Detailed information for compound 318339

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 560.768 | Formula: C24H18ClIN2O4
  • H donors: 2 H acceptors: 4 LogP: 4.99 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: Ic1ccc2c(c1)C(=O)N([C@@H](c1ccc(cc1)C)C(=O)O)[C@H](C(=O)N2)c1ccc(cc1)Cl
  • InChi: 1S/C24H18ClIN2O4/c1-13-2-4-15(5-3-13)21(24(31)32)28-20(14-6-8-16(25)9-7-14)22(29)27-19-11-10-17(26)12-18(19)23(28)30/h2-12,20-21H,1H3,(H,27,29)(H,31,32)/t20-,21-/m0/s1
  • InChiKey: RANJWJKEEMFTKN-SFTDATJTSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens MDM2 proto-oncogene, E3 ubiquitin protein ligase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) citrate synthase 0.0033 0.0025 0.0038
Giardia lamblia Cathepsin L precursor 0.021 0.0368 0.2796
Loa Loa (eye worm) hypothetical protein 0.0058 0.0074 0.0111
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0031 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.021 0.0368 0.2108
Brugia malayi cathepsin F-like cysteine proteinase 0.021 0.0368 0.0555
Trypanosoma brucei citrate synthase, putative 0.0033 0.0025 0.0103
Mycobacterium ulcerans hydrolase 0.1739 0.3324 1
Plasmodium falciparum carbonic anhydrase 0.0605 0.1131 0.6474
Mycobacterium leprae Probable succinyl-CoA synthase, (beta chain) SucC (SCS-beta) 0.0033 0.0025 0.0038
Brugia malayi cytochrome P450 0.0027 0.0013 0.0019
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0923 0.1747 0.1747
Mycobacterium leprae PROBABLE HYDROLASE 0.1739 0.3324 1
Onchocerca volvulus 0.021 0.0368 0.06
Trypanosoma cruzi cysteine peptidase, putative 0.0923 0.1747 0.5084
Schistosoma mansoni succinyl-CoA synthetase-related 0.0057 0.0072 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.021 0.0368 0.2108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.021 0.0368 0.2108
Trypanosoma cruzi cruzipain precursor, putative 0.0923 0.1747 0.5084
Brugia malayi beta-lactamase family protein 0.0036 0.0031 0.0047
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.021 0.0368 0.095
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.003 0.0018 0.0018
Plasmodium vivax unspecified product 0.0033 0.0025 0.0144
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0074 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.021 0.0368 0.2108
Brugia malayi cathepsin L-like cysteine proteinase 0.021 0.0368 0.0555
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0923 0.1747 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0133 0.0133
Brugia malayi MH2 domain containing protein 0.0027 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0047
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0021 0.0002 0.0002
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0074 0.0215
Loa Loa (eye worm) hypothetical protein 0.1427 0.2722 0.4102
Loa Loa (eye worm) cytochrome P450 0.0027 0.0013 0.0019
Brugia malayi beta-lactamase 0.0036 0.0031 0.0047
Leishmania major succinyl-CoA synthetase alpha subunit, putative 0.0057 0.0072 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0499 0.0927 0.3782
Loa Loa (eye worm) matrixin family protein 0.3166 0.6085 0.9168
Onchocerca volvulus Matrix metalloproteinase homolog 0.3166 0.6085 1
Leishmania major citrate synthase, putative 0.0033 0.0025 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.0004 0.0023
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.021 0.0368 0.095
Brugia malayi cathepsin L-like precursor 0.0634 0.1188 0.179
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Loa Loa (eye worm) cysteine protease 0.0923 0.1747 0.2632
Schistosoma mansoni bromodomain containing protein 0.0055 0.0067 0.0173
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0133 0.0133
Echinococcus granulosus succinyl coenzyme A ligase GDP forming subunit beta 0.0033 0.0025 0.0025
Trypanosoma cruzi cysteine proteinase, putative 0.0499 0.0927 0.2698
Trypanosoma cruzi importin beta-1 subunit, putative 0.0022 0.0004 0.0011
Giardia lamblia Cathepsin B precursor 0.0701 0.1317 1
Loa Loa (eye worm) hypothetical protein 0.021 0.0368 0.0555
Echinococcus granulosus cysteine protease 0.0499 0.0927 0.0927
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0031 0.018
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0074 0.0111
Plasmodium falciparum citrate synthase, mitochondrial, putative 0.0033 0.0025 0.0144
Plasmodium vivax ataxin-2 like protein, putative 0.0047 0.0052 0.0296
Schistosoma mansoni lamin 0.0022 0.0003 0.0008
Plasmodium falciparum histone acetyltransferase GCN5 0.0029 0.0018 0.0103
Giardia lamblia Cathepsin L-like protease 0.021 0.0368 0.2796
Echinococcus granulosus cathepsin l1 0.0923 0.1747 0.1747
Mycobacterium tuberculosis Probable citrate synthase I GltA2 0.0033 0.0025 0.0037
Loa Loa (eye worm) hypothetical protein 0.1427 0.2722 0.4102
Schistosoma mansoni polycystin 1-related 0.0239 0.0423 0.1091
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0111 0.0176 0.0453
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0031 0.0056
Mycobacterium ulcerans hypothetical protein 0.0036 0.0031 0.0056
Loa Loa (eye worm) hepatopoietin HPO2 0.0032 0.0024 0.0036
Entamoeba histolytica acetyltransferase, GNAT family 0.0029 0.0018 0.0103
Giardia lamblia Cathepsin B precursor 0.0701 0.1317 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.021 0.0368 0.2108
Plasmodium falciparum serine repeat antigen 9 0.021 0.0368 0.2108
Brugia malayi hypothetical protein 0.003 0.002 0.003
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.1427 0.2722 0.7023
Echinococcus multilocularis musashi 0.0022 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Echinococcus granulosus cathepsin b 0.1796 0.3436 0.3436
Schistosoma mansoni hypothetical protein 0.0024 0.0007 0.0018
Echinococcus granulosus histone acetyltransferase KAT2B 0.0034 0.0027 0.0027
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0031 0.0031
