Detailed information for compound 1727628

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 552.639 | Formula: C33H33FN4O3
  • H donors: 2 H acceptors: 3 LogP: 3.71 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(CN1CCc2c3C1CNC(=O)c3ccc2)N[C@@H](C(=O)N1CCC(=CC1)c1ccc(cc1)F)Cc1ccccc1
  • InChi: 1S/C33H33FN4O3/c34-26-11-9-23(10-12-26)24-13-16-37(17-14-24)33(41)28(19-22-5-2-1-3-6-22)36-30(39)21-38-18-15-25-7-4-8-27-31(25)29(38)20-35-32(27)40/h1-13,28-29H,14-21H2,(H,35,40)(H,36,39)/t28-,29?/m1/s1
  • InChiKey: ITFKXJTWHCODGA-FICMROCWSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens poly (ADP-ribose) polymerase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 1, putative Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma mansoni poly [ADP-ribose] polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 2, putative Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus WGR domain containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma mansoni poly [ADP-ribose] polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus multilocularis poly (adp ribose) polymerase 2 Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum ko:K00774 NAD ADP-ribosyltransferase [EC2.4.2.30], putative Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 1, putative Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 2, putative Get druggable targets OG5_128423 All targets in OG5_128423
Brugia malayi WGR domain containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus multilocularis poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Neospora caninum hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma japonicum Poly [ADP-ribose] polymerase 2-A, putative Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly adp ribose polymerase 2 Get druggable targets OG5_128423 All targets in OG5_128423
Brugia malayi WGR domain containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus multilocularis poly (ADP ribose) polymerase 1 Get druggable targets OG5_128423 All targets in OG5_128423
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma congolense poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Entamoeba histolytica poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Schistosoma mansoni poly [ADP-ribose] polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma brucei poly(adp-ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Loa Loa (eye worm) poly(ADP-ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly ADP ribose polymerase 1 Get druggable targets OG5_128423 All targets in OG5_128423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128423 All targets in OG5_128423
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative Get druggable targets OG5_128423 All targets in OG5_128423
Echinococcus granulosus poly (ADP ribose) polymerase Get druggable targets OG5_128423 All targets in OG5_128423
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ring and YY1 binding protein 0.035 0.1209 0.1209
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0088 0.0258 0.0486
Loa Loa (eye worm) phosphatidylinositol 3 0.0029 0.0047 0.0133
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0033 0.0033
Plasmodium vivax histone deacetylase, putative 0.0313 0.1073 0.3053
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0009 0.0017
Schistosoma mansoni zinc finger protein 0.0018 0.0004 0.0008
Brugia malayi MH2 domain containing protein 0.0382 0.1323 0.3771
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0213 0.0607
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0076 0.0216 0.0845
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0035 0.0093
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0076 0.0216 0.0845
Onchocerca volvulus 0.035 0.1209 0.3438
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0018 0.0004 0.0012
Toxoplasma gondii RING zinc finger protein 0.0018 0.0004 0.0012
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0088 0.0258 0.1011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0009 0.0035
Loa Loa (eye worm) histone deacetylase 7A 0.066 0.2334 0.6652
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0019 0.0019
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0213 0.0607
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0082 0.0237 0.0676
Echinococcus granulosus nuclear receptor nhr 48 0.0209 0.0698 0.0698
Plasmodium vivax RING zinc finger protein, putative 0.0018 0.0004 0.0004
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0075 0.0213 0.0607
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0213 0.1248
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Echinococcus multilocularis 0.0018 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Echinococcus granulosus ring finger protein 170 0.0018 0.0004 0.0004
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0095 0.0285 0.1117
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.0827 0.0827
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Trypanosoma cruzi histone deacetylase, putative 0.066 0.2334 0.9132
Loa Loa (eye worm) hypothetical protein 0.035 0.1209 0.3447
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Brugia malayi hypothetical protein 0.0466 0.1631 0.4649
Loa Loa (eye worm) hypothetical protein 0.0424 0.1477 0.4208
Loa Loa (eye worm) beta-lactamase 0.0075 0.0213 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Trypanosoma cruzi hypothetical protein 0.0018 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0029 0.0047 0.0088
Brugia malayi brahma associated protein 60 kDa 0.0984 0.3509 1
Brugia malayi nuclear receptor RXR 0.0209 0.0698 0.199
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0234 0.0789 0.225
Echinococcus multilocularis histone deacetylase 6 0.0736 0.261 0.261
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.035 0.1209 0.3441
Brugia malayi nuclear hormone receptor family member nhr-6 0.0209 0.0698 0.199
Loa Loa (eye worm) hypothetical protein 0.035 0.1209 0.3447
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0095 0.0285 0.0814
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0444 0.1548 0.4412
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0034 0.0064
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0009 0.0009
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0018 0.0004 0.0017
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0179 0.051
Onchocerca volvulus 0.0075 0.0213 0.0595
Onchocerca volvulus 0.0209 0.0698 0.198
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0234 0.0789 0.225
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0444 0.1548 0.2911
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0019 0.0019
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Toxoplasma gondii exonuclease III APE 0.0019 0.0009 0.0025
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Echinococcus granulosus smad 0.0026 0.0034 0.0034
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.035 0.1209 0.3447
Echinococcus granulosus poly (ADP ribose) polymerase 0.0054 0.0135 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0258 0.0736
Toxoplasma gondii histone deacetylase HDAC3 0.0721 0.2556 0.7284
Mycobacterium ulcerans lipase LipD 0.0075 0.0213 1
Echinococcus granulosus dnaJ subfamily B 0.0884 0.3147 0.3147
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0195 0.0555
Echinococcus multilocularis thyroid hormone receptor alpha 0.0444 0.1548 0.1548
Echinococcus multilocularis SWI:SNF matrix associated 0.0984 0.3509 0.3509
Onchocerca volvulus 0.0984 0.3509 1
Leishmania major hypothetical protein, conserved 0.0018 0.0004 0.0006
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0213 1
Schistosoma mansoni ap endonuclease 0.0019 0.0009 0.0017
