Detailed information for compound 1845875

Basic information

Technical information
  • TDR Targets ID: 1845875
  • Name: ethyl 2-[(5Z)-2,4-dioxo-5-[[4-(trifluoromethy l)phenyl]methylidene]-1,3-thiazolidin-3-yl]ac etate
  • MW: 359.32 | Formula: C15H12F3NO4S
  • H donors: 0 H acceptors: 3 LogP: 3.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CN1C(=O)S/C(=C\c2ccc(cc2)C(F)(F)F)/C1=O
  • InChi: 1S/C15H12F3NO4S/c1-2-23-12(20)8-19-13(21)11(24-14(19)22)7-9-3-5-10(6-4-9)15(16,17)18/h3-7H,2,8H2,1H3/b11-7-
  • InChiKey: VNTWFZGOMRJLBF-XFFZJAGNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[(5Z)-2,4-dioxo-5-[[4-(trifluoromethyl)phenyl]methylene]thiazolidin-3-yl]acetate
  • 2-[(5Z)-2,4-dioxo-5-[[4-(trifluoromethyl)phenyl]methylene]-3-thiazolidinyl]acetic acid ethyl ester
  • 2-[(5Z)-2,4-diketo-5-[4-(trifluoromethyl)benzylidene]thiazolidin-3-yl]acetic acid ethyl ester
  • ethyl 2-[(5Z)-2,4-dioxo-5-[[4-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidin-3-yl]ethanoate
  • ZINC01138128
  • STK056420

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peroxisome proliferator-activated receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus ecdysone induced protein 78C peroxisome proliferator-activated receptor gamma 477 aa 447 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0098 0.012
Leishmania major DNA polymerase eta, putative 0.0079 0.0858 0.2343
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1224 0.1733
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0142 0.1241
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.003
Brugia malayi jmjC domain containing protein 0.0025 0.0188 0.0328
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.003
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0112 0.0977
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.1056 0.1056
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0019 0.0034
Schistosoma mansoni DNA polymerase eta 0.0079 0.0858 0.101
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0236 0.0278
Leishmania major hypothetical protein, conserved 0.0017 0.0087 0.0227
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0622 0.1705
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0015 0.0017
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0112 0.0317
Echinococcus granulosus dnaJ subfamily B 0.0414 0.4983 0.5868
Onchocerca volvulus 0.0012 0.0019 0.0068
Echinococcus granulosus Chromobox protein 3 0.0012 0.0019 0.0023
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0039 0.0358 0.0358
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3526 0.5512
Brugia malayi polk-prov protein 0.0044 0.0415 0.0726
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0169 0.0264
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0113 0.032
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0017 0.0083 0.0723
Giardia lamblia Sgs1 DNA helicase, putative 0.0039 0.0358 0.1016
Schistosoma mansoni intermediate filament proteins 0.0054 0.0543 0.0639
Trichomonas vaginalis DNA polymerase eta, putative 0.0081 0.0872 0.1363
Plasmodium vivax DNA repair protein REV1, putative 0.0017 0.0083 0.0723
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0094 0.1041 0.2855
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0416 0.1142
Schistosoma mansoni hypothetical protein 0.0036 0.0326 0.0384
Plasmodium falciparum adrenodoxin-type ferredoxin, putative 0.0017 0.0087 0.0757
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0327 0.0447
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0083 0.0227
Schistosoma mansoni blooms syndrome DNA helicase 0.0046 0.0445 0.0524
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0327 0.0511
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0692 0.1211
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0142 0.0389
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0074 0.0204
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0258 0.0303
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0188 0.0221
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0327 0.0447
Schistosoma mansoni gliotactin 0.0011 0.0015 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0173 0.0248
Trypanosoma brucei unspecified product 0.0037 0.0334 0.0916
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.1056 0.2889
Loa Loa (eye worm) hypothetical protein 0.0039 0.0365 0.0638
Giardia lamblia [2Fe-2S] ferredoxin 0.0017 0.0087 0.0246
Loa Loa (eye worm) hypothetical protein 0.0473 0.5714 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0112 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0258 0.0303
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0011 0.0015 0.0023
Plasmodium vivax importin-beta 2, putative 0.0029 0.0237 0.2071
Brugia malayi Adrenodoxin-like protein, mitochondrial precursor, putative 0.0017 0.0087 0.0152
Brugia malayi glucose-6-phosphate dehydrogenase 0.0094 0.1041 0.1822
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.004 0.0047
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0082 0.0713
Echinococcus multilocularis musashi 0.0054 0.0543 0.0543
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0173 0.0227
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0327 0.0895
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0236 0.0412
Onchocerca volvulus 0.0011 0.0015 0.0052
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0083 0.0227
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0169 0.0264
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1056 0.1651
Brugia malayi PHD-finger family protein 0.0029 0.0233 0.0407
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3526 0.5512
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0407 0.1117
Echinococcus multilocularis epidermal growth factor receptor 0.0244 0.2893 0.2893
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1056 0.1651
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0078 0.0136
Schistosoma mansoni terminal deoxycytidyl transferase 0.0054 0.054 0.0635
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0019 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1056 0.1244
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0019 0.0113 0.0987
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.003 0.0252 0.069
Onchocerca volvulus 0.0012 0.0019 0.0068
Echinococcus granulosus intermediate filament protein 0.0054 0.0543 0.0639
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.00000034704 0.00000098432
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.00000034704 0.00000040868
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0083 0.0227
Loa Loa (eye worm) hypothetical protein 0.0036 0.0327 0.0572
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0082 0.0117
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2483 0.4346
Trichomonas vaginalis chromobox protein, putative 0.007 0.0747 0.1168
Chlamydia trachomatis ferredoxin 0.0017 0.0087 0.0832
Echinococcus multilocularis lamin 0.0054 0.0543 0.0543
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0622 0.0871
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0094 0.1041 0.1041
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0188 0.1639
Echinococcus multilocularis Smad4 0.0016 0.0078 0.0078
Treponema pallidum NADH oxidase 0.0017 0.0082 0.0232
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0086 0.0102