Brugia malayi beta-lactamase family protein 0.0036 0.0031 0.0047
Schistosoma mansoni smad1 5 8 and 0.0027 0.0013 0.0034
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0003
Echinococcus granulosus carbonic anhydrase 0.0605 0.1131 0.1131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Brugia malayi Augmenter of liver regeneration 0.0032 0.0024 0.0036
Schistosoma mansoni cathepsin B (C01 family) 0.021 0.0368 0.095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Toxoplasma gondii citrate synthase I 0.0033 0.0025 0.0144
Echinococcus granulosus inositol monophosphatase 1 0.0034 0.0027 0.0027
Entamoeba histolytica cysteine protease, putative 0.021 0.0368 0.2108
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.003 0.002 0.0022
Entamoeba histolytica hypothetical protein 0.0022 0.0004 0.0023
Onchocerca volvulus 0.0923 0.1747 0.2867
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0024 0.0007 0.0007
Echinococcus granulosus cathepsin l cysteine peptidase 0.0923 0.1747 0.1747
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.021 0.0368 0.2108
Trypanosoma brucei importin beta-1 subunit, putative 0.0027 0.0014 0.0057
Loa Loa (eye worm) MH2 domain-containing protein 0.0395 0.0725 0.1092
Loa Loa (eye worm) transcription factor SMAD2 0.0395 0.0725 0.1092
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0605 0.1131 0.1704
Entamoeba histolytica cysteine protease, putative 0.021 0.0368 0.2108
Loa Loa (eye worm) hypothetical protein 0.0634 0.1188 0.179
Echinococcus multilocularis carbonic anhydrase 0.0605 0.1131 0.1131
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0027 0.0079
Giardia lamblia Hypothetical protein 0.021 0.0368 0.2796
Brugia malayi cathepsin F-like cysteine proteinase 0.0289 0.052 0.0784
Entamoeba histolytica cysteine protease, putative 0.0923 0.1747 1
Schistosoma mansoni carbonic anhydrase-related 0.0605 0.1131 0.2918
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0058 0.0074 0.0184
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0701 0.1317 0.3398
Brugia malayi Cathepsin L-like precursor 0.0923 0.1747 0.2632
Schistosoma mansoni smad1 5 8 and 0.0027 0.0013 0.0034
Leishmania major carbonic anhydrase-like protein 0.1287 0.2451 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.021 0.0368 0.2108
Plasmodium falciparum serine repeat antigen 8 0.021 0.0368 0.2108
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Onchocerca volvulus Cathepsin F homolog 0.0923 0.1747 0.2867
Giardia lamblia Cathepsin B precursor 0.021 0.0368 0.2796
Plasmodium vivax vivapain-2 0.0923 0.1747 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.1739 0.3324 0.5008
Brugia malayi Cathepsin L-like precursor 0.0923 0.1747 0.2632
Giardia lamblia Cathepsin B precursor 0.021 0.0368 0.2796
Loa Loa (eye worm) hypothetical protein 0.1796 0.3436 0.5177
Toxoplasma gondii cathepsin CPC2 0.021 0.0368 0.2108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.021 0.0368 0.2108
Loa Loa (eye worm) hypothetical protein 0.0027 0.0014 0.0021
Brugia malayi hypothetical protein 0.0109 0.0172 0.0259
Loa Loa (eye worm) hypothetical protein 0.021 0.0368 0.0555
Loa Loa (eye worm) hypothetical protein 0.0605 0.1131 0.1704
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0031 0.0081
Brugia malayi hypothetical protein 0.0178 0.0305 0.0459
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0031 0.018
Loa Loa (eye worm) hypothetical protein 0.0634 0.1188 0.179
Schistosoma mansoni hypothetical protein 0.0036 0.0031 0.0081
Echinococcus multilocularis cathepsin L 0.021 0.0368 0.0368
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0923 0.1747 0.2632
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0701 0.1317 0.3833
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Leishmania major citrate synthase, putative 0.0033 0.0025 0.0103
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0031 0.0056
Brugia malayi Cathepsin L-like precursor 0.0634 0.1188 0.179
Trichomonas vaginalis succinate thiokinase a subunit 0.0057 0.0072 0.0411
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0031 0.018
Echinococcus multilocularis cathepsin b 0.1796 0.3436 0.3436
Loa Loa (eye worm) fibroinase 0.0923 0.1747 0.2632
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0027 0.0013 0.0052
Onchocerca volvulus 0.0036 0.0031 0.0047
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0024 0.0007 0.0007
Trichomonas vaginalis inositol monophosphatase, putative 0.0034 0.0027 0.0155
Schistosoma mansoni ATP-citrate synthase 0.0247 0.0439 0.1132
Onchocerca volvulus Matrilysin homolog 0.3166 0.6085 1
Brugia malayi Cytochrome P450 family protein 0.0058 0.0074 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0923 0.1747 1
Schistosoma mansoni hypothetical protein 0.0024 0.0007 0.0018
Leishmania major hypothetical protein, conserved 0.0036 0.0031 0.0128
Leishmania major hypothetical protein, conserved 0.0047 0.0052 0.0211
Loa Loa (eye worm) hypothetical protein 0.0113 0.0181 0.0272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0499 0.0927 0.5307
Schistosoma mansoni hypothetical protein 0.0027 0.0013 0.0033
Toxoplasma gondii succinyl-CoA-synthetase alpha SCSA 0.0057 0.0072 0.0411
Plasmodium vivax unspecified product 0.0033 0.0025 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.021 0.0368 0.2108
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0031 0.0081
Echinococcus granulosus cathepsin L 0.021 0.0368 0.0368
Brugia malayi Matrixin family protein 0.1427 0.2722 0.4102
Echinococcus multilocularis smad 0.0027 0.0013 0.0013
Schistosoma mansoni importin beta-1 0.0027 0.0014 0.0036
Schistosoma mansoni hypothetical protein 0.0021 0.0002 0.0005
Echinococcus multilocularis inositol monophosphatase 1 0.0034 0.0027 0.0027
Giardia lamblia Cathepsin B precursor 0.021 0.0368 0.2796
