Detailed information for compound 344195

Basic information

Technical information
  • TDR Targets ID: 344195
  • Name: 4-(4-chlorophenyl)-1-(4,4-diphenylbutyl)piper idin-4-ol
  • MW: 419.986 | Formula: C27H30ClNO
  • H donors: 1 H acceptors: 1 LogP: 6.17 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C1(O)CCN(CC1)CCCC(c1ccccc1)c1ccccc1
  • InChi: 1S/C27H30ClNO/c28-25-15-13-24(14-16-25)27(30)17-20-29(21-18-27)19-7-12-26(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-6,8-11,13-16,26,30H,7,12,17-21H2
  • InChiKey: LLQCATMGHGFZSS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-chlorophenyl)-1-(4,4-diphenylbutyl)-4-piperidinol
  • 4-(4-chlorophenyl)-1-[4,4-di(phenyl)butyl]piperidin-4-ol
  • 4-(4-chlorophenyl)-1-[4,4-di(phenyl)butyl]-4-piperidinol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) Human herpesvirus 5 chemokine receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Human herpesvirus 5 chemokine receptor   354 aa 306 aa 25.8 %
Echinococcus multilocularis allatostatin A receptor Human herpesvirus 5 chemokine receptor   354 aa 334 aa 24.3 %
Onchocerca volvulus Human herpesvirus 5 chemokine receptor   354 aa 320 aa 22.2 %
Echinococcus multilocularis neuropeptide receptor Human herpesvirus 5 chemokine receptor   354 aa 304 aa 24.3 %
Onchocerca volvulus Human herpesvirus 5 chemokine receptor   354 aa 299 aa 20.7 %
Echinococcus granulosus thyrotropin releasing hormone receptor Human herpesvirus 5 chemokine receptor   354 aa 339 aa 19.8 %
Loa Loa (eye worm) hypothetical protein Human herpesvirus 5 chemokine receptor   354 aa 295 aa 24.4 %
Schistosoma mansoni adenoreceptor Human herpesvirus 5 chemokine receptor   354 aa 329 aa 23.4 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Human herpesvirus 5 chemokine receptor   354 aa 327 aa 20.5 %
Onchocerca volvulus Human herpesvirus 5 chemokine receptor   354 aa 286 aa 23.4 %
Loa Loa (eye worm) neuropeptide F receptor Human herpesvirus 5 chemokine receptor   354 aa 318 aa 22.6 %
Brugia malayi putative neuropeptide receptor NPR1 Human herpesvirus 5 chemokine receptor   354 aa 294 aa 23.8 %
Echinococcus granulosus allatostatin A receptor Human herpesvirus 5 chemokine receptor   354 aa 337 aa 24.0 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Human herpesvirus 5 chemokine receptor   354 aa 330 aa 27.0 %
Onchocerca volvulus Human herpesvirus 5 chemokine receptor   354 aa 324 aa 25.0 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Human herpesvirus 5 chemokine receptor   354 aa 339 aa 19.5 %
Onchocerca volvulus Human herpesvirus 5 chemokine receptor   354 aa 293 aa 23.5 %
Schistosoma mansoni peptide (allatostatin)-like receptor Human herpesvirus 5 chemokine receptor   354 aa 307 aa 24.4 %
Schistosoma mansoni opsin-like receptor Human herpesvirus 5 chemokine receptor   354 aa 328 aa 24.1 %
Echinococcus granulosus neuropeptide receptor Human herpesvirus 5 chemokine receptor   354 aa 304 aa 24.7 %
Onchocerca volvulus Human herpesvirus 5 chemokine receptor   354 aa 294 aa 25.5 %
Onchocerca volvulus Phospholipase d-related homolog Human herpesvirus 5 chemokine receptor   354 aa 310 aa 22.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.1607 0.2917 0.2917
Loa Loa (eye worm) hypothetical protein 0.0026 0.001 0.001
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0095 0.1114
Echinococcus granulosus fetal alzheimer antigen falz 0.0051 0.0055 0.0088
Mycobacterium tuberculosis Conserved protein 0.0075 0.01 0.1175
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Loa Loa (eye worm) hypothetical protein 0.5123 0.9379 0.9379
Plasmodium vivax geranylgeranyltransferase, putative 0.0371 0.0644 0.1025
Onchocerca volvulus 0.0309 0.0531 0.182
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0095 0.015
Schistosoma mansoni transient receptor potential channel 0.0046 0.0047 0.0075
Echinococcus multilocularis muscleblind protein 1 0.0156 0.025 0.0399
Loa Loa (eye worm) hypothetical protein 0.0842 0.151 0.151
Echinococcus multilocularis cpg binding protein 0.0096 0.0138 0.022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0766 0.137 0.137
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.3428 0.6265 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0479 0.0843 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0096 0.0154
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Onchocerca volvulus 0.0021 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0069 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0048 0.005 0.008
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.3428 0.6265 1
Schistosoma mansoni nAChR subunit 0.1607 0.2917 0.4657
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0371 0.0644 0.1025
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.1607 0.2917 0.4657
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.254 0.4631 0.7391
Schistosoma mansoni hypothetical protein 0.0353 0.0611 0.0975
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0056 0.009
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0119 0.0182 0.0288
