Detailed information for compound 26995

Basic information

Technical information
  • TDR Targets ID: 26995
  • Name: [(2S,6S)-2,6-di(propan-2-yl)cyclohexyl] N-[2, 6-di(propan-2-yl)phenoxy]sulfonylcarbamate
  • MW: 467.662 | Formula: C25H41NO5S
  • H donors: 1 H acceptors: 3 LogP: 7.9 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NS(=O)(=O)Oc1c(cccc1C(C)C)C(C)C)OC1[C@@H](CCC[C@H]1C(C)C)C(C)C
  • InChi: 1S/C25H41NO5S/c1-15(2)19-11-9-12-20(16(3)4)23(19)30-25(27)26-32(28,29)31-24-21(17(5)6)13-10-14-22(24)18(7)8/h10,13-20,23H,9,11-12H2,1-8H3,(H,26,27)/t19-,20-/m0/s1
  • InChiKey: JSNZZPRQHBHKNX-PMACEKPBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2S,6S)-2,6-diisopropylcyclohexyl] N-(2,6-diisopropylphenoxy)sulfonylcarbamate
  • N-(2,6-diisopropylphenoxy)sulfonylcarbamic acid [(2S,6S)-2,6-diisopropylcyclohexyl] ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Acyl coenzyme A:cholesterol acyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus granulosus sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma mansoni sterol O-acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus multilocularis sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma japonicum ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative Get druggable targets OG5_133487 All targets in OG5_133487
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum diacylglycerol O-acyltransferase 1 Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 547 aa 22.3 %
Neospora caninum sterol O-acyltransferase, putative Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 21.2 %
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 24.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0214 0.0211
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0214 0.0699
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0207 0.1336 1
Echinococcus granulosus enteropeptidase 0.0029 0.0053 0.0049
Echinococcus granulosus lamin 0.0028 0.0044 0.004
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0635 0.3951
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0635 0.4657
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0047 0.0044
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0047 0.0103
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0029 0.0049 0.0162
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Plasmodium vivax aspartyl proteinase, putative 0.0112 0.0653 0.4875
Schistosoma mansoni sterol O-acyltransferase 1 0.0264 0.1746 0.1743
Echinococcus granulosus cathepsin L 0.0025 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.0329
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0214 0.1206
Giardia lamblia G2/mitotic-specific cyclin B 0.0041 0.014 0.0705
Schistosoma mansoni intermediate filament proteins 0.0028 0.0044 0.004
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0463 0.3182 0.3179
Toxoplasma gondii microneme protein MIC4 0.0036 0.0103 0.0333
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0047 0.0044
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.044 0.3015 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0047 0.0044
Echinococcus granulosus tm gpcr rhodopsin 0.0463 0.3182 0.3179
Echinococcus multilocularis calpain A 0.0062 0.0289 0.0286
Trypanosoma brucei protein kinase, putative 0.0052 0.0214 0.1206
Brugia malayi Tachykinin-like peptides receptor 99D 0.0463 0.3182 0.7478
Echinococcus multilocularis serotonin receptor 0.0463 0.3182 0.3179
Echinococcus granulosus voltage dependent calcium channel 0.0541 0.3742 0.374
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0296 0.0292
Echinococcus multilocularis dro:myosuppressin receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Toxoplasma gondii subtilisin SUB12 0.0042 0.0148 0.0538
Brugia malayi Eukaryotic aspartyl protease family protein 0.0027 0.0034 0.0072
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0187 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0047 0.0103
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0103 0.0235
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0124
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0064 0.0305 0.0709
Schistosoma mansoni hypothetical protein 0.0847 0.595 0.5948
Leishmania major hypothetical protein, conserved 0.0022 0.0004 0.0002
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0635 0.2098
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0125 0.0743 0.074
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0463 0.3182 0.7478
Echinococcus granulosus cathepsin b 0.044 0.3015 0.3012
Brugia malayi nuclear receptor NHR-88 0.0028 0.0047 0.0103
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0047 0.0044
Schistosoma mansoni amine GPCR 0.0463 0.3182 0.3179
Brugia malayi G protein-coupled receptor F59B2.13 0.0463 0.3182 0.7478
Plasmodium vivax vivapain-1 0.0025 0.0024 0.0157
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Brugia malayi GnHR receptor homolog 0.0463 0.3182 0.7478
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0463 0.3182 0.3179
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0056 0.0398
Schistosoma mansoni hypothetical protein 0.0029 0.0053 0.0049
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Brugia malayi cathepsin L-like precursor 0.0029 0.0051 0.0111
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0064 0.0305 0.1001
Brugia malayi G protein-coupled receptor 0.0463 0.3182 0.7478
Loa Loa (eye worm) hypothetical protein 0.0321 0.2156 0.5069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Brugia malayi MBOAT family protein 0.0026 0.0028 0.0058
Brugia malayi Serotonin receptor 0.0463 0.3182 0.7478
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0207 0.1336 0.4425
Trypanosoma cruzi cyclin 6, putative 0.0041 0.014 0.0454
Onchocerca volvulus 0.0037 0.0107 0.025
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0024 0.0049
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0171 0.0948
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0066
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Schistosoma mansoni furin-1 (S08 family) 0.0065 0.0308 0.0305
Echinococcus granulosus tachykinin peptides receptor 99D 0.0463 0.3182 0.3179
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0296 0.0695
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Onchocerca volvulus 0.0037 0.0107 0.025
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0047 0.0044
Trichomonas vaginalis cyclin B, putative 0.0041 0.014 0.0748
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0463 0.3182 0.3179
Brugia malayi Dopamine receptor protein 2 0.0463 0.3182 0.7478
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0028 0.0029
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.022 0.1428 0.8163
Brugia malayi Trypsin-like protease protein 5 0.0029 0.0053 0.0116
Plasmodium falciparum plasmepsin IV 0.0112 0.0653 0.4794
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0047 0.0044
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0171 0.1257
Echinococcus granulosus glycoprotein Antigen 5 0.0029 0.0053 0.0049
Brugia malayi hypothetical protein 0.007 0.0346 0.0806
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0044 0.0102
Plasmodium falciparum plasmepsin VII 0.0027 0.0034 0.0073
Loa Loa (eye worm) hypothetical protein 0.0079 0.041 0.0963
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.087 0.0867
Echinococcus granulosus biogenic amine 5HT receptor 0.0463 0.3182 0.3179
Brugia malayi celfurPC protein 0.012 0.0706 0.1652
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0056 0.0245
Echinococcus granulosus Furin 1 0.0035 0.0095 0.0092
Onchocerca volvulus 0.0036 0.0103 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0047 0.0111
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0225
Onchocerca volvulus 0.0035 0.0096 0.0215
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0136 0.082 0.2712
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0028 0.0029
Onchocerca volvulus 0.0036 0.0103 0.0237
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0056 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0187 0.0184
Schistosoma mansoni hypothetical protein 0.0463 0.3182 0.3179
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0028 0.0066
Trichomonas vaginalis cyclins, putative 0.0028 0.0046 0.0139
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0124
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 0.3015 0.3012
Loa Loa (eye worm) hypothetical protein 0.0136 0.0821 0.193
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0037 0.0107 0.0535
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0026 0.0028 0.0186
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0028 0.0066
Trichomonas vaginalis porcupine, putative 0.0026 0.0028 0.0025