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0154 0.1776 0.1776
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0019 0.017
Echinococcus multilocularis Chromo domain 0.0012 0.0019 0.0019
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0015 0.0017
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.2749 0.392
Brugia malayi Bromodomain containing protein 0.0029 0.0233 0.0407
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0142 0.0249
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0233 0.0233
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.1056 0.1849
Brugia malayi Protein cec-1. 0.0012 0.0019 0.0034
Echinococcus granulosus lamin dm0 0.0054 0.0543 0.0639
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0062 0.0637 0.0912
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0017 0.0087 0.0832
Echinococcus granulosus Smad4 0.0016 0.0078 0.0092
Schistosoma mansoni Smad4 0.0016 0.0078 0.0092
Schistosoma mansoni hypothetical protein 0.0339 0.406 0.4781
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.003
Trypanosoma cruzi adrenodoxin precursor, putative 0.0017 0.0087 0.0238
Schistosoma mansoni ran 0.0021 0.0142 0.0167
Entamoeba histolytica hypothetical protein 0.0036 0.0326 0.0925
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0467 0.1281
Loa Loa (eye worm) helicase 0.0012 0.0019 0.0034
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.0055
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0188 0.0328
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0074 0.013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0237 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0872 0.239
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0872 0.239
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0094 0.1041 0.2855
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0258 0.0303
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0041 0.0386 0.3371
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0074 0.0649
Loa Loa (eye worm) hypothetical protein 0.0065 0.0683 0.1195
Mycobacterium leprae Probable lipase LipE 0.0036 0.0327 0.0467
Echinococcus granulosus importin subunit beta 1 0.0029 0.0237 0.0279
Schistosoma mansoni ap endonuclease 0.0019 0.0112 0.0132
Loa Loa (eye worm) hypothetical protein 0.0031 0.0259 0.0454
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0039 0.0358 0.0422
Giardia lamblia PHD finger protein 15 0.0029 0.0233 0.066
Giardia lamblia DINP protein human, muc B family 0.006 0.0622 0.1764
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0284 0.077
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0543 0.095
Onchocerca volvulus 0.0096 0.1068 0.3757
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.004 0.0047
Loa Loa (eye worm) hypothetical protein 0.0066 0.0692 0.1211
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0103 0.1145 1
Brugia malayi hypothetical protein 0.0124 0.1406 0.2461
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0142 0.1241
Treponema pallidum fructose-bisphosphate aldolase 0.0295 0.3526 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0224
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0156 0.1809 0.2589
Leishmania major DNA polymerase kappa, putative 0.0017 0.0083 0.0216
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0327 0.0895
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.1062 0.1251
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.3526 1
Echinococcus granulosus epidermal growth factor receptor 0.0244 0.2893 0.3407
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0054 0.054 0.0635
Echinococcus granulosus peregrin 0.0029 0.0233 0.0274
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0082 0.0224
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0074 0.0649
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0142 0.1241
Leishmania major DNA polymerase kappa, putative 0.006 0.0622 0.1696
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0015 0.0133
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0249 0.2951 0.4222
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0402 0.1413
Schistosoma mansoni hypothetical protein 0.0029 0.0233 0.0274
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0327 0.0447
Brugia malayi beta-lactamase family protein 0.0036 0.0327 0.0572
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0082 0.0784
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0692 0.0815
Brugia malayi glutathione reductase 0.0048 0.0467 0.0818
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0019 0.017
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0467 0.0818
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1661 0.4549
Entamoeba histolytica recQ family helicase, putative 0.0045 0.0427 0.1211
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0172
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0284 0.2483
Mycobacterium ulcerans carboxylesterase, LipT 0.0011 0.0015 0.0021
Onchocerca volvulus 0.0011 0.0012 0.0043
Loa Loa (eye worm) 2Fe-2S iron-sulfur cluster binding domain-containing protein 0.0017 0.0087 0.0152
Loa Loa (eye worm) hypothetical protein 0.0124 0.1406 0.2461
Leishmania major adrenodoxin-like protein,ferredoxin, 2fe-2s-like protein 0.0017 0.0087 0.0227
Schistosoma mansoni hypothetical protein 0.0012 0.0019 0.0023
Brugia malayi MH1 domain containing protein 0.0016 0.0078 0.0136
Brugia malayi beta-lactamase 0.0036 0.0327 0.0572
Leishmania major ferredoxin, 2fe-2s-like protein 0.0017 0.0087 0.0227
Loa Loa (eye worm) hypothetical protein 0.0036 0.0327 0.0572
Plasmodium falciparum DNA repair protein REV1, putative 0.0017 0.0083 0.0723
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0407 0.1117
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0327 0.2852
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0327 0.0467
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0082 0.7298
Schistosoma mansoni hypothetical protein 0.0084 0.0911 0.1073
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0112 0.0307
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0258 0.225
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0467 0.0649
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0094 0.1041 0.1822
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0169 0.0264
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0101 0.0157
Echinococcus multilocularis snurportin 1 0.0311 0.372 0.372
Echinococcus multilocularis Adrenodoxin, mitochondrial 0.0017 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0034
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.003
Schistosoma mansoni jumonji domain containing protein 0.0134 0.1537 0.181
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0081 0.0872 0.1363
Brugia malayi Carboxylesterase family protein 0.0011 0.0015 0.0026
Plasmodium vivax SET domain protein, putative 0.0031 0.0258 0.225
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0365 0.057
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0082 0.0713
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0294 0.0515
Mycobacterium ulcerans oxygenase 0.0017 0.0087 0.0124
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0034
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0082 0.0213
Schistosoma mansoni hypothetical protein 0.0096 0.1068 0.1257
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0872 0.239