Loa Loa (eye worm) hypothetical protein 0.0156 0.025 0.025
Trypanosoma cruzi polyprenyl synthase, putative 0.003 0.0018 0.0068
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0152 0.0152
Mycobacterium leprae Probable lipase LipE 0.0075 0.01 1
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.1324 0.2396 0.3823
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0029 0.0047
Onchocerca volvulus 0.1607 0.2917 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0766 0.137 0.137
Trypanosoma cruzi polyprenyl synthase, putative 0.003 0.0018 0.0068
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0044 0.0177
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0052 0.0082
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0766 0.137 0.2187
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0184 0.03 0.048
Schistosoma mansoni zinc finger protein 0.0048 0.0051 0.0082
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0029 0.0047
Echinococcus granulosus short transient receptor potential channel 6 0.0046 0.0047 0.0075
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.0059
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0036 0.0055
Loa Loa (eye worm) hypothetical protein 0.0095 0.0137 0.0137
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0001 0.0001
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0114 0.0172 0.0274
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.0422 0.0673
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0315 0.0541 0.2252
Loa Loa (eye worm) hypothetical protein 0.0075 0.01 0.01
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.01 0.016
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.003 0.0018 0.0026
Loa Loa (eye worm) hypothetical protein 0.0075 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0026 0.001 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0056 0.0651
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0056 0.009
Echinococcus multilocularis glycine receptor subunit alpha 1 0.1607 0.2917 0.4657
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0095 0.9481
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0119 0.0182 0.029
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0026 0.0041
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.1607 0.2917 0.2917
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.1607 0.2917 0.4657
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.1607 0.2917 0.4657
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.1607 0.2917 0.4657
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.1324 0.2396 0.3823
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0017 0.0035
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.003 0.0018 0.0028
Leishmania major lanosterol synthase, putative 0.0048 0.0051 0.0205
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.1607 0.2917 0.2917
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.01 0.1175
Loa Loa (eye worm) hypothetical protein 0.0075 0.01 0.01
Brugia malayi hypothetical protein 0.0025 0.0008 0.0008
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.01 0.01
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0035 0.0035
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0086 0.0121 0.0121
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.1607 0.2917 0.4657
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0056 0.0651
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Onchocerca volvulus 0.0766 0.137 0.4697
Brugia malayi beta-lactamase family protein 0.0075 0.01 0.01
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0001 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.01 0.0158
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0026 0.0041
Loa Loa (eye worm) hypothetical protein 0.546 1 1
Schistosoma mansoni bromodomain containing protein 0.0137 0.0214 0.0341
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.01 0.0158
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0889 0.1596 0.2548
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.01 0.0158
Echinococcus multilocularis microtubule associated protein 2 0.0719 0.1284 0.2049
Brugia malayi Polyprenyl synthetase family protein 0.003 0.0018 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0056 0.0651
Brugia malayi Cation transporter family protein 0.1607 0.2917 0.2917
Echinococcus granulosus voltage dependent calcium channel subunit 0.0261 0.0442 0.0706
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.1607 0.2917 0.4657
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0371 0.0644 0.1027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0056 0.009
Schistosoma mansoni acetylcholine receptor-related 0.0766 0.137 0.2187
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0315 0.0541 0.2252
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0371 0.0644 0.1027
Trypanosoma cruzi ISWI complex protein 0.0031 0.0019 0.0075
Schistosoma mansoni acetylcholine receptor subunit beta 0.0766 0.137 0.2187
Schistosoma mansoni transient receptor potential channel 4 0.0069 0.009 0.0144
