Detailed information for compound 315809

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 588.821 | Formula: C26H22ClIN2O4
  • H donors: 2 H acceptors: 4 LogP: 5.75 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)[C@@H](N1[C@@H](c2ccc(cc2)Cl)C(=O)Nc2c(C1=O)cc(I)cc2)c1ccc(cc1)C(C)C
  • InChi: 1S/C26H22ClIN2O4/c1-14(2)15-3-5-17(6-4-15)23(26(33)34)30-22(16-7-9-18(27)10-8-16)24(31)29-21-12-11-19(28)13-20(21)25(30)32/h3-14,22-23H,1-2H3,(H,29,31)(H,33,34)/t22-,23-/m0/s1
  • InChiKey: NECDGFPGXYNUFB-GOTSBHOMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens MDM2 proto-oncogene, E3 ubiquitin protein ligase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.0004 0.0023
Loa Loa (eye worm) hypothetical protein 0.0289 0.052 0.0784
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.021 0.0368 0.095
Loa Loa (eye worm) hypothetical protein 0.1739 0.3324 0.5008
Chlamydia trachomatis succinyl-CoA ligase subunit alpha 0.0057 0.0072 1
Trypanosoma cruzi cysteine peptidase, putative 0.0923 0.1747 0.5084
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Trichomonas vaginalis succinate thiokinase a subunit 0.0057 0.0072 0.0411
Echinococcus multilocularis succinyl coenzyme A ligase (GDP forming) subunit beta 0.0033 0.0025 0.0025
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0013 0.0013
Trichomonas vaginalis importin beta-1, putative 0.0022 0.0004 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Schistosoma mansoni cathepsin s 0.0289 0.052 0.1342
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0031 0.0047
Brugia malayi Cathepsin L-like precursor 0.0634 0.1188 0.179
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.021 0.0368 0.095
Echinococcus granulosus cytochrome P450 2K1 0.0027 0.0013 0.0013
Echinococcus multilocularis importin subunit beta 1 0.0027 0.0014 0.0014
Giardia lamblia Dipeptidyl-peptidase I precursor 0.021 0.0368 0.2796
Brugia malayi follicle stimulating hormone receptor 0.0215 0.0376 0.0567
Leishmania major importin beta-1 subunit, putative 0.0022 0.0004 0.0016
Schistosoma mansoni succinyl-CoA synthetase beta chain 0.0033 0.0025 0.0065
Loa Loa (eye worm) cathepsin B 0.0701 0.1317 0.1984
Leishmania major succinyl-CoA synthetase alpha subunit, putative 0.0057 0.0072 0.0293
Loa Loa (eye worm) carbonic anhydrase 3 0.1287 0.2451 0.3693
Giardia lamblia Cathepsin B precursor 0.021 0.0368 0.2796
Plasmodium falciparum succinyl-CoA synthetase alpha subunit, putative 0.0057 0.0072 0.0411
Leishmania major cysteine peptidase A (CPA) 0.0923 0.1747 0.7127
Brugia malayi Bromodomain containing protein 0.0034 0.0027 0.0041
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0701 0.1317 0.5373
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.021 0.0368 0.2796
Toxoplasma gondii cathepsin CPL 0.0923 0.1747 1
Brugia malayi succinyl-CoA ligase [GDP-forming] alpha-chain, mitochindrial 0.0057 0.0072 0.0108
Schistosoma mansoni Smad4 0.0027 0.0013 0.0034
Onchocerca volvulus 0.0113 0.0181 0.0292
Mycobacterium tuberculosis Probable citrate synthase II CitA 0.0033 0.0025 0.0037
Mycobacterium tuberculosis Probable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha) 0.0057 0.0072 0.0178
Echinococcus multilocularis Smad4 0.0027 0.0013 0.0013
Plasmodium vivax unspecified product 0.021 0.0368 0.2108
Trypanosoma brucei cysteine peptidase C (CPC) 0.0701 0.1317 0.5373
Brugia malayi Inositol-1 0.0034 0.0027 0.0041
Onchocerca volvulus Huntingtin homolog 0.0109 0.0172 0.0278
Mycobacterium ulcerans succinyl-CoA synthetase subunit alpha 0.0057 0.0072 0.0178
Toxoplasma gondii citrate synthase, putative 0.0033 0.0025 0.0144
Brugia malayi Hemopexin family protein 0.2024 0.3876 0.584
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0004
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.021 0.0368 0.2108
Trichomonas vaginalis conserved hypothetical protein 0.021 0.0368 0.2108
Trypanosoma cruzi citrate synthase, putative 0.0033 0.0025 0.0073
Brugia malayi Papain family cysteine protease containing protein 0.021 0.0368 0.0555
Trypanosoma cruzi cysteine peptidase, putative 0.0499 0.0927 0.2698
Brugia malayi PHD-finger family protein 0.0023 0.0006 0.0009
Brugia malayi cathepsin L precursor 0.021 0.0368 0.0555
Entamoeba histolytica cysteine protease, putative 0.021 0.0368 0.2108
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0031 0.0056
Loa Loa (eye worm) CYP4Cod1 0.0058 0.0074 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0634 0.1188 0.68
Schistosoma mansoni carbonic anhydrase-related 0.0605 0.1131 0.2918
Echinococcus granulosus geminin 0.028 0.0503 0.0503
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.021 0.0368 0.2108
Schistosoma mansoni smad 0.0027 0.0013 0.0034
Giardia lamblia Dipeptidyl-peptidase I precursor 0.021 0.0368 0.2796
Echinococcus granulosus dual specificity mitogen activated protein 0.0157 0.0265 0.0265
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1287 0.2451 0.7133
Brugia malayi cathepsin Z-like cysteine proteinase 0.021 0.0368 0.0555
Brugia malayi succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial 0.0033 0.0025 0.0038
Schistosoma mansoni lamin 0.0022 0.0003 0.0008
Giardia lamblia Cysteine protease 0.021 0.0368 0.2796
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0034 0.0027 0.0154
Loa Loa (eye worm) hypothetical protein 0.0289 0.052 0.0784
Brugia malayi Cytochrome P450 family protein 0.0027 0.0013 0.0019
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1796 0.3436 0.8864
Toxoplasma gondii citrate synthase, putative 0.0033 0.0025 0.0144
Mycobacterium tuberculosis Conserved protein 0.0036 0.0031 0.0056
Echinococcus multilocularis citrate synthase 0.0033 0.0025 0.0025
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0032 0.0024 0.0069
Brugia malayi Cytochrome P450 family protein 0.0055 0.0068 0.0103
