Detailed information for compound 1577210

Basic information

Technical information
  • TDR Targets ID: 1577210
  • Name: 1-methoxy-4-(phenylmethyl)benzene
  • MW: 198.26 | Formula: C14H14O
  • H donors: 0 H acceptors: 0 LogP: 3.81 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Cc1ccccc1
  • InChi: 1S/C14H14O/c1-15-14-9-7-13(8-10-14)11-12-5-3-2-4-6-12/h2-10H,11H2,1H3
  • InChiKey: GQLYCRTUQGSDSM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(benzyl)-4-methoxy-benzene
  • 834-14-0
  • 1-Benzyl-4-methoxybenzene
  • Anisole, p-benzyl-
  • Benzene, 1-methoxy-4-(phenylmethyl)-
  • NSC2413
  • p-Benzylanisole
  • ZINC01640891
  • InChI=1/C14H14O/c1-15-14-9-7-13(8-10-14)11-12-5-3-2-4-6-12/h2-10H,11H2,1H

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0094 0.046
Onchocerca volvulus 0.0096 0.02 0.173
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0025 0.012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0052 0.0617
Giardia lamblia Fructose-bisphosphate aldolase 0.0289 0.067 1
Onchocerca volvulus 0.0142 0.0313 0.2714
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.02 0.0301
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.011
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0167 0.0374 0.4521
Echinococcus multilocularis GPCR, family 2 0.0048 0.0085 0.0083
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0038 0.0443
Echinococcus multilocularis Smad4 0.0016 0.0007 0.0005
Leishmania major DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0057 0.0835
Echinococcus multilocularis cpg binding protein 0.01 0.0211 0.0209
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0029 0.0038 0.0443
Echinococcus granulosus muscleblind protein 0.078 0.1862 0.2817
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0019 0.0014 0.0071
Echinococcus granulosus cpg binding protein 0.01 0.0211 0.0317
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0002 0.0011
Echinococcus granulosus snurportin 1 0.0312 0.0726 0.1097
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0027 0.0139
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.067 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0071 0.0105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0011 0.0014
Echinococcus multilocularis protein dispatched 1 0.0049 0.0087 0.0085
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0071 0.0846
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Onchocerca volvulus 0.0036 0.0054 0.0462
Onchocerca volvulus 0.0036 0.0054 0.0462
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0052 0.0617
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.0481 0.581
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0011 0.0014
Loa Loa (eye worm) matrixin family protein 0.0045 0.0078 0.0382
Plasmodium vivax SET domain protein, putative 0.0064 0.0123 0.5773
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0057 0.0292
Schistosoma mansoni hypothetical protein 0.0185 0.0418 0.0631
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0027 0.0077
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0052 0.0267
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0048
Loa Loa (eye worm) hypothetical protein 0.0242 0.0556 0.2759
Onchocerca volvulus 0.0036 0.0054 0.0462
Echinococcus multilocularis dnaJ subfamily B 0.0479 0.113 0.1128
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0006 0.0004
Onchocerca volvulus Matrilysin homolog 0.0045 0.0078 0.0667
Trypanosoma cruzi DNA repair protein, putative 0.0037 0.0059 0.0694
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0206 0.1021
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0142 0.0313 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0011 0.0053
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0176 0.0264
Mycobacterium ulcerans hypothetical protein 0.0036 0.0054 0.0161
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0146 0.0443
Echinococcus multilocularis snurportin 1 0.0312 0.0726 0.0724
Loa Loa (eye worm) hypothetical protein 0.0142 0.0313 0.1553
Mycobacterium tuberculosis Carboxylesterase LipT 0.0142 0.0313 0.0334
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0012 0.001
Mycobacterium tuberculosis Conserved protein 0.0036 0.0054 0.0052
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0027 0.0038
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0052 0.005
Schistosoma mansoni alpha glucosidase 0.0037 0.0057 0.0084
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0006 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.0825 0.421
Loa Loa (eye worm) hypothetical protein 0.0073 0.0146 0.0718
Schistosoma mansoni gabp alpha 0.0085 0.0174 0.0261
Echinococcus granulosus carboxylesterase 5A 0.0841 0.201 0.3041
Mycobacterium tuberculosis Conserved protein 0.0024 0.0027 0.0023
Brugia malayi steroid hormone receptor 0.0018 0.0011 0.0053
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0064 0.2954
Loa Loa (eye worm) carboxylesterase 0.0142 0.0313 0.1553
Echinococcus granulosus neuroligin 0.0142 0.0313 0.0472
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0054 0.008
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0153 0.1196
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0052 0.0617
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0054 0.0278
Plasmodium vivax importin-beta 2, putative 0.0029 0.0039 0.1774
Schistosoma mansoni smad1 5 8 and 0.0016 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0064 0.0123 0.0603
Loa Loa (eye worm) hypothetical protein 0.0142 0.0313 0.1553
Echinococcus granulosus acetylcholinesterase 0.0841 0.201 0.3041
Trypanosoma brucei chrX additional, unordered contigs 0.0014 0.0002 0.0011
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0057 0.0677
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0054 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0239 0.1218
Entamoeba histolytica G protein alpha subunit, putative 0.0014 0.0002 0.0008
Mycobacterium ulcerans hypothetical protein 0.0024 0.0027 0.0077
Loa Loa (eye worm) RecQ helicase 0.0023 0.0025 0.0115
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0048 0.0086 0.0127
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0006 0.0007
Echinococcus multilocularis disco interacting protein 2 0.0049 0.0087 0.0085
Loa Loa (eye worm) hypothetical protein 0.0073 0.0146 0.0718
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0038 0.0186
Schistosoma mansoni smad1 5 8 and 0.0016 0.0007 0.0008
Trypanosoma brucei unspecified product 0.0031 0.0044 0.0515
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.002 0.0018
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0029 0.0038 0.011
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0072 0.0107
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0011 0.0009
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0019 0.0014 0.0152
Brugia malayi hypothetical protein 0.0014 0.0002 0.0007
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0098 0.0206 0.0629
Schistosoma mansoni cpg binding protein 0.01 0.0211 0.0317
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0054 0.2502
Schistosoma mansoni patched 1 0.0043 0.0072 0.0107
Onchocerca volvulus 0.0029 0.0038 0.0318
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0025 0.1068
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0027 0.0025
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0206 0.2477
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0032 0.1413
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0038 0.0182
Loa Loa (eye worm) hypothetical protein 0.0142 0.0313 0.1553
Mycobacterium tuberculosis Conserved protein 0.0036 0.0054 0.0052
Plasmodium vivax protein kinase Crk2 0.0086 0.0176 0.8334
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0011 0.0084
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0064 0.0326
Onchocerca volvulus 0.0142 0.0313 0.2714
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0064 0.0922
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0052 0.0267
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0054 0.008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.067 0.342
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0012 0.001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0062 0.0091
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0071 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0275 0.0414
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0025 0.0281
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0292
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0075 0.0888
Leishmania major hypothetical protein, conserved 0.0211 0.0481 0.581
Loa Loa (eye worm) carboxylesterase 0.0142 0.0313 0.1553
Trypanosoma cruzi DNA polymerase eta, putative 0.0075 0.015 0.1805
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0021 0.0273
Leishmania major GTP-binding protein, putative 0.0022 0.0021 0.0232
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0014 0.0002 0.001
