Detailed information for compound 233077

Basic information

Technical information
  • TDR Targets ID: 233077
  • Name: 1-[2-(2-cyano-6-fluoro-3-methoxyphenyl)ethyl] -3-(5-cyanopyridin-2-yl)thiourea
  • MW: 355.389 | Formula: C17H14FN5OS
  • H donors: 1 H acceptors: 3 LogP: 2.52 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(OC)ccc(c1CC/N=C(/Nc1ccc(cn1)C#N)\S)F
  • InChi: 1S/C17H14FN5OS/c1-24-15-4-3-14(18)12(13(15)9-20)6-7-21-17(25)23-16-5-2-11(8-19)10-22-16/h2-5,10H,6-7H2,1H3,(H2,21,22,23,25)
  • InChiKey: XERIEOGWOGJQKP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(2-cyano-6-fluoro-3-methoxy-phenyl)ethyl]-3-(5-cyano-2-pyridyl)thiourea
  • 1-[2-(2-cyano-6-fluoro-3-methoxyphenyl)ethyl]-3-(5-cyano-2-pyridyl)thiourea
  • 1-[2-(2-cyano-6-fluoro-3-methoxy-phenyl)ethyl]-3-(5-cyanopyridin-2-yl)thiourea
  • 181305-34-0
  • AIDS-033462
  • AIDS033462
  • N-[2-(2-Cyano-3-methoxy-6-fluorophenethyl)]-N'-[2-(5-cyanopyridyl)]thiourea
  • Thiourea, N-[2-(2-cyano-6-fluoro-3-methoxyphenyl)ethyl]-N'-(5-cyano-2-pyridinyl)-
  • LY300046HCl Analog 18
  • N-(2-(2-Cyano-3-methoxy-6-fluorophenethyl))-N'-(2-(5-cyanopyridyl))thiourea
  • Thiourea, N-(2-(2-cyano-6-fluoro-3-methoxyphenyl)ethyl)-N'-(5-cyano-2-pyridinyl)-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni patched 1 0.0044 0.0196 0.0198
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.005 0.005
Brugia malayi Doublecortin family protein 0.0044 0.0201 0.0917
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.003 0.0128
Echinococcus multilocularis protein dispatched 1 0.005 0.0238 0.0241
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.003 0.0025
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0078 0.0431 0.1043
Brugia malayi PHD-finger family protein 0.0035 0.0134 0.0611
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0152 0.0361
Mycobacterium tuberculosis Probable succinate dehydrogenase (flavoprotein subunit) SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogena 0.0022 0.0051 0.0051
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0152 0.0361
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.0218 0.2982
Loa Loa (eye worm) hypothetical protein 0.0028 0.0089 0.0402
Schistosoma mansoni alpha-glucosidase 0.0145 0.0888 0.0906
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0152 0.0361
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0192
Trypanosoma brucei mercaptopyruvate sulfurtransferase, putative 0.0016 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0052 0.0256 0.1172
Brugia malayi TAZ zinc finger family protein 0.0113 0.0675 0.3103
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0124 0.0746 0.0761
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0195 0.0951
Toxoplasma gondii histone lysine methyltransferase SET1 0.0122 0.0732 1
Mycobacterium ulcerans succinate dehydrogenase flavoprotein subunit 0.0022 0.0051 0.0046
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0044 0.0043
Treponema pallidum NADH oxidase 0.0023 0.0053 0.0056
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0195 0.0466
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0011 0.0147
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0011 0.0009
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0234 0.0237
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.027 0.0274
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0044 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0123 0.0594
Brugia malayi polk-prov protein 0.0033 0.0123 0.0556
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0196 0.0893
Leishmania major As/Sb Reductase 0.0016 0.0005 0.0015
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.008 0.0383
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0053 0.025
Entamoeba histolytica hypothetical protein 0.0016 0.0005 0.0012
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0053 0.0117
Echinococcus granulosus protein quaking 0.0028 0.0089 0.0089
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0053 0.072
Schistosoma mansoni hypothetical protein 0.0042 0.0185 0.0187
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.0095 0.046
Trypanosoma cruzi Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0022 0.0051 0.0242
Chlamydia trachomatis succinate dehydrogenase flavoprotein subunit 0.0022 0.0051 0.4931
Entamoeba histolytica hypothetical protein 0.0016 0.0005 0.0012
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0152 0.0361
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0017 0.0075
Leishmania major eukaryotic translation initiation factor-like 0.0036 0.0141 0.0683
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0192
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0044 0.0192
Schistosoma mansoni cpg binding protein 0.0065 0.0345 0.0351
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0017 0.0075
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0036 0.0141 0.1923
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0361 0.1656
Brugia malayi MoeZ/MoeB domain containing protein 0.0016 0.0005 0.0014
Echinococcus granulosus dual specificity mitogen activated protein 0.0079 0.0439 0.0447
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.4086 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.003 0.0029
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0036 0.0141 0.0142
Loa Loa (eye worm) inositol-1 0.0039 0.0165 0.0752
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0195 0.0466
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.006 0.0266
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0044 0.0043
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0281 0.0285
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0228 0.8695
Plasmodium falciparum glutathione reductase 0.0023 0.0053 0.186
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0016 0.0005 0.0015
Echinococcus multilocularis caspase 0.0124 0.0746 0.0761
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0005 0.0015
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0016 0.0005 0.0003
Wolbachia endosymbiont of Brugia malayi succinate dehydrogenase iron-sulfur subunit 0.0053 0.0261 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0201 0.0917
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0011 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0195 0.0951
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0152 0.0361
Schistosoma mansoni DNA helicase recq1 0.0029 0.0099 0.0099
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0049 0.023 0.0233
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0152 0.0741
Trypanosoma cruzi ISWI complex protein 0.0016 0.0005 0.0015
Echinococcus multilocularis protein quaking 0.0028 0.0089 0.0089
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0078 0.0431 0.1043
Schistosoma mansoni hypothetical protein 0.0021 0.0043 0.0042
Plasmodium falciparum thioredoxin reductase 0.0048 0.0227 0.8681
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0593 0.1451
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0311 0.2032 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0218 0.0522
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0014
Trypanosoma cruzi metacaspase, putative 0.0047 0.0218 0.1065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0014
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0124 0.0746 0.0761
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0005 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0044 0.0192