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0039 0.0358 0.0627
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0142 0.0389
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0084 0.0911 0.0911
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0103 0.1145 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0054 0.054 0.0635
Mycobacterium tuberculosis Conserved protein 0.0036 0.0327 0.0447
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0142 0.0403
Treponema pallidum ATP-dependent DNA helicase 0.002 0.0122 0.0347
Loa Loa (eye worm) hypothetical protein 0.0039 0.0358 0.0627
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0284 0.0806
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.3647 1
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0004 0.0034
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0094 0.1041 0.2847
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0078 0.0092
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0094 0.1041 0.149
Trichomonas vaginalis Ferredoxin 6 0.0017 0.0087 0.0136
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0233 0.0274
Toxoplasma gondii adrenodoxin-type ferredoxin, putative 0.0017 0.0087 0.0757
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0214
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0427 0.117
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0082 0.0224
Trichomonas vaginalis rotamase, putative 0.0033 0.0284 0.0444
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0858 0.2351
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0377 0.329
Trichomonas vaginalis DNA helicase recq1, putative 0.0066 0.0691 0.108
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0017 0.0087 0.0103
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0401 0.35
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0872 0.239
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0224
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1374 0.1949
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0026
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0015 0.0017
Plasmodium vivax glutathione reductase, putative 0.0048 0.0467 0.4082
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0019 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0063 0.0099
Loa Loa (eye worm) hypothetical protein 0.0025 0.0186 0.0326
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0112 1
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0202 0.0573
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0039 0.0358 0.0422
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.00000034704 0.00000054258
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1056 0.2896
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0461 0.072
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0188 0.0221
Brugia malayi Protein kinase domain containing protein 0.0145 0.1671 0.2924
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0173 0.0248
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0365 0.057
Schistosoma mansoni adrenodoxin 0.0017 0.0087 0.0102
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0019 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3526 0.5512
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.003
Echinococcus multilocularis lamin dm0 0.0054 0.0543 0.0543
Leishmania major adrenodoxin-like protein,ferredoxin, 2fe-2s-like protein 0.0017 0.0087 0.0227
Echinococcus multilocularis peregrin 0.0029 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0026
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0326 0.0384
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0172
Wolbachia endosymbiont of Brugia malayi ferredoxin 0.0017 0.0087 0.7747
Entamoeba histolytica hypothetical protein 0.0024 0.0169 0.0479
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0112 0.0307
Brugia malayi Heterochromatin protein 1 0.007 0.0747 0.1307
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0112 0.0307
Echinococcus granulosus chromobox protein 1 0.007 0.0747 0.0879
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0094 0.1041 0.1226
Schistosoma mansoni hypothetical protein 0.0291 0.3474 0.4091
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0303
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.1068 0.1868
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0872 0.239
Toxoplasma gondii ABC1 family protein 0.0036 0.0327 0.2852
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0026
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0101 0.1122 0.1605
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.057 0.4979
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0202 0.0554
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0082 0.0713
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.1056 0.3717
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0087 0.0238
Echinococcus granulosus bloom syndrome protein 0.0066 0.0691 0.0813
Trypanosoma brucei DNA polymerase eta, putative 0.0079 0.0858 0.2351
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0117 0.0204
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0074 0.0074
Brugia malayi jmjC domain containing protein 0.0096 0.1062 0.1859
Onchocerca volvulus 0.0054 0.0543 0.191
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0188 0.0221
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1374 0.1949
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0083 0.0227
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0327 0.0895
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0083 0.0227
Brugia malayi beta-lactamase family protein 0.0036 0.0327 0.0572
Mycobacterium ulcerans hypothetical protein 0.0024 0.0173 0.0248
Loa Loa (eye worm) apoptosis regulator protein 0.0084 0.0911 0.1594
Loa Loa (eye worm) hypothetical protein 0.0124 0.1406 0.2461
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0233 0.2033
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.0872 0.239
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0188 0.0515
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0074 0.0204
Trypanosoma brucei electron transfer protein, putative 0.0017 0.0087 0.0238
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0074 0.0074
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0327 0.0511
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0327 0.0511
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0237 0.065
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0019 0.017
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.4983 0.4983
Brugia malayi jmjC domain containing protein 0.0025 0.0188 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0294 0.046
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.0872 0.1247
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0872 0.239
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0017 0.0087 0.0124
Leishmania major DNA polymerase eta, putative 0.0042 0.0401 0.1089
Echinococcus multilocularis chromobox protein 2 0.0012 0.0019 0.0019
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0112 0.0112
Echinococcus granulosus ferredoxin 0.0017 0.0087 0.0102
Brugia malayi PHD-finger family protein 0.0011 0.0014 0.0024
Brugia malayi Carboxylesterase family protein 0.0011 0.0015 0.0026
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0233 0.0407