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0021 0.0028
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0052 0.0617
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.011
Onchocerca volvulus 0.0064 0.0123 0.1055
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0369 0.0367
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0057 0.2292
Plasmodium falciparum protein kinase 5 0.0086 0.0176 0.8334
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0029 0.0038 0.0034
Mycobacterium tuberculosis Probable reductase 0.0228 0.0521 0.0561
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0006 0.0024
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0025 0.0028 0.0138
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0025 0.0929
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.067 0.342
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0014 0.0002 0.0007
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0025 0.0034
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0052 0.0076
Giardia lamblia Kinase, CMGC CDK 0.0086 0.0176 0.2601
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0153 0.0464
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0153 0.1196
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0054 0.0052
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0153 0.0464
Leishmania major DNA polymerase kappa, putative 0.0014 0.0002 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0239 0.1218
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.002 0.0018 0.0024
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0311 0.0881
Brugia malayi Matrixin family protein 0.002 0.0018 0.0086
Plasmodium falciparum acyl-CoA synthetase 0.0073 0.0146 0.6876
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.0555 0.0553
Echinococcus granulosus peregrin 0.004 0.0066 0.0097
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0064 0.0758
Trypanosoma brucei cdc2-related kinase 3 0.0086 0.0176 0.2117
Echinococcus multilocularis smad 0.0016 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0142 0.0313 0.1553
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.0315 0.0474
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0038 0.0443
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0052 0.0155
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.0315 0.0313
Schistosoma mansoni survival motor neuron protein 0.0049 0.0088 0.013
Trichomonas vaginalis glutaminase, putative 0.082 0.196 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0025 0.0125
Loa Loa (eye worm) hypothetical protein 0.0075 0.015 0.0741
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0115 0.0564
Brugia malayi Protein kinase domain containing protein 0.0086 0.0176 0.0873
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0111 0.0239 0.1182
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.0089 0.1061
Loa Loa (eye worm) hypothetical protein 0.0142 0.0313 0.1553
Schistosoma mansoni ran 0.0022 0.0021 0.0028
Loa Loa (eye worm) hypothetical protein 0.0152 0.0337 0.1672
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0141 0.5776
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0019 0.0014 0.0071
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0014 0.0002 0.0007
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0098 0.0206 0.0629
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0007 0.003
Schistosoma mansoni hypothetical protein 0.0041 0.0069 0.0101
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0029 0.0038 0.0443
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0505 0.1195 0.1194
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0006 0.0004
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0006 0.0168
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0071 0.1031
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0026 0.0132
Brugia malayi serine/threonine-protein kinase plk-2 0.0111 0.0239 0.1186
Entamoeba histolytica acyl-CoA synthetase, putative 0.0098 0.0206 0.3054
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0035 0.1351
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0206 0.0629
Onchocerca volvulus 0.0049 0.0088 0.0753
Echinococcus multilocularis dna polymerase eta 0.0075 0.015 0.0148
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0007 0.0005
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0052 0.2399
Loa Loa (eye worm) hypothetical protein 0.078 0.1862 0.9264
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0228 0.0521 0.1536
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.015 0.0745
Trichomonas vaginalis set domain proteins, putative 0.0487 0.115 0.5869
Loa Loa (eye worm) glutathione reductase 0.01 0.0211 0.1042
Brugia malayi beta-lactamase family protein 0.0036 0.0054 0.0268
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0052 0.0617
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0054 0.0161
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0014 0.0002 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.011
Schistosoma mansoni ap endonuclease 0.0039 0.0064 0.0094
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0052 0.2086
Onchocerca volvulus 0.0014 0.0002 0.0005
Onchocerca volvulus 0.002 0.0018 0.0143
Brugia malayi Thioredoxin reductase 0.01 0.0211 0.1046
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0211 0.0316
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0054 0.008
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0275 0.0414
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0026 0.0296
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0019 0.0014 0.0071
Schistosoma mansoni SET domain protein 0.0019 0.0015 0.002
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.0369 0.1835
Schistosoma mansoni kinase 0.0057 0.0107 0.0159
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1208 0.6161
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0048
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0025 0.0028 0.0026
Brugia malayi Hemopexin family protein 0.0029 0.0038 0.0189
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0011 0.0053
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0211 0.3129
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0011 0.0009
Onchocerca volvulus Glucosylceramidase homolog 0.0335 0.0781 0.6789
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0025 0.0028 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0054 0.0643
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0071 0.0846
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0097 0.0204 0.1015
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0052 0.0179
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0064 0.0062
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0029 0.0038 0.011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0011 0.0048
Echinococcus multilocularis muscleblind protein 0.078 0.1862 0.1861
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0029 0.0038 0.011
Schistosoma mansoni cpg binding protein 0.0097 0.0203 0.0305
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0007
Trypanosoma cruzi cdc2-related kinase 1 0.0086 0.0176 0.2117
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.01 0.0211 0.0223
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0062 0.0302
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0025 0.0029 0.0024
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0311 0.0332
Onchocerca volvulus 0.0142 0.0313 0.2714
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0057 0.0677
Giardia lamblia Non ATPase subunit MPR1 of 26S proteasome 0.0019 0.0014 0.0175
Mycobacterium tuberculosis Probable oxidoreductase 0.0253 0.0583 0.0628
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0025 0.0029 0.014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0011 0.0053
Schistosoma mansoni ap endonuclease 0.0039 0.0064 0.0094
Echinococcus granulosus acetylcholinesterase 0.0841 0.201 0.3041
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0014 0.0002 0.0003
Onchocerca volvulus Serine\/threonine kinase homolog 0.0111 0.0239 0.2066
Echinococcus granulosus DNA methyltransferase 2, putative 0.0023 0.0024 0.0034
Trypanosoma brucei unspecified product 0.0031 0.0044 0.0515
Entamoeba histolytica Ran family GTPase 0.0022 0.0021 0.0286
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0211 0.0209
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0039 0.0188
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0112 0.0339
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0027 0.0077
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0123 0.502
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0052 0.0617
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0098 0.0206 0.0629
Giardia lamblia PHD finger protein 15 0.0029 0.0039 0.0552
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0007 0.0008
Mycobacterium tuberculosis Conserved hypothetical protein 0.0186 0.042 0.0451
Trypanosoma brucei cdc2-related kinase 1 0.0086 0.0176 0.2117