Entamoeba histolytica hypothetical protein 0.0074 0.0378 0.27
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0207 0.1336 0.1333
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0047 0.0103
Trypanosoma cruzi GUP1, putative 0.0026 0.0028 0.0082
Echinococcus multilocularis transmembrane protease serine 3 0.0029 0.0053 0.0049
Toxoplasma gondii NAD(+)/NADH kinase domain-containing protein 0.0028 0.0041 0.0058
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0028 0.0041 0.0109
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Onchocerca volvulus 0.0463 0.3182 1
Loa Loa (eye worm) G-protein coupled receptor 0.0463 0.3182 0.748
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Schistosoma mansoni neuropeptide F-like receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis lamin dm0 0.0028 0.0044 0.004
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0047 0.0103
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Loa Loa (eye worm) hypothetical protein 0.0048 0.0187 0.044
Plasmodium falciparum cysteine proteinase falcipain 3 0.0037 0.0107 0.0631
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0062 0.029 0.2149
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0047 0.0044
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0047 0.0044
Toxoplasma gondii transporter, cation channel family protein 0.0099 0.0559 0.237
Loa Loa (eye worm) hypothetical protein 0.0264 0.1746 0.4104
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0056 0.0245
Echinococcus multilocularis glycoprotein Antigen 5 0.0029 0.0053 0.0049
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0541 0.3742 0.374
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0035 0.0095 0.0092
Leishmania major glycerol uptake protein, putative 0.0026 0.0028 0.0142
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.0934 0.2196
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Echinococcus multilocularis fmrfamide receptor 0.0463 0.3182 0.3179
Trypanosoma cruzi poly(p)/ATP NAD kinase, putative 0.0028 0.0041 0.0125
Schistosoma mansoni biogenic amine (5HT) receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis neuropeptides capa receptor 0.0463 0.3182 0.3179
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Toxoplasma gondii kringle domain-containing protein 0.0062 0.029 0.1168
Loa Loa (eye worm) neuropeptide F receptor 0.0463 0.3182 0.748
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0047 0.0044
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0095 0.0458
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0071 0.0357 0.2154
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.4425
Brugia malayi neuropeptide F receptor 0.0463 0.3182 0.7478
Echinococcus granulosus rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Plasmodium falciparum plasmepsin I 0.0112 0.0653 0.4794
Brugia malayi hypothetical protein 0.0123 0.073 0.171
Schistosoma mansoni neuropeptide receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0148 0.0913 0.2146
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0296 0.0292
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0119
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0207 0.1336 0.1333
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0463 0.3182 0.3179
Treponema pallidum hypothetical protein 0.0131 0.0785 0.5786
Echinococcus multilocularis g-protein coupled receptor 0.0463 0.3182 0.3179
Leishmania major hypothetical protein, conserved 0.0062 0.029 0.1641
Onchocerca volvulus 0.0029 0.0053 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0143 0.0873 0.2053
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0187 0.0184
Plasmodium vivax aspartyl protease, putative 0.0027 0.0034 0.0229
Loa Loa (eye worm) hhat protein 0.0026 0.0028 0.0066
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0103 0.0241
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0029 0.0053 0.0049
Loa Loa (eye worm) calpain family protein 1 0.0059 0.0269 0.0633
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0125 0.0743 0.074
Schistosoma mansoni alpha-1 adrenergic receptor 0.0463 0.3182 0.3179
Mycobacterium ulcerans lipase LipD 0.0035 0.0096 0.0337
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0148 0.091 0.0907
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0131 0.0785 0.492
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Brugia malayi aspartic protease BmAsp-1, identical 0.0027 0.0034 0.0072
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0096 0.0225
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0136 0.0821 0.5152
Trypanosoma brucei squalene monooxygenase, putative 0.0264 0.1749 1
Echinococcus granulosus NAD kinase 0.0131 0.0785 0.0782
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.0097
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0047 0.0103
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0047 0.0044
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0141 0.0861 0.0858
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Onchocerca volvulus Cathepsin L homolog 0.0037 0.0107 0.025
Schistosoma mansoni memapsin-2 (A01 family) 0.0027 0.0034 0.0031
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.082 0.5757 0.5756
Schistosoma mansoni hypothetical protein 0.0463 0.3182 0.3179
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0103 0.0241
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0047 0.0044
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0011 0.0007
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0107 0.0104
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0053 0.0049
Onchocerca volvulus 0.0029 0.0053 0.0078
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Brugia malayi 6-phosphofructokinase 0.011 0.0635 0.1486
Toxoplasma gondii PAN domain-containing protein 0.0036 0.0103 0.0333
Echinococcus multilocularis sex peptide receptor 0.0463 0.3182 0.3179
Brugia malayi G-protein coupled receptor 0.0463 0.3182 0.7478
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0214 0.1206
Onchocerca volvulus 0.0463 0.3182 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0493 0.3031
Echinococcus granulosus neuropeptide Y receptor 0.0463 0.3182 0.3179
Echinococcus granulosus single minded 2 0.0036 0.0103 0.01
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0062 0.0289 0.0286
Schistosoma mansoni hypothetical protein 0.0104 0.0591 0.0588
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0072 0.0358 0.4863
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0225
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0207 0.1336 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0047 0.0044
Echinococcus granulosus serotonin receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0463 0.3182 0.3179
Leishmania major glycerol uptake protein, putative 0.0026 0.0028 0.0142
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0207 0.1336 0.7635
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0028 0.0082
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Toxoplasma gondii PAN domain-containing protein 0.0036 0.0103 0.0333
Brugia malayi small heat shock protein 0.0612 0.4254 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0541 0.3742 0.374
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0635 0.4657
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0124
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0241
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0541 0.3742 0.374
Schistosoma mansoni amine GPCR 0.0463 0.3182 0.3179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0056 0.0126
Echinococcus multilocularis musashi 0.0028 0.0044 0.004
Schistosoma mansoni biogenic amine receptor 0.0463 0.3182 0.3179
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0096 0.0092
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0131 0.0785 0.492
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0041 0.014 0.0783
Loa Loa (eye worm) phosphofructokinase 0.011 0.0635 0.1493
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0103 0.0241
Trypanosoma cruzi cyclin, putative 0.0041 0.014 0.0454
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0095 0.0458
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0107 0.0251
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0171 0.0948
Loa Loa (eye worm) hypothetical protein 0.0099 0.0559 0.1314
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0028 0.0142
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0164 0.0161
Brugia malayi Bromodomain containing protein 0.0081 0.0428 0.0999
Echinococcus multilocularis neuropeptides capa receptor 0.0463 0.3182 0.3179
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0095 0.0458
