Detailed information for compound 1588318

Basic information

Technical information
  • TDR Targets ID: 1588318
  • Name: N-cyclohexyl-3-[(4-methylbenzoyl)amino]benzam ide
  • MW: 336.427 | Formula: C21H24N2O2
  • H donors: 2 H acceptors: 2 LogP: 4.21 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)C(=O)Nc1cccc(c1)C(=O)NC1CCCCC1
  • InChi: 1S/C21H24N2O2/c1-15-10-12-16(13-11-15)20(24)23-19-9-5-6-17(14-19)21(25)22-18-7-3-2-4-8-18/h5-6,9-14,18H,2-4,7-8H2,1H3,(H,22,25)(H,23,24)
  • InChiKey: RKUKTLFVBOCIGM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-cyclohexyl-3-[[(4-methylphenyl)-oxomethyl]amino]benzamide
  • N-cyclohexyl-3-[(4-methylphenyl)carbonylamino]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus expressed protein 0.0077 0.0386 0.0774
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0122 0.0893 0.3362
Schistosoma mansoni serine/threonine protein kinase 0.025 0.2311 0.4819
Trichomonas vaginalis AGC family protein kinase 0.0277 0.261 1
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0187 0.1614 0.1614
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.006 0.0204 0.0204
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0102 0.0672 0.0672
Schistosoma mansoni tyrosine kinase 0.0127 0.0947 0.1974
Echinococcus granulosus serine:threonine protein kinase 3 0.0252 0.2331 0.4671
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0204 0.0426
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0068 0.029 0.0605
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.015 0.1204 0.1204
Echinococcus granulosus serine:threonine protein kinase N2 0.0279 0.263 0.5271
Brugia malayi Immunoglobulin I-set domain containing protein 0.0402 0.3985 0.3985
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0363 0.3562 0.7137
Echinococcus granulosus fibroblast growth factor receptor 4 0.0126 0.0939 0.1882
Trichomonas vaginalis AGC family protein kinase 0.0148 0.1179 0.4468
Plasmodium vivax glycogen synthase kinase 3, putative 0.0123 0.0896 0.736
Trichomonas vaginalis AGC family protein kinase 0.0277 0.261 1
Loa Loa (eye worm) SRC-1 0.0127 0.0947 0.0947
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.013 0.098 0.8066
Brugia malayi protein-tyrosine kinase 0.0108 0.074 0.074
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0455 0.1667
Trypanosoma cruzi Protein kinase B 0.0155 0.1256 1
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0368 0.0768
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0123 0.0896 0.3436
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0113 0.0786 0.0786
Echinococcus granulosus protein kinase c iota type 0.0266 0.249 0.499
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0577 0.2138
Loa Loa (eye worm) AGC/PKA protein kinase 0.0066 0.0273 0.0273
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0391 0.3869 0.7753
Entamoeba histolytica cell division protein kinase 2, putative 0.0113 0.0786 0.2948
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0094 0.0585 0.1172
Brugia malayi Protein kinase domain containing protein 0.0049 0.0084 0.0084
Echinococcus multilocularis mitogen activated protein kinase 3 0.0077 0.0393 0.0788
Echinococcus granulosus tyrosine protein kinase Fyn 0.0127 0.0947 0.1897
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0084 0.0084
Giardia lamblia Kinase, CK1 Casein kinase 0.0102 0.0672 0.5471
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0113 0.0786 0.3001
Echinococcus multilocularis N chimaerin 0.0058 0.0177 0.0354
Brugia malayi Doublecortin family protein 0.0145 0.1144 0.1144
Brugia malayi Protein kinase domain 0.0079 0.0419 0.0419
Brugia malayi Protein kinase domain containing protein 0.0148 0.1179 0.1179
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0158 0.1293 0.2591
Entamoeba histolytica protein kinase, putative 0.0277 0.261 1
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.202 0.4213
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0125 0.0924 0.1851
Entamoeba histolytica protein kinase, putative 0.0077 0.0386 0.1402
Echinococcus granulosus serine:threonine protein kinase 0.0108 0.0734 0.147
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0258 0.2396 0.4801
Echinococcus granulosus tyrosine protein kinase Fyn 0.0127 0.0947 0.1897
Brugia malayi SH2 domain containing protein 0.0049 0.0084 0.0084
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0116 0.0824 0.0824
Brugia malayi Protein kinase domain containing protein 0.0187 0.1614 0.1614
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Trypanosoma cruzi casein kinase II, putative 0.0094 0.0577 0.4489
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0075 0.0368 0.0368
Brugia malayi Protein kinase domain containing protein 0.0148 0.1176 0.1176
Trypanosoma cruzi casein kinase, putative 0.0102 0.0672 0.5266
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0048 0.0068 0.017
Brugia malayi Immunoglobulin I-set domain containing protein 0.014 0.1093 0.1093
Loa Loa (eye worm) hypothetical protein 0.0258 0.2396 0.2396
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.026 0.2414 0.2414
Toxoplasma gondii AGC kinase 0.0066 0.0273 0.0982
Loa Loa (eye worm) hypothetical protein 0.0117 0.0836 0.0836
Onchocerca volvulus Serine\/threonine kinase homolog 0.0074 0.0362 0.0997
Trypanosoma brucei casein kinase I, isoform 2 0.0102 0.0672 0.2508
Schistosoma mansoni ephrin receptor 0.0042 0.0005 0.001
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0139 0.1076 0.2156
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0273 0.057
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0088 0.0509 0.0509
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0151 0.1209 1
Schistosoma mansoni cell adhesion molecule 0.0075 0.0375 0.0782
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0151 0.0151
Trypanosoma brucei cdc2-related kinase 1 0.0113 0.0786 0.2948
Trypanosoma cruzi aurora B kinase, putative 0.0083 0.0455 0.3499
Trypanosoma brucei protein kinase, putative 0.0052 0.0115 0.0354
Echinococcus multilocularis tyrosine kinase 0.0049 0.0084 0.0168
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0786 0.1639
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0113 0.079 0.1648
Echinococcus granulosus tyrosine protein kinase ABL1 0.0049 0.0084 0.0168
Trichomonas vaginalis AGC family protein kinase 0.0148 0.1179 0.4468
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0896 0.3375
Schistosoma mansoni protein kinase 0.0094 0.0577 0.1203
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0048 0.0068 0.0357
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.1179 0.2459
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0143 0.1122 0.1122
Echinococcus multilocularis epidermal growth factor receptor 0.0166 0.1381 0.2767
Echinococcus multilocularis protein kinase c iota type 0.0266 0.249 0.499
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0068 0.0141
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0362 0.1308
Giardia lamblia Kinase, CAMK CAMKL 0.006 0.0204 0.1521
Onchocerca volvulus 0.0049 0.0084 0.0194
Trypanosoma cruzi cdc2-related kinase 3 0.0113 0.0786 0.6188
Leishmania major protein kinase, putative 0.0148 0.1176 0.9494
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0066 0.0273 0.0964
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0077 0.0393 0.3
Echinococcus multilocularis dual specificity 0.0079 0.0418 0.0839
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0393 0.1429
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0258 0.2396 0.4801
Onchocerca volvulus Tyrosine kinase homolog 0.0356 0.3479 1
Schistosoma mansoni protein kinase 0.0147 0.117 0.2441
Echinococcus granulosus serine:threonine protein kinase N2 0.0131 0.0991 0.1985
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0113 0.079 0.1583
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0204 0.0426
Schistosoma mansoni hypothetical protein 0.0258 0.2396 0.4996
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0113 0.0786 0.6281
Trypanosoma cruzi cdc2-related kinase 1 0.0113 0.0786 0.6188
