Detailed information for compound 1766909

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 537.755 | Formula: C28H47N3O5S
  • H donors: 3 H acceptors: 3 LogP: 5.51 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: [O-]S(=O)(=O)O/C=C/1\CCC2[C@@]([C@@H]1CCc1cocc1)(C)CCC1[C@]2(C)CCCC1(C)C.NC(=[N+](C)C)N
  • InChi: 1S/C25H38O5S.C3H9N3/c1-23(2)12-5-13-25(4)21(23)10-14-24(3)20(8-6-18-11-15-29-16-18)19(7-9-22(24)25)17-30-31(26,27)28;1-6(2)3(4)5/h11,15-17,20-22H,5-10,12-14H2,1-4H3,(H,26,27,28);1-2H3,(H3,4,5)/b19-17+;/t20-,21?,22?,24+,25+;/m1./s1
  • InChiKey: MUGYGAQKMRBEQJ-OTPFPBRVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nervana 2 0.0231 0.0678 0.5666
Mycobacterium ulcerans beta-lactamase 0.0035 0.0071 0.0034
Echinococcus granulosus dnaJ subfamily B 0.0398 0.1196 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0029 0.059
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0022 0.0029 0.033
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0454 0.3794
Brugia malayi MBOAT family protein 0.0022 0.0029 0.0414
Echinococcus granulosus sentrin specific protease 8 0.0065 0.0164 0.1368
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0022 0.0029 0.0246
Plasmodium falciparum plasmepsin III 0.0071 0.0182 0.3816
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0032
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0071 0.0035
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0003 0.0032
Echinococcus granulosus snurportin 1 0.03 0.0893 0.747
Onchocerca volvulus 0.0028 0.0049 0.0576
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0071 0.1005
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0018 0.0249
Brugia malayi aspartic protease BmAsp-1, identical 0.0071 0.0182 0.2565
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0166 0.0476 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0032
Schistosoma mansoni phosphoglycerate kinase 0.0166 0.0476 0.0872
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0039 0.0781
Brugia malayi jmjC domain containing protein 0.0025 0.0039 0.0542
Brugia malayi mbt repeat family protein 0.0046 0.0106 0.1494
Schistosoma mansoni ATPase 0.0049 0.0115 0.0208
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0054 0.013 0.2711
Loa Loa (eye worm) hypothetical protein 0.0166 0.0476 0.5325
Onchocerca volvulus Huntingtin homolog 0.0125 0.035 0.4226
Loa Loa (eye worm) hypothetical protein 0.0053 0.0126 0.1412
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0033 0.0667
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0039 0.0781
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0065 0.0164 0.3418
Plasmodium falciparum importin beta, putative 0.0028 0.005 0.1015
Onchocerca volvulus 0.0035 0.0071 0.0842
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0029 0.033
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.033
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0049 0.0115 0.2384
Schistosoma mansoni hypothetical protein 0.0029 0.0051 0.0091
Leishmania major P-type H -ATPase, putative 0.0027 0.0045 0.0926
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0065 0.0164 0.3418
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0279 0.0827 0.1518
Plasmodium vivax aspartyl proteinase, putative 0.0071 0.0182 0.3816
Plasmodium falciparum protein arginine N-methyltransferase 5, putative 0.0061 0.0152 0.3175
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0039 0.0068
Onchocerca volvulus 0.0035 0.0071 0.0842
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0054 0.013 0.1088
Trypanosoma cruzi GUP1, putative 0.0022 0.0029 0.059
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0039 0.0068
Leishmania major P-type ATPase, putative 0.0054 0.013 0.2711
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0071 0.0035
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0041 0.0829
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0146 0.3038
Echinococcus multilocularis sentrin specific protease 8 0.0065 0.0164 0.0164
Brugia malayi aspartic protease BmAsp-2, identical 0.0071 0.0182 0.2565
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0071 0.0182 0.0333
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0323 0.3621
Brugia malayi Phosphoglycerate kinase 0.0061 0.0151 0.2121
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0071 0.1466
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0106 0.0193
Entamoeba histolytica phosphoglycerate kinase, putative 0.0166 0.0476 1
Plasmodium vivax aspartyl protease, putative 0.0071 0.0182 0.3816
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0039 0.0431
Trypanosoma brucei phosphoglycerate kinase 0.0166 0.0476 1
Plasmodium vivax aspartyl protease, putative 0.0071 0.0182 0.3816
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0055 0.0134 0.2798
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0137 0.0388 0.0654
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0146 0.018
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0027 0.0027
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0245 0.3448
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0627 0.1907 0.375
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.033
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0054 0.013 0.0236
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0529
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0431
Plasmodium vivax JmjC domain containing protein 0.0025 0.0039 0.0781
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0029 0.0029