Echinococcus granulosus rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Brugia malayi nuclear hormone receptor 0.0028 0.0047 0.0103
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0028 0.0029
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0036 0.0103 0.0333
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Echinococcus multilocularis voltage dependent calcium channel 0.0541 0.3742 0.374
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0047 0.0044
Brugia malayi neuroendocrine convertase 1 precursor 0.0093 0.0515 0.1204
Mycobacterium ulcerans inorganic polyphosphate/ATP-NAD kinase 0.0131 0.0785 0.5706
Schistosoma mansoni poly(p)/ATP NAD kinase 0.0028 0.0041 0.0038
Echinococcus multilocularis g protein coupled receptor 0.0463 0.3182 0.3179
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0164 0.0161
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0635 0.0632
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0214 0.0699
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0541 0.3742 0.374
Trypanosoma cruzi cyclin, putative 0.0041 0.014 0.0454
Loa Loa (eye worm) hypothetical protein 0.0125 0.0743 0.1747
Loa Loa (eye worm) hypothetical protein 0.0058 0.0262 0.0616
Loa Loa (eye worm) hypothetical protein 0.044 0.3015 0.7087
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0938 0.2199
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0463 0.3182 0.3179
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0171 0.0637
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0071 0.0357 0.0833
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0028 0.0029
Brugia malayi Melatonin receptor type 1A 0.0463 0.3182 0.7478
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0026 0.0028 0.0025
Brugia malayi hypothetical protein 0.0027 0.0034 0.0072
Echinococcus granulosus alpha 1A adrenergic receptor 0.0463 0.3182 0.3179
Brugia malayi Cytochrome P450 family protein 0.0046 0.0172 0.0397
Onchocerca volvulus 0.0029 0.0051 0.0071
Trichomonas vaginalis cyclin B, putative 0.0041 0.014 0.0748
Echinococcus multilocularis NAD kinase 0.0131 0.0785 0.0782
Echinococcus multilocularis neuropeptide receptor A26 0.0939 0.6617 0.6616
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0026 0.0028 0.0066
Echinococcus multilocularis fmrfamide receptor 0.0463 0.3182 0.3179
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0207 0.1336 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0127 0.0785
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0096 0.053
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0208
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0207 0.1336 0.5841
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0296 0.0292
Loa Loa (eye worm) hypothetical protein 0.0037 0.0107 0.0251
Brugia malayi ORL1-like opioid receptor 0.0463 0.3182 0.7478
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0096 0.0218
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.0484 0.048
Brugia malayi Trypsin family protein 0.0029 0.0053 0.0116
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0463 0.3182 0.3179
Echinococcus granulosus cathepsin b 0.044 0.3015 0.3012
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0079 0.041 0.0963
Loa Loa (eye worm) hypothetical protein 0.0029 0.0051 0.0119
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0463 0.3182 0.3179
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0024 0.0021
Echinococcus granulosus g protein coupled receptor 0.0463 0.3182 0.3179
Brugia malayi calpain family protein 1 0.0059 0.0269 0.0626
Echinococcus multilocularis g protein coupled receptor 0.0463 0.3182 0.3179
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0096 0.0337
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0047 0.0044
Giardia lamblia Cathepsin B precursor 0.0148 0.091 0.6691
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Toxoplasma gondii cathepsin B 0.0148 0.091 0.394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0047 0.0111
Echinococcus multilocularis expressed protein 0.0377 0.2565 0.2563
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0064 0.0305 0.1001
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0029 0.0053 0.0116
Echinococcus multilocularis orexin receptor type 2 0.0463 0.3182 0.3179
Echinococcus granulosus Mastin 0.0029 0.0053 0.0049
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0281 0.0278
Mycobacterium leprae Inorganic polyphosphate/ATP-NAD kinase PpnK (Poly(P)/ATP NAD kinase) 0.0103 0.0586 0.9088
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0029 0.0053 0.0049
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Brugia malayi Pepsin A precursor 0.0027 0.0034 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0463 0.3182 0.3179
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0029 0.0049 0.0162
Onchocerca volvulus 0.0036 0.0103 0.0238
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0541 0.3742 0.374
Loa Loa (eye worm) aspartyl protease 6 0.0027 0.0034 0.008
Schistosoma mansoni bromodomain containing protein 0.0069 0.0341 0.0337
Loa Loa (eye worm) hypothetical protein 0.0048 0.0189 0.0444
Brugia malayi Cathepsin L-like precursor 0.0037 0.0107 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0025
Trichomonas vaginalis cyclin B, putative 0.0041 0.014 0.0748
Echinococcus granulosus neuropeptide Y receptor 0.0463 0.3182 0.3179
Brugia malayi MBOAT family protein 0.0026 0.0028 0.0058
Echinococcus granulosus peptide allatostatin:somatostatin 0.0463 0.3182 0.3179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Echinococcus multilocularis neuropeptide Y receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis g protein coupled receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0136 0.0821 0.0818
Brugia malayi Trypsin family protein 0.0029 0.0053 0.0116
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0056 0.0398
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0107 0.0344
Trichomonas vaginalis cyclin A, putative 0.0041 0.014 0.0748
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0187 0.0184
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0207 0.1336 0.1333
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0028 0.0025
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0463 0.3182 0.3179
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0052 0.0049
Schistosoma mansoni microtubule-associated protein tau 0.1408 1 1
Schistosoma mansoni hypothetical protein 0.0463 0.3182 0.3179
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0047 0.0103
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0096 0.0463
Echinococcus multilocularis jun protein 0.0089 0.0484 0.048
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Schistosoma mansoni amine GPCR 0.0784 0.55 0.5499
Echinococcus multilocularis 0.012 0.0706 0.0703
Loa Loa (eye worm) neuropeptide F receptor 0.0463 0.3182 0.748
Echinococcus granulosus g protein coupled receptor 0.0463 0.3182 0.3179
Echinococcus granulosus fmrfamide receptor 0.0463 0.3182 0.3179
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0107 0.0244
Onchocerca volvulus 0.0463 0.3182 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0047 0.0103
Toxoplasma gondii cathepsin CPL 0.0037 0.0107 0.0352
Onchocerca volvulus 0.0029 0.0053 0.0078
Echinococcus multilocularis serotonin receptor 0.0463 0.3182 0.3179
Schistosoma mansoni hypothetical protein 0.0463 0.3182 0.3179
Echinococcus granulosus rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Brugia malayi putative neuropeptide receptor 0.0463 0.3182 0.7478
Schistosoma mansoni biogenic amine receptor 0.0463 0.3182 0.3179
Plasmodium falciparum plasmepsin IX 0.0027 0.0034 0.0073
Brugia malayi AKH receptor 0.0463 0.3182 0.7478
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0047 0.0044
Echinococcus granulosus cathepsin L cysteine proteinase 0.0037 0.0107 0.0104
Mycobacterium ulcerans beta-lactamase 0.0035 0.0096 0.0337
Echinococcus multilocularis neuropeptide receptor 0.0463 0.3182 0.3179
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.8484
Brugia malayi Serotonin receptor 0.0463 0.3182 0.7478
Schistosoma mansoni cathepsin D (A01 family) 0.0331 0.2233 0.223
Brugia malayi hypothetical protein 0.0164 0.1026 0.2406
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0281 0.0278
Onchocerca volvulus 0.0463 0.3182 1
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Onchocerca volvulus 0.0463 0.3182 1
Onchocerca volvulus 0.0029 0.0053 0.0078
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0136 0.0821 0.193
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0241
Loa Loa (eye worm) hypothetical protein 0.0024 0.0016 0.0037
Brugia malayi MAP kinase sur-1 0.0052 0.0214 0.0495
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0053 0.0049
Onchocerca volvulus 0.0463 0.3182 1
