Detailed information for compound 160139

Basic information

Technical information
  • TDR Targets ID: 160139
  • Name: tert-butyl N-[(2S,3S,5R)-6-[[(2S)-1-amino-3-m ethyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydr oxy-6-oxo-1-phenylhexan-2-yl]carbamate
  • MW: 525.68 | Formula: C30H43N3O5
  • H donors: 4 H acceptors: 4 LogP: 4.6 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCC([C@@H](C(=O)N)NC(=O)[C@H](Cc1ccccc1)C[C@@H]([C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)O)C
  • InChi: 1S/C30H43N3O5/c1-6-20(2)26(27(31)35)33-28(36)23(17-21-13-9-7-10-14-21)19-25(34)24(18-22-15-11-8-12-16-22)32-29(37)38-30(3,4)5/h7-16,20,23-26,34H,6,17-19H2,1-5H3,(H2,31,35)(H,32,37)(H,33,36)/t20?,23-,24+,25+,26+/m1/s1
  • InChiKey: LJBDZBPRKRUUJF-DGEOFYIOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • tert-butyl N-[(1S,2S,4R)-1,4-dibenzyl-5-[[(1S)-1-carbamoyl-2-methyl-butyl]amino]-2-hydroxy-5-oxo-pentyl]carbamate
  • N-[(1S,2S,4R)-1,4-dibenzyl-5-[[(1S)-1-carbamoyl-2-methylbutyl]amino]-2-hydroxy-5-oxopentyl]carbamic acid tert-butyl ester
  • tert-butyl N-[(2S,3S,5R)-6-[[(2S)-1-azanyl-3-methyl-1-oxo-pentan-2-yl]amino]-3-hydroxy-6-oxo-1-phenyl-5-(phenylmethyl)hexan-2-yl]carbamate
  • N-[(1S,2S,4R)-1,4-dibenzyl-5-[[(1S)-1-carbamoyl-2-methyl-butyl]amino]-2-hydroxy-5-keto-pentyl]carbamic acid tert-butyl ester
  • tert-butyl N-[(2S,3S,5R)-6-[[(2S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-6-oxo-1-phenyl-5-(phenylmethyl)hexan-2-yl]carbamate
  • tert-butyl N-[(1S,2S,4R)-5-[[(1S)-1-carbamoyl-2-methyl-butyl]amino]-2-hydroxy-5-oxo-1,4-bis(phenylmethyl)pentyl]carbamate
  • N-[(1S,2S,4R)-5-[[(1S)-1-carbamoyl-2-methylbutyl]amino]-2-hydroxy-5-oxo-1,4-bis(phenylmethyl)pentyl]carbamic acid tert-butyl ester
  • N-[(1S,2S,4R)-1,4-bis(benzyl)-5-[[(1S)-1-carbamoyl-2-methyl-butyl]amino]-2-hydroxy-5-keto-pentyl]carbamic acid tert-butyl ester
  • tert-butyl N-[(2S,3S,5R)-6-[[(2S)-1-amino-3-methyl-1-oxo-pentan-2-yl]amino]-3-hydroxy-6-oxo-1-phenyl-5-(phenylmethyl)hexan-2-yl]carbamate
  • L-682, 679 analog 16

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus importin subunit beta 1 0.0103 0.0317 0.0313
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0039 0.0298
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0064 0.017 0.0165
Brugia malayi Transient-receptor-potential like protein 0.0033 0.0056 0.0148
Loa Loa (eye worm) hypothetical protein 0.0033 0.0056 0.0127
Brugia malayi RE40412p 0.0029 0.0039 0.01
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0087 0.0257 0.0253
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0083 0.0242 0.0238
Brugia malayi beta-lactamase 0.0037 0.0069 0.0187
Entamoeba histolytica hypothetical protein 0.0074 0.0208 0.1743
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0069 0.0225
Brugia malayi PHD-finger family protein 0.0027 0.0032 0.008
Loa Loa (eye worm) MH2 domain-containing protein 0.0207 0.0703 0.1729
Mycobacterium ulcerans oxidoreductase 0.0064 0.017 0.048
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0023 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0033 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.062 0.3501
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0242 0.1355
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Schistosoma mansoni hypothetical protein 0.0507 0.1825 0.1821
Brugia malayi Calcitonin receptor-like protein seb-1 0.0276 0.0962 0.2745
Echinococcus multilocularis neuropeptide receptor A26 0.0027 0.0033 0.0029
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0099 0.072
Brugia malayi Cathepsin L-like precursor 0.0333 0.1173 0.335
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0131 0.0127
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0203 0.0581
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0084 0.0244 0.1363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0099 0.0539
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0333 0.1173 0.6649
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0083 0.0242 0.1731
Brugia malayi CXXC zinc finger family protein 0.0216 0.0737 0.2101
Schistosoma mansoni hypothetical protein 0.0034 0.0057 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0043 0.0038
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0011 0.0077
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0083 0.0242 0.2038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0031 0.015
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0161
Brugia malayi Protein kinase domain containing protein 0.0044 0.0096 0.0264
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.0242 0.0683
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0039 0.0298
Schistosoma mansoni aldehyde dehydrogenase 0.0116 0.0365 0.0361
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0023 0.0018 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0097 0.0728
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0033 0.0029
Onchocerca volvulus 0.0027 0.0033 0.0192
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0083 0.0242 0.1355
Echinococcus granulosus cathepsin b 0.0954 0.3493 0.349
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.006 0.0154 0.041
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0034 0.0057 0.0052
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0097 0.0705
Loa Loa (eye worm) hypothetical protein 0.0064 0.017 0.0409
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0023 0.0018 0.0093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0333 0.1173 0.6649
Chlamydia trachomatis protoporphyrinogen oxidase 0.0064 0.017 1
Brugia malayi fibroinase precursor 0.0083 0.0242 0.0683
Schistosoma mansoni opsin-like receptor 0.0027 0.0033 0.0029
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0073 0.0589
Loa Loa (eye worm) ctsf protein 0.0333 0.1173 0.2893
Schistosoma mansoni aldehyde dehydrogenase 0.0116 0.0365 0.0361
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0039 0.0298
Echinococcus multilocularis tissue type plasminogen activator 0.0044 0.0096 0.0092
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0023 0.0018 0.0128
Giardia lamblia Hypothetical protein 0.0031 0.0048 0.0133
Entamoeba histolytica hypothetical protein 0.0074 0.0208 0.1743
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0242 0.0238
Echinococcus multilocularis dnaJ subfamily B 0.2698 1 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0181 0.0607 0.3432
Plasmodium vivax vivapain-1 0.0184 0.062 0.5266
Giardia lamblia Encystation-specific protease 0.0083 0.0242 0.1731
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.108 0.612
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0032 0.0155
Echinococcus multilocularis transient receptor potential gamma protein 0.009 0.0266 0.0262
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0064 0.017 0.048
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0069 0.0161
Mycobacterium ulcerans aldehyde dehydrogenase 0.0116 0.0365 0.1073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0242 0.1355
Schistosoma mansoni hypothetical protein 0.0029 0.0039 0.0035
Toxoplasma gondii peptidylprolyl isomerase 0.003 0.0044 0.0271
Onchocerca volvulus 0.0054 0.0131 0.1034
Brugia malayi hypothetical protein 0.0027 0.0033 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0184 0.062 0.4689
Brugia malayi cathepsin L-like cysteine proteinase 0.0083 0.0242 0.0683
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0033 0.0029
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0011 0.0039
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0055 0.0135 0.0131
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.006 0.0154 0.041
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0013 0.0078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0033 0.0029
Entamoeba histolytica cysteine protease, putative 0.0184 0.062 0.5266
Plasmodium vivax vivapain-2 0.0333 0.1173 1
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0181 0.0607 0.1713
Brugia malayi Uncoordinated protein 44 0.0034 0.0057 0.015
Schistosoma mansoni myosin xvIII 0.0027 0.0033 0.0029
Schistosoma mansoni cpg binding protein 0.0228 0.0783 0.0779
Echinococcus granulosus GPCR family 2 0.0087 0.0257 0.0253
Brugia malayi GnHR receptor homolog 0.0027 0.0033 0.0084
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0069 0.0176
Schistosoma mansoni cathepsin F (C01 family) 0.0333 0.1173 0.1169
Schistosoma mansoni calpain (C02 family) 0.0044 0.0097 0.0093
Plasmodium vivax calpain, putative 0.0044 0.0097 0.0794
Echinococcus multilocularis cathepsin b 0.0954 0.3493 0.349
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0069 0.0557
Echinococcus granulosus eukaryotic initiation factor 4A 0.0181 0.0607 0.0603
Onchocerca volvulus Glucosylceramidase homolog 0.0308 0.108 0.92
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0131 0.0127
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0027 0.0033 0.0029
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1678 0.6192 0.6191
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0302 0.0298
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0123 0.039 0.0386
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0203 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0064 0.017 0.0455
Echinococcus multilocularis cathepsin L cysteine protease 0.0333 0.1173 0.1169
Echinococcus granulosus enteropeptidase 0.0054 0.0131 0.0127
Echinococcus multilocularis somatostatin receptor 0.0027 0.0033 0.0029
Echinococcus multilocularis thyroid hormone receptor alpha 0.0119 0.0375 0.0371
Onchocerca volvulus 0.0099 0.0302 0.2504
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0184 0.062 0.0616
Brugia malayi Trypsin family protein 0.0054 0.0131 0.0364
Echinococcus granulosus tachykinin peptides receptor 99D 0.0027 0.0033 0.0029
Onchocerca volvulus 0.0037 0.0069 0.0501
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.009 0.0086
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.006 0.0154 0.1003
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0085 0.0249 0.0683
Brugia malayi Cathepsin L-like precursor 0.0101 0.0309 0.0872
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0479 0.1717 0.1714
Trypanosoma brucei importin beta-1 subunit, putative 0.0103 0.0317 0.2392
Entamoeba histolytica cysteine protease, putative 0.0184 0.062 0.5266
Trypanosoma cruzi cysteine peptidase, putative 0.0184 0.062 0.1748
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0099 0.0252
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.002 0.0004 0.0025
Brugia malayi jmjC domain containing protein 0.0023 0.0018 0.0039
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0203 0.17
Entamoeba histolytica acetyltransferase, GNAT family 0.0033 0.0054 0.0425
Mycobacterium leprae Conserved hypothetical protein 0.0031 0.0048 0.1934
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0203 0.17
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.0968 0.0964
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0131 0.0127
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0276 0.0962 0.2745
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.108 0.612
Brugia malayi calpain family protein 1 0.0118 0.037 0.1049
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0054 0.0131 0.0127
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0069 0.0167
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0083 0.0242 0.059
Echinococcus multilocularis Mastin 0.0054 0.0131 0.0127
Giardia lamblia Cathepsin L precursor 0.0083 0.0242 0.1731
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0069 0.0187
Schistosoma mansoni hypothetical protein 0.0027 0.0033 0.0029