Trichomonas vaginalis histone deacetylase, putative 0.0721 0.2556 0.7284
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0009 0.0025
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.035 0.1209 0.4732
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0082 0.0237 0.0929
Leishmania major hypothetical protein, conserved 0.035 0.1209 0.4726
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0022 0.0022
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0035 0.0138
Brugia malayi photoreceptor-specific nuclear receptor 0.0444 0.1548 0.4412
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0093 0.0278 0.0523
Loa Loa (eye worm) hypothetical protein 0.0348 0.12 0.3421
Leishmania major hypothetical protein, unknown function 0.0018 0.0004 0.0006
Giardia lamblia Histone deacetylase 0.0721 0.2556 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0444 0.1548 0.4412
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0213 0.1248
Onchocerca volvulus 0.035 0.1209 0.3438
Giardia lamblia Hypothetical protein 0.0082 0.0237 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Trypanosoma brucei histone deacetylase 3 0.066 0.2334 0.9132
Brugia malayi MH2 domain containing protein 0.0026 0.0034 0.0097
Loa Loa (eye worm) hypothetical protein 0.0075 0.0213 0.0607
Trypanosoma cruzi hypothetical protein, conserved 0.035 0.1209 0.4732
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.011 0.0339 0.0637
Schistosoma mansoni ap endonuclease 0.0019 0.0009 0.0017
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0209 0.0698 0.199
Leishmania major histone deacetylase, putative 0.0721 0.2556 1
Brugia malayi beta-lactamase 0.0075 0.0213 0.0607
Schistosoma mansoni hypothetical protein 0.005 0.0121 0.0227
Leishmania major hypothetical protein, conserved 0.0076 0.0216 0.0834
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0082 0.0237 0.0676
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0165 0.0165
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Schistosoma mansoni fkbp-rapamycin associated protein 0.0017 0.000000013979 0.000000026287
Leishmania major DNA repair protein, putative 0.0023 0.0022 0.0074
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0082 0.0237 0.0237
Echinococcus multilocularis musashi 0.0027 0.0039 0.0039
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0984 0.3509 1
Echinococcus multilocularis Smad4 0.0026 0.0034 0.0034
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.0261 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0047 0.0133
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0018 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0209 0.0698 0.199
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0018 0.0004 0.0012
Loa Loa (eye worm) histone deacetylase 3 0.0721 0.2556 0.7284
Loa Loa (eye worm) hypothetical protein 0.035 0.1209 0.3447
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0029 0.0047 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0213 0.0833
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0018 0.0004 0.0017
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0018 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0234 0.0789 0.225
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0082 0.0237 0.0669
Trichomonas vaginalis histone deacetylase, putative 0.0721 0.2556 0.7284
Schistosoma mansoni mind bomb 0.0018 0.0004 0.0008
Echinococcus multilocularis histone deacetylase 7 0.066 0.2334 0.2334
Echinococcus granulosus histone deacetylase 3 0.0721 0.2556 0.2556
Loa Loa (eye worm) hypothetical protein 0.0075 0.0213 0.0607
Brugia malayi intermediate filament protein 0.0027 0.0039 0.0111
Echinococcus granulosus zinc finger protein Ran binding 0.035 0.1209 0.1209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0112 0.0319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0128 0.0366
Echinococcus multilocularis FTZ F1 alpha 0.0444 0.1548 0.1548
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0033 0.0033
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0213 0.1248
Entamoeba histolytica histone deacetylase, putative 0.0721 0.2556 1
Echinococcus multilocularis histone deacetylase 0.066 0.2334 0.2334
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0067 0.0067
Schistosoma mansoni nuclear hormone receptor 0.0209 0.0698 0.1313
Echinococcus multilocularis zinc finger protein 0.0023 0.0022 0.0022
Trichomonas vaginalis histone deacetylase, putative 0.0721 0.2556 0.7284
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0135 0.043 0.0808
Echinococcus multilocularis GPCR, family 2 0.0049 0.0116 0.0116
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0033 0.0061
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0009 0.0025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.0496 0.1414
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0984 0.3509 0.3509
Leishmania major hypothetical protein, conserved 0.0026 0.0035 0.0127
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0082 0.0237 0.0676
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0004 0.0017
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0019 0.0008 0.0008
Trichomonas vaginalis ankyrin, putative 0.0018 0.0004 0.0012
Brugia malayi Zinc finger protein 183 homolog 0.0018 0.0004 0.0012
Echinococcus granulosus Nuclear hormone receptor HR96 0.0209 0.0698 0.0698
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0095 0.0285 0.0537
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0039 0.0111
Echinococcus multilocularis smad 0.0026 0.0034 0.0034
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Schistosoma mansoni ring finger protein 151 0.0018 0.0004 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0984 0.3509 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0018 0.0004 0.0004
Leishmania major hypothetical protein, conserved 0.0018 0.0004 0.0006
Schistosoma mansoni histone deacetylase hda2 0.0313 0.1073 0.2018
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0444 0.1548 0.1548
Mycobacterium tuberculosis Conserved protein 0.0075 0.0213 0.1248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0177 0.0504
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0018 0.0004 0.0004
Schistosoma mansoni intermediate filament proteins 0.0027 0.0039 0.0073
Schistosoma mansoni nuclear hormone receptor 0.0444 0.1548 0.2911
Leishmania major histone deacetylase, putative 0.066 0.2334 0.9131
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0035 0.0101
Loa Loa (eye worm) hypothetical protein 0.0234 0.0789 0.225
Giardia lamblia Kinase, NEK 0.0018 0.0004 0.000000054789
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0444 0.1548 0.4412
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0082 0.0237 0.0676
Chlamydia trachomatis DNA topoisomerase I 0.0984 0.3509 0.5
Loa Loa (eye worm) histone methyltransferase 0.0023 0.0022 0.0062
Brugia malayi brahma associated protein 60 kDa 0.0984 0.3509 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0193 0.0551
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0444 0.1548 0.1548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.013 0.0371
Schistosoma mansoni zinc finger protein 0.0023 0.0022 0.0042
Brugia malayi histone deacetylase 11 0.0313 0.1073 0.3059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0106
Leishmania major hypothetical protein, conserved 0.0018 0.0004 0.0006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0444 0.1548 0.1548
Brugia malayi conserved hypotetical protein 0.0209 0.0698 0.199
Brugia malayi Bromodomain containing protein 0.0037 0.0076 0.0216
Toxoplasma gondii target of rapamycin (TOR), putative 0.0065 0.0177 0.0504
Loa Loa (eye worm) hypothetical protein 0.0075 0.0213 0.0607
Loa Loa (eye worm) hypothetical protein 0.0075 0.0213 0.0607