Echinococcus granulosus cathepsin L cysteine protease 0.0499 0.0927 0.0927
Entamoeba histolytica cysteine proteinase, putative 0.0923 0.1747 1
Echinococcus granulosus citrate synthase 0.0033 0.0025 0.0025
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.021 0.0368 0.2108
Brugia malayi RNA, U transporter 1 0.0077 0.0111 0.0167
Entamoeba histolytica cysteine proteinase 1, putative 0.0499 0.0927 0.5307
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.029 0.0522 0.0787
Plasmodium vivax unspecified product 0.0033 0.0025 0.0144
Loa Loa (eye worm) papain family cysteine protease containing protein 0.021 0.0368 0.0555
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0013 0.0013
Brugia malayi Matrixin family protein 0.1427 0.2722 0.4102
Loa Loa (eye worm) hypothetical protein 0.0075 0.0106 0.016
Echinococcus granulosus lamin 0.0022 0.0003 0.0003
Toxoplasma gondii LsmAD domain-containing protein 0.0047 0.0052 0.0296
Onchocerca volvulus 0.0634 0.1188 0.1948
Schistosoma mansoni succinyl-CoA synthetase beta chain 0.0021 0.0001 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0634 0.1188 0.68
Entamoeba histolytica cysteine proteinase, putative 0.0499 0.0927 0.5307
Mycobacterium leprae PROBABLE CITRATE SYNTHASE I GLTA2 0.0033 0.0025 0.0037
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.021 0.0368 0.2108
Trypanosoma cruzi citrate synthase, putative 0.0033 0.0025 0.0073
Giardia lamblia Cathepsin L precursor 0.021 0.0368 0.2796
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0923 0.1747 1
Loa Loa (eye worm) acetyltransferase 0.0111 0.0176 0.0264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.021 0.0368 0.2108
Echinococcus multilocularis carbonic anhydrase 0.0605 0.1131 0.1131
Trypanosoma cruzi succinyl-CoA ligase [GDP-forming] beta-chain, putative 0.0033 0.0025 0.0074
Onchocerca volvulus 0.0923 0.1747 0.2867
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0499 0.0927 0.2392
Schistosoma mansoni hypothetical protein 0.0024 0.0007 0.0018
Toxoplasma gondii HEAT repeat-containing protein 0.0027 0.0014 0.0079
Onchocerca volvulus Cathepsin L homolog 0.0923 0.1747 0.2867
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0133 0.0201
Plasmodium vivax serine-repeat antigen (SERA) 0.021 0.0368 0.2108
Brugia malayi Bromodomain containing protein 0.0064 0.0086 0.0129
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0032 0.0024 0.0024
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0034 0.0027 0.0154
Plasmodium falciparum serine repeat antigen 3 0.021 0.0368 0.2108
Trypanosoma cruzi succinyl-CoA synthetase alpha subunit, putative 0.0057 0.0072 0.0209
Schistosoma mansoni cathepsin F (C01 family) 0.0634 0.1188 0.3065
Trichomonas vaginalis succinate thiokinase, beta subunit 0.0033 0.0025 0.0145
Echinococcus granulosus cathepsin l1 0.0634 0.1188 0.1188
Echinococcus multilocularis GPCR, family 2 0.0024 0.0007 0.0007
Loa Loa (eye worm) matrix metalloproteinase 0.1427 0.2722 0.4102
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0157 0.0265 0.04
Giardia lamblia Histone acetyltransferase GCN5 0.0029 0.0018 0.0137
Echinococcus multilocularis dual specificity mitogen activated protein 0.0157 0.0265 0.0265
Entamoeba histolytica hypothetical protein 0.021 0.0368 0.2108
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0157 0.0265 0.04
Plasmodium falciparum importin beta, putative 0.0027 0.0014 0.0079
Loa Loa (eye worm) hypothetical protein 0.021 0.0368 0.0555
Loa Loa (eye worm) Smad1 0.0027 0.0013 0.002
Brugia malayi intermediate filament protein 0.0022 0.0003 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0075 0.0106 0.016
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.0018 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Loa Loa (eye worm) intermediate filament protein 0.0022 0.0003 0.0004
Brugia malayi acetyltransferase, GNAT family protein 0.0111 0.0176 0.0264
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0157 0.0265 0.1083
Loa Loa (eye worm) hypothetical protein 0.0038 0.0034 0.0052
Giardia lamblia Cathepsin L precursor 0.021 0.0368 0.2796
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Plasmodium falciparum serine repeat antigen 7 0.021 0.0368 0.2108
Toxoplasma gondii ATP-citrate lyase, putative 0.0292 0.0525 0.3006
Plasmodium falciparum serine repeat antigen 6 0.021 0.0368 0.2108
Loa Loa (eye worm) hypothetical protein 0.0289 0.052 0.0784
Mycobacterium ulcerans succinyl-CoA synthetase subunit beta 0.0033 0.0025 0.0038
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0052 0.0061 0.0061
Plasmodium vivax serine-repeat antigen (SERA), putative 0.021 0.0368 0.2108
Trypanosoma cruzi cysteine peptidase, putative 0.0923 0.1747 0.5084
Brugia malayi MH2 domain containing protein 0.0027 0.0013 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Echinococcus granulosus GPCR family 2 0.0024 0.0007 0.0007
Echinococcus granulosus importin subunit beta 1 0.0027 0.0014 0.0014
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.021 0.0368 0.095
Trypanosoma brucei PAB1-binding protein , putative 0.0047 0.0052 0.0211
Onchocerca volvulus 0.1427 0.2722 0.4471
Trypanosoma cruzi cysteine peptidase, putative 0.0923 0.1747 0.5084
Onchocerca volvulus Cathepsin L homolog 0.0923 0.1747 0.2867
Giardia lamblia Kinase, STE STE20 0.0157 0.0265 0.2015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Onchocerca volvulus Matrilysin homolog 0.1427 0.2722 0.4471
Echinococcus multilocularis succinyl coenzyme A ligase (ADP forming) subunit beta 0.0033 0.0025 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Plasmodium falciparum cysteine proteinase falcipain 3 0.0923 0.1747 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0499 0.0927 0.3782
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0215 0.0376 0.0567
