Detailed information for compound 251773

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 368.299 | Formula: C22H19Cl2N
  • H donors: 1 H acceptors: 0 LogP: 5.92 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1Cl)[C@@H]1C[C@@H](c2c1cccc2)NCc1ccccc1
  • InChi: 1S/C22H19Cl2N/c23-20-11-10-16(12-21(20)24)19-13-22(18-9-5-4-8-17(18)19)25-14-15-6-2-1-3-7-15/h1-12,19,22,25H,13-14H2/t19-,22-/m0/s1
  • InChiKey: FVVRXOHRSYEMTM-UGKGYDQZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 2 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 3 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 3 620 aa 579 aa 33.2 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 2 617 aa 638 aa 32.5 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) histone methyltransferase 0.0011 0.001 0.002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0157 0.0713 0.279
Trichomonas vaginalis ral, putative 0.0535 0.2544 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0238
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0009 0.0003
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0215
Onchocerca volvulus 0.0017 0.0035 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0112 0.0407
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0009 0.0003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1001 0.4798 1
Brugia malayi TAR-binding protein 0.0195 0.0899 0.3514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.045
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0234 0.0903
Brugia malayi mothers against decapentaplegic homolog 3 0.0016 0.003 0.0085
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0166 0.0635
Echinococcus multilocularis smad 0.0035 0.0123 0.0123
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0009 0.0009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0255 0.0255
Schistosoma mansoni cpg binding protein 0.0039 0.0142 0.0142
Onchocerca volvulus 0.0017 0.0035 0.0142
Mycobacterium tuberculosis Probable hydrolase 0.0157 0.0713 0.1173
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0215
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0168 0.1121
Schistosoma mansoni survival motor neuron protein 0.0047 0.0181 0.0181
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.045
Onchocerca volvulus 0.005 0.0195 0.0993
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0105
Trichomonas vaginalis esterase, putative 0.0157 0.0713 0.2778
Mycobacterium tuberculosis Conserved protein 0.0157 0.0713 0.1173
Echinococcus multilocularis serotonin transporter 0.0292 0.1367 0.1367
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1107 0.4333
Onchocerca volvulus 0.0017 0.0035 0.0142
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0157 0.0713 0.0713
Schistosoma mansoni cpg binding protein 0.0033 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Echinococcus multilocularis tar DNA binding protein 0.0195 0.0899 0.0899
Mycobacterium leprae conserved hypothetical protein 0.0157 0.0713 0.8441
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0035 0.0124 0.0455
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0672 0.4558
Echinococcus multilocularis lamin dm0 0.0058 0.0234 0.0234
Echinococcus granulosus transient receptor potential cation channel 0.0169 0.0773 0.0773
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0052 0.0205 0.284
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0166 0.0757 0.0757
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0195 0.0195
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0124 0.0557 0.0835
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0181 0.068
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.147 1
Schistosoma mansoni tar DNA-binding protein 0.0195 0.0899 0.0899
Loa Loa (eye worm) MH2 domain-containing protein 0.0511 0.2425 0.9534
Brugia malayi RNA recognition motif domain containing protein 0.0195 0.0899 0.3514
Brugia malayi RNA binding protein 0.0195 0.0899 0.3514
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0052 0.0205 0.0789
Plasmodium falciparum amino acid transporter, putative 0.005 0.0195 0.2868
Schistosoma mansoni tar DNA-binding protein 0.0195 0.0899 0.0899
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0052 0.0205 0.284
Trichomonas vaginalis dexras1, putative 0.0535 0.2544 1
Onchocerca volvulus 0.005 0.0195 0.0993
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0215 0.1439
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0009 0.0009
Schistosoma mansoni Smad4 0.0016 0.003 0.003
Brugia malayi AMP-binding enzyme family protein 0.0176 0.0807 0.3148
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0195 0.0899 0.3524
Mycobacterium ulcerans hypothetical protein 0.0157 0.0713 0.8441
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0009 0.0009
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.0734
Echinococcus multilocularis muscleblind protein 0.0171 0.0784 0.0784
Brugia malayi PHD-finger family protein 0.0051 0.02 0.0756
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0016
Mycobacterium tuberculosis Probable lipase LipE 0.0157 0.0713 0.1173
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0105
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0255 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0009 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0255 0.0986