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0011 0.0009
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0052 0.0749
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0123 0.0121
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0073 0.0146 0.0152
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0078 0.0398
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.011
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0038 0.0182
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0153 0.0228
Brugia malayi nuclear hormone receptor 0.0018 0.0011 0.0053
Echinococcus granulosus GA binding protein alpha chain 0.0085 0.0174 0.0261
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0052 0.0617
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0085 0.0126
Echinococcus granulosus GPCR family 2 0.0048 0.0085 0.0126
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.0274 0.0412
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1208 0.6161
Onchocerca volvulus 0.0097 0.0204 0.1767
Loa Loa (eye worm) glutaminase 2 0.082 0.196 0.975
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0253 0.0583 0.0628
Echinococcus granulosus importin subunit beta 1 0.0029 0.0039 0.0057
Brugia malayi MH2 domain containing protein 0.0016 0.0007 0.0034
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0228 0.0521 0.0561
Trypanosoma cruzi cdc2-related kinase 1 0.0086 0.0176 0.2117
Entamoeba histolytica cell division protein kinase 2, putative 0.0086 0.0176 0.2611
Plasmodium falciparum thioredoxin reductase 0.0035 0.0052 0.2399
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0098 0.0206 0.0217
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0153 0.1196
Schistosoma mansoni DNA helicase recq1 0.0023 0.0025 0.0034
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0029 0.0038 0.0034
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0002 0.0011
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0067 0.0065
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0025 0.0929
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0064 0.0758
Onchocerca volvulus 0.0142 0.0313 0.2714
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0082
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0039 0.0037
Loa Loa (eye worm) RNA binding protein 0.0126 0.0275 0.1363
Echinococcus granulosus dna polymerase kappa 0.0045 0.0078 0.0115
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0071 0.0846
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0025 0.1068
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0264
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0001 0.0005
Entamoeba histolytica acyl-CoA synthetase, putative 0.0098 0.0206 0.3054
Echinococcus multilocularis cyclin dependent kinase 5 0.0086 0.0176 0.0174
Trypanosoma cruzi cdc2-related kinase 3 0.0086 0.0176 0.2117
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.067 0.342
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0001 0.0007
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0071 0.0105
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0052 0.0155
Echinococcus multilocularis geminin 0.1185 0.2846 0.2844
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1208 0.6161
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0841 0.201 0.3041
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0253 0.0583 0.1729
Toxoplasma gondii thioredoxin reductase 0.01 0.0211 0.8697
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0098 0.0206 0.1017
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0141 0.021
Schistosoma mansoni alpha-glucosidase 0.0142 0.0313 0.0472
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0086 0.0176 0.0264
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0275 0.1363
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0039 0.0037
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0264
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0054 0.0278
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0141 0.0428
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0781 0.3987
Echinococcus multilocularis cyclin dependent kinase 1 0.0086 0.0176 0.0174
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0505 0.1195 0.1807
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.0211 0.0209
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0153 0.6266
Loa Loa (eye worm) hypothetical protein 0.078 0.1862 0.9264
Loa Loa (eye worm) fli-1 protein 0.0257 0.0593 0.2944
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0038 0.0194
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0206 0.1021
Entamoeba histolytica acyl-coA synthetase, putative 0.0098 0.0206 0.3054
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.0239 0.0359
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0071 0.0363
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0052 0.2399
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0228 0.0521 0.0561
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0064 0.2954
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0027 0.0314
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0323 0.0752 0.3738
Mycobacterium ulcerans transcriptional regulator 0.1346 0.3236 1
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0014 0.0002 0.0007
Schistosoma mansoni smad 0.0016 0.0007 0.0008
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0025 0.0028 0.0134
Treponema pallidum fructose-bisphosphate aldolase 0.0289 0.067 0.6464
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0006 0.0004
Toxoplasma gondii hypothetical protein 0.0057 0.0107 0.4353
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0052 0.0617
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0011 0.0014
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.0369 0.0556
Brugia malayi CXXC zinc finger family protein 0.0097 0.0203 0.101
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0029 0.0038 0.011
Trypanosoma brucei unspecified product 0.0045 0.0078 0.0928
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0142 0.0313 0.0472
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0089 0.0132
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0142 0.0313 0.0334
Schistosoma mansoni hypothetical protein 0.0097 0.0203 0.0305
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0054 0.0643
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0052 0.0179
Echinococcus granulosus tar DNA binding protein 0.0126 0.0275 0.0414
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0011 0.0048
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1346 0.3236 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0021 0.0095
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0044 0.0515
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0006 0.006
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0275 0.0414
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0026 0.0132
Onchocerca volvulus Alhambra homolog 0.0029 0.0039 0.0328
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0188
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0029 0.0038 0.1711
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0153 0.7205
Loa Loa (eye worm) hypothetical protein 0.0177 0.0397 0.1972
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0012 0.0015
Brugia malayi Probable ClpP-like protease 0.0076 0.0153 0.0756
Loa Loa (eye worm) acetylcholinesterase 1 0.0841 0.201 1
Schistosoma mansoni hypothetical protein 0.0104 0.0221 0.0331
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0025 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0011 0.0053
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0038 0.0182
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0099 0.0209 0.9897
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0071 0.0352
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.003 0.0147
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0025 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1208 0.6161
Trichomonas vaginalis spcc417.12 protein, putative 0.0142 0.0313 0.1598
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0781 0.3987
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0071 0.1043
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0012 0.0015
Mycobacterium ulcerans lipase LipD 0.0036 0.0054 0.0161
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0086 0.0176 0.0869
Brugia malayi Carboxylesterase family protein 0.0142 0.0313 0.1556
Schistosoma mansoni terminal deoxycytidyl transferase 0.0045 0.0078 0.0115
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0045 0.0078 0.0381
Loa Loa (eye worm) STAT protein 0.016 0.0357 0.1769
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0011 0.0014
Brugia malayi Disco-interacting protein 2 homolog 0.0045 0.0078 0.0384
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0006 0.0193
Brugia malayi isocitrate dehydrogenase 0.0016 0.0006 0.0029