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0133 0.0201
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0074 0.0111
Brugia malayi Papain family cysteine protease containing protein 0.021 0.0368 0.0555
Entamoeba histolytica cysteine proteinase, putative 0.0499 0.0927 0.5307
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0289 0.052 0.0784
Entamoeba histolytica cysteine proteinase, putative 0.0634 0.1188 0.68
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0605 0.1131 0.1704
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0068 0.0103
Trichomonas vaginalis succinate thiokinase a subunit 0.0057 0.0072 0.0411
Trypanosoma cruzi cruzipain precursor, putative 0.0289 0.052 0.1514
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.021 0.0368 0.2108
Leishmania major cytochrome p450-like protein 0.0058 0.0074 0.0301
Trichomonas vaginalis succinate thiokinase, beta subunit 0.0033 0.0025 0.0145
Brugia malayi hypothetical protein 0.0047 0.0052 0.0078
Brugia malayi hypothetical protein 0.0113 0.0181 0.0272
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0031 0.0128
Giardia lamblia Cathepsin L precursor 0.021 0.0368 0.2796
Trypanosoma cruzi succinyl-CoA ligase [GDP-forming] beta-chain, putative 0.0033 0.0025 0.0074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0024 0.0007 0.0011
Entamoeba histolytica cysteine protease, putative 0.021 0.0368 0.2108
Brugia malayi Cathepsin L-like precursor 0.0923 0.1747 0.2632
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0923 0.1747 0.1747
Trypanosoma cruzi PAB1-binding protein , putative 0.0047 0.0052 0.015
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0289 0.052 0.0784
Echinococcus multilocularis 0.0027 0.0013 0.0013
Loa Loa (eye worm) succinate-CoA ligase 0.0033 0.0025 0.0038
Brugia malayi ATP-citrate synthase 0.0292 0.0525 0.0791
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.021 0.0368 0.095
Trypanosoma cruzi cysteine peptidase, putative 0.0289 0.052 0.1514
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0923 0.1747 0.2632
Echinococcus granulosus carbonic anhydrase 0.0605 0.1131 0.1131
Echinococcus multilocularis cathepsin b 0.1796 0.3436 0.3436
Brugia malayi Papain family cysteine protease containing protein 0.021 0.0368 0.0555
Loa Loa (eye worm) hypothetical protein 0.0047 0.0052 0.0078
Plasmodium vivax succinyl-CoA synthetase alpha subunit, putative 0.0057 0.0072 0.0411
Loa Loa (eye worm) hypothetical protein 0.0605 0.1131 0.1704
Onchocerca volvulus 0.0036 0.0031 0.0047
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0034 0.0027 0.0043
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0605 0.1131 0.1704
Plasmodium vivax citrate synthase, mitochondrial precursor, putative 0.0033 0.0025 0.0144
Onchocerca volvulus Huntingtin homolog 0.0109 0.0172 0.0278
Loa Loa (eye worm) hypothetical protein 0.0045 0.0048 0.0072
Brugia malayi MH2 domain containing protein 0.0395 0.0725 0.1092
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0031 0.0047
Plasmodium falciparum ataxin-2 like protein, putative 0.0047 0.0052 0.0296
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0605 0.1131 0.1704
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0605 0.1131 0.1704
Echinococcus granulosus succinyl coenzyme A ligase ADP forming subunit beta 0.0033 0.0025 0.0025
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0013 0.002
Plasmodium vivax serine-repeat antigen (SERA) 0.021 0.0368 0.2108
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1796 0.3436 0.8864
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0031 0.0031
Trypanosoma brucei succinyl-CoA synthetase alpha subunit, putative 0.0057 0.0072 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.021 0.0368 0.2108
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.021 0.0368 0.095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0133 0.0343
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0031 0.0056
Echinococcus granulosus cathepsin L 0.0499 0.0927 0.0927
Echinococcus multilocularis succinyl coenzyme A synthetase alpha subunit 0.0057 0.0072 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Loa Loa (eye worm) hypothetical protein 0.0605 0.1131 0.1704
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0034 0.0027 0.0154
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0013 0.0013
Trichomonas vaginalis STE family protein kinase 0.0157 0.0265 0.1519
Loa Loa (eye worm) latrophilin receptor protein 2 0.0024 0.0007 0.0011
Trichomonas vaginalis STE family protein kinase 0.0157 0.0265 0.1519
Echinococcus granulosus smad 0.0027 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0031 0.0056
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.0409 0.1196
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Schistosoma mansoni hypothetical protein 0.029 0.0522 0.1348
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0047
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Schistosoma mansoni intermediate filament proteins 0.0022 0.0003 0.0008
Schistosoma mansoni cytochrome P450 0.0027 0.0013 0.0033
Schistosoma mansoni hypothetical protein 0.028 0.0503 0.1297
Toxoplasma gondii succinate-Coenzyme A ligase, beta subunit, putative 0.0033 0.0025 0.0145
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1287 0.2451 0.3693
Loa Loa (eye worm) hypothetical protein 0.0634 0.1188 0.179
Trypanosoma cruzi cysteine protease, putative 0.0499 0.0927 0.2698
Plasmodium vivax unspecified product 0.0033 0.0025 0.0144
Echinococcus granulosus cathepsin L cysteine proteinase 0.0923 0.1747 0.1747
Entamoeba histolytica cysteine proteinase, putative 0.0499 0.0927 0.5307
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0157 0.0265 0.1083