Brugia malayi MH1 domain containing protein 0.0026 0.0034 0.0097
Echinococcus granulosus cpg binding protein 0.0068 0.0185 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Schistosoma mansoni lamin 0.0027 0.0039 0.0073
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0018 0.0004 0.0017
Brugia malayi WGR domain containing protein 0.0174 0.0569 0.1622
Brugia malayi tailless protein 0.0209 0.0698 0.199
Trichomonas vaginalis ankyrin, putative 0.0018 0.0004 0.0012
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0444 0.1548 0.2911
Plasmodium vivax zinc finger protein, putative 0.0018 0.0004 0.0004
Toxoplasma gondii histone deacetylase HDAC4 0.0313 0.1073 0.3059
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0095 0.0285 0.1117
Schistosoma mansoni steroid hormone receptor ad4bp 0.0444 0.1548 0.2911
Brugia malayi RING finger protein 20 0.0018 0.0004 0.0012
Leishmania major hypothetical protein, conserved 0.0018 0.0004 0.0006
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0032 0.0125
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0481 0.1685 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0444 0.1548 0.4412
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0209 0.0698 0.0698
Leishmania major hypothetical protein, conserved 0.035 0.1209 0.4726
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0444 0.1548 0.1548
Trichomonas vaginalis histone deacetylase, putative 0.0721 0.2556 0.7284
Echinococcus granulosus GPCR family 2 0.0049 0.0116 0.0116
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0082 0.0237 0.0676
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0004 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0213 0.0607
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0209 0.0698 0.1313
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0023 0.0022 0.0086
Echinococcus multilocularis histone deacetylase 6 0.066 0.2334 0.2334
Brugia malayi hypothetical protein 0.0234 0.0789 0.225
Trypanosoma brucei ring finger containing protein 0.0018 0.0004 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0258 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Schistosoma mansoni survival motor neuron protein 0.005 0.0121 0.0227
Entamoeba histolytica hypothetical protein 0.0027 0.0037 0.0147
Trichomonas vaginalis BRCA1-associated protein, putative 0.0076 0.0216 0.0615
Onchocerca volvulus 0.0466 0.1631 0.4643
Entamoeba histolytica hypothetical protein 0.0018 0.0004 0.0017
Echinococcus granulosus poly adp ribose polymerase 2 0.0095 0.0285 0.0285
Brugia malayi hypothetical protein 0.0026 0.0035 0.0101
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.035 0.1209 0.1209
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0179 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0444 0.1548 0.4412
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.0278 0.0793
Schistosoma mansoni smad1 5 8 and 0.0026 0.0034 0.0064
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0082 0.0237 0.0676
Schistosoma mansoni peter pan-related 0.0018 0.0004 0.0008
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0444 0.1548 0.1548
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0018 0.0004 0.0012
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.0827 0.0827
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0082 0.0237 0.0676
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Echinococcus granulosus histone deacetylase 6 0.066 0.2334 0.2334
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0179 0.8332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.013 0.0371
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0004 0.0017
Trypanosoma brucei hypothetical protein, conserved 0.035 0.1209 0.4732
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0003 0.0008
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0076 0.0216 0.0615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0147 0.0418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0112 0.0318
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0213 0.0599
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.0237 0.0929
Loa Loa (eye worm) hypothetical protein 0.0209 0.0698 0.199
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0082 0.0237 0.0446
Echinococcus multilocularis geminin 0.0184 0.0607 0.0607
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Brugia malayi hypothetical protein 0.0018 0.0004 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0004 0.0017
Onchocerca volvulus 0.0027 0.0039 0.0099
Mycobacterium tuberculosis Conserved protein 0.0075 0.0213 0.1248
Loa Loa (eye worm) hypothetical protein 0.0234 0.0789 0.225
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0034 0.0034
Echinococcus granulosus neuropeptide s receptor 0.0502 0.1761 0.1761
Loa Loa (eye worm) hypothetical protein 0.0721 0.2556 0.7284
Schistosoma mansoni RAR-like nuclear receptor 0.0444 0.1548 0.2911
Brugia malayi hypothetical protein 0.0132 0.0418 0.1191
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0009 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0076 0.0216
Entamoeba histolytica SPRY domain protein 0.0018 0.0004 0.0017
Schistosoma mansoni hypothetical protein 0.0018 0.0004 0.0008
Brugia malayi Histone deacetylase family protein 0.066 0.2334 0.6652
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0234 0.0789 0.0789
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0008 0.0008
Brugia malayi ecdysteroid receptor 0.0444 0.1548 0.4412
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0444 0.1548 0.4412
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.035 0.1209 0.4732
Mycobacterium tuberculosis Conserved protein 0.0075 0.0213 0.1248
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0034 0.0097
Loa Loa (eye worm) hypothetical protein 0.0132 0.0418 0.1191
Leishmania major hypothetical protein, conserved 0.0018 0.0004 0.0006
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0984 0.3509 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Brugia malayi MH2 domain containing protein 0.0026 0.0034 0.0097
Leishmania major hypothetical protein, conserved 0.035 0.1209 0.4726
Toxoplasma gondii hypothetical protein 0.0018 0.0004 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0003 0.0003
Leishmania major DNA repair protein-like protein 0.0018 0.0004 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0209 0.0698 0.0698
Loa Loa (eye worm) hypothetical protein 0.0209 0.0698 0.199
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0075 0.0213 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0047 0.0133
Loa Loa (eye worm) hypothetical protein 0.0209 0.0698 0.199
Trichomonas vaginalis ion channel nompc, putative 0.0018 0.0004 0.0012
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Loa Loa (eye worm) hypothetical protein 0.0209 0.0698 0.199
Brugia malayi Bromodomain containing protein 0.0077 0.0219 0.0624
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0088 0.0258 0.1011
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0234 0.0789 0.0789
Toxoplasma gondii hypothetical protein 0.0018 0.0004 0.0012
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0009 0.0035
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0003 0.0008
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0444 0.1548 0.4412
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0029 0.0047 0.0182
Loa Loa (eye worm) hypothetical protein 0.0209 0.0698 0.199
Loa Loa (eye worm) hypothetical protein 0.0132 0.0419 0.1194
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0213 0.1248
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0444 0.1548 0.4412
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Onchocerca volvulus 0.0732 0.2593 0.7386