Brugia malayi calpain family protein 1 0.0118 0.037 0.1049
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0152 0.0498 0.0494
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0333 0.1173 0.6649
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0104 0.0568
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.5633 0.5631
Schistosoma mansoni hypothetical protein 0.0189 0.0636 0.0632
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0203 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1173 0.6649
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0181 0.0607 0.0603
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0097 0.0247
Mycobacterium tuberculosis Possible oxidoreductase 0.0064 0.017 0.0551
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0333 0.1173 0.2893
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0372 0.132 1
Plasmodium vivax unspecified product 0.0101 0.0309 0.2604
Echinococcus granulosus serotonin receptor 0.0027 0.0033 0.0029
Echinococcus granulosus alpha 1A adrenergic receptor 0.0027 0.0033 0.0029
Schistosoma mansoni transient receptor potential channel 0.0059 0.0153 0.0148
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.003 0.0044 0.0302
Echinococcus granulosus short transient receptor potential channel 6 0.0059 0.0153 0.0149
Loa Loa (eye worm) hypothetical protein 0.0054 0.0131 0.0314
Toxoplasma gondii PfMNL-2 CISD1 family iron-sulfur protein, putative 0.0029 0.0039 0.0237
Giardia lamblia Cysteine protease 0.0083 0.0242 0.1731
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0033 0.0029
Schistosoma mansoni neuropeptide receptor 0.0027 0.0033 0.0029
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.003 0.0044 0.0095
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0134 0.0436
Schistosoma mansoni thyroid hormone receptor 0.0119 0.0375 0.0371
Echinococcus multilocularis dro:myosuppressin receptor 0.0027 0.0033 0.0029
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0083 0.0242 0.059
Entamoeba histolytica cysteine protease, putative 0.0184 0.062 0.5266
Onchocerca volvulus Cathepsin L homolog 0.0333 0.1173 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0016 0.0067
Onchocerca volvulus 0.0037 0.0069 0.0501
Loa Loa (eye worm) PHD-finger family protein 0.0027 0.0032 0.0069
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0033 0.0029
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0276 0.0962 0.2371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0032 0.0155
Schistosoma mansoni calpain-7 (C02 family) 0.0047 0.0106 0.0102
Brugia malayi hypothetical protein 0.0027 0.0033 0.0084
Loa Loa (eye worm) hypothetical protein 0.0064 0.017 0.0409
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0203 0.066
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0033 0.0029
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0461 0.0457
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.0242 0.0683
Schistosoma mansoni phosphatidylserine receptor 0.0023 0.0018 0.0014
Brugia malayi hypothetical protein 0.0027 0.0033 0.0084
Loa Loa (eye worm) hypothetical protein 0.0152 0.0498 0.1221
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Plasmodium falciparum protoporphyrinogen oxidase 0.0064 0.017 0.1415
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0043 0.0038
Brugia malayi CAAX amino terminal protease family protein 0.0085 0.0249 0.0702
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0033 0.0029
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0011 0.0036
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0027 0.0033 0.0192
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.005 0.0046
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0011 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0114 0.0624
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0033 0.0029
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0184 0.062 0.0616
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0027 0.0033 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0112 0.0349 0.0345
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0181 0.0607 0.0603
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0065 0.046
Trypanosoma brucei polo-like protein kinase 0.0093 0.028 0.2117
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0083 0.0242 0.059
Brugia malayi Importin beta-1 subunit 0.0103 0.0317 0.0895
Loa Loa (eye worm) hypothetical protein 0.0083 0.0242 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0029 0.0143
Schistosoma mansoni hypothetical protein 0.0074 0.0208 0.0204
Schistosoma mansoni amine GPCR 0.0027 0.0033 0.0029
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0054 0.0131 0.0127
Echinococcus granulosus tar DNA binding protein 0.0112 0.0349 0.0345
Echinococcus multilocularis short transient receptor potential channel 6 0.0059 0.0153 0.0148
Schistosoma mansoni cathepsin F (C01 family) 0.0333 0.1173 0.1169
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0181 0.0607 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0074 0.04
Trypanosoma brucei CAAX amino terminal protease, putative 0.0085 0.0249 0.1882
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Echinococcus multilocularis cathepsin L 0.0184 0.062 0.0616
Onchocerca volvulus 0.0027 0.0033 0.0192
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0083 0.0242 0.2038
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0033 0.0029
Plasmodium falciparum zinc finger protein, putative 0.0025 0.0026 0.019
Mycobacterium ulcerans glutaminase 0.049 0.1762 0.5301
Schistosoma mansoni hypothetical protein 0.0774 0.2819 0.2816
Leishmania major cathepsin L-like protease 0.0333 0.1173 0.8879
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.004 0.0204
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0083 0.0242 0.1355
Brugia malayi Dopamine receptor 0.0027 0.0033 0.0084
Echinococcus granulosus peregrin 0.003 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0099 0.0539
Echinococcus granulosus lysine specific histone demethylase 1A 0.0064 0.017 0.0165
Loa Loa (eye worm) latrophilin receptor protein 2 0.0087 0.0257 0.0627
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0029 0.0039 0.0298
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0017
Brugia malayi eukaryotic initiation factor 4A 0.0181 0.0607 0.1729
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0033 0.0029
Giardia lamblia Cathepsin B precursor 0.0083 0.0242 0.1731
Echinococcus granulosus JmjC domain containing protein 4 0.0023 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0073 0.0203 0.0492
Onchocerca volvulus 0.0027 0.0033 0.0192
Schistosoma mansoni tar DNA-binding protein 0.0112 0.0349 0.0345
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0114 0.0624
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0027 0.0032 0.0028
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0083 0.0242 0.1731
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0106 0.0326 0.0322
Loa Loa (eye worm) hypothetical protein 0.0083 0.0242 0.059
Mycobacterium ulcerans hypothetical protein 0.0031 0.0048 0.0112
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.006 0.0154 0.0429
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0242 0.1355
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0033 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0372 0.132 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0302 0.0853
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0131 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1173 0.6649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0022 0.01
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0308 0.0304
Entamoeba histolytica cysteine protease, putative 0.0083 0.0242 0.2038
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0069 0.0225
Brugia malayi acetyltransferase, GNAT family protein 0.0122 0.0386 0.1094
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0906 0.3314 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Brugia malayi jmjC domain containing protein 0.0023 0.0018 0.0039
Brugia malayi Telomerase reverse transcriptase 0.0226 0.0776 0.2213
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0069 0.0167
Echinococcus multilocularis snurportin 1 0.1102 0.4044 0.4042
Brugia malayi follicle stimulating hormone receptor 0.0027 0.0033 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0184 0.062 0.4689
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0203 0.0581
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0131 0.0127
Schistosoma mansoni calpain C (C02 family) 0.0044 0.0097 0.0093
Echinococcus multilocularis JmjC domain containing protein 4 0.0023 0.0018 0.0014
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0054 0.0131 0.0364
Echinococcus granulosus phd:f box containing protein 0.0023 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0203 0.0691 0.1699
Plasmodium vivax telomerase reverse transcriptase, putative 0.0085 0.0249 0.2093
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0034
Trypanosoma cruzi major cysteine proteinase, putative 0.0123 0.039 0.1088
Loa Loa (eye worm) hypothetical protein 0.0054 0.0134 0.0322
Entamoeba histolytica hypothetical protein 0.0083 0.0242 0.2038
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0073 0.0547
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0277 0.0964 0.096
Echinococcus granulosus g protein coupled receptor 0.0027 0.0033 0.0029
Brugia malayi Serotonin receptor 0.0027 0.0033 0.0084
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0027 0.0033 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.108 0.612
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0017
Echinococcus multilocularis calpain A 0.0123 0.039 0.0386
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.028 0.1571
Brugia malayi Cathepsin L-like precursor 0.0232 0.0796 0.2268
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0049 0.0114 0.0624
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0131 0.0127
Onchocerca volvulus 0.0029 0.0039 0.0241
Entamoeba histolytica cysteine protease, putative 0.0184 0.062 0.5266
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0032 0.0189
Loa Loa (eye worm) hypothetical protein 0.0061 0.0158 0.0381
Loa Loa (eye worm) hypothetical protein 0.0054 0.0134 0.0322
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.0033 0.0072
Entamoeba histolytica cysteine proteinase, putative 0.0184 0.062 0.5266
Leishmania major eukaryotic initiation factor 4a, putative 0.0181 0.0607 0.4583
Loa Loa (eye worm) DEAH box polypeptide 35 0.0481 0.1725 0.4259
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0049 0.0114 0.0624
Mycobacterium leprae Conserved hypothetical protein 0.0031 0.0048 0.1934
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.028 0.0773
Giardia lamblia Histone acetyltransferase GCN5 0.0033 0.0054 0.018
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0181 0.0607 0.3432
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0084 0.0244 0.1363
Schistosoma mansoni amine GPCR 0.0027 0.0033 0.0029
Echinococcus granulosus cathepsin l1 0.0333 0.1173 0.1169
Trichomonas vaginalis bromodomain-containing protein, putative 0.0036 0.0065 0.0346
Leishmania major UDP-galactopyranose mutase 0.0064 0.017 0.1256
Schistosoma mansoni patched 1 0.0043 0.009 0.0086
Loa Loa (eye worm) hypothetical protein 0.0056 0.0141 0.034
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0083 0.0242 0.1355
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0043 0.0038
Onchocerca volvulus 0.0049 0.0113 0.0877
Brugia malayi hypothetical protein 0.0027 0.0033 0.0084