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0034 0.0027 0.0004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0034
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0111 0.0176 0.0176
Plasmodium vivax unspecified product 0.0499 0.0927 0.5307
Mycobacterium tuberculosis Probable methylcitrate synthase PrpC 0.0033 0.0025 0.0037
Plasmodium vivax citrate synthase-like protein, putative 0.0033 0.0025 0.0144
Echinococcus multilocularis carbonic anhydrase II 0.1287 0.2451 0.2451
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.021 0.0368 0.2108
Brugia malayi Cathepsin L-like precursor 0.0923 0.1747 0.2632
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0013 0.0013
Schistosoma mansoni inositol monophosphatase 0.0034 0.0027 0.007
Mycobacterium leprae Probable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha) 0.0057 0.0072 0.0178
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0013 0.0037
Giardia lamblia Cysteine protease 0.021 0.0368 0.2796
Entamoeba histolytica cysteine protease, putative 0.021 0.0368 0.2108
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0031 0.018
Plasmodium vivax unspecified product 0.0033 0.0025 0.0144
Mycobacterium tuberculosis Conserved protein 0.0036 0.0031 0.0056
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.021 0.0368 0.2108
Schistosoma mansoni smad1 5 8 and 0.0027 0.0013 0.0034
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0499 0.0927 0.2392
Toxoplasma gondii cathepsin CPC1 0.021 0.0368 0.2108
Leishmania major cytochrome p450-like protein 0.0027 0.0013 0.0052
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.021 0.0368 0.2108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Trypanosoma cruzi cysteine proteinase, putative 0.0499 0.0927 0.2698
Trypanosoma cruzi major cysteine proteinase, putative 0.021 0.0368 0.1072
Giardia lamblia Cathepsin B precursor 0.021 0.0368 0.2796
Echinococcus granulosus carbonic anhydrase II 0.1287 0.2451 0.2451
Brugia malayi Matrixin family protein 0.1427 0.2722 0.4102
Schistosoma mansoni cathepsin S (C01 family) 0.021 0.0368 0.095
Schistosoma mansoni cathepsin F (C01 family) 0.0923 0.1747 0.4507
Giardia lamblia Cysteine protease 0.021 0.0368 0.2796
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0032 0.0024 0.0137
Loa Loa (eye worm) hypothetical protein 0.1427 0.2722 0.4102
Brugia malayi Matrixin family protein 0.3452 0.6637 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0499 0.0927 0.2392
Brugia malayi latrophilin 2 splice variant baaae 0.0051 0.006 0.0091
Trichomonas vaginalis bromodomain-containing protein, putative 0.0034 0.0027 0.0154
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0031 0.018
Plasmodium falciparum ataxin-2 like protein, putative 0.0047 0.0052 0.0296
Plasmodium falciparum citrate synthase-like protein, putative 0.0033 0.0025 0.0144
Brugia malayi Papain family cysteine protease containing protein 0.0923 0.1747 0.2632
Brugia malayi Cytochrome P450 family protein 0.0058 0.0074 0.0111
Loa Loa (eye worm) inositol-1 0.0034 0.0027 0.0041
Loa Loa (eye worm) hypothetical protein 0.0109 0.0172 0.0259
Brugia malayi Probable citrate synthase, mitochondrial precursor, putative 0.0033 0.0025 0.0038
Brugia malayi Cathepsin L-like precursor 0.0923 0.1747 0.2632
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.021 0.0368 0.2108
Echinococcus multilocularis cathepsin L 0.0499 0.0927 0.0927
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.021 0.0368 0.2108
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Echinococcus granulosus intermediate filament protein 0.0022 0.0003 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0047 0.0052 0.015
Echinococcus granulosus survival motor neuron protein 1 0.0178 0.0305 0.0305
Schistosoma mansoni hypothetical protein 0.0051 0.006 0.0155
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.021 0.0368 0.0555
Loa Loa (eye worm) hypothetical protein 0.0109 0.0172 0.0259
Loa Loa (eye worm) hypothetical protein 0.0051 0.006 0.0091
Onchocerca volvulus 0.0057 0.0072 0.0113
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0031 0.0056
Trypanosoma brucei succinyl-CoA ligase [GDP-forming] beta-chain, putative 0.0033 0.0025 0.0103
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0701 0.1317 0.7539
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1796 0.3436 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0075 0.0106 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.021 0.0368 0.2108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0027 0.0111
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0034 0.0027 0.0155
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0499 0.0927 0.2698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0133 0.0133
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.2715 0.5213 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.021 0.0368 0.2108
Brugia malayi Importin beta-1 subunit 0.0027 0.0014 0.0021
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0034 0.0027 0.0155
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.021 0.0368 0.2108
Entamoeba histolytica papain family cysteine protease domain containing protein 0.021 0.0368 0.2108
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0605 0.1131 0.1704
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0022 0.0003 0.0004
Leishmania major hypothetical protein, conserved 0.0032 0.0024 0.0097
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0032 0.0024 0.0069
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0034 0.0027 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0923 0.1747 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0031 0.0047
Entamoeba histolytica papain family cysteine protease domain containing protein 0.021 0.0368 0.2108
Toxoplasma gondii Erv1 / Alr family protein 0.0032 0.0024 0.0137