Brugia malayi MH1 domain containing protein 0.0016 0.0007 0.0034
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0042 0.007 0.0068
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0112 0.0167
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0078 0.0928
Entamoeba histolytica hypothetical protein 0.0185 0.0418 0.6235
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Mycobacterium ulcerans acetyl-CoA synthetase 0.0029 0.0038 0.011
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0027 0.0023
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0004
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0052 0.0617
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0038 0.0186
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0025 0.0333
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0044 0.0515
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0023 0.0024 0.1059
Trypanosoma brucei trypanothione reductase 0.01 0.0211 0.2539
Echinococcus multilocularis microtubule associated protein 2 0.2734 0.6605 0.6604
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0045 0.0078 0.0115
Brugia malayi Matrixin family protein 0.0049 0.0088 0.0435
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0123 0.0121
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0085 0.0174 0.0859
Brugia malayi MH2 domain containing protein 0.0016 0.0007 0.0034
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0052 0.0155
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0323 0.0752 0.1136
Brugia malayi Carboxylesterase family protein 0.0142 0.0313 0.1556
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0006 0.006
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0292
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0211 0.1046
Brugia malayi Fli-1 protein 0.0257 0.0593 0.2947
Onchocerca volvulus Matrix metalloproteinase homolog 0.0045 0.0078 0.0667
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0057 0.0278
Schistosoma mansoni hypothetical protein 0.0097 0.0203 0.0305
Mycobacterium tuberculosis Probable dehydrogenase 0.0228 0.0521 0.0561
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0011 0.0014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0052 0.0617
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0011 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0011 0.0048
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0111 0.0239 0.2878
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0048
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0011 0.0014
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0034
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0142 0.0313 0.1598
Mycobacterium ulcerans hypothetical protein 0.0098 0.0206 0.0629
Loa Loa (eye worm) hypothetical protein 0.0104 0.0221 0.1091
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0021 0.0232
Brugia malayi MH2 domain containing protein 0.0236 0.0542 0.2695
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0123 0.0183
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0054 0.0052
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0029 0.0038 0.0034
Loa Loa (eye worm) Smad1 0.0016 0.0007 0.003
Echinococcus multilocularis cyclin dependent kinase 0.0086 0.0176 0.0174
Mycobacterium ulcerans carboxylesterase, LipT 0.0142 0.0313 0.0962
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0025 0.0281
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0781 0.3987
Loa Loa (eye worm) carboxylesterase 0.0841 0.201 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0035 0.1351
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.0211 0.0316
Trypanosoma cruzi cdc2-related kinase 3 0.0086 0.0176 0.2117
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0781 0.3987
Toxoplasma gondii propionate-CoA ligase 0.0029 0.0038 0.1488
Echinococcus granulosus cyclin dependent kinase 1 0.0086 0.0176 0.0264
Loa Loa (eye worm) hypothetical protein 0.0084 0.0173 0.0854
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0337 0.1672
Brugia malayi RNA binding protein 0.0126 0.0275 0.1367
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0089 0.1061
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0029 0.0038 0.011
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0035 0.003
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0121 0.0262 0.2306
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0064 0.019
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.02 0.0198
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0014 0.0002 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0085 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0123 0.0183
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0002 0.0011
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0052 0.0617
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0029 0.0038 0.0186
Brugia malayi Ets-domain containing protein 0.0085 0.0174 0.0863
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0039 0.1543
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0039 0.0459
Schistosoma mansoni glutaminase 0.082 0.196 0.2965
Brugia malayi MH1 domain containing protein 0.0016 0.0007 0.0034
Leishmania major trypanothione reductase 0.01 0.0211 0.2539
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0078 0.0234
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0167 0.0374 0.4521
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0057 0.0084
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0057 0.0055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0098 0.0206 0.0217
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0206 0.2477
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0057 0.0292
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0023 0.0024 0.0022
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0052 0.0617
Leishmania major DNA polymerase eta, putative 0.0044 0.0075 0.0888
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0078 0.0385
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0039 0.0459
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0043 0.021
Schistosoma mansoni acetyl-CoA synthetase 0.0029 0.0038 0.0055
Echinococcus multilocularis peregrin 0.004 0.0066 0.0064
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0026 0.0132
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0097 0.0203 0.101
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0016 0.0007 0.0005
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0037 0.0059 0.0694
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0021 0.0875
Schistosoma mansoni smad1 5 8 and 0.0016 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0841 0.201 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0142 0.0313 0.0472
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0253 0.0583 0.0628
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0111 0.0165
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0016 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0098 0.0206 0.1017
Giardia lamblia Kinase, CMGC CDK 0.0086 0.0176 0.2601
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0078 0.0928
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0153 0.0386
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0064 0.0326
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0029 0.0038 0.0186
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0136 0.0141
Brugia malayi jmjC domain containing protein 0.0096 0.02 0.0995
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0023 0.0024 0.0921
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0123 0.0183
Trichomonas vaginalis esterase, putative 0.0036 0.0054 0.0278
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0011 0.0014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0085 0.0421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0011 0.0048
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0001 0.0007
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0275 0.0273
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0025 0.0028 0.0402
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.0519 0.0558
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0048
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0073 0.0146 0.1127
Loa Loa (eye worm) hypothetical protein 0.005 0.009 0.044
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0007 0.0005
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0002 0.001
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0089 0.0087
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0039 0.0056
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0153 0.0228
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0089 0.009
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0002 0.0011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.1008 0.5009
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0141 0.0139
Mycobacterium leprae Conserved hypothetical protein 0.1277 0.3068 0.9475