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0087 0.0257 0.0726
Brugia malayi RE15519p 0.0027 0.0033 0.0084
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0068 0.0184 0.018
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0118 0.037 0.0366
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0116 0.0365 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0242 0.1355
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0073 0.0069
Brugia malayi TAR-binding protein 0.0112 0.0349 0.0989
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.028 0.2317
Loa Loa (eye worm) jmjC domain-containing protein 0.0023 0.0018 0.0034
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0131 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0044 0.0225
Onchocerca volvulus 0.0027 0.0033 0.0192
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0208 0.0204
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Loa Loa (eye worm) hypothetical protein 0.0073 0.0205 0.0496
Loa Loa (eye worm) hypothetical protein 0.0521 0.1875 0.463
Schistosoma mansoni opsin-like receptor 0.0027 0.0033 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0114 0.0624
Schistosoma mansoni growth hormone secretagogue receptor 0.0027 0.0033 0.0029
Echinococcus granulosus cathepsin L cysteine proteinase 0.0333 0.1173 0.1169
Schistosoma mansoni glutaminase 0.049 0.1762 0.1758
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.003 0.0044 0.0326
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0073 0.0197
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0083 0.0242 0.2038
Echinococcus granulosus cathepsin L 0.0083 0.0242 0.0238
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0083 0.0242 0.2038
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0083 0.0242 0.1355
Trichomonas vaginalis glucosylceramidase, putative 0.0469 0.1682 0.9545
Schistosoma mansoni ran 0.006 0.0154 0.015
Schistosoma mansoni ap endonuclease 0.0038 0.0073 0.0069
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0099 0.0095
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0085 0.0249 0.1394
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0372 0.132 1
Schistosoma mansoni hypothetical protein 0.0106 0.0326 0.0322
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0099 0.0811
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Brugia malayi Death domain containing protein 0.0034 0.0057 0.015
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0311 0.1094 0.9318
Brugia malayi Trypsin family protein 0.0054 0.0131 0.0364
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0011 0.0036
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Entamoeba histolytica CAAX prenyl protease family 0.0085 0.0249 0.2097
Echinococcus granulosus expressed protein 0.0031 0.0047 0.0042
Brugia malayi F/Y-rich N-terminus family protein 0.0076 0.0214 0.0601
Echinococcus multilocularis netrin receptor unc 5 0.0034 0.0057 0.0052
Giardia lamblia Cathepsin B precursor 0.0083 0.0242 0.1731
Brugia malayi glutaminase DH11.1 0.049 0.1762 0.5038
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0054 0.0131 0.0314
Echinococcus granulosus g protein coupled receptor 0.0027 0.0033 0.0029
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0027 0.0033 0.0029
Trypanosoma cruzi cysteine peptidase, putative 0.0372 0.132 0.376
Schistosoma mansoni ran 0.006 0.0154 0.015
Mycobacterium ulcerans hypothetical protein 0.0037 0.0069 0.0176
Echinococcus granulosus TRP transient receptor potential channel 0.0033 0.0056 0.0052
Echinococcus granulosus sex peptide receptor 0.0027 0.0033 0.0029
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.0033 0.0072
Echinococcus multilocularis short transient receptor potential channel 6 0.0059 0.0153 0.0149
Plasmodium vivax vivapain-3 0.0184 0.062 0.5266
Loa Loa (eye worm) RNA binding protein 0.0112 0.0349 0.0854
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0027 0.0033 0.0029
Trypanosoma cruzi cysteine peptidase, putative 0.0372 0.132 0.376
Schistosoma mansoni transient receptor potential channel 0.009 0.0266 0.0262
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0181 0.0607 0.3432
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0333 0.1173 0.6649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0242 0.1355
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0011 0.002
Brugia malayi G-protein coupled receptor 0.0027 0.0033 0.0084
Echinococcus multilocularis phd:f box containing protein 0.0023 0.0018 0.0014
Mycobacterium leprae Probable lipase LipE 0.0037 0.0069 0.3038
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0011 0.0039
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0027 0.0033 0.0029
Echinococcus multilocularis conserved hypothetical protein 0.0029 0.0039 0.0035
Brugia malayi PHD-finger family protein 0.0021 0.001 0.0017
Brugia malayi hypothetical protein 0.0027 0.0033 0.0084
Schistosoma mansoni hypothetical protein 0.0087 0.0257 0.0253
Giardia lamblia Hypothetical protein 0.0083 0.0242 0.1731
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0083 0.0242 0.2038
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.0302 0.0298
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0073 0.0392
Loa Loa (eye worm) fibroinase 0.0333 0.1173 0.2893
Brugia malayi hypothetical protein 0.0027 0.0033 0.0084
Brugia malayi hypothetical protein 0.0239 0.0821 0.2343
Brugia malayi Dopamine receptor protein 1 0.0027 0.0033 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0022 0.01
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0033 0.0072
Leishmania major importin beta-1 subunit, putative 0.0084 0.0244 0.182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1173 0.6649
Loa Loa (eye worm) hypothetical protein 0.0054 0.0131 0.0314
Schistosoma mansoni hypothetical protein 0.0027 0.0033 0.0029
Echinococcus granulosus Transglutaminase 0.0031 0.0048 0.0044
Plasmodium vivax RNA helicase-1, putative 0.0181 0.0607 0.5162
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0083 0.0242 0.1355
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0181 0.0607 0.1713
Schistosoma mansoni hypothetical protein 0.0027 0.0032 0.0028
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0033 0.0072
Trichomonas vaginalis helicase, putative 0.0049 0.0114 0.0624
Echinococcus granulosus nuclear factor of activated T cells 5 0.0328 0.1155 0.1151
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0029 0.0143
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0099 0.0743
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0033 0.0029
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0099 0.0095
Leishmania major telomerase reverse transcriptase, putative 0.0085 0.0249 0.1858
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0069 0.0225
Schistosoma mansoni adenoreceptor 0.0027 0.0033 0.0029
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0077 0.0219 0.146
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0027 0.0033 0.0029
Mycobacterium ulcerans hypothetical protein 0.0073 0.0203 0.0581
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0203 0.17
Echinococcus granulosus g-protein coupled receptor 0.0027 0.0033 0.0029
Trypanosoma cruzi importin beta-1 subunit, putative 0.0084 0.0244 0.0668
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0011 0.002
Entamoeba histolytica cysteine proteinase 1, putative 0.0184 0.062 0.5266
Echinococcus granulosus transient receptor potential ion channel A 0.0087 0.0255 0.025
Brugia malayi cathepsin Z-like cysteine proteinase 0.0083 0.0242 0.0683
Brugia malayi Cathepsin L-like precursor 0.0333 0.1173 0.335
Brugia malayi Tachykinin-like peptides receptor 99D 0.0027 0.0033 0.0084
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0011 0.002
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0954 0.3493 0.349
Onchocerca volvulus 0.0054 0.0131 0.1034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Schistosoma mansoni cathepsin s 0.0101 0.0309 0.0304
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0333 0.1173 0.6649
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Trichomonas vaginalis rotamase, putative 0.003 0.0044 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0114 0.0624
Schistosoma mansoni cathepsin C 0.0083 0.0242 0.0238
Schistosoma mansoni hypothetical protein 0.0044 0.0096 0.0092
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0085 0.0249 0.0684
Toxoplasma gondii zinc finger cdgsh type protein 0.0029 0.0039 0.0237
Echinococcus granulosus mixed lineage leukemia protein mll 0.0055 0.0135 0.0131
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0302 0.2548
Echinococcus multilocularis calpain 5 0.0044 0.0097 0.0093
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0131 0.0127
Leishmania major cathepsin L-like protease 0.0372 0.132 1
Echinococcus granulosus neuropeptide receptor 0.0027 0.0033 0.0029
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0097 0.0247
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0031 0.0047 0.0105
Onchocerca volvulus 0.0204 0.0692 0.5863
Schistosoma mansoni alpha-1 adrenergic receptor 0.0027 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0052 0.0126 0.0302
Onchocerca volvulus 0.0064 0.017 0.1364
Plasmodium falciparum cysteine proteinase falcipain 3 0.0333 0.1173 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0954 0.3493 1
Onchocerca volvulus 0.0027 0.0033 0.0192
Schistosoma mansoni cpg binding protein 0.0228 0.0783 0.0779
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0027 0.0033 0.0084
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0479 0.1717 0.1714
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0033 0.0029
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0104 0.0568
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0122 0.0386 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0083 0.0242 0.1355
Trichomonas vaginalis glucosylceramidase, putative 0.0469 0.1682 0.9545
Schistosoma mansoni neuropeptide receptor 0.0027 0.0033 0.0029
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0069 0.0518
Giardia lamblia Hypothetical protein 0.0085 0.0249 0.1787
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0033 0.0029
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0011 0.0007
Toxoplasma gondii histone lysine-specific demethylase 0.0064 0.017 0.1126
Echinococcus granulosus cpg binding protein 0.0228 0.0783 0.0779
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0036 0.0065 0.052
Leishmania major cathepsin L-like protease 0.0333 0.1173 0.8879
Leishmania major cathepsin L-like protease 0.0372 0.132 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0131 0.0127
Giardia lamblia Cathepsin L precursor 0.0083 0.0242 0.1731
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1173 0.6649
Schistosoma mansoni hypothetical protein 0.0054 0.0131 0.0127
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0011 0.0052
Onchocerca volvulus 0.0027 0.0033 0.0192
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0161
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0954 0.3493 0.349
Brugia malayi latrophilin 2 splice variant baaae 0.0189 0.0636 0.181
Loa Loa (eye worm) hypothetical protein 0.0027 0.0032 0.0069
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0123 0.04
Plasmodium falciparum cysteine repeat modular protein 1 0.0044 0.0096 0.0788
Trypanosoma brucei antigen, putative 0.0044 0.0097 0.0728
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.1102 0.4044 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0083 0.0242 0.2038
Trypanosoma cruzi cruzipain precursor, putative 0.0101 0.0309 0.0854