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0024 0.0007 0.0007
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0027 0.0013 0.0052
Entamoeba histolytica cysteine proteinase, putative 0.0499 0.0927 0.5307
Schistosoma mansoni hypothetical protein 0.0605 0.1131 0.2918
Trypanosoma brucei cytochrome P450, putative 0.0058 0.0074 0.0301
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0031 0.018
Echinococcus multilocularis cysteine protease 0.0923 0.1747 0.1747
Schistosoma mansoni hypothetical protein 0.0024 0.0007 0.0018
Mycobacterium tuberculosis Probable succinyl-CoA synthetase (beta chain) SucC (SCS-beta) 0.0033 0.0025 0.0038
Brugia malayi MH1 domain containing protein 0.0027 0.0013 0.002
Leishmania major cytochrome p450-like protein 0.0027 0.0013 0.0052
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0047
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0634 0.1188 0.3457
Brugia malayi Intermediate filament tail domain containing protein 0.0022 0.0003 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Loa Loa (eye worm) hypothetical protein 0.021 0.0368 0.0555
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Schistosoma mansoni cathepsin F (C01 family) 0.0923 0.1747 0.4507
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0013 0.0037
Loa Loa (eye worm) hypothetical protein 0.0923 0.1747 0.2632
Onchocerca volvulus 0.0923 0.1747 0.2867
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0032 0.0024 0.0069
Echinococcus multilocularis lamin dm0 0.0022 0.0003 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Echinococcus granulosus lamin dm0 0.0022 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0031 0.0091
Giardia lamblia Hypothetical protein 0.021 0.0368 0.2796
Echinococcus multilocularis cathepsin L cysteine protease 0.0923 0.1747 0.1747
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0032 0.0024 0.0137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Echinococcus multilocularis musashi 0.0022 0.0003 0.0003
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.1427 0.2722 0.7023
Brugia malayi hypothetical protein 0.003 0.002 0.003
Plasmodium falciparum serine repeat antigen 9 0.021 0.0368 0.2108
Toxoplasma gondii preprocathepsin c precursor, putative 0.021 0.0368 0.2108
Loa Loa (eye worm) hepatopoietin HPO2 0.0032 0.0024 0.0036
Entamoeba histolytica acetyltransferase, GNAT family 0.0029 0.0018 0.0103
Giardia lamblia Cathepsin B precursor 0.0701 0.1317 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0031 0.0056
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0031 0.0056
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0111 0.0176 0.0453
Schistosoma mansoni smad1 5 8 and 0.0027 0.0013 0.0034
Brugia malayi beta-lactamase family protein 0.0036 0.0031 0.0047
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0031 0.0031
Echinococcus granulosus histone acetyltransferase KAT2B 0.0034 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0024 0.0007 0.0018
Echinococcus granulosus cathepsin b 0.1796 0.3436 0.3436
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0031 0.018
Echinococcus granulosus cysteine protease 0.0499 0.0927 0.0927
Loa Loa (eye worm) hypothetical protein 0.021 0.0368 0.0555
Trypanosoma cruzi cysteine proteinase, putative 0.0499 0.0927 0.2698
Echinococcus granulosus succinyl coenzyme A ligase GDP forming subunit beta 0.0033 0.0025 0.0025
Trypanosoma cruzi importin beta-1 subunit, putative 0.0022 0.0004 0.0011
Giardia lamblia Cathepsin B precursor 0.0701 0.1317 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0133 0.0133
Schistosoma mansoni bromodomain containing protein 0.0055 0.0067 0.0173
Loa Loa (eye worm) cysteine protease 0.0923 0.1747 0.2632
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Brugia malayi cathepsin L-like precursor 0.0634 0.1188 0.179
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.021 0.0368 0.095
Schistosoma mansoni polycystin 1-related 0.0239 0.0423 0.1091
Mycobacterium tuberculosis Probable citrate synthase I GltA2 0.0033 0.0025 0.0037
Loa Loa (eye worm) hypothetical protein 0.1427 0.2722 0.4102
Echinococcus granulosus cathepsin l1 0.0923 0.1747 0.1747
Giardia lamblia Cathepsin L-like protease 0.021 0.0368 0.2796
Plasmodium falciparum histone acetyltransferase GCN5 0.0029 0.0018 0.0103
Schistosoma mansoni lamin 0.0022 0.0003 0.0008
Plasmodium vivax ataxin-2 like protein, putative 0.0047 0.0052 0.0296
Plasmodium falciparum citrate synthase, mitochondrial, putative 0.0033 0.0025 0.0144
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0074 0.0111
Loa Loa (eye worm) cytochrome P450 0.0027 0.0013 0.0019
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0074 0.0215
Loa Loa (eye worm) hypothetical protein 0.1427 0.2722 0.4102
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0021 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0047
Brugia malayi MH2 domain containing protein 0.0027 0.0013 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0923 0.1747 1
Brugia malayi cathepsin L-like cysteine proteinase 0.021 0.0368 0.0555
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.021 0.0368 0.2108
Plasmodium vivax unspecified product 0.0033 0.0025 0.0144
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0074 0.0215
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.0018 0.0018
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.0004 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Leishmania major citrate synthase, putative 0.0033 0.0025 0.0103
Onchocerca volvulus Matrix metalloproteinase homolog 0.3166 0.6085 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0499 0.0927 0.3782
Loa Loa (eye worm) matrixin family protein 0.3166 0.6085 0.9168