Brugia malayi Papain family cysteine protease containing protein 0.0499 0.0927 0.1397
Onchocerca volvulus 0.2024 0.3876 0.6368
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Trichomonas vaginalis esterase, putative 0.0036 0.0031 0.018
Echinococcus multilocularis snurportin 1 0.029 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.021 0.0368 0.0555
Entamoeba histolytica cysteine proteinase 2 0.0499 0.0927 0.5307
Mycobacterium ulcerans type II citrate synthase 0.0033 0.0025 0.0037
Onchocerca volvulus 0.0923 0.1747 0.2867
Brugia malayi Smad1 0.0027 0.0013 0.002
Wolbachia endosymbiont of Brugia malayi succinyl-CoA synthetase, alpha subunit 0.0057 0.0072 0.009
Trypanosoma cruzi major cysteine proteinase, putative 0.021 0.0368 0.1072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0499 0.0927 0.5307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.021 0.0368 0.2108
Giardia lamblia Cathepsin B precursor 0.0701 0.1317 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.021 0.0368 0.0555
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.1739 0.3324 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0031 0.0056
Plasmodium vivax unspecified product 0.0033 0.0025 0.0144
Brugia malayi Cathepsin L-like precursor 0.0289 0.052 0.0784
Echinococcus multilocularis cysteine protease 0.0923 0.1747 0.1747
Giardia lamblia Dipeptidyl-peptidase I precursor 0.021 0.0368 0.2796
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0032 0.0024 0.0024
Schistosoma mansoni inositol monophosphatase 0.0034 0.0027 0.007
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.021 0.0368 0.095
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1287 0.2451 0.3693
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0013 0.002
Echinococcus granulosus histone acetyltransferase KAT2B 0.0106 0.0166 0.0166
Schistosoma mansoni carbonic anhydrase 0.0605 0.1131 0.2918
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0031 0.0091
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.519 1 1
Plasmodium falciparum succinyl-CoA ligase [ADP-forming] subunit beta, putative 0.0033 0.0025 0.0145
Trichomonas vaginalis STE family protein kinase 0.0157 0.0265 0.1519
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.021 0.0368 0.095
Loa Loa (eye worm) hypothetical protein 0.021 0.0368 0.0555
Loa Loa (eye worm) ctsf protein 0.0923 0.1747 0.2632
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1287 0.2451 0.6323
Echinococcus multilocularis cathepsin L cysteine protease 0.0923 0.1747 0.1747
Plasmodium falciparum serine repeat antigen 2 0.021 0.0368 0.2108
Schistosoma mansoni carbonic anhydrase-related 0.0605 0.1131 0.2918
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0036 0.0031 0.0047
Entamoeba histolytica cysteine protease, putative 0.021 0.0368 0.2108
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1287 0.2451 0.7133
Loa Loa (eye worm) ATP-citrate synthase 0.0292 0.0525 0.0791
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Brugia malayi Latrophilin receptor protein 2 0.0024 0.0007 0.0011
Mycobacterium ulcerans citrate synthase 2 0.0033 0.0025 0.0037
Entamoeba histolytica cysteine proteinase, putative 0.0923 0.1747 1
Toxoplasma gondii hypothetical protein 0.0605 0.1131 0.6474
Schistosoma mansoni succinyl-CoA synthetase beta chain 0.0033 0.0025 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Brugia malayi cathepsin B-like cysteine proteinase 0.1796 0.3436 0.5177
Schistosoma mansoni hypothetical protein 0.2024 0.3876 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0013 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Loa Loa (eye worm) succinate-CoA ligase 0.0057 0.0072 0.0108
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0024 0.0007 0.0007
Plasmodium vivax unspecified product 0.0289 0.052 0.2978
Brugia malayi Cathepsin L-like precursor 0.0923 0.1747 0.2632
Toxoplasma gondii cathepsin B 0.0701 0.1317 0.7539
Plasmodium falciparum serine repeat antigen 4 0.021 0.0368 0.2108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1287 0.2451 0.3693
Echinococcus multilocularis carbonic anhydrase 0.0605 0.1131 0.1131
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0031 0.0056
Onchocerca volvulus 0.0923 0.1747 0.2867
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0052 0.0061 0.0061
Brugia malayi fibroinase precursor 0.021 0.0368 0.0555
Echinococcus granulosus snurportin 1 0.029 0.0522 0.0522
Brugia malayi Cathepsin L-like cysteine proteinase 0.0634 0.1188 0.179
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0032 0.0024 0.0097
Plasmodium falciparum serine repeat antigen 5 0.021 0.0368 0.2108
Plasmodium vivax serine-repeat antigen (SERA), putative 0.021 0.0368 0.2108
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.021 0.0368 0.2108
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.021 0.0368 0.2108
Onchocerca volvulus 0.0923 0.1747 0.2867
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0027 0.0079
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0021 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0047
Echinococcus granulosus succinyl coenzyme A synthetase alpha subunit 0.0057 0.0072 0.0072
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1796 0.3436 0.8864
Echinococcus multilocularis geminin 0.028 0.0503 0.0503
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1287 0.2451 0.6323
Echinococcus granulosus cathepsin b 0.1796 0.3436 0.3436
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Toxoplasma gondii ABC1 family protein 0.0036 0.0031 0.018
Giardia lamblia Encystation-specific protease 0.021 0.0368 0.2796
Trypanosoma brucei importin beta-1 subunit, putative 0.0027 0.0014 0.0057
Onchocerca volvulus Cathepsin L homolog 0.021 0.0368 0.06
Mycobacterium ulcerans beta-lactamase 0.0036 0.0031 0.0056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0133 0.0133
Plasmodium falciparum cysteine proteinase falcipain 1 0.0499 0.0927 0.5307