Entamoeba histolytica cysteine protease, putative 0.0083 0.0242 0.2038
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0184 0.062 0.0616
Onchocerca volvulus Alhambra homolog 0.0027 0.0032 0.018
Onchocerca volvulus 0.0152 0.0498 0.4189
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0033 0.0029
Brugia malayi neuropeptide F receptor 0.0027 0.0033 0.0084
Brugia malayi Cathepsin L-like precursor 0.0333 0.1173 0.335
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0097 0.0728
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0459 0.1644 0.1641
Echinococcus multilocularis sex peptide receptor 0.0027 0.0033 0.0029
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0333 0.1173 0.1169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0016 0.0067
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0242 0.0238
Echinococcus granulosus transmembrane protease serine 3 0.0054 0.0131 0.0127
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0083 0.0242 0.2038
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0054 0.0131 0.0127
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0203 0.0569
Brugia malayi ORL1-like opioid receptor 0.0027 0.0033 0.0084
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0181 0.0607 0.5133
Leishmania major hypothetical protein, conserved 0.0037 0.0069 0.0495
Onchocerca volvulus 0.0044 0.0096 0.0733
Trichomonas vaginalis glucosylceramidase, putative 0.0469 0.1682 0.9545
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0011 0.0036
Onchocerca volvulus Netrin receptor homolog 0.0034 0.0057 0.0391
Schistosoma mansoni hypothetical protein 0.0027 0.0033 0.0029
Schistosoma mansoni hypothetical protein 0.0087 0.0257 0.0253
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.006 0.0154 0.0371
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0011 0.0047
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0032 0.0238
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Brugia malayi cathepsin F-like cysteine proteinase 0.0101 0.0309 0.0872
Brugia malayi RNA recognition motif domain containing protein 0.0112 0.0349 0.0989
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0083 0.0242 0.2038
Trichomonas vaginalis peptide N-glycanase, putative 0.0031 0.0048 0.025
Plasmodium vivax importin-beta 2, putative 0.0103 0.0317 0.2673
Echinococcus granulosus neuropeptide FF receptor 2 0.0027 0.0033 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0047 0.0242
Echinococcus multilocularis GTP binding nuclear protein Ran 0.006 0.0154 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0056 0.0295
Brugia malayi larval opioid receptor 0.0027 0.0033 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1173 0.6649
Onchocerca volvulus 0.0216 0.0737 0.6251
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0271 0.0943 0.2677
Echinococcus multilocularis neuropeptide s receptor 0.0027 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0099 0.0302 0.0737
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0073 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0139 0.0334
Schistosoma mansoni cathepsin F (C01 family) 0.0232 0.0796 0.0792
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.009 0.0086
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0033 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1173 0.6649
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0097 0.0705
Plasmodium falciparum histone acetyltransferase GCN5 0.0033 0.0054 0.0425
Brugia malayi hypothetical protein 0.0027 0.0033 0.0084
Brugia malayi Muscleblind-like protein 0.0521 0.1875 0.5361
Mycobacterium tuberculosis Conserved hypothetical protein 0.0031 0.0048 0.0157
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.0302 0.0298
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0161
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0073 0.0238
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0073 0.0392
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0064 0.017 0.0165
Echinococcus granulosus cathepsin l1 0.0232 0.0796 0.0792
Mycobacterium tuberculosis Conserved protein 0.0037 0.0069 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1173 0.6649
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0027 0.0033 0.0029
Plasmodium falciparum phd finger protein, putative 0.0027 0.0032 0.0238
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0087 0.0257 0.0253
Trichomonas vaginalis glucosylceramidase, putative 0.0324 0.1142 0.6472
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0143 0.0464 0.046
Onchocerca volvulus 0.0054 0.0131 0.1034
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0069 0.3038
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0203 0.0581
Giardia lamblia Cathepsin B precursor 0.0353 0.1248 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0073 0.0188
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0114 0.0624
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0011 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0353 0.1248 0.7076
Echinococcus multilocularis protoporphyrinogen oxidase 0.0064 0.017 0.0165
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0123 0.039 0.0386
Toxoplasma gondii kringle domain-containing protein 0.0044 0.0096 0.0627
Trichomonas vaginalis hypothetical protein 0.0026 0.0029 0.0143
Brugia malayi amine oxidase, flavin-containing family protein 0.0064 0.017 0.0474
Schistosoma mansoni jumonji domain containing protein 0.0124 0.0396 0.0392
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0277 0.0964 0.096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0372 0.132 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0064 0.017 0.0165
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0507 0.1825 0.1821
Plasmodium falciparum eukaryotic initiation factor 4A 0.0181 0.0607 0.5162
Entamoeba histolytica cysteine proteinase, putative 0.0333 0.1173 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0277 0.0964 0.096
Loa Loa (eye worm) hypothetical protein 0.0954 0.3493 0.8636
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0085 0.0249 0.1862
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Echinococcus multilocularis expressed conserved protein 0.0093 0.0279 0.0275
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0033 0.0072
Brugia malayi calpain 7 0.0044 0.0097 0.0266
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0055 0.0135 0.0131
Entamoeba histolytica Ran family GTPase 0.006 0.0154 0.1281
Echinococcus granulosus neuropeptide s receptor 0.0027 0.0033 0.0029
Brugia malayi G protein-coupled receptor 0.0027 0.0033 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0242 0.1355
Echinococcus multilocularis microtubule associated protein 2 0.1853 0.6846 0.6845
Giardia lamblia Cathepsin L precursor 0.0083 0.0242 0.1731
Echinococcus granulosus somatostatin receptor 0.0027 0.0033 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.0796 0.4503
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.006 0.0154 0.1281
Loa Loa (eye worm) hypothetical protein 0.0043 0.009 0.0213
Brugia malayi hypothetical protein 0.0027 0.0033 0.0084
Schistosoma mansoni biogenic amine receptor 0.0027 0.0033 0.0029
Schistosoma mansoni jumonji domain containing protein 0.0023 0.0018 0.0014
Echinococcus granulosus neuropeptide receptor 0.0027 0.0033 0.0029
Schistosoma mansoni amine GPCR 0.0027 0.0033 0.0029
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0027 0.0033 0.0084
Brugia malayi Bromodomain containing protein 0.003 0.0043 0.0112
Loa Loa (eye worm) beta-lactamase 0.0037 0.0069 0.0161
Echinococcus multilocularis cysteine protease 0.0333 0.1173 0.1169
Trypanosoma brucei importin beta-1 subunit, putative 0.0103 0.0317 0.2392
Echinococcus multilocularis cysteine protease 0.0333 0.1173 0.1169
Entamoeba histolytica cysteine protease, putative 0.0184 0.062 0.5266
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0112 0.0349 0.0854
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Loa Loa (eye worm) hypothetical protein 0.0087 0.0255 0.062
Trypanosoma cruzi kinesin, putative 0.0031 0.0047 0.0104
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0033 0.0029
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0033 0.0029
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0843 0.3076 1
Brugia malayi Serotonin receptor 0.0027 0.0033 0.0084
Echinococcus multilocularis expressed protein 0.0031 0.0047 0.0042
Trypanosoma cruzi kinesin, putative 0.0031 0.0047 0.0104
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Loa Loa (eye worm) hypothetical protein 0.0083 0.0242 0.059
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0469 0.1682 0.4808
Schistosoma mansoni tar DNA-binding protein 0.0112 0.0349 0.0345
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0033 0.0029
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0099 0.0235
Loa Loa (eye worm) trypsin family protein 0.0054 0.0131 0.0314
Entamoeba histolytica cysteine protease, putative 0.0333 0.1173 1
Schistosoma mansoni histamine h1 receptor 0.0027 0.0033 0.0029
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0069 0.0225
Echinococcus granulosus netrin receptor unc 5 0.0034 0.0057 0.0052
Loa Loa (eye worm) hypothetical protein 0.009 0.0266 0.0647
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0083 0.0242 0.0683
Schistosoma mansoni hypothetical protein 0.0087 0.0257 0.0253
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0011 0.0036
Giardia lamblia Cathepsin L-like protease 0.0083 0.0242 0.1731
Loa Loa (eye worm) hypothetical protein 0.0054 0.0134 0.0322
Loa Loa (eye worm) hypothetical protein 0.0054 0.0134 0.0322
Plasmodium vivax hypothetical protein, conserved 0.0064 0.017 0.1415
Plasmodium falciparum serine repeat antigen 1 0.0083 0.0242 0.2038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0277 0.0964 0.096
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0181 0.0607 0.0603
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0033 0.0056 0.0052
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0011 0.002
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0033 0.0029
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0033 0.0029
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0011 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0022 0.01
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0073 0.017
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0203 0.0581
Plasmodium vivax SET domain protein, putative 0.003 0.0043 0.0328
Echinococcus multilocularis PHD finger protein rhinoceros 0.0027 0.0032 0.0028
Echinococcus granulosus jumonji domain containing protein 0.0038 0.0071 0.0067
Loa Loa (eye worm) oxidoreductase 0.0021 0.0011 0.0017
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0161 0.0532 0.4481
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0044 0.0097 0.0247
Giardia lamblia Cysteine protease 0.0083 0.0242 0.1731
Leishmania major eukaryotic initiation factor 4a, putative 0.0181 0.0607 0.4583
Entamoeba histolytica hypothetical protein 0.0084 0.0244 0.205
Echinococcus multilocularis 0.0064 0.017 0.0165
Brugia malayi Trypsin family protein 0.0152 0.0498 0.1414
Echinococcus multilocularis Transglutaminase 0.0031 0.0048 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0114 0.0624
Schistosoma mansoni amine oxidase 0.0064 0.017 0.0165
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0033 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0022 0.01
Echinococcus granulosus peptide allatostatin:somatostatin 0.0027 0.0033 0.0029
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0011 0.0073
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0064 0.017 0.8265