Echinococcus multilocularis histone deacetylase 6 0.066 0.2334 0.2334
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0004 0.0017
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0238 0.0448
Loa Loa (eye worm) steroid hormone receptor 0.0444 0.1548 0.4412
Brugia malayi histone deacetylase 1 (HD1) 0.0721 0.2556 0.7284
Toxoplasma gondii histone deacetylase HDAC2 0.0721 0.2556 0.7284
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0076 0.0216 0.0845
Echinococcus multilocularis cpg binding protein 0.0068 0.0185 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0177 0.0504
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.035 0.1209 0.4732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0444 0.1548 0.4412
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0004 0.0017
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.0037 0.0037
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0019 0.0007 0.002
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.035 0.1209 0.3438
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0234 0.0789 0.1484
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0082 0.0237 0.0669
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0034 0.0034
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0018 0.0004 0.0004
Schistosoma mansoni smad 0.0026 0.0034 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.035 0.1209 0.4732
Brugia malayi nuclear hormone receptor 0.0209 0.0698 0.199
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0984 0.3509 0.3509
Brugia malayi Zinc finger, C2H2 type family protein 0.0018 0.0004 0.0012
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0034 0.0097
Schistosoma mansoni lamin 0.0027 0.0039 0.0073
Brugia malayi hypothetical protein 0.0018 0.0004 0.0012
Schistosoma mansoni smad1 5 8 and 0.0026 0.0034 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0177 0.0504
Onchocerca volvulus Bile acid receptor homolog 0.0444 0.1548 0.4405
Schistosoma mansoni cpg binding protein 0.0068 0.0185 0.0347
Plasmodium vivax histone deacetylase 1, putative 0.0721 0.2556 0.7281
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0082 0.0237 0.0676
Schistosoma mansoni histone deacetylase 1 2 3 0.0313 0.1073 0.2018
Toxoplasma gondii ABC1 family protein 0.0075 0.0213 0.0607
Trypanosoma cruzi hypothetical protein 0.0018 0.0004 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0213 0.0833
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0444 0.1548 0.4405
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0082 0.0237 0.0446
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0003 0.0003
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0004 0.0017
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0072 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0112 0.0319
Schistosoma mansoni histone deacetylase 0.0721 0.2556 0.4806
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0082 0.0237 0.0929
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0209 0.0698 0.0698
Loa Loa (eye worm) hypothetical protein 0.0069 0.0191 0.0544
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0121 0.0344
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0444 0.1548 0.1548
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0213 1
Echinococcus granulosus WGR domain containing protein 0.0054 0.0135 0.0135
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0179 0.8332
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0174 0.0569 0.2227
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Echinococcus granulosus histone deacetylase 6 0.0736 0.261 0.261
Echinococcus granulosus Nuclear pore complex protein Nup153 0.035 0.1209 0.1209
Schistosoma mansoni nuclear receptor nhr-48 0.0209 0.0698 0.1313
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.013 0.0371
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0075 0.0213 0.0607
Brugia malayi steroid hormone receptor 0.0444 0.1548 0.4412
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0018 0.0004 0.0004
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0116 0.0116
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0721 0.2556 0.7284
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0116 0.0116
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Loa Loa (eye worm) hypothetical protein 0.0444 0.1548 0.4412
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0004 0.0017
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0444 0.1548 0.4412
Echinococcus multilocularis SWI:SNF matrix associated 0.0984 0.3509 0.3509
Schistosoma mansoni histone deacetylase 4 5 0.066 0.2334 0.4389
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0216 0.0608
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Trypanosoma cruzi target of rapamycin kinase 3 0.007 0.0193 0.0757
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0643 0.2271 0.6473
Loa Loa (eye worm) histone deacetylase 1 0.0721 0.2556 0.7284
Schistosoma mansoni smad1 5 8 and 0.0026 0.0034 0.0064
Leishmania major hypothetical protein, conserved 0.0018 0.0004 0.0006
Giardia lamblia Ser/Thr protein kinase 0.0018 0.0004 0.000000054789
Loa Loa (eye worm) hypothetical protein 0.0234 0.0789 0.225
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0009 0.0018
Brugia malayi hypothetical protein 0.0018 0.0004 0.0012
Echinococcus multilocularis zinc finger protein Ran binding 0.035 0.1209 0.1209
Leishmania major cytochrome p450-like protein 0.0025 0.0032 0.0114
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0035 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0004 0.0017
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0076 0.0216 0.0604
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0009 0.0035
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0116 0.033
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Schistosoma mansoni TRABID protein (C64 family) 0.035 0.1209 0.2274
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0013 0.0037
Schistosoma mansoni thyroid hormone receptor 0.0444 0.1548 0.2911
Brugia malayi CXXC zinc finger family protein 0.0062 0.0165 0.047
Brugia malayi B-box zinc finger family protein 0.0018 0.0004 0.0012
Trypanosoma brucei predicted zinc finger protein 0.0018 0.0004 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0007 0.002
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0034 0.0034
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0018 0.0004 0.0004
Plasmodium vivax trophozoite exported protein 1, putative 0.0018 0.0004 0.0004
Schistosoma mansoni histone deacetylase 4 5 0.066 0.2334 0.4389
Loa Loa (eye worm) hypothetical protein 0.0075 0.0213 0.0607
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0076 0.0216 0.0615
Loa Loa (eye worm) hypothetical protein 0.011 0.0339 0.0966
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0018 0.0004 0.0012
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0018 0.0004 0.0012
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0042 0.009 0.0354
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0444 0.1548 0.1548
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0209 0.0698 0.0698
Toxoplasma gondii helicase, putative 0.0018 0.0004 0.0012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0088 0.0258 0.0736
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0101
Schistosoma mansoni hypothetical protein 0.0984 0.3509 0.6598
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0082 0.0237 0.0237
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0004 0.0017
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.0018 0.0004 0.0004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0444 0.1548 0.2911
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Plasmodium vivax histone deacetylase, putative 0.066 0.2334 0.6649