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.1324 0.2396 0.3823
Echinococcus multilocularis GPCR, family 2 0.0048 0.005 0.008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0002 0.0003
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.013 0.02 0.032
Echinococcus granulosus geminin 0.0353 0.0611 0.0975
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.004 0.0062
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.3428 0.6265 1
Schistosoma mansoni nAChR subunit 0.0766 0.137 0.2187
Echinococcus granulosus glycine receptor subunit beta 0.1607 0.2917 0.4657
Echinococcus granulosus short transient receptor potential channel 6 0.0046 0.0047 0.0075
Loa Loa (eye worm) hypothetical protein 0.0842 0.151 0.151
Onchocerca volvulus 0.0087 0.0122 0.0417
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0062 1
Onchocerca volvulus 0.0842 0.151 0.5174
Trypanosoma cruzi hypothetical protein, conserved 0.0371 0.0644 0.2682
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0371 0.0644 0.1027
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0766 0.137 0.137
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0236 0.098
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0889 0.1596 0.2548
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.1607 0.2917 0.2917
Loa Loa (eye worm) GABA receptor subunit 0.0842 0.151 0.151
Loa Loa (eye worm) LGC-31 protein 0.1607 0.2917 0.2917
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0017 0.0067
Onchocerca volvulus 0.0021 0.0001 0.0005
Echinococcus multilocularis nAChR subunit 0.1607 0.2917 0.4657
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.2833 0.5171 0.8254
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.3428 0.6265 1
Echinococcus granulosus glycine receptor subunit beta 0.1607 0.2917 0.4657
Echinococcus granulosus transient receptor potential gamma protein 0.0069 0.009 0.0144
Giardia lamblia Farnesyl diphosphate synthase 0.0119 0.0182 0.0234
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.1607 0.2917 0.4657
Brugia malayi Cation transporter family protein 0.1607 0.2917 0.2917
Schistosoma mansoni hypothetical protein 0.1235 0.2233 0.3564
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.01 0.1175
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0371 0.0644 0.1025
Schistosoma mansoni nAChR subunit 0.1607 0.2917 0.4657
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0766 0.137 0.137
Loa Loa (eye worm) hypothetical protein 0.0156 0.025 0.025
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0051 0.0055 0.0088
Loa Loa (eye worm) acetylcholine receptor protein 0.0766 0.137 0.137
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.0267 0.3155
Giardia lamblia Prenyltransferase 0.1324 0.2396 0.3789
Leishmania major hypothetical protein, conserved 0.0031 0.0019 0.0075
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Loa Loa (eye worm) hypothetical protein 0.0151 0.0239 0.0239
Schistosoma mansoni nAChR subunit 0.1607 0.2917 0.4657
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.3428 0.6265 0.6265
Loa Loa (eye worm) hypothetical protein 0.0103 0.0152 0.0152
Schistosoma mansoni hypothetical protein 0.0319 0.0549 0.0876
Echinococcus granulosus cpg binding protein 0.0096 0.0138 0.022
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Schistosoma mansoni protein farnesyltransferase subunit beta 0.1324 0.2396 0.3824
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0371 0.0644 0.1025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.0239 0.0239
Echinococcus multilocularis glycine receptor subunit alpha 1 0.1607 0.2917 0.4657
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0889 0.1596 0.1596
Echinococcus multilocularis nAChR subunit 0.0842 0.151 0.241
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0095 0.0095
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.1607 0.2917 0.4657
Brugia malayi excitatory GABA receptor EXP-1A 0.1607 0.2917 0.2917
Trypanosoma cruzi protein farnesyltransferase, putative 0.1324 0.2396 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0119 0.0182 0.2143
Trypanosoma cruzi lanosterol synthase, putative 0.0419 0.0732 0.3051
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0002 0.0003
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0419 0.0732 0.8677
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0029 0.0047
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Trypanosoma cruzi hypothetical protein, conserved 0.0889 0.1596 0.6661
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0153 0.0244 0.039
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0842 0.151 0.151
Loa Loa (eye worm) hypothetical protein 0.0842 0.151 0.151
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.1607 0.2917 0.4657
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.003 0.0018 0.0026
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0008 0.0011
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0371 0.0644 0.2682
Brugia malayi CHE-14 protein 0.0042 0.004 0.004