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0002 0.0021
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0071 0.1475
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0126 0.0229
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0106 0.1269
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0022 0.0029 0.059
Echinococcus multilocularis calcium transporting atpase 0.0054 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0034
Echinococcus multilocularis snurportin 1 0.03 0.0893 0.0893
Loa Loa (eye worm) Ulp1 protease 0.0013 0.0002 0.0017
Brugia malayi hypothetical protein 0.0016 0.0013 0.0183
Leishmania major glycerol uptake protein, putative 0.0022 0.0029 0.059
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0049 0.0549
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0054 0.013 0.015
Echinococcus multilocularis nervana 2 0.0231 0.0678 0.0678
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0055 0.0134 0.2798
Schistosoma mansoni importin beta-1 0.0028 0.005 0.0088
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0055 0.0134 0.1887
Trypanosoma cruzi GUP1, putative 0.0022 0.0029 0.059
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0055 0.0134 0.2798
Trichomonas vaginalis esterase, putative 0.0035 0.0071 0.1466
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0231 0.0678 0.0678
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0039 0.0039
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0054 0.013 0.2711
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0071 0.1475
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0151 0.043 0.043
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0049 0.0115 0.2384
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0054 0.013 0.013
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0071 0.08
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0142 0.0403 0.8478
Chlamydia trachomatis phosphoglycerate kinase 0.0166 0.0476 1
Toxoplasma gondii aspartyl protease 0.0071 0.0182 0.3816
Leishmania major glycerol uptake protein, putative 0.0022 0.0029 0.059
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0022 0.0029 0.0029
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0055 0.0134 0.0158
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0055 0.0134 0.2798
Schistosoma mansoni transmemberane protein 0.0279 0.0827 0.1518
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0055 0.0134 0.0244
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0051 0.0051
Schistosoma mansoni ran 0.0021 0.0027 0.0046
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0151 0.3149
Loa Loa (eye worm) aspartyl protease 6 0.0071 0.0182 0.2043
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.0151 0.3149
Leishmania major calcium-translocating P-type ATPase 0.0049 0.0115 0.2384
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0106 0.0106
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0054 0.013 0.1088
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.0253 0.0462
Trypanosoma cruzi arginine N-methyltransferase, type II, putative 0.0039 0.0084 0.1738
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0156 0.0156
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0029 0.0246
Mycobacterium ulcerans lipase LipD 0.0035 0.0071 0.0034
Schistosoma mansoni survival motor neuron protein 0.0049 0.0115 0.0209
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0054 0.013 0.1088
Brugia malayi diacylglycerol acyltransferase 0.0022 0.0029 0.0414
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0041 0.0829
Loa Loa (eye worm) hypothetical protein 0.0142 0.0403 0.4517
Brugia malayi hypothetical protein 0.0242 0.0711 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0026 0.0043 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0029 0.059
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0529
Brugia malayi mbt repeat family protein 0.0046 0.0106 0.1494
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.0151 0.3149
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0323 0.3621
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0262
Brugia malayi jmjC domain containing protein 0.0025 0.0039 0.0542
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0055 0.0134 0.0134
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0126 0.2636
Plasmodium vivax phosphoglycerate kinase, putative 0.0166 0.0476 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0071 0.0182 0.0333
Mycobacterium tuberculosis Conserved protein 0.0035 0.0071 0.0035
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0054 0.013 0.1829
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0279 0.0827 0.6915
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0034 0.0069 0.0773
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0795
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0033 0.0667
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0231 0.0678 0.1243
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0032
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0055 0.0134 0.2798
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0055 0.0134 0.0163
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0166 0.0476 1
Plasmodium vivax protein arginine N-methyltransferase 5, putative 0.0061 0.0152 0.3175
Echinococcus multilocularis sentrin specific protease 7 0.0013 0.0002 0.0002
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0142 0.0403 0.0739
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0071 0.0071