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1796 0.3436 0.8864
Loa Loa (eye worm) papain family cysteine protease containing protein 0.021 0.0368 0.0555
Brugia malayi Papain family cysteine protease containing protein 0.0499 0.0927 0.1397
Echinococcus granulosus carbonic anhydrase 0.0605 0.1131 0.1131
Plasmodium vivax importin-beta 2, putative 0.0027 0.0014 0.0079
Brugia malayi MH1 domain containing protein 0.0027 0.0013 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0133 0.0343
Mycobacterium ulcerans lipase LipD 0.0036 0.0031 0.0056
Brugia malayi Calcitonin receptor-like protein seb-1 0.0075 0.0106 0.016
Toxoplasma gondii Erv1 / Alr family protein 0.0032 0.0024 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Loa Loa (eye worm) matrixin family protein 0.3452 0.6637 1
Echinococcus granulosus Smad4 0.0027 0.0013 0.0013
Giardia lamblia Cathepsin L-like protease 0.021 0.0368 0.2796
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.1179 0.2242 0.5784
Schistosoma mansoni hypothetical protein 0.028 0.0503 0.1297
Giardia lamblia Cathepsin L precursor 0.021 0.0368 0.2796
Onchocerca volvulus 0.0036 0.0031 0.0047
Plasmodium vivax ATP-specific succinyl-CoA synthetase beta subunit, putative 0.0033 0.0025 0.0145
Trichomonas vaginalis succinate thiokinase, beta subunit 0.0033 0.0025 0.0145
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0157 0.0265 0.0772
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.003 0.002 0.0022
Echinococcus multilocularis survival motor neuron protein 1 0.0178 0.0305 0.0305
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.021 0.0368 0.2108
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0011
Mycobacterium leprae Probable lipase LipE 0.0036 0.0031 0.0056
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0047
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0034
Mycobacterium ulcerans citrate synthase 0.0033 0.0025 0.0037
Trypanosoma brucei carbonic anhydrase-like protein 0.1287 0.2451 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.021 0.0368 0.0555
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0133 0.0343
Brugia malayi Matrixin family protein 0.1427 0.2722 0.4102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Plasmodium vivax vivapain-2 0.0923 0.1747 1
Onchocerca volvulus 0.0923 0.1747 0.2867
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.021 0.0368 0.2108
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0027 0.0013 0.0037
Schistosoma mansoni cathepsin C 0.021 0.0368 0.095
Echinococcus multilocularis lamin 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0178 0.0305 0.0459
Giardia lamblia Cysteine protease 0.021 0.0368 0.2796
Giardia lamblia Cathepsin L precursor 0.021 0.0368 0.2796
Trichomonas vaginalis conserved hypothetical protein 0.021 0.0368 0.2108
Schistosoma mansoni protein kinase 0.0157 0.0265 0.0685
Leishmania major succinyl-CoA ligase [GDP-forming] beta-chain, putative 0.0033 0.0025 0.0103
Plasmodium vivax unspecified product 0.0033 0.0025 0.0144
Plasmodium vivax vivapain-1 0.0499 0.0927 0.5307
Plasmodium falciparum serine repeat antigen 1 0.021 0.0368 0.2108
Mycobacterium tuberculosis Conserved protein 0.0036 0.0031 0.0056
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0031 0.0056
Plasmodium vivax vivapain-3 0.0499 0.0927 0.5307
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0027 0.0111
Schistosoma mansoni survival motor neuron protein 0.0036 0.0031 0.0081
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0034 0.0027 0.0154
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0034 0.0027 0.0155
Toxoplasma gondii cytochrome p450 superfamily protein 0.0027 0.0013 0.0074
Onchocerca volvulus 0.0036 0.0031 0.0047
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0034 0.0027 0.0154
Giardia lamblia Cysteine protease 0.021 0.0368 0.2796
Schistosoma mansoni lamin 0.0022 0.0003 0.0008
Brugia malayi succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial 0.0033 0.0025 0.0038
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1287 0.2451 0.7133
Brugia malayi cathepsin Z-like cysteine proteinase 0.021 0.0368 0.0555
Giardia lamblia Dipeptidyl-peptidase I precursor 0.021 0.0368 0.2796
Echinococcus granulosus dual specificity mitogen activated protein 0.0157 0.0265 0.0265
Schistosoma mansoni smad 0.0027 0.0013 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.021 0.0368 0.2108
Echinococcus granulosus geminin 0.028 0.0503 0.0503
Schistosoma mansoni carbonic anhydrase-related 0.0605 0.1131 0.2918
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0634 0.1188 0.68
Echinococcus granulosus citrate synthase 0.0033 0.0025 0.0025
Entamoeba histolytica cysteine proteinase, putative 0.0923 0.1747 1
Echinococcus granulosus cathepsin L cysteine protease 0.0499 0.0927 0.0927
Brugia malayi Cytochrome P450 family protein 0.0055 0.0068 0.0103
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0032 0.0024 0.0069
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Echinococcus multilocularis citrate synthase 0.0033 0.0025 0.0025
Mycobacterium tuberculosis Conserved protein 0.0036 0.0031 0.0056
Toxoplasma gondii citrate synthase, putative 0.0033 0.0025 0.0144
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1796 0.3436 0.8864
Brugia malayi Cytochrome P450 family protein 0.0027 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0289 0.052 0.0784
Plasmodium vivax unspecified product 0.021 0.0368 0.2108
Echinococcus multilocularis Smad4 0.0027 0.0013 0.0013
Trypanosoma brucei cysteine peptidase C (CPC) 0.0701 0.1317 0.5373
Mycobacterium tuberculosis Probable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha) 0.0057 0.0072 0.0178
Mycobacterium tuberculosis Probable citrate synthase II CitA 0.0033 0.0025 0.0037
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0031 0.0056