Entamoeba histolytica protein kinase, putative 0.0075 0.0368 0.1332
Entamoeba histolytica protein kinase, putative 0.0083 0.0455 0.1667
Echinococcus multilocularis serine:threonine protein kinase N2 0.0279 0.263 0.5271
Giardia lamblia Kinase, CMGC CDK 0.0113 0.0786 0.6429
Toxoplasma gondii histone kinase SNF1, putative 0.006 0.0204 0.071
Echinococcus granulosus N chimaerin 0.0058 0.0177 0.0354
Brugia malayi MAP kinase sur-1 0.0077 0.0393 0.0393
Giardia lamblia Kinase, AGC PKA 0.0151 0.1209 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0273 0.2563 0.2563
Trypanosoma brucei protein kinase, putative 0.0123 0.0896 0.3375
Trichomonas vaginalis CMGC family protein kinase 0.0148 0.1176 0.4456
Brugia malayi Protein kinase domain containing protein 0.0049 0.0084 0.0084
Brugia malayi Protein kinase domain containing protein 0.0049 0.0084 0.0084
Echinococcus granulosus CDC7 cell division cycle 7 0.0083 0.0461 0.0924
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0258 0.2396 0.4801
Echinococcus multilocularis CDC7 cell division cycle 7 0.0083 0.0461 0.0924
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0068 0.029 0.0582
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0349 0.3403 0.9781
Schistosoma mansoni tyrosine kinase 0.0166 0.1381 0.2879
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0195 0.1703 0.1703
Loa Loa (eye worm) TK/EPH protein kinase 0.0109 0.0743 0.0743
Loa Loa (eye worm) hypothetical protein 0.0083 0.0453 0.0453
Entamoeba histolytica casein kinase 1, putative 0.0102 0.0672 0.2508
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0113 0.079 0.2963
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0066 0.0273 0.0964
Echinococcus granulosus dual specificity protein kinase clk2 0.0148 0.1176 0.2357
Echinococcus granulosus cyclin dependent kinase 5 0.0113 0.0786 0.1575
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0148 0.1176 0.9354
Leishmania major casein kinase, putative 0.0102 0.0672 0.5345
Trypanosoma cruzi casein kinase, putative 0.0102 0.0672 0.5266
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0224 0.202 0.4048
Echinococcus granulosus c-Jun N-terminal kinases 0.026 0.2414 0.4838
Echinococcus granulosus tyrosine protein kinase 0.0269 0.2513 0.5037
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0393 0.1429
Brugia malayi SH2 domain containing protein 0.0049 0.0084 0.0084
Schistosoma mansoni protein kinase 0.0083 0.0455 0.0949
Schistosoma mansoni tyrosine kinase 0.0051 0.0103 0.0214
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0945 1 1
Trichomonas vaginalis STE family protein kinase 0.0079 0.0419 0.1528
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.006 0.0204 0.0204
Entamoeba histolytica protein kinase, putative 0.0058 0.0176 0.0589
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0094 0.0585 0.1172
Schistosoma mansoni serine/threonine protein kinase 0.0349 0.3403 0.7096
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0151 0.0315
Plasmodium falciparum protein serine/threonine kinase-1 0.0148 0.1176 0.9718
Giardia lamblia Kinase, NEK 0.013 0.098 0.8066
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0418 0.0873
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0418 0.1526
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0166 0.1381 0.2767
Trypanosoma cruzi casein kinase, putative 0.0102 0.0672 0.5266
Schistosoma mansoni serine/threonine protein kinase 0.0391 0.3869 0.8068
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0066 0.0273 0.0547
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0049 0.0079 0.0214
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0113 0.079 0.079
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0079 0.0419 0.084
Brugia malayi Protein kinase domain containing protein 0.0108 0.0734 0.0734
Giardia lamblia Kinase, CMGC GSK 0.0123 0.0896 0.736
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0049 0.008 0.0167
Echinococcus granulosus tyrosine protein kinase Src42A 0.0084 0.0472 0.0946
Echinococcus multilocularis casein kinase I alpha 0.0102 0.0672 0.1348
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0319 0.1143
Brugia malayi Protein kinase domain containing protein 0.0208 0.1843 0.1843
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0402 0.3985 0.3985
Echinococcus granulosus tyrosine protein kinase Blk 0.0108 0.074 0.1483
Echinococcus granulosus mitogen activated protein kinase 11 0.0153 0.1237 0.248
Echinococcus multilocularis serine:threonine protein kinase 38 0.0148 0.1179 0.2363
Echinococcus multilocularis tyrosine protein kinase HCK 0.0085 0.0486 0.0974
Brugia malayi RhoGAP domain containing protein 0.0058 0.0177 0.0177
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0393 0.082
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0197 0.1724 0.3455
Plasmodium vivax unspecified product 0.0094 0.0577 0.4664
Entamoeba histolytica hypothetical protein 0.0116 0.0824 0.3096
Echinococcus granulosus tyrosine protein kinase HCK 0.0085 0.0486 0.0974
Brugia malayi Fibronectin type III domain containing protein 0.0065 0.0256 0.0256
Schistosoma mansoni atypical protein kinase C 0.0273 0.2558 0.5335
Trichomonas vaginalis STE family protein kinase 0.013 0.098 0.3698
Plasmodium falciparum serine/threonine protein kinase KIN 0.006 0.0204 0.1521
Brugia malayi casein kinase 1, delta 0.0102 0.0672 0.0672
Echinococcus granulosus titin 0.0056 0.0154 0.0309
Echinococcus granulosus casein kinase I delta 0.0102 0.0672 0.1348
Trypanosoma cruzi polo-like protein kinase, putative 0.0074 0.0362 0.2745
Loa Loa (eye worm) hypothetical protein 0.0049 0.008 0.008
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0094 0.0585 0.2209
Echinococcus granulosus insulin receptor 0.0206 0.1819 0.3644
Echinococcus multilocularis casein kinase I delta 0.0102 0.0672 0.1348
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0349 0.3403 0.3403
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0151 0.0302
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0349 0.3403 0.3403
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.1176 0.2452
Echinococcus granulosus casein kinase I alpha 0.0102 0.0672 0.1348
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0083 0.0455 0.1667
Plasmodium vivax casein kinase 1, putative 0.0102 0.0672 0.5471
Onchocerca volvulus 0.0049 0.0084 0.0194
Loa Loa (eye worm) AGC/PKA protein kinase 0.0066 0.0273 0.0273
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0393 0.1429
Echinococcus granulosus NDR protein kinase 0.0148 0.1179 0.2363
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0145 0.1144 0.1144
Trichomonas vaginalis AGC family protein kinase 0.0277 0.261 1
Brugia malayi P38 map kinase family protein 2 0.0153 0.1237 0.1237
Plasmodium falciparum calcium-dependent protein kinase 1 0.0094 0.0585 0.4733
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.017 0.1418 0.2841
Brugia malayi Protein kinase domain containing protein 0.0083 0.0461 0.0461
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0077 0.0386 0.2943
Echinococcus granulosus nervana 2 0.0125 0.0924 0.1851
Onchocerca volvulus 0.0121 0.0882 0.25
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.1576 0.3287
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0153 0.1237 0.1237
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0126 0.0939 0.1882
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0148 0.1176 0.9354
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0075 0.0368 0.0738
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0509 0.1062
Loa Loa (eye worm) CDC7 protein kinase 0.0083 0.0461 0.0461
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0068 0.0141
Echinococcus granulosus tyrosine protein kinase Lyn 0.0153 0.1233 0.247
Schistosoma mansoni protein kinase 0.0363 0.3562 0.7427
Schistosoma mansoni hypothetical protein 0.0258 0.2396 0.4996
Brugia malayi protein kinase C3,putative 0.0144 0.1136 0.1136
Schistosoma mansoni growth factor receptor-bound protein 0.0044 0.0022 0.0047
