Detailed information for compound 182149

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 467.988 | Formula: C26H30ClN3O3
  • H donors: 0 H acceptors: 1 LogP: 6.02 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccccc1c1noc(c1)N(Cc1ccc2c(c1)OCO2)CCCN1CCCCCC1
  • InChi: 1S/C26H30ClN3O3/c27-22-9-4-3-8-21(22)23-17-26(33-28-23)30(15-7-14-29-12-5-1-2-6-13-29)18-20-10-11-24-25(16-20)32-19-31-24/h3-4,8-11,16-17H,1-2,5-7,12-15,18-19H2
  • InChiKey: FRLMPPRHWCNHEX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor II (thrombin) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis adam 0.0056 0.0045 0.0056
Schistosoma mansoni growth factor receptor-bound protein 0.026 0.0316 0.0316
Echinococcus multilocularis epidermal growth factor receptor 0.0727 0.0937 0.1173
Toxoplasma gondii subtilisin SUB9 0.0334 0.0414 0.8771
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0038 0.0048
Echinococcus granulosus protein arginine N methyltransferase 7 0.007 0.0063 0.0063
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0027 0.0006 0.0007
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.007 0.0063 0.0104
Loa Loa (eye worm) hypothetical protein 0.0085 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0134 0.0148 0.0148
Echinococcus granulosus C type lectin domian containing protein 0.0039 0.0022 0.0022
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0101 0.0166
Brugia malayi protein kinase C II. 0.0099 0.0101 0.0101
Brugia malayi SWIRM domain containing protein 0.0035 0.0017 0.0017
Brugia malayi neuroendocrine convertase 1 precursor 0.4769 0.6315 0.6315
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1267 0.1656 0.1656
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0019 0.0019
Onchocerca volvulus 0.0051 0.0038 0.0668
Onchocerca volvulus 0.0051 0.0038 0.0668
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0006 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Toxoplasma gondii PA14 domain-containing protein 0.0051 0.0038 0.0812
Brugia malayi hypothetical protein 0.0039 0.0022 0.0022
Toxoplasma gondii bicoid-interacting protein BIN3 0.007 0.0063 0.1342
Toxoplasma gondii subtilisin SUB4 0.0334 0.0414 0.8771
Onchocerca volvulus 0.0039 0.0022 0.0379
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0000034698 0.0000034698
Echinococcus granulosus chromatin regulatory protein sir2 0.0669 0.086 0.086
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1511 0.1981 0.3242
Onchocerca volvulus 0.0039 0.0022 0.0379
Trypanosoma brucei subtilisin peptidase 0.0334 0.0414 0.4663
Brugia malayi Kringle domain containing protein 0.0051 0.0038 0.0038
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0101 0.0166
Schistosoma mansoni hypothetical protein 0.1511 0.1981 0.1981
Brugia malayi ADAM-TS Spacer 1 family protein 0.0025 0.0003 0.0003
Schistosoma mansoni site-1 peptidase (S08 family) 0.0334 0.0414 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0669 0.086 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0051 0.0038 0.0733
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1845 0.2425 0.3969
Leishmania major silent information regulator 2, putative 0.0669 0.086 1
Toxoplasma gondii aspartyl protease 0.0037 0.0019 0.0403
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0334 0.0414 0.0414
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0334 0.0414 1
Brugia malayi CUB domain containing protein 0.003 0.001 0.001
Brugia malayi hypothetical protein 0.0037 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0054 0.0041 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.1511 0.1981 0.3242
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0125 0.0136 0.2604
Schistosoma mansoni hypothetical protein 0.0096 0.0098 0.0098
Echinococcus multilocularis serine:threonine protein kinase N2 0.0091 0.0091 0.0114
Schistosoma mansoni hypothetical protein 0.0051 0.0038 0.0038
Echinococcus granulosus neuroendocrine convertase 2 0.4769 0.6315 0.6315
Echinococcus granulosus furin 0.7539 1 1
Brugia malayi Furin-like cysteine rich region family protein 0.0727 0.0937 0.0937
Brugia malayi transcriptional regulator, Sir2 family protein 0.0669 0.086 0.086
Echinococcus granulosus epidermal growth factor receptor 0.0727 0.0937 0.0937
Plasmodium falciparum plasmepsin VIII, putative 0.0037 0.0019 0.0365
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0101 0.0166
Trichomonas vaginalis hypothetical protein 0.0051 0.0038 0.0063
Brugia malayi hypothetical protein 0.0039 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0039 0.0022 0.0022
Brugia malayi astacin protease protein 30 0.003 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0454 0.0574 0.0574
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0101 0.0166