Plasmodium falciparum protein farnesyltransferase subunit beta 0.1324 0.2396 0.3823
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0119 0.0182 0.0288
Plasmodium vivax farnesyltransferase beta subunit, putative 0.1324 0.2396 0.3823
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0008 0.0028
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0221 0.0352
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0095 0.3531
Echinococcus granulosus glycine receptor subunit alpha 1 0.1607 0.2917 0.4657
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.3428 0.6265 1
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0371 0.0644 0.0644
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0062 0.0715
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.005 0.005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.01 0.3724
Trypanosoma brucei lanosterol synthase 0.0419 0.0732 0.3051
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0075 0.01 0.0413
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.003 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0072 0.0095 0.0095
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0052 0.008
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0889 0.1596 0.2548
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0001 0.0002
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.3428 0.6265 1
Brugia malayi Cytochrome P450 family protein 0.0047 0.005 0.005
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.004 0.0064
Schistosoma mansoni nAChR subunit 0.1607 0.2917 0.4657
Onchocerca volvulus 0.0889 0.1596 0.5472
Loa Loa (eye worm) ACC-1 protein 0.1607 0.2917 0.2917
Brugia malayi hypothetical protein 0.0071 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0842 0.151 0.151
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0044 0.0177
Schistosoma mansoni zinc finger protein 0.0031 0.0019 0.0031
Brugia malayi Bromodomain containing protein 0.0081 0.0112 0.0112
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.01 0.016
Schistosoma mansoni transient receptor potential channel 0.0046 0.0047 0.0075
Loa Loa (eye worm) beta-lactamase 0.0075 0.01 0.01
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0052 0.0108
Loa Loa (eye worm) hypothetical protein 0.0842 0.151 0.151
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0889 0.1596 0.6661
Brugia malayi MH2 domain containing protein 0.0122 0.0187 0.0187
Schistosoma mansoni hypothetical protein 0.0048 0.005 0.008
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0766 0.137 0.2187
Giardia lamblia Rab geranylgeranyltransferase 0.3428 0.6265 1
Entamoeba histolytica hypothetical protein 0.0071 0.0093 0.0147
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0051 0.0055 0.0088
Plasmodium vivax prenyltransferase alpha subunit, putative 0.3428 0.6265 1
Echinococcus multilocularis importin subunit beta 1 0.003 0.0017 0.0028
Trypanosoma cruzi protein farnesyltransferase, putative 0.1324 0.2396 1
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.003 0.0018 0.0026
Onchocerca volvulus 0.0072 0.0095 0.0326
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0008 0.0011
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.1607 0.2917 0.4657
Leishmania major farnesyl pyrophosphate synthase 0.0119 0.0182 0.0754
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.1324 0.2396 0.5172
Brugia malayi CXXC zinc finger family protein 0.0087 0.0122 0.0122
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0095 0.1114
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0001 0.0001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1607 0.2917 0.2917
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0095 0.0095
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0056 0.0056
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.003 0.0018 0.0068
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0842 0.151 0.241
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.1607 0.2917 0.2917
Schistosoma mansoni hypothetical protein 0.0071 0.0093 0.0149
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Loa Loa (eye worm) hypothetical protein 0.025 0.0422 0.0422
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.1607 0.2917 0.2917
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.1607 0.2917 0.4657
Brugia malayi Muscleblind-like protein 0.0156 0.025 0.025
Onchocerca volvulus 0.1607 0.2917 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.01 0.01
Echinococcus granulosus expressed conserved protein 0.0092 0.0132 0.0211
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.1607 0.2917 0.2917
Echinococcus multilocularis zinc finger protein 0.0048 0.0051 0.0082
Trypanosoma cruzi solanesyl-diphosphate synthase 0.003 0.0018 0.0068
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.005 0.005
Mycobacterium ulcerans hypothetical protein 0.0072 0.0095 0.3531
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.0228 0.0364
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0146 0.0233
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.003 0.0018 0.0028