Schistosoma mansoni ap endonuclease 0.0019 0.003 0.0028
Onchocerca volvulus Ribonuclease H1 homolog 0.0027 0.008 0.134
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.0015
Loa Loa (eye worm) acetyltransferase 0.0154 0.0951 0.4377
Schistosoma mansoni lipoxygenase 0.0199 0.126 0.1285
Brugia malayi hypothetical protein 0.0044 0.0196 0.0895
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0099 0.0231
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0079 0.0439 0.2017
Echinococcus granulosus RUN 0.0044 0.0201 0.0203
Brugia malayi RNase H family protein 0.0027 0.008 0.0359
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0281 0.0285
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) iron sulfur 0.0034 0.013 0.0131
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0044 0.0192
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.008 0.0079
Schistosoma mansoni cpg binding protein 0.0065 0.0345 0.0351
Brugia malayi succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial 0.0053 0.0261 0.1196
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) 0.0022 0.0051 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.4086 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0044 0.0043
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0151 0.0152
Schistosoma mansoni lipoxygenase 0.0119 0.0713 0.0726
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.027 0.065
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Brugia malayi Temporarily assigned gene name protein 44 0.0028 0.0089 0.0402
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0165 0.0392
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0309 0.1413
Loa Loa (eye worm) hypothetical protein 0.0062 0.0323 0.1478
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.0015
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0053 0.186
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0195 0.0951
Leishmania major eukaryotic translation initiation factor-like protein 0.0036 0.0141 0.0683
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.0638 0.0658
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0195 0.0951
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0165 0.0804
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0298 0.1943 0.1939
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0049 0.023 0.0233
Echinococcus granulosus Polycystic kidney disease protein 0.0044 0.0201 0.0203
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0141 0.0332
Echinococcus granulosus 5'partial|tRNA 2 selenouridine synthase 0.0016 0.0005 0.0003
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) 0.0016 0.0005 0.0003
Loa Loa (eye worm) RecQ helicase 0.0042 0.0188 0.0857
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0044 0.0043
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.003 0.0966
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0314 0.0318
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0095 0.046
Brugia malayi Bromodomain containing protein 0.0045 0.0206 0.0939
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0152 0.0154
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0228 0.3115
Toxoplasma gondii succinate dehydrogenase [ubiquinone] iron-sulfur protein 0.0053 0.0261 0.3572
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0044 0.0043
Trichomonas vaginalis DNA helicase recq, putative 0.0032 0.0118 0.0276
Echinococcus multilocularis caspase 3 0.0077 0.0425 0.0432
Mycobacterium tuberculosis Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) 0.0022 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0196 0.0467
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.005 0.0236
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0011 0.0041
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0197 0.0961
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0234 0.0237
Mycobacterium tuberculosis Possible transcriptional regulatory protein (possibly ArsR-family) 0.0016 0.0005 0.0003
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0234 0.0237
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0016 0.0005 0.0015
Trypanosoma cruzi As/Sb Reductase, putative 0.0016 0.0005 0.0015
Onchocerca volvulus 0.0044 0.0201 0.351
Echinococcus granulosus CREB binding protein 0.0018 0.0018 0.0016
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0199 0.126 0.1285
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0044 0.0043
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0049 0.023 0.0236
Chlamydia trachomatis succinate dehydrogenase iron sulfur subunit 0.0029 0.0098 1
Mycobacterium tuberculosis Probable molybdenum cofactor biosynthesis protein MoeB2 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase) 0.0016 0.0005 0.0003
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0044 0.0043
Schistosoma mansoni DNA helicase recq5 0.0029 0.0099 0.0099
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0099 0.0449
Schistosoma mansoni zinc finger protein 0.0029 0.0097 0.0097
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.0188 0.0857
Mycobacterium leprae Probable succinate dehydrogenase (flavoprotein subunit) SdhA (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHYDROGENA 0.0022 0.0051 0.0046
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0011 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0195 0.0951
Mycobacterium ulcerans hypothetical protein 0.0164 0.1022 0.1017
Echinococcus multilocularis ribonuclease H1 0.0027 0.008 0.008
Brugia malayi ecdysteroid receptor 0.0021 0.0044 0.0192
Schistosoma mansoni cpg binding protein 0.006 0.0309 0.0313
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0151 0.0152
Echinococcus granulosus CREB binding protein 0.0072 0.0393 0.0399
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0281 0.0285
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.027 0.1237
Brugia malayi jmjC domain containing protein 0.0017 0.0011 0.0041
Echinococcus multilocularis Rhodanese 0.0016 0.0005 0.0003
Trypanosoma cruzi succinate dehydrogenase, putative 0.0034 0.013 0.0633
Schistosoma mansoni succinate dehydrogenase iron-sulfur protein 0.0053 0.0261 0.0265
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.038 0.0387
Schistosoma mansoni hypothetical protein 0.0044 0.0196 0.0198
Schistosoma mansoni hypothetical protein 0.0303 0.1974 0.2015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0192
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.0015
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0035 0.0134 0.0129
Loa Loa (eye worm) hypothetical protein 0.0029 0.0099 0.0449
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.0015
Trypanosoma brucei NADH dehydrogenase 0.0035 0.0134 0.065
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0298 0.1943 0.2009
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0049 0.023 0.0552
Schistosoma mansoni alpha glucosidase 0.0037 0.0152 0.0154
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.0951 0.097
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.027 0.1322
Brugia malayi jmjC domain containing protein 0.0017 0.0011 0.0041
Entamoeba histolytica rodhanase-like domain containing protein 0.0078 0.0431 0.1054
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0173 0.6558
Echinococcus multilocularis CREB binding protein 0.0018 0.0018 0.0016
Mycobacterium tuberculosis Conserved protein 0.0016 0.0005 0.0003