Brugia malayi beta-lactamase 0.0157 0.0713 0.2778
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0035 0.012
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0132 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0592 0.2311
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0205 0.0775
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0016
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0009 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.0157 0.0713 0.2778
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0238
Loa Loa (eye worm) hypothetical protein 0.0196 0.0903 0.3539
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0466 0.2209 0.8681
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0052 0.0205 0.0205
Echinococcus granulosus cathepsin l1 0.0011 0.0009 0.0009
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0052 0.0205 0.1374
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0265 0.0265
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0043 0.0266
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.008 0.0281
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0105
Echinococcus multilocularis ras gtpase 0.0535 0.2544 0.2544
Schistosoma mansoni coup transcription factor 0.0011 0.0009 0.0009
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0009 0.0009
Schistosoma mansoni smad1 5 8 and 0.0035 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0112 0.0407
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0176 0.0807 1
Trypanosoma brucei hypothetical protein, conserved 0.0157 0.0713 0.4837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0166 0.0621
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0265 0.0265
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.005 0.0195 0.0195
Trypanosoma brucei ISWI complex protein 0.003 0.01 0.0658
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0119 0.053 0.053
Leishmania major cathepsin L-like protease 0.0063 0.0261 0.1752
Echinococcus granulosus beta LACTamase domain containing family member 0.0157 0.0713 0.0713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0026 0.0067
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0112 0.0407
Schistosoma mansoni bromodomain containing protein 0.001 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.045
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Schistosoma mansoni intermediate filament proteins 0.0058 0.0234 0.0234
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0398 0.1882 0.1882
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Loa Loa (eye worm) serotonin transporter b 0.0292 0.1367 0.5367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0166 0.0621
Onchocerca volvulus 0.0292 0.1367 0.7253
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0195 0.0195
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0195 0.0195
Brugia malayi Muscleblind-like protein 0.0171 0.0784 0.3058
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0124 0.0124
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0026 0.0151
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.001 0.001
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0398 0.1882 0.1882
Entamoeba histolytica hypothetical protein 0.0035 0.0124 0.0455
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0081 0.0286
Loa Loa (eye worm) Smad1 0.0035 0.0123 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0009 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Brugia malayi Ras-related protein R-Ras2 0.0535 0.2544 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0033 0.0117 0.0117
Echinococcus granulosus tumor protein p63 0.178 0.8566 0.8566
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0104 0.0378
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0157 0.0713 0.1173
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0123 0.0814
Onchocerca volvulus 0.0017 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0052 0.0205 0.0789
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0026 0.0151
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0195 0.0195
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0195 0.0195
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1063 0.1063
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0117 0.0117
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0052 0.0205 0.0075
Loa Loa (eye worm) transcription factor SMAD2 0.0511 0.2425 0.9534
Loa Loa (eye worm) hypothetical protein 0.0176 0.0807 0.3159
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0035 0.012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0009 0.0003
Echinococcus multilocularis dnaJ subfamily B 0.0469 0.2225 0.2225
Brugia malayi Bromodomain containing protein 0.0149 0.0675 0.263
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0166 0.0621
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0195 0.0195
Schistosoma mansoni cellular tumor antigen P53 0.0261 0.1215 0.1215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0081 0.0286
Leishmania major 4-coumarate:coa ligase-like protein 0.0176 0.0807 0.5476
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0052 0.0205 0.0075
Loa Loa (eye worm) oxidoreductase 0.0052 0.0205 0.0789
Leishmania major acetyl-CoA synthetase, putative 0.0052 0.0205 0.1374