Echinococcus granulosus microtubule associated protein 2 0.1853 0.6846 0.6845
Loa Loa (eye worm) hypothetical protein 0.0054 0.0131 0.0314
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0106 0.0326 0.0322
Echinococcus granulosus orexin receptor type 2 0.0027 0.0033 0.0029
Echinococcus multilocularis enteropeptidase 0.0054 0.0131 0.0127
Onchocerca volvulus 0.0073 0.0205 0.1667
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0043 0.0038
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0086
Loa Loa (eye worm) calpain 0.0044 0.0097 0.023
Loa Loa (eye worm) hypothetical protein 0.0101 0.0309 0.0753
Schistosoma mansoni opsin-like receptor 0.0027 0.0033 0.0029
Echinococcus granulosus calpain A 0.0123 0.039 0.0386
Toxoplasma gondii preprocathepsin c precursor, putative 0.0083 0.0242 0.1622
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0027 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0054 0.0134 0.0322
Entamoeba histolytica cysteine protease, putative 0.0184 0.062 0.5266
Schistosoma mansoni ankyrin 23/unc44 0.0034 0.0057 0.0052
Echinococcus granulosus short transient receptor potential channel 6 0.0059 0.0153 0.0148
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.028 0.1571
Schistosoma mansoni cpg binding protein 0.0216 0.0737 0.0733
Schistosoma mansoni transient receptor potential channel 0.0059 0.0153 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1173 0.6649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1173 0.6649
Plasmodium falciparum serine repeat antigen 5 0.0083 0.0242 0.2038
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0954 0.3493 0.349
Echinococcus granulosus muscleblind protein 0.0521 0.1875 0.1871
Toxoplasma gondii cathepsin CPL 0.0333 0.1173 0.7957
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0096 0.0245
Echinococcus multilocularis Ankyrin 0.0034 0.0057 0.0053
Leishmania major cathepsin L-like protease 0.0333 0.1173 0.8879
Onchocerca volvulus 0.0333 0.1173 1
Brugia malayi jmjC domain containing protein 0.0023 0.0018 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0065 0.0344
Trichomonas vaginalis set domain proteins, putative 0.0204 0.0692 0.3912
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0097 0.0728
Entamoeba histolytica cysteine proteinase, putative 0.0184 0.062 0.5266
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0055 0.0135 0.0131
Loa Loa (eye worm) calpain 5 0.0031 0.0047 0.0106
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0372 0.132 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0086
Trypanosoma cruzi cysteine peptidase, putative 0.0333 0.1173 0.3336
Leishmania major cathepsin L-like protease 0.0372 0.132 1
Leishmania major GTP-binding protein, putative 0.006 0.0154 0.1138
Loa Loa (eye worm) glutaminase 0.049 0.1762 0.435
Mycobacterium tuberculosis Conserved protein 0.0037 0.0069 0.0225
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0033 0.0029
Schistosoma mansoni calpain-7 (C02 family) 0.0047 0.0106 0.0102
Loa Loa (eye worm) hypothetical protein 0.0099 0.0302 0.0737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0242 0.1355
Onchocerca volvulus 0.0054 0.0131 0.1034
Giardia lamblia Cathepsin L precursor 0.0083 0.0242 0.1731
Loa Loa (eye worm) TAR-binding protein 0.0112 0.0349 0.0854
Entamoeba histolytica cysteine proteinase, putative 0.0184 0.062 0.5266
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0181 0.0607 0.1975
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0065 0.0344
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0112 0.0349 0.0345
Brugia malayi Pre-SET motif family protein 0.018 0.0602 0.1712
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0372 0.132 1
Echinococcus granulosus geminin 0.0774 0.2819 0.2816
Onchocerca volvulus Neuropeptide F receptor homolog 0.0027 0.0033 0.0192
Echinococcus granulosus neuropeptide receptor A26 0.0027 0.0033 0.0029
Brugia malayi Dopamine receptor protein 2 0.0027 0.0033 0.0084
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0099 0.072
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0161
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0161
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0011 0.0047
Loa Loa (eye worm) transcription factor SMAD2 0.0207 0.0703 0.1729
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0333 0.1173 0.2893
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0033 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0027 0.0033 0.0029
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0064 0.017 0.1415
Entamoeba histolytica hypothetical protein 0.0074 0.0208 0.1743
Trichomonas vaginalis ran, putative 0.006 0.0154 0.0852
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0083 0.0242 0.2038
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0011 0.0007
Onchocerca volvulus 0.0098 0.0298 0.2468
Plasmodium vivax unspecified product 0.0184 0.062 0.5266
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0011 0.0059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0027 0.0033 0.0072
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0131 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1173 0.6649
Entamoeba histolytica cysteine protease, putative 0.0184 0.062 0.5266
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0069 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0016 0.0067
Schistosoma mansoni neuropeptide f receptor 76f 0.0027 0.0033 0.0029
Brugia malayi MH2 domain containing protein 0.0207 0.0703 0.2002
Echinococcus multilocularis jumonji domain containing protein 0.0038 0.0071 0.0067
Schistosoma mansoni hypothetical protein 0.2698 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0116 0.0365 0.1188
Onchocerca volvulus 0.0083 0.0242 0.1992
Brugia malayi hypothetical protein 0.0064 0.017 0.0474
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.0033 0.0072
Schistosoma mansoni ap endonuclease 0.0038 0.0073 0.0069
Echinococcus granulosus GTP binding nuclear protein Ran 0.006 0.0154 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.009 0.049
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0184 0.062 0.1748
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0097 0.0728
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0032 0.0155
Plasmodium falciparum serine repeat antigen 6 0.0083 0.0242 0.2038
Toxoplasma gondii exonuclease III APE 0.0038 0.0073 0.0469
Echinococcus granulosus glycoprotein Antigen 5 0.0054 0.0131 0.0127
Echinococcus multilocularis muscleblind protein 0.0521 0.1875 0.1871
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0033 0.0029
Schistosoma mansoni cathepsin B (C01 family) 0.0083 0.0242 0.0238
Giardia lamblia Cathepsin L precursor 0.0083 0.0242 0.1731
Echinococcus multilocularis cathepsin L cysteine protease 0.0333 0.1173 0.1169
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0033 0.0029
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0083 0.0242 0.2038
Mycobacterium tuberculosis Conserved protein 0.0037 0.0069 0.0225
Entamoeba histolytica cysteine proteinase, putative 0.0333 0.1173 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0024 0.0022 0.0017
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0181 0.0607 0.5162
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0033 0.0029
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0073 0.0589
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.003 0.0044 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Loa Loa (eye worm) hypothetical protein 0.0103 0.0317 0.0773
Loa Loa (eye worm) hypothetical protein 0.0181 0.0607 0.1493
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0242 0.0238
Echinococcus granulosus calpain 7 C02 family 0.0044 0.0097 0.0093
Mycobacterium tuberculosis Conserved protein 0.0031 0.0048 0.0157
Trypanosoma cruzi cysteine proteinase, putative 0.0184 0.062 0.1748
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.108 0.612
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0101 0.0309 0.0872
Trichomonas vaginalis glucosylceramidase, putative 0.0324 0.1142 0.6472
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0069 0.0065
Brugia malayi G-protein coupled receptor 0.0027 0.0033 0.0084
Schistosoma mansoni myst-related protein 0.0025 0.0026 0.0022
Giardia lamblia Cathepsin B precursor 0.0083 0.0242 0.1731
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0069 0.0065
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0085 0.0249 0.0245
Entamoeba histolytica cysteine protease, putative 0.0184 0.062 0.5266
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0203 0.1509
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0181 0.0607 0.4733
Echinococcus multilocularis tar DNA binding protein 0.0112 0.0349 0.0345
Echinococcus multilocularis neuropeptide FF receptor 2 0.0027 0.0033 0.0029
Trypanosoma cruzi cruzipain precursor, putative 0.0372 0.132 0.376
Loa Loa (eye worm) histone methyltransferase 0.0068 0.0184 0.0445
Echinococcus multilocularis geminin 0.0774 0.2819 0.2816
Giardia lamblia Cysteine protease 0.0083 0.0242 0.1731
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.028 0.1571
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0203 0.0581
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0242 0.1355
Loa Loa (eye worm) hypothetical protein 0.0087 0.0257 0.0627
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0027 0.0033 0.0029
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0011 0.0036
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0011 0.0059
Brugia malayi hypothetical protein 0.0027 0.0033 0.0084
Brugia malayi hypothetical protein 0.0054 0.0131 0.0364
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0083 0.0242 0.2038
Schistosoma mansoni biogenic amine receptor 0.0027 0.0033 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0372 0.132 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0116 0.0365 0.1073
Trypanosoma cruzi cysteine protease, putative 0.0184 0.062 0.1748
Schistosoma mansoni amine GPCR 0.0027 0.0033 0.0029
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0203 0.0691 0.1967
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0064 0.017 0.1415
Schistosoma mansoni hypothetical protein 0.1102 0.4044 0.4042
Echinococcus granulosus expressed conserved protein 0.0093 0.0279 0.0275
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0203 0.066
Onchocerca volvulus 0.0333 0.1173 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0036 0.0065 0.0346
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0073 0.0178
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Echinococcus granulosus histone acetyltransferase KAT2B 0.0118 0.0373 0.0369
Plasmodium vivax hypothetical protein, conserved 0.0064 0.017 0.1415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0099 0.0539
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.108 0.612
Plasmodium falciparum cysteine proteinase falcipain 1 0.0184 0.062 0.5266
Echinococcus granulosus calpain A 0.0044 0.0097 0.0093
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.006 0.0154 0.116
Schistosoma mansoni tar DNA-binding protein 0.0112 0.0349 0.0345
Schistosoma mansoni hypothetical protein 0.0041 0.0085 0.008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0123 0.04
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0033 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0069 0.037
Giardia lamblia Hypothetical protein 0.0083 0.0242 0.1731
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0083 0.0242 0.2038
Giardia lamblia Cathepsin L precursor 0.0083 0.0242 0.1731
Plasmodium falciparum JmjC domain-containing protein, putative 0.0023 0.0018 0.0117