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0419 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0017
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0099 0.0101 0.0127
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0035 0.0017 0.0021
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0334 0.0414 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0019 0.0019
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0099 0.0101 0.0768
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0669 0.086 1
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0125 0.0136 0.017
Loa Loa (eye worm) DPY-31 protein 0.003 0.001 0.001
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0035 0.0017 0.0017
Brugia malayi hypothetical protein 0.0039 0.0022 0.0022
Plasmodium falciparum plasmepsin IX 0.0037 0.0019 0.0365
Echinococcus granulosus membrane bound transcription factor site 1 0.0334 0.0414 0.0414
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0039 0.0023 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0025 0.0041
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0037 0.0019 0.0403
Trypanosoma brucei protein arginine n-methyltransferase 7 0.007 0.0063 0.0457
Plasmodium vivax subtilisin-like serine protease, putative 0.0334 0.0414 0.7946
Plasmodium falciparum apical sushi protein 0.0039 0.0022 0.0417
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0195 0.0229 0.2665
Loa Loa (eye worm) DEAH box polypeptide 35 0.0034 0.0015 0.0015
Plasmodium falciparum LCCL domain-containing protein 0.0051 0.0038 0.0735
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.003 0.001 0.001
Echinococcus granulosus MAM 0.0096 0.0098 0.0098
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0099 0.0101 0.1178
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.007 0.0063 0.0104
Schistosoma mansoni hypothetical protein 0.007 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0039 0.0022 0.0022
Brugia malayi hypothetical protein 0.0096 0.0098 0.0098
Echinococcus granulosus protein will die slowly 0.0207 0.0245 0.0245
Loa Loa (eye worm) TK/ALK protein kinase 0.0096 0.0098 0.0098
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0669 0.086 0.1407
Brugia malayi hypothetical protein 0.0056 0.0045 0.0045
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Echinococcus granulosus lysine specific histone demethylase 1A 0.0085 0.0083 0.0083
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0019 0.0019
Onchocerca volvulus 0.003 0.001 0.0182
Brugia malayi NAD-dependent deacetylase SIRT1 0.0099 0.0101 0.0101
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0099 0.0101 0.0101
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0019 0.0019
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0099 0.0101 0.0101
Plasmodium vivax aspartyl protease, putative 0.0037 0.0019 0.0365
Loa Loa (eye worm) reprolysin 0.0043 0.0027 0.0027
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.007 0.0063 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0003 0.0003
Schistosoma mansoni growth factor receptor-bound protein 0.026 0.0316 0.0316
Plasmodium falciparum plasmepsin V 0.0414 0.0521 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0019 0.0019
Giardia lamblia High cysteine membrane protein Group 2 0.277 0.3655 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0101 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Loa Loa (eye worm) transcriptional regulator 0.0099 0.0101 0.0101
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1511 0.1981 0.3242
Leishmania major arginine N-methyltransferase-like protein 0.0125 0.0136 0.1187
Onchocerca volvulus 0.0454 0.0574 1
Trichomonas vaginalis conserved hypothetical protein 0.0334 0.0414 0.0678
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Toxoplasma gondii subtilisin SUB10 0.0334 0.0414 0.8771
Loa Loa (eye worm) Carm1-pending protein 0.007 0.0063 0.0063
Plasmodium falciparum plasmepsin VI 0.0037 0.0019 0.0365
Schistosoma mansoni SWI/SNF complex-related 0.0035 0.0017 0.0017
Toxoplasma gondii subtilisin SUB2 0.0334 0.0414 0.8771
Trichomonas vaginalis conserved hypothetical protein 0.1511 0.1981 0.3242
Trypanosoma cruzi UDP-galactopyranose mutase 0.0085 0.0083 0.0967
Plasmodium vivax aspartyl protease, putative 0.0037 0.0019 0.0365
Loa Loa (eye worm) transcriptional regulator 0.0669 0.086 0.086
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0195 0.0229 0.2665
Toxoplasma gondii histone deacetylase SIR2 0.0099 0.0101 0.2144
Brugia malayi hypothetical protein 0.0039 0.0022 0.0022
Onchocerca volvulus 0.0096 0.0098 0.1705
Giardia lamblia Hypothetical protein 0.0669 0.086 0.2316
Brugia malayi CUB domain containing protein 0.003 0.001 0.001