Onchocerca volvulus 0.024 0.157 0.489
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0148 0.091 0.5196
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0635 0.0632
Trypanosoma cruzi inorganic polyphosphate/ATP-NAD kinase, putative 0.0028 0.0041 0.0125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0241
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0056 0.0245
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0208
Onchocerca volvulus 0.0029 0.0053 0.0078
Entamoeba histolytica cysteine proteinase, putative 0.0029 0.0051 0.0201
Trichomonas vaginalis cyclins, putative 0.0041 0.014 0.0748
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0171 0.0637
Echinococcus granulosus tissue type plasminogen activator 0.0062 0.029 0.0286
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0208
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0028 0.0025
Echinococcus granulosus hypothetical protein 0.0463 0.3182 0.3179
Onchocerca volvulus 0.0036 0.0103 0.0237
Brugia malayi Trypsin family protein 0.0029 0.0053 0.0116
Trichomonas vaginalis poly(p)/ATP NAD kinase, putative 0.0028 0.0041 0.0109
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0635 0.0632
Onchocerca volvulus 0.007 0.0346 0.1007
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0064 0.0305 0.1001
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0107 0.0631
Schistosoma mansoni hypothetical protein 0.0029 0.0049 0.0046
Echinococcus granulosus cysteine protease 0.0025 0.0024 0.0021
Brugia malayi beta-lactamase 0.0035 0.0096 0.0218
Onchocerca volvulus 0.0125 0.0743 0.2268
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0096 0.0092
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.0917 0.215
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0207 0.1336 0.1333
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0214 0.0503
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Schistosoma mansoni biogenic amine (5HT) receptor 0.0463 0.3182 0.3179
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0635 0.4642
Echinococcus granulosus 7TM GPCR rhodopsin 0.0463 0.3182 0.3179
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0463 0.3182 0.3179
Schistosoma mansoni hypothetical protein 0.0026 0.0028 0.0025
Brugia malayi beta-lactamase family protein 0.0035 0.0096 0.0218
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0241
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.8484
Brugia malayi proprotein convertase 2 0.0093 0.0515 0.1204
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0096 0.0463
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0024 0.012
Mycobacterium tuberculosis Inorganic polyphosphate/ATP-NAD kinase PpnK (poly(P)/ATP NAD kinase) 0.0103 0.0586 0.3586
Echinococcus granulosus g protein coupled receptor 0.0463 0.3182 0.3179
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) cysteine protease 0.0037 0.0107 0.0251
Onchocerca volvulus 0.0028 0.0047 0.0061
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0047 0.0103
Loa Loa (eye worm) TK/ROR protein kinase 0.0062 0.029 0.0681
Onchocerca volvulus 0.0035 0.0096 0.0215
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0112 0.0653 0.1535
Echinococcus multilocularis Mastin 0.0029 0.0053 0.0049
Onchocerca volvulus 0.0463 0.3182 1
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus granulosus furin 0.0148 0.0913 0.091
Brugia malayi Trypsin family protein 0.0125 0.0743 0.1741
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0378 0.0375
Schistosoma mansoni jun-related protein 0.0072 0.0363 0.036
Brugia malayi hypothetical protein 0.0074 0.0378 0.0882
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0047 0.0103
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0463 0.3182 0.748
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Echinococcus granulosus GPCR family 2 0.0048 0.0189 0.0186
Schistosoma mansoni hypothetical protein 0.0048 0.0189 0.0186
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Toxoplasma gondii PAN/Apple domain-containing protein 0.0036 0.0103 0.0333
Toxoplasma gondii hypothetical protein 0.0036 0.0103 0.0333
Loa Loa (eye worm) hypothetical protein 0.0086 0.0466 0.1095
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0207 0.1336 0.4425
Schistosoma mansoni biogenic amine receptor 0.0463 0.3182 0.3179
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Entamoeba histolytica hypothetical protein 0.0074 0.0378 0.27
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0062 0.0289 0.0286
Echinococcus granulosus g-protein coupled receptor 0.0463 0.3182 0.3179
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0037 0.0107 0.0631
Echinococcus granulosus rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0095 0.0458
Toxoplasma gondii aspartyl protease ASP1 0.0112 0.0653 0.2791
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Onchocerca volvulus 0.0036 0.0103 0.0237
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0096 0.0092
Echinococcus granulosus tm gpcr rhodopsin 0.1004 0.7085 0.7084
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0095 0.0458
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0136 0.0821 0.0818
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0047 0.0044
Onchocerca volvulus 0.0036 0.0103 0.0237
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0047 0.0044
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.0004 0.0001
Trypanosoma cruzi cysteine protease, putative 0.0025 0.0024 0.0069
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0028 0.0025
Leishmania major squalene monooxygenase-like protein 0.0264 0.1749 1
Schistosoma mansoni coup transcription factor 0.0028 0.0047 0.0044
Trypanosoma brucei mitotic cyclin 6 0.0041 0.014 0.0783
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0635 0.3951
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0037 0.0107 0.0631
Onchocerca volvulus 0.0036 0.0103 0.0237
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.006 0.0057
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0463 0.3182 0.3179
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0164 0.0161
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0047 0.0044
Echinococcus granulosus dro:myosuppressin receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus multilocularis NAD kinase domain containing protein 1 0.0028 0.0041 0.0038
Brugia malayi bZIP transcription factor family protein 0.0089 0.0484 0.113
Plasmodium falciparum cysteine repeat modular protein 1 0.0062 0.029 0.2024
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Echinococcus granulosus cathepsin l1 0.0029 0.0051 0.0047
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0225
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0207 0.1336 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0056 0.0208
Leishmania major cysteine peptidase A (CPA) 0.0037 0.0107 0.0594
Echinococcus multilocularis neuropeptide receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0281 0.0278
Schistosoma mansoni voltage-gated cation channel 0.0541 0.3742 0.374
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0044 0.0095
Brugia malayi Cyclin, N-terminal domain containing protein 0.0041 0.014 0.0321
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni hypothetical protein 0.0048 0.0189 0.0186
Loa Loa (eye worm) hypothetical protein 0.0053 0.0221 0.052
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0189 0.0444
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0214 0.0699
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.0917 0.0914
Schistosoma mansoni neuropeptide receptor 0.0463 0.3182 0.3179
Onchocerca volvulus 0.0037 0.0107 0.025
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0028 0.0025
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0207 0.1336 1
Echinococcus granulosus jun protein 0.0089 0.0484 0.048
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0112 0.0653 0.065
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0056 0.0216
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0635 0.4657
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.0484 0.048
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0378 0.0375
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0107 0.0344
Plasmodium vivax SET domain protein, putative 0.003 0.006 0.0425
Loa Loa (eye worm) hypothetical protein 0.0238 0.156 0.3667
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0214 0.0211
Schistosoma mansoni hypothetical protein 0.0048 0.0189 0.0186
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0207 0.1336 0.1333
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni neuropeptide receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0029 0.0053 0.0049
Echinococcus multilocularis cyclin B 0.0041 0.014 0.0137