Loa Loa (eye worm) CYP4Cod1 0.0058 0.0074 0.0111
Brugia malayi Papain family cysteine protease containing protein 0.021 0.0368 0.0555
Trypanosoma cruzi cysteine peptidase, putative 0.0499 0.0927 0.2698
Entamoeba histolytica cysteine protease, putative 0.021 0.0368 0.2108
Brugia malayi PHD-finger family protein 0.0023 0.0006 0.0009
Brugia malayi cathepsin L precursor 0.021 0.0368 0.0555
Trypanosoma cruzi citrate synthase, putative 0.0033 0.0025 0.0073
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.021 0.0368 0.2108
Trichomonas vaginalis conserved hypothetical protein 0.021 0.0368 0.2108
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Toxoplasma gondii citrate synthase, putative 0.0033 0.0025 0.0144
Loa Loa (eye worm) hypothetical protein 0.0022 0.0003 0.0004
Brugia malayi Hemopexin family protein 0.2024 0.3876 0.584
Mycobacterium ulcerans succinyl-CoA synthetase subunit alpha 0.0057 0.0072 0.0178
Brugia malayi Inositol-1 0.0034 0.0027 0.0041
Onchocerca volvulus Huntingtin homolog 0.0109 0.0172 0.0278
Leishmania major succinyl-CoA synthetase alpha subunit, putative 0.0057 0.0072 0.0293
Schistosoma mansoni succinyl-CoA synthetase beta chain 0.0033 0.0025 0.0065
Loa Loa (eye worm) cathepsin B 0.0701 0.1317 0.1984
Leishmania major importin beta-1 subunit, putative 0.0022 0.0004 0.0016
Brugia malayi follicle stimulating hormone receptor 0.0215 0.0376 0.0567
Giardia lamblia Dipeptidyl-peptidase I precursor 0.021 0.0368 0.2796
Echinococcus multilocularis importin subunit beta 1 0.0027 0.0014 0.0014
Echinococcus granulosus cytochrome P450 2K1 0.0027 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.021 0.0368 0.095
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Onchocerca volvulus 0.0113 0.0181 0.0292
Brugia malayi succinyl-CoA ligase [GDP-forming] alpha-chain, mitochindrial 0.0057 0.0072 0.0108
Schistosoma mansoni Smad4 0.0027 0.0013 0.0034
Toxoplasma gondii cathepsin CPL 0.0923 0.1747 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.021 0.0368 0.2796
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0701 0.1317 0.5373
Leishmania major cysteine peptidase A (CPA) 0.0923 0.1747 0.7127
Brugia malayi Bromodomain containing protein 0.0034 0.0027 0.0041
Plasmodium falciparum succinyl-CoA synthetase alpha subunit, putative 0.0057 0.0072 0.0411
Giardia lamblia Cathepsin B precursor 0.021 0.0368 0.2796
Loa Loa (eye worm) carbonic anhydrase 3 0.1287 0.2451 0.3693
Echinococcus multilocularis succinyl coenzyme A ligase (GDP forming) subunit beta 0.0033 0.0025 0.0025
Trichomonas vaginalis succinate thiokinase a subunit 0.0057 0.0072 0.0411
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Trypanosoma cruzi cysteine peptidase, putative 0.0923 0.1747 0.5084
Chlamydia trachomatis succinyl-CoA ligase subunit alpha 0.0057 0.0072 1
Loa Loa (eye worm) hypothetical protein 0.1739 0.3324 0.5008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.021 0.0368 0.095
Loa Loa (eye worm) hypothetical protein 0.0289 0.052 0.0784
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0022 0.0004 0.0023
Brugia malayi Cathepsin L-like precursor 0.0634 0.1188 0.179
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0031 0.0047
Schistosoma mansoni cathepsin s 0.0289 0.052 0.1342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Trichomonas vaginalis importin beta-1, putative 0.0022 0.0004 0.0023
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0013 0.0013
Brugia malayi hypothetical protein 0.0113 0.0181 0.0272
Brugia malayi hypothetical protein 0.0047 0.0052 0.0078
Trichomonas vaginalis succinate thiokinase, beta subunit 0.0033 0.0025 0.0145
Leishmania major cytochrome p450-like protein 0.0058 0.0074 0.0301
Trichomonas vaginalis succinate thiokinase a subunit 0.0057 0.0072 0.0411
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.021 0.0368 0.2108
Trypanosoma cruzi cruzipain precursor, putative 0.0289 0.052 0.1514
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0068 0.0103
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0605 0.1131 0.1704
Entamoeba histolytica cysteine proteinase, putative 0.0499 0.0927 0.5307
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0289 0.052 0.0784
Entamoeba histolytica cysteine proteinase, putative 0.0634 0.1188 0.68
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0074 0.0111
Brugia malayi Papain family cysteine protease containing protein 0.021 0.0368 0.0555
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0133 0.0201
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0215 0.0376 0.0567
Entamoeba histolytica cysteine protease, putative 0.021 0.0368 0.2108
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0024 0.0007 0.0011
Trypanosoma cruzi succinyl-CoA ligase [GDP-forming] beta-chain, putative 0.0033 0.0025 0.0074
Giardia lamblia Cathepsin L precursor 0.021 0.0368 0.2796
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0031 0.0128
Trypanosoma cruzi cysteine peptidase, putative 0.0923 0.1747 0.5084
Plasmodium vivax serine-repeat antigen (SERA), putative 0.021 0.0368 0.2108
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0052 0.0061 0.0061
Mycobacterium ulcerans succinyl-CoA synthetase subunit beta 0.0033 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.0289 0.052 0.0784
Toxoplasma gondii ATP-citrate lyase, putative 0.0292 0.0525 0.3006
Plasmodium falciparum serine repeat antigen 6 0.021 0.0368 0.2108
Plasmodium falciparum serine repeat antigen 7 0.021 0.0368 0.2108
Loa Loa (eye worm) hypothetical protein 0.0038 0.0034 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Giardia lamblia Cathepsin L precursor 0.021 0.0368 0.2796
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0157 0.0265 0.1083
Brugia malayi acetyltransferase, GNAT family protein 0.0111 0.0176 0.0264
Loa Loa (eye worm) intermediate filament protein 0.0022 0.0003 0.0004