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0005 0.0012
Trypanosoma brucei metacaspase MCA2 0.0047 0.0218 0.1065
Trypanosoma brucei RNA helicase, putative 0.01 0.0583 0.2862
Onchocerca volvulus 0.0021 0.0044 0.0692
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0011 0.0009
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0079 0.0439 0.2155
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0228 0.0231
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.027 0.0274
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0016 0.0005 0.0015
Brugia malayi MAP kinase sur-1 0.0054 0.027 0.1237
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0017 0.0075
Brugia malayi Thioredoxin reductase 0.0048 0.0227 0.104
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0053 0.186
Plasmodium vivax JmjC domain containing protein 0.0017 0.0011 0.0223
Echinococcus granulosus cpg binding protein 0.0065 0.0345 0.0351
Trypanosoma brucei Metacaspase-4 0.0047 0.0218 0.1065
Mycobacterium tuberculosis Probable dehydrogenase 0.0098 0.057 0.0588
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.007 0.2545
Leishmania major hypothetical protein, conserved 0.0029 0.0098 0.0475
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0049 0.023 0.1124
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0324 0.0329
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0036 0.0141 0.0683
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.003 0.0028
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.003 0.0137
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0192
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0005 0.0015
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0005 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0044 0.0192
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0078 0.0431 0.1043
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0044 0.0196 0.0893
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.1253 0.1278
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.003 0.0061
Trypanosoma cruzi NADH dehydrogenase, putative 0.0035 0.0134 0.065
Brugia malayi Rhodanese-like domain containing protein 0.0016 0.0005 0.0014
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0201 0.0203
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0079 0.0439 0.2017
Trypanosoma cruzi succinate dehydrogenase iron-sulfur subunit 0.0034 0.013 0.0633
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0152 0.0741
Trypanosoma cruzi succinate dehydrogenase iron-sulfur subunit 0.0029 0.0098 0.0475
Entamoeba histolytica recQ family helicase, putative 0.0032 0.0118 0.0288
Brugia malayi jmjC domain containing protein 0.0017 0.0011 0.0041
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0118 0.0569
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.1473 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0195 0.0951
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0196 0.0198
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0049 0.023 0.8789
Toxoplasma gondii flavoprotein subunit of succinate dehydrogenase 0.0022 0.0051 0.0698
Schistosoma mansoni dual specificity protein phosphatase 0.002 0.0036 0.0035
Onchocerca volvulus 0.006 0.0309 0.5438
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0298 0.1943 0.1939
Echinococcus granulosus Rhodanese 0.0016 0.0005 0.0003
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.1253 0.1278
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0044 0.0043
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0118 0.0569
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0026 0.0025
Entamoeba histolytica rodhanase-like domain containing protein 0.0016 0.0005 0.0012
Mycobacterium tuberculosis Probable fumarate reductase [flavoprotein subunit] FrdA (fumarate dehydrogenase) (fumaric hydrogenase) 0.0022 0.0051 0.0051
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0029 0.0095 0.046
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0314 0.1437
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0192
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0017 0.0016
Mycobacterium tuberculosis Probable reductase 0.0098 0.057 0.0588
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0192
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0611 0.4086 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0053 0.025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0014
Trypanosoma brucei ribonuclease H1 0.0027 0.008 0.0383
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0195 0.019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0338 0.0333
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0053 0.025
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0035 0.0134 0.5034
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0234 0.0237
Echinococcus granulosus ribonuclease H1 0.0027 0.008 0.008
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0024 0.0023
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0049 0.023 0.1053
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0123 0.0594
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0152 0.0741
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0338 0.0348
Echinococcus multilocularis caspase 2 0.009 0.0517 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0044 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0218 0.0522
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0026 0.0025
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0053 0.186
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase CysA2 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotran 0.0016 0.0005 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0236
Schistosoma mansoni hypothetical protein 0.0044 0.0201 0.0203
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.0049 0.023 0.0225
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0141 0.0332
Brugia malayi translation initiation factor 4E 0.0036 0.0141 0.064
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0218 0.8318
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0011 0.0009
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0044 0.0043
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0338 0.0333
Echinococcus granulosus apoptotic protease activating factor 1 0.0044 0.0196 0.0198
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0049 0.023 0.0233
Trypanosoma cruzi metacaspase 5, putative 0.0047 0.0218 0.1065
Plasmodium falciparum iron-sulfur subunit of succinate dehydrogenase 0.0053 0.0261 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0098 0.057 0.0588
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0026 0.0025
Brugia malayi succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0022 0.0051 0.0226
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0907 0.446
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0011 0.0009
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0314 0.0318
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0053 0.025
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0044 0.0043
Brugia malayi RNase H family protein 0.0027 0.008 0.0359
Toxoplasma gondii ribonuclease HI protein 0.0027 0.008 0.1091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0192
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0165 0.0167
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.0951 0.097
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0017 0.0016