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0023 0.0022 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0444 0.1548 0.4412
Schistosoma mansoni voltage-gated potassium channel 0.0082 0.0238 0.0448
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0018 0.0004 0.0012
Echinococcus granulosus Smad4 0.0026 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.035 0.1209 0.2274
Schistosoma mansoni hypothetical protein 0.002 0.0013 0.0024
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0209 0.0698 0.1313
Brugia malayi Pre-SET motif family protein 0.0643 0.2271 0.6473
Loa Loa (eye worm) transcription factor SMAD2 0.0382 0.1323 0.3771
Loa Loa (eye worm) hypothetical protein 0.0209 0.0698 0.199
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0032 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Schistosoma mansoni nuclear hormone receptor 0.0209 0.0698 0.1313
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Brugia malayi YY1-associated factor 2 0.035 0.1209 0.3447
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.0018 0.0004 0.0004
Echinococcus multilocularis microtubule associated protein 2 0.1483 0.5318 0.5318
Leishmania major hypothetical protein, conserved 0.0018 0.0004 0.0006
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.0023 0.0022 0.0074
Loa Loa (eye worm) hypothetical protein 0.0406 0.1412 0.4025
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.035 0.1209 0.3447
Plasmodium falciparum trophozoite exported protein 1 0.0018 0.0004 0.0004
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0213 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0193 0.0551
Brugia malayi nuclear receptor NHR-88 0.0209 0.0698 0.199
Trypanosoma brucei histone deacetylase 2 0.0313 0.1073 0.4199
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0004 0.0017
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0082 0.0237 0.0676
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0076 0.0216 0.0845
Brugia malayi hypothetical protein 0.0017 0.0001 0.0004
Giardia lamblia GTOR 0.0088 0.0258 0.0996
Echinococcus multilocularis lamin 0.0027 0.0039 0.0039
Echinococcus multilocularis histone deacetylase 1 0.0721 0.2556 0.2556
Plasmodium vivax histone deacetylase 2, putative 0.066 0.2334 0.6649
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0003 0.0003
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.0237 0.0929
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Schistosoma mansoni hypothetical protein 0.0018 0.0004 0.0008
Plasmodium vivax DNA repair protein RAD5, putative 0.0018 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0444 0.1548 0.4412
Schistosoma mansoni coup transcription factor 0.0444 0.1548 0.2911
Echinococcus multilocularis ring finger protein 113a 0.0018 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0177 0.0504
Echinococcus granulosus FTZ F1 alpha 0.0444 0.1548 0.1548
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0444 0.1548 0.1548
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0003 0.0011
Onchocerca volvulus 0.0062 0.0165 0.0458
Trypanosoma brucei histone deacetylase, putative 0.066 0.2334 0.9132
Echinococcus granulosus ring and YY1 binding protein 0.035 0.1209 0.1209
Echinococcus multilocularis Zinc finger, RanBP2 type 0.035 0.1209 0.1209
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0116 0.0116
Echinococcus multilocularis SWI:SNF matrix associated 0.0984 0.3509 0.3509
Trichomonas vaginalis set domain proteins, putative 0.0732 0.2593 0.7389
Brugia malayi hypothetical protein 0.0018 0.0004 0.0012
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0213 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0193 0.0551
Onchocerca volvulus DNA ligase 3 homolog 0.0023 0.0022 0.005
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.0237 0.0929
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0009 0.0025
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.0037 0.0037
Entamoeba histolytica hypothetical protein 0.0073 0.0205 0.0803
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.035 0.1209 0.3447
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0076 0.0216 0.0845
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0112 0.0318
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0004 0.0017
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0082 0.0237 0.0676
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0213 0.0607
Echinococcus granulosus histone lysine methyltransferase setb 0.011 0.0339 0.0339
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0082 0.0239 0.0449
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0018 0.0004 0.0004
Onchocerca volvulus 0.0075 0.0213 0.0595
Leishmania major hypothetical protein, conserved 0.035 0.1209 0.4726
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0018 0.0004 0.0017
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0035 0.0138
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.035 0.1209 0.3447
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0444 0.1548 0.4412
Loa Loa (eye worm) hypothetical protein 0.0444 0.1548 0.4412
Plasmodium falciparum E3 ubiquitin-protein ligase RNF5, putative 0.0018 0.0004 0.0004
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0018 0.0004 0.0012
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0116 0.033
Loa Loa (eye worm) hypothetical protein 0.0209 0.0698 0.199
Loa Loa (eye worm) hypothetical protein 0.0234 0.0789 0.225
Loa Loa (eye worm) nuclear receptor NHR-67 0.0209 0.0698 0.199
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Echinococcus granulosus histone deacetylase 6 0.066 0.2334 0.2334
Brugia malayi Histone deacetylase family protein 0.066 0.2334 0.6652
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0209 0.0698 0.199
Schistosoma mansoni retinoic acid receptor RXR 0.0444 0.1548 0.2911
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0984 0.3509 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0047 0.0133
Leishmania major hypothetical protein, conserved 0.0018 0.0004 0.0006
Entamoeba histolytica hypothetical protein 0.0073 0.0205 0.0803
Echinococcus granulosus thyroid hormone receptor alpha 0.0209 0.0698 0.0698
Brugia malayi hypothetical protein 0.0209 0.0698 0.199
Brugia malayi Nuclear hormone receptor-like 1 0.0234 0.0789 0.225
Echinococcus multilocularis histone deacetylase 8 0.0313 0.1073 0.1073
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0018 0.0004 0.0008
Entamoeba histolytica hypothetical protein 0.0073 0.0205 0.0803
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0082 0.0237 0.0237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0177 0.0504
Schistosoma mansoni peter pan-related 0.0018 0.0004 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0193 0.0551
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.035 0.1209 0.4732
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0034 0.0034
Echinococcus granulosus histone deacetylase 1 0.0721 0.2556 0.2556
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0721 0.2556 0.7284
Mycobacterium ulcerans beta-lactamase 0.0075 0.0213 1
Trypanosoma cruzi histone deacetylase, putative 0.0313 0.1073 0.4199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0047 0.0133
Loa Loa (eye worm) hypothetical protein 0.0209 0.0698 0.199
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.0018 0.0004 0.0012
Entamoeba histolytica hypothetical protein 0.0018 0.0004 0.0017
Echinococcus granulosus SWI:SNF matrix associated 0.0984 0.3509 0.3509
Brugia malayi hypothetical protein 0.0245 0.0827 0.2358
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0049 0.0116 0.0218
Loa Loa (eye worm) Smad1 0.0026 0.0034 0.0097