Plasmodium falciparum cysteine proteinase falcipain 3 0.0923 0.1747 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0499 0.0927 0.3782
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Onchocerca volvulus Matrilysin homolog 0.1427 0.2722 0.4471
Echinococcus multilocularis succinyl coenzyme A ligase (ADP forming) subunit beta 0.0033 0.0025 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Onchocerca volvulus Cathepsin L homolog 0.0923 0.1747 0.2867
Giardia lamblia Kinase, STE STE20 0.0157 0.0265 0.2015
Onchocerca volvulus 0.1427 0.2722 0.4471
Trypanosoma cruzi cysteine peptidase, putative 0.0923 0.1747 0.5084
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.021 0.0368 0.095
Trypanosoma brucei PAB1-binding protein , putative 0.0047 0.0052 0.0211
Echinococcus granulosus importin subunit beta 1 0.0027 0.0014 0.0014
Echinococcus granulosus GPCR family 2 0.0024 0.0007 0.0007
Brugia malayi MH2 domain containing protein 0.0027 0.0013 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Echinococcus multilocularis GPCR, family 2 0.0024 0.0007 0.0007
Loa Loa (eye worm) matrix metalloproteinase 0.1427 0.2722 0.4102
Echinococcus granulosus cathepsin l1 0.0634 0.1188 0.1188
Trichomonas vaginalis succinate thiokinase, beta subunit 0.0033 0.0025 0.0145
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0034 0.0027 0.0154
Schistosoma mansoni cathepsin F (C01 family) 0.0634 0.1188 0.3065
Trypanosoma cruzi succinyl-CoA synthetase alpha subunit, putative 0.0057 0.0072 0.0209
Plasmodium falciparum serine repeat antigen 3 0.021 0.0368 0.2108
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0032 0.0024 0.0024
Brugia malayi Bromodomain containing protein 0.0064 0.0086 0.0129
Plasmodium vivax serine-repeat antigen (SERA) 0.021 0.0368 0.2108
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0133 0.0201
Schistosoma mansoni hypothetical protein 0.0024 0.0007 0.0018
Onchocerca volvulus Cathepsin L homolog 0.0923 0.1747 0.2867
Toxoplasma gondii HEAT repeat-containing protein 0.0027 0.0014 0.0079
Onchocerca volvulus 0.0923 0.1747 0.2867
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0499 0.0927 0.2392
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.003 0.0018 0.0018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0075 0.0106 0.016
Brugia malayi intermediate filament protein 0.0022 0.0003 0.0004
Plasmodium falciparum importin beta, putative 0.0027 0.0014 0.0079
Loa Loa (eye worm) hypothetical protein 0.021 0.0368 0.0555
Loa Loa (eye worm) Smad1 0.0027 0.0013 0.002
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0157 0.0265 0.04
Echinococcus multilocularis dual specificity mitogen activated protein 0.0157 0.0265 0.0265
Entamoeba histolytica hypothetical protein 0.021 0.0368 0.2108
Giardia lamblia Histone acetyltransferase GCN5 0.0029 0.0018 0.0137
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0157 0.0265 0.04
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0013 0.0013
Loa Loa (eye worm) papain family cysteine protease containing protein 0.021 0.0368 0.0555
Plasmodium vivax unspecified product 0.0033 0.0025 0.0144
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.029 0.0522 0.0787
Entamoeba histolytica cysteine proteinase 1, putative 0.0499 0.0927 0.5307
Brugia malayi RNA, U transporter 1 0.0077 0.0111 0.0167
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.021 0.0368 0.2108
Echinococcus multilocularis carbonic anhydrase 0.0605 0.1131 0.1131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.021 0.0368 0.2108
Trypanosoma cruzi succinyl-CoA ligase [GDP-forming] beta-chain, putative 0.0033 0.0025 0.0074
Loa Loa (eye worm) acetyltransferase 0.0111 0.0176 0.0264
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0923 0.1747 1
Giardia lamblia Cathepsin L precursor 0.021 0.0368 0.2796
Trypanosoma cruzi citrate synthase, putative 0.0033 0.0025 0.0073
Mycobacterium leprae PROBABLE CITRATE SYNTHASE I GLTA2 0.0033 0.0025 0.0037
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.021 0.0368 0.2108
Entamoeba histolytica cysteine proteinase, putative 0.0499 0.0927 0.5307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0634 0.1188 0.68
Schistosoma mansoni succinyl-CoA synthetase beta chain 0.0021 0.0001 0.0003
Onchocerca volvulus 0.0634 0.1188 0.1948
Toxoplasma gondii LsmAD domain-containing protein 0.0047 0.0052 0.0296
Echinococcus granulosus lamin 0.0022 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0075 0.0106 0.016
Brugia malayi Matrixin family protein 0.1427 0.2722 0.4102
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0031 0.018
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Entamoeba histolytica cysteine protease, putative 0.021 0.0368 0.2108
Giardia lamblia Cysteine protease 0.021 0.0368 0.2796
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0013 0.0037
Mycobacterium leprae Probable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha) 0.0057 0.0072 0.0178
Brugia malayi Cathepsin L-like precursor 0.0923 0.1747 0.2632
Schistosoma mansoni inositol monophosphatase 0.0034 0.0027 0.007
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.021 0.0368 0.2108
Echinococcus multilocularis carbonic anhydrase II 0.1287 0.2451 0.2451
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.021 0.0368 0.2108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Toxoplasma gondii cathepsin CPC1 0.021 0.0368 0.2108
Leishmania major cytochrome p450-like protein 0.0027 0.0013 0.0052
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0499 0.0927 0.2392
Schistosoma mansoni smad1 5 8 and 0.0027 0.0013 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.021 0.0368 0.2108
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0047
Mycobacterium tuberculosis Conserved protein 0.0036 0.0031 0.0056
Plasmodium vivax unspecified product 0.0033 0.0025 0.0144