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0166 0.0166
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0749
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.005 0.0195 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0168 0.1121
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0166 0.1107
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0215
Onchocerca volvulus 0.0017 0.0035 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0205 0.0775
Loa Loa (eye worm) cysteine protease 0.0017 0.0035 0.012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0298 0.0298
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0009 0.0003
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0035 0.0105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0035 0.0035
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1063 0.1063
Loa Loa (eye worm) PHD-finger family protein 0.004 0.0151 0.0575
Echinococcus multilocularis mothers against decapentaplegic 2 0.0016 0.003 0.003
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0215
Echinococcus granulosus mothers against decapentaplegic 6 0.0016 0.003 0.003
Giardia lamblia GTOR 0.0044 0.0166 0.5
Brugia malayi nuclear hormone receptor 0.0011 0.0009 0.0003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0168 0.1121
Onchocerca volvulus 0.0011 0.0009 0.0004
Schistosoma mansoni smad1 5 8 and 0.0035 0.0123 0.0123
Echinococcus multilocularis inhibitor of apoptosis protein 0.0398 0.1882 0.1882
Leishmania major mitochondrial DNA polymerase beta 0.0313 0.147 1
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0035 0.0035
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.0749
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0094 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0097 0.0347
Loa Loa (eye worm) hypothetical protein 0.0157 0.0713 0.279
Brugia malayi AMP-binding enzyme family protein 0.0176 0.0807 0.3148
Loa Loa (eye worm) hypothetical protein 0.0176 0.0807 0.3159
Leishmania major 4-coumarate:coa ligase-like protein 0.0176 0.0807 0.5476
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.005 0.0195 0.0734
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Loa Loa (eye worm) hypothetical protein 0.0134 0.0603 0.2357
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0255 0.0255
Entamoeba histolytica Ras family GTPase 0.0535 0.2544 1
Schistosoma mansoni hypothetical protein 0.0035 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Echinococcus multilocularis cysteine protease 0.0017 0.0035 0.0035
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0052 0.0205 0.1374
Brugia malayi MH2 domain containing protein 0.0035 0.0123 0.0452
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0009 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0009 0.0003
Loa Loa (eye worm) hypothetical protein 0.0292 0.1367 0.5367
Echinococcus granulosus fetal alzheimer antigen falz 0.0046 0.0178 0.0178
Echinococcus multilocularis microtubule associated protein 2 0.2077 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0196 0.0903 0.3528
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0009 0.0009
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0123 0.0123
Leishmania major hypothetical protein, conserved 0.003 0.01 0.0658
Toxoplasma gondii propionate-CoA ligase 0.0052 0.0205 0.284
Brugia malayi intermediate filament protein 0.0058 0.0234 0.0888
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0749
Onchocerca volvulus 0.0047 0.0181 0.092
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0026 0.0026
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0052 0.0205 0.0075
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0195 0.0195
Entamoeba histolytica cysteine protease, putative 0.0017 0.0035 0.0105
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0176 0.0807 0.1375
Echinococcus multilocularis ankyrin repeat protein 0.0166 0.0757 0.0757
Schistosoma mansoni lamin 0.0058 0.0234 0.0234
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0292 0.1367 0.536
Onchocerca volvulus 0.0017 0.0035 0.0142
Trichomonas vaginalis rotamase, putative 0.0033 0.0115 0.0419
Trichomonas vaginalis GTP-binding protein rit, putative 0.0535 0.2544 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0052 0.0205 0.1374
Schistosoma mansoni zinc finger protein 0.003 0.01 0.01
Entamoeba histolytica Ras family GTPase 0.0535 0.2544 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0176 0.0807 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0157 0.0713 0.0713
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0052 0.0205 0.0075
Onchocerca volvulus 0.0238 0.1107 0.5863
Brugia malayi nuclear receptor NHR-88 0.0011 0.0009 0.0003
Loa Loa (eye worm) hypothetical protein 0.0064 0.0265 0.1025
Onchocerca volvulus 0.0058 0.0234 0.1202
Loa Loa (eye worm) hypothetical protein 0.0398 0.1882 0.7394
Brugia malayi Calcitonin receptor-like protein seb-1 0.0196 0.0903 0.3528
Echinococcus granulosus muscleblind protein 0.0171 0.0784 0.0784
Brugia malayi latrophilin 2 splice variant baaae 0.0134 0.0603 0.2345
Onchocerca volvulus 0.0017 0.0035 0.0142
Brugia malayi beta-lactamase family protein 0.0157 0.0713 0.2778
Schistosoma mansoni hypothetical protein 0.0062 0.0255 0.0255
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.2694