Echinococcus multilocularis replication factor c subunit 1 0.001 0.00000034704 0.00000034704
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0202 0.0316
Brugia malayi Bloom's syndrome protein homolog 0.0066 0.0691 0.1209
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0222 0.0348
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0112 0.016
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0327 0.0385
Echinococcus granulosus smad 0.0016 0.0078 0.0092
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0074 0.0088
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0188 0.0328
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0084 0.0911 0.1594
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0026
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0019 0.0023
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0173 0.0248
Echinococcus granulosus Adrenodoxin mitochondrial 0.0017 0.0087 0.0102
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1659 0.2359
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0692 0.0692
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0112 0.0175
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0017 0.0087 0.0103
Treponema pallidum hypothetical protein 0.0071 0.075 0.2127
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0062 0.0637 0.5567
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0358 0.3129
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0872 0.239
Brugia malayi Pre-SET motif family protein 0.0031 0.0258 0.0451
Schistosoma mansoni hypothetical protein 0.0414 0.4983 0.5868
Onchocerca volvulus 0.0029 0.0236 0.0829
Onchocerca volvulus 0.0036 0.0327 0.1149
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0019 0.0034
Loa Loa (eye worm) hypothetical protein 0.0084 0.0911 0.1594
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1056 0.1651
Loa Loa (eye worm) hypothetical protein 0.0183 0.2131 0.3729
Onchocerca volvulus Alhambra homolog 0.0029 0.0233 0.0819
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0651 0.0767
Trichomonas vaginalis Ferredoxin 3 0.0017 0.0087 0.0136
Onchocerca volvulus Huntingtin homolog 0.0124 0.1406 0.4949
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.1056 0.1244
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0416 0.1142
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0027 0.0048
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0015 0.0017
Plasmodium falciparum flap endonuclease 1 0.0026 0.0202 0.1766
Schistosoma mansoni tyrosine kinase 0.0244 0.2893 0.3407
Trypanosoma cruzi adrenodoxin precursor, putative 0.0017 0.0087 0.0238
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0244 0.2893 0.3407
Echinococcus multilocularis dna polymerase kappa 0.0081 0.0872 0.0872
Entamoeba histolytica hypothetical protein 0.0036 0.0326 0.0925
Echinococcus multilocularis smad 0.0016 0.0078 0.0078
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0082 0.0713
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0098 0.0858
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0004 0.0011
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0103 0.1145 0.179
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0117
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0198 0.0234
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0142 0.0142
Mycobacterium tuberculosis Probable oxidoreductase 0.0017 0.0087 0.0103
Trichomonas vaginalis set domain proteins, putative 0.024 0.2842 0.4443
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0019 0.0023
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0096
Treponema pallidum hypothetical protein 0.0086 0.0937 0.2657
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0188 0.1639
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0258 0.0258
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0083 0.0227
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1056 0.2896
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0082 0.0096
Schistosoma mansoni acetylcholinesterase 0.0011 0.0015 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0086 0.0102
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0096 0.0113
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.0872 0.1247
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0872 0.239
Brugia malayi N-terminal motif family protein 0.0183 0.2131 0.3729
Echinococcus granulosus phd:f box containing protein 0.0025 0.0188 0.0221
Plasmodium falciparum thioredoxin reductase 0.0048 0.0467 0.4082
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0172
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0098 0.0944
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0082 0.0232
Trypanosoma brucei trypanothione reductase 0.0048 0.0467 0.1281
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0084 0.0911 0.1073
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0173 0.0464
Trichomonas vaginalis rotamase, putative 0.0034 0.0294 0.046
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0074 0.0204
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0169 0.0463
Echinococcus granulosus acetylcholinesterase 0.0066 0.0692 0.0815
Echinococcus granulosus insulin receptor 0.0145 0.1671 0.1968
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0173 0.0248
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0015 0.0017
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0402 0.0628
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0173 0.0248
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0082 0.0213
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0528 0.6396 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0039 0.0358 0.0358
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0039 0.0358 0.3129
Loa Loa (eye worm) hypothetical protein 0.0031 0.0258 0.0451
Echinococcus granulosus survival motor neuron protein 1 0.0473 0.5714 0.6729
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0019 0.0034
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.2824 0.4942
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0074 0.0649
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0112 0.0196
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0188 0.0328
Plasmodium falciparum glutathione reductase 0.0017 0.0082 0.0713
Echinococcus granulosus flap endonuclease 1 0.0026 0.0202 0.0238
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1056 0.1651
Schistosoma mansoni importin beta-1 0.0029 0.0237 0.0279
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0233 0.2033
Leishmania major hypothetical protein, conserved 0.0036 0.0327 0.0886
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0365 0.1283
Brugia malayi isocitrate dehydrogenase 0.0016 0.0074 0.013
Schistosoma mansoni cpg binding protein 0.0029 0.0236 0.0277
Trichomonas vaginalis Ferredoxin 7 0.0017 0.0087 0.0136
Echinococcus multilocularis 0.0141 0.1615 0.1615
Brugia malayi ImpB/MucB/SamB family protein 0.0079 0.0858 0.1501
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0327 0.0447
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0015 0.0017
Brugia malayi Importin beta-1 subunit 0.0029 0.0237 0.0415
Loa Loa (eye worm) TK/INSR protein kinase 0.0145 0.1671 0.2924
Loa Loa (eye worm) carboxylesterase 0.0011 0.0015 0.0026
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0112 0.0196