Loa Loa (eye worm) hypothetical protein 0.0153 0.0496 0.1414
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0721 0.2556 0.7284
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0018 0.0004 0.0012
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0019 0.0019
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0082 0.0237 0.0237
Trypanosoma cruzi histone deacetylase 1, putative 0.0721 0.2556 1
Onchocerca volvulus 0.035 0.1209 0.3438
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0213 0.0607
Echinococcus granulosus lamin 0.0027 0.0039 0.0039
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0029 0.0047 0.0182
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0088 0.0258 0.1011
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0032 0.1135
Echinococcus granulosus ring finger protein 113a 0.0018 0.0004 0.0004
Plasmodium falciparum zinc finger protein, putative 0.0018 0.0004 0.0004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.0047 0.0133
Schistosoma mansoni nuclear receptor 0.0209 0.0698 0.1313
Brugia malayi hypothetical protein 0.0209 0.0698 0.199
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0029 0.0047 0.0047
Trichomonas vaginalis hypothetical protein 0.0018 0.0004 0.0012
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0082 0.0237 0.0669
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0205 0.0386
Leishmania major hypothetical protein, conserved 0.0018 0.0004 0.0006
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0177 0.0504
Brugia malayi SWIB/MDM2 domain containing protein 0.0984 0.3509 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0112 0.0318
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0216 0.0608
Brugia malayi WGR domain containing protein 0.0095 0.0285 0.0814
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0112 0.0319
Onchocerca volvulus 0.0444 0.1548 0.4405
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0881 0.3133 0.3133
Schistosoma mansoni thyroid hormone receptor 0.0444 0.1548 0.2911
Loa Loa (eye worm) DR-78 0.0209 0.0698 0.199
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0009 0.0025
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0213 0.1248
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0444 0.1548 0.4412
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0002 0.0007
Brugia malayi Nuclear hormone receptor E75 0.0209 0.0698 0.199
Toxoplasma gondii histone deacetylase HDAC1 0.066 0.2334 0.6652
Loa Loa (eye worm) hypothetical protein 0.0209 0.0698 0.199
Schistosoma mansoni rnf5 0.0018 0.0004 0.0008
Onchocerca volvulus 0.0027 0.0039 0.0099
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0184 0.0607 0.1141
Onchocerca volvulus 0.0075 0.0213 0.0595
Leishmania major hypothetical protein, conserved 0.0018 0.0004 0.0006
Echinococcus granulosus intermediate filament protein 0.0027 0.0039 0.0039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0123 0.0387 0.1103
Brugia malayi Cytochrome P450 family protein 0.0025 0.0032 0.0091
Loa Loa (eye worm) hypothetical protein 0.0313 0.1073 0.3059
Echinococcus granulosus neuropeptide receptor A26 0.0502 0.1761 0.1761
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0082 0.0237 0.0676
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Brugia malayi BRCA1-associated protein 2 containing protein 0.0076 0.0216 0.0615
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0039 0.0111
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0009 0.0036
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0076 0.0216 0.0845
Loa Loa (eye worm) hypothetical protein 0.0105 0.032 0.0912
Brugia malayi hypothetical protein 0.0234 0.0789 0.225
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0004 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0444 0.1548 0.4412
Schistosoma mansoni brca1-associated protein (brap2) 0.0076 0.0216 0.0406
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0444 0.1548 0.1548
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0213 0.04
Mycobacterium ulcerans hypothetical protein 0.0075 0.0213 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0088 0.0258 0.1011
Echinococcus granulosus poly ADP ribose polymerase 1 0.0174 0.0569 0.0569
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0019 0.0035
Echinococcus granulosus histone deacetylase 0.066 0.2334 0.2334
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.0496 0.1414
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0179 0.0336
Trichomonas vaginalis ankyrin, putative 0.0018 0.0004 0.0012
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0039 0.0111
Onchocerca volvulus 0.0093 0.0278 0.0782
Loa Loa (eye worm) hypothetical protein 0.004 0.0084 0.024
Echinococcus multilocularis neuropeptide s receptor 0.0502 0.1761 0.1761
Brugia malayi Neuralized family protein 0.0018 0.0004 0.0012
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0035 0.0093
Plasmodium vivax hypothetical protein, conserved 0.0984 0.3509 1
Echinococcus multilocularis lamin dm0 0.0027 0.0039 0.0039
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.035 0.1209 0.4732
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0095 0.0285 0.0285
Onchocerca volvulus Histone deacetylase 10 homolog 0.0313 0.1073 0.305
Echinococcus granulosus poly (ADP ribose) polymerase 0.0027 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0082 0.0237 0.0676
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0209 0.0698 0.0698
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0112 0.0319
Brugia malayi nuclear hormone receptor family member odr-7 0.0209 0.0698 0.199
Schistosoma mansoni hypothetical protein 0.0184 0.0607 0.1141
Echinococcus granulosus geminin 0.0184 0.0607 0.0607
Echinococcus multilocularis RING finger protein 185 0.0018 0.0004 0.0004
Echinococcus multilocularis histone deacetylase 3 0.0721 0.2556 0.2556
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0029 0.0047 0.0171
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0082 0.0237 0.0676
Leishmania major hypothetical protein, conserved 0.0018 0.0004 0.0006
Brugia malayi hypothetical protein 0.0018 0.0004 0.0012
Onchocerca volvulus Huntingtin homolog 0.0132 0.0418 0.118
Onchocerca volvulus Protein ultraspiracle homolog 0.0444 0.1548 0.4405
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0082 0.0237 0.0676
Loa Loa (eye worm) hypothetical protein 0.0209 0.0698 0.199
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.032 0.0912
Leishmania major hypothetical protein, conserved 0.0075 0.0213 0.0822
Brugia malayi beta-lactamase family protein 0.0075 0.0213 0.0607
Loa Loa (eye worm) histone deacetylase 11 0.0313 0.1073 0.3059
Loa Loa (eye worm) histone deacetylase 0.066 0.2334 0.6652
Loa Loa (eye worm) RING finger protein 20 0.0018 0.0004 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0004 0.0017
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0082 0.0237 0.0913
Brugia malayi MH1 domain containing protein 0.0026 0.0034 0.0097
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0018 0.0004 0.0012
Echinococcus granulosus histone deacetylase 8 0.0313 0.1073 0.1073
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0009 0.0024
Schistosoma mansoni nuclear receptor 0.0209 0.0698 0.1313
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0018 0.0004 0.0012
Onchocerca volvulus 0.0209 0.0698 0.198
Trypanosoma brucei hypothetical protein, conserved 0.035 0.1209 0.4732
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0213 0.0607
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0009 0.0017
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0209 0.0698 0.0698
Schistosoma mansoni cpg binding protein 0.0062 0.0165 0.031
Echinococcus multilocularis nuclear receptor nhr 48 0.0209 0.0698 0.0698