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0112 0.1527
Echinococcus granulosus inhibitor of apoptosis protein 0.0398 0.1882 0.1882
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0176 0.0807 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0166 0.1107
Loa Loa (eye worm) hypothetical protein 0.0157 0.0713 0.279
Brugia malayi hypothetical protein 0.005 0.0195 0.0734
Echinococcus granulosus ankyrin repeat protein 0.0166 0.0757 0.0757
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0009 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0205 0.0775
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0255 0.0972
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0398 0.1882 0.7389
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0132 0.0592 0.6421
Loa Loa (eye worm) hypothetical protein 0.0052 0.0205 0.0789
Loa Loa (eye worm) hypothetical protein 0.0027 0.0085 0.0314
Echinococcus granulosus tar DNA binding protein 0.0195 0.0899 0.0899
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.012
Mycobacterium tuberculosis Conserved protein 0.0157 0.0713 0.1173
Schistosoma mansoni rotamase 0.0033 0.0115 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0009 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0176 0.0807 0.5476
Loa Loa (eye worm) TAR-binding protein 0.0195 0.0899 0.3524
Loa Loa (eye worm) Ras protein let-60 0.0535 0.2544 1
Echinococcus granulosus ras gtpase 0.0535 0.2544 0.2544
Loa Loa (eye worm) hypothetical protein 0.0157 0.0713 0.279
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0166 0.1107
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0261 0.1752
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0168 0.1121
Plasmodium falciparum transporter, putative 0.005 0.0195 0.2868
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0234 0.1571
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0052 0.0205 0.1374
Echinococcus multilocularis muscleblind protein 1 0.0171 0.0784 0.0784
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0016 0.003 0.0115
Schistosoma mansoni hypothetical protein 0.0469 0.2225 0.2225
Schistosoma mansoni hypothetical protein 0.003 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0292 0.1367 0.5367
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.0749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0009 0.0009
Echinococcus multilocularis zinc finger protein 0.004 0.015 0.015
Schistosoma mansoni microtubule-associated protein tau 0.2077 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0195 0.0899 0.0899
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0103 0.1404
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0123 0.0814
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0132 0.0592 0.2311
Brugia malayi follicle stimulating hormone receptor 0.0466 0.2209 0.8679
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0009 0.0009
Brugia malayi steroid hormone receptor 0.0011 0.0009 0.0003
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0195 0.0195
Loa Loa (eye worm) nuclear factor I 0.0019 0.0048 0.0171
Trichomonas vaginalis rap1 and, putative 0.0535 0.2544 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0261 0.1752
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0052 0.0205 0.3054
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0105
Plasmodium vivax acetyl-CoA synthetase, putative 0.0052 0.0205 0.2507
Schistosoma mansoni hypothetical protein 0.0062 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0028 0.009 0.0334
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0124 0.0557 0.0835
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0115 0.0434
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0157 0.0713 0.4837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0035 0.0035
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0052 0.0205 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0009 0.0009
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0195 0.0195
Brugia malayi MH2 domain containing protein 0.0035 0.0123 0.0452
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0062 0.0255 0.0986
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0124 0.0557 0.0835
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0035 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Plasmodium vivax amine transporter, putative 0.005 0.0195 0.2354
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0195 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Loa Loa (eye worm) hypothetical protein 0.0139 0.0626 0.2446
Leishmania major acetyl-CoA synthetase, putative 0.0052 0.0205 0.1374
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0123 0.0123
Echinococcus multilocularis transient receptor potential cation channel 0.0169 0.0773 0.0773
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0398 0.1882 0.7394
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0157 0.0713 0.279
Trichomonas vaginalis penicillin-binding protein, putative 0.0157 0.0713 0.2778
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0026 0.0151
Brugia malayi MH2 domain containing protein 0.0016 0.003 0.0085
Onchocerca volvulus 0.0157 0.0713 0.376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.045
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.0205 0.0775