Loa Loa (eye worm) voltage-dependent calcium channel 0.0099 0.0559 0.1314
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0028 0.0025
Brugia malayi neuropeptide F receptor 0.0463 0.3182 0.7478
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.4425
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0214 0.1227
Schistosoma mansoni zinc finger protein 0.0026 0.0028 0.0025
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0541 0.3742 0.8797
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0029 0.0049 0.0162
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Echinococcus multilocularis somatostatin receptor 0.0463 0.3182 0.3179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Echinococcus granulosus orexin receptor type 2 0.0463 0.3182 0.3179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Onchocerca volvulus 0.0062 0.029 0.083
Schistosoma mansoni opsin-like receptor 0.0463 0.3182 0.3179
Brugia malayi Pre-SET motif family protein 0.003 0.006 0.0133
Trichomonas vaginalis set domain proteins, putative 0.024 0.157 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.0094
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0463 0.3182 0.3179
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0072 0.0358 0.1919
Schistosoma mansoni hypothetical protein 0.0847 0.595 0.5948
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0463 0.3182 0.3179
Schistosoma mansoni hypothetical protein 0.0062 0.029 0.0286
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0148 0.0913 0.091
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0096 0.0337
Mycobacterium ulcerans hypothetical protein 0.0035 0.0096 0.0337
Toxoplasma gondii aspartyl protease 0.0027 0.0034 0.0026
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0171 0.0167
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0037 0.0107 0.0251
Brugia malayi jmjC domain containing protein 0.0063 0.0296 0.0688
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0255
Brugia malayi Kringle domain containing protein 0.0062 0.029 0.0674
Brugia malayi Dopamine receptor 0.0463 0.3182 0.7478
Echinococcus granulosus neuropeptide FF receptor 2 0.0463 0.3182 0.3179
Schistosoma mansoni hypothetical protein 0.0072 0.0363 0.036
Onchocerca volvulus 0.0027 0.0034 0.0018
Schistosoma mansoni amine GPCR 0.0463 0.3182 0.3179
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0635 0.362
Onchocerca volvulus 0.0463 0.3182 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0064 0.0305 0.1001
Toxoplasma gondii microneme protein MIC17B 0.0036 0.0103 0.0333
Loa Loa (eye worm) proprotein convertase 2 0.0035 0.0095 0.0223
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0047 0.0044
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Loa Loa (eye worm) hypothetical protein 0.0612 0.4254 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Loa Loa (eye worm) cathepsin B 0.0148 0.091 0.214
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0463 0.3182 0.3179
Entamoeba histolytica inorganic polyphosphate/ATP-NAD kinase, putative 0.0028 0.0041 0.0128
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0028 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0096 0.0463
Schistosoma mansoni neuropeptide F-like receptor 0.0463 0.3182 0.3179
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0136 0.082 0.599
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.011 0.0107
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0047 0.0061
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0635 0.1493
Onchocerca volvulus 0.0035 0.0096 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0103 0.0395
Plasmodium vivax aspartyl protease, putative 0.0027 0.0034 0.0229
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0463 0.3182 0.7478
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis geminin 0.0847 0.595 0.5948
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0136 0.082 0.4679
Brugia malayi hypothetical protein 0.0029 0.0053 0.0116
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.008
Schistosoma mansoni hypothetical protein 0.0062 0.0288 0.0285
Echinococcus multilocularis tissue type plasminogen activator 0.0062 0.029 0.0286
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0112 0.0653 0.1535
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0029 0.0053 0.0049
Plasmodium falciparum plasmepsin VIII, putative 0.0027 0.0034 0.0073
Echinococcus granulosus neuroendocrine convertase 2 0.0093 0.0515 0.0512
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0028 0.0142
Echinococcus granulosus allatostatin A receptor 0.0463 0.3182 0.3179
Leishmania major glycerol uptake protein, putative 0.0026 0.0028 0.0142
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0635 0.3951
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0096 0.0307
Brugia malayi diacylglycerol acyltransferase 0.0026 0.0028 0.0058
Schistosoma mansoni cathepsin F (C01 family) 0.0029 0.0051 0.0047
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0103 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0025
Onchocerca volvulus 0.0463 0.3182 1
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Toxoplasma gondii PAN domain-containing protein 0.0036 0.0103 0.0333
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.011 0.0107
Echinococcus granulosus rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0028 0.0025
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0214 0.0211
Brugia malayi cathepsin B-like cysteine proteinase 0.044 0.3015 0.7085
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0047 0.0044
Echinococcus multilocularis neuroendocrine convertase 2 0.0093 0.0515 0.0512
Brugia malayi Bromodomain containing protein 0.0043 0.0154 0.0355
Trypanosoma cruzi cysteine proteinase, putative 0.0025 0.0024 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0164 0.0161
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0028 0.0025
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0028 0.0025
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0189 0.0186
Onchocerca volvulus 0.0096 0.0533 0.1601
Brugia malayi putative neuropeptide receptor NPR1 0.0463 0.3182 0.7478
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0214 0.0211
Trypanosoma cruzi cruzipain precursor, putative 0.0037 0.0107 0.0344
Brugia malayi larval opioid receptor 0.0463 0.3182 0.7478
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.007 0.0347 0.0344
Onchocerca volvulus 0.0036 0.0103 0.0237
Brugia malayi Cathepsin L-like precursor 0.0029 0.0051 0.0111
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0029 0.0051 0.0157
Loa Loa (eye worm) hypothetical protein 0.007 0.0347 0.0817
Brugia malayi Protein kinase domain containing protein 0.0062 0.029 0.0674
Brugia malayi MBOAT family protein 0.0026 0.0028 0.0058
Schistosoma mansoni adenoreceptor 0.0463 0.3182 0.3179
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.0097
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0047 0.0044
Echinococcus granulosus voltage dependent calcium channel 0.0099 0.0559 0.0556
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0189 0.0186
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0107 0.0631
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Leishmania major ATP-NAD kinase-like protein 0.0028 0.0041 0.0216
Onchocerca volvulus 0.0036 0.0103 0.0237
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0938 0.2206
Plasmodium vivax vivapain-2 0.0037 0.0107 0.0778
Trypanosoma cruzi cysteine peptidase, putative 0.0025 0.0024 0.0069
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0107 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0047 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Schistosoma mansoni growth hormone secretagogue receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0107 0.0104
Echinococcus multilocularis cathepsin L 0.0025 0.0024 0.0021
Brugia malayi jmjC domain containing protein 0.0061 0.0281 0.0654
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0463 0.3182 0.7478
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0047 0.0103
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0027 0.0034 0.0026
Echinococcus multilocularis cathepsin b 0.044 0.3015 0.3012
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0214 0.1279
Echinococcus granulosus neuropeptides capa receptor 0.0463 0.3182 0.3179
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0112 0.0653 0.2791
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0938 0.2199
Schistosoma mansoni neuropeptide receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0368
Brugia malayi PHD-finger family protein 0.0029 0.0054 0.0119
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0011 0.0007
Trichomonas vaginalis cyclin B, putative 0.0041 0.014 0.0748