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0029 0.0038 0.0034
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0064 0.0311
Schistosoma mansoni microtubule-associated protein tau 0.2734 0.6605 1
Onchocerca volvulus 0.0142 0.0313 0.2714
Loa Loa (eye worm) glutaminase 0.082 0.196 0.975
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0035 0.1554
Schistosoma mansoni Replicative DNA helicase 0.0433 0.1019 0.1541
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0011 0.0014
Toxoplasma gondii hypothetical protein 0.0099 0.0209 0.8607
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0505 0.1195 0.1807
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0002 0.0011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0011 0.0009
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0098 0.0206 0.0629
Treponema pallidum recombinase A 0.0121 0.0262 0.2329
Echinococcus granulosus L aminoadipate semialdehyde 0.0097 0.0204 0.0307
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0039 0.0056
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0275 0.1363
Echinococcus granulosus cyclin dependent kinase 5 0.0086 0.0176 0.0264
Trypanosoma brucei glucosidase, putative 0.0037 0.0057 0.0677
Plasmodium vivax acyl-CoA synthetase, putative 0.0073 0.0146 0.6876
Onchocerca volvulus 0.0045 0.0078 0.0664
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0136 0.0141
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0019 0.0014 0.0152
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0089 0.0188
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.011
Treponema pallidum replicative DNA helicase (dnaB) 0.0433 0.1019 1
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0035 0.0019
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0052 0.2086
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0142 0.0313 0.0334
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0011 0.0014
Schistosoma mansoni hypothetical protein 0.0041 0.0069 0.0101
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0085 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0002 0.0011
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0097 0.0203 0.0305
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0085 0.0416
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.067 0.342
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0052 0.0617
Trypanosoma cruzi DNA repair protein, putative 0.0037 0.0059 0.0694
Loa Loa (eye worm) hypothetical protein 0.0023 0.0025 0.0115
Onchocerca volvulus 0.0487 0.115 1
Loa Loa (eye worm) hypothetical protein 0.0142 0.0313 0.1553
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0029 0.0038 0.0029
Brugia malayi Ets-domain containing protein 0.0085 0.0174 0.0863
Brugia malayi polk-prov protein 0.0014 0.0002 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0011 0.0048
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0057 0.0282
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0052 0.0617
Echinococcus multilocularis L aminoadipate semialdehyde 0.0097 0.0204 0.0203
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0353
Mycobacterium ulcerans TetR family transcriptional regulator 0.1346 0.3236 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0011 0.0014
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0039 0.1537
Mycobacterium ulcerans recombinase A 0.0121 0.0262 0.0802
Echinococcus multilocularis protein patched 0.0043 0.0072 0.007
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0027 0.0314
Brugia malayi CHE-14 protein 0.0043 0.0072 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0011 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0011 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0098 0.0206 0.0552
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0002 0.001
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0029 0.0038 0.0036
Echinococcus multilocularis GA binding protein alpha chain 0.0085 0.0174 0.0172
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0035 0.0404
Loa Loa (eye worm) hypothetical protein 0.0052 0.0096 0.047
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0097 0.0203 0.0202
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0264
Brugia malayi nuclear receptor NHR-88 0.0018 0.0011 0.0053
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0006 0.006
Trypanosoma brucei DNA polymerase eta, putative 0.0075 0.015 0.1805
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0014 0.0002 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0011 0.0053
Trichomonas vaginalis antibiotic synthetase, putative 0.0029 0.0038 0.0194
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0072 0.0107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.067 0.342
Schistosoma mansoni acetylcholinesterase 0.0142 0.0313 0.0472
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0112 0.0115
Echinococcus multilocularis neuroligin 0.0142 0.0313 0.0311
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0011 0.0009
Schistosoma mansoni alpha-glucosidase 0.0142 0.0313 0.0472
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0086 0.0176 0.0869
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0049 0.0087 0.0129
Onchocerca volvulus 0.0029 0.0038 0.0318
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0011 0.0009
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0029 0.0038 0.0034
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0289 0.067 1
Brugia malayi TAR-binding protein 0.0126 0.0275 0.1367
Echinococcus multilocularis expressed conserved protein 0.0094 0.0196 0.0194
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0111 0.0239 0.0359
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0239 0.1218
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0088 0.0435
Entamoeba histolytica hypothetical protein 0.0185 0.0418 0.6235
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0353 0.0826 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0089 0.009
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0025 0.012
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0001 0.0007
Trypanosoma cruzi polo-like protein kinase, putative 0.0111 0.0239 0.2878
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0064 0.0094
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0038 0.0443
Echinococcus granulosus Smad4 0.0016 0.0007 0.0008
Schistosoma mansoni BC026374 protein (S09 family) 0.0142 0.0313 0.0472
Leishmania major modification methylase-like protein 0.0023 0.0024 0.0278
Giardia lamblia DINP protein human, muc B family 0.0045 0.0078 0.1132
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0025 0.0125
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0011 0.0014
Brugia malayi hypothetical protein 0.0185 0.0418 0.208
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0001 0.0007
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0035 0.01
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0264
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0112 0.0555
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0323 0.0752 0.075
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0086 0.0176 0.2117
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0044 0.0515
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1208 0.6161
Schistosoma mansoni ets-related 0.0257 0.0593 0.0895
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0006 0.0193
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0054 0.0052
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0097 0.0203 0.0305
Schistosoma mansoni hypothetical protein 0.0048 0.0085 0.0126
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0214 0.0322
Schistosoma mansoni transcription factor LCR-F1 0.0185 0.0418 0.0631
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0085 0.0416
Entamoeba histolytica serine/threonine protein kinase, putative 0.0111 0.0239 0.3549
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.0481 0.581
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.0211 0.2539
Brugia malayi Bromodomain containing protein 0.0029 0.0039 0.0192
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0002 0.001
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0074 0.0148 0.0146
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0034
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0023 0.0024 0.0278
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0228 0.0521 0.0561
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0064 0.0315
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0337 0.1676
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0275 0.0414
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0511 0.1208 0.6005
Brugia malayi glutaminase DH11.1 0.082 0.196 0.975
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0038 0.011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0062 0.0091
Brugia malayi Carboxylesterase family protein 0.0142 0.0313 0.1556
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0098 0.0206 0.0552
