102 0.3145
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0172 0.0139 0.388
Trichomonas vaginalis conserved hypothetical protein 0.035 0.0324 0.0618
Schistosoma mansoni glutamate receptor kainate 0.0068 0.0031 0.0027
Onchocerca volvulus Fatty acid synthase homolog 0.0168 0.0135 0.3127
Loa Loa (eye worm) reprolysin 0.0234 0.0203 0.0202
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0072 0.0035 0.0458
Trypanosoma brucei subtilisin peptidase 0.035 0.0324 0.422
Plasmodium vivax subtilisin-like serine protease, putative 0.035 0.0324 0.8264
Trichomonas vaginalis conserved hypothetical protein 0.1585 0.1602 0.3168
Toxoplasma gondii aspartyl protease 0.0062 0.0025 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.035 0.0324 0.0618
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0103 0.0067 0.143
Schistosoma mansoni cathepsin D (A01 family) 0.0382 0.0357 0.0421
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1519 0.1534 0.1533

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.00000000024 M Selectivity against rhesus monkey plasma renin ChEMBL. 8410992
IC50 (binding) = 0.00000000024 M Selectivity against rhesus monkey plasma renin ChEMBL. 8410992
IC50 (binding) = 0.0000000055 M Selectivity against guinea pig plasma renin ChEMBL. 8410992
IC50 (binding) = 0.0000000055 M Selectivity against guinea pig plasma renin ChEMBL. 8410992
IC50 (binding) = 0.0000000125 M Selectivity against sheep plasma renin ChEMBL. 8410992
IC50 (binding) = 0.0000000125 M Selectivity against sheep plasma renin ChEMBL. 8410992
IC50 (binding) = 0.000000015 M Selectivity against dog plasma renin ChEMBL. 8410992
IC50 (binding) = 0.000000015 M Selectivity against dog plasma renin ChEMBL. 8410992
IC50 (binding) = 0.00000255 M Selectivity against rat plasma renin ChEMBL. 8410992
IC50 (binding) = 0.00000255 M Selectivity against rat plasma renin ChEMBL. 8410992
IC50 (binding) > 0.0001 M Selectivity against human pepsin ChEMBL. 8410992
IC50 (binding) > 0.0001 M Selectivity against human gastricsin ChEMBL. 8410992
IC50 (binding) > 0.0001 M Selectivity against human cathepsin D ChEMBL. 8410992
IC50 (binding) > 0.0001 M Selectivity against human cathepsin E ChEMBL. 8410992
IC50 (binding) > 0.0001 M Selectivity against human pepsin ChEMBL. 8410992
IC50 (binding) > 0.0001 M Selectivity against human gastricsin ChEMBL. 8410992
IC50 (binding) > 0.0001 M Selectivity against human cathepsin D ChEMBL. 8410992
IC50 (binding) > 0.0001 M Selectivity against human cathepsin E ChEMBL. 8410992
IC50 (binding) = 0.38 nM In vitro inhibition of renin in human plasma ChEMBL. 8410992
IC50 (binding) = 0.38 nM In vitro inhibition of renin in human plasma ChEMBL. 8410992
IC50 (binding) = 0.39 nM In vitro inhibition of purified human kidney renin ChEMBL. 8410992
IC50 (binding) = 0.39 nM In vitro inhibition of purified human kidney renin ChEMBL. 8410992
T1/2 (ADMET) = 91 min Half-life of the compound was determined ChEMBL. 8410992

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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