Detailed information for compound 233954

Basic information

Technical information
  • TDR Targets ID: 233954
  • Name: 2-[[4-(6-methylidene-2-oxooxan-3-yl)phenyl]me thyl]guanidine
  • MW: 259.304 | Formula: C14H17N3O2
  • H donors: 2 H acceptors: 1 LogP: 1.27 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)NCc1ccc(cc1)C1CCC(=C)OC1=O
  • InChi: 1S/C14H17N3O2/c1-9-2-7-12(13(18)19-9)11-5-3-10(4-6-11)8-17-14(15)16/h3-6,12H,1-2,7-8H2,(H4,15,16,17)
  • InChiKey: UMOBBFIXDWSJPG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-(6-methylene-2-oxo-tetrahydropyran-3-yl)phenyl]methyl]guanidine
  • 2-[[4-(6-methylene-2-oxo-3-tetrahydropyranyl)phenyl]methyl]guanidine
  • 2-[[4-(6-methylidene-2-oxo-oxan-3-yl)phenyl]methyl]guanidine
  • 2-[4-(2-keto-6-methylene-tetrahydropyran-3-yl)benzyl]guanidine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens plasminogen activator, urokinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus Mastin plasminogen activator, urokinase 414 aa 340 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase kappa 0.0021 0.021 0.021
Trypanosoma brucei unspecified product 0.0015 0.0121 0.0423
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.021 0.0769
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.007 0.0099
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.021 0.0769
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0525 0.7044 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.021 0.0769
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0162 0.023
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0007 0.0015 0.0016
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0014 0.0109 0.0604
Loa Loa (eye worm) hypothetical protein 0.0029 0.0316 0.0448
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0007 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.007 0.0099
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.021 0.0769
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.007 0.0099
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0379 0.5063 1
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0461 0.0729
Brugia malayi Pre-SET motif family protein 0.0408 0.5452 0.774
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.007 0.007
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0089 0.1131 0.5776
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0014 0.0109 0.0154
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0154
Schistosoma mansoni nuclear hormone receptor 0.0011 0.007 0.007
Echinococcus granulosus lamin 0.0029 0.0316 0.0316
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1244 0.1991
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0089 0.1131 0.1131
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0461 0.1743
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0014 0.0109 0.0361
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0089 0.1131 1
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0007 0.0015 0.0015
Brugia malayi MH2 domain containing protein 0.0018 0.0162 0.023
Loa Loa (eye worm) aldehyde dehydrogenase 0.0007 0.0015 0.0022
Echinococcus multilocularis bloom syndrome protein 0.0026 0.028 0.028
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0052 0.0625 0.2375
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0046 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.2593 0.4164
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0052 0.0625 0.2375
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.007 0.0099
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0052 0.0625 0.3164
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0022
Echinococcus granulosus dna polymerase kappa 0.0021 0.021 0.021
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0014 0.0109 0.0161
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0007 0.0015 0.0022
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0405 0.0772
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0014 0.0109 0.0376
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0007 0.0015 0.0016
Treponema pallidum sodium- and chloride- dependent transporter 0.0525 0.7044 1
Brugia malayi Pre-SET motif family protein 0.0059 0.0722 0.1026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0605 0.0605
Onchocerca volvulus 0.0089 0.1131 0.1587
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0133 0.0189
Plasmodium falciparum cysteine repeat modular protein 1 0.0035 0.0403 0.202
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.021 0.0386
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0678 0.3438
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0605 0.0605
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0306 0.0434
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.007 0.007
Echinococcus granulosus cpg binding protein 0.003 0.0327 0.0327
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0007 0.0015 0.0015
Plasmodium falciparum ferrodoxin reductase-like protein 0.0014 0.0109 0.0501
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0089 0.1131 0.1131
Trichomonas vaginalis apoptosis inducing factor, putative 0.0014 0.0109 0.0161
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0625 0.2375
Loa Loa (eye worm) hypothetical protein 0.0059 0.0722 0.1026
Echinococcus granulosus tissue type plasminogen activator 0.0035 0.0403 0.0403
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0014 0.0109 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.007 0.0099
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0014 0.0109 0.0604
Schistosoma mansoni DNA polymerase eta 0.0049 0.059 0.059
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.2593 0.2593
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.0029 0.0029
Plasmodium falciparum amino acid transporter, putative 0.0089 0.1131 0.5776
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0162 0.023
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.028 0.0437
Schistosoma mansoni kinase 0.01 0.128 0.128
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.059 0.2242
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0052 0.0625 0.3813
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0052 0.0625 0.2375