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Mycobacterium ulcerans esterase/lipase LipP 0.0157 0.0713 0.8441
Onchocerca volvulus Deterin homolog 0.0398 0.1882 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0009 0.0018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0176 0.0807 0.3148
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0119 0.053 0.053
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0123 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0009 0.0018
Mycobacterium ulcerans lipase LipD 0.0157 0.0713 0.8441
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0009 0.0009
Schistosoma mansoni smad1 5 8 and 0.0035 0.0123 0.0123
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0195 0.0195
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0009 0.0004
Brugia malayi Smad1 0.0035 0.0123 0.0452
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0176 0.0807 0.1375
Schistosoma mansoni hypothetical protein 0.004 0.0151 0.0151
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0009 0.0009
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0195 0.0195
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0166 0.0166
Echinococcus granulosus zinc finger protein 0.004 0.015 0.015
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0009 0.0009
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0195 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0009 0.0003
Echinococcus granulosus lamin 0.0058 0.0234 0.0234
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0749
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0111 0.0733
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 0.1367 0.1367
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0166 0.1107
Echinococcus granulosus smad 0.0035 0.0123 0.0123
Plasmodium vivax SET domain protein, putative 0.0031 0.0103 0.1004
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0205 0.0075
Loa Loa (eye worm) RNA binding protein 0.0195 0.0899 0.3524
Onchocerca volvulus 0.0052 0.0205 0.1049
Schistosoma mansoni hypothetical protein 0.0062 0.0255 0.0255
Schistosoma mansoni acetyl-CoA synthetase 0.0052 0.0205 0.0205
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0157 0.0713 0.1173
Loa Loa (eye worm) hypothetical protein 0.0176 0.0807 0.3159
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0035 0.0105
Schistosoma mansoni inhibitor of apoptosis protein 0.0398 0.1882 0.1882
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0261 0.1752
Loa Loa (eye worm) hypothetical protein 0.0171 0.0784 0.3069
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0009 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0195 0.0899 0.0899
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0009 0.0009
Brugia malayi Pre-SET motif family protein 0.0031 0.0103 0.0373
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0052 0.0205 0.1374
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0009 0.0009
Mycobacterium ulcerans hypothetical protein 0.0165 0.0753 0.9108
Schistosoma mansoni cpg binding protein 0.0039 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0292 0.1367 0.5367
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0398 0.1882 0.1882
Schistosoma mansoni hypothetical protein 0.0062 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0085 0.0369 0.1433
Trichomonas vaginalis D-aminoacylase, putative 0.0157 0.0713 0.2778
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0749
Echinococcus multilocularis Smad4 0.0035 0.0123 0.0123
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0111 0.0404
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0132 0.0592 0.091
Schistosoma mansoni Smad4 0.0016 0.003 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0124 0.0124
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.005 0.0195 0.0195
Onchocerca volvulus 0.0058 0.0234 0.1202
Echinococcus multilocularis expressed protein 0.0033 0.0115 0.0115
Onchocerca volvulus 0.0031 0.0103 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0135 0.0499
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0234 0.0888
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0123 0.0467
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0046 0.0178 0.0178
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0052 0.0205 0.0789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0237
Brugia malayi hypothetical protein 0.0229 0.1063 0.416
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0115 0.0419
Toxoplasma gondii ABC1 family protein 0.0157 0.0713 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0035 0.0105
Echinococcus granulosus methyl CpG binding domain protein 2 0.0033 0.0117 0.0117
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0234 0.0903
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0052 0.0205 0.0075
Echinococcus granulosus dnaJ subfamily B 0.0469 0.2225 0.2225
Echinococcus granulosus intermediate filament protein 0.0058 0.0234 0.0234
Mycobacterium tuberculosis Conserved protein 0.0157 0.0713 0.1173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0081 0.0286
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0009 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0195 0.0899 0.0899
Echinococcus multilocularis mothers against decapentaplegic 6 0.0016 0.003 0.003
Mycobacterium leprae Probable lipase LipE 0.0157 0.0713 0.8441