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0071 0.0846
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0136 0.0141
Loa Loa (eye worm) hypothetical protein 0.0073 0.0146 0.0718
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0011 0.0014
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0052 0.0617
Loa Loa (eye worm) beta-lactamase 0.0036 0.0054 0.0264
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0029 0.0038 0.011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.067 0.342
Echinococcus multilocularis para nitrobenzyl esterase 0.0142 0.0313 0.0311
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0002 0.0011
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0292
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0141 0.0428
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0027 0.0077
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0054 0.0643
Mycobacterium ulcerans beta-lactamase 0.0036 0.0054 0.0161
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0097 0.0203 0.0305
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0034
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0014 0.0002 0.001
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0029 0.0038 0.0034
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0029 0.0038 0.0547
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0002 0.0007
Brugia malayi beta-lactamase family protein 0.0036 0.0054 0.0268
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0064 0.0758
Onchocerca volvulus 0.0098 0.0206 0.1778
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0141 0.021
Onchocerca volvulus 0.0097 0.0203 0.1758
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0086 0.0176 0.2117
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0071 0.0363
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0142 0.0313 0.0472
Plasmodium vivax glutathione reductase, putative 0.01 0.0211 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0011 0.0048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0052 0.0617
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0141 0.0428
Echinococcus granulosus disco interacting protein 2 0.0049 0.0087 0.0129
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0136 0.0141
Toxoplasma gondii exonuclease III APE 0.0039 0.0064 0.2569
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0142 0.0313 0.0311
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0097 0.0203 0.0202
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0239 0.1218
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0038 0.0186
Brugia malayi Pre-SET motif family protein 0.0064 0.0123 0.0608
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0014 0.0002 0.0003
Brugia malayi glutathione reductase 0.01 0.0211 0.1046
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0019 0.0014 0.0018
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0025 0.0028 0.1248
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0052 0.2399
Brugia malayi Matrixin family protein 0.002 0.0018 0.0086
Brugia malayi Matrixin family protein 0.002 0.0018 0.0086
Echinococcus multilocularis cyclin dependent kinase 1 0.0086 0.0176 0.0174
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0035 0.0404
Toxoplasma gondii proteasome regulatory subunit 0.0025 0.0028 0.1085
Loa Loa (eye worm) hypothetical protein 0.0097 0.0204 0.1011
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0089 0.1061
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0239 0.1218
Loa Loa (eye worm) hypothetical protein 0.0098 0.0206 0.1017
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0011 0.0053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0323 0.0752 0.1136
Loa Loa (eye worm) hypothetical protein 0.0076 0.0153 0.0752
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0242 0.0556 0.2759
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0121 0.0262 0.0727
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.067 0.342
Schistosoma mansoni hypothetical protein 0.0041 0.0069 0.0101
Loa Loa (eye worm) oxidoreductase 0.0029 0.0038 0.0182
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0001 0.0007
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0002 0.0007
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0228 0.0521 0.0561
Brugia malayi Muscleblind-like protein 0.078 0.1862 0.9264
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0011 0.0014
Loa Loa (eye worm) matrixin family protein 0.0049 0.0088 0.0431
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0038 0.0186
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0781 0.3987
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.0115 0.1381
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0035 0.1554
Onchocerca volvulus 0.0177 0.0397 0.3447
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0011 0.0053
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0025 0.0125
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0054 0.0052
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0025 0.0023
Trichomonas vaginalis CMGC family protein kinase 0.0086 0.0176 0.0898
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0353 0.0826 1
Brugia malayi ecdysteroid receptor 0.0018 0.0011 0.0053
Schistosoma mansoni DNA polymerase eta 0.0075 0.015 0.0225
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0103 0.0527
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0054 0.0278
Schistosoma mansoni hypothetical protein 0.0479 0.113 0.1708
Schistosoma mansoni cpg binding protein 0.01 0.0211 0.0317
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0029 0.0038 0.0055
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0078 0.0078
Entamoeba histolytica hypothetical protein 0.0185 0.0418 0.6235
Schistosoma mansoni ran 0.0022 0.0021 0.0028
Schistosoma mansoni apoptosis regulator bax 0.0097 0.0203 0.0305
Loa Loa (eye worm) hypothetical protein 0.0042 0.0071 0.0347
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0112 0.134
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0185 0.0418 0.0631
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0007 0.0008
Echinococcus granulosus bloom syndrome protein 0.0023 0.0025 0.0034
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0353 0.0826 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0112 0.0339
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0029
Echinococcus multilocularis acetylcholinesterase 0.0841 0.201 0.2009
Entamoeba histolytica hypothetical protein 0.0027 0.0035 0.0498
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0239 0.1218
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0002 0.0007
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0052 0.2399
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0029 0.0038 0.1488
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0078 0.0928
Brugia malayi STAT protein, DNA binding domain containing protein 0.016 0.0357 0.1772
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0221 0.1095
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0011 0.0084
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0019 0.0014 0.0152
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0052 0.0258
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0086 0.0176 0.7248
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0153 0.0228
Brugia malayi beta-lactamase 0.0036 0.0054 0.0268
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0142 0.0313 0.0472
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0038 0.0443
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0369 0.0367
Entamoeba histolytica hypothetical protein 0.0185 0.0418 0.6235
Toxoplasma gondii hypothetical protein 0.0026 0.0032 0.1228
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0089 0.1061
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0071 0.0069
Entamoeba histolytica deoxycytidyl transferase, putative 0.0045 0.0078 0.1144
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0011 0.0053
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0054 0.0161
Leishmania major hypothetical protein, conserved 0.0036 0.0054 0.0643
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.0369 0.1831
Leishmania major DNA damage repair protein, putative 0.0014 0.0002 0.0011
Loa Loa (eye worm) matrix metalloproteinase 0.002 0.0018 0.0082
Loa Loa (eye worm) proteasome 26S subunit 0.0019 0.0014 0.0062
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0042 0.007 0.0103
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Onchocerca volvulus Matrilysin homolog 0.002 0.0018 0.0143
Echinococcus granulosus cyclin dependent kinase 0.0086 0.0176 0.0264
Loa Loa (eye worm) twinkle helicase 0.0124 0.0269 0.133
Brugia malayi RNA, U transporter 1 0.0083 0.017 0.0844
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0067 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0176 0.0264
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0064 0.0934
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1346 0.3236 0.3518