Schistosoma mansoni hypothetical protein 0.0007 0.0015 0.0015
Onchocerca volvulus 0.0029 0.0316 0.0427
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0197 0.2593 0.3682
Trichomonas vaginalis set domain proteins, putative 0.0464 0.6214 1
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0014 0.0109 0.0376
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.021 0.0769
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0014 0.0109 0.0184
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0099
Mycobacterium ulcerans hypothetical protein 0.0014 0.0109 0.0604
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0015 0.0015
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0007 0.0015 0.0022
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0007 0.0015 0.0025
Toxoplasma gondii hypothetical protein 0.0089 0.1131 0.5776
Leishmania major aldehyde dehydrogenase, putative 0.0007 0.0015 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.000000000098269
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0007 0.0015 0.0015
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.007 0.007
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0035 0.0403 0.0403
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0009 0.000000000098269
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.007 0.007
Loa Loa (eye worm) TK/ROR protein kinase 0.0035 0.0403 0.0572
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0237 0.1163
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.021 0.0769
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0014 0.0109 0.0109
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0014 0.0109 0.0376
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0052 0.0625 0.2375
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0461 0.0461
Plasmodium falciparum thioredoxin reductase 0.0149 0.195 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.007 0.007
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0029 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0625 0.2375
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.007 0.007
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0007 0.0015 0.0025
Onchocerca volvulus 0.0089 0.1131 0.1587
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0341 0.4547 0.8978
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0089 0.1131 0.1131
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0014 0.0109 0.0109
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0052 0.0625 0.2375
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0014 0.0109 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.007 0.0099
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0052 0.0625 0.5048
Echinococcus granulosus glutamate synthase 0.0014 0.0109 0.0109
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0007 0.0015 0.0016
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.021 0.0769
Entamoeba histolytica thioredoxin reductase, putative 0.0014 0.0109 0.0361
Schistosoma mansoni intermediate filament proteins 0.0029 0.0316 0.0316
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0014 0.0109 0.0376
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.162 0.162
Leishmania major hypothetical protein, conserved 0.0014 0.0109 0.0376
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0461 0.1743
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0014 0.0109 0.0376
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0625 0.2375
Toxoplasma gondii selenide, water dikinase 0.0014 0.0109 0.0501
Plasmodium falciparum glutathione reductase 0.0052 0.0625 0.3164
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0685 0.0685
Schistosoma mansoni hypothetical protein 0.0533 0.7158 0.7158
Brugia malayi polk-prov protein 0.0007 0.0011 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.007 0.0099
Entamoeba histolytica hypothetical protein 0.0075 0.0933 0.356
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.007 0.007
Brugia malayi steroid hormone receptor 0.0011 0.007 0.0099
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.007 0.0099
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0014 0.0109 0.0604
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.162 0.8297
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0316 0.0448
Echinococcus multilocularis lamin dm0 0.0029 0.0316 0.0316
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0007 0.0015 0.0025
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0052 0.0625 0.0625
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0015 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0605 0.0605
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.162 1
Giardia lamblia Kinase, PLK 0.0197 0.2593 1
Onchocerca volvulus 0.0029 0.0316 0.0427
Plasmodium vivax glutathione reductase, putative 0.0149 0.195 1
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0011 0.0011
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0052 0.0625 0.0625
Brugia malayi MH2 domain containing protein 0.026 0.3447 0.4894
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0525 0.7044 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0052 0.0625 0.0887
Loa Loa (eye worm) glutathione reductase 0.0149 0.195 0.2768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0605 0.0858
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0014 0.0109 0.0361
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0014 0.0109 0.0109
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0605 0.0605
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.007 0.0099
Trypanosoma brucei trypanothione reductase 0.0149 0.195 0.7508
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.007 0.0099
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0089 0.1131 0.1606
Mycobacterium ulcerans aldehyde dehydrogenase 0.0007 0.0015 0.0025
Loa Loa (eye worm) thioredoxin reductase 0.0149 0.195 0.2768
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0008 0.0029 0.002
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0007 0.0015 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.007 0.0099