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0327 0.0447
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0078 0.0136
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0401 0.1099
Schistosoma mansoni chromobox protein 0.007 0.0747 0.0879
Trichomonas vaginalis esterase, putative 0.0036 0.0327 0.0511
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0173 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0222 0.0348
Brugia malayi CXXC zinc finger family protein 0.0029 0.0236 0.0412
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.0055
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0173 0.0464
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0188 0.0221
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0173 0.0464
Echinococcus multilocularis cpg binding protein 0.0031 0.0256 0.0256
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1659 0.2375
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0019 0.017
Schistosoma mansoni tyrosine kinase 0.0242 0.2861 0.337
Schistosoma mansoni microtubule-associated protein tau 0.0698 0.8492 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0858 0.1501
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.3647 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0101 0.0157
Mycobacterium tuberculosis Conserved hypothetical protein 0.0054 0.054 0.0753
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0074 0.0074
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0427 0.0667
Echinococcus granulosus acetylcholinesterase 0.0066 0.0692 0.0815
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0523 0.1434
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.3526 1
Echinococcus granulosus X box binding protein 1 0.0291 0.3474 0.4091
Schistosoma mansoni lamin 0.0054 0.0543 0.0639
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.035 0.4195 0.6003
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0467 0.0467
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.1224 0.1751
Brugia malayi Pre-SET motif family protein 0.0211 0.2483 0.4346
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0233 0.0274
Echinococcus granulosus geminin 0.0339 0.406 0.4781
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0084 0.0911 0.1073
Entamoeba histolytica recQ family DNA helicase 0.002 0.0122 0.0347
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0083 0.0227
Brugia malayi jmjC domain containing protein 0.0025 0.0188 0.0328
Loa Loa (eye worm) hypothetical protein 0.0036 0.0327 0.0572
Schistosoma mansoni tyrosine kinase 0.0242 0.2861 0.337
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0327 0.0467
Onchocerca volvulus Huntingtin homolog 0.0124 0.1406 0.4949
Loa Loa (eye worm) glutathione reductase 0.0048 0.0467 0.0818
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0415 0.1137
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0031 0.0263 0.0721
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0188 0.0188
Brugia malayi MH2 domain containing protein 0.0016 0.0078 0.0136
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0122 0.0335
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0015 0.0017
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0112 0.0317
Loa Loa (eye worm) hypothetical protein 0.0036 0.0327 0.0572
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.00000034704 0.00000054258
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0358 0.3129
Schistosoma mansoni chromobox protein 0.0012 0.0019 0.0023
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0142 0.0249
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0576 0.6988 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0202 0.0544
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0237 0.2071
Brugia malayi Carboxylesterase family protein 0.0066 0.0692 0.1211
Schistosoma mansoni chromobox protein 0.0012 0.0019 0.0023
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0576 0.6988 1
Plasmodium vivax ferredoxin, putative 0.0017 0.0087 0.0757
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.1062 0.1859
Loa Loa (eye worm) hypothetical protein 0.0036 0.0327 0.0572
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0103 0.1145 0.3247
Echinococcus granulosus jumonji domain containing protein 0.004 0.0372 0.0438
Schistosoma mansoni tyrosine kinase 0.0242 0.2861 0.337
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0101 0.0157
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0074 0.0088
Schistosoma mansoni ap endonuclease 0.0019 0.0112 0.0132
Echinococcus granulosus cpg binding protein 0.0031 0.0256 0.0302
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0202 0.0554
Trichomonas vaginalis Ferredoxin 4 0.0017 0.0087 0.0136
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.3647 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0258 0.0258
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0082 0.0117
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0284 0.0779
Leishmania major DNA damage repair protein, putative 0.0017 0.0083 0.0216
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0026
Entamoeba histolytica hypothetical protein 0.0012 0.0019 0.0055
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0074 0.0074
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0082 0.0224
Schistosoma mansoni cpg binding protein 0.0031 0.0256 0.0302
Schistosoma mansoni ran 0.0021 0.0142 0.0167
Giardia lamblia DNA damage repair protein 0.0017 0.0083 0.0235
Plasmodium falciparum importin beta, putative 0.0029 0.0237 0.2071
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.372 0.651
Trichomonas vaginalis ran, putative 0.0021 0.0142 0.0222
Loa Loa (eye worm) hypothetical protein 0.0054 0.0543 0.095
Entamoeba histolytica hypothetical protein 0.0036 0.0326 0.0925
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0078 0.0092
Schistosoma mansoni smad1 5 8 and 0.0016 0.0078 0.0092
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0249 0.2951 0.421
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0078 0.0078
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0145 0.1671 0.1968
Echinococcus multilocularis expressed protein 0.0034 0.0294 0.0294
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0234 0.0409
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0094 0.1041 0.2953
Mycobacterium ulcerans beta-lactamase 0.0036 0.0327 0.0467
Trypanosoma brucei unspecified product 0.0074 0.0789 0.2164
Schistosoma mansoni DNA helicase recq1 0.0039 0.0358 0.0422
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0198 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0872 0.239
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0034
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0027 0.0048
Loa Loa (eye worm) hypothetical protein 0.0066 0.0692 0.1211
Toxoplasma gondii ferredoxin, putative 0.0017 0.0087 0.0757
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1056 0.1651
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0112 0.0317
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0173 0.0303
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0026
Echinococcus granulosus dna polymerase eta 0.0079 0.0858 0.101
Loa Loa (eye worm) hypothetical protein 0.0025 0.0186 0.0326
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0078 0.0078
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0188 0.0221