Echinococcus multilocularis CREB binding protein 0.008 0.0444 0.0451
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0036 0.0141 0.0344
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0197 0.0961
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.003 0.0137
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0152 0.0154
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0218 0.0522
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0907 0.446
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0044 0.0192
Trypanosoma cruzi metacaspase, putative 0.0047 0.0218 0.1065
Brugia malayi jmjC domain containing protein 0.0068 0.0361 0.1656
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.0218 0.2982
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0324 0.0329
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0099 0.0449
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0044 0.0192
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0324 0.0329
Trypanosoma cruzi metacaspase, putative 0.0047 0.0218 0.1065
Onchocerca volvulus Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial homolog 0.0022 0.0051 0.0825
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) iron sulfur 0.0053 0.0261 0.0265
Schistosoma mansoni succinate dehydrogenase iron-sulfur protein 0.0029 0.0098 0.0099
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.0892 0.0909
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0338 0.0343
Echinococcus multilocularis neuropeptide s receptor 0.0477 0.3166 0.3233
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0338 0.1655
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0053 0.025
Loa Loa (eye worm) glutathione reductase 0.0048 0.0227 0.104
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0079 0.0439 0.2155
Schistosoma mansoni bromodomain containing protein 0.0074 0.0406 0.0413
Echinococcus granulosus caspase 2 0.009 0.0517 0.0527
Loa Loa (eye worm) hypothetical protein 0.0073 0.0397 0.1821
Trypanosoma cruzi ISWI complex protein 0.0016 0.0005 0.0015
Brugia malayi Rhodanese-like domain containing protein 0.0078 0.0431 0.1977
Onchocerca volvulus Cell death protein 3 homolog 0.009 0.0517 0.9182
Leishmania major hypothetical protein, conserved 0.0017 0.0011 0.0043
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0152 0.0361
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.027 0.0274
Loa Loa (eye worm) MBCTL1 0.0056 0.0281 0.1286
Trypanosoma brucei succinate dehydrogenase iron-sulfur subunit, putative 0.0034 0.013 0.0633
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0016 0.0005 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0195 0.0951
Trichomonas vaginalis cdc25b, putative 0.0078 0.0431 0.1043
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.0016 0.0005 0.0003
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.0005 0.0012
Schistosoma mansoni inositol monophosphatase 0.0039 0.0165 0.0167
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0011 0.0009
Echinococcus multilocularis microtubule associated protein 2 0.1442 0.9789 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0604 0.0615
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0044 0.0192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.4086 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0323 0.1478
Onchocerca volvulus 0.0097 0.0563 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.4086 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0195 0.0951
Trichomonas vaginalis ribonuclease H1, putative 0.0027 0.008 0.0183
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0035 0.0134 0.5034
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0011 0.0041
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0314 0.0309
Schistosoma mansoni hypothetical protein 0.0042 0.0185 0.0187
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0053 0.025
Brugia malayi nuclear receptor NHR-88 0.0021 0.0044 0.0192
Brugia malayi jmjC domain containing protein 0.0017 0.0011 0.0041
Loa Loa (eye worm) hypothetical protein 0.0033 0.0123 0.0556
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0281 0.0285
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.0638 0.0658
Trypanosoma brucei unspecified product 0.0029 0.0095 0.046
Brugia malayi glutathione reductase 0.0048 0.0227 0.104
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0024 0.0023
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.2032 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0152 0.0361
Brugia malayi jmjC domain containing protein 0.0062 0.0324 0.1485
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0014
Echinococcus granulosus CREB binding protein 0.0113 0.0675 0.0688
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0314 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0044 0.0192
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0199 0.126 0.1285
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0044 0.0043
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0049 0.023 0.0552
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0338 0.4619
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0053 0.0117
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0218 0.0522
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0338 0.0343
Echinococcus multilocularis caspase 8 0.0047 0.0218 0.0221
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0611 0.4086 1
Brugia malayi hypothetical protein 0.0028 0.0089 0.0402
Trichomonas vaginalis STE family protein kinase 0.0079 0.0439 0.1064
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0195 0.0951
Schistosoma mansoni rab6-interacting 0.0044 0.0201 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0218 0.0522
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0152 0.2084
Trypanosoma cruzi mercaptopyruvate sulfurtransferase, putative 0.0016 0.0005 0.0015
Schistosoma mansoni zinc finger protein 0.0016 0.0005 0.0003
Loa Loa (eye worm) doublecortin family protein 0.0044 0.0201 0.0917
Plasmodium falciparum metacaspase 1 0.0047 0.0218 0.8318
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.027 0.065
Treponema pallidum fructose-bisphosphate aldolase 0.0611 0.4086 1
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0338 0.0343
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.003 0.0073
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.003 0.0137
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0049 0.023 0.1124
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0043 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0044 0.0192
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0227 0.104
Trichomonas vaginalis STE family protein kinase 0.0079 0.0439 0.1064
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.0892 0.0909
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0005 0.0015
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0036 0.0141 0.0683
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0165 0.016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0044 0.0043
Echinococcus multilocularis zinc finger protein 0.0029 0.0097 0.0097
Schistosoma mansoni rab6-interacting 0.0044 0.0201 0.0203
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0314 0.0318
Entamoeba histolytica rodhanase-like domain containing protein 0.0078 0.0431 0.1054
Schistosoma mansoni microtubule-associated protein tau 0.1442 0.9789 1
Loa Loa (eye worm) thiosulfate sulfurtransferase 0.0016 0.0005 0.0014