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0241
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Trypanosoma cruzi squalene monooxygenase, putative 0.0264 0.1749 0.5796
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.009 0.0493 0.049
Onchocerca volvulus 0.0463 0.3182 1
Brugia malayi calpain family protein 1 0.0059 0.0269 0.0626
Trypanosoma cruzi squalene monooxygenase, putative 0.0264 0.1749 0.5796
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0096 0.0463
Echinococcus multilocularis zinc finger protein 0.0024 0.0014 0.0011
Onchocerca volvulus Cathepsin F homolog 0.0037 0.0107 0.025
Leishmania major cyclin 0.0041 0.014 0.0783
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1004 0.7085 0.7084
Trichomonas vaginalis cyclins, putative 0.0041 0.014 0.0748
Brugia malayi hypoxia-induced factor 1 0.0151 0.0934 0.219
Onchocerca volvulus 0.0037 0.0107 0.025
Echinococcus granulosus zinc finger protein 0.0024 0.0014 0.0011
Echinococcus multilocularis cysteine protease 0.0037 0.0107 0.0104
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0207 0.1336 0.7635
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.029 0.0951
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0028 0.0066
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0143 0.0873 0.2053
Echinococcus multilocularis Furin 1 0.0035 0.0095 0.0092
Plasmodium falciparum plasmepsin III 0.0027 0.0034 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Echinococcus granulosus neuropeptide receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0047 0.0111
Toxoplasma gondii aspartyl protease ASP3 0.0027 0.0034 0.0026
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0028 0.0025
Schistosoma mansoni single-minded 0.0049 0.0195 0.0192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0047 0.0111
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0047 0.0044
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0463 0.3182 0.7478
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0047 0.0044
Trypanosoma cruzi GUP1, putative 0.0026 0.0028 0.0082
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0066
Loa Loa (eye worm) calcium channel 0.0541 0.3742 0.8798
Echinococcus multilocularis neuropeptide FF receptor 2 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0164 0.1026 0.2412
Echinococcus granulosus neuropeptides capa receptor 0.0463 0.3182 0.3179
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0635 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.0917 0.0914
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0107 0.0104
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0635 0.3946
Entamoeba histolytica hypothetical protein 0.0074 0.0378 0.27
Plasmodium vivax plasmepsin IV, putative 0.0112 0.0653 0.4875
Giardia lamblia High cysteine membrane protein Group 2 0.0055 0.024 0.1483
Onchocerca volvulus 0.0037 0.0107 0.025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0096 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0047 0.0103
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0028 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.8484
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0047 0.0044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 0.3015 0.3012
Brugia malayi Hhat protein 0.0026 0.0028 0.0058
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Toxoplasma gondii hypothetical protein 0.0079 0.041 0.1704
Trichomonas vaginalis cyclins, putative 0.0041 0.014 0.0748
Onchocerca volvulus 0.0037 0.0107 0.025
Toxoplasma gondii hypothetical protein 0.0036 0.0103 0.0333
Schistosoma mansoni neuropeptide f receptor 76f 0.0463 0.3182 0.3179
Schistosoma mansoni hypothetical protein 0.0029 0.0053 0.0049
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.0157 0.0153
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1463 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0635 0.362
Brugia malayi hypothetical protein 0.0027 0.0034 0.0072
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0028 0.0029
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0463 0.3182 0.748
Brugia malayi Dopamine receptor protein 1 0.0463 0.3182 0.7478
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trichomonas vaginalis esterase, putative 0.0035 0.0096 0.0463
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0207 0.1336 0.7635
Trichomonas vaginalis cyclins, putative 0.0041 0.014 0.0748
Brugia malayi Pre-SET motif family protein 0.021 0.136 0.3193
Schistosoma mansoni myosin xvIII 0.0463 0.3182 0.3179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Echinococcus granulosus cathepsin l cysteine peptidase 0.0037 0.0107 0.0104
Brugia malayi Papain family cysteine protease containing protein 0.0025 0.0024 0.0049
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0095 0.0458
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0107 0.0344
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0062 0.0289 0.0286
Echinococcus granulosus neuropeptide s receptor 0.0939 0.6617 0.6616
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0214 0.0211
Leishmania major glycerol uptake protein, putative 0.0026 0.0028 0.0142
Plasmodium falciparum plasmepsin II 0.0112 0.0653 0.4794
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0541 0.3742 0.374
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0635 0.1493
Onchocerca volvulus 0.0463 0.3182 1
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0127 0.0785
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0463 0.3182 0.7478
Schistosoma mansoni opsin-like receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0025
Plasmodium vivax vivapain-3 0.0025 0.0024 0.0157
Leishmania major hypothetical protein, conserved 0.0026 0.0028 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.006 0.0057
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Loa Loa (eye worm) calpain 0.0022 0.0003 0.0008
Brugia malayi Cathepsin L-like precursor 0.0037 0.0107 0.0244
Brugia malayi MBOAT family protein 0.0026 0.0028 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0047 0.0103
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0112 0.0653 0.065
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0066
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Schistosoma mansoni cathepsin D (A01 family) 0.0331 0.2233 0.223
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0056 0.0126
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0027 0.0034 0.008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Brugia malayi Cathepsin L-like precursor 0.0037 0.0107 0.0244
Schistosoma mansoni lamin 0.0028 0.0044 0.004
Trypanosoma brucei cysteine peptidase C (CPC) 0.0148 0.091 0.5196
Echinococcus granulosus intermediate filament protein 0.0028 0.0044 0.004
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.8484
Giardia lamblia Cathepsin B precursor 0.0148 0.091 0.6691
Echinococcus granulosus lamin dm0 0.0028 0.0044 0.004
Brugia malayi hypothetical protein 0.007 0.0347 0.081
Brugia malayi steroid hormone receptor 0.0028 0.0047 0.0103
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0096 0.0694
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.008
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0056 0.0126
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.0004 0.0002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0463 0.3182 0.3179
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0136 0.0821 0.5152
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0107 0.0104
Onchocerca volvulus 0.003 0.006 0.0101
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0053 0.0049
Echinococcus granulosus 7tm_1 domain containing protein 0.0463 0.3182 0.3179
Loa Loa (eye worm) TYRA-2 protein 0.0463 0.3182 0.748
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0051 0.017
Loa Loa (eye worm) hypothetical protein 0.0041 0.014 0.0329
Brugia malayi Cathepsin L-like precursor 0.0029 0.0051 0.0111
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0208
Echinococcus multilocularis voltage dependent calcium channel 0.0541 0.3742 0.374
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0136 0.082 0.4679
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0111
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.4425
Echinococcus granulosus somatostatin receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) fibroinase 0.0037 0.0107 0.0251
Echinococcus granulosus neuropeptide receptor A26 0.0939 0.6617 0.6616
Entamoeba histolytica cyclin, putative 0.0041 0.014 0.0882
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0172 0.0405
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0207 0.1336 0.7635
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0136 0.082 0.2712