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0022 0.0029 0.059
Mycobacterium ulcerans isocitrate lyase Icl 0.0627 0.1907 0.3624
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0029 0.0246
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0049 0.0115 0.2384
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0054 0.013 0.2711
Loa Loa (eye worm) hypothetical protein 0.0197 0.0573 0.642
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0029 0.059
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0003 0.0032
Trypanosoma brucei calcium-transporting ATPase, putative 0.0034 0.0069 0.1425
Leishmania major arginine N-methyltransferase, type II, putative;with=GeneDB:Tb927.10.640 0.0039 0.0084 0.1738
Loa Loa (eye worm) hypothetical protein 0.0242 0.0711 0.7962
Brugia malayi beta-lactamase family protein 0.0035 0.0071 0.0998
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0039 0.0068
Brugia malayi Membrane calcium atpase protein 3 0.0054 0.013 0.1829
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1624 0.4995 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0051 0.1038
Brugia malayi PHD-finger family protein 0.0029 0.0051 0.0713
Leishmania major hypothetical protein, conserved 0.0025 0.0041 0.0829
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0039 0.0068
Plasmodium falciparum plasmepsin II 0.0071 0.0182 0.3816
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.038 0.5345
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0279 0.0827 0.1518
Leishmania major hypothetical protein, conserved 0.0022 0.0029 0.059
Trypanosoma brucei arginine N-methyltransferase, type II 0.0039 0.0084 0.1738
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0054 0.013 0.0236
Schistosoma mansoni ATPase 0.0049 0.0115 0.0208
Loa Loa (eye worm) hypothetical protein 0.0125 0.035 0.3922
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0166 0.0476 0.0794
Brugia malayi E1-E2 ATPase family protein 0.0032 0.0061 0.0857
Loa Loa (eye worm) E1-E2 ATPase 0.0027 0.0045 0.0508
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0071 0.0594
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0022 0.0029 0.0051
Schistosoma mansoni zinc finger protein 0.0022 0.0029 0.0051
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0146 0.018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0146 0.0266
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0166 0.0476 1
Schistosoma mansoni jumonji domain containing protein 0.0132 0.0371 0.0679
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0071 0.1475
Schistosoma mansoni hypothetical protein 0.03 0.0893 0.1639
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0027 0.0222
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0454 0.0454
Loa Loa (eye worm) MBCTL1 0.0053 0.0126 0.1412
Onchocerca volvulus 0.0046 0.0106 0.1269
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0054 0.013 0.013
Brugia malayi Bromodomain containing protein 0.0029 0.0051 0.0713
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0071 0.1475
Brugia malayi hypothetical protein 0.0125 0.035 0.4926
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0142 0.0403 0.0739
Loa Loa (eye worm) Skb1 methyltransferase 0.0061 0.0152 0.1702
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0126 0.1055
Plasmodium falciparum plasmepsin VII 0.0071 0.0182 0.3816
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0795
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0555
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0039 0.0431
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0071 0.0034
Brugia malayi Phosphoglycerate kinase 0.0166 0.0476 0.6688
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.0055 0.0134 0.0124
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0054 0.013 0.013
Mycobacterium leprae Isocitrate lyase 0.0294 0.0874 0.1575
Echinococcus granulosus nervana 2 0.0279 0.0827 0.6915
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0151 0.3149
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0071 0.1475
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0156 0.1302
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0029 0.0029
Loa Loa (eye worm) hhat protein 0.0022 0.0029 0.033
Loa Loa (eye worm) Ulp1 protease 0.0065 0.0164 0.1831
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0071 0.1475
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0054 0.013 0.0236
Plasmodium falciparum plasmepsin VI 0.0071 0.0182 0.3816
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0049 0.0115 0.0958
Mycobacterium ulcerans hypothetical protein 0.0035 0.0071 0.0034
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0041 0.0829
Brugia malayi MBOAT family protein 0.0022 0.0029 0.0414
Schistosoma mansoni cpg binding protein 0.0028 0.0049 0.0087
Echinococcus granulosus sentrin specific protease 1 0.0013 0.0002 0.0013
Schistosoma mansoni hypothetical protein 0.0062 0.0156 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0245 0.0448
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0002 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0245 0.0448
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0027 0.0045 0.0508
Echinococcus granulosus calcium transporting atpase 0.0054 0.013 0.1088
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0071 0.1466
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0022 0.0029 0.0029
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0029 0.059
Plasmodium falciparum phd finger protein, putative 0.0029 0.0051 0.1038