Leishmania major succinyl-CoA synthetase alpha subunit, putative 0.0057 0.0072 0.0293
Brugia malayi beta-lactamase 0.0036 0.0031 0.0047
Brugia malayi cathepsin F-like cysteine proteinase 0.021 0.0368 0.0555
Trypanosoma brucei citrate synthase, putative 0.0033 0.0025 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.021 0.0368 0.2108
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0031 0.0056
Loa Loa (eye worm) hypothetical protein 0.0058 0.0074 0.0111
Giardia lamblia Cathepsin L precursor 0.021 0.0368 0.2796
Loa Loa (eye worm) citrate synthase 0.0033 0.0025 0.0038
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.021 0.0368 0.095
Trypanosoma cruzi cruzipain precursor, putative 0.0923 0.1747 0.5084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.021 0.0368 0.2108
Brugia malayi beta-lactamase family protein 0.0036 0.0031 0.0047
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.021 0.0368 0.2108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Schistosoma mansoni succinyl-CoA synthetase-related 0.0057 0.0072 0.0185
Trypanosoma cruzi cysteine peptidase, putative 0.0923 0.1747 0.5084
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0923 0.1747 0.1747
Onchocerca volvulus 0.021 0.0368 0.06
Mycobacterium leprae PROBABLE HYDROLASE 0.1739 0.3324 1
Brugia malayi cytochrome P450 0.0027 0.0013 0.0019
Mycobacterium leprae Probable succinyl-CoA synthase, (beta chain) SucC (SCS-beta) 0.0033 0.0025 0.0038
Plasmodium falciparum carbonic anhydrase 0.0605 0.1131 0.6474
Mycobacterium ulcerans hydrolase 0.1739 0.3324 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0034 0.0027 0.0155
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0024 0.0007 0.0007
Onchocerca volvulus 0.0036 0.0031 0.0047
Loa Loa (eye worm) fibroinase 0.0923 0.1747 0.2632
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0027 0.0013 0.0052
Echinococcus multilocularis cathepsin b 0.1796 0.3436 0.3436
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0031 0.018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.021 0.0368 0.2108
Plasmodium vivax unspecified product 0.0033 0.0025 0.0144
Toxoplasma gondii succinyl-CoA-synthetase alpha SCSA 0.0057 0.0072 0.0411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0499 0.0927 0.5307
Schistosoma mansoni hypothetical protein 0.0027 0.0013 0.0033
Loa Loa (eye worm) hypothetical protein 0.0113 0.0181 0.0272
Leishmania major hypothetical protein, conserved 0.0047 0.0052 0.0211
Leishmania major hypothetical protein, conserved 0.0036 0.0031 0.0128
Schistosoma mansoni hypothetical protein 0.0024 0.0007 0.0018
Brugia malayi Cytochrome P450 family protein 0.0058 0.0074 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0923 0.1747 1
Onchocerca volvulus Matrilysin homolog 0.3166 0.6085 1
Schistosoma mansoni ATP-citrate synthase 0.0247 0.0439 0.1132
Echinococcus multilocularis cathepsin L 0.021 0.0368 0.0368
Schistosoma mansoni hypothetical protein 0.0036 0.0031 0.0081
Loa Loa (eye worm) hypothetical protein 0.0634 0.1188 0.179
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0031 0.018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0031 0.0081
Brugia malayi hypothetical protein 0.0178 0.0305 0.0459
Loa Loa (eye worm) hypothetical protein 0.0605 0.1131 0.1704
Loa Loa (eye worm) hypothetical protein 0.021 0.0368 0.0555
Brugia malayi hypothetical protein 0.0109 0.0172 0.0259
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0021
Trichomonas vaginalis succinate thiokinase a subunit 0.0057 0.0072 0.0411
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0031 0.0056
Brugia malayi Cathepsin L-like precursor 0.0634 0.1188 0.179
Leishmania major citrate synthase, putative 0.0033 0.0025 0.0103
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0701 0.1317 0.3833
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0923 0.1747 0.2632
Onchocerca volvulus Cathepsin F homolog 0.0923 0.1747 0.2867
Plasmodium falciparum serine repeat antigen 8 0.021 0.0368 0.2108
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.021 0.0368 0.2108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Leishmania major carbonic anhydrase-like protein 0.1287 0.2451 1
Schistosoma mansoni smad1 5 8 and 0.0027 0.0013 0.0034
Brugia malayi Cathepsin L-like precursor 0.0923 0.1747 0.2632
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0701 0.1317 0.3398
Schistosoma mansoni carbonic anhydrase-related 0.0605 0.1131 0.2918
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0058 0.0074 0.0184
Entamoeba histolytica cysteine protease, putative 0.0923 0.1747 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0289 0.052 0.0784
Giardia lamblia Hypothetical protein 0.021 0.0368 0.2796
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.021 0.0368 0.2108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Loa Loa (eye worm) hypothetical protein 0.1796 0.3436 0.5177
Toxoplasma gondii cathepsin CPC2 0.021 0.0368 0.2108
Giardia lamblia Cathepsin B precursor 0.021 0.0368 0.2796
Brugia malayi Cathepsin L-like precursor 0.0923 0.1747 0.2632
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.1739 0.3324 0.5008
Plasmodium vivax vivapain-2 0.0923 0.1747 1
Giardia lamblia Cathepsin B precursor 0.021 0.0368 0.2796
Echinococcus granulosus cathepsin l cysteine peptidase 0.0923 0.1747 0.1747
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.021 0.0368 0.2108
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0024 0.0007 0.0007
Onchocerca volvulus 0.0923 0.1747 0.2867
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.003 0.002 0.0022
Entamoeba histolytica hypothetical protein 0.0022 0.0004 0.0023
Entamoeba histolytica cysteine protease, putative 0.021 0.0368 0.2108
Echinococcus granulosus inositol monophosphatase 1 0.0034 0.0027 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Toxoplasma gondii citrate synthase I 0.0033 0.0025 0.0144