Trichomonas vaginalis STE family protein kinase 0.0058 0.0176 0.0589
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0127 0.0947 0.1897
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.006 0.0204 0.1486
Schistosoma mansoni protein kinase 0.0431 0.4313 0.8995
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0066 0.0273 0.0547
Echinococcus multilocularis casein kinase I alpha 0.0102 0.0672 0.1348
Loa Loa (eye worm) hypothetical protein 0.0049 0.0084 0.0084
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Brugia malayi Protein kinase domain containing protein 0.0113 0.0786 0.0786
Plasmodium falciparum NIMA related kinase 1 0.013 0.098 0.8066
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0148 0.1176 0.9354
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0148 0.1176 0.4456
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.0786 0.2948
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0127 0.0947 0.1897
Echinococcus multilocularis ephrin type A receptor 4 A 0.0091 0.0546 0.1094
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0084 0.0084
Echinococcus multilocularis dual specificity 0.0079 0.0418 0.0839
Plasmodium vivax serine/threonine kinase-1, putative 0.0148 0.1176 0.9718
Onchocerca volvulus 0.0321 0.3096 0.8894
Brugia malayi Protein kinase domain containing protein 0.0158 0.1293 0.1293
Echinococcus multilocularis activin receptor type 0.0052 0.0115 0.0231
Echinococcus multilocularis Immunoglobulin 0.0049 0.008 0.0161
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0197 0.1724 0.3455
Trypanosoma cruzi polo-like protein kinase, putative 0.0074 0.0362 0.2745
Leishmania major protein kinase, putative 0.0094 0.0585 0.4624
Echinococcus multilocularis cyclin dependent kinase 1 0.0113 0.0786 0.1575
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0058 0.0177 0.0368
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0066 0.0273 0.0547
Echinococcus multilocularis hypothetical protein 0.0062 0.0224 0.0448
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.1179 0.2459
Plasmodium falciparum calcium-dependent protein kinase 3 0.0094 0.0585 0.4733
Giardia lamblia Kinase, AGC AKT 0.0111 0.0767 0.6265
Trypanosoma cruzi casein kinase, putative 0.0102 0.0672 0.5266
Loa Loa (eye worm) hypothetical protein 0.0074 0.0354 0.0354
Brugia malayi hypothetical protein 0.0217 0.1943 0.1943
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0049 0.0084 0.0231
Schistosoma mansoni serine/threonine-protein kinase 0.0155 0.1256 0.2618
Plasmodium vivax calcium-dependent protein kinase, putative 0.0094 0.0585 0.4733
Entamoeba histolytica serine/threonine protein kinase, putative 0.006 0.0204 0.0697
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0492 0.499 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0127 0.0947 0.1897
Loa Loa (eye worm) hypothetical protein 0.014 0.1093 0.1093
Schistosoma mansoni tyrosine kinase 0.014 0.109 0.2274
Loa Loa (eye worm) hypothetical protein 0.0046 0.0052 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0321 0.3096 0.6456
Echinococcus granulosus tyrosine kinase 0.0108 0.074 0.1483
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0233 0.2121 0.2121
Brugia malayi map kinase activated protein kinase protein 2 0.0391 0.3869 0.3869
Echinococcus multilocularis serine:threonine kinase SAD 1 0.006 0.0204 0.0409
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0074 0.0363 0.1335
Brugia malayi Protein kinase domain containing protein 0.0446 0.4477 0.4477
Echinococcus granulosus protein kinase C gamma type 0.0189 0.1637 0.3281
Echinococcus multilocularis casein kinase i 0.0102 0.0672 0.1348
Trypanosoma cruzi cdc2-related kinase 3 0.0113 0.0786 0.6188
Plasmodium vivax protein kinase Crk2 0.0113 0.0786 0.6429
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0455 0.1667
Onchocerca volvulus 0.0056 0.0154 0.0397
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0094 0.0585 0.1172
Trypanosoma brucei rac serine-threonine kinase, putative 0.0277 0.261 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.0153 0.1237 0.248
Echinococcus multilocularis dual specificity 0.0116 0.0824 0.1652
Echinococcus multilocularis dual specificity 0.0079 0.0418 0.0839
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0094 0.0585 0.1172
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0094 0.0577 0.4664
Schistosoma mansoni protein kinase 0.0052 0.0115 0.024
Echinococcus granulosus serine:threonine protein kinase MARK2 0.017 0.1418 0.2841
Echinococcus multilocularis mitogen activated protein kinase 11 0.0153 0.1237 0.248
Echinococcus granulosus protein kinase c epsilon type 0.0184 0.1576 0.3159
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0222 0.1994 0.3996
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0113 0.0786 0.0786
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0151 0.0315
Giardia lamblia Kinase, NEK 0.013 0.098 0.8066
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0585 0.122
Brugia malayi Temporarily assigned gene name protein 59 0.013 0.0983 0.0983
Plasmodium falciparum calcium-dependent protein kinase 2 0.0094 0.0585 0.4733
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0154 0.0321
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0158 0.1293 0.2591
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0108 0.074 0.1483
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0127 0.0947 0.1897
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0585 0.217
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0079 0.0418 0.3252
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0337 0.3268 0.3268
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0509 0.1062
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0074 0.0362 0.0362
Schistosoma mansoni tyrosine kinase 0.014 0.109 0.2274
Loa Loa (eye worm) hypothetical protein 0.0066 0.0273 0.0273
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0067 0.0283 0.0283
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0418 0.1526
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0273 0.0964
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0066 0.0273 0.2024
Echinococcus multilocularis dual specificity protein kinase clk2 0.0148 0.1176 0.2357
Loa Loa (eye worm) hypothetical protein 0.0094 0.0585 0.0585
Trypanosoma brucei aurora B kinase 0.0083 0.0455 0.1667
Brugia malayi Protein kinase domain containing protein 0.0049 0.0084 0.0084
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0066 0.0273 0.0547
Echinococcus multilocularis PAK box P21 Rho binding 0.0058 0.0176 0.0353
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0077 0.0387 0.2945
Brugia malayi casein kinase I 0.0102 0.0672 0.0672
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0151 0.1209 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0094 0.0585 0.2209
Loa Loa (eye worm) hypothetical protein 0.0121 0.0882 0.0882
Onchocerca volvulus 0.0077 0.0387 0.1069
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0455 0.0949
Schistosoma mansoni hypothetical protein 0.0062 0.0224 0.0466
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0362 0.0755
Entamoeba histolytica p21-activated kinase 0.0084 0.0465 0.1707
Entamoeba histolytica protein kinase, putative 0.0077 0.0386 0.1402
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0418 0.1526
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0362 0.1308
Entamoeba histolytica casein kinase, putative 0.0094 0.0577 0.2138
Entamoeba histolytica protein kinase, putative 0.0079 0.0419 0.1528
Loa Loa (eye worm) thyroid receptor interactor 0.0091 0.0549 0.0549
Schistosoma mansoni rap gtpase-activating protein 0.0113 0.079 0.1648
Echinococcus granulosus cyclin dependent kinase 0.0113 0.0786 0.1575
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0048 0.0068 0.0068
Loa Loa (eye worm) TK protein kinase 0.0085 0.0486 0.0486
Echinococcus multilocularis serine:threonine protein kinase 0.0108 0.0734 0.147
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0222 0.2002 0.4011