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0117 0.0117
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.2694
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0009 0.0003
Brugia malayi Pre-SET motif family protein 0.0209 0.0968 0.3783
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0052 0.0205 0.0775
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0009 0.0004
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0883
Brugia malayi CXXC zinc finger family protein 0.0033 0.0114 0.0417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0009 0.0018
Echinococcus granulosus cpg binding protein 0.0039 0.0142 0.0142
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.147 1
Echinococcus granulosus expressed protein 0.0033 0.0115 0.0115
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0195 0.0195
Mycobacterium tuberculosis Probable esterase LipL 0.0157 0.0713 0.1173
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.0157 0.0713 0.279
Onchocerca volvulus 0.0052 0.0205 0.1049
Echinococcus granulosus serotonin transporter 0.0292 0.1367 0.1367
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0115 0.0419
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0052 0.0205 0.0075
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0009 0.0003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0157 0.0713 0.2778
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0035 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0166 0.0621
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.005 0.0195 0.0195
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.001 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0205 0.0075
Leishmania major cathepsin L-like protease 0.0063 0.0261 0.1752
Loa Loa (eye worm) hypothetical protein 0.0019 0.0048 0.0171
Schistosoma mansoni Smad4 0.0035 0.0123 0.0123
Echinococcus multilocularis cysteine protease 0.0017 0.0035 0.0035
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0123 0.045
Mycobacterium ulcerans beta-lactamase 0.0157 0.0713 0.8441
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0749
Entamoeba histolytica ras-1, putative 0.0535 0.2544 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0026 0.0067
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0195 0.1306
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0398 0.1882 0.7389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0052 0.0205 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0026 0.0067
Schistosoma mansoni hypothetical protein 0.0134 0.0603 0.0603
Plasmodium vivax hypothetical protein, conserved 0.0157 0.0713 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0195 0.0195
Schistosoma mansoni lamin 0.0058 0.0234 0.0234
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0009 0.0009
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0166 0.0621
Toxoplasma gondii hypothetical protein 0.0051 0.0199 0.2759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0035 0.0142
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0285 0.3962
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0027 0.0073
Mycobacterium ulcerans acyl-CoA synthetase 0.0176 0.0807 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0265 0.0265
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0111 0.0733
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0026 0.0026
Loa Loa (eye worm) beta-lactamase 0.0157 0.0713 0.279
Echinococcus multilocularis musashi 0.0058 0.0234 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0009 0.0003
Trichomonas vaginalis rheb, putative 0.0535 0.2544 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0261 0.1215 0.4769
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0009 0.0018
Onchocerca volvulus 0.0052 0.0205 0.1049
Echinococcus multilocularis tumor protein p63 0.178 0.8566 0.8566
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0296 0.0296
Onchocerca volvulus 0.0398 0.1882 1
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0261 0.1752
Trichomonas vaginalis antibiotic synthetase, putative 0.0052 0.0205 0.0775
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0205 0.0075
Onchocerca volvulus 0.0052 0.0205 0.1049
Schistosoma mansoni hypothetical protein 0.0398 0.1882 0.1882
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 0.1367 0.5367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0026 0.0067
Echinococcus granulosus Smad4 0.0035 0.0123 0.0123
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0176 0.0807 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0749
Onchocerca volvulus 0.005 0.0195 0.0993
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0103 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0112 0.0407
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0035 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Brugia malayi MH1 domain containing protein 0.0035 0.0123 0.0452
Mycobacterium ulcerans acyl-CoA synthetase 0.0176 0.0807 1
Leishmania major cathepsin L-like protease 0.0017 0.0035 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0112 0.0407
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0123 0.0467
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0111 0.0733
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0111 0.1516
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.0734