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0392 0.1473
Leishmania major aldehyde dehydrogenase, putative 0.0007 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0055 0.0078
Mycobacterium tuberculosis Probable dehydrogenase 0.0341 0.4547 0.8978
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0007 0.0015 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.007 0.0099
Onchocerca volvulus 0.0464 0.6214 0.882
Plasmodium falciparum thioredoxin reductase 0.0052 0.0625 0.3164
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.007 0.0099
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0722 0.0722
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0038 0.0438 0.0622
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.021 0.0298
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0014 0.0109 0.0376
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.162 0.162
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.2593 0.4164
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.021 0.0386
Loa Loa (eye worm) nuclear factor I 0.001 0.0055 0.0078
Trypanosoma brucei NADH dehydrogenase 0.0014 0.0109 0.0376
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0014 0.0109 0.0361
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0933 0.0933
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0408 0.5452 0.774
Trichomonas vaginalis mercuric reductase, putative 0.0052 0.0625 0.0992
Toxoplasma gondii kringle domain-containing protein 0.0035 0.0403 0.202
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.2593 0.4164
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0007 0.0015 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.021 0.0769
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0112 0.0112
Brugia malayi Kringle domain containing protein 0.0035 0.0403 0.0572
Loa Loa (eye worm) hypothetical protein 0.0013 0.0105 0.0149
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.007 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0403 0.1517
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0089 0.1131 0.1131
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0007 0.0015 0.0025
Loa Loa (eye worm) Smad1 0.0018 0.0162 0.023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0309 0.0438
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0007 0.0015 0.0025
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.021 0.0755
Schistosoma mansoni thyroid hormone receptor 0.0011 0.007 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.021 0.0769
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.007 0.0227
Loa Loa (eye worm) RecQ helicase 0.0026 0.028 0.0398
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0014 0.0109 0.1528
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.007 0.007
Schistosoma mansoni sodium/chloride dependent transporter 0.0525 0.7044 0.7044
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0099
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.007 0.007
Echinococcus granulosus thioredoxin glutathione reductase 0.0149 0.195 0.195
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0007 0.0015 0.0016
Entamoeba histolytica hypothetical protein 0.0075 0.0933 0.356
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.000000000098269
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0341 0.4547 0.8978
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.007 0.007
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0046 0.0046
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0014 0.0109 0.0184
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0029 0.0042
Brugia malayi hypothetical protein 0.0075 0.0933 0.1325
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0007 0.0015 0.0015
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0014 0.0109 0.0604
Mycobacterium tuberculosis Probable oxidoreductase 0.0379 0.5063 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.007 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.007 0.0099
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0089 0.1131 0.1606
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0007 0.0015 0.0016
Leishmania major DNA polymerase eta, putative 0.0035 0.0392 0.1473
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0722 0.0722
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0007 0.0015 0.0016
Brugia malayi MH1 domain containing protein 0.0018 0.0162 0.023
Trichomonas vaginalis glutamate synthase, putative 0.0014 0.0109 0.0161
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0014 0.0109 0.0154
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0022
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0052 0.0625 1
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.007 0.007
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0007 0.0015 0.0021
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.028 0.0398
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0121 0.0423
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0722 0.3668
Schistosoma mansoni Smad4 0.0008 0.0029 0.0029
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0035 0.0403 0.202
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.000000000098269
Schistosoma mansoni smad1 5 8 and 0.0018 0.0162 0.0162
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0014 0.0109 0.0376
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0089 0.1131 0.1131
Echinococcus granulosus sodium and chloride dependent glycine 0.0089 0.1131 0.1131
Giardia lamblia Alcohol dehydrogenase 0.0007 0.0015 0.0016
Schistosoma mansoni smad1 5 8 and 0.0018 0.0162 0.0162
Schistosoma mansoni inositol monophosphatase 0.004 0.0461 0.0461
Loa Loa (eye worm) serotonin transporter b 0.0525 0.7044 1
Schistosoma mansoni sodium/chloride dependent transporter 0.009 0.114 0.114
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0007 0.0015 0.0021
Plasmodium falciparum glutathione reductase 0.0149 0.195 1
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0461 0.0461
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.021 0.021
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0007 0.0015 0.0022
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0089 0.1131 0.1131