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Toxoplasma gondii succinate-Coenzyme A ligase, beta subunit, putative 0.0033 0.0025 0.0145
Schistosoma mansoni hypothetical protein 0.028 0.0503 0.1297
Schistosoma mansoni cytochrome P450 0.0027 0.0013 0.0033
Schistosoma mansoni intermediate filament proteins 0.0022 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0047
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Schistosoma mansoni hypothetical protein 0.029 0.0522 0.1348
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.0409 0.1196
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0031 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Mycobacterium tuberculosis Probable methylcitrate synthase PrpC 0.0033 0.0025 0.0037
Plasmodium vivax citrate synthase-like protein, putative 0.0033 0.0025 0.0144
Plasmodium vivax unspecified product 0.0499 0.0927 0.5307
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0111 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0032 0.0022 0.0034
Leishmania major cathepsin L-like protease 0.0923 0.1747 0.7127
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0034 0.0027 0.0004
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0157 0.0265 0.1083
Entamoeba histolytica cysteine proteinase, putative 0.0499 0.0927 0.5307
Echinococcus granulosus cathepsin L cysteine proteinase 0.0923 0.1747 0.1747
Plasmodium vivax unspecified product 0.0033 0.0025 0.0144
Trypanosoma cruzi cysteine protease, putative 0.0499 0.0927 0.2698
Loa Loa (eye worm) hypothetical protein 0.0634 0.1188 0.179
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1287 0.2451 0.3693
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0133 0.0343
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.021 0.0368 0.095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.021 0.0368 0.2108
Trypanosoma brucei succinyl-CoA synthetase alpha subunit, putative 0.0057 0.0072 0.0293
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1796 0.3436 0.8864
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0031 0.0031
Plasmodium vivax serine-repeat antigen (SERA) 0.021 0.0368 0.2108
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0013 0.002
Echinococcus granulosus succinyl coenzyme A ligase ADP forming subunit beta 0.0033 0.0025 0.0025
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0605 0.1131 0.1704
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0605 0.1131 0.1704
Echinococcus granulosus smad 0.0027 0.0013 0.0013
Trichomonas vaginalis STE family protein kinase 0.0157 0.0265 0.1519
Loa Loa (eye worm) latrophilin receptor protein 2 0.0024 0.0007 0.0011
Trichomonas vaginalis STE family protein kinase 0.0157 0.0265 0.1519
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0013 0.0013
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0034 0.0027 0.0154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Loa Loa (eye worm) hypothetical protein 0.0605 0.1131 0.1704
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0031 0.0056
Echinococcus granulosus cathepsin L 0.0499 0.0927 0.0927
Echinococcus multilocularis succinyl coenzyme A synthetase alpha subunit 0.0057 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0605 0.1131 0.1704
Plasmodium vivax succinyl-CoA synthetase alpha subunit, putative 0.0057 0.0072 0.0411
Echinococcus granulosus carbonic anhydrase 0.0605 0.1131 0.1131
Brugia malayi Papain family cysteine protease containing protein 0.021 0.0368 0.0555
Loa Loa (eye worm) hypothetical protein 0.0047 0.0052 0.0078
Echinococcus multilocularis cathepsin b 0.1796 0.3436 0.3436
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0923 0.1747 0.2632
Brugia malayi ATP-citrate synthase 0.0292 0.0525 0.0791
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Loa Loa (eye worm) succinate-CoA ligase 0.0033 0.0025 0.0038
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.021 0.0368 0.095
Echinococcus multilocularis 0.0027 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0289 0.052 0.1514
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0289 0.052 0.0784
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0923 0.1747 0.1747
Trypanosoma cruzi PAB1-binding protein , putative 0.0047 0.0052 0.015
Brugia malayi Cathepsin L-like precursor 0.0923 0.1747 0.2632
Plasmodium falciparum ataxin-2 like protein, putative 0.0047 0.0052 0.0296
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0031 0.0047
Brugia malayi MH2 domain containing protein 0.0395 0.0725 0.1092
Loa Loa (eye worm) hypothetical protein 0.0045 0.0048 0.0072
Plasmodium vivax citrate synthase, mitochondrial precursor, putative 0.0033 0.0025 0.0144
Onchocerca volvulus Huntingtin homolog 0.0109 0.0172 0.0278
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0605 0.1131 0.1704
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0034 0.0027 0.0043
Onchocerca volvulus 0.0036 0.0031 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Brugia malayi Intermediate filament tail domain containing protein 0.0022 0.0003 0.0004
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0634 0.1188 0.3457
Brugia malayi MH1 domain containing protein 0.0027 0.0013 0.002
Mycobacterium tuberculosis Probable succinyl-CoA synthetase (beta chain) SucC (SCS-beta) 0.0033 0.0025 0.0038
Leishmania major cytochrome p450-like protein 0.0027 0.0013 0.0052
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0047
Schistosoma mansoni hypothetical protein 0.0024 0.0007 0.0018
Echinococcus multilocularis cysteine protease 0.0923 0.1747 0.1747
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0031 0.018
Trypanosoma brucei cytochrome P450, putative 0.0058 0.0074 0.0301
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0032 0.0024 0.0137
Echinococcus multilocularis cathepsin L cysteine protease 0.0923 0.1747 0.1747
Giardia lamblia Hypothetical protein 0.021 0.0368 0.2796