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0208 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0056 0.0295
Echinococcus multilocularis g-protein coupled receptor 0.0027 0.0033 0.0029
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0064 0.017 0.1415
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.0821 0.0818
Loa Loa (eye worm) hypothetical protein 0.0083 0.0242 0.059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Echinococcus granulosus cathepsin b 0.0954 0.3493 0.349
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0083 0.0242 0.1731
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0123 0.04
Leishmania major hypothetical protein, conserved 0.0023 0.0018 0.0104
Plasmodium falciparum serine repeat antigen 7 0.0083 0.0242 0.2038
Brugia malayi Latrophilin receptor protein 2 0.0087 0.0257 0.0726
Echinococcus multilocularis protein patched 0.0043 0.009 0.0086
Echinococcus multilocularis GPCR, family 2 0.0087 0.0257 0.0253
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0116 0.0365 0.0361
Echinococcus multilocularis glycoprotein Antigen 5 0.0054 0.0131 0.0127
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0011 0.0036
Schistosoma mansoni biogenic amine receptor 0.0027 0.0033 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0242 0.1355
Toxoplasma gondii HEAT repeat-containing protein 0.0103 0.0317 0.2127
Leishmania major cathepsin L-like protease 0.0333 0.1173 0.8879
Loa Loa (eye worm) calpain family protein 1 0.0118 0.037 0.0906
Loa Loa (eye worm) hypothetical protein 0.0083 0.0242 0.059
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0083 0.0242 0.1355
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0143 0.0464 0.046
Brugia malayi cathepsin L precursor 0.0083 0.0242 0.0683
Plasmodium falciparum serine repeat antigen 4 0.0083 0.0242 0.2038
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.009 0.0213
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.006 0.0154 0.1281
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0131 0.0127
Brugia malayi hypothetical protein 0.0074 0.0208 0.0584
Echinococcus multilocularis cathepsin L 0.0083 0.0242 0.0238
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0034 0.0057 0.0129
Onchocerca volvulus 0.0333 0.1173 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0083 0.0242 0.0664
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.017 0.0551
Toxoplasma gondii cathepsin CPC1 0.0083 0.0242 0.1622
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0027 0.0033 0.0029
Onchocerca volvulus 0.0333 0.1173 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0333 0.1173 0.6649
Loa Loa (eye worm) hypothetical protein 0.0064 0.017 0.0409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0022 0.01
Leishmania major cathepsin L-like protease 0.0333 0.1173 0.8879
Schistosoma mansoni thyroid hormone receptor 0.0119 0.0375 0.0371
Brugia malayi cathepsin Z-like cysteine proteinase 0.0083 0.0242 0.0683
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0083 0.0242 0.1731
Brugia malayi Probable ATP-dependent helicase DHX35 0.0481 0.1725 0.4932
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0277 0.0964 0.2375
Schistosoma mansoni hypothetical protein 0.0049 0.0113 0.0109
Plasmodium falciparum serine repeat antigen 3 0.0083 0.0242 0.2038
Schistosoma mansoni survival motor neuron protein 0.0049 0.0113 0.0109
Echinococcus granulosus 7tm_1 domain containing protein 0.0027 0.0033 0.0029
Schistosoma mansoni myst-related protein 0.0025 0.0026 0.0022
Echinococcus granulosus allatostatin A receptor 0.0027 0.0033 0.0029
Schistosoma mansoni rotamase 0.0031 0.0047 0.0042
Loa Loa (eye worm) hypothetical protein 0.0161 0.0532 0.1306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0033 0.0029
Brugia malayi Cathepsin L-like precursor 0.0333 0.1173 0.335
Echinococcus granulosus lysine specific demethylase 5A 0.0099 0.0302 0.0298
Giardia lamblia GTOR 0.0045 0.0099 0.0551
Leishmania major kinesin, putative 0.0031 0.0047 0.0326
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0097 0.0247
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0097 0.0247
Schistosoma mansoni microtubule-associated protein tau 0.1853 0.6846 0.6845
Schistosoma mansoni transient receptor potential channel 4 0.009 0.0266 0.0262
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0131 0.0127
Brugia malayi Kringle domain containing protein 0.0044 0.0096 0.0264
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0099 0.0252
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0113 0.0312
Brugia malayi RE40412p 0.0029 0.0039 0.01
Onchocerca volvulus 0.0203 0.0691 0.585
Loa Loa (eye worm) hypothetical protein 0.0073 0.0203 0.0492
Loa Loa (eye worm) hypothetical protein 0.0276 0.0962 0.2371
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.003 0.0044 0.034
Loa Loa (eye worm) cysteine protease 0.0333 0.1173 0.2893
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0011 0.0036
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0099 0.0811
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0073 0.0178
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0031 0.0047 0.0122
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0203 0.0581
Plasmodium falciparum telomerase reverse transcriptase 0.0085 0.0249 0.2093
Loa Loa (eye worm) hypothetical protein 0.0064 0.017 0.0409
Mycobacterium ulcerans beta-lactamase 0.0037 0.0069 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.028 0.1571
Echinococcus multilocularis allatostatin A receptor 0.0027 0.0033 0.0029
Toxoplasma gondii aldehyde dehydrogenase 0.0116 0.0365 0.2459
Plasmodium falciparum importin beta, putative 0.0103 0.0317 0.2673
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Loa Loa (eye worm) hypothetical protein 0.0044 0.0096 0.0228
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0097 0.0728
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Echinococcus granulosus fmrfamide receptor 0.0027 0.0033 0.0029
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0044 0.0097 0.0728
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0114 0.0624
Brugia malayi RNA binding protein 0.0112 0.0349 0.0989
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0027 0.0033 0.0029
Echinococcus multilocularis lysine specific demethylase 5A 0.0087 0.0256 0.0252
Loa Loa (eye worm) cathepsin B 0.0353 0.1248 0.3078
Echinococcus granulosus cysteine protease 0.0184 0.062 0.0616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1173 0.6649
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0242 0.1355
Trichomonas vaginalis glutaminase, putative 0.049 0.1762 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0333 0.1173 0.1169
Toxoplasma gondii zinc finger CDGSH-type domain-containing protein 0.0029 0.0039 0.0237
Echinococcus granulosus Mastin 0.0054 0.0131 0.0127
Loa Loa (eye worm) jmjC domain-containing protein 0.0023 0.0018 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1173 0.6649
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0333 0.1173 0.6649
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0085 0.0249 0.0245
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0134 0.1112
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0033 0.0029
Echinococcus multilocularis CAAX prenyl protease 2 0.0085 0.0249 0.0245
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0097 0.0247
Echinococcus granulosus G protein coupled receptor 139 0.0027 0.0033 0.0029
Brugia malayi cathepsin F-like cysteine proteinase 0.0083 0.0242 0.0683
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.028 0.2362
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.0309 0.0854
Echinococcus granulosus histone acetyltransferase KAT2B 0.0036 0.0065 0.0061
Schistosoma mansoni hypothetical protein 0.0087 0.0257 0.0253
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.0821 0.0818
Entamoeba histolytica cysteine protease, putative 0.0184 0.062 0.5266
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0333 0.1173 0.1169
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Brugia malayi jmjC domain containing protein 0.0023 0.0018 0.0039
Onchocerca volvulus Cathepsin F homolog 0.0333 0.1173 1
Echinococcus multilocularis hypothetical protein 0.0044 0.0097 0.0093
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0131
Giardia lamblia Cysteine protease 0.0083 0.0242 0.1731
Mycobacterium ulcerans monoamine oxidase 0.0064 0.017 0.048
Schistosoma mansoni importin beta-1 0.0103 0.0317 0.0313
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0085 0.0249 0.0683
Brugia malayi G protein-coupled receptor F59B2.13 0.0027 0.0033 0.0084
Onchocerca volvulus 0.0031 0.0048 0.0319
Brugia malayi Immunoglobulin I-set domain containing protein 0.0034 0.0057 0.015
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0033 0.0029
Entamoeba histolytica cysteine protease, putative 0.0184 0.062 0.5266
Entamoeba histolytica cysteine protease, putative 0.0184 0.062 0.5266
Brugia malayi jmjC domain containing protein 0.0143 0.0464 0.1317
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0069 0.037
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0064 0.017 0.0165
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0027 0.0033 0.0029
Echinococcus multilocularis calpain 7 (C02 family) 0.0044 0.0097 0.0093
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0073 0.0523
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0035 0.0064 0.006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0114 0.0624
Schistosoma mansoni hypothetical protein 0.0054 0.0131 0.0127
Echinococcus granulosus dro:myosuppressin receptor 0.0027 0.0033 0.0029
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0073 0.0589
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0033 0.0029
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0099 0.0743
Onchocerca volvulus 0.0333 0.1173 1
Schistosoma mansoni hypothetical protein 0.0041 0.0085 0.008
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Echinococcus multilocularis jumonji domain containing 1A 0.0023 0.0018 0.0014
Entamoeba histolytica cysteine protease, putative 0.0083 0.0242 0.2038
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0011 0.002
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0203 0.1509
Echinococcus granulosus hypothetical protein 0.0027 0.0033 0.0029
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0134 0.1112
Toxoplasma gondii ABC1 family protein 0.0037 0.0069 0.0443
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0083 0.0242 0.2038
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0083 0.0242 0.0238
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0087 0.0257 0.0253
Mycobacterium ulcerans transglutaminase family protein 0.0031 0.0048 0.0112
Brugia malayi cathepsin L-like precursor 0.0232 0.0796 0.2268
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0302 0.0298
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0033 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0033 0.0029
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0131 0.0127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0277 0.0964 0.096
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0181 0.0607 0.0603
Entamoeba histolytica protein kinase, putative 0.0031 0.0048 0.0377
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0065 0.0154
Mycobacterium ulcerans putative transglutaminase-like protein 0.0031 0.0048 0.0112
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0069 0.0225
Schistosoma mansoni neuropeptide receptor 0.0027 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0116 0.0365 0.2744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0056 0.0295