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0085 0.0085
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0054 0.013 0.2711
Schistosoma mansoni hypothetical protein 0.0062 0.0156 0.0284
Leishmania major hypothetical protein, conserved 0.0025 0.0039 0.0781
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0166 0.0476 1
Brugia malayi Skb1 methyltransferase family protein 0.0061 0.0152 0.2138
Leishmania major calcium-transporting ATPase, putative 0.0054 0.013 0.2711
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0051 0.1038
Plasmodium vivax importin-beta 2, putative 0.0028 0.005 0.1015
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0151 0.043 0.3598
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0054 0.013 0.2711
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0034 0.0069 0.0971
Leishmania major phosphoglycerate kinase B, cytosolic 0.0166 0.0476 1
Echinococcus multilocularis geminin 0.0331 0.0989 0.0989
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0156 0.1302
Entamoeba histolytica hypothetical protein, conserved 0.0022 0.0029 0.059
Trypanosoma cruzi hypothetical protein 0.0065 0.0164 0.3418
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0146 0.0265
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0029 0.033
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0071 0.1475
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0125 0.035 0.3922
Echinococcus granulosus lysine specific demethylase 5A 0.0094 0.0253 0.2114
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0156 0.0156
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0039 0.0068
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0029 0.059
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0106 0.0193
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0029 0.0051
Brugia malayi MH2 domain containing protein 0.0116 0.0323 0.4548
Echinococcus multilocularis protein arginine N methyltransferase 5 0.0061 0.0152 0.0152
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0123 0.0343 0.4816
Entamoeba histolytica vacuolar protein sorting 26 0.0022 0.0029 0.059
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0123 0.0343 0.3834
Trypanosoma brucei calcium-translocating P-type ATPase 0.0054 0.013 0.2711
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0071 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0245 0.0245
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0022 0.0029 0.0246
Schistosoma mansoni shk1 kinase-binding protein 0.0061 0.0152 0.0277
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0041 0.0829
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0071 0.1475
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0071 0.0035
Echinococcus multilocularis lysine specific demethylase 5A 0.0092 0.0248 0.0248
Echinococcus granulosus nervana 2 0.0279 0.0827 0.6915
Echinococcus granulosus phosphoglycerate kinase 1 0.0166 0.0476 0.3977
Onchocerca volvulus 0.0279 0.0827 1
Schistosoma mansoni hypothetical protein 0.0062 0.0156 0.0284
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) 0.0627 0.1907 0.3602
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0627 0.1907 0.375
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.0893 1
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0039 0.0322
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0022 0.0029 0.059
Leishmania major hypothetical protein, conserved 0.0035 0.0071 0.1466
Echinococcus granulosus importin subunit beta 1 0.0028 0.005 0.0415
Loa Loa (eye worm) hypothetical protein 0.02 0.0582 0.6514
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0156 0.1744
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0022 0.0029 0.0029
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0231 0.0678 0.5666
Schistosoma mansoni sterol O-acyltransferase 1 0.0222 0.0649 0.119
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0022 0.0029 0.0029
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0029 0.059
Echinococcus granulosus jumonji domain containing protein 0.004 0.0085 0.0714
Loa Loa (eye worm) hypothetical protein 0.0062 0.0156 0.1744
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0126 0.1774
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0055 0.0134 0.2798
Loa Loa (eye worm) hypothetical protein 0.0071 0.0182 0.2043
Loa Loa (eye worm) hypothetical protein 0.0088 0.0236 0.264
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0051 0.1038
Toxoplasma gondii ABC1 family protein 0.0035 0.0071 0.1466
Loa Loa (eye worm) hypothetical protein 0.0049 0.0115 0.1282
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0039 0.0431
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0049 0.0115 0.2384
Loa Loa (eye worm) hypothetical protein 0.0034 0.0069 0.0773
Trichomonas vaginalis ran, putative 0.0021 0.0027 0.0529
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0166 0.0476 0.0854
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0055 0.0134 0.2798
Echinococcus granulosus sterol O acyltransferase 1 0.0222 0.0649 0.5426
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0197 0.0573 0.642
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0049 0.0115 0.2384
Echinococcus multilocularis cpg binding protein 0.003 0.0054 0.0054
Trichomonas vaginalis shk1 kinase-binding protein, putative 0.0039 0.0084 0.1738
Onchocerca volvulus 0.0137 0.0388 0.4682
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0071 0.0128
Plasmodium falciparum plasmepsin V 0.0071 0.0182 0.3816
Mycobacterium ulcerans isocitrate lyase AceAb 0.0627 0.1907 0.3624