Echinococcus granulosus centrosomal protein of 41 kDa 0.0016 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0056 0.0281 0.1286
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0053 0.025
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0078 0.0431 0.0438
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0218 0.0522
Wolbachia endosymbiont of Brugia malayi succinate dehydrogenase flavoprotein subunit 0.0022 0.0051 0.1796
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0195 0.0951
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0263 0.1285
Schistosoma mansoni inositol monophosphatase 0.0039 0.0165 0.0167
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0053 0.0052
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0047 0.0218 0.0221
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.4086 1
Echinococcus granulosus dnaJ subfamily B 0.0855 0.576 0.5883
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0044 0.0192
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1424 0.9667 1
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0173 0.0412
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0044 0.0043
Echinococcus multilocularis centrosomal protein of 41 kDa 0.0016 0.0005 0.0003
Mycobacterium tuberculosis Probable transcriptional regulatory protein 0.0016 0.0005 0.0003
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0053 0.072
Schistosoma mansoni hypothetical protein 0.0028 0.0089 0.0089
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0165 0.0404
Brugia malayi Rhodanese-like domain containing protein 0.0078 0.0431 0.1977
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0011 0.0041
Echinococcus granulosus tumor protein p63 0.0358 0.2351 0.2401
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0036 0.0157
Plasmodium vivax iron-sulfur subunit of succinate dehydrogenase, putative 0.0053 0.0261 1
Echinococcus multilocularis tRNA 2 selenouridine synthase 0.0016 0.0005 0.0003
Mycobacterium ulcerans succinate dehydrogenase iron-sulfur subunit 0.0029 0.0098 0.0093
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0005 0.0015
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0152 0.0694
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0053 0.186
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.027 0.065
Leishmania major mitochondrial DNA polymerase beta 0.0311 0.2032 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0098 0.057 0.0588
Entamoeba histolytica rodhanase-like domain containing protein 0.0016 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0192
Loa Loa (eye worm) translation initiation factor 4E 0.0036 0.0141 0.064
Entamoeba histolytica rodhanase-like domain containing protein 0.0016 0.0005 0.0012
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.038 0.0387
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0234 0.107
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.0907 0.446
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.077 0.0785
Echinococcus granulosus succinate dehydrogenase ubiquinone 0.0022 0.0051 0.005
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0152 0.0373
Loa Loa (eye worm) hypothetical protein 0.0101 0.0593 0.2725
Trypanosoma brucei metacaspase MCA3 0.0047 0.0218 0.1065
Echinococcus granulosus dna polymerase kappa 0.0043 0.0195 0.0197
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0085 0.0084
Schistosoma mansoni polycystin 1-related 0.0044 0.0201 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0044 0.0192
Schistosoma mansoni phosphoglucomutase 0.0027 0.008 0.008
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0053 0.025
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1049 0.107
Schistosoma mansoni alpha-glucosidase 0.0145 0.0888 0.0906
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.027 0.0274
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.0893 0.091
Leishmania major NADH dehydrogenase, putative 0.0035 0.0134 0.065
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0314 0.1535
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0231 0.0234
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0218 0.0522
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0011 0.0009
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.0201 0.7644
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.027 0.065
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0023 0.0053 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.4086 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.027 0.1322
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.0638 0.0658
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.027 0.1322
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.003 0.0061
Trypanosoma brucei Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0022 0.0051 0.0242
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0049 0.023 0.8789
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0044 0.0192
Plasmodium falciparum metacaspase-like protein 0.0047 0.0218 0.8318
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0593 0.0604
Mycobacterium tuberculosis Probable fumarate reductase [iron-sulfur subunit] FrdB (fumarate dehydrogenase) (fumaric hydrogenase) 0.0029 0.0098 0.01
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0228 0.3115
Loa Loa (eye worm) hypothetical protein 0.0053 0.026 0.1189
Schistosoma mansoni caspase-7 (C14 family) 0.009 0.0517 0.0527
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0035 0.0134 0.1832
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0041
Echinococcus multilocularis CREB binding protein 0.0018 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0048 0.0223 0.1019
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0152 0.0373
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0036 0.0141 0.0683
Brugia malayi succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0022 0.0051 0.0226
Toxoplasma gondii hypothetical protein 0.005 0.0241 0.3298
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0078 0.0431 0.1043
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0197 0.0961
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0011 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0011 0.0043
Echinococcus granulosus caspase 3 0.0077 0.0425 0.0432
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0218 0.0522
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.004 0.0168 0.0766
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0078 0.0431 0.0438
Loa Loa (eye worm) hypothetical protein 0.0078 0.0431 0.1977
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0053 0.0234
Entamoeba histolytica hypothetical protein 0.0016 0.0005 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0044 0.0192
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0041
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0026 0.0025
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0165 0.2257
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0234 0.0237
Onchocerca volvulus Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial homolog 0.0022 0.0051 0.0825
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.0095 0.046
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase CysA3 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotran 0.0016 0.0005 0.0003
Trypanosoma brucei protein kinase, putative 0.0054 0.027 0.1322
Brugia malayi RIKEN cDNA 4930451A13 0.0016 0.0005 0.0014