Echinococcus granulosus lamin dm0 0.0027 0.0039 0.0039
Schistosoma mansoni cellular tumor antigen P53 0.0406 0.1412 0.2656
Echinococcus granulosus RING finger protein 185 0.0018 0.0004 0.0004
Plasmodium falciparum histone deacetylase 1 0.0721 0.2556 0.7281
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0444 0.1548 0.4412
Echinococcus multilocularis dnaJ subfamily B 0.0884 0.3147 0.3147
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0174 0.0569 0.107
Schistosoma mansoni RNA binding protein 0.035 0.1209 0.2274
Loa Loa (eye worm) hypothetical protein 0.0045 0.0104 0.0296
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0179 0.8332
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.007 0.0195 0.0555
Trypanosoma cruzi WLM domain containing protein, putative 0.035 0.1209 0.4732
Plasmodium falciparum histone deacetylase, putative 0.066 0.2334 0.6649
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0444 0.1548 0.2911
Trypanosoma cruzi histone deacetylase, putative 0.066 0.2334 0.9132
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0018 0.0004 0.0004
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.018 0.0594 0.1692
Brugia malayi Pre-SET motif family protein 0.0093 0.0278 0.0793
Schistosoma mansoni hypothetical protein 0.0049 0.0116 0.0218
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Leishmania major hypothetical protein, conserved 0.0018 0.0004 0.0006
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0018 0.0004 0.0012
Echinococcus granulosus histone deacetylase 7 0.066 0.2334 0.2334
Toxoplasma gondii hypothetical protein 0.0018 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.0496 0.1414
Entamoeba histolytica hypothetical protein 0.0073 0.0205 0.0803
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0213 0.1248
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0029 0.0047 0.0182
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0009 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0444 0.1548 0.2911
Trypanosoma brucei target of rapamycin kinase 3, putative 0.007 0.0193 0.0757
Trypanosoma cruzi histone deacetylase 1, putative 0.0721 0.2556 1
Loa Loa (eye worm) RiNg Finger protein family member 0.0018 0.0004 0.0012
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0003 0.0005
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0003 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0177 0.0504
Echinococcus granulosus BRCA1 associated protein 0.0076 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0025 0.0072
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0088 0.0258 0.1011
Schistosoma mansoni hypothetical protein 0.0073 0.0205 0.0386
Loa Loa (eye worm) brahma associated protein 0.0984 0.3509 1
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0018 0.0004 0.0012
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Plasmodium vivax SET domain protein, putative 0.0093 0.0278 0.0786
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0008 0.0008
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0032 0.0125
Onchocerca volvulus 0.035 0.1209 0.3438
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0444 0.1548 0.4412
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0116 0.033
Plasmodium falciparum histone deacetylase 2 0.066 0.2334 0.6649
Schistosoma mansoni histone deacetylase hda2 0.0736 0.261 0.4908
Echinococcus multilocularis ring finger protein 170 0.0018 0.0004 0.0004
Schistosoma mansoni histone deacetylase 0.0721 0.2556 0.4806
Loa Loa (eye worm) hypothetical protein 0.0049 0.0116 0.033
Onchocerca volvulus 0.005 0.0121 0.0332
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0213 0.1248
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0212 0.0604
Brugia malayi Cytochrome P450 family protein 0.0025 0.0032 0.0091
Chlamydia trachomatis SWIB complex protein 0.0984 0.3509 0.5
Brugia malayi nuclear hormone receptor 0.0444 0.1548 0.4412
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0209 0.0698 0.199
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0022 0.0022
Onchocerca volvulus Huntingtin homolog 0.0132 0.0418 0.118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0153 0.0437
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0032 0.0091
Loa Loa (eye worm) hypothetical protein 0.0444 0.1548 0.4412
Loa Loa (eye worm) hypothetical protein 0.0132 0.0418 0.1191
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0165 0.047
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0209 0.0698 0.198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0047 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0193 0.0551
Schistosoma mansoni fusion 0.035 0.1209 0.2274
Loa Loa (eye worm) hypothetical protein 0.0245 0.0827 0.2358
Trypanosoma brucei histone deacetylase 4 0.066 0.2334 0.9132
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0444 0.1548 0.1548
Plasmodium falciparum E3 ubiquitin-protein ligase, putative 0.0018 0.0004 0.0004
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0068 0.0188 0.0535
Schistosoma mansoni microtubule-associated protein tau 0.1483 0.5318 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.035 0.1209 0.4732
Loa Loa (eye worm) hypothetical protein 0.0444 0.1548 0.4412
Brugia malayi hypothetical protein 0.0018 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0444 0.1548 0.4412
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0018 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0444 0.1548 0.4412
Echinococcus multilocularis BRCA1 associated protein 0.0076 0.0216 0.0216
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Brugia malayi Histone deacetylase 1 0.0721 0.2556 0.7284
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0035 0.0138
Echinococcus multilocularis ecdysone induced protein 78C 0.0444 0.1548 0.1548
Brugia malayi orphan nuclear receptor NR2E1 0.0209 0.0698 0.199
Schistosoma mansoni zinc finger protein 0.035 0.1209 0.2274
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0209 0.0698 0.198
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0003 0.0011
Trichomonas vaginalis brca1-associated protein, putative 0.0076 0.0216 0.0615
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0075 0.0213 0.0213
Echinococcus granulosus Nuclear hormone receptor HR96 0.0209 0.0698 0.0698
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0019 0.0035
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0082 0.0237 0.0446
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0213 0.0213
Trypanosoma cruzi histone deacetylase, putative 0.066 0.2334 0.9132
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0075 0.0213 0.0607
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0028 0.0079
Echinococcus multilocularis neuropeptide receptor A26 0.0502 0.1761 0.1761
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0209 0.0698 0.199
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0088 0.0258 0.1011
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0205 0.0205
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0174 0.0569 0.0569
Trypanosoma cruzi WLM domain containing protein, putative 0.035 0.1209 0.4732
Brugia malayi ecdysone receptor 0.0209 0.0698 0.199
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.007 0.0193 0.0746
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0213 0.04
Onchocerca volvulus 0.0406 0.1412 0.4017
Schistosoma mansoni brg-1 associated factor 0.0984 0.3509 0.6598
Toxoplasma gondii hypothetical protein 0.0018 0.0004 0.0012
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0179 0.0689
Schistosoma mansoni bromodomain containing protein 0.0065 0.0177 0.0333
Trypanosoma brucei DNA repair protein, putative 0.0018 0.0004 0.0017
Brugia malayi Smad1 0.0026 0.0034 0.0097