Entamoeba histolytica SWIRM domain protein 0.0035 0.0017 0.0199
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0037 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0195 0.0229 0.2665
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0083 0.1595
Onchocerca volvulus 0.0216 0.0258 0.4491
Echinococcus multilocularis tissue type plasminogen activator 0.0051 0.0038 0.0048
Loa Loa (eye worm) sex muscle abnormal protein 5 0.026 0.0316 0.0316
Onchocerca volvulus 0.0096 0.0098 0.1705
Toxoplasma gondii histone deacetylase SIR2-like 0.0099 0.0101 0.2144
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0364 0.0455 0.5147
Onchocerca volvulus 0.0037 0.0019 0.0332
Brugia malayi Angiotensin-converting enzyme family protein 0.0681 0.0876 0.0876
Echinococcus multilocularis discoidin domain receptor 0.0051 0.0038 0.0048
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1845 0.2425 0.3969
Trichomonas vaginalis conserved hypothetical protein 0.1511 0.1981 0.3242
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0334 0.0414 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Loa Loa (eye worm) CUB domain-containing protein 0.003 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0099 0.0101 0.0101
Loa Loa (eye worm) aspartyl protease 6 0.0037 0.0019 0.0019
Brugia malayi Eukaryotic aspartyl protease family protein 0.0037 0.0019 0.0019
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0051 0.0038 0.0048
Toxoplasma gondii subtilisin SUB5 0.0334 0.0414 0.8771
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0085 0.0083 0.1193
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1845 0.2425 0.3969
Toxoplasma gondii SWIRM domain-containing protein 0.0035 0.0017 0.0363
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.007 0.0063 0.0104
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0334 0.0414 1
Giardia lamblia Furin precursor putative serine protease 0.1511 0.1981 0.5398
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0037 0.0019 0.0031
Plasmodium falciparum LCCL domain-containing protein 0.0051 0.0038 0.0735
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0038 0.0048
Plasmodium falciparum subtilisin-like protease 3 0.0334 0.0414 0.7946
Echinococcus multilocularis CUB 0.003 0.001 0.0013
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0085 0.0083 0.1595
Toxoplasma gondii subtilisin SUB1 0.0334 0.0414 0.8771
Brugia malayi Calcium binding EGF domain containing protein 0.0045 0.003 0.003
Echinococcus granulosus cubilin 0.003 0.001 0.001
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0099 0.0101 0.1942
Plasmodium falciparum cysteine repeat modular protein 1 0.0051 0.0038 0.0733
Loa Loa (eye worm) sirtuin 4 0.0099 0.0101 0.0101
Loa Loa (eye worm) subtilase 0.0334 0.0414 0.0414
Loa Loa (eye worm) proprotein convertase 2 0.1845 0.2425 0.2425
Schistosoma mansoni atypical protein kinase C 0.0026 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0334 0.0414 0.0678
Loa Loa (eye worm) hypothetical protein 0.0039 0.0022 0.0022
Plasmodium falciparum plasmepsin VII 0.0037 0.0019 0.0365
Plasmodium falciparum subtilisin-like protease 2 0.0334 0.0414 0.7946
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0125 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0056 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0017 0.0028
Mycobacterium leprae Possible secreted protease 0.0334 0.0414 1
Echinococcus multilocularis protein kinase c iota type 0.0026 0.0004 0.0005
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1845 0.2425 0.2425
Echinococcus multilocularis 0.0085 0.0083 0.0104
Trichomonas vaginalis hypothetical protein 0.1511 0.1981 0.3242
Brugia malayi SWIRM domain containing protein 0.0454 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.7539 1 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0101 0.0166
Onchocerca volvulus 0.0039 0.0022 0.0379
Echinococcus granulosus protein arginine methyltransferase 0.0125 0.0136 0.0136
Onchocerca volvulus 0.0039 0.0022 0.0379
Schistosoma mansoni hypothetical protein 0.003 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.1511 0.1981 0.3242
Echinococcus multilocularis cubilin 0.003 0.001 0.0013
Loa Loa (eye worm) kelch domain-containing protein family protein 0.003 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0019 0.0019
Trypanosoma cruzi UDP-galactopyranose mutase 0.0085 0.0083 0.0967
Onchocerca volvulus 0.0207 0.0245 0.4267
Schistosoma mansoni discoidin domain receptor 0.0051 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.003 0.001 0.001
Brugia malayi Carm1-pending protein 0.007 0.0063 0.0063
Plasmodium vivax plasmepsin IV, putative 0.0037 0.0019 0.0365
Toxoplasma gondii subtilisin SUB11 0.0334 0.0414 0.8771