Onchocerca volvulus 0.0036 0.0103 0.0237
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0047 0.0044
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0164 0.0379
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0047 0.0103
Brugia malayi endoprotease bli-4 precursor 0.0148 0.0913 0.214
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0463 0.3182 0.3179
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0463 0.3182 0.3179
Brugia malayi Cathepsin L-like precursor 0.0037 0.0107 0.0244
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0124
Echinococcus granulosus cathepsin L cysteine protease 0.0025 0.0024 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.006 0.0057
Brugia malayi sulfakinin receptor protein 0.0463 0.3182 0.7478
Giardia lamblia Cathepsin B precursor 0.0148 0.091 0.6691
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0635 0.4539
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0136 0.0821 0.193
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0463 0.3182 0.3179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0053 0.0049
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0207 0.1336 1
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0026 0.0028 0.0025
Echinococcus granulosus sterol O acyltransferase 1 0.0264 0.1746 0.1743
Schistosoma mansoni tsg101-related 0.0048 0.0186 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Onchocerca volvulus 0.0037 0.0107 0.025
Loa Loa (eye worm) hypothetical protein 0.0062 0.029 0.0681
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0207 0.1336 0.3135
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0463 0.3182 0.748
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0164 0.0161
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0025 0.0024 0.0021
Loa Loa (eye worm) endoprotease bli-4 0.0148 0.0913 0.2146
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Echinococcus granulosus biogenic amine 5HT receptor 0.0463 0.3182 0.3179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0025 0.0024 0.012
Loa Loa (eye worm) hypothetical protein 0.0046 0.0172 0.0405
Schistosoma mansoni cyclin B 0.0041 0.014 0.0137
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0096 0.0092
Schistosoma mansoni histamine h1 receptor 0.0463 0.3182 0.3179
Toxoplasma gondii PAN domain-containing protein 0.0336 0.2267 1
Echinococcus multilocularis neuropeptide Y receptor 0.0463 0.3182 0.3179
Echinococcus multilocularis neuropeptide s receptor 0.0939 0.6617 0.6616
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0463 0.3182 0.3179
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0103 0.0241
Plasmodium vivax aspartyl proteinase, putative 0.0027 0.0034 0.0229
Onchocerca volvulus 0.0463 0.3182 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0044 0.0102
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0047 0.0061
Brugia malayi PAN domain containing protein 0.0036 0.0103 0.0234
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0214 0.083
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0207 0.1336 1
Trichomonas vaginalis hypothetical protein 0.0029 0.0049 0.0162
Loa Loa (eye worm) hhat protein 0.0026 0.0028 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Echinococcus granulosus cathepsin l1 0.0037 0.0107 0.0104
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0025 0.0024 0.0069
Entamoeba histolytica hypothetical protein 0.0074 0.0378 0.27
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0051 0.017
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0026 0.0028 0.0029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0463 0.3182 0.3179
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0028 0.0025
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0463 0.3182 0.748
Brugia malayi phosphofructokinase 0.011 0.0635 0.1486
Schistosoma mansoni opsin-like receptor 0.0463 0.3182 0.3179
Trypanosoma brucei ATP-NAD kinase-like protein 0.0028 0.0041 0.0216
Onchocerca volvulus 0.0463 0.3182 1
Onchocerca volvulus 0.0037 0.0108 0.0254
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0541 0.3742 0.374
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.044 0.3015 0.3012
Echinococcus granulosus transmembrane protease serine 3 0.0029 0.0053 0.0049
Loa Loa (eye worm) beta-lactamase 0.0035 0.0096 0.0225
Brugia malayi beta-lactamase family protein 0.0035 0.0096 0.0218
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0028 0.0025
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0378 0.0375
Onchocerca volvulus 0.0028 0.0044 0.0049
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0207 0.1336 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0096 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Echinococcus granulosus neuropeptide receptor 0.0463 0.3182 0.3179
Brugia malayi intermediate filament protein 0.0028 0.0044 0.0095
Toxoplasma gondii ABC1 family protein 0.0035 0.0096 0.0302
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0541 0.3742 0.374
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Brugia malayi PAS domain containing protein 0.0049 0.0195 0.0451
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0207 0.1336 0.1333
Onchocerca volvulus NAD kinase 2, mitochondrial homolog 0.0028 0.0041 0.0041
Trichomonas vaginalis hypothetical protein 0.0034 0.0088 0.0414
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0208
Brugia malayi MBOAT family protein 0.0026 0.0028 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0127 0.0606
Schistosoma mansoni hypothetical protein 0.0074 0.0378 0.0375
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0112 0.0653 0.065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Loa Loa (eye worm) melatonin receptor type 1A 0.0463 0.3182 0.748
Schistosoma mansoni tsg101-related 0.0058 0.0263 0.026
Echinococcus multilocularis G protein coupled receptor 139 0.0463 0.3182 0.3179
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0314 0.0311
Echinococcus multilocularis cathepsin b 0.044 0.3015 0.3012
Echinococcus multilocularis microtubule associated protein 2 0.1408 1 1
Echinococcus granulosus NAD kinase domain containing protein 1 0.0028 0.0041 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0189 0.0186
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0064 0.0305 0.1001
Onchocerca volvulus NAD kinase 2, mitochondrial homolog 0.0028 0.0041 0.0041
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0635 0.0632
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0189 0.0186
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Brugia malayi GH09647p 0.0028 0.0041 0.0089
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0047 0.0044
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0047 0.0061
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0148 0.091 0.3011
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0214 0.1227
Onchocerca volvulus 0.0463 0.3182 1
Echinococcus multilocularis allatostatin A receptor 0.0463 0.3182 0.3179
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.0107 0.0594
Leishmania major glycerol uptake protein, putative 0.0026 0.0028 0.0142
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0053 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0037 0.0107 0.0535
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0157 0.0368
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0463 0.3182 0.3179
Onchocerca volvulus 0.0036 0.0103 0.0237
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Loa Loa (eye worm) G-protein coupled receptor 0.0463 0.3182 0.748
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0047 0.0111
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0314 0.0311
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni tsg101-related 0.0058 0.0263 0.026
Brugia malayi ecdysteroid receptor 0.0028 0.0047 0.0103
Echinococcus granulosus sex peptide receptor 0.0463 0.3182 0.3179
Leishmania major hypothetical protein, conserved 0.0035 0.0096 0.053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.009 0.0493 0.3031
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0028 0.0082
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0107 0.0104
Brugia malayi aspartic protease BmAsp-2, identical 0.0027 0.0034 0.0072
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0125 0.0743 0.1747
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Toxoplasma gondii microneme protein MIC17A 0.0036 0.0103 0.0333
Echinococcus multilocularis lamin 0.0028 0.0044 0.004
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0214 0.1206
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0241
Echinococcus multilocularis enteropeptidase 0.0029 0.0053 0.0049
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0463 0.3182 0.3179