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0003
Entamoeba histolytica hypothetical protein 0.0016 0.0005 0.0012
Onchocerca volvulus 0.0078 0.0431 0.763
Trichomonas vaginalis cdc25c, putative 0.0078 0.0431 0.1043
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0228 0.0546
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0227 0.8681
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.072 0.0742
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0195 0.0951
Trypanosoma brucei succinate dehydrogenase iron-sulfur subunit 0.0029 0.0098 0.0475
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.027 0.1322
Echinococcus granulosus succinate dehydrogenase ubiquinone iron sulfur 0.0024 0.006 0.0059
Loa Loa (eye worm) hypothetical protein 0.005 0.0242 0.1109
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0195 0.019
Echinococcus multilocularis tumor protein p63 0.0358 0.2351 0.2401
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0011 0.0043
Echinococcus multilocularis neuropeptide receptor A26 0.0477 0.3166 0.3233
Loa Loa (eye worm) hypothetical protein 0.0053 0.0263 0.1203
Brugia malayi Bromodomain containing protein 0.0086 0.0489 0.2244
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.0188 0.0448
Entamoeba histolytica rodhanase-like domain containing protein 0.0078 0.0431 0.1054
Loa Loa (eye worm) hypothetical protein 0.0047 0.0218 0.0997
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0036 0.0141 0.0683
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0201 0.0203
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0165 0.6248
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0044 0.0043
Trypanosoma cruzi NADH dehydrogenase, putative 0.0035 0.0134 0.065
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0281 0.1286
Loa Loa (eye worm) hypothetical protein 0.0049 0.0234 0.107
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0218 0.0522
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase SseB 0.0016 0.0005 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0044 0.0192
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0044 0.0043
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0078 0.0431 0.1043
Echinococcus multilocularis heat shock protein 67b2 0.0016 0.0005 0.0003
Echinococcus granulosus succinate dehydrogenase (ubiquinone) iron sulfur 0.0053 0.0261 0.0265
Loa Loa (eye worm) hypothetical protein 0.0044 0.0201 0.0917
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0036 0.0141 0.0344
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0044 0.0043
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0023 0.0053 0.0052
Plasmodium falciparum thioredoxin reductase 0.0023 0.0053 0.186
Leishmania major succinate dehydrogenase, putative 0.0034 0.013 0.0633
Onchocerca volvulus 0.0078 0.0431 0.763
Plasmodium vivax glutathione reductase, putative 0.0048 0.0227 0.8681
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0165 0.0804
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.027 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0218 0.0522
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0195 0.0951
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0053 0.0052
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0099 0.3676
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.027 0.1322
Brugia malayi Inositol-1 0.0039 0.0165 0.0752
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0218 0.0522
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.0015
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0044 0.0192
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0036 0.0141 0.0142
Schistosoma mansoni ap endonuclease 0.0019 0.003 0.0028
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0099 0.0099
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.008 0.0079
Trypanosoma brucei unspecified product 0.0036 0.0147 0.0715
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0141 0.0332
Plasmodium vivax metacaspase 1, putative 0.0047 0.0218 0.8318
Echinococcus granulosus lipoxygenase domain containing protein 0.0044 0.0201 0.0203
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0109
Echinococcus multilocularis Polycystic kidney disease protein 0.0044 0.0201 0.0203
Echinococcus granulosus neuropeptide receptor A26 0.0477 0.3166 0.3233
Mycobacterium ulcerans succinate dehydrogenase flavoprotein subunit 0.0022 0.0051 0.0046
Echinococcus multilocularis cpg binding protein 0.0065 0.0345 0.0351
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0079 0.0439 0.2155
Plasmodium vivax multidomain scavenger receptor, putative 0.0044 0.0201 0.7644
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0044 0.0043
Leishmania major hypothetical protein, conserved 0.0016 0.0005 0.0015
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0048 0.0047
Brugia malayi nuclear hormone receptor 0.0021 0.0044 0.0192
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0152 0.0361
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.003 0.0128
Echinococcus granulosus heat shock protein 67b2 0.0016 0.0005 0.0003
Echinococcus granulosus microtubule associated protein 2 0.1442 0.9789 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0218 0.0522
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0195 0.0951
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0099 0.1357
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.1049 0.4827
Giardia lamblia Fructose-bisphosphate aldolase 0.0611 0.4086 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0017 0.0016
Schistosoma mansoni CREB-binding protein 2 0.0113 0.0675 0.0688
Schistosoma mansoni protein kinase 0.0079 0.0439 0.0447
Schistosoma mansoni hypothetical protein 0.0042 0.0185 0.0187
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0049 0.023 0.3147
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0003
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0049 0.023 0.0563
Echinococcus granulosus expressed conserved protein 0.0095 0.0551 0.0561
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0047 0.0218 0.0997
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0044 0.0192
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0005 0.0003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0165 0.0804
Trypanosoma brucei glucosidase, putative 0.0037 0.0152 0.0741
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0032 0.0118 0.0569
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.0638 0.0633
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0024 0.0102
Onchocerca volvulus 0.0078 0.0431 0.763
Plasmodium vivax flavoprotein subunit of succinate dehydrogenase, putative 0.0022 0.0051 0.1796
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0044 0.0692
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Echinococcus multilocularis apoptotic protease activating factor 1 0.0044 0.0196 0.0198
Trypanosoma brucei ISWI complex protein 0.0016 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0113
Brugia malayi CHE-14 protein 0.0044 0.0196 0.0893
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.003 0.0137
Giardia lamblia DINP protein human, muc B family 0.0022 0.005 0.011
Leishmania major DNA polymerase kappa, putative 0.0022 0.005 0.0236
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.072 0.0742
Echinococcus multilocularis succinate dehydrogenase iron sulfur protein 0.0029 0.0098 0.0099
Brugia malayi mbt repeat family protein 0.0049 0.0234 0.107