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.0242 0.0683
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0036 0.0065 0.0414
Brugia malayi putative neuropeptide receptor NPR1 0.0027 0.0033 0.0084
Echinococcus granulosus jumonji domain containing 1A 0.0023 0.0018 0.0014
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0033 0.0029
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0023 0.0018 0.0014
Entamoeba histolytica hypothetical protein 0.0074 0.0208 0.1743
Trichomonas vaginalis glucosylceramidase, putative 0.0469 0.1682 0.9545
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0095
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0034 0.0057 0.0053
Brugia malayi Cathepsin L-like cysteine proteinase 0.0232 0.0796 0.2268
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0333 0.1173 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.0796 0.1959
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0181 0.0607 0.4597
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0043 0.0038
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0027 0.0033 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0056 0.0295
Mycobacterium ulcerans hypothetical protein 0.0031 0.0048 0.0112
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0131 0.0127
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0036 0.0065 0.0414
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0011 0.0036
Brugia malayi Cathepsin L-like precursor 0.0333 0.1173 0.335
Trypanosoma cruzi cysteine proteinase, putative 0.0184 0.062 0.1748
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Leishmania major hypothetical protein, conserved 0.0044 0.0096 0.0699
Brugia malayi Protein kinase domain containing protein 0.0034 0.0058 0.0153
Brugia malayi AKH receptor 0.0027 0.0033 0.0084
Loa Loa (eye worm) CXXC zinc finger family protein 0.0216 0.0737 0.1814
Onchocerca volvulus 0.0054 0.0131 0.1034
Loa Loa (eye worm) hypothetical protein 0.0104 0.0321 0.0783
Echinococcus granulosus CAAX prenyl protease 2 0.0085 0.0249 0.0245
Mycobacterium tuberculosis Hypothetical protein 0.0031 0.0048 0.0157
Loa Loa (eye worm) hypothetical protein 0.003 0.0045 0.01
Echinococcus granulosus tumor protein p63 0.0679 0.2463 0.246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0065 0.0344
Echinococcus multilocularis calpain 0.0044 0.0097 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0277 0.0964 0.096
Loa Loa (eye worm) hypothetical protein 0.0152 0.0498 0.1221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0056 0.0295
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0043 0.0038
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0069 0.0065
Entamoeba histolytica cysteine protease, putative 0.0083 0.0242 0.2038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0022 0.01
Loa Loa (eye worm) hypothetical protein 0.0064 0.017 0.0409
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0027 0.0033 0.0029
Echinococcus granulosus cathepsin L cysteine protease 0.0184 0.062 0.0616
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0461 0.0457
Echinococcus multilocularis serotonin receptor 0.0027 0.0033 0.0029
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0011 0.002
Entamoeba histolytica cysteine proteinase, putative 0.0232 0.0796 0.6772
Schistosoma mansoni hypothetical protein 0.0027 0.0033 0.0029
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0353 0.1248 0.3552
Trichomonas vaginalis glucosylceramidase, putative 0.0469 0.1682 0.9545
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0027 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0069 0.037
Entamoeba histolytica calpain large subunit domain III containing protein 0.0031 0.0047 0.0368
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0203 0.1509
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.028 0.0683
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0073 0.0338
Loa Loa (eye worm) hypothetical protein 0.0333 0.1173 0.2893
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.028 0.1571
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Echinococcus granulosus conserved hypothetical protein 0.0029 0.0039 0.0035
Plasmodium falciparum serine repeat antigen 9 0.0083 0.0242 0.2038
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0101 0.0309 0.0753
Onchocerca volvulus 0.0027 0.0033 0.0192
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0043 0.0038
Plasmodium vivax serine-repeat antigen (SERA) 0.0083 0.0242 0.2038
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0099 0.0272
Schistosoma mansoni hypothetical protein 0.0041 0.0085 0.008
Schistosoma mansoni neuropeptide receptor 0.0027 0.0033 0.0029
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0011 0.0047
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0033 0.0029
Giardia lamblia Cathepsin B precursor 0.0353 0.1248 1
Trypanosoma cruzi cysteine peptidase, putative 0.0372 0.132 0.376
Loa Loa (eye worm) hypothetical protein 0.0083 0.0242 0.059
Loa Loa (eye worm) TK/ROR protein kinase 0.0044 0.0096 0.0228
Onchocerca volvulus 0.0027 0.0033 0.0192
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0302 0.0298
Echinococcus granulosus calpain 0.0044 0.0097 0.0093
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0099 0.0095
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0097 0.0247
Schistosoma mansoni hypothetical protein 0.0041 0.0085 0.008
Schistosoma mansoni protein phosphatase 2C 0.0023 0.0018 0.0014
Mycobacterium ulcerans dehydrogenase 0.0064 0.017 0.048
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0277 0.0964 0.2751
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0043 0.0261
Entamoeba histolytica hypothetical protein 0.0025 0.0026 0.019
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0353 0.1248 0.1244
Leishmania major hypothetical protein, unknown function 0.0029 0.0039 0.0264
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0027 0.0033 0.0029
Toxoplasma gondii histone lysine methyltransferase SET1 0.0413 0.1473 1
Leishmania major cysteine peptidase A (CPA) 0.0333 0.1173 0.8879
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.108 0.612
Loa Loa (eye worm) hypothetical protein 0.0481 0.1725 0.4259
Echinococcus granulosus 7TM GPCR rhodopsin 0.0027 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0232 0.0796 0.1959
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0521 0.1875 0.463
Treponema pallidum ATP-dependent RNA helicase 0.0181 0.0607 1
Echinococcus granulosus Ankyrin 0.0034 0.0057 0.0053
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0087 0.0257 0.0253
Echinococcus granulosus snurportin 1 0.1102 0.4044 0.4042
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0242 0.0238
Giardia lamblia Kinase, PLK 0.0093 0.028 0.2042
Trypanosoma cruzi ISWI complex protein 0.0023 0.0016 0.0014
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0083 0.0242 0.0238
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0372 0.132 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0027 0.0033 0.0029
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0073 0.0069
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Echinococcus multilocularis G protein coupled receptor 139 0.0027 0.0033 0.0029
Onchocerca volvulus 0.0232 0.0796 0.6753
Brugia malayi beta-lactamase family protein 0.0037 0.0069 0.0187
Echinococcus granulosus Protein patched homolog 1 0.0043 0.009 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Onchocerca volvulus 0.0333 0.1173 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0031 0.015
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.006 0.0154 0.102
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0333 0.1173 0.6649
Onchocerca volvulus 0.0027 0.0033 0.0192
Plasmodium vivax serine-repeat antigen (SERA) 0.0083 0.0242 0.2038
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0203 0.0569
Echinococcus granulosus g protein coupled receptor 0.0027 0.0033 0.0029
Echinococcus multilocularis transmembrane protease serine 3 0.0054 0.0131 0.0127
Onchocerca volvulus 0.0027 0.0033 0.0192
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0033 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0372 0.132 1
Schistosoma mansoni amine GPCR 0.0027 0.0033 0.0029
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0064 0.017 0.1415
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0122 0.0386 0.0382
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.018 0.0602 0.1479
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Brugia malayi Papain family cysteine protease containing protein 0.0184 0.062 0.1764
Echinococcus multilocularis peregrin 0.003 0.0043 0.0039
Brugia malayi SWIRM domain containing protein 0.0064 0.017 0.0474
Toxoplasma gondii cathepsin B 0.0353 0.1248 0.8468
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0242 0.0238
Brugia malayi sulfakinin receptor protein 0.0027 0.0033 0.0084
Mycobacterium ulcerans hypothetical protein 0.0054 0.0131 0.0364
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0056 0.0353
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0069 0.037
Brugia malayi Papain family cysteine protease containing protein 0.0333 0.1173 0.335
Mycobacterium tuberculosis Conserved hypothetical protein 0.0031 0.0048 0.0157
Giardia lamblia Transglutaminase/protease, putative 0.0031 0.0048 0.0133
Trypanosoma brucei telomerase reverse transcriptase 0.0085 0.0249 0.1878
Echinococcus multilocularis calpain family protein 1, d 0.0087 0.0255 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0083 0.0242 0.1355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0242 0.1355
Mycobacterium ulcerans aldehyde dehydrogenase 0.0116 0.0365 0.1073
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0353 0.1248 0.9449
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0033 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0114 0.0624
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0328 0.1155 0.1151
Onchocerca volvulus 0.0027 0.0033 0.0192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0056 0.0295
Trypanosoma cruzi UDP-galactopyranose mutase 0.0064 0.017 0.0455
Giardia lamblia Cathepsin L-like protease 0.0083 0.0242 0.1731
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0027 0.0033 0.0029
Schistosoma mansoni amine oxidase 0.0064 0.017 0.0165
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0152 0.0498 0.0494
Onchocerca volvulus 0.0027 0.0033 0.0192
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0069 0.0176
Loa Loa (eye worm) hypothetical protein 0.0232 0.0796 0.1959
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0277 0.0964 0.096
Echinococcus granulosus transient receptor potential gamma protein 0.009 0.0266 0.0262
Onchocerca volvulus 0.0027 0.0033 0.0192
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0083 0.0242 0.2038
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0469 0.1682 0.4152
Giardia lamblia Cathepsin B precursor 0.0083 0.0242 0.1731
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0333 0.1173 0.6649
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0181 0.0607 0.4108
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0033 0.0029
Schistosoma mansoni hypothetical protein 0.0031 0.0048 0.0044
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0029 0.0039 0.0298
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0069 0.0225
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0123 0.04
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0203 0.0581
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.108 0.612
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0208 0.0204