Echinococcus multilocularis expressed conserved protein 0.0092 0.0132 0.0211
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.3428 0.6265 1
Echinococcus granulosus zinc finger protein 0.0048 0.0051 0.0082
Brugia malayi hypothetical protein 0.0766 0.137 0.137
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.005 0.008
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.004 0.004
Onchocerca volvulus 0.0021 0.0001 0.0005
Toxoplasma gondii hypothetical protein 0.0889 0.1596 0.3445
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0012 0.0019
Leishmania major hypothetical protein, conserved 0.0025 0.0008 0.0028
Echinococcus multilocularis short transient receptor potential channel 6 0.0046 0.0047 0.0075
Loa Loa (eye worm) hypothetical protein 0.0048 0.005 0.005
Mycobacterium ulcerans lipase LipD 0.0075 0.01 0.3724
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0008 0.0028
Schistosoma mansoni polycystin 1-related 0.0191 0.0314 0.05
Echinococcus granulosus survival motor neuron protein 1 0.025 0.0422 0.0673
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1607 0.2917 0.2917
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.1607 0.2917 0.2917
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0062 0.0096
Trypanosoma brucei ISWI complex protein 0.0031 0.0019 0.0075
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0095 0.3531
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.01 0.0413
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0371 0.0644 0.1025
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.003 0.0018 0.0028
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.1607 0.2917 0.4657
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0889 0.1596 0.2546
Loa Loa (eye worm) hypothetical protein 0.0075 0.01 0.01
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0096 0.0154
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0057 0.0068 0.0108
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.1607 0.2917 0.4657
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0889 0.1596 0.6661
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.003 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0056 0.009
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0766 0.137 0.137
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0119 0.0182 0.0754
Brugia malayi hypothetical protein 0.0766 0.137 0.137
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0012 0.0019
Brugia malayi Bromodomain containing protein 0.0161 0.0257 0.0257
Schistosoma mansoni hypothetical protein 0.0048 0.005 0.008
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.1607 0.2917 0.2917
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0044 0.0177
Entamoeba histolytica hypothetical protein 0.0842 0.151 0.2408
Toxoplasma gondii histone lysine methyltransferase SET1 0.0173 0.028 0.0602
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.003 0.0018 0.0026
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.003 0.0018 0.0617
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.3428 0.6265 0.6265
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0143 0.0143
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0119 0.0182 0.0754
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.004 0.0064
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0039 0.0039
Schistosoma mansoni microtubule-associated protein tau 0.0719 0.1284 0.2049
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.0059
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.1607 0.2917 0.4657
Onchocerca volvulus 0.0075 0.01 0.0344
Onchocerca volvulus 0.0051 0.0056 0.0192
Loa Loa (eye worm) hypothetical protein 0.0143 0.0226 0.0226
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0889 0.1596 0.6661
Brugia malayi Transient-receptor-potential like protein 0.0026 0.001 0.001
Onchocerca volvulus 0.1607 0.2917 1
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.1324 0.2396 0.2396
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0018 0.0018
Trichomonas vaginalis esterase, putative 0.0075 0.01 0.0158
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0766 0.137 0.2187
Schistosoma mansoni nAChR subunit 0.1607 0.2917 0.4657
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0842 0.151 0.151
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.1607 0.2917 0.2917
Leishmania major solanesyl-diphosphate synthase, putative 0.003 0.0018 0.0068
Toxoplasma gondii hypothetical protein 0.0051 0.0056 0.0117
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.1324 0.2396 0.3823
Loa Loa (eye worm) hypothetical protein 0.0072 0.0095 0.0095
Echinococcus multilocularis short transient receptor potential channel 6 0.0046 0.0047 0.0075
Schistosoma mansoni cpg binding protein 0.0096 0.0138 0.022
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0119 0.0182 0.039
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.01 0.1175
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.003 0.0018 0.0068
Echinococcus multilocularis glycine receptor subunit beta 0.1607 0.2917 0.4657