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0065 0.0164 0.3418
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0054 0.013 0.1088
Trichomonas vaginalis cation-transporting ATPase, putative 0.0049 0.0115 0.2384
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0151 0.3149
Schistosoma mansoni phosphoglycerate kinase 0.0166 0.0476 0.0872
Plasmodium falciparum plasmepsin IX 0.0071 0.0182 0.3816
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0279 0.0827 0.0827
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0027 0.0529
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0279 0.0827 0.6915
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0071 0.1466
Plasmodium vivax plasmepsin V, putative 0.0071 0.0182 0.3816
Onchocerca volvulus 0.0049 0.0115 0.1377
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0039 0.0322
Echinococcus granulosus geminin 0.0331 0.0989 0.8273
Toxoplasma gondii aspartyl protease ASP1 0.0071 0.0182 0.3816
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0049 0.0115 0.2384
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0071 0.0182 0.0333
Brugia malayi MBOAT family protein 0.0022 0.0029 0.0414
Loa Loa (eye worm) hypothetical protein 0.0071 0.0182 0.2043
Leishmania major glycerol uptake protein, putative 0.0022 0.0029 0.059
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) 0.168 0.5167 1
Plasmodium falciparum calcium-transporting ATPase 0.0054 0.013 0.2711
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0071 0.1475
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0029 0.0051
Schistosoma mansoni hypothetical protein 0.0062 0.0156 0.0284
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0071 0.0035
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0126 0.0126
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.0253 0.283
Entamoeba histolytica hypothetical protein 0.0022 0.0029 0.059
Echinococcus multilocularis sterol O acyltransferase 1 0.0222 0.0649 0.0649
Echinococcus granulosus Na:K ATPase alpha subunit 0.0142 0.0403 0.3374
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0054 0.013 0.2711
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0017
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0055 0.0134 0.1122
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0529
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0118 0.0327 0.0502
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0049 0.0115 0.2384
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0071 0.0182 0.0333
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0041 0.0829
Echinococcus granulosus peregrin 0.0029 0.0051 0.0424
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0071 0.0597
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0027 0.0045 0.0926
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0142 0.0403 0.0403
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0034 0.0069 0.1425
Brugia malayi hypothetical protein 0.0071 0.0182 0.2565
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0071 0.0182 0.1526
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0245 0.205
Onchocerca volvulus 0.0092 0.0247 0.2969
Brugia malayi jmjC domain containing protein 0.0151 0.043 0.605
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0071 0.1466
Plasmodium vivax aspartyl protease, putative 0.0071 0.0182 0.3816
Schistosoma mansoni hypothetical protein 0.0282 0.0837 0.1536
Brugia malayi jmjC domain containing protein 0.0025 0.0039 0.0542
Echinococcus granulosus protein arginine N methyltransferase 5 0.0061 0.0152 0.1272
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0197 0.0573 0.8063
Schistosoma mansoni alpha-glucosidase 0.0136 0.0385 0.0706
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0245 0.205
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0022 0.0032 0.0634
Plasmodium vivax calcium-transporting ATPase, putative 0.0054 0.013 0.2711
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0071 0.0182 0.3816
Loa Loa (eye worm) hhat protein 0.0022 0.0029 0.033
Plasmodium falciparum plasmepsin IV 0.0071 0.0182 0.3816
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0071 0.0795
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0003 0.0032
Brugia malayi Importin beta-1 subunit 0.0028 0.005 0.0698
Brugia malayi MBOAT family protein 0.0022 0.0029 0.0414
Plasmodium vivax P-type ATPase4, putative 0.0054 0.013 0.2711
Plasmodium falciparum phosphoglycerate kinase 0.0166 0.0476 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0027 0.0045 0.0926
Brugia malayi calcium ATPase 0.0027 0.0045 0.0639
Plasmodium falciparum plasmepsin VIII, putative 0.0071 0.0182 0.3816
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0795
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.0253 0.0462
Loa Loa (eye worm) hypothetical protein 0.0071 0.0182 0.2043
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0454 0.638
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0627 0.1907 0.375
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.1196 0.1196
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0071 0.0035
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.168 0.5167 1
Treponema pallidum phosphoglycerate kinase 0.0166 0.0476 1
Echinococcus multilocularis peregrin 0.0029 0.0051 0.0051
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0146 0.018
Leishmania major GTP-binding protein, putative 0.0021 0.0027 0.0529
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0049 0.0115 0.0115