Schistosoma mansoni tyrosine kinase 0.0455 0.5491 0.6466
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0224
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0213
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0063 0.0099
Trichomonas vaginalis Ferredoxin 1 0.0017 0.0087 0.0136
Entamoeba histolytica hypothetical protein 0.0012 0.0019 0.0055
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0327 0.0447
Loa Loa (eye worm) hypothetical protein 0.0025 0.0188 0.0328
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0019 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0173 0.0248
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1056 0.1651
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0101 0.0157
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0224
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.001 0.0004 0.0347
Schistosoma mansoni hypothetical protein 0.0311 0.372 0.4381
Toxoplasma gondii ferodoxin FD 0.0017 0.0087 0.0757
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0183 0.2131 0.7497
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.003
Toxoplasma gondii hypothetical protein 0.0049 0.0485 0.4238
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0467 0.055
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0172
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0086 0.0102
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0692 0.0692
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0692 0.0692
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0872 0.239
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0461 0.072
Echinococcus multilocularis lysine specific demethylase 5A 0.0094 0.1042 0.1042
Schistosoma mansoni flap endonuclease-1 0.0024 0.0171 0.0201
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.0872 0.239
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0096
Onchocerca volvulus 0.0054 0.0543 0.191
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0098 0.0141
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0112 0.0977
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1374 0.1966
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0082 0.0128
Loa Loa (eye worm) hypothetical protein 0.015 0.1724 0.3017
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0074 0.0074
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0084 0.0911 0.1073
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0415 0.1137
Brugia malayi 2Fe-2S iron-sulfur cluster binding domain containing protein 0.0017 0.0087 0.0152
Schistosoma mansoni smad1 5 8 and 0.0016 0.0078 0.0092
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0101 0.0157
Brugia malayi SET domain containing protein 0.0013 0.0041 0.0072
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.1062 0.1251
Mycobacterium ulcerans electron transfer protein FdxB 0.0017 0.0087 0.0124
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0402 0.0628
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0103 0.1145 0.179
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0173 0.0303
Echinococcus multilocularis geminin 0.0339 0.406 0.406
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1661 0.4555
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0019 0.003
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0427 0.117
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0178 0.2078 0.2974
Brugia malayi hypothetical protein 0.0011 0.0015 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1863 0.265
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0074 0.0085
Trypanosoma brucei unspecified product 0.0037 0.0334 0.0916
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0019 0.017
Entamoeba histolytica deoxycytidyl transferase, putative 0.0054 0.054 0.1531
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0358 0.0627
Echinococcus multilocularis survival motor neuron protein 1 0.0473 0.5714 0.5714
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0258 0.0303
Treponema pallidum quinoline 2-oxidoreductase 0.0084 0.0912 0.2587
Giardia lamblia Kinase, PLK 0.0095 0.1056 0.2996
Echinococcus multilocularis insulin receptor 0.0145 0.1671 0.1671
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0224
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0427 0.1161
Brugia malayi Smad1 0.0016 0.0078 0.0136
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0611 0.107
Echinococcus granulosus replication factor c subunit 1 0.001 0.00000034704 0.00000040868
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0103 0.1145 1
Onchocerca volvulus 0.0042 0.04 0.1407
Loa Loa (eye worm) hypothetical protein 0.0036 0.0327 0.0572
Echinococcus granulosus dna polymerase kappa 0.0081 0.0872 0.1026
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0103 0.1145 0.179
Trypanosoma cruzi adrenodoxin precursor, putative 0.0017 0.0087 0.0238
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3526 0.5512
Schistosoma mansoni tyrosine kinase 0.0145 0.1671 0.1968
Schistosoma mansoni adrenodoxin 0.0017 0.0087 0.0102
Schistosoma mansoni tyrosine kinase 0.0244 0.2893 0.3407
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.1056 0.2996
Trichomonas vaginalis hypothetical protein 0.0012 0.0019 0.003
Onchocerca volvulus 0.024 0.2842 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0142 0.0403
Schistosoma mansoni apoptosis regulator bax 0.0084 0.0911 0.1073
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0173 0.0248
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0026
Schistosoma mansoni hypothetical protein 0.0084 0.0911 0.1073
Plasmodium vivax JmjC domain containing protein 0.0025 0.0188 0.1639
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0326 0.0326
Leishmania major hypothetical protein, conserved 0.0025 0.0188 0.0504
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0082
Schistosoma mansoni rotamase 0.0034 0.0294 0.0346
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0034
Onchocerca volvulus 0.0036 0.0327 0.1149
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0188 0.0188
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0407 0.1117
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0094 0.1041 0.1226
Brugia malayi hypothetical protein 0.0012 0.0019 0.0034
Mycobacterium ulcerans oxidoreductase 0.0017 0.0087 0.0124
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0029 0.0233 0.0407
Onchocerca volvulus 0.0011 0.0015 0.0052
Schistosoma mansoni lamin 0.0054 0.0543 0.0639
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0576 0.6988 1
Brugia malayi jmjC domain containing protein 0.0154 0.1776 0.3109
Onchocerca volvulus 0.0031 0.0259 0.0912
Schistosoma mansoni cpg binding protein 0.0031 0.0256 0.0302
Toxoplasma gondii exonuclease III APE 0.0019 0.0112 0.0977
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0327 0.0511
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.003
Brugia malayi hypothetical protein 0.0036 0.0326 0.0571
Loa Loa (eye worm) RecQ helicase 0.0066 0.0691 0.1209
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0017 0.0087 0.0124
Trypanosoma brucei chrX additional, unordered contigs 0.0017 0.0083 0.0227
Brugia malayi hypothetical protein 0.0473 0.5714 1
Onchocerca volvulus 0.0017 0.0087 0.0305
Trypanosoma brucei polo-like protein kinase 0.0095 0.1056 0.2896
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0015 0.0015