Schistosoma mansoni netrin receptor unc5 0.0034 0.0057 0.0052
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0027 0.0033 0.0084
Loa Loa (eye worm) hypothetical protein 0.0189 0.0636 0.1563
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0033 0.0029
Echinococcus granulosus cathepsin L 0.0184 0.062 0.0616
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0015
Echinococcus multilocularis cathepsin b 0.0954 0.3493 0.349
Schistosoma mansoni cathepsin S (C01 family) 0.0083 0.0242 0.0238
Onchocerca volvulus 0.0027 0.0033 0.0192
Echinococcus granulosus PHD finger protein rhinoceros 0.0027 0.0032 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0114 0.0624
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0085 0.0249 0.0684
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0097 0.0705
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.028 0.0276
Onchocerca volvulus 0.0073 0.0203 0.1651
Trypanosoma brucei ISWI complex protein 0.0023 0.0016 0.0114
Onchocerca volvulus 0.003 0.0043 0.0271
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0333 0.1173 1
Schistosoma mansoni kinase 0.0048 0.0109 0.0105
Echinococcus multilocularis tumor protein p63 0.0679 0.2463 0.246
Brugia malayi CHE-14 protein 0.0043 0.009 0.0247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0372 0.132 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0131 0.0127
Entamoeba histolytica cysteine protease, putative 0.0184 0.062 0.5266
Echinococcus multilocularis orexin receptor type 2 0.0027 0.0033 0.0029
Plasmodium falciparum serine repeat antigen 2 0.0083 0.0242 0.2038
Loa Loa (eye worm) hypothetical protein 0.0073 0.0203 0.0492
Mycobacterium ulcerans lipase LipD 0.0037 0.0069 0.0176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0033 0.0029
Giardia lamblia Telomerase catalytic subunit 0.0085 0.0249 0.1783
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0011 0.0059
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0203 0.0569
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0054 0.0131 0.0127
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0011 0.0052
Echinococcus multilocularis lysine specific demethylase 6a 0.0023 0.0018 0.0014
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0097 0.0247
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0068 0.0184 0.018
Schistosoma mansoni phd/f-box containing protein 0.0023 0.0018 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0469 0.1682 0.9545
Echinococcus granulosus lysine specific demethylase 6a 0.0023 0.0018 0.0014
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0027 0.0033 0.0029
Schistosoma mansoni Mername-AA248 (C02 family) 0.0044 0.0097 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0114 0.0624
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.0033 0.0072
Onchocerca volvulus Cathepsin L homolog 0.0333 0.1173 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0011 0.0017
Trichomonas vaginalis esterase, putative 0.0037 0.0069 0.037
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0097 0.0247
Echinococcus granulosus death domain containing protein 0.0034 0.0057 0.0052
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0069 0.0225
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.0013 0.0078
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0033 0.0029
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.028 0.0276
Trypanosoma brucei kinesin, putative 0.0031 0.0047 0.035
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0011 0.0017
Brugia malayi Papain family cysteine protease containing protein 0.0184 0.062 0.1764
Brugia malayi Thioredoxin family protein 0.0031 0.0048 0.0126
Loa Loa (eye worm) hypothetical protein 0.0085 0.0249 0.0607
Brugia malayi Trypsin family protein 0.0054 0.0131 0.0364
Schistosoma mansoni hypothetical protein 0.0774 0.2819 0.2816
Onchocerca volvulus 0.0333 0.1173 1
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0114 0.0624
Entamoeba histolytica cysteine protease, putative 0.0083 0.0242 0.2038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0184 0.062 0.3501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0022 0.01
Echinococcus multilocularis muscleblind protein 1 0.0521 0.1875 0.1871
Plasmodium falciparum serine repeat antigen 8 0.0083 0.0242 0.2038
Trichomonas vaginalis importin beta-1, putative 0.0084 0.0244 0.1363
Loa Loa (eye worm) calpain family protein 1 0.0087 0.0255 0.062
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0114 0.0624
Entamoeba histolytica cysteine protease, putative 0.0184 0.062 0.5266
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.002 0.0005 0.0033
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0011 0.0077
Toxoplasma gondii cathepsin CPC2 0.0083 0.0242 0.1622
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0027 0.0033 0.0029
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0033 0.0072
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Toxoplasma gondii RNA-directed DNA polymerase 0.0085 0.0249 0.1666
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0032 0.0189
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0023 0.0018 0.002
Brugia malayi Melatonin receptor type 1A 0.0027 0.0033 0.0084
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0123 0.039 0.0386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0056 0.0295
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0333 0.1173 0.6649
Entamoeba histolytica cysteine proteinase, putative 0.0184 0.062 0.5266
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0123 0.039 0.0386
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0044 0.0096 0.0788
Onchocerca volvulus 0.0037 0.0069 0.0501
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0906 0.3314 1
Echinococcus multilocularis transient receptor potential ion channel A 0.0087 0.0255 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0114 0.0624
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0954 0.3493 0.349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1173 0.6649
Echinococcus multilocularis cpg binding protein 0.0228 0.0783 0.0779
Echinococcus granulosus calpain 5 0.0044 0.0097 0.0093
Giardia lamblia Cathepsin B precursor 0.0353 0.1248 1
Echinococcus multilocularis serotonin receptor 0.0027 0.0033 0.0029
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0054 0.0131 0.0127
Giardia lamblia Cathepsin B precursor 0.0083 0.0242 0.1731
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.028 0.1571
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0232 0.0796 0.4503
Brugia malayi beta-lactamase family protein 0.0037 0.0069 0.0187
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0069 0.0065
Echinococcus multilocularis protein dispatched 1 0.0049 0.0113 0.0109
Onchocerca volvulus 0.0027 0.0033 0.0192
Onchocerca volvulus Cathepsin L homolog 0.0083 0.0242 0.1992
Loa Loa (eye worm) hypothetical protein 0.0101 0.0309 0.0753
Loa Loa (eye worm) hypothetical protein 0.0064 0.017 0.0409
Schistosoma mansoni cercarial elastase (S01 family) 0.0054 0.0131 0.0127
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0033 0.0029
Brugia malayi neuropeptide F receptor 0.0027 0.0033 0.0084
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.0033 0.0072
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.028 0.2098
Loa Loa (eye worm) jmjC domain-containing protein 0.0099 0.0302 0.0737
Brugia malayi N-terminal motif family protein 0.0161 0.0532 0.1512
Loa Loa (eye worm) jmjC domain-containing protein 0.0023 0.0018 0.0034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0168 0.0164
Onchocerca volvulus 0.0029 0.0039 0.0241
Echinococcus granulosus tissue type plasminogen activator 0.0044 0.0096 0.0092
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.028 0.0791
Echinococcus multilocularis importin subunit beta 1 0.0103 0.0317 0.0313
Brugia malayi Trypsin-like protease protein 5 0.0054 0.0131 0.0364
Brugia malayi hypothetical protein 0.0027 0.0033 0.0084
Brugia malayi cathepsin B-like cysteine proteinase 0.0954 0.3493 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0134 0.0373
Trypanosoma brucei cysteine peptidase C (CPC) 0.0353 0.1248 0.945
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0034 0.0057 0.0052
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0011 0.0007
Brugia malayi jmjC domain containing protein 0.0099 0.0302 0.0853
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0029 0.0039 0.0298
Brugia malayi Pre-SET motif family protein 0.003 0.0043 0.011
Brugia malayi RNA, U transporter 1 0.0294 0.1027 0.2931
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0034
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0033 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0065 0.0344
Onchocerca volvulus 0.0027 0.0033 0.0192
Brugia malayi putative neuropeptide receptor 0.0027 0.0033 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0065 0.0344
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0054 0.0131 0.0314
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0114 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0333 0.1173 0.6649
Trichomonas vaginalis rotamase, putative 0.0031 0.0047 0.0242
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.0033 0.0072
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0083 0.0242 0.2038
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0097 0.0247
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0011 0.0036
Brugia malayi calpain 5 0.0031 0.0047 0.0123
Entamoeba histolytica cysteine protease, putative 0.0083 0.0242 0.2038
Onchocerca volvulus 0.0027 0.0033 0.0192
Mycobacterium tuberculosis Long conserved protein 0.0031 0.0048 0.0157
Loa Loa (eye worm) hypothetical protein 0.0239 0.0821 0.2023
Loa Loa (eye worm) hypothetical protein 0.0027 0.0033 0.0072
Loa Loa (eye worm) hypothetical protein 0.0037 0.0069 0.0161
Plasmodium vivax JmjC domain containing protein 0.0023 0.0018 0.0117
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.0813 0.2643
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.028 0.0276
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.028 0.1571
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0372 0.132 1
Brugia malayi Cathepsin L-like precursor 0.0232 0.0796 0.2268
Loa Loa (eye worm) hypothetical protein 0.0101 0.0309 0.0753
Plasmodium vivax vivapain-2 0.0333 0.1173 1
Loa Loa (eye worm) acetyltransferase 0.0122 0.0386 0.0945
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0333 0.1173 0.6649
Loa Loa (eye worm) glutaminase 2 0.049 0.1762 0.435
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.028 0.0773
Brugia malayi Cathepsin L-like precursor 0.0333 0.1173 0.335
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0083 0.0242 0.0238
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0065 0.0484
Loa Loa (eye worm) hypothetical protein 0.0118 0.037 0.0906
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0035 0.0064 0.006
Entamoeba histolytica cysteine proteinase 2 0.0184 0.062 0.5266
Plasmodium vivax unspecified product 0.0083 0.0242 0.2038

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.7 nM Inhibitory activity against HIV Protease in peptide cleavage assay ChEMBL. 1910089
IC50 (binding) = 2.7 nM Inhibitory activity against HIV Protease in peptide cleavage assay ChEMBL. 1910089
MIC100 (functional) = 3000 nM Ability to inhibit HIV-1 infection in H9 human T-lymphoid cells ChEMBL. 1910089
MIC100 (functional) = 3000 nM Ability to inhibit HIV-1 infection in H9 human T-lymphoid cells ChEMBL. 1910089

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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