Entamoeba histolytica acyl-coA synthetase, putative 0.0176 0.0807 0.3148
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0296 0.0296
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0009 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0112 0.0407
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0166 0.1107
Brugia malayi Ras protein let-60 0.0535 0.2544 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.005 0.0195 0.0195
Brugia malayi hypothetical protein 0.0035 0.0124 0.0455
Loa Loa (eye worm) hypothetical protein 0.0229 0.1063 0.4169
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0026 0.0151
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0055 0.0349
Brugia malayi beta-lactamase family protein 0.0157 0.0713 0.2778
Loa Loa (eye worm) hypothetical protein 0.0027 0.0085 0.0314
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0052 0.0205 0.1374
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0157 0.0713 0.1173
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0026 0.0083
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0026 0.0151
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.001 0.0004 0.5
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0035 0.0035
Leishmania major cathepsin L-like protease 0.0063 0.0261 0.1752
Entamoeba histolytica acyl-CoA synthetase, putative 0.0176 0.0807 0.3148
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0035 0.0035
Loa Loa (eye worm) ctsf protein 0.0017 0.0035 0.012
Schistosoma mansoni smad 0.0035 0.0123 0.0123
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0535 0.2544 1
Plasmodium vivax hypothetical protein, conserved 0.005 0.0195 0.2354
Toxoplasma gondii hypothetical protein 0.005 0.0195 0.2694
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0012 0.0012
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0009 0.0009
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0009 0.0018
Plasmodium vivax acyl-CoA synthetase, putative 0.0132 0.0592 0.8207
Brugia malayi Bromodomain containing protein 0.0075 0.0318 0.1221
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0196 0.0903 0.3539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0238
Trichomonas vaginalis antibiotic synthetase, putative 0.0052 0.0205 0.0775
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.009 0.009
Brugia malayi ecdysteroid receptor 0.0011 0.0009 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0009 0.0009
Echinococcus granulosus cathepsin l1 0.0017 0.0035 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0157 0.0713 0.2778
Onchocerca volvulus 0.0261 0.1215 0.6442
Entamoeba histolytica hypothetical protein 0.0035 0.0124 0.0455
Loa Loa (eye worm) fibroinase 0.0017 0.0035 0.012
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0157 0.0713 0.8441
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0009 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0176 0.0807 1
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0205 0.0775
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Mycobacterium tuberculosis Probable lipase LipD 0.0157 0.0713 0.1173
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0046 0.0178 0.0178
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 0.1367 0.1367
Loa Loa (eye worm) norepinephrine transporter 0.0292 0.1367 0.5367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0009 0.0018
Loa Loa (eye worm) hypothetical protein 0.0132 0.0592 0.2311
Loa Loa (eye worm) hypothetical protein 0.0171 0.0784 0.3069
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0026 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0026 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0255 0.0972
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.0734
Echinococcus multilocularis lamin 0.0058 0.0234 0.0234
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Mycobacterium ulcerans hypothetical protein 0.0176 0.0807 1
Trichomonas vaginalis D-aminoacylase, putative 0.0157 0.0713 0.2778
Brugia malayi MH2 domain containing protein 0.0511 0.2425 0.9534
Schistosoma mansoni hypothetical protein 0.0047 0.0181 0.0181
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0104 0.0393
Loa Loa (eye worm) hypothetical protein 0.0132 0.0592 0.2311
Entamoeba histolytica hypothetical protein 0.0035 0.0124 0.0455
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0112 0.0407
Onchocerca volvulus 0.0157 0.0713 0.376
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0968 0.3793
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0255 0.0255
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0124 0.0124
Echinococcus granulosus mothers against decapentaplegic 2 0.0016 0.003 0.003
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0111 0.0733
Echinococcus granulosus GPCR family 2 0.0062 0.0255 0.0255
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0103 0.0103
Trypanosoma cruzi ISWI complex protein 0.003 0.01 0.0658
Toxoplasma gondii cathepsin CPL 0.0017 0.0035 0.0445
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0035 0.0035
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.0672 0.4558
Trichomonas vaginalis rotamase, putative 0.0032 0.0111 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0237
Trichomonas vaginalis ras-dva small GTPase, putative 0.0535 0.2544 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0166 0.0621