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0066 0.0273 0.2103
Toxoplasma gondii CMGC kinase, CK2 family 0.0094 0.0577 0.2177
Entamoeba histolytica protein kinase, putative 0.0062 0.0222 0.0768
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0077 0.0393 0.1455
Echinococcus multilocularis nervana 2 0.0125 0.0924 0.1851
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0074 0.0354 0.0354
Brugia malayi Protein kinase domain containing protein 0.0148 0.1179 0.1179
Entamoeba histolytica protein kinase, putative 0.0116 0.0824 0.3096
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0455 0.1667
Entamoeba histolytica protein kinase, putative 0.0085 0.0486 0.1787
Loa Loa (eye worm) hypothetical protein 0.0175 0.1476 0.1476
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0206 0.0206
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0319 0.1143
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0079 0.0419 0.084
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0113 0.079 0.6221
Echinococcus multilocularis rho associated protein kinase 0.0321 0.3096 0.6204
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.006 0.0204 0.1521
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.1293 0.2696
Brugia malayi SRC-1 0.0127 0.0947 0.0947
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0258 0.2396 0.4801
Schistosoma mansoni apoptosis regulator bax 0.0258 0.2396 0.4996
Echinococcus granulosus growth factor receptor bound protein 2 0.0044 0.0022 0.0045
Brugia malayi Protein kinase domain containing protein 0.0116 0.0824 0.0824
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0123 0.0896 0.7084
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0079 0.0419 0.084
Leishmania major protein kinase A catalytic subunit isoform 2 0.0066 0.0273 0.2055
Loa Loa (eye worm) hypothetical protein 0.006 0.0204 0.0204
Schistosoma mansoni vam6/vps39 related 0.0113 0.079 0.1648
Echinococcus multilocularis casein kinase ii subunit alpha 0.0094 0.0577 0.1156
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0083 0.0455 0.3636
Onchocerca volvulus 0.0083 0.0453 0.126
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0123 0.0896 0.1796
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0349 0.3403 0.6819
Trypanosoma brucei SNF1-related protein kinases, putative 0.006 0.0204 0.0697
Plasmodium falciparum calcium-dependent protein kinase 4 0.0094 0.0585 0.4733
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0115 0.0813 0.6501
Brugia malayi Stress-activated protein kinase jnk-1 0.026 0.2414 0.2414
Loa Loa (eye worm) hypothetical protein 0.0049 0.008 0.008
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0116 0.0824 0.65
Trichomonas vaginalis AGC family protein kinase 0.0083 0.0455 0.1667
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0077 0.0393 0.3045
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0094 0.0585 0.0585
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0074 0.0363 0.286
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0387 0.0807
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0058 0.0177 0.0368
Echinococcus multilocularis casein kinase I alpha 0.0102 0.0672 0.1348
Onchocerca volvulus 0.0117 0.0836 0.2367
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0049 0.0084 0.0168
Echinococcus granulosus serine:threonine kinase SAD 1 0.006 0.0204 0.0409
Brugia malayi Protein kinase domain containing protein 0.0195 0.1703 0.1703
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0078 0.0404 0.1469
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0362 0.1308
Loa Loa (eye worm) hypothetical protein 0.0087 0.05 0.05
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0052 0.0115 0.0231
Echinococcus multilocularis neuroglian 0.0063 0.0234 0.0469
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0083 0.0455 0.0912
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0363 0.3562 0.3562
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0078 0.0404 0.3084
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0084 0.0084
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0431 0.4313 0.8644
Entamoeba histolytica cell division protein kinase 2, putative 0.0113 0.0786 0.2948
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0206 0.0206
Toxoplasma gondii casein kinase I 0.0102 0.0672 0.2554
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0461 0.169
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0078 0.0404 0.1469
Echinococcus granulosus Immunoglobulin 0.0049 0.008 0.0161
Brugia malayi serine/threonine protein kinase 6 0.0083 0.0455 0.0455
Trichomonas vaginalis CK1 family protein kinase 0.0102 0.0672 0.2508
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0123 0.0896 0.0896
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.1724 0.3596
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0113 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.014 0.1093 0.1093
Entamoeba histolytica protein kinase, putative 0.0083 0.0455 0.1667
Loa Loa (eye worm) hypothetical protein 0.0054 0.0133 0.0133
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0252 0.2331 0.2331
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Brugia malayi protein unc-22 0.0056 0.0154 0.0154
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0094 0.0585 0.4733
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.1943 0.4053
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0074 0.0362 0.2786
Entamoeba histolytica protein kinase domain containing protein 0.0123 0.0896 0.3375
Schistosoma mansoni protein kinase 0.0079 0.0419 0.0874
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0079 0.0419 0.084
Echinococcus multilocularis Immunoglobulin 0.0049 0.008 0.0161
Echinococcus granulosus raf serine:threonine protein kinase 0.0061 0.0213 0.0426
Loa Loa (eye worm) hypothetical protein 0.0466 0.4704 0.4704
Echinococcus multilocularis serine:threonine protein kinase 3 0.0252 0.2331 0.4671
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0362 0.1308
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0233 0.2121 0.425
Echinococcus granulosus rho-associated protein kinase 1 0.0321 0.3096 0.6204
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0461 0.0961
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0492 0.499 1
Trypanosoma brucei protein kinase, putative 0.0077 0.0393 0.1429
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0139 0.1077 0.2159
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0108 0.0734 0.0734
Echinococcus granulosus dual specificity 0.0079 0.0418 0.0839
Echinococcus granulosus casein kinase I alpha 0.0102 0.0672 0.1348
Echinococcus granulosus mitogen activated protein kinase 3 0.0077 0.0393 0.0788
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0386 0.0806
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0058 0.0177 0.0354
Brugia malayi Serine/threonine-protein kinase SULU 0.0217 0.1943 0.1943
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0066 0.0273 0.2103
Brugia malayi C1-like domain containing protein 0.0143 0.1122 0.1122
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.0115 0.0742
Echinococcus multilocularis tyrosine protein kinase Blk 0.0108 0.074 0.1483
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0094 0.0585 0.4733
Trichomonas vaginalis STE family protein kinase 0.0079 0.0419 0.1528
Schistosoma mansoni tyrosine kinase 0.0051 0.0106 0.0221
Entamoeba histolytica PH domain containing protein kinase, putative 0.0155 0.1256 0.4764
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.006 0.0204 0.1486
Echinococcus multilocularis serine:threonine protein kinase N2 0.0148 0.1179 0.2363
Loa Loa (eye worm) protein kinase domain-containing protein 0.0208 0.1843 0.1843
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0154 0.0154
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0066 0.0273 0.0547
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0075 0.0368 0.0738
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0672 0.1402
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0049 0.0084 0.0168