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Brugia malayi angiogenesis inhibito 0.0025 0.0003 0.0003
Brugia malayi Protein kinase domain containing protein 0.0042 0.0025 0.0025
Plasmodium vivax aspartyl protease, putative 0.0037 0.0019 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.1511 0.1981 0.3242
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0334 0.0414 1
Onchocerca volvulus 0.0039 0.0022 0.0379
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0364 0.0455 0.529
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0101 0.1942
Treponema pallidum hypothetical protein 0.0023 0 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1845 0.2425 0.3969
Brugia malayi hypothetical protein 0.0085 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0334 0.0414 0.0678
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0125 0.0136 0.0136
Brugia malayi amine oxidase, flavin-containing family protein 0.012 0.013 0.013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Schistosoma mansoni hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0037 0.0019 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0038 0.0812
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.007 0.0063 0.0306
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0681 0.0876 0.0876
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0669 0.086 1
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0079 0.0074 0.0074
Echinococcus granulosus CUB 0.003 0.001 0.001
Toxoplasma gondii subtilisin SUB7 0.0334 0.0414 0.8771
Brugia malayi p70 ribosomal S6 kinase beta 0.0039 0.0023 0.0023
Toxoplasma gondii rhoptry neck protein RON9 0.0039 0.0022 0.046
Brugia malayi Probable ATP-dependent helicase DHX35 0.0034 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0039 0.0022 0.0022
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.003 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.012 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0044 0.0028 0.0028
Trypanosoma cruzi arginine N-methyltransferase, type I 0.007 0.0063 0.0737
Plasmodium vivax subtilisin-like protease 1 0.0334 0.0414 0.7946
Plasmodium vivax subtilisin-like protease 2, putative 0.0334 0.0414 0.7946
Loa Loa (eye worm) hypothetical protein 0.0037 0.002 0.002
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0044 0.0028 0.0028
Schistosoma mansoni chromatin regulatory protein sir2 0.0669 0.086 0.086
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0037 0.0019 0.0403
Plasmodium vivax NAD-dependent deacetylase, putative 0.0099 0.0101 0.1942
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0099 0.0101 0.0101
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1511 0.1981 0.3242
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0099 0.0101 0.0101
Echinococcus granulosus Protein kinase C brain isozyme 0.0027 0.0006 0.0006
Plasmodium falciparum plasmepsin III 0.0037 0.0019 0.0365
Loa Loa (eye worm) hypothetical protein 0.0045 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0334 0.0414 0.0678
Brugia malayi Pepsin A precursor 0.0037 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4615 0.611 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0085 0.0083 0.5
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0099 0.0101 0.1178
Loa Loa (eye worm) hypothetical protein 0.0037 0.0019 0.0019
Echinococcus granulosus discoidin domain receptor 0.0051 0.0038 0.0038
Echinococcus granulosus neuropilin nrp and tolloid tll 0.003 0.001 0.001
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0099 0.0101 0.0127
Brugia malayi celfurPC protein 0.6027 0.7989 0.7989
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0025 0.0041
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0038 0.0048
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0051 0.0038 0.0038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0099 0.0101 0.0231
Echinococcus granulosus adam 0.0056 0.0045 0.0045
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.003 0.001 0.001
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.023 0.0276 0.0276
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.007 0.0063 0.0737
Loa Loa (eye worm) protein arginine N-methyltransferase 0.007 0.0063 0.0063
Toxoplasma gondii subtilisin SUB8 0.0334 0.0414 0.8771
Toxoplasma gondii aspartyl protease ASP5 0.0378 0.0472 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0669 0.086 0.086
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0025 0.0041
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0051 0.0038 0.0063
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0101 0.0166
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1845 0.2425 0.3969
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0085 0.0083 0.1595