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0166 0.0166
Brugia malayi MH1 domain containing protein 0.0035 0.0123 0.0452
Loa Loa (eye worm) hypothetical protein 0.0132 0.0592 0.2311
Plasmodium falciparum acyl-CoA synthetase 0.0132 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Toxoplasma gondii hypothetical protein 0.005 0.0195 0.2694
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0166 0.1107
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0009 0.0009
Schistosoma mansoni zinc finger protein 0.004 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0176 0.0807 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0672 0.4558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.008 0.0281
Loa Loa (eye worm) hypothetical protein 0.008 0.0341 0.1326
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0114 0.0432
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0035 0.0215
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0009 0.0009
Echinococcus multilocularis GPCR, family 2 0.0062 0.0255 0.0255
Echinococcus granulosus lamin dm0 0.0058 0.0234 0.0234
Trypanosoma cruzi hypothetical protein, conserved 0.0157 0.0713 0.4837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0092 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0009 0.0003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0026 0.0067
Loa Loa (eye worm) hypothetical protein 0.0075 0.0319 0.1238
Brugia malayi AMP-binding enzyme family protein 0.0176 0.0807 0.3148
Loa Loa (eye worm) hypothetical protein 0.0157 0.0713 0.279
Loa Loa (eye worm) hypothetical protein 0.0058 0.0234 0.0903
Brugia malayi MH1 domain containing protein 0.0019 0.0048 0.0155
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0009 0.0009
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0123 0.0814
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.003 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0035 0.0105
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 0.1367 0.5
Schistosoma mansoni smad 0.0016 0.003 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0261 0.1752
Onchocerca volvulus 0.0157 0.0713 0.376
Brugia malayi Cathepsin L-like precursor 0.0017 0.0035 0.0105
Leishmania major hypothetical protein, conserved 0.0157 0.0713 0.4837
Schistosoma mansoni bromodomain containing protein 0.0126 0.0564 0.0564
Echinococcus multilocularis cpg binding protein 0.0039 0.0142 0.0142
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.0753 0.1259
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0052 0.0205 0.0775
Echinococcus multilocularis beta LACTamase domain containing family member 0.0157 0.0713 0.0713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0238
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0313 0.147 1
Onchocerca volvulus 0.0176 0.0807 0.4261
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0009 0.0009
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0035 0.0215
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0195 0.2694
Onchocerca volvulus 0.0033 0.0114 0.0564
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0205 0.0075
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0009 0.0018
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.005 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0124 0.0557 0.0835
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0052 0.0205 0.1374
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0176 0.0807 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0026 0.0026
Brugia malayi MH1 domain containing protein 0.0019 0.0048 0.0155
Loa Loa (eye worm) hypothetical protein 0.005 0.0195 0.0749
Trypanosoma cruzi ISWI complex protein 0.003 0.01 0.0658

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1100 nM Binding affinity against cloned human dopamine transporter using 40-80 pM [125I]-RTI. ChEMBL. 11150168
Ki (binding) = 1100 nM Binding affinity against cloned human dopamine transporter using 40-80 pM [125I]-RTI. ChEMBL. 11150168
Ki (binding) = 2100 nM Binding affinity against cloned serotonin human transporter using 40-80 PM [125I]-RTI ChEMBL. 11150168
Ki (binding) = 2100 nM Binding affinity against cloned serotonin human transporter using 40-80 PM [125I]-RTI ChEMBL. 11150168
Ki (binding) = 4800 nM Binding affinity against norepinephrine cloned human transporter using 40-80 pM [125I]-RTI ChEMBL. 11150168
Ki (binding) = 4800 nM Binding affinity against norepinephrine cloned human transporter using 40-80 pM [125I]-RTI ChEMBL. 11150168
Ki (binding) = 5300 nM Inhibition of reuptake of [3H]-DA (20 nM) by dopamine transporter ChEMBL. 11150168
Ki (binding) = 5300 nM Inhibition of reuptake of [3H]-DA (20 nM) by dopamine transporter ChEMBL. 11150168
Ki (binding) > 10 uM Inhibition of reuptake of [3H]-5-HT (20 nM) by serotonin transporter ChEMBL. 11150168
Ki (binding) > 10 uM Inhibition of reuptake of [3H]-NE (20 nM) by norepinephrine transporter ChEMBL. 11150168
Ki (binding) > 10 uM Inhibition of reuptake of [3H]-5-HT (20 nM) by serotonin transporter ChEMBL. 11150168
Ki (binding) > 10 uM Inhibition of reuptake of [3H]-NE (20 nM) by norepinephrine transporter ChEMBL. 11150168

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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