Onchocerca volvulus 0.0029 0.0038 0.0323
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0027 0.0314
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0075 0.3018
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0021 0.01
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0064 0.0325
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0062 0.0091
Onchocerca volvulus 0.0014 0.0002 0.0005
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0153 0.0151
Brugia malayi Pre-SET motif family protein 0.0428 0.1008 0.5011
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0002 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0292
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0025 0.012
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0057 0.0292
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0071 0.0105
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0025 0.0346
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0141 0.021
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.0726 0.3609
Schistosoma mansoni hypothetical protein 0.0312 0.0726 0.1097
Toxoplasma gondii DNA methyltransferase 2, putative 0.0023 0.0024 0.0921
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0264
Brugia malayi PHD-finger family protein 0.0029 0.0039 0.0192
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0153 0.6266
Loa Loa (eye worm) thioredoxin reductase 0.01 0.0211 0.1042
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0002 0.0011
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0153 0.1223
Leishmania major importin beta-1 subunit, putative 0.0024 0.0026 0.0296
Brugia malayi AMP-binding enzyme family protein 0.0098 0.0206 0.1021
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0025 0.0029 0.0135
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0045 0.0078 0.0076
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0078 0.0398
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0011 0.0009
Schistosoma mansoni SET domain protein 0.0042 0.007 0.0103
Plasmodium falciparum phd finger protein, putative 0.0029 0.0039 0.1768
Plasmodium falciparum importin beta, putative 0.0029 0.0039 0.1774
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0072 0.007
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0021 0.0232
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0078 0.0234
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0054 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0057 0.0677
Loa Loa (eye worm) CXXC zinc finger family protein 0.0097 0.0203 0.1006
Schistosoma mansoni DNA helicase recq5 0.0023 0.0025 0.0034
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.0542 0.2692
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0011 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0011 0.0053
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0019 0.0014 0.0012
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0032 0.1413
Onchocerca volvulus 0.0014 0.0002 0.0005
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0014 0.0002 0.0007
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0038 0.0443
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0112 0.011
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0045 0.0078 0.0115
Plasmodium falciparum thioredoxin reductase 0.01 0.0211 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0021 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0038 0.011
Schistosoma mansoni hypothetical protein 0.0048 0.0085 0.0126
Loa Loa (eye worm) hypothetical protein 0.0045 0.0078 0.038
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0242 1
Echinococcus granulosus geminin 0.1185 0.2846 0.4307
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0039 0.1768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0011 0.0048
Schistosoma mansoni Smad4 0.0016 0.0007 0.0008
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0011 0.0014
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0011 0.0053
Loa Loa (eye worm) hypothetical protein 0.0072 0.0144 0.071
Schistosoma mansoni hypothetical protein 0.0048 0.0085 0.0126
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0292
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3486 0.8429 0.9175
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0054 0.0081
Plasmodium falciparum glutathione reductase 0.01 0.0211 1
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0025 0.0023
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0002 0.001
Echinococcus granulosus expressed conserved protein 0.0094 0.0196 0.0294
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0048
Mycobacterium ulcerans hypothetical protein 0.0186 0.042 0.1292
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0078 0.0078
Echinococcus granulosus para nitrobenzyl esterase 0.0142 0.0313 0.0472
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0275 0.0414
Echinococcus multilocularis muscleblind protein 1 0.078 0.1862 0.1861
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0048
Brugia malayi hypothetical protein 0.0142 0.0313 0.1556
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0781 0.3987
Brugia malayi Carboxylesterase family protein 0.0841 0.201 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0011 0.0053
Toxoplasma gondii ABC1 family protein 0.0036 0.0054 0.2176
Mycobacterium ulcerans hypothetical protein 0.0024 0.0027 0.0077
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0275 0.1367
Schistosoma mansoni hypothetical protein 0.0029 0.0039 0.0056
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0111 0.0239 0.0237
Plasmodium vivax acetyl-CoA synthetase, putative 0.0029 0.0038 0.1711
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0433 0.1019 0.3145
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0002 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0335 0.0781 0.3987
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0511 0.1208 0.6007
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0021 0.0232
Brugia malayi hypothetical protein 0.0242 0.0556 0.2763
Trichomonas vaginalis CMGC family protein kinase 0.0086 0.0176 0.0898
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0023 0.0024 0.0343
Entamoeba histolytica hypothetical protein 0.0024 0.0026 0.0365
Trichomonas vaginalis CAMK family protein kinase 0.0111 0.0239 0.1218
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0007 0.003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0029 0.0038 0.0182
Mycobacterium tuberculosis Conserved protein 0.0036 0.0054 0.0052
Echinococcus multilocularis acetylcholinesterase 0.0841 0.201 0.2009
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0072 0.0369
Plasmodium vivax thioredoxin reductase, putative 0.01 0.0211 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0039 0.1537
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0142 0.0313 0.1553
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0085 0.0083
Giardia lamblia Kinase, PLK 0.0111 0.0239 0.354
Loa Loa (eye worm) hypothetical protein 0.01 0.0211 0.1042
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0001 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0071 0.0363
Onchocerca volvulus 0.0036 0.0056 0.0477
Trypanosoma brucei hypothetical protein, conserved 0.0211 0.0481 0.581
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0103 0.0527
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0097 0.0204 0.0307
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.002 0.0028
Chlamydia trachomatis recombinase RecA 0.0121 0.0262 0.2306
Schistosoma mansoni coup transcription factor 0.0018 0.0011 0.0014
Brugia malayi Smad1 0.0016 0.0007 0.0034
Schistosoma mansoni hypothetical protein 0.0048 0.0085 0.0126
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0011 0.0084
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0064 0.0758
Brugia malayi hypothetical protein 0.0242 0.0555 0.2757
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0057 0.0835
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0086 0.0176 0.0869
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0264
Loa Loa (eye worm) hypothetical protein 0.0073 0.0146 0.0718
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0085 0.0421
Schistosoma mansoni importin beta-1 0.0029 0.0039 0.0057
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3798 0.9187 1
Onchocerca volvulus 0.0018 0.0011 0.0084
Leishmania major DNA polymerase eta, putative 0.0075 0.015 0.1805
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0029 0.0038 0.0443
Loa Loa (eye worm) hypothetical protein 0.0073 0.0146 0.0718
Onchocerca volvulus 0.0029 0.0038 0.0318
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0153 0.7205
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0021 0.0875
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0035 0.01
Schistosoma mansoni hypothetical protein 0.0097 0.0203 0.0305