Echinococcus granulosus glycine receptor subunit alpha 1 0.1607 0.2917 0.4657
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0095 0.3531
Loa Loa (eye worm) hypothetical protein 0.0044 0.0043 0.0043
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0061 0.0251
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.005 0.005
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0036 0.0055
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0056 0.009
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0029 0.0047
Loa Loa (eye worm) hypothetical protein 0.0309 0.0531 0.0531
Echinococcus granulosus TRP transient receptor potential channel 0.0026 0.001 0.0016
Brugia malayi Cation transporter family protein 0.1607 0.2917 0.2917
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Loa Loa (eye worm) hypothetical protein 0.4694 0.8592 0.8592
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.1607 0.2917 0.2917
Echinococcus multilocularis snurportin 1 0.0319 0.0549 0.0876
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.1607 0.2917 0.2917
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0261 0.0442 0.0706
Echinococcus granulosus microtubule associated protein 2 0.0719 0.1284 0.2049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.0239 0.0239
Loa Loa (eye worm) ACC-1 protein 0.1607 0.2917 0.2917
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.3428 0.6265 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0095 0.3531
Echinococcus granulosus voltage dependent calcium channel subunit 0.0119 0.0181 0.0288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0056 0.009
Trypanosoma brucei hypothetical protein, conserved 0.0889 0.1596 0.6661
Echinococcus granulosus GPCR family 2 0.0048 0.005 0.008
Brugia malayi Importin beta-1 subunit 0.003 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0054 0.0062 0.0062
Brugia malayi Polyprenyl synthetase family protein 0.0119 0.0182 0.0182
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0062 0.0096
Schistosoma mansoni hypothetical protein 0.0061 0.0075 0.012
Brugia malayi beta-lactamase 0.0075 0.01 0.01
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0062 0.2267
Loa Loa (eye worm) hypothetical protein 0.0075 0.01 0.01
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0766 0.137 0.137
Echinococcus granulosus glycine receptor subunit alpha 1 0.1607 0.2917 0.4657
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.003 0.0018 0.1658
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0029
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0008 0.0011
Onchocerca volvulus 0.0075 0.01 0.0344
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.1324 0.2396 0.2396
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.01 0.1175
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.004
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.1324 0.2396 0.3823
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.1607 0.2917 0.2917
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0766 0.137 0.137
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0889 0.1596 0.6661
Plasmodium falciparum importin beta, putative 0.003 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.003 0.0017 0.0017
Schistosoma mansoni nAChR subunit 0.0766 0.137 0.2187
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0371 0.0644 0.0644
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0953 0.1715 0.2735
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0001 0.0002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0056 0.0056
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0371 0.0644 0.1027
Onchocerca volvulus 0.1607 0.2917 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.0051 0.0081
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.1324 0.2396 0.3824
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0371 0.0644 0.1025
Onchocerca volvulus Putative nachr subunit 0.1607 0.2917 1
Brugia malayi hypothetical protein 0.025 0.0422 0.0422
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0187 0.0187
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0007 0.0023
Loa Loa (eye worm) hypothetical protein 0.0098 0.0143 0.0143
Schistosoma mansoni survival motor neuron protein 0.0051 0.0056 0.009
Schistosoma mansoni importin beta-1 0.003 0.0017 0.0028
Schistosoma mansoni hypothetical protein 0.0048 0.005 0.008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.005 0.008
Echinococcus granulosus dnaJ subfamily B 0.1235 0.2233 0.3564
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0153 0.0244 0.039
Entamoeba histolytica hypothetical protein 0.0071 0.0093 0.0147
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.0549 0.0549
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1607 0.2917 0.2917
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0119 0.0181 0.0288
Echinococcus granulosus nAChR subunit 0.1607 0.2917 0.4657
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0042 0.0039 0.0063
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.003 0.0018 0.0035