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1845 0.2425 0.3969
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0038 0.0812
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0334 0.0414 0.0414
Leishmania major UDP-galactopyranose mutase 0.0085 0.0083 0.0547
Onchocerca volvulus 0.0039 0.0022 0.0379
Loa Loa (eye worm) hypothetical protein 0.0195 0.0229 0.0229
Schistosoma mansoni hypothetical protein 0.0096 0.0098 0.0098
Brugia malayi Nematode astacin protease protein 30 0.003 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0334 0.0414 0.0678
Toxoplasma gondii subtilisin SUB12 0.0334 0.0414 0.8771
Schistosoma mansoni hypothetical protein 0.003 0.001 0.001
Plasmodium vivax plasmepsin V, putative 0.0414 0.0521 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Onchocerca volvulus 0.003 0.001 0.0182
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0019 0.0019
Echinococcus multilocularis protein arginine methyltransferase 0.0125 0.0136 0.017
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0085 0.0083 0.1761
Echinococcus multilocularis protein kinase c epsilon type 0.0099 0.0101 0.0127
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0038 0.0812
Echinococcus multilocularis cubilin 0.003 0.001 0.0013
Echinococcus granulosus tissue type plasminogen activator 0.0051 0.0038 0.0038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Brugia malayi hypothetical protein 0.0039 0.0022 0.0022
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0051 0.0038 0.0063
Entamoeba histolytica protein kinase, putative 0.0042 0.0025 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4615 0.611 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0027 0.0027
Brugia malayi Protein kinase domain containing protein 0.0096 0.0098 0.0098
Onchocerca volvulus 0.0037 0.002 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.003 0.001 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0038 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.1511 0.1981 0.3242
Trypanosoma brucei SIR2-like protein 4, putative 0.0099 0.0101 0.0911
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0085 0.0083 0.0083
Schistosoma mansoni memapsin-2 (A01 family) 0.0037 0.0019 0.0019
Echinococcus multilocularis protoporphyrinogen oxidase 0.0085 0.0083 0.0104
Onchocerca volvulus 0.0039 0.0022 0.0379
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0125 0.0136 0.2604
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0669 0.086 1
Trichomonas vaginalis conserved hypothetical protein 0.1511 0.1981 0.3242
Brugia malayi Protein arginine N-methyltransferase 0.007 0.0063 0.0063
Echinococcus granulosus Furin 1 0.1845 0.2425 0.2425
Echinococcus multilocularis neuroendocrine convertase 2 0.4769 0.6315 0.7905
Echinococcus granulosus methyltransferase protein 5 0.007 0.0063 0.0063
Plasmodium falciparum plasmepsin II 0.0037 0.0019 0.0365
Plasmodium vivax LCCL domain-containing protein 0.0051 0.0038 0.0735
Plasmodium falciparum plasmepsin X 0.0037 0.0019 0.0365
Loa Loa (eye worm) hypothetical protein 0.0039 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Giardia lamblia Sirtuin type 2 0.0099 0.0101 0.0231
Loa Loa (eye worm) CUB domain-containing protein 0.003 0.001 0.001
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0038 0.0038
Schistosoma mansoni chromatin regulatory protein sir2 0.0669 0.086 0.086
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4615 0.611 0.611
Leishmania major sir2-family protein-like protein 0.0099 0.0101 0.0768
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Echinococcus granulosus serine:threonine protein kinase N2 0.0072 0.0066 0.0066
Onchocerca volvulus 0.0334 0.0414 0.7217
Brugia malayi zinc metalloproteinase toh-2 precursor 0.003 0.001 0.001
Loa Loa (eye worm) AGC/AKT protein kinase 0.0042 0.0025 0.0025
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0044 0.0028 0.0028
Schistosoma mansoni furin-1 (S08 family) 0.3258 0.4304 0.4304
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0334 0.0414 0.4819
Echinococcus granulosus Tolloid protein 1 0.0044 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0096 0.0098 0.0098
Entamoeba histolytica protein kinase, putative 0.0042 0.0025 0.0294
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0669 0.086 0.1076
Loa Loa (eye worm) lectin C-type domain-containing protein 0.003 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Onchocerca volvulus 0.003 0.001 0.0182
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0019 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0334 0.0414 0.0519
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.005 0.0037 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0006 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0025 0.0041