Trypanosoma cruzi p21-activated kinase 3, putative 0.0048 0.0068 0.0357
Onchocerca volvulus 0.0044 0.0032 0.0043
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0066 0.0273 0.0982
Plasmodium falciparum casein kinase 2, alpha subunit 0.0094 0.0577 0.4664
Echinococcus multilocularis rac serine:threonine kinase 0.0155 0.1256 0.2516
Brugia malayi serine/threonine-protein kinase plk-2 0.0074 0.0362 0.0362
Trichomonas vaginalis AGC family protein kinase 0.013 0.098 0.3698
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0102 0.0672 0.0672
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0066 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0108 0.0734 0.0734
Leishmania major protein kinase, putative 0.0083 0.0455 0.3552
Trichomonas vaginalis AGC family protein kinase 0.0148 0.1179 0.4468
Loa Loa (eye worm) AGC/PKN protein kinase 0.0279 0.263 0.263
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0078 0.0404 0.3084
Schistosoma mansoni tyrosine kinase 0.0068 0.029 0.0605
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0084 0.0084
Onchocerca volvulus 0.0113 0.079 0.2234
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0447 0.449 0.8998
Onchocerca volvulus 0.0083 0.0461 0.1283
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0113 0.0786 0.6281
Entamoeba histolytica protein kinase domain containing protein 0.0083 0.0455 0.1667
Echinococcus granulosus tyrosine kinase 0.0049 0.0084 0.0168
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.0115 0.0742
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0362 0.1308
Schistosoma mansoni vesicular amine transporter 0.0049 0.008 0.0167
Schistosoma mansoni serine/threonine protein kinase 0.0475 0.4795 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0256 0.0256
Giardia lamblia Kinase, CMGC CLK 0.0148 0.1176 0.9718
Entamoeba histolytica protein kinase, putative 0.0148 0.1179 0.4468
Echinococcus multilocularis calcium activated potassium channel 0.0088 0.0509 0.1021
Brugia malayi STE20-like kinase MST 0.0252 0.2331 0.2331
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0151 0.0302
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0108 0.074 0.1483
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.006 0.0204 0.0204
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0217 0.1943 0.3895
Schistosoma mansoni ste20-related kinase 0.02 0.1752 0.3654
Onchocerca volvulus 0.0065 0.0256 0.0691
Leishmania major casein kinase II, putative 0.0094 0.0577 0.4556
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0148 0.1179 0.2363
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0222 0.2002 0.4011
Loa Loa (eye worm) hypothetical protein 0.0065 0.0256 0.0256
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0066 0.0273 0.0547
Echinococcus multilocularis Glutaredoxin protein 5 0.0125 0.0924 0.1851
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0079 0.0419 0.084
Onchocerca volvulus 0.0123 0.0896 0.2541
Echinococcus granulosus Vam6:Vps39 protein 0.0113 0.079 0.1583
Echinococcus granulosus defective proboscis extension response 0.0049 0.008 0.0161
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0116 0.0824 0.6597
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0148 0.1176 0.1176
Echinococcus multilocularis c Jun NH2 terminal kinase 0.026 0.2414 0.4838
Brugia malayi hypothetical protein 0.0113 0.079 0.079
Loa Loa (eye worm) hypothetical protein 0.006 0.02 0.02
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0113 0.079 0.1648
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0148 0.1176 0.4456
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0368 0.1332
Echinococcus multilocularis tyrosine protein kinase 0.0269 0.2513 0.5037
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0113 0.0786 0.1575
Echinococcus granulosus casein kinase I alpha 0.0102 0.0672 0.1348
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0123 0.0896 0.1869
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0362 0.1308
Onchocerca volvulus 0.0049 0.0084 0.0194
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.013 0.098 0.3765
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0234 0.2135 0.4279
Brugia malayi serine/threonine-protein kinase PAK 7 0.0227 0.2054 0.2054
Schistosoma mansoni tyrosine kinase 0.0126 0.0939 0.1958
Giardia lamblia Kinase, CDC7 0.0083 0.0461 0.3687
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0108 0.0739 0.0739
Schistosoma mansoni tyrosine kinase 0.0236 0.2157 0.4499
Brugia malayi probable protein kinase 0.026 0.2421 0.2421
Echinococcus granulosus protein kinase 0.0147 0.117 0.2345
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0446 0.4477 0.4477
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0577 0.2138
Echinococcus granulosus calcium activated potassium channel 0.0088 0.0509 0.1021
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0273 0.2563 0.2563
Echinococcus granulosus nervana 2 0.0125 0.0924 0.1851
Echinococcus granulosus twitchin 0.0089 0.052 0.1042
Schistosoma mansoni serine/threonine protein kinase 0.017 0.1418 0.2957
Echinococcus multilocularis serine:threonine protein kinase 0.0108 0.0734 0.147
Entamoeba histolytica protein kinase , putative 0.0083 0.0455 0.1667
Schistosoma mansoni hypothetical protein 0.0113 0.079 0.1648
Entamoeba histolytica protein kinase, putative 0.0116 0.0824 0.3096
Loa Loa (eye worm) hypothetical protein 0.0065 0.0256 0.0256
Schistosoma mansoni tyrosine kinase 0.0068 0.029 0.0605
Schistosoma mansoni tyrosine kinase 0.0058 0.0181 0.0377
Echinococcus granulosus tyrosine protein kinase Srms 0.0461 0.4647 0.9313
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0155 0.1256 1
Onchocerca volvulus 0.0102 0.0672 0.1894
Brugia malayi protein kinase C II. 0.0184 0.1576 0.1576
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0079 0.0418 0.3203
Trichomonas vaginalis CAMK family protein kinase 0.0074 0.0362 0.1308
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0393 0.1429
Schistosoma mansoni serine/threonine-protein kinase 0.0155 0.1256 0.2618
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0824 0.1719
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0258 0.2396 0.4996
Loa Loa (eye worm) TK/EGFR protein kinase 0.0236 0.2157 0.2157
Onchocerca volvulus 0.0049 0.0084 0.0194
Onchocerca volvulus 0.0295 0.281 0.8068
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0079 0.0418 0.1554
Schistosoma mansoni protein kinase 0.0052 0.0115 0.024
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0418 0.1526
Echinococcus granulosus mitogen activated protein kinase 14 0.0153 0.1237 0.248
Echinococcus granulosus hypothetical protein 0.0122 0.089 0.1784
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0327 0.3166 0.3166
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0148 0.1176 0.9354
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0077 0.0393 0.3
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0123 0.0896 0.1796
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.0115 0.0354
Entamoeba histolytica protein kinase, putative 0.0273 0.2563 0.9821
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0127 0.0947 0.1897
Echinococcus granulosus serine:threonine protein kinase MARK2 0.017 0.1418 0.2841
Brugia malayi Protein kinase domain containing protein 0.0088 0.0509 0.0509
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0195 0.1703 0.3413
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0077 0.0386 0.1402
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.0896 0.3375
Schistosoma mansoni protein kinase 0.0079 0.0419 0.0874
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.0786 0.2948
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0127 0.0947 0.1897
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.2121 0.4422
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0094 0.0585 0.1172
Entamoeba histolytica protein kinase, putative 0.0094 0.0585 0.217
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0151 0.0302