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.01 0.3724
Trypanosoma cruzi lanosterol synthase, putative 0.0419 0.0732 0.3051
Schistosoma mansoni hypothetical protein 0.0051 0.0056 0.009
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0054 0.0062 0.0062
Echinococcus granulosus Protein patched homolog 1 0.0042 0.004 0.0064
Echinococcus granulosus nAChR subunit 0.0842 0.151 0.241
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0052 0.0108
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0842 0.151 0.151
Brugia malayi Cache domain containing protein 0.0053 0.0059 0.0059
Brugia malayi RNA, U transporter 1 0.0085 0.0119 0.0119
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.2173 0.3957 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0766 0.137 0.2187
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0095 0.3531
Trypanosoma cruzi hypothetical protein, conserved 0.0371 0.0644 0.2682
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0371 0.0644 0.1025
Loa Loa (eye worm) polyprenyl synthetase 0.0119 0.0182 0.0182
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.003 0.0018 0.0617
Echinococcus multilocularis glycine receptor subunit beta 0.1607 0.2917 0.4657
Giardia lamblia Rab geranylgeranyltransferase 0.0371 0.0644 0.0975
Loa Loa (eye worm) hypothetical protein 0.0054 0.0062 0.0062
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0889 0.1596 0.2546
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.1607 0.2917 0.4657
Brugia malayi beta-lactamase family protein 0.0075 0.01 0.01
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0075 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0093 0.0149
Brugia malayi hypothetical protein 0.0766 0.137 0.137
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0052 0.008
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.1607 0.2917 0.4657
Schistosoma mansoni neurotransmitter gated ion channel 0.0842 0.151 0.241
Schistosoma mansoni patched 1 0.0042 0.004 0.0064
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.01 0.0158
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.247 0.4503 0.7187
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0052 0.008
Echinococcus multilocularis transient receptor potential ion channel A 0.0067 0.0086 0.0137
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.01 0.1175
Mycobacterium tuberculosis Conserved protein 0.0075 0.01 0.1175
Schistosoma mansoni trans-prenyltransferase 0.003 0.0018 0.0028
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0119 0.0182 0.6794
Loa Loa (eye worm) hypothetical protein 0.0842 0.151 0.151
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0766 0.137 0.2187
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.003 0.0018 0.0195
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1607 0.2917 0.2917
Onchocerca volvulus 0.1607 0.2917 1
Leishmania major farnesyltransferase beta subunit 0.1324 0.2396 1
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.1324 0.2396 0.3823
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0002 0.0003
Leishmania major mitochondrial DNA polymerase beta 0.0315 0.0541 0.2252
Loa Loa (eye worm) hypothetical protein 0.0052 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.1607 0.2917 0.4657
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.01 0.0158
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.1324 0.2396 0.3823
Schistosoma mansoni nAChR subunit 0.1607 0.2917 0.4657
Loa Loa (eye worm) hypothetical protein 0.0054 0.0062 0.0062
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0119 0.0182 0.0288
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Loa Loa (eye worm) hypothetical protein 0.0371 0.0644 0.0644
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0026 0.0041
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.0239 0.0239
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.1607 0.2917 0.4657
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0056 0.0651
Echinococcus granulosus muscleblind protein 0.0156 0.025 0.0399
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0371 0.0644 0.0644
Echinococcus multilocularis muscleblind protein 0.0156 0.025 0.0399
Mycobacterium ulcerans beta-lactamase 0.0075 0.01 0.3724
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.01 0.016
Brugia malayi acetyltransferase, GNAT family protein 0.0153 0.0244 0.0244
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.01 0.1175
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.003 0.0018 0.0195
Brugia malayi Latrophilin receptor protein 2 0.0048 0.005 0.005
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0371 0.0644 0.1025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0093 0.0149
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0143 0.0228
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0095 0.015
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.003 0.0018 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.01 0.0413
Loa Loa (eye worm) hypothetical protein 0.0053 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0371 0.0644 0.1027