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0019 0.0019
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0188 0.0221
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0004 0.0011
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0082 0.0713
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0173 0.0248
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0188 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.003
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.0055
Schistosoma mansoni smad1 5 8 and 0.0016 0.0078 0.0092
Mycobacterium ulcerans oxidoreductase 0.0017 0.0087 0.0124
Trichomonas vaginalis DNA helicase recq, putative 0.0066 0.0691 0.108
Plasmodium falciparum thioredoxin reductase 0.0017 0.0082 0.0713
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0543 0.095
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0872 0.239
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0202 0.1766
Mycobacterium ulcerans hypothetical protein 0.0017 0.0083 0.0118
Echinococcus granulosus lysine specific demethylase 5A 0.0096 0.1062 0.1251
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0015 0.0017
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0237 0.065
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0019 0.0034
Schistosoma mansoni chromobox protein 0.007 0.0747 0.0879
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0142 0.0389
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.004 0.004
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0407 0.1117
Onchocerca volvulus Adrenodoxin, mitochondrial homolog 0.0017 0.0087 0.0305
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0224
Echinococcus granulosus snurportin 1 0.0311 0.372 0.4381
Loa Loa (eye worm) hypothetical protein 0.0025 0.0188 0.0328
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0074 0.0204
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0034
Echinococcus multilocularis chromobox protein 1 0.007 0.0747 0.0747
Trichomonas vaginalis aldehyde oxidase, putative 0.0528 0.6396 1
Trichomonas vaginalis Ferredoxin 2 0.0017 0.0087 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0173 0.0303
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0054 0.054 0.0944
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0019 0.003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0002 0.0002
Echinococcus multilocularis X box binding protein 1 0.0291 0.3474 0.3474
Loa Loa (eye worm) beta-lactamase 0.0036 0.0327 0.0572
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0101 0.0157
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0173 0.0491
Echinococcus granulosus microtubule associated protein 2 0.0698 0.8492 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0165 0.1442
Mycobacterium tuberculosis Conserved protein 0.0036 0.0327 0.0447
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0074 0.0193
Echinococcus granulosus expressed protein 0.0034 0.0294 0.0346
Leishmania major ferredoxin 2fe-2s-like protein 0.0017 0.0087 0.0227
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0872 0.239
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0208 0.0245
Mycobacterium ulcerans hypothetical protein 0.0161 0.1863 0.2666
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0074 0.013
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0083 0.0227
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0692 0.0815
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0327 0.0511
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1056 0.1651
Mycobacterium ulcerans lipase LipD 0.0036 0.0327 0.0467
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0416 0.1142
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.004 0.007
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0622 0.1696
Loa Loa (eye worm) hypothetical protein 0.0053 0.0531 0.0929
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0019 0.017
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1224 0.1733
Loa Loa (eye worm) carboxylesterase 0.0011 0.0015 0.0026
Schistosoma mansoni hypothetical protein 0.0339 0.406 0.4781
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0202 0.0354
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0122 0.0144
Onchocerca volvulus 0.0011 0.0015 0.0052
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0122 0.0335
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0154 0.1776 0.2092
Schistosoma mansoni hypothetical protein 0.0084 0.0911 0.1073
Onchocerca volvulus 0.0011 0.0015 0.0052
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0233 0.2033
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1661 0.4555
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.003
Echinococcus granulosus epidermal growth factor receptor 0.0455 0.5491 0.6466
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0528 0.6396 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0086 0.0102
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.1659 0.2375
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0326 0.0384
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.1056 0.1849
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 0.3526 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1224 0.1733
Schistosoma mansoni DNA helicase recq5 0.0039 0.0358 0.0422
Mycobacterium tuberculosis Possible oxygenase 0.0017 0.0087 0.0103
Leishmania major GTP-binding protein, putative 0.0021 0.0142 0.0379
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0101 0.1122 0.1587
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0057 0.0089
Brugia malayi Thioredoxin reductase 0.0048 0.0467 0.0818
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0202 0.0202
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0872 0.239
Brugia malayi Carboxylesterase family protein 0.0066 0.0692 0.1211
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3526 0.5512
Echinococcus multilocularis chromobox protein 1 0.007 0.0747 0.0747
Toxoplasma gondii thioredoxin reductase 0.0048 0.0467 0.4083
Loa Loa (eye worm) histone methyltransferase 0.001 0.0002 0.0003
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0188 0.0221
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0084 0.0911 0.0911
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1224 0.1733
Trichomonas vaginalis spcc417.12 protein, putative 0.0011 0.0015 0.0023
Echinococcus multilocularis bloom syndrome protein 0.0066 0.0691 0.0691
Mycobacterium ulcerans hypothetical protein 0.0086 0.0937 0.1341
Plasmodium falciparum phd finger protein, putative 0.0029 0.0233 0.2033
Onchocerca volvulus 0.0036 0.0327 0.1149
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0015 0.0133
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0094 0.1041 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0415 0.0726
Mycobacterium ulcerans electron transfer protein 0.0017 0.0087 0.0124
Trypanosoma brucei DNA polymerase IV, putative 0.0074 0.0789 0.2164
Brugia malayi MH1 domain containing protein 0.0016 0.0078 0.0136
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.006 0.0622 0.5432
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0074 0.0649
Brugia malayi MH2 domain containing protein 0.0239 0.2824 0.4942
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3526 0.5512
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0178 0.2078 0.2974