Echinococcus granulosus microtubule associated protein 2 0.1483 0.5318 0.5318
Trichomonas vaginalis histone deacetylase, putative 0.0721 0.2556 0.7284
Trypanosoma brucei DNA repair protein, putative 0.0023 0.0022 0.0086
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0019 0.0019
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0165 0.0165
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Schistosoma mansoni brca1-associated protein (brap2) 0.0076 0.0216 0.0406
Loa Loa (eye worm) hypothetical protein 0.0444 0.1548 0.4412
Leishmania major hypothetical protein, conserved 0.0018 0.0004 0.0006
Brugia malayi Nuclear hormone receptor E75 0.0209 0.0698 0.199
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Brugia malayi beta-lactamase family protein 0.0075 0.0213 0.0607
Echinococcus granulosus zinc finger protein 0.0023 0.0022 0.0022
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0088 0.0258 0.1001
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0032 0.0091
Loa Loa (eye worm) MH2 domain-containing protein 0.0382 0.1323 0.3771
Schistosoma mansoni hypothetical protein 0.0049 0.0116 0.0218
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.035 0.1209 0.4732
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0009 0.0035
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0209 0.0698 0.0698
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0082 0.0237 0.0669
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0082 0.0237 0.0918
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.011 0.0339 0.0339
Brugia malayi RING zinc finger protein 0.0018 0.0004 0.0012
Echinococcus granulosus Zinc finger RanBP2 type 0.035 0.1209 0.1209
Loa Loa (eye worm) hypothetical protein 0.0466 0.1631 0.4649
Echinococcus multilocularis poly (ADP ribose) polymerase 0.004 0.0084 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.035 0.1209 0.4732
Trypanosoma cruzi histone deacetylase, putative 0.0313 0.1073 0.4199
Brugia malayi Nuclear hormone receptor-like 1 0.0444 0.1548 0.4412
Schistosoma mansoni hypothetical protein 0.0884 0.3147 0.5918
Echinococcus granulosus ecdysone induced protein 78C 0.0444 0.1548 0.1548
Loa Loa (eye worm) hypothetical protein 0.035 0.1209 0.3447
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0008 0.0015
Trypanosoma cruzi DNA repair protein, putative 0.0023 0.0022 0.0086
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0213 0.0607
Brugia malayi isocitrate dehydrogenase 0.0017 0.0003 0.0008
Plasmodium falciparum RING zinc finger protein, putative 0.0018 0.0004 0.0004
Leishmania major histone deacetylase, putative 0.0721 0.2556 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0082 0.0237 0.0237
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0018 0.0004 0.0004
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0128 0.0366
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.011 0.0339 0.0637
Toxoplasma gondii histone deacetylase HDAC5 0.0313 0.1073 0.3059
Loa Loa (eye worm) phosphatidylinositol 3 0.0088 0.0258 0.0736
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0444 0.1548 0.2911
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0444 0.1548 0.1548
Schistosoma mansoni hypothetical protein 0.0105 0.032 0.0602
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Brugia malayi nuclear receptor RXR 0.0234 0.0789 0.225
Leishmania major phosphatidylinositol 3-kinase, putative 0.0029 0.0047 0.0171
Schistosoma mansoni hypothetical protein 0.0018 0.0004 0.0008
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0019 0.0054
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Brugia malayi histone deacetylase 3 (HD3) 0.0721 0.2556 0.7284
Schistosoma mansoni hypothetical protein 0.0049 0.0116 0.0218
Brugia malayi nuclear receptor NHR-88 0.0444 0.1548 0.4412
Echinococcus granulosus mixed lineage leukemia protein mll 0.0019 0.0008 0.0008
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0088 0.0258 0.0258
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0032 0.0091
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0213 0.0833
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0444 0.1548 0.1548
Trichomonas vaginalis esterase, putative 0.0075 0.0213 0.0607
Trypanosoma brucei histone deacetylase 1 0.0721 0.2556 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0444 0.1548 0.4412
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0234 0.0789 0.1484
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0278 0.0523
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0444 0.1548 0.4412
Loa Loa (eye worm) hypothetical protein 0.0444 0.1548 0.4412
Brugia malayi nuclear receptor NHR-67 0.0209 0.0698 0.199
Loa Loa (eye worm) nuclear hormone receptor 0.0209 0.0698 0.199
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Schistosoma mansoni cpg binding protein 0.0068 0.0185 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0984 0.3509 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0984 0.3509 1
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0018 0.0004 0.0012
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0088 0.0258 0.0258
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0067 0.0067
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0003 0.0008
Giardia lamblia Protein 21.1 0.0018 0.0004 0.000000054789
Schistosoma mansoni zinc finger protein 0.0209 0.0698 0.1313
Toxoplasma gondii ran binding protein 0.035 0.1209 0.3447
Echinococcus granulosus cell growth regulator with ring finger domain 0.0018 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.035 0.1209 0.3447
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.035 0.1209 0.3447
Trypanosoma brucei poly(adp-ribose) polymerase 0.0095 0.0285 0.1117
Brugia malayi PHD-finger family protein 0.0028 0.0041 0.0117
Schistosoma mansoni Smad4 0.0026 0.0034 0.0064
Mycobacterium leprae Probable lipase LipE 0.0075 0.0213 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0062
Brugia malayi Steroid receptor seven-up type 2 0.0444 0.1548 0.4412
Leishmania major hypothetical protein, conserved 0.0076 0.0216 0.0834
Brugia malayi hypothetical protein 0.0073 0.0205 0.0585
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0003 0.0011
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Schistosoma mansoni hypothetical protein 0.0984 0.3509 0.6598
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0205 0.0205
Leishmania major histone deacetylase, putative 0.066 0.2334 0.9131
Trichomonas vaginalis histone deacetylase, putative 0.0721 0.2556 0.7284
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0444 0.1548 0.1548
Leishmania major hypothetical protein, conserved 0.035 0.1209 0.4726
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0004 0.0012
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0029 0.0047 0.0182
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0018 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0004 0.0017
Schistosoma mansoni hypothetical protein 0.0984 0.3509 0.6598
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0018 0.0004 0.0004
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0984 0.3509 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0444 0.1548 0.4412
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0179 0.1046
Entamoeba histolytica zinc finger domain containing protein 0.0018 0.0004 0.0017
Leishmania major hypothetical protein 0.0018 0.0004 0.0006
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0088 0.0258 0.1001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0258 0.0736

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibition of human recombinant PARP1 after 1 hr by ELISA ChEMBL. 23473053

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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