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0334 0.0414 0.0414
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Brugia malayi hypothetical protein 0.0039 0.0022 0.0022
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0043 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Toxoplasma gondii rhoptry neck protein RON1 0.0039 0.0022 0.046
Plasmodium vivax LCCL domain-containing protein 0.0051 0.0038 0.0735
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0334 0.0414 1
Trichomonas vaginalis conserved hypothetical protein 0.1511 0.1981 0.3242
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0025 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Onchocerca volvulus 0.0039 0.0022 0.0379
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0037 0.0019 0.0019
Echinococcus granulosus cubilin 0.003 0.001 0.001
Toxoplasma gondii AGC kinase 0.0039 0.0023 0.0477
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0019 0.0365
Onchocerca volvulus Putative cubilin 0.0045 0.003 0.0524
Brugia malayi Sushi domain 0.0039 0.0022 0.0022
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0125 0.0136 0.2874
Loa Loa (eye worm) hypothetical protein 0.0039 0.0022 0.0022
Brugia malayi Subtilase family protein 0.0334 0.0414 0.0414
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0099 0.0101 0.1674
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Schistosoma mansoni protein arginine n-methyltransferase 0.007 0.0063 0.0063
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Brugia malayi Kelch motif family protein 0.003 0.001 0.001
Brugia malayi hypothetical protein 0.003 0.001 0.001
Brugia malayi Nematode astacin protease protein 30 0.003 0.001 0.001
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0101 0.0101
Entamoeba histolytica SWIRM domain protein 0.0035 0.0017 0.0199
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0019 0.0019
Schistosoma mansoni amine oxidase 0.0085 0.0083 0.0083
Echinococcus multilocularis c4b binding protein beta chain 0.0039 0.0022 0.0027
Echinococcus multilocularis Tolloid protein 1 0.0044 0.0028 0.0035
Brugia malayi Reprolysin 0.0025 0.0003 0.0003
Brugia malayi CUB domain containing protein 0.003 0.001 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Giardia lamblia Transcriptional regulator, Sir2 family 0.0099 0.0101 0.0231
Echinococcus multilocularis chromatin regulatory protein sir2 0.0669 0.086 0.1076
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0101 0.0101
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0083 0.1595
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.007 0.0063 0.0737
Schistosoma mansoni discoidin domain receptor 0.0051 0.0038 0.0038
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0085 0.0083 0.1595
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0099 0.0101 0.1178
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0037 0.0019 0.0019
Brugia malayi Lectin C-type domain containing protein 0.003 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0019 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0025 0.0041
Entamoeba histolytica hypothetical protein, conserved 0.0099 0.0101 0.1178
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.007 0.0063 0.1342
Toxoplasma gondii histone lysine-specific demethylase 0.0085 0.0083 0.1761
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0017 0.0028
Echinococcus multilocularis MAM 0.0096 0.0098 0.0123
Loa Loa (eye worm) hypothetical protein 0.0096 0.0098 0.0098
Plasmodium falciparum subtilisin-like protease 1 0.0334 0.0414 0.7946
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0037 0.002 0.002
Brugia malayi aspartic protease BmAsp-1, identical 0.0037 0.0019 0.0019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0334 0.0414 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0101 0.0101
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0125 0.0136 0.0222
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Echinococcus granulosus histone arginine methyltransferase CARMER 0.007 0.0063 0.0063
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0669 0.086 0.1407
Trichomonas vaginalis conserved hypothetical protein 0.1511 0.1981 0.3242
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0727 0.0937 0.0937
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0099 0.0101 0.1178
Schistosoma mansoni hypothetical protein 0.003 0.001 0.001
Loa Loa (eye worm) endoprotease bli-4 0.7539 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Loa Loa (eye worm) hypothetical protein 0.0419 0.0527 0.0527
Loa Loa (eye worm) WD40 repeat protein 0.0207 0.0245 0.0245
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0019 0.0365