Echinococcus granulosus calcium dependent protein kinase 0.0069 0.0299 0.0599
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0151 0.1209 0.9625
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.006 0.0204 0.1464
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Echinococcus multilocularis 0.0064 0.0251 0.0504
Loa Loa (eye worm) hypothetical protein 0.0083 0.0453 0.0453
Echinococcus granulosus aurora kinase A 0.0083 0.0455 0.0912
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0066 0.0273 0.2024
Loa Loa (eye worm) casein kinase 0.0182 0.1557 0.1557
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0391 0.3869 0.3869
Brugia malayi Protein kinase domain containing protein 0.0077 0.0386 0.0386
Entamoeba histolytica casein kinase, putative 0.0102 0.0672 0.2508
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0127 0.0947 0.1897
Schistosoma mansoni kinase 0.0187 0.1614 0.3366
Echinococcus granulosus Glutaredoxin protein 5 0.0125 0.0924 0.1851
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0079 0.0418 0.0418
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0077 0.0393 0.3
Leishmania major protein kinase, putative 0.0148 0.1176 0.9494
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0083 0.0455 0.1667
Echinococcus granulosus c src tyrosine kinase 0.0068 0.029 0.0582
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0197 0.1724 0.1724
Trichomonas vaginalis AGC family protein kinase 0.0277 0.261 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0206 0.0206
Echinococcus granulosus casein kinase ii subunit alpha 0.0094 0.0577 0.1156
Toxoplasma gondii aurora kinase 0.0083 0.0455 0.1697
Echinococcus multilocularis roundabout 2 0.0089 0.0529 0.106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0151 0.0315
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.202 0.4213
Giardia lamblia Kinase, NEK 0.013 0.098 0.8066
Brugia malayi Tyrosine-protein kinase abl-1 0.0068 0.029 0.029
Schistosoma mansoni vav2 0.0062 0.0223 0.0464
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0084 0.0472 0.0946
Echinococcus multilocularis cyclin dependent kinase 0.0113 0.0786 0.1575
Loa Loa (eye worm) hypothetical protein 0.0065 0.0256 0.0256
Leishmania major protein kinase A catalytic subunit 0.0066 0.0273 0.2055
Echinococcus granulosus tyrosine protein kinase shark 0.0049 0.0084 0.0168
Entamoeba histolytica protein kinase domain containing protein 0.0094 0.0577 0.2138
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0074 0.0362 0.0725
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0148 0.1179 0.2363
Echinococcus multilocularis cyclin dependent kinase 5 0.0113 0.0786 0.1575
Brugia malayi Casein kinase II, alpha chain 0.0094 0.0577 0.0577
Giardia lamblia Kinase, STE STE20 0.0078 0.0404 0.3204
Trypanosoma brucei cdc2-related kinase 3 0.0113 0.0786 0.2948
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0577 0.2138
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0113 0.079 0.6221
Trypanosoma brucei polo-like protein kinase 0.0074 0.0362 0.1308
Giardia lamblia Kinase, CMGC DYRK 0.0079 0.0418 0.3328
Brugia malayi phosphoinositide-dependent protein kinase I 0.0075 0.0368 0.0368
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0084 0.0084
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0049 0.0084 0.0168
Onchocerca volvulus 0.014 0.1093 0.3108
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0139 0.1076 0.2156
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0127 0.0947 0.1897
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0204 0.0426
Entamoeba histolytica protein kinase, putative 0.0062 0.0222 0.0768
Echinococcus multilocularis mitogen activated protein kinase 14 0.0153 0.1237 0.248
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.006 0.0204 0.0697
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0077 0.0393 0.0393
Schistosoma mansoni tyrosine kinase 0.0049 0.0084 0.0174
Loa Loa (eye worm) hypothetical protein 0.0073 0.0343 0.0343
Trichomonas vaginalis AGC family protein kinase 0.0152 0.1225 0.4646
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0123 0.0896 0.7191
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0151 0.1209 0.2424
Brugia malayi Hr1 repeat family protein 0.0279 0.263 0.263
Brugia malayi hypothetical protein 0.0049 0.0084 0.0084
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0123 0.0896 0.0896
Loa Loa (eye worm) hypothetical protein 0.0062 0.0224 0.0224
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0577 0.2138
Trypanosoma cruzi cdc2-related kinase 1 0.0113 0.0786 0.6188
Brugia malayi Protein kinase domain containing protein 0.0099 0.0633 0.0633
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0139 0.1077 0.2159
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0148 0.1179 0.2363
Brugia malayi Fes/CIP4 homology domain containing protein 0.0091 0.0549 0.0549
Echinococcus multilocularis nervana 2 0.0125 0.0924 0.1851
Echinococcus granulosus serine:threonine protein kinase 0.0108 0.0734 0.147
Echinococcus granulosus dual specificity 0.0079 0.0418 0.0839
Brugia malayi ephrin receptor 1 precursor 0.0057 0.0167 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0133 0.0422
Schistosoma mansoni tyrosine kinase 0.014 0.109 0.2274
Loa Loa (eye worm) AUR protein kinase 0.0083 0.0455 0.0455
Entamoeba histolytica protein kinase domain containing protein 0.0079 0.0418 0.1526
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0151 0.0302
Plasmodium falciparum glycogen synthase kinase 3 0.0123 0.0896 0.736
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0158 0.1293 0.1293
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0143 0.1122 0.1122
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.0115 0.0354
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0431 0.4313 0.8644
Echinococcus multilocularis 0.0122 0.089 0.1784
Echinococcus granulosus epidermal growth factor receptor 0.0166 0.1381 0.2767
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0126 0.0939 0.1882
Echinococcus granulosus serine threonine protein kinase nrc 0.0151 0.1209 0.2424
Echinococcus multilocularis casein kinase I gamma 0.0208 0.1843 0.3693
Loa Loa (eye worm) hypothetical protein 0.009 0.0539 0.0539
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0058 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0075 0.0366 0.0366
Loa Loa (eye worm) TK protein kinase 0.0269 0.2513 0.2513
Brugia malayi Protein kinase domain containing protein 0.0055 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0258 0.2396 0.4996
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0078 0.0404 0.1469
Brugia malayi Temporarily assigned gene name protein 59 0.0113 0.079 0.079
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0258 0.2396 0.2396
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0052 0.0115 0.0231
Echinococcus granulosus casein kinase I delta 0.0102 0.0672 0.1348
Giardia lamblia Kinase, PLK 0.0074 0.0362 0.2852
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0368 0.1332
Loa Loa (eye worm) TK/ABL protein kinase 0.0049 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0242 0.2223 0.2223
Brugia malayi Variant SH3 domain containing protein 0.0058 0.0177 0.0177
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0217 0.1943 0.3895
Trichomonas vaginalis CK1 family protein kinase 0.0102 0.0672 0.2508
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0337 0.3268 0.3268
Brugia malayi Protein kinase domain containing protein 0.0181 0.154 0.154
Schistosoma mansoni protein kinase 0.0102 0.0672 0.1402
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0077 0.0393 0.3
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0217 0.1943 0.1943
Brugia malayi serine/threonine kinase 12 0.0083 0.0455 0.0455
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0734 0.2745
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0197 0.1724 0.1724
Giardia lamblia Kinase, STE STE20 0.0079 0.0419 0.3333
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0083 0.0455 0.1667