Schistosoma mansoni Smad4 0.0018 0.0162 0.0162
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0014 0.0109 0.0184
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0405 0.0772
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.007 0.007
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0113 0.0395
Echinococcus granulosus intermediate filament protein 0.0029 0.0316 0.0316
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.000000000098269
Entamoeba histolytica hypothetical protein 0.0075 0.0933 0.356
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.007 0.007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.007 0.007
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0014 0.0109 0.0184
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0605 0.0605
Leishmania major aldehyde dehydrogenase, putative 0.0007 0.0015 0.0016
Trypanosoma cruzi NADH dehydrogenase, putative 0.0014 0.0109 0.0376
Echinococcus multilocularis microtubule associated protein 2 0.0743 1 1
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0007 0.0015 0.0016
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0014 0.0109 0.0161
Loa Loa (eye worm) norepinephrine transporter 0.0525 0.7044 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0052 0.0625 0.3813
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0316 0.0448
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.007 0.007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0605 0.0605
Brugia malayi Thioredoxin reductase 0.0149 0.195 0.2768
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0197 0.2593 0.2593
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.007 0.007
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.021 0.021
Leishmania major DNA polymerase kappa, putative 0.0021 0.021 0.0769
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0722 0.0722
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.007 0.0099
Loa Loa (eye worm) programmed cell death 8 0.0014 0.0109 0.0154
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0014 0.0109 0.0184
Loa Loa (eye worm) hypothetical protein 0.0089 0.1131 0.1606
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0007 0.0015 0.0022
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0046 0.0046
Schistosoma mansoni sodium/chloride dependent transporter 0.0089 0.1131 0.1131
Loa Loa (eye worm) hypothetical protein 0.0089 0.1131 0.1606
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0099
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0014 0.0109 0.0154
Trypanosoma brucei unspecified product 0.0021 0.021 0.0769
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.162 0.6229
Mycobacterium ulcerans monoxygenase 0.0014 0.0109 0.0604
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0765 0.0765
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.021 0.021
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0014 0.0109 0.0161
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0014 0.0109 0.0161
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0341 0.4547 0.8978
Onchocerca volvulus 0.0011 0.007 0.0077
Schistosoma mansoni glutamate synthase 0.0014 0.0109 0.0109
Echinococcus multilocularis lamin 0.0029 0.0316 0.0316
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0379 0.5063 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.021 0.0769
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0605 0.0605
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.007 0.0302
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0089 0.1131 0.1131
Echinococcus multilocularis cpg binding protein 0.003 0.0327 0.0327
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0089 0.1131 0.1606
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0014 0.0109 0.0161
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0007 0.0015 0.0016
Echinococcus multilocularis sodium and chloride dependent glycine 0.0089 0.1131 0.1131
Onchocerca volvulus Serine\/threonine kinase homolog 0.0197 0.2593 0.3668
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.2593 0.4164
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.021 0.0769
Plasmodium vivax ferrodoxin reductase, putative 0.0014 0.0109 0.0501
Schistosoma mansoni glutamate synthase 0.0014 0.0109 0.0109
Leishmania major hypothetical protein, conserved 0.0035 0.0403 0.1517
Echinococcus multilocularis geminin 0.0533 0.7158 0.7158
Schistosoma mansoni thyroid hormone receptor 0.0011 0.007 0.007
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0007 0.0015 0.0025
Leishmania major DNA polymerase eta, putative 0.0049 0.059 0.2242
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0014 0.0109 0.0161
Trypanosoma cruzi NADH dehydrogenase, putative 0.0014 0.0109 0.0376
Onchocerca volvulus 0.0059 0.0722 0.1006
Echinococcus multilocularis smad 0.0018 0.0162 0.0162
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0052 0.0625 0.0625
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.2593 0.4164
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0014 0.0109 0.0501
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.021 0.0769
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0007 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0159
Schistosoma mansoni sodium-dependent amino acid transporter 0.0089 0.1131 0.1131
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.007 0.007
Onchocerca volvulus 0.0525 0.7044 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.162 1
Schistosoma mansoni sulfide quinone reductase 0.0014 0.0109 0.0109
Toxoplasma gondii NADPH-glutathione reductase 0.0052 0.0625 0.3164
Schistosoma mansoni microtubule-associated protein tau 0.0743 1 1
Toxoplasma gondii thioredoxin reductase 0.0149 0.195 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0933 0.0933
Loa Loa (eye worm) hypothetical protein 0.0089 0.1131 0.1606
Trichomonas vaginalis glutamate synthase, putative 0.0014 0.0109 0.0161
Trypanosoma cruzi polo-like protein kinase, putative 0.0197 0.2593 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.021 0.0769
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0109 0.0376