Chlamydia trachomatis replicative DNA helicase 0.0433 0.1019 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0002 0.0011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0185 0.0418 0.0417
Echinococcus granulosus dnaJ subfamily B 0.0479 0.113 0.1708
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0025 0.0028 0.0138
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0023 0.0024 0.0034
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0006 0.0029
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0078 0.0076
Brugia malayi Carboxylesterase family protein 0.0142 0.0313 0.1556
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0029 0.0038 0.011
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0011 0.0048
Schistosoma mansoni hypothetical protein 0.1185 0.2846 0.4307
Mycobacterium leprae Probable lipase LipE 0.0036 0.0054 0.0081
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0023 0.0024 0.1059
Brugia malayi G-protein alpha subunit 0.0014 0.0002 0.0007
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0011 0.0014
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0072 0.0353
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0123 0.0183
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0323 0.0752 0.374
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0052 0.0617
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0011 0.0053
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0032 0.001
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0029 0.0038 0.0034
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0054 0.0278
Echinococcus granulosus dna polymerase eta 0.0075 0.015 0.0225
Trypanosoma brucei polo-like protein kinase 0.0111 0.0239 0.2878
Brugia malayi jmjC domain containing protein 0.0039 0.0062 0.0306
Leishmania major acetyl-CoA synthetase, putative 0.0029 0.0038 0.0443
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0064 0.0296
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0052 0.0179
Brugia malayi Importin beta-1 subunit 0.0029 0.0039 0.0193
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0189
Loa Loa (eye worm) hypothetical protein 0.0097 0.0203 0.1006
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.0555 0.0837
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0011 0.0014
Trichomonas vaginalis ran, putative 0.0022 0.0021 0.0105
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0054 0.0268
Echinococcus granulosus smad 0.0016 0.0007 0.0008
Trypanosoma cruzi polo-like protein kinase, putative 0.0111 0.0239 0.2878
Echinococcus granulosus BC026374 protein S09 family 0.0142 0.0313 0.0472
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0206 0.0629
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0006 0.006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0337 0.1676
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0071 0.0105
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0021 0.0761
Schistosoma mansoni hypothetical protein 0.0029 0.0038 0.0055
Schistosoma mansoni gliotactin 0.0142 0.0313 0.0472
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0323 0.0752 0.1136
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0167 0.0374 0.4521
Trichomonas vaginalis glucosylceramidase, putative 0.0511 0.1208 0.6161
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0323 0.0752 0.1136
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0014 0.0002 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0038 0.0034
Loa Loa (eye worm) apoptosis regulator protein 0.0097 0.0203 0.1006
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.0542 0.2692
Mycobacterium ulcerans acyl-CoA synthetase 0.0098 0.0206 0.0629
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0323 0.0752 0.1136
Schistosoma mansoni hypothetical protein 0.1185 0.2846 0.4307
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0028 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0011 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0011 0.0009
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0014 0.0002 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0323 0.0752 0.075
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0141 0.0146
Brugia malayi hypothetical protein 0.0177 0.0397 0.1975
Plasmodium falciparum glutathione reductase 0.0035 0.0052 0.2399
Loa Loa (eye worm) G protein alpha subunit 3 0.0014 0.0002 0.0003
Echinococcus multilocularis BC026374 protein (S09 family) 0.0142 0.0313 0.0311
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0071 0.0069
Schistosoma mansoni hypothetical protein 0.0049 0.0088 0.013
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0505 0.1195 0.5944
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0029 0.0038 0.1488
Schistosoma mansoni hypothetical protein 0.0041 0.0069 0.0101
Brugia malayi Matrixin family protein 0.002 0.0018 0.0086
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0074 0.0148 0.0222
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.003 0.0147
Mycobacterium ulcerans hydrolase 0.0025 0.0029 0.0081
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0001 0.0007
Echinococcus multilocularis carboxylesterase 5A 0.0841 0.201 0.2009
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0001 0.0007
Treponema pallidum NADH oxidase 0.0035 0.0052 0.0208
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0035 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.0825 0.421
Brugia malayi Carboxylesterase family protein 0.0841 0.201 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0025 0.0034
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0311 0.0955
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0038 0.0029
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0054 0.0278
Loa Loa (eye worm) histone methyltransferase 0.0021 0.002 0.0093
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0123 0.0183
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0078 0.0928
Brugia malayi cell division control protein 2 homolog 0.0086 0.0176 0.0873
Entamoeba histolytica cell division protein kinase 2, putative 0.0086 0.0176 0.2611
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0064 0.0063
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0841 0.201 1
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0019 0.0014 0.0152
Leishmania major 4-coumarate:coa ligase-like protein 0.0098 0.0206 0.2477
Leishmania major mitochondrial DNA polymerase beta 0.0353 0.0826 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0289 0.067 0.342
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0433 0.1019 0.3089
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0057 0.0292
Trichomonas vaginalis CMGC family protein kinase 0.0086 0.0176 0.0898
Loa Loa (eye worm) hypothetical protein 0.0242 0.0555 0.2754
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0433 0.1019 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0141 0.1689
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0054 0.0264
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0025 0.0028 0.1248
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0078 0.0928
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0052 0.005
Mycobacterium ulcerans glutaminase 0.082 0.196 0.6054
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0112 0.0167
Echinococcus granulosus microtubule associated protein 2 0.2734 0.6605 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0035 0.0031
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0014 0.0002 0.0003
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1346 0.3236 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0071 0.0069
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0006 0.0168
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0052 0.0076

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antiemphysema activity in wild type mouse assessed as reduction in intranasal elastase-induced lung volume at 30 mg/kg, ip qd for 28 days measured after 18 hrs of post mortem by volume displacement technique relative to vehicle-treated control ChEMBL. 21983441
Activity (functional) Antiemphysema activity in wild type mouse assessed as reduction in intranasal elastase-induced lung compliance at 30 mg/kg, ip qd for 28 days by flexivent relative to vehicle-treated control ChEMBL. 21983441
Activity (functional) Effect on intransal elastase-induced LTB4 level in broncho alveolar lavage fluid in ip dosed mouse by ELISA (Rvb = 93.1 +/- 26.1 pg/mL) ChEMBL. 21983441
Activity (functional) Antiemphysema activity in wild type mouse assessed as shorter chord length at 30 mg/kg, ip qd for 28 days measured after 18 hrs of post mortem by volume displacement technique relative to vehicle-treated control ChEMBL. 21983441
Activity (binding) = 50 uM Activation of aminopeptidase activity of LTA4H assessed as compound concentration required to 50% activation using L-alanine-p-nitroanilide as substrate by spectrophotometry ChEMBL. 21983441

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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