Schistosoma mansoni cathepsin B (C01 family) 0.021 0.0368 0.095
Brugia malayi Augmenter of liver regeneration 0.0032 0.0024 0.0036
Echinococcus granulosus carbonic anhydrase 0.0605 0.1131 0.1131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0027 0.0079
Echinococcus multilocularis carbonic anhydrase 0.0605 0.1131 0.1131
Loa Loa (eye worm) hypothetical protein 0.0634 0.1188 0.179
Entamoeba histolytica cysteine protease, putative 0.021 0.0368 0.2108
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0605 0.1131 0.1704
Loa Loa (eye worm) transcription factor SMAD2 0.0395 0.0725 0.1092
Trypanosoma brucei importin beta-1 subunit, putative 0.0027 0.0014 0.0057
Loa Loa (eye worm) MH2 domain-containing protein 0.0395 0.0725 0.1092
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1287 0.2451 0.3693
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Plasmodium falciparum serine repeat antigen 4 0.021 0.0368 0.2108
Toxoplasma gondii cathepsin B 0.0701 0.1317 0.7539
Brugia malayi Cathepsin L-like precursor 0.0923 0.1747 0.2632
Plasmodium vivax unspecified product 0.0289 0.052 0.2978
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0024 0.0007 0.0007
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Brugia malayi Cathepsin L-like cysteine proteinase 0.0634 0.1188 0.179
Echinococcus granulosus snurportin 1 0.029 0.0522 0.0522
Brugia malayi fibroinase precursor 0.021 0.0368 0.0555
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0052 0.0061 0.0061
Onchocerca volvulus 0.0923 0.1747 0.2867
Echinococcus multilocularis carbonic anhydrase 0.0605 0.1131 0.1131
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0031 0.0056
Entamoeba histolytica cysteine proteinase, putative 0.0923 0.1747 1
Mycobacterium ulcerans citrate synthase 2 0.0033 0.0025 0.0037
Brugia malayi Latrophilin receptor protein 2 0.0024 0.0007 0.0011
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1287 0.2451 0.7133
Entamoeba histolytica cysteine protease, putative 0.021 0.0368 0.2108
Loa Loa (eye worm) ATP-citrate synthase 0.0292 0.0525 0.0791
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0036 0.0031 0.0047
Plasmodium falciparum serine repeat antigen 2 0.021 0.0368 0.2108
Schistosoma mansoni carbonic anhydrase-related 0.0605 0.1131 0.2918
Echinococcus multilocularis cathepsin L cysteine protease 0.0923 0.1747 0.1747
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1287 0.2451 0.6323
Loa Loa (eye worm) ctsf protein 0.0923 0.1747 0.2632
Loa Loa (eye worm) hypothetical protein 0.021 0.0368 0.0555
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.021 0.0368 0.095
Loa Loa (eye worm) succinate-CoA ligase 0.0057 0.0072 0.0108
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0013 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Schistosoma mansoni hypothetical protein 0.2024 0.3876 1
Brugia malayi cathepsin B-like cysteine proteinase 0.1796 0.3436 0.5177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Schistosoma mansoni succinyl-CoA synthetase beta chain 0.0033 0.0025 0.0065
Toxoplasma gondii hypothetical protein 0.0605 0.1131 0.6474
Echinococcus multilocularis cysteine protease 0.0923 0.1747 0.1747
Giardia lamblia Dipeptidyl-peptidase I precursor 0.021 0.0368 0.2796
Brugia malayi Cathepsin L-like precursor 0.0289 0.052 0.0784
Plasmodium vivax unspecified product 0.0033 0.0025 0.0144
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0031 0.0056
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.1739 0.3324 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.021 0.0368 0.0555
Giardia lamblia Cathepsin B precursor 0.0701 0.1317 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.021 0.0368 0.2108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0499 0.0927 0.5307
Trypanosoma cruzi major cysteine proteinase, putative 0.021 0.0368 0.1072
Trichomonas vaginalis STE family protein kinase 0.0157 0.0265 0.1519
Plasmodium falciparum succinyl-CoA ligase [ADP-forming] subunit beta, putative 0.0033 0.0025 0.0145
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.519 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0031 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Schistosoma mansoni carbonic anhydrase 0.0605 0.1131 0.2918
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0013 0.002
Echinococcus granulosus histone acetyltransferase KAT2B 0.0106 0.0166 0.0166
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1287 0.2451 0.3693
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.021 0.0368 0.095
Schistosoma mansoni inositol monophosphatase 0.0034 0.0027 0.007
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0032 0.0024 0.0024
Onchocerca volvulus 0.2024 0.3876 0.6368
Brugia malayi Papain family cysteine protease containing protein 0.0499 0.0927 0.1397
Giardia lamblia Cathepsin B precursor 0.021 0.0368 0.2796
Echinococcus multilocularis inositol monophosphatase 1 0.0034 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0021 0.0002 0.0005
Brugia malayi Matrixin family protein 0.1427 0.2722 0.4102
Schistosoma mansoni importin beta-1 0.0027 0.0014 0.0036
Echinococcus multilocularis smad 0.0027 0.0013 0.0013
Echinococcus granulosus cathepsin L 0.021 0.0368 0.0368
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0031 0.0081
Wolbachia endosymbiont of Brugia malayi succinyl-CoA synthetase, alpha subunit 0.0057 0.0072 0.009
Onchocerca volvulus 0.0923 0.1747 0.2867
Brugia malayi Smad1 0.0027 0.0013 0.002
Mycobacterium ulcerans type II citrate synthase 0.0033 0.0025 0.0037
Entamoeba histolytica cysteine proteinase 2 0.0499 0.0927 0.5307
Loa Loa (eye worm) hypothetical protein 0.021 0.0368 0.0555
Echinococcus multilocularis snurportin 1 0.029 0.0522 0.0522