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0162 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.007 0.0099
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0052 0.0625 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0014 0.0109 0.0501
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0161 0.0774
Schistosoma mansoni hypothetical protein 0.0533 0.7158 0.7158
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0014 0.0109 0.0501
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.000000000098269
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0007 0.0015 0.0016
Schistosoma mansoni smad 0.0018 0.0162 0.0162
Trichomonas vaginalis glutathione reductase, putative 0.0052 0.0625 0.0992
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0109 0.0376
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0014 0.0109 0.0109
Echinococcus multilocularis Smad4 0.0018 0.0162 0.0162
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.021 0.0324
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.007 0.007
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0007 0.0015 0.0025
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0007 0.0015 0.0016
Onchocerca volvulus 0.0014 0.0109 0.0132
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.007 0.007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.007 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0121 0.0423
Schistosoma mansoni smad 0.0008 0.0029 0.0029
Brugia malayi MH2 domain containing protein 0.0018 0.0162 0.023
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0089 0.1131 0.1131
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0525 0.7044 0.7044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.007 0.0099
Loa Loa (eye worm) MH2 domain-containing protein 0.026 0.3447 0.4894
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0007 0.0015 0.0021
Leishmania major hypothetical protein, conserved 0.0014 0.0109 0.0376
Giardia lamblia Glutamate synthase 0.0014 0.0109 0.0376
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0014 0.0109 0.0161
Mycobacterium tuberculosis Probable reductase 0.0341 0.4547 0.8978
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0113 0.0395
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0007 0.0015 0.0016
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0089 0.1131 0.1131
Echinococcus granulosus FTZ F1 alpha 0.0011 0.007 0.007
Echinococcus granulosus serotonin transporter 0.0525 0.7044 0.7044
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0052 0.0625 0.2375
Schistosoma mansoni cpg binding protein 0.003 0.0327 0.0327
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.007 0.007
Echinococcus granulosus dna polymerase eta 0.0049 0.059 0.059
Echinococcus granulosus bloom syndrome protein 0.0026 0.028 0.028
Mycobacterium ulcerans ferredoxin reductase 0.0014 0.0109 0.0604
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.021 0.0769
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0089 0.1131 0.1131
Loa Loa (eye worm) hypothetical protein 0.0525 0.7044 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0099
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0089 0.1131 0.1131
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.007 0.007
Brugia malayi Aldehyde dehydrogenase protein 4 0.0007 0.0015 0.0022
Plasmodium vivax SET domain protein, putative 0.0059 0.0722 0.3668
Echinococcus multilocularis sodium and chloride dependent glycine 0.0089 0.1131 0.1131
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.007 0.0099
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0162 0.0162
Onchocerca volvulus 0.0028 0.0306 0.0413
Loa Loa (eye worm) hypothetical protein 0.0089 0.1131 0.1606
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0052 0.0625 0.2375
Echinococcus granulosus sodium and chloride dependent glycine 0.0089 0.1131 0.1131
Giardia lamblia DINP protein human, muc B family 0.0021 0.021 0.0769
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0461 0.7321
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0105 0.0149
Trypanosoma cruzi trypanothione reductase, putative 0.0149 0.195 0.7508
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0014 0.0109 0.1528
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0099
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0015 0.0015
Onchocerca volvulus 0.0035 0.0403 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.007 0.0099
Treponema pallidum oxidoreductase 0.0014 0.0109 0.0132
Schistosoma mansoni DNA helicase recq5 0.0011 0.007 0.007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0625 0.2375
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0014 0.0109 0.0109
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0014 0.0109 0.0501
Echinococcus multilocularis thioredoxin glutathione reductase 0.0149 0.195 0.195
Leishmania major trypanothione reductase 0.0149 0.195 0.7508
Brugia malayi Protein kinase domain containing protein 0.0035 0.0403 0.0572
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0014 0.0109 0.0109
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.007 0.0302
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0014 0.0109 0.0361
Brugia malayi glutamate synthase 0.0014 0.0109 0.0154
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0014 0.0109 0.0501
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0052 0.0625 0.3164
Schistosoma mansoni hypothetical protein 0.0014 0.0109 0.0109
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0461 0.0729
Schistosoma mansoni lamin 0.0029 0.0316 0.0316
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0014 0.0109 0.0376
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.0029 0.0029
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.007 0.0077
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.028 0.0437
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0014 0.0109 0.0109
Brugia malayi serine/threonine-protein kinase plk-2 0.0197 0.2593 0.3682
Loa Loa (eye worm) hypothetical protein 0.0008 0.0029 0.0042
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0007 0.0015 0.0011
Treponema pallidum thioredoxin reductase (trxB) 0.0014 0.0109 0.0132
Loa Loa (eye worm) hypothetical protein 0.0089 0.1131 0.1606