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0044 0.0192
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0218 0.0522
Onchocerca volvulus 0.0078 0.0431 0.763
Onchocerca volvulus 0.0052 0.0256 0.4499
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0044 0.0043
Toxoplasma gondii rhodanese family domain-containing protein 0.0016 0.0005 0.0069
Mycobacterium tuberculosis Probable succinate dehydrogenase (iron-sulphur protein subunit) SdhB (succinic dehydrogenase) (fumarate reductase) (fumarate deh 0.0029 0.0098 0.01
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0053 0.0117
Loa Loa (eye worm) CBP-B 0.0081 0.045 0.2066
Leishmania major trypanothione reductase 0.0048 0.0227 0.1111
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0014
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0011 0.0009
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0099 0.0449
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.1049 0.4827
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0044 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0044 0.0192
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0011 0.0009
Treponema pallidum ribonuclease H (rnhA) 0.0027 0.008 0.0123
Loa Loa (eye worm) hypothetical protein 0.009 0.0517 0.2377
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0152 0.0694
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0049 0.023 0.1124
Schistosoma mansoni caspase-7 (C14 family) 0.0124 0.0746 0.0761
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0044 0.0192
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0256 0.026
Echinococcus granulosus caspase 0.0124 0.0746 0.0761
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0014
Toxoplasma gondii thioredoxin reductase 0.0048 0.0227 0.311
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0196 0.0198
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Schistosoma mansoni Centrosomal protein of 41 kDa (Cep41 protein) (Testis-specificprotein A14 protein) 0.0016 0.0005 0.0003
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0005 0.0015
Schistosoma mansoni hypothetical protein 0.0855 0.576 0.5883
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0152 0.0361
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0165 0.0167
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0311 0.2032 1
Schistosoma mansoni coup transcription factor 0.0021 0.0044 0.0043
Leishmania major 3-mercaptopyruvate sulfurtransferase 0.0016 0.0005 0.0015
Trypanosoma cruzi metacaspase 5, putative 0.0047 0.0218 0.1065
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0173 0.0424
Echinococcus granulosus lysine specific demethylase 5A 0.0068 0.0361 0.0367
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0049 0.023 0.1053
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0044 0.0692
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.1049 0.107
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.003 0.0966
Schistosoma mansoni phosphoglucomutase 0.0027 0.008 0.008
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0234 0.0237
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0049 0.023 0.1124
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0023 0.0053 0.5105
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0041
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0141 0.0332
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0231 0.0234
Echinococcus multilocularis lipoxygenase domain containing protein 0.0044 0.0201 0.0203
Loa Loa (eye worm) hypothetical protein 0.0028 0.0089 0.0399
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0016 0.0005 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0195 0.0951
Brugia malayi Cell death protein 3 precursor 0.009 0.0517 0.2377
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0218 0.0522
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0044 0.0043
Mycobacterium tuberculosis Conserved hypothetical protein 0.0164 0.1022 0.1055
Mycobacterium ulcerans fumarate reductase iron-sulfur subunit 0.0019 0.0028 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0195 0.0951
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0044 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0044 0.0192
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0047 0.0218 0.2982
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.4086 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0011 0.0147
Echinococcus multilocularis CREB binding protein 0.0018 0.0018 0.0016
Schistosoma mansoni succinate dehydrogenase 0.0022 0.0051 0.005
Trypanosoma brucei metacaspase 5, putative 0.0047 0.0218 0.1065
Echinococcus multilocularis protein patched 0.0044 0.0196 0.0198
Echinococcus granulosus caspase 8 0.0047 0.0218 0.0221
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.0951 0.4377
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0137 0.0132
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0044 0.0043
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0044 0.0692
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0044 0.0043
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0066 0.0907
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0053 0.186
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0197 0.0961
Loa Loa (eye worm) succinate dehydrogenase iron-sulfur protein 0.0053 0.0261 0.1196
Brugia malayi hypothetical protein 0.0044 0.0201 0.0917
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0228 0.0546
Trichomonas vaginalis cdc25b, putative 0.0078 0.0431 0.1043
Schistosoma mansoni loxhd1 0.0044 0.0201 0.0203
Onchocerca volvulus 0.0044 0.0196 0.3424
Echinococcus multilocularis bloom syndrome protein 0.0042 0.0188 0.019
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0023 0.0053 0.0048
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0053 0.0052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0338 0.0333
Trypanosoma cruzi metacaspase, putative 0.0047 0.0218 0.1065
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0593 0.0604
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0165 0.0804
Giardia lamblia Kinase, STE STE20 0.0079 0.0439 0.1064
Echinococcus granulosus succinate dehydrogenase ubiquinone iron sulfur 0.0053 0.0261 0.0265
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0281 0.0285
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0049 0.023 0.0563
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0036 0.0141 0.0142
Brugia malayi mbt repeat family protein 0.0049 0.0234 0.107
Brugia malayi steroid hormone receptor 0.0021 0.0044 0.0192
Loa Loa (eye worm) tumor suppressor 0.0331 0.2171 1
Trypanosoma brucei trypanothione reductase 0.0048 0.0227 0.1111
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0227 0.1111
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0285 0.1307
Brugia malayi CXXC zinc finger family protein 0.006 0.0309 0.1413
Echinococcus granulosus phd:f box containing protein 0.0017 0.0011 0.0009
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.027 0.1322
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.017 0.6419
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0099 0.0099
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.023 0.0236
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0195 0.0197
Echinococcus multilocularis RUN 0.0044 0.0201 0.0203
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0003