Echinococcus granulosus o acyltransferase membrane bound domain 0.0022 0.0029 0.0246
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0027 0.0045 0.0639
Plasmodium falciparum plasmepsin X 0.0071 0.0182 0.3816
Schistosoma mansoni cpg binding protein 0.003 0.0054 0.0096
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0142 0.0403 0.4517
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0126 0.1055
Echinococcus granulosus sentrin specific protease 7 0.0013 0.0002 0.0013
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0454 0.0454
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0156 0.219
Trichomonas vaginalis cation-transporting ATPase, putative 0.0049 0.0115 0.2384
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0055 0.0134 0.2798
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0049 0.0115 0.2384
Onchocerca volvulus 0.0071 0.0182 0.2192
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0054 0.013 0.013
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0051 0.0091
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0071 0.0182 0.3816
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0071 0.1466
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0022 0.0029 0.0051
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.005 0.1015
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0022 0.0029 0.0029
Brugia malayi MBOAT family protein 0.0022 0.0029 0.0414
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0003 0.0032
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0146 0.1217
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0033 0.0667
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0055 0.0134 0.2798
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0032 0.0061 0.1253
Leishmania major calcium motive p-type ATPase, putative 0.0054 0.013 0.2711
Giardia lamblia PHD finger protein 15 0.0029 0.0051 0.1038
Brugia malayi Na,K-ATPase alpha subunit 0.0142 0.0403 0.5673
Schistosoma mansoni alpha glucosidase 0.0035 0.0071 0.0129
Onchocerca volvulus 0.0231 0.0678 0.819
Toxoplasma gondii hypothetical protein 0.0022 0.0029 0.059
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0049 0.0115 0.2384
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0049 0.0115 0.2384
Plasmodium vivax plasmepsin IV, putative 0.0071 0.0182 0.3816
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0071 0.0182 0.0333
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0025 0.0041 0.0457
Plasmodium falciparum plasmepsin I 0.0071 0.0182 0.3816
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0054 0.013 0.0236
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0656 0.1219
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0003 0.0032
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0003 0.0018
Loa Loa (eye worm) MBOAT family protein 0.0022 0.0029 0.033
Brugia malayi Hhat protein 0.0022 0.0029 0.0414
Loa Loa (eye worm) hypothetical protein 0.0222 0.0649 0.7264
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0071 0.0182 0.2043
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0022 0.0029 0.033
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0071 0.1466
Leishmania major importin beta-1 subunit, putative 0.0023 0.0033 0.0667
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.0711 0.5947
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0106 0.0889
Loa Loa (eye worm) hypothetical protein 0.0111 0.0305 0.3414
Loa Loa (eye worm) beta-lactamase 0.0035 0.0071 0.0795
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0039 0.0781
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0027 0.0045 0.0926
Onchocerca volvulus Huntingtin homolog 0.0125 0.035 0.4226
Loa Loa (eye worm) calcium ATPase 0.0027 0.0047 0.0527
Schistosoma mansoni hypothetical protein 0.0049 0.0115 0.0209
Onchocerca volvulus 0.0022 0.0029 0.0339
Toxoplasma gondii P-type ATPase PMA1 0.0027 0.0045 0.0926
Brugia malayi Eukaryotic aspartyl protease family protein 0.0071 0.0182 0.2565
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0051 0.0568
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0039 0.0039
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0146 0.0186
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0022 0.0029 0.0029
Brugia malayi jmjC domain containing protein 0.0025 0.0039 0.0542
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0022 0.0029 0.0051
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0027 0.0045 0.0926
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.0711 0.0711
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0454 0.5079
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0298
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0013 0.0021
Schistosoma mansoni hypothetical protein 0.0398 0.1196 0.2196
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0071 0.0182 0.0333
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0017
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0049 0.0115 0.2384
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0071 0.1466
Trypanosoma cruzi P-type H+-ATPase, putative 0.0027 0.0045 0.0926
Schistosoma mansoni memapsin-2 (A01 family) 0.1768 0.5441 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0071 0.0182 0.0333
Loa Loa (eye worm) hypothetical protein 0.0279 0.0827 0.9258
Loa Loa (eye worm) hypothetical protein 0.0022 0.0029 0.033
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0151 0.3149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0245 0.0448
Schistosoma mansoni cathepsin D (A01 family) 0.0071 0.0182 0.0333