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.021 0.0769
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0007 0.0015 0.0016
Mycobacterium ulcerans glutamate synthase subunit beta 0.0014 0.0109 0.0604
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0014 0.0109 0.0501
Loa Loa (eye worm) hypothetical protein 0.0049 0.059 0.0838
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.007 0.0099
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0197 0.2593 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.021 0.0769
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.007 0.007
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0007 0.0015 0.0021
Giardia lamblia Thioredoxin reductase 0.0014 0.0109 0.0376
Schistosoma mansoni disulfide oxidoreductase 0.0014 0.0109 0.0109
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0625 0.2375
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0014 0.0109 0.0501
Brugia malayi CXXC zinc finger family protein 0.0028 0.0306 0.0434
Brugia malayi MH1 domain containing protein 0.001 0.0055 0.0078
Echinococcus multilocularis tissue type plasminogen activator 0.0035 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0099
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.007 0.007
Leishmania major NADH dehydrogenase, putative 0.0014 0.0109 0.0376
Schistosoma mansoni coup transcription factor 0.0011 0.007 0.007
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0164 0.0789
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.007 0.007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0052 0.0625 0.2375
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0014 0.0109 0.0361
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0007 0.0015 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.007 0.0099
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0014 0.0109 0.0109
Brugia malayi aldehyde dehydrogenase 0.0007 0.0015 0.0022
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0007 0.0015 0.0016
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0007 0.0015 0.0016
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0014 0.0109 0.0376
Schistosoma mansoni Smad4 0.0008 0.0029 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0722 0.0722
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.021 0.1235
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0113 0.038
Plasmodium falciparum transporter, putative 0.0089 0.1131 0.5776
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0933 0.0933
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0014 0.0109 0.0109
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0068 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.007 0.0099
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0052 0.0625 0.2375
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.007 0.0099
Loa Loa (eye worm) hypothetical protein 0.0089 0.1131 0.1606
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0089 0.1131 0.1606
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.162 0.162
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0014 0.0109 0.0376
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.021 0.0769
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0014 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0133 0.1725 0.245
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.007 0.007
Schistosoma mansoni cpg binding protein 0.003 0.0327 0.0327
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.0029 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0121 0.0423
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0089 0.1131 0.1131
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0722 0.0722
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0014 0.0109 0.0501
Plasmodium vivax thioredoxin reductase, putative 0.0149 0.195 1
Brugia malayi MH1 domain containing protein 0.0018 0.0162 0.023
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.007 0.007
Schistosoma mansoni DNA helicase recq1 0.0011 0.007 0.007
Onchocerca volvulus 0.0089 0.1131 0.1587
Echinococcus multilocularis glutamate synthase 0.0014 0.0109 0.0109
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0014 0.0109 0.0161
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0014 0.0109 0.0604
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0014 0.0109 0.0109
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0007 0.0015 0.0025
Trypanosoma brucei polo-like protein kinase 0.0197 0.2593 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0089 0.1131 0.5776
Brugia malayi hypothetical protein 0.0089 0.1131 0.1606
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0052 0.0625 0.3164
Trypanosoma brucei unspecified product 0.0015 0.0121 0.0423
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.021 0.0324
Leishmania major hypothetical protein, conserved 0.0014 0.0109 0.0376
Loa Loa (eye worm) inositol-1 0.004 0.0461 0.0655
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0014 0.0109 0.0184
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.162 0.162
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0089 0.1131 0.1606
Echinococcus granulosus Smad4 0.0018 0.0162 0.0162
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.007 0.0077
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0625 0.2375
Brugia malayi ecdysteroid receptor 0.0011 0.007 0.0099
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0089 0.1131 0.1131
Loa Loa (eye worm) hypothetical protein 0.0525 0.7044 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1244 0.1991
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0009 0.000000000098269
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0112 0.0112
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0113 0.0168
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0046 0.0046
Echinococcus granulosus lamin dm0 0.0029 0.0316 0.0316
Echinococcus multilocularis dna polymerase eta 0.0049 0.059 0.059
Echinococcus multilocularis musashi 0.0029 0.0316 0.0316
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.007 0.0302
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0722 0.0722