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0028 0.0025
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0107 0.0104
Echinococcus granulosus cyclin B 0.0041 0.014 0.0137
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.006 0.0142
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.009 0.0493 0.049
Echinococcus multilocularis rhodopsin orphan GPCR 0.0463 0.3182 0.3179
Echinococcus granulosus expressed protein 0.0377 0.2565 0.2563
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0047 0.0103
Giardia lamblia Inorganic polyphosphate/ATP-NAD kinase, putative 0.0131 0.0785 0.5717
Schistosoma mansoni poly(p)/ATP NAD kinase 0.0028 0.0041 0.0038
Toxoplasma gondii microneme protein, putative 0.0036 0.0103 0.0333
Brugia malayi follicle stimulating hormone receptor 0.0463 0.3182 0.7478
Onchocerca volvulus 0.0463 0.3182 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.8484
Plasmodium falciparum plasmepsin VI 0.0112 0.0653 0.4794
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0053 0.0049
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0207 0.1336 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0214 0.0699
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Trypanosoma cruzi CYC2-like cyclin, putative 0.0041 0.014 0.0454
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0112 0.0653 0.4067
Plasmodium vivax aspartyl protease, putative 0.0027 0.0034 0.0229
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0207 0.1336 0.5841
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0164 0.0161
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.0103 0.0241
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0028 0.0025
Brugia malayi G-protein coupled receptor 0.0463 0.3182 0.7478
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0048 0.0186 0.1232
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0047 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Echinococcus granulosus tm gpcr rhodopsin 0.0463 0.3182 0.3179
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0148 0.091 0.5731
Echinococcus granulosus calpain A 0.0062 0.0289 0.0286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0107 0.0535
Echinococcus multilocularis sodium channel protein 0.0141 0.0861 0.0858
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0214 0.1227
Leishmania major cathepsin L-like protease 0.0037 0.0107 0.0594
Brugia malayi hypothetical protein 0.0463 0.3182 0.7478
Loa Loa (eye worm) hypothetical protein 0.0152 0.0938 0.2206
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0189 0.0437
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.0269 0.0266
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0047 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0164 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0225
Echinococcus granulosus geminin 0.0847 0.595 0.5948
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0053 0.0049
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0463 0.3182 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0463 0.3182 0.748
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0207 0.1336 0.4425
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0541 0.3742 0.374
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0049 0.0162
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.136 0.3198
Loa Loa (eye worm) hypothetical protein 0.0104 0.0591 0.139
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0463 0.3182 0.3179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0107 0.0535
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0028 0.0082
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0207 0.1336 0.7635
Plasmodium vivax unspecified product 0.0025 0.0024 0.0157
Echinococcus multilocularis cysteine protease 0.0037 0.0107 0.0104
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0056 0.0208
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0062 0.0289 0.0286
Toxoplasma gondii PAN domain-containing protein 0.0336 0.2267 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0029 0.0051 0.0111
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0635 0.3951
Plasmodium vivax vivapain-2 0.0037 0.0107 0.0778
Schistosoma mansoni amine GPCR 0.0463 0.3182 0.3179
Onchocerca volvulus Cathepsin L homolog 0.0037 0.0107 0.025
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0207 0.1336 0.1333
Onchocerca volvulus 0.0463 0.3182 1
Echinococcus granulosus tumor susceptibility gene 101 protein 0.007 0.0347 0.0344
Brugia malayi 6-phosphofructokinase 0.011 0.0635 0.1486
Plasmodium falciparum plasmepsin X 0.0027 0.0034 0.0073
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0102
Onchocerca volvulus 0.0036 0.0103 0.0237
Onchocerca volvulus 0.0041 0.014 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0047 0.0103
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0541 0.3742 0.8798
Brugia malayi RE15519p 0.0463 0.3182 0.7478
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0026 0.0028 0.0025
Onchocerca volvulus 0.0027 0.0034 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0214 0.1227
Plasmodium falciparum plasmepsin V 0.0027 0.0034 0.0073
Toxoplasma gondii PAN domain-containing protein 0.0036 0.0103 0.0333
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0207 0.1336 0.1333
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0028 0.0025
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0281 0.0278
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0164 0.0386
Onchocerca volvulus Neuropeptide F receptor homolog 0.0463 0.3182 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0207 0.1336 0.4425
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0189 0.0437
Onchocerca volvulus 0.0463 0.3182 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0269 0.0633
Onchocerca volvulus 0.0028 0.0044 0.0049
Entamoeba histolytica cysteine protease, putative 0.0037 0.0107 0.0631
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0047 0.0111
Entamoeba histolytica hypothetical protein 0.0026 0.0028 0.0029
Brugia malayi Cathepsin L-like precursor 0.0037 0.0107 0.0244
Brugia malayi Cathepsin L-like precursor 0.0037 0.0107 0.0244
Loa Loa (eye worm) ctsf protein 0.0037 0.0107 0.0251
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0047 0.0111
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.022 0.1428 0.4731
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0027 0.0034 0.0031
Trypanosoma cruzi cysteine proteinase, putative 0.0025 0.0024 0.0069
Echinococcus multilocularis GPCR, family 2 0.0048 0.0189 0.0186
Loa Loa (eye worm) hypothetical protein 0.004 0.0129 0.0303
Schistosoma mansoni zinc finger protein 0.0024 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0241
Loa Loa (eye worm) hypothetical protein 0.0463 0.3182 0.748
Echinococcus granulosus G protein coupled receptor 139 0.0463 0.3182 0.3179
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0124
Schistosoma mansoni lamin 0.0028 0.0044 0.004
Brugia malayi Cyclin, N-terminal domain containing protein 0.0041 0.014 0.0321
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0591 0.1384
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0028 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0047 0.0044
Plasmodium vivax plasmepsin V, putative 0.0027 0.0034 0.0229
Loa Loa (eye worm) hypothetical protein 0.0073 0.037 0.087
Echinococcus multilocularis sterol O acyltransferase 1 0.0264 0.1746 0.1743
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0028 0.0066
Loa Loa (eye worm) hypothetical protein 0.0048 0.0187 0.0439
Schistosoma mansoni hypothetical protein 0.0048 0.0189 0.0186
Loa Loa (eye worm) acetyltransferase 0.0149 0.0917 0.2156
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.044 0.3015 0.3012
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0207 0.1336 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0028 0.0025
Schistosoma mansoni poly(p)/ATP NAD kinase 0.0131 0.0785 0.0782
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0195 0.0192
Loa Loa (eye worm) trypsin family protein 0.0029 0.0053 0.0124
Toxoplasma gondii microneme protein MIC17C 0.0036 0.0103 0.0333
Echinococcus multilocularis G-protein coupled receptor, putative 0.0463 0.3182 0.3179

Activities

Activity type Activity value Assay description Source Reference
Delta TC (functional) = -35 % Acute in vivo activity measured by total plasma cholesterol concentration levels (TC) at 30 mg/kg dose ChEMBL. 8632431
IC50 (binding) = 5.7 uM In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver ChEMBL. 8632431
IC50 (binding) = 5.7 uM In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase 1 in microsomes of rat liver ChEMBL. 8632431

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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