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0019 0.017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3526 0.5512
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0054 0.054 0.054
Plasmodium falciparum ferredoxin, putative 0.0017 0.0087 0.0757
Schistosoma mansoni smad 0.0016 0.0078 0.0092
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0188 0.0515
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0234 0.0409
Brugia malayi Furin-like cysteine rich region family protein 0.0455 0.5491 0.9609
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0202 0.0573
Echinococcus granulosus lamin 0.0054 0.0543 0.0639
Loa Loa (eye worm) TK/EGFR protein kinase 0.0455 0.5491 0.9609
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1224 0.1733
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0019 0.017
Mycobacterium tuberculosis Conserved protein 0.0036 0.0327 0.0447
Brugia malayi chromobox protein homolog 3 0.0039 0.0365 0.0638
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0082 0.0143
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0112 0.0296
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0467 0.4082
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.04 0.0471
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1374 0.1949
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.003
Onchocerca volvulus 0.0024 0.0173 0.0609
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0101 0.1122 0.1605
Echinococcus granulosus neuroligin 0.0011 0.0015 0.0017
Echinococcus multilocularis microtubule associated protein 2 0.0698 0.8492 0.8492
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0249 0.2951 0.4222
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0327 0.0447
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0082 0.0713
Brugia malayi Flap endonuclease-1 0.0026 0.0202 0.0354
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0033 0.0281 0.0382
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0101 0.0157
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0178 0.2078 0.2959
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0002 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0543 0.095
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.054 0.0944
Loa Loa (eye worm) carboxylesterase 0.0066 0.0692 0.1211
Echinococcus multilocularis epidermal growth factor receptor 0.0455 0.5491 0.5491
Brugia malayi RNA, U transporter 1 0.0083 0.0901 0.1576
Echinococcus granulosus chromobox protein 1 0.007 0.0747 0.0879
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0327 0.0572
Echinococcus multilocularis ferredoxin adrenodoxin 0.0017 0.0087 0.0087
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0188 0.1639
Plasmodium falciparum glutathione reductase 0.0048 0.0467 0.4082
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0284 0.0779
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0082 0.0213
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0082 0.0224
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0294 0.0515
Brugia malayi MH2 domain containing protein 0.0016 0.0078 0.0136
Echinococcus granulosus Chromo domain 0.0012 0.0019 0.0023
Leishmania major importin beta-1 subunit, putative 0.0024 0.0169 0.0453
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3526 0.5512
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0015 0.0015
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0372 0.0372
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0284 0.0779
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.3647 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0198 0.0347
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0202 0.1766
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0101 0.0157
Trichomonas vaginalis chromobox protein, putative 0.007 0.0747 0.1168
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0015 0.0015
Schistosoma mansoni survival motor neuron protein 0.0096 0.1068 0.1257
Mycobacterium tuberculosis Probable reductase 0.0109 0.1224 0.1733
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0145 0.1671 0.1671
Loa Loa (eye worm) Smad1 0.0016 0.0078 0.0136
Schistosoma mansoni tyrosine kinase 0.0145 0.1671 0.1968
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0327 0.0572
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.2824 0.4942
Toxoplasma gondii ATPase, AAA family protein 0.001 0.00000034704 0.0000030314
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0019 0.003
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0188 0.0515
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0112 0.0139
Brugia malayi CHD4 protein 0.0013 0.004 0.007
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0112 0.0175
Mycobacterium ulcerans hypothetical protein 0.0036 0.0327 0.0467
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0082 0.0224
Brugia malayi Carboxylesterase family protein 0.0011 0.0015 0.0026
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0098 0.0858
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0327 0.0467
Entamoeba histolytica hypothetical protein 0.0012 0.0019 0.0055
Leishmania major trypanothione reductase 0.0048 0.0467 0.1272
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0034
Brugia malayi jmjC domain containing protein 0.0025 0.0188 0.0328
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0747 0.1307
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0173 0.0248
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0122 0.1068
Echinococcus multilocularis dna polymerase eta 0.0079 0.0858 0.0858
Onchocerca volvulus 0.0011 0.0015 0.0052
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0173 0.0227
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0303
Brugia malayi Carboxylesterase family protein 0.0011 0.0015 0.0026
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.00000034704 0.00000054258
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0082 0.0224
Loa Loa (eye worm) hypothetical protein 0.0024 0.0173 0.0303
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0173 0.0491
Schistosoma mansoni DNA polymerase IV / kappa 0.0017 0.0083 0.0097
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0188 0.0221
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0082 0.7298
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0082 0.0128
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0327 0.0327
Brugia malayi intermediate filament protein 0.0054 0.0543 0.095
Schistosoma mansoni kinase 0.0049 0.0476 0.0561
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0358 0.0627
Trypanosoma brucei NADH-ubiquinone oxidoreductase complex I subunit, putative 0.0017 0.0087 0.0238
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0078 0.0092
Entamoeba histolytica hypothetical protein 0.0036 0.0326 0.0925
Echinococcus granulosus chromobox protein 2 0.0012 0.0019 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0327 0.0385
Echinococcus multilocularis neuroligin 0.0011 0.0015 0.0015
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0142 0.0167
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0327 0.0385
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0024

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 10 uM Transactivation activity at PPARgamma (unknown origin) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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