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0234 0.4104
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0078 0.0431 0.0438
Schistosoma mansoni ubiquitin-activating enzyme E1 0.0016 0.0005 0.0003
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.003 0.0966
Brugia malayi tumor suppressor. 0.0331 0.2171 1
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.027 0.065
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0099 0.1357
Onchocerca volvulus 0.0044 0.0201 0.351
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0147 0.0715
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Leishmania major ribonuclease H1, putative 0.0027 0.008 0.0383
Trypanosoma brucei metacaspase 0.0047 0.0218 0.1065
Echinococcus granulosus zinc finger protein 0.0029 0.0097 0.0097
Plasmodium falciparum glutathione reductase 0.0048 0.0227 0.8681
Echinococcus granulosus CREB binding protein 0.0018 0.0018 0.0016
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0165 0.0392
Toxoplasma gondii exonuclease III APE 0.0019 0.003 0.0407
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0324 0.0329
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0234 0.0237
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0099 0.0099
Leishmania major succinate dehydrogenase flavoprotein, putative 0.0022 0.0051 0.0242
Brugia malayi Thiosulfate sulfurtransferase D2023.5 0.0016 0.0005 0.0014
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0227 0.0233
Giardia lamblia Ribonuclease H 0.0027 0.008 0.0183
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0053 0.025
Echinococcus multilocularis dnaJ subfamily B 0.0855 0.576 0.5883
Mycobacterium tuberculosis Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) 0.0019 0.0028 0.0027
Schistosoma mansoni hypothetical protein 0.0028 0.0089 0.0089
Plasmodium falciparum flavoprotein subunit of succinate dehydrogenase 0.0022 0.0051 0.1796
Onchocerca volvulus 0.0049 0.0234 0.4104
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0078 0.0431 0.1977
Echinococcus granulosus bloom syndrome protein 0.0042 0.0188 0.019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0044 0.0043
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.008 0.0079
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0044 0.0043
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0027 0.008 0.2917
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0593 0.2725
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0338 0.0343
Schistosoma mansoni phosphoglucomutase 0.0027 0.008 0.008
Schistosoma mansoni hypothetical protein 0.01 0.0583 0.0594
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0005 0.0015
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0011 0.0043
Echinococcus multilocularis dual specificity mitogen activated protein 0.0079 0.0439 0.0447
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0049 0.023 0.0225
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.003 0.0028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0361 0.0367
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0165 0.0392
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.003 0.0061
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0044 0.0192
Schistosoma mansoni jumonji/arid domain-containing protein 0.0068 0.0361 0.0367
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0002 0.0005
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0053 0.186
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0017 0.0016
Echinococcus granulosus neuropeptide s receptor 0.0477 0.3166 0.3233
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0035 0.0134 0.1832
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0044 0.0043
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0188 0.0448
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1049 0.107
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.027 0.1322
Echinococcus multilocularis expressed conserved protein 0.0095 0.0551 0.0561
Brugia malayi RNase H family protein 0.0027 0.008 0.0359
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0023 0.0053 0.0048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0053 0.025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0611 0.4086 1
Leishmania major metacaspase, putative 0.0047 0.0218 0.1065
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0047 0.0218 0.0522
Trichomonas vaginalis STE family protein kinase 0.0079 0.0439 0.1064
Schistosoma mansoni caspase-3 (C14 family) 0.0124 0.0746 0.0761
Loa Loa (eye worm) succinate-ubiquinone oxidoreductase 0.0022 0.0051 0.0226
Schistosoma mansoni hypothetical protein 0.0042 0.0185 0.0187
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0137 0.014
Echinococcus granulosus hypothetical protein 0.0028 0.0089 0.0089
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.027 0.3695
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0011 0.0009
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.008 0.0383
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0044 0.0192
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0113 0.0675 0.0688
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0044 0.0043
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0196 0.0198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0044 0.0192
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0314 0.0322
Trypanosoma cruzi As/Sb Reductase, putative 0.0016 0.0005 0.0015
Mycobacterium leprae Probable succinate dehydrogenase (iron-sulfur protein subunit) SdhB (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHY 0.0029 0.0098 0.0093
Loa Loa (eye worm) hypothetical protein 0.0044 0.0196 0.0895
Leishmania major hypothetical protein, unknown function 0.0016 0.0005 0.0015
Brugia malayi hypothetical protein 0.0044 0.0201 0.0917
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0099 0.0099
Brugia malayi Rhodanese-like domain containing protein 0.0016 0.0005 0.0014
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.072 0.0715

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.001 uM Tested for the inhibition of wild type HIV-1 (IIIB) replication in MT-4 cells ChEMBL. 8863804
ED50 (functional) = 0.001 uM Tested for the inhibition of wild type HIV-1 (IIIB) replication in MT-4 cells ChEMBL. 8863804
ED50 (functional) = 0.03 uM Inhibition of mutant type (Cys181) HIV-1 (IIIB) replication in MT-4 cells ChEMBL. 8863804
ED50 (functional) = 0.03 uM Inhibition of mutant type (Cys181) HIV-1 (IIIB) replication in MT-4 cells ChEMBL. 8863804
ED50 (functional) = 0.2 uM Inhibition of mutant type (Ile100) HIV-1 (IIIB) replication in MT-4 cells ChEMBL. 8863804
ED50 (functional) = 0.2 uM Inhibition of mutant type (Ile100) HIV-1 (IIIB) replication in MT-4 cells ChEMBL. 8863804
IC50 (binding) = 0.003 uM Tested for the inhibition of wild type HIV-1 (IIIB) RT ChEMBL. 8863804
IC50 (binding) = 0.003 uM Tested for the inhibition of wild type HIV-1 (IIIB) RT ChEMBL. 8863804
IC50 (binding) = 0.05 uM Tested for the inhibition of mutant type (Cys181) HIV-1 (IIIB) RT ChEMBL. 8863804
IC50 (binding) = 0.05 uM Tested for the inhibition of mutant type (Cys181) HIV-1 (IIIB) RT ChEMBL. 8863804
IC50 (binding) = 0.06 uM Tested for the inhibition of mutant type (Ile100) HIV-1 (IIIB) RT ChEMBL. 8863804
IC50 (binding) = 0.06 uM Tested for the inhibition of mutant type (Ile100) HIV-1 (IIIB) RT ChEMBL. 8863804

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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