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0334 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0098 0.0098
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.003 0.001 0.001
Echinococcus granulosus lysine specific histone demethylase 1A 0.0419 0.0527 0.0527
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0019 0.0019
Schistosoma mansoni amine oxidase 0.0085 0.0083 0.0083
Mycobacterium tuberculosis Possible oxidoreductase 0.0085 0.0083 0.1193
Plasmodium vivax apical sushi protein, putative 0.0039 0.0022 0.0417
Onchocerca volvulus 0.0051 0.0038 0.0666
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Brugia malayi CUB domain containing protein 0.003 0.001 0.001
Brugia malayi ADAMTS-like protease 0.0025 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.1511 0.1981 0.3242
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0669 0.086 1
Toxoplasma gondii aspartyl protease ASP1 0.0037 0.0019 0.0403
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0039 0.0022 0.0022
Toxoplasma gondii subtilisin SUB6 0.0334 0.0414 0.8771
Loa Loa (eye worm) hypothetical protein 0.0085 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.1511 0.1981 0.3242
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Echinococcus granulosus growth factor receptor bound protein 2 0.026 0.0316 0.0316
Schistosoma mansoni hypothetical protein 0.0207 0.0245 0.0245
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0051 0.0038 0.0048
Brugia malayi hypothetical protein 0.0039 0.0022 0.0022
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.007 0.0063 0.1342
Schistosoma mansoni hypothetical protein 0.003 0.001 0.001
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0025 0.0041
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0051 0.0038 0.0063
Loa Loa (eye worm) hypothetical protein 0.0034 0.0015 0.0015
Toxoplasma gondii kringle domain-containing protein 0.0051 0.0038 0.0809
Echinococcus granulosus protein kinase c iota type 0.0026 0.0004 0.0004
Schistosoma mansoni dock 0.0051 0.0038 0.0038
Echinococcus granulosus protein kinase c epsilon type 0.0099 0.0101 0.0101
Trypanosoma cruzi arginine N-methyltransferase, type I 0.007 0.0063 0.0737
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0101 0.0101
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0043 0.0027 0.0034
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0334 0.0414 0.0414
Brugia malayi proprotein convertase 2 0.4769 0.6315 0.6315
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0000034698 0.0000043433
Brugia malayi Sex muscle abnormal protein 5 0.026 0.0316 0.0316
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0125 0.0136 0.0222
Echinococcus multilocularis 0.6027 0.7989 1
Trypanosoma cruzi arginine N-methyltransferase, type III 0.007 0.0063 0.0737
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0334 0.0414 0.0678
Onchocerca volvulus 0.0037 0.0019 0.0332
Brugia malayi Protein kinase domain containing protein 0.0051 0.0038 0.0038
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0364 0.0455 0.529
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0334 0.0414 0.0414
Brugia malayi hypothetical protein 0.0037 0.0019 0.0019
Brugia malayi Suppressor of lurcher protein 1 precursor 0.003 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0035 0.0017 0.0199
Echinococcus multilocularis C type lectin domian containing protein 0.0039 0.0022 0.0027
Plasmodium falciparum plasmepsin I 0.0037 0.0019 0.0365
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0419 0.0527 0.066
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0038 0.0063
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.005 0.0037 0.0037
Onchocerca volvulus 0.003 0.001 0.0182
Loa Loa (eye worm) hypothetical protein 0.0025 0.0003 0.0003
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0000034698 0.0000034698
Schistosoma mansoni site-1 peptidase (S08 family) 0.0334 0.0414 0.0414
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0195 0.0229 0.2665
Brugia malayi CUB domain containing protein 0.003 0.001 0.001
Echinococcus multilocularis protein arginine N methyltransferase 7 0.007 0.0063 0.0079
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0334 0.0414 1
Mycobacterium ulcerans NAD-dependent deacetylase 0.0099 0.0101 0.0546
Onchocerca volvulus 0.0039 0.0022 0.0379
Onchocerca volvulus 0.0039 0.0022 0.0379
Treponema pallidum 76K protein 0.0023 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0022 0.0022
Brugia malayi Will die slowly protein 0.0207 0.0245 0.0245
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0125 0.0136 0.0136
Plasmodium falciparum protoporphyrinogen oxidase 0.0085 0.0083 0.1595
Mycobacterium ulcerans Sir2-like regulatory protein 0.0099 0.0101 0.0546