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0052 0.0625 0.3813
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0162 0.0162
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.007 0.0099
Schistosoma mansoni inositol monophosphatase 0.004 0.0461 0.0461
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0625 0.2375
Mycobacterium ulcerans NADH dehydrogenase 0.0014 0.0109 0.0604
Loa Loa (eye worm) hypothetical protein 0.0035 0.0403 0.0572
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0379 0.5063 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.007 0.007
Mycobacterium ulcerans dehydrogenase 0.0014 0.0109 0.0604
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0014 0.0109 0.0184
Brugia malayi MH1 domain containing protein 0.001 0.0055 0.0078
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0089 0.1131 0.1606
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0052 0.0625 0.2375
Loa Loa (eye worm) transcription factor SMAD2 0.026 0.3447 0.4894
Entamoeba histolytica disulphide oxidoreductase, putative 0.0014 0.0109 0.0361
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0149 0.195 0.3832
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0014 0.0109 0.0376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.007 0.0099
Entamoeba histolytica hypothetical protein 0.0075 0.0933 0.356
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0007 0.0015 0.0016
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0014 0.0109 0.0184
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0162 0.0162
Brugia malayi nuclear hormone receptor 0.0011 0.007 0.0099
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0007 0.0015 0.0016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.007 0.007
Echinococcus multilocularis serotonin transporter 0.0525 0.7044 0.7044
Schistosoma mansoni sulfide quinone reductase 0.0014 0.0109 0.0109
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.021 0.1235
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.059 0.0838
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0461 0.1743
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0113 0.0395
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0014 0.0109 0.0161
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0007 0.0015 0.0015
Loa Loa (eye worm) histone methyltransferase 0.0011 0.007 0.0099
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0605 0.0858
Trypanosoma cruzi polo-like protein kinase, putative 0.0197 0.2593 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0461 0.1743
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0046 0.0046
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.021 0.0769
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0052 0.0625 0.1207
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0461 0.0729
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.2593 0.4164
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.007 0.0099
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0316 0.0448
Plasmodium vivax hypothetical protein, conserved 0.0089 0.1131 0.5776
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0014 0.0109 0.0154
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0109 0.0376
Schistosoma mansoni cpg binding protein 0.0028 0.0306 0.0306
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.059 0.2242
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0162 0.0162
Brugia malayi mothers against decapentaplegic homolog 3 0.0008 0.0029 0.0042
Brugia malayi MH2 domain containing protein 0.0008 0.0029 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0099
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0089 0.1131 0.1131
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0007 0.0015 0.0016
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0014 0.0109 0.0109
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0461 0.2798
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0461 0.173
Brugia malayi glutathione reductase 0.0149 0.195 0.2768
Brugia malayi intermediate filament protein 0.0029 0.0316 0.0448
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0089 0.1131 0.1606
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0007 0.0015 0.0015
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0089 0.1131 0.1131
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0007 0.0015 0.0015
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0007 0.0015 0.0025
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0009 0.000000000098269
Schistosoma mansoni hypothetical protein 0.0075 0.0933 0.0933
Giardia lamblia NADH oxidase lateral transfer candidate 0.0052 0.0625 0.2375
Toxoplasma gondii hypothetical protein 0.0089 0.1131 0.5776
Echinococcus granulosus smad 0.0018 0.0162 0.0162
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0392 0.1961
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0197 0.2593 0.2593
Brugia malayi Inositol-1 0.004 0.0461 0.0655
Brugia malayi nuclear receptor NHR-88 0.0011 0.007 0.0099
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.021 0.0298
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.2593 0.4164
Loa Loa (eye worm) hypothetical protein 0.0011 0.007 0.0099
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0052 0.0625 0.3164
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0038 0.0438 0.0622
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0006 0.0006
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.007 0.0077
Entamoeba histolytica serine/threonine protein kinase, putative 0.0197 0.2593 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.162 1
Plasmodium vivax amine transporter, putative 0.0089 0.1131 0.5776
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0007 0.0015 0.0025
Schistosoma mansoni aldehyde dehydrogenase 0.0007 0.0015 0.0015
Schistosoma mansoni lamin 0.0029 0.0316 0.0316
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0014 0.0109 0.1528
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0461 0.2322
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0014 0.0109 0.0184
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0014 0.0109 0.0501
Brugia malayi Smad1 0.0018 0.0162 0.023