Echinococcus multilocularis serine:threonine protein kinase N2 0.0131 0.0991 0.1985
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.006 0.0204 0.0409
Schistosoma mansoni protein kinase 0.0052 0.0115 0.024
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0094 0.0585 0.4733
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0077 0.0393 0.1429
Plasmodium vivax serine/threonine protein kinase, putative 0.0077 0.0386 0.3058
Echinococcus multilocularis mitogen activated protein kinase 0.0077 0.0393 0.0788
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0094 0.0585 0.1172
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0079 0.0418 0.0418
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0083 0.0455 0.0912
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0066 0.0273 0.0964
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0056 0.0154 0.0154
Echinococcus granulosus mitogen activated protein kinase 0.0077 0.0393 0.0788
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0084 0.0084
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0077 0.0393 0.3045
Trichomonas vaginalis STE family protein kinase 0.0079 0.0419 0.1528
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0204 0.0426
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0577 0.2138
Loa Loa (eye worm) AGC/AKT protein kinase 0.0277 0.261 0.261
Echinococcus granulosus ephrin type A receptor 4 A 0.0091 0.0546 0.1094
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0184 0.1576 0.1576
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.1843 0.3843
Schistosoma mansoni tyrosine kinase 0.0206 0.1819 0.3792
Echinococcus multilocularis aurora kinase A 0.0083 0.0455 0.0912
Trypanosoma cruzi casein kinase, putative 0.0102 0.0672 0.5266
Echinococcus multilocularis NCK adaptor protein 0.0044 0.0022 0.0045
Echinococcus multilocularis protein kinase c epsilon type 0.0184 0.1576 0.3159
Loa Loa (eye worm) TK protein kinase 0.014 0.1093 0.1093
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0204 0.0426
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0048 0.0068 0.0068
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0075 0.0368 0.0368
Schistosoma mansoni serine/threonine protein kinase 0.017 0.1418 0.2957
Brugia malayi Protein kinase domain containing protein 0.0349 0.3403 0.3403
Schistosoma mansoni protein kinase 0.0431 0.4313 0.8995
Onchocerca volvulus Serine\/threonine kinase homolog 0.0158 0.1293 0.3686
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0461 0.169
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0058 0.0177 0.0354
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0084 0.0084
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0222 0.1994 0.3996
Brugia malayi hypothetical protein 0.0065 0.0256 0.0256
Schistosoma mansoni tyrosine kinase 0.0127 0.0947 0.1974
Schistosoma mansoni titin 0.0056 0.0154 0.0321
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0273 0.057
Echinococcus granulosus neuroglian 0.0063 0.0234 0.0469
Giardia lamblia Kinase, CMGC CK2 0.0094 0.0577 0.4664
Onchocerca volvulus 0.0316 0.3035 0.8717
Schistosoma mansoni protein kinase 0.0058 0.0176 0.0367
Entamoeba histolytica protein kinase, putative 0.0049 0.0079 0.0214
Trypanosoma cruzi SNF1-related protein kinases, putative 0.006 0.0204 0.1464
Loa Loa (eye worm) hypothetical protein 0.0122 0.089 0.089
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0127 0.0947 0.1897
Giardia lamblia Kinase, CMGC CDK 0.0113 0.0786 0.6429
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0077 0.0386 0.0386
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0153 0.1237 0.4693
Loa Loa (eye worm) AUR protein kinase 0.0083 0.0455 0.0455
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0094 0.0585 0.217
Loa Loa (eye worm) hypothetical protein 0.0113 0.079 0.079
Echinococcus multilocularis c src tyrosine kinase 0.0068 0.029 0.0582
Brugia malayi serine/threonine-protein kinase 6 0.0083 0.0455 0.0455
Brugia malayi Protein kinase domain containing protein 0.0075 0.0368 0.0368
Trichomonas vaginalis AGC family protein kinase 0.0277 0.261 1
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0509 0.1062
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0052 0.0115 0.036
Brugia malayi Protein kinase domain containing protein 0.0206 0.1819 0.1819
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0024 0.005
Brugia malayi Protein kinase c protein 2 0.0102 0.0666 0.0666
Echinococcus granulosus casein kinase i 0.0102 0.0672 0.1348
Echinococcus multilocularis cyclin dependent kinase 1 0.0113 0.0786 0.1575
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.1703 0.3552
Onchocerca volvulus 0.0049 0.0084 0.0194
Leishmania major protein kinase, putative 0.0078 0.0404 0.3131
Giardia lamblia Kinase, AGC PKA 0.0066 0.0273 0.2103
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.1176 0.2452
Trichomonas vaginalis AGC family protein kinase 0.0277 0.261 1
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0786 0.1639
Entamoeba histolytica protein kinase domain containing protein 0.0197 0.1724 0.6576
Brugia malayi Protein kinase domain containing protein 0.0277 0.261 0.261
Echinococcus multilocularis protein kinase shaggy 0.0123 0.0896 0.1796
Echinococcus granulosus titin 0.0056 0.0154 0.0309
Echinococcus multilocularis tyrosine protein kinase Abl 0.0068 0.029 0.0582
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0273 0.057
Loa Loa (eye worm) TK/INSR protein kinase 0.0206 0.1819 0.1819
Giardia lamblia Kinase, CMGC MAPK 0.0077 0.0393 0.3117
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.006 0.02 0.04
Schistosoma mansoni nephrin 0.0079 0.0409 0.0854
Echinococcus multilocularis casein kinase I delta 0.0102 0.0672 0.1348
Loa Loa (eye worm) hypothetical protein 0.014 0.1093 0.1093
Echinococcus multilocularis mitogen activated protein kinase 11 0.0153 0.1237 0.248
Brugia malayi Protein kinase domain containing protein 0.0049 0.0084 0.0084
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0577 0.2138
Echinococcus multilocularis calcium dependent protein kinase 0.0069 0.0299 0.0599
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.006 0.0204 0.0409
Plasmodium falciparum serine/threonine protein kinase 0.0077 0.0386 0.3058
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0094 0.0585 0.2209
Entamoeba histolytica protein kinase domain containing protein 0.0116 0.0824 0.3096
Echinococcus granulosus activin receptor type 0.0052 0.0115 0.0231
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0153 0.1237 1
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0153 0.1237 0.9852
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.017 0.1418 0.2841
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0084 0.0084
Plasmodium falciparum casein kinase 1 0.0102 0.0672 0.5471
Echinococcus granulosus serine/threonine protein kinase 0.0155 0.1256 0.2516
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0102 0.0672 0.0672
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0077 0.0386 0.1427
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0066 0.0273 0.2024
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0418 0.1526
Brugia malayi Cam kinase protein 1 0.0094 0.0585 0.0585
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0074 0.0362 0.0725
Brugia malayi Kinase associated domain 1 family protein 0.0062 0.0224 0.0224
Echinococcus granulosus roundabout 2 0.0089 0.0529 0.106
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0113 0.079 0.1583
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0066 0.0273 0.0547
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0577 0.2138
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0066 0.0273 0.2024
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0079 0.0419 0.084
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0127 0.0947 0.1897
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0125 0.0924 0.1851
Brugia malayi Protein kinase domain containing protein 0.0363 0.3562 0.3562
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0068 0.029 0.0582