Trichomonas vaginalis esterase, putative 0.0036 0.0031 0.018
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Leishmania major succinyl-CoA ligase [GDP-forming] beta-chain, putative 0.0033 0.0025 0.0103
Schistosoma mansoni protein kinase 0.0157 0.0265 0.0685
Trichomonas vaginalis conserved hypothetical protein 0.021 0.0368 0.2108
Giardia lamblia Cysteine protease 0.021 0.0368 0.2796
Giardia lamblia Cathepsin L precursor 0.021 0.0368 0.2796
Loa Loa (eye worm) hypothetical protein 0.0178 0.0305 0.0459
Echinococcus multilocularis lamin 0.0022 0.0003 0.0003
Schistosoma mansoni cathepsin C 0.021 0.0368 0.095
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0027 0.0013 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.021 0.0368 0.2108
Onchocerca volvulus 0.0036 0.0031 0.0047
Toxoplasma gondii cytochrome p450 superfamily protein 0.0027 0.0013 0.0074
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0034 0.0027 0.0155
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0034 0.0027 0.0154
Schistosoma mansoni survival motor neuron protein 0.0036 0.0031 0.0081
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0027 0.0111
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0031 0.0056
Plasmodium vivax vivapain-3 0.0499 0.0927 0.5307
Mycobacterium tuberculosis Conserved protein 0.0036 0.0031 0.0056
Plasmodium falciparum serine repeat antigen 1 0.021 0.0368 0.2108
Plasmodium vivax vivapain-1 0.0499 0.0927 0.5307
Plasmodium vivax unspecified product 0.0033 0.0025 0.0144
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.021 0.0368 0.2108
Echinococcus multilocularis survival motor neuron protein 1 0.0178 0.0305 0.0305
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.003 0.002 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0157 0.0265 0.0772
Trichomonas vaginalis succinate thiokinase, beta subunit 0.0033 0.0025 0.0145
Plasmodium vivax ATP-specific succinyl-CoA synthetase beta subunit, putative 0.0033 0.0025 0.0145
Onchocerca volvulus 0.0036 0.0031 0.0047
Onchocerca volvulus 0.0923 0.1747 0.2867
Plasmodium vivax vivapain-2 0.0923 0.1747 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Brugia malayi Matrixin family protein 0.1427 0.2722 0.4102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0133 0.0343
Brugia malayi cathepsin Z-like cysteine proteinase 0.021 0.0368 0.0555
Trypanosoma brucei carbonic anhydrase-like protein 0.1287 0.2451 1
Mycobacterium ulcerans citrate synthase 0.0033 0.0025 0.0037
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0047
Mycobacterium leprae Probable lipase LipE 0.0036 0.0031 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0133 0.0343
Brugia malayi MH1 domain containing protein 0.0027 0.0013 0.002
Plasmodium vivax importin-beta 2, putative 0.0027 0.0014 0.0079
Echinococcus granulosus carbonic anhydrase 0.0605 0.1131 0.1131
Loa Loa (eye worm) papain family cysteine protease containing protein 0.021 0.0368 0.0555
Brugia malayi Papain family cysteine protease containing protein 0.0499 0.0927 0.1397
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1796 0.3436 0.8864
Plasmodium falciparum cysteine proteinase falcipain 1 0.0499 0.0927 0.5307
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0133 0.0133
Mycobacterium ulcerans beta-lactamase 0.0036 0.0031 0.0056
Onchocerca volvulus Cathepsin L homolog 0.021 0.0368 0.06
Trypanosoma brucei importin beta-1 subunit, putative 0.0027 0.0014 0.0057
Giardia lamblia Cathepsin L precursor 0.021 0.0368 0.2796
Schistosoma mansoni hypothetical protein 0.028 0.0503 0.1297
Giardia lamblia Cathepsin L-like protease 0.021 0.0368 0.2796
Echinococcus granulosus Smad4 0.0027 0.0013 0.0013
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.1179 0.2242 0.5784
Loa Loa (eye worm) matrixin family protein 0.3452 0.6637 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Toxoplasma gondii Erv1 / Alr family protein 0.0032 0.0024 0.0137
Mycobacterium ulcerans lipase LipD 0.0036 0.0031 0.0056
Brugia malayi Calcitonin receptor-like protein seb-1 0.0075 0.0106 0.016
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0027 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Onchocerca volvulus 0.0923 0.1747 0.2867
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.021 0.0368 0.2108
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.021 0.0368 0.2108
Plasmodium vivax serine-repeat antigen (SERA), putative 0.021 0.0368 0.2108
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0032 0.0024 0.0097
Plasmodium falciparum serine repeat antigen 5 0.021 0.0368 0.2108
Giardia lamblia Encystation-specific protease 0.021 0.0368 0.2796
Toxoplasma gondii ABC1 family protein 0.0036 0.0031 0.018
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Echinococcus granulosus cathepsin b 0.1796 0.3436 0.3436
Echinococcus multilocularis geminin 0.028 0.0503 0.0503
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1287 0.2451 0.6323
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1796 0.3436 0.8864
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0047
Echinococcus granulosus succinyl coenzyme A synthetase alpha subunit 0.0057 0.0072 0.0072
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0021 0.0002 0.0002

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.55 uM Inhibition of p53-binding to HDM2 (human MDM2) by fluorescence polarization peptide displacement assay ChEMBL. 15664854
IC50 (binding) = 1.55 uM Inhibition of p53-binding to HDM2 (human MDM2) by fluorescence polarization peptide displacement assay ChEMBL. 15664854
Kd = 0.083 uM Dissociation constant of the compound was determined; (by measuring difference in protein melting temperature) ChEMBL. 15664854

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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