Schistosoma mansoni glutamate synthase 0.0014 0.0109 0.0109
Echinococcus granulosus geminin 0.0533 0.7158 0.7158
Treponema pallidum NADH oxidase 0.0052 0.0625 0.0867
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0007 0.0015 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0722 0.0722
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.007 0.0099
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0014 0.0109 0.0184
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0341 0.4547 0.8978
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0089 0.1131 0.5776
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.162 0.3178
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0133 0.0189
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0341 0.4547 0.8978
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0014 0.0109 0.0604
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0007 0.0015 0.0016
Schistosoma mansoni smad1 5 8 and 0.0018 0.0162 0.0162
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0007 0.0015 0.0025
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0014 0.0109 0.0604
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0052 0.0625 0.3164
Loa Loa (eye worm) solute carrier family 6 member 4 0.0525 0.7044 1

Activities

Activity type Activity value Assay description Source Reference
Ka (binding) = 5.58 min-1 Compound was tested for the rate constant of acylation against the enzyme thrombin ChEMBL. 1447734
Ka (binding) = 5.58 min-1 Compound was tested for the rate constant of acylation against the enzyme thrombin ChEMBL. 1447734
ka (binding) = 5.58 min-1 Rate constant of acylation of the compound on thrombin was determined at 15 percent and at 94 minutes for maximum inhibition and no enzyme activity was recovered over the 2 h-time ChEMBL. No reference
Ka (binding) = 9.8 min-1 Compound was tested for the rate constant of acylation against the enzyme Urokinase-type plasminogen activator ChEMBL. 1447734
Ka (binding) = 9.8 min-1 Compound was tested for the rate constant of acylation against the enzyme Urokinase-type plasminogen activator ChEMBL. 1447734
ka (binding) = 9.8 min-1 Rate constant of acylation of the compound on Urokinase-type plasminogen activator elastase was determined at 0 percent and at 91 minutes for maximum inhibition and no enzyme activity was recovered over the 2 h-time ChEMBL. No reference
Ka (binding) = 57 min-1 Compound was tested for the rate constant of acylation against the enzyme plasmin ChEMBL. 1447734
Ka (binding) = 57 min-1 Compound was tested for the rate constant of acylation against the enzyme plasmin ChEMBL. 1447734
ka (binding) = 57 min-1 Rate constant of acylation of the compound on plasmin was determined at 30 percent and at 82 minutes for maximum inhibition and no enzyme activity was recovered over the 2 h-time ChEMBL. No reference
ka/Ki (binding) = 0.12 uM-1 min-1 Specificity constant of the compound on plasmin was determined at 30 percent and at 82 minutes for maximum inhibition and no enzyme activity was recovered over the 2 h-time ChEMBL. No reference
ka/Ki (binding) = 0.15 uM-1 min-1 Specificity constant of the compound on thrombin was determined at 15 percent and at 94 minutes for maximum inhibition and no enzyme activity was recovered over the 2 h-time ChEMBL. No reference
ka/Ki (binding) = 28 uM-1 min-1 Specificity constant of the compound on Urokinase-type plasminogen activator was determined at 0 percent and at 91 minutes for maximum inhibition and no enzyme activity was recovered over the 2 h-time ChEMBL. No reference
Kd (binding) min-1 Rate constant of deacylation of the compound was determined for plasmin; Fast and could not be measured ChEMBL. No reference
Kd (binding) fast 0 min-1 Compound was tested for the rate constant for deacylation against plasmin; kd was too fast to measure ChEMBL. 1447734
Kd (binding) = 0.006 min-1 Compound was tested for the rate constant of deacylation against thrombin ChEMBL. 1447734
Kd (binding) = 0.006 min-1 Compound was tested for the rate constant of deacylation against thrombin ChEMBL. 1447734
Kd (binding) = 0.006 min-1 Rate constant of deacylation of the compound was determined for thrombin ChEMBL. No reference
Kd (binding) = 0.044 min-1 Compound was tested for the rate constant of deacylation against the enzyme Urokinase-type plasminogen activator ChEMBL. 1447734
Kd (binding) = 0.044 min-1 Compound was tested for the rate constant of deacylation against the enzyme Urokinase-type plasminogen activator ChEMBL. 1447734
Kd (binding) = 0.044 min-1 Rate constant of deacylation of the compound was determined for Urokinase-type plasminogen activator ChEMBL. No reference
Ki (binding) = 0.35 uM Compound was tested for its binding affinity against the enzyme Urokinase-type plasminogen activator ChEMBL. 1447734
Ki (binding) = 0.35 uM Compound was tested for its binding affinity against the enzyme Urokinase-type plasminogen activator ChEMBL. 1447734
Ki (binding) = 37.87 uM Compound was tested for its binding affinity against the enzyme thrombin ChEMBL. 1447734
Ki (binding) = 37.87 uM Compound was tested for its binding affinity against the enzyme thrombin ChEMBL. 1447734
Ki (binding) = 466 uM Compound was tested for its binding affinity against the enzyme plasmin ChEMBL. 1447734
Ki (binding) = 466 uM Compound was tested for its binding affinity against the enzyme plasmin ChEMBL. 1447734
Ks/i (binding) = 0.35 uM Binding constant of the compound on Urokinase-type plasminogen activator was determined at 0 percent and at 91 minutes for maximum inhibition and no enzyme activity was recovered over the 2 h-time ChEMBL. No reference
Ks/i (binding) = 37.87 uM Binding constant of the compound on thrombin was determined at 15 percent and at 94 minutes for maximum inhibition and no enzyme activity was recovered over the 2 h-time ChEMBL. No reference
Ks/i (binding) = 466 uM Binding constant of the compound on plasmin was determined at 30 percent and at 82 minutes for maximum inhibition and no enzyme activity was recovered over the 2 h-time ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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