Loa Loa (eye worm) AGC/NDR protein kinase 0.0148 0.1179 0.1179
Echinococcus granulosus casein kinase I gamma 0.0208 0.1843 0.3693
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0111 0.0767 0.0767
Plasmodium falciparum serine/threonine protein kinase, putative 0.0083 0.0455 0.3636
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Trichomonas vaginalis CK1 family protein kinase 0.0102 0.0672 0.2508
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0127 0.0947 0.1897
Echinococcus granulosus protein kinase shaggy 0.0123 0.0896 0.1796
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0148 0.1179 0.1179
Echinococcus granulosus tyrosine protein kinase Src64B 0.0127 0.0947 0.1897
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0049 0.008 0.0161
Schistosoma mansoni tyrosine kinase 0.0166 0.1381 0.2879
Entamoeba histolytica protein kinase domain containing protein 0.0123 0.0896 0.3375
Entamoeba histolytica protein kinase, putative 0.0079 0.0418 0.1526
Loa Loa (eye worm) TK protein kinase 0.0108 0.074 0.074
Echinococcus granulosus Protein kinase C brain isozyme 0.0224 0.202 0.4048
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0094 0.0577 0.0577
Onchocerca volvulus 0.0083 0.0461 0.1283
Loa Loa (eye worm) hypothetical protein 0.0288 0.2733 0.2733
Trichomonas vaginalis STE family protein kinase 0.0078 0.0404 0.1469
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.2002 0.4174
Plasmodium falciparum protein kinase 5 0.0113 0.0786 0.6429
Schistosoma mansoni protein kinase C mu 0.0143 0.1122 0.2339
Echinococcus granulosus dual specificity 0.0116 0.0824 0.1652
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.2002 0.4174
Schistosoma mansoni protein kinase 0.0187 0.1614 0.3367
Echinococcus granulosus dual specificity 0.0079 0.0418 0.0839
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0102 0.0672 0.5266
Giardia lamblia Kinase, CAMK CAMKL 0.006 0.0204 0.1521
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0391 0.3869 0.7753
Echinococcus granulosus epidermal growth factor receptor 0.0236 0.2157 0.4323
Entamoeba histolytica protein kinase 2, putative 0.0151 0.1209 0.4585
Echinococcus multilocularis expressed protein 0.0077 0.0386 0.0774
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0126 0.0939 0.1882
Plasmodium falciparum protein kinase, putative 0.0052 0.0115 0.0771
Brugia malayi intracellular kinase 0.0123 0.0896 0.0896
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0077 0.0386 0.2987
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0151 0.1209 0.2424
Brugia malayi Protein kinase domain containing protein 0.0269 0.2513 0.2513
Leishmania major protein kinase A catalytic subunit isoform 1 0.0066 0.0273 0.2055
Brugia malayi Immunoglobulin I-set domain containing protein 0.0065 0.0256 0.0256
Echinococcus granulosus cyclin dependent kinase 1 0.0113 0.0786 0.1575
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0349 0.3403 0.3403
Schistosoma mansoni protein kinase 0.0431 0.4313 0.8995
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0363 0.3562 0.7137
Echinococcus multilocularis insulin receptor 0.0206 0.1819 0.3644
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0066 0.0274 0.0274
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0227 0.2054 0.2054
Entamoeba histolytica PH domain containing protein kinase, putative 0.0155 0.1256 0.4764
Leishmania major protein kinase, putative 0.0052 0.0115 0.0754
Loa Loa (eye worm) AUR protein kinase 0.0083 0.0455 0.0455
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0509 0.1878
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0116 0.0824 0.3096
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0094 0.0585 0.0585
Loa Loa (eye worm) hypothetical protein 0.0113 0.079 0.079
Trichomonas vaginalis CMGC family protein kinase 0.0083 0.0461 0.169
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0148 0.1176 0.4537
Echinococcus granulosus tyrosine protein kinase Src42A 0.0127 0.0947 0.1897
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0147 0.117 0.117
Schistosoma mansoni hypothetical protein 0.0062 0.0224 0.0466
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0116 0.0824 0.65
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0048 0.0068 0.0068
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0049 0.008 0.0167
Echinococcus multilocularis epidermal growth factor receptor 0.0236 0.2157 0.4323
Echinococcus granulosus tyrosine protein kinase Fyn 0.0127 0.0947 0.1897
Schistosoma mansoni protein kinase 0.026 0.2421 0.5049
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0148 0.1179 0.2363
Loa Loa (eye worm) hypothetical protein 0.0049 0.0083 0.0083
Entamoeba histolytica protein kinase, putative 0.0277 0.261 1
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0418 0.1526
Trypanosoma brucei Casein kinase II 0.0094 0.0577 0.2138
Schistosoma mansoni ephrin receptor 0.0091 0.0546 0.1139
Loa Loa (eye worm) hypothetical protein 0.009 0.0539 0.0539
Brugia malayi Furin-like cysteine rich region family protein 0.0236 0.2157 0.2157
Loa Loa (eye worm) hypothetical protein 0.0234 0.2135 0.2135
Loa Loa (eye worm) apoptosis regulator protein 0.0258 0.2396 0.2396
Toxoplasma gondii AGC kinase 0.0273 0.2563 1
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.0786 0.2948
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0206 0.0206
Entamoeba histolytica protein kinase, putative 0.0123 0.0896 0.3375
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0153 0.1237 0.9852
Brugia malayi cell division control protein 2 homolog 0.0113 0.0786 0.0786
Schistosoma mansoni serine/threonine kinase 0.0148 0.1179 0.2459
Schistosoma mansoni serine/threonine protein kinase 0.026 0.2414 0.5035
Echinococcus multilocularis raf serine:threonine protein kinase 0.0061 0.0213 0.0426
Schistosoma mansoni serine/threonine protein kinase 0.0279 0.263 0.5485
Echinococcus multilocularis 0.0147 0.117 0.2345
Giardia lamblia Kinase, CMGC SRPK 0.0077 0.0386 0.3058
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0151 0.0151
Toxoplasma gondii AGC kinase 0.0066 0.0273 0.0982
Schistosoma mansoni tyrosine kinase 0.0206 0.1819 0.3792
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0079 0.0418 0.1526
Giardia lamblia Aurora kinase 0.0083 0.0455 0.3636
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0213 0.0443
Echinococcus multilocularis myosin iiia 0.0078 0.0404 0.0809
Onchocerca volvulus 0.0049 0.0084 0.0194
Trichomonas vaginalis AGC family protein kinase 0.0075 0.0368 0.1332
Trichomonas vaginalis STE family protein kinase 0.0079 0.0419 0.1528
Plasmodium vivax tyrosine kinase-like protein, putative 0.0074 0.0363 0.286
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0195 0.1703 0.3413
Brugia malayi putative serine/threonine kinase SADA gamma 0.006 0.0204 0.0204
Echinococcus multilocularis tyrosine protein kinase Srms 0.0108 0.074 0.1483
Trichomonas vaginalis AGC family protein kinase 0.0277 0.261 1
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0204 0.0697
Echinococcus multilocularis serine threonine protein kinase 0.0189 0.1637 0.3281
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0349 0.3403 0.6819
Entamoeba histolytica serine/threonine protein kinase, putative 0.0074 0.0362 0.1308
Schistosoma mansoni serine/threonine kinase 0.0088 0.0509 0.1062
Giardia lamblia Kinase, CMGC GSK 0.0123 0.0896 0.736
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0094 0.0585 0.0585
Entamoeba histolytica protein kinase, putative 0.0096 0.0599 0.2225
Echinococcus multilocularis titin 0.0056 0.0154 0.0309
Plasmodium falciparum calcium-dependent protein kinase 5 0.0094 0.0585 0.4733
Loa Loa (eye worm) hypothetical protein 0.012 0.0871 0.0871
Echinococcus multilocularis tyrosine protein kinase shark 0.0049 0.0084 0.0168
Loa Loa (eye worm) CAMK protein kinase 0.0056 0.0154 0.0154
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0233 0.2121 0.425

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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