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0031 0.0091
Echinococcus granulosus lamin dm0 0.0022 0.0003 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0923 0.1747 0.7127
Echinococcus multilocularis lamin dm0 0.0022 0.0003 0.0003
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0032 0.0024 0.0069
Onchocerca volvulus 0.0923 0.1747 0.2867
Schistosoma mansoni cathepsin F (C01 family) 0.0923 0.1747 0.4507
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0013 0.0037
Loa Loa (eye worm) hypothetical protein 0.0923 0.1747 0.2632
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Loa Loa (eye worm) hypothetical protein 0.021 0.0368 0.0555
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0034 0.0027 0.0155
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0032 0.0024 0.0069
Leishmania major hypothetical protein, conserved 0.0032 0.0024 0.0097
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0022 0.0003 0.0004
Entamoeba histolytica papain family cysteine protease domain containing protein 0.021 0.0368 0.2108
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0605 0.1131 0.1704
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0034 0.0027 0.0155
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.021 0.0368 0.2108
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.021 0.0368 0.2108
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.2715 0.5213 1
Brugia malayi Importin beta-1 subunit 0.0027 0.0014 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0133 0.0133
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0034 0.0027 0.0155
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0499 0.0927 0.2698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0034 0.0027 0.0111
Schistosoma mansoni hypothetical protein 0.0605 0.1131 0.2918
Entamoeba histolytica cysteine proteinase, putative 0.0499 0.0927 0.5307
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0027 0.0013 0.0052
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0024 0.0007 0.0007
Toxoplasma gondii Erv1 / Alr family protein 0.0032 0.0024 0.0137
Loa Loa (eye worm) beta-lactamase 0.0036 0.0031 0.0047
Entamoeba histolytica papain family cysteine protease domain containing protein 0.021 0.0368 0.2108
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0923 0.1747 1
Onchocerca volvulus 0.0057 0.0072 0.0113
Loa Loa (eye worm) hypothetical protein 0.0051 0.006 0.0091
Loa Loa (eye worm) hypothetical protein 0.0109 0.0172 0.0259
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.021 0.0368 0.0555
Schistosoma mansoni hypothetical protein 0.0051 0.006 0.0155
Echinococcus granulosus survival motor neuron protein 1 0.0178 0.0305 0.0305
Trypanosoma cruzi PAB1-binding protein , putative 0.0047 0.0052 0.015
Echinococcus granulosus intermediate filament protein 0.0022 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0923 0.1747 1
Entamoeba histolytica cysteine protease, putative 0.0499 0.0927 0.5307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0923 0.1747 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.021 0.0368 0.2108
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0075 0.0106 0.016
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1796 0.3436 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0701 0.1317 0.7539
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0031 0.0056
Trypanosoma brucei succinyl-CoA ligase [GDP-forming] beta-chain, putative 0.0033 0.0025 0.0103
Brugia malayi Matrixin family protein 0.3452 0.6637 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0499 0.0927 0.2392
Loa Loa (eye worm) hypothetical protein 0.1427 0.2722 0.4102
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0032 0.0024 0.0137
Giardia lamblia Cysteine protease 0.021 0.0368 0.2796
Schistosoma mansoni cathepsin F (C01 family) 0.0923 0.1747 0.4507
Schistosoma mansoni cathepsin S (C01 family) 0.021 0.0368 0.095
Brugia malayi Matrixin family protein 0.1427 0.2722 0.4102
Echinococcus granulosus carbonic anhydrase II 0.1287 0.2451 0.2451
Giardia lamblia Cathepsin B precursor 0.021 0.0368 0.2796
Trypanosoma cruzi major cysteine proteinase, putative 0.021 0.0368 0.1072
Trypanosoma cruzi cysteine proteinase, putative 0.0499 0.0927 0.2698
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.021 0.0368 0.2108
Echinococcus multilocularis cathepsin L 0.0499 0.0927 0.0927
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.021 0.0368 0.2108
Brugia malayi Cathepsin L-like precursor 0.0923 0.1747 0.2632
Brugia malayi Probable citrate synthase, mitochondrial precursor, putative 0.0033 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.0109 0.0172 0.0259
Loa Loa (eye worm) inositol-1 0.0034 0.0027 0.0041
Brugia malayi Cytochrome P450 family protein 0.0058 0.0074 0.0111
Brugia malayi Papain family cysteine protease containing protein 0.0923 0.1747 0.2632
Plasmodium falciparum citrate synthase-like protein, putative 0.0033 0.0025 0.0144
Plasmodium falciparum ataxin-2 like protein, putative 0.0047 0.0052 0.0296
Brugia malayi latrophilin 2 splice variant baaae 0.0051 0.006 0.0091
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0031 0.018
Trichomonas vaginalis bromodomain-containing protein, putative 0.0034 0.0027 0.0154

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.59 uM Inhibition of p53-binding to HDM2 (human MDM2) by fluorescence polarization peptide displacement assay ChEMBL. 15664854
IC50 (binding) = 1.59 uM Inhibition of p53-binding to HDM2 (human MDM2) by fluorescence polarization peptide displacement assay ChEMBL. 15664854
Kd = 0.167 uM Dissociation constant of the compound was determined; (by measuring difference in protein melting temperature) ChEMBL. 15664854

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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