Loa Loa (eye worm) hypothetical protein 0.0064 0.0161 0.1807
Brugia malayi beta-lactamase 0.0035 0.0071 0.0998
Trypanosoma brucei glycerol uptake protein, putative 0.0022 0.0029 0.059
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0003 0.0032
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0071 0.0182 0.0182
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0231 0.0678 0.1243
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0374
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0279 0.0827 0.0827
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.005 0.1015
Brugia malayi RNA, U transporter 1 0.008 0.021 0.2958
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0049 0.0115 0.2384
Echinococcus multilocularis GPCR, family 2 0.0062 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0508
Brugia malayi hypothetical protein 0.0025 0.0041 0.0574
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0026 0.0043 0.0364
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0039 0.0781
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0071 0.0998
Trichomonas vaginalis porcupine, putative 0.0022 0.0029 0.059
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0071 0.0034
Trypanosoma brucei phosphoglycerate kinase 0.0166 0.0476 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0003 0.0032
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0049 0.0115 0.2384
Loa Loa (eye worm) hypothetical protein 0.0095 0.0258 0.2887
Mycobacterium tuberculosis Conserved protein 0.0035 0.0071 0.0035
Brugia malayi beta-lactamase family protein 0.0035 0.0071 0.0998
Echinococcus multilocularis nervana 2 0.0231 0.0678 0.0678
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0065 0.0164 0.23
Leishmania major phosphoglycerate kinase C, glycosomal 0.0166 0.0476 1
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0022 0.0029 0.0246
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0126 0.0126
Brugia malayi Pepsin A precursor 0.0071 0.0182 0.2565
Trichomonas vaginalis Sentrin-specific protease, putative 0.0065 0.0164 0.3418
Toxoplasma gondii P-type ATPase4, putative 0.0054 0.013 0.2711
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0065 0.0164 0.3418
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0054 0.013 0.2711
Loa Loa (eye worm) hypothetical protein 0.0135 0.038 0.4255
Trypanosoma brucei P-type H+-ATPase, putative 0.0027 0.0045 0.0926
Echinococcus multilocularis nervana 2 0.0279 0.0827 0.0827
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0151 0.3149
Brugia malayi CXXC zinc finger family protein 0.0028 0.0049 0.0689
Loa Loa (eye worm) hypothetical protein 0.0279 0.0827 0.9258
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0795
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0146 0.3038
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0071 0.0035
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0071 0.1466
Echinococcus multilocularis importin subunit beta 1 0.0028 0.005 0.005
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0166 0.0476 1
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0022 0.0029 0.0051
Plasmodium vivax aspartyl proteinase, putative 0.0071 0.0182 0.3816
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0071 0.1475
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0049 0.0115 0.2384
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.005 0.1015
Echinococcus granulosus GPCR family 2 0.0062 0.0156 0.1302
Schistosoma mansoni hypothetical protein 0.0331 0.0989 0.1816
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0022 0.0029 0.059
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0431
Schistosoma mansoni cathepsin D (A01 family) 0.0071 0.0182 0.0333
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0033 0.0667
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0071 0.0182 0.0333
Trypanosoma cruzi P-type H+-ATPase, putative 0.0027 0.0045 0.0926
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0071 0.0182 0.3816
Trypanosoma brucei glucosidase, putative 0.0035 0.0071 0.1475
Toxoplasma gondii aspartyl protease ASP3 0.0071 0.0182 0.3816
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0013 0.0002 0.0021
Echinococcus granulosus phd:f box containing protein 0.0025 0.0039 0.0322
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0071 0.0035
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0065 0.0164 0.0298
Mycobacterium ulcerans phosphoglycerate kinase 0.0166 0.0476 0.0825
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0022 0.0029 0.0051
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0134 0.0163
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0055 0.0134 0.1502
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0049 0.0115 0.2384
Echinococcus multilocularis sentrin specific protease 1 0.0013 0.0002 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0145 0.1621
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0027 0.0047 0.0961
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0106 0.0193
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0279 0.0827 0.6915
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0027 0.0047 0.0662
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0049 0.0115 0.2384
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0156 0.219
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0071 0.0128
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0054 0.013 0.2711
Leishmania major P-type H -ATPase, putative 0.0027 0.0045 0.0926