Loa Loa (eye worm) TK/ROR protein kinase 0.0051 0.0038 0.0038
Brugia malayi GCC2 and GCC3 family protein 0.0054 0.0041 0.0041
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0099 0.0101 0.0127
Echinococcus multilocularis membrane bound transcription factor site 1 0.0334 0.0414 0.0519
Schistosoma mansoni c4b-binding protein beta chain 0.0039 0.0022 0.0022
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0043 0.0027 0.0027
Loa Loa (eye worm) TK/EGFR protein kinase 0.0727 0.0937 0.0937
Trichomonas vaginalis WD repeat domain, putative 0.0207 0.0245 0.0401
Schistosoma mansoni btb and poz domain-containing protein 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0334 0.0414 0.0414
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0125 0.0136 0.0222
Echinococcus granulosus protein arginine N methyltransferase 8 0.0125 0.0136 0.0136
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0669 0.086 0.086
Plasmodium falciparum plasmepsin IV 0.0037 0.0019 0.0365
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0099 0.0101 0.1942
Echinococcus multilocularis protein will die slowly 0.0207 0.0245 0.0307
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0101 0.0166
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0000034698 0.0000034698
Echinococcus multilocularis Furin 1 0.1845 0.2425 0.3036
Entamoeba histolytica PH domain containing protein kinase, putative 0.0074 0.0068 0.0796
Brugia malayi transcriptional regulator, Sir2 family protein 0.0099 0.0101 0.0101
Brugia malayi pregnancy-associated plasma protein-A 0.0039 0.0022 0.0022
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4615 0.611 0.7648
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0043 0.0027 0.0027
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0195 0.0229 0.2443
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0019 0.0019
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.7539 1 1
Brugia malayi aspartic protease BmAsp-2, identical 0.0037 0.0019 0.0019
Trypanosoma cruzi subtilisin peptidase 0.0334 0.0414 0.4819
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0101 0.0166
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0038 0.0038
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0019 0.0019
Mycobacterium tuberculosis Conserved hypothetical protein 0.0085 0.0083 0.1193
Brugia malayi transcriptional regulator, Sir2 family protein 0.0099 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0037 0.002 0.002
Leishmania major subtilisin-like serine peptidase 0.0334 0.0414 0.4578
Entamoeba histolytica protein kinase, putative 0.0039 0.0023 0.0262
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0099 0.0101 0.0911
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0038 0.0038
Loa Loa (eye worm) transcriptional regulator 0.0099 0.0101 0.0101
Leishmania major arginine N-methyltransferase, type I 0.007 0.0063 0.0306
Echinococcus multilocularis growth factor receptor bound protein 2 0.026 0.0316 0.0396
Echinococcus granulosus c4b binding protein beta chain 0.0039 0.0022 0.0022
Brugia malayi hypothetical protein 0.0195 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.2924 0.386 0.386
Schistosoma mansoni septate junction protein 0.0066 0.0058 0.0058
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.003 0.001 0.0013
Toxoplasma gondii aspartyl protease ASP3 0.0037 0.0019 0.0403
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0419 0.0527 0.0527
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0085 0.0083 0.1595
Brugia malayi Protein kinase domain containing protein 0.0051 0.0038 0.0038

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) uM Inhibition of secretion of radiolabeled serotonin from washed human platelets stimulated by 1 nM thrombin; nd means not determined ChEMBL. 11814787
IC50 (binding) uM Displacement of [3H]-SFFLRR-NH2 from human thrombin receptor PAR-1 ChEMBL. 11814787
IC50 (functional) 0 uM Inhibition of secretion of radiolabeled serotonin from washed human platelets stimulated by 1 nM thrombin; nd means not determined ChEMBL. 11814787
IC50 (binding) 0 uM Displacement of [3H]-SFFLRR-NH2 from human thrombin receptor PAR-1 ChEMBL. 11814787
IC50 (functional) = 2.99 uM Antagonistic activity against thrombin receptor, inhibition of secreted radiolabeled [3H]-5-HT from washed human platelets stimulated by 3 microM thrombin receptor activating peptide (TRAP) ChEMBL. 11814787
IC50 (functional) = 2.99 uM Antagonistic activity against thrombin receptor, inhibition of secreted radiolabeled [3H]-5-HT from washed human platelets stimulated by 3 microM thrombin receptor activating peptide (TRAP) ChEMBL. 11814787

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.