Entamoeba histolytica Ran family GTPase 0.0021 0.0027 0.0529
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0049 0.0115 0.2384
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0027 0.0529
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0245 0.0245
Echinococcus multilocularis phosphoglycerate kinase 1 0.0166 0.0476 0.0476
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0055 0.0134 0.2798
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0039 0.0039
Echinococcus granulosus cpg binding protein 0.003 0.0054 0.0451
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0115 0.1619
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0071 0.1475
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0071 0.1466
Entamoeba histolytica Skb1 methyltransferase, putative 0.0061 0.0152 0.3175
Onchocerca volvulus Alhambra homolog 0.0029 0.0051 0.0596
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0795
Schistosoma mansoni hypothetical protein 0.0331 0.0989 0.1816
Schistosoma mansoni alpha-glucosidase 0.0136 0.0385 0.0706
Trypanosoma brucei glycerol uptake protein, putative 0.0022 0.0029 0.059
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0055 0.0134 0.2798
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0071 0.0182 0.2043
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0071 0.1475
Leishmania major glycerol uptake protein, putative 0.0022 0.0029 0.059
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0279 0.0827 0.0827
Echinococcus granulosus nervana 2 0.0231 0.0678 0.5666
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0262
Entamoeba histolytica hypothetical protein 0.0023 0.0033 0.0667
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0049 0.0115 0.2384
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0039 0.0781
Schistosoma mansoni hypothetical protein 0.0135 0.038 0.0696
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0106 0.119
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0003 0.0043
Trichomonas vaginalis cation-transporting ATPase, putative 0.0049 0.0115 0.2384
Echinococcus multilocularis nervana 2 0.0279 0.0827 0.0827
Giardia lamblia Phosphoglycerate kinase 0.0166 0.0476 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0041 0.0829
Brugia malayi jmjC domain containing protein 0.0094 0.0253 0.3555
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0054 0.013 0.2711
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.0529 0.0529
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0054 0.013 0.0236
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0022 0.0032 0.0634
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0071 0.1475
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0022 0.0029 0.059
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0166 0.0476 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0071 0.1475
Trypanosoma cruzi P-type H+-ATPase, putative 0.0027 0.0045 0.0926
Brugia malayi calcium ATPase 0.0027 0.0047 0.0662
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0146 0.0265
Onchocerca volvulus 0.0071 0.0182 0.2192
Mycobacterium tuberculosis Conserved protein 0.0035 0.0071 0.0035
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0049 0.0115 0.2384
Loa Loa (eye worm) hypothetical protein 0.0035 0.0071 0.0795
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0245 0.2745
Trypanosoma brucei P-type H+-ATPase, putative 0.0027 0.0045 0.0926
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0029 0.059
Loa Loa (eye worm) hypothetical protein 0.0046 0.0106 0.119
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.0151 0.3149
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0027 0.0529
Trichomonas vaginalis shk1 kinase-binding protein, putative 0.0039 0.0084 0.1738
Schistosoma mansoni ran 0.0021 0.0027 0.0046
Toxoplasma gondii histone arginine methyltransferase PRMT5 0.0061 0.0152 0.3175
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.0529 0.4426
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0166 0.0476 0.5
Onchocerca volvulus 0.0035 0.0071 0.0842
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0039 0.0322
Brugia malayi Calcitonin receptor-like protein seb-1 0.0197 0.0573 0.8063
Brugia malayi hypothetical protein 0.0071 0.0182 0.2565
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0071 0.0182 0.0333
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0051 0.0424
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0568
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0022 0.0029 0.0246
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0022 0.0029 0.0246
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0039 0.0781
Trypanosoma cruzi glycerol uptake protein, putative 0.0022 0.0029 0.059
Leishmania major glycerol uptake protein, putative 0.0022 0.0029 0.059
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0106 0.0889
Schistosoma mansoni cpg binding protein 0.003 0.0054 0.0096
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0027 0.0529
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0071 0.1475
Trichomonas vaginalis transmembrane protein nessy, putative 0.0022 0.0029 0.059
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0041 0.0829

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.622 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.431 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.298 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.141 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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