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0095 0.3531
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0889 0.1596 0.2546
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0119 0.0182 0.6794
Onchocerca volvulus 0.0766 0.137 0.4697
Schistosoma mansoni serine-rich repeat protein 0.0061 0.0075 0.012
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0371 0.0644 0.1387
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0095 0.9481
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.003 0.0018 0.0195
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0119 0.0182 0.029
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.003 0.0018 0.0068
Trypanosoma brucei protein farnesyltransferase beta subunit 0.1324 0.2396 1
Schistosoma mansoni hypothetical protein 0.0353 0.0611 0.0975
Mycobacterium ulcerans hypothetical protein 0.0075 0.01 0.3724
Trypanosoma cruzi ISWI complex protein 0.0031 0.0019 0.0075
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0842 0.151 0.241
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0119 0.0182 0.0288
Brugia malayi hypothetical protein 0.0766 0.137 0.137
Loa Loa (eye worm) hypothetical protein 0.0054 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0842 0.151 0.151
Loa Loa (eye worm) hypothetical protein 0.0842 0.151 0.151
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1607 0.2917 0.2917
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0095 0.3531
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0002 0.0003
Plasmodium vivax importin-beta 2, putative 0.003 0.0017 0.0026
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0236 0.098
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0371 0.0644 0.1027
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0119 0.0182 0.0288
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0766 0.137 0.2187
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0095 0.0392
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.1607 0.2917 0.4657
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0095 0.015
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0008 0.0028
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0187 0.0187
Mycobacterium leprae conserved hypothetical protein 0.0075 0.01 1
Toxoplasma gondii ABC1 family protein 0.0075 0.01 0.0214
Schistosoma mansoni cpg binding protein 0.0087 0.0122 0.0194
Leishmania major importin beta-1 subunit, putative 0.0024 0.0007 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.01 0.016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0008 0.0008
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.1607 0.2917 0.2917
Echinococcus granulosus importin subunit beta 1 0.003 0.0017 0.0028
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0889 0.1596 0.2548
Mycobacterium ulcerans hypothetical protein 0.0166 0.0267 1
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0095 0.0095
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.0059
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0017 0.0067
Onchocerca volvulus 0.0842 0.151 0.5174
Loa Loa (eye worm) oxidoreductase 0.0021 0.0001 0.0001
Echinococcus granulosus protein farnesyltransferase subunit beta 0.1324 0.2396 0.3824
Onchocerca volvulus 0.0075 0.01 0.0344
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0119 0.0182 0.029
Loa Loa (eye worm) hypothetical protein 0.0072 0.0095 0.0095
Onchocerca volvulus 0.0766 0.137 0.4697
Echinococcus multilocularis glycine receptor subunit alpha 1 0.1607 0.2917 0.4657
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0095 0.0392
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.005 0.008
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.003 0.0018 0.0028
Schistosoma mansoni cpg binding protein 0.0096 0.0138 0.022
Loa Loa (eye worm) acetyltransferase 0.0153 0.0244 0.0244
Plasmodium vivax hypothetical protein, conserved 0.0075 0.01 0.0158
Schistosoma mansoni neurotransmitter gated ion channel 0.0766 0.137 0.2187
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0095 0.0392
Loa Loa (eye worm) polyprenyl synthetase 0.003 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.3428 0.6265 0.6265
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0143 0.0228
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0119 0.0182 0.0754
Echinococcus multilocularis dnaJ subfamily B 0.1235 0.2233 0.3564
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.01 0.0413
Echinococcus multilocularis protein patched 0.0042 0.004 0.0064
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0007 0.0009
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0889 0.1596 0.6661
Brugia malayi hypothetical protein 0.0309 0.0531 0.0531
Schistosoma mansoni transient receptor potential channel 0.0069 0.009 0.0144
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0026 0.0041
Brugia malayi PHD-finger family protein 0.0059 0.0071 0.0071
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0766 0.137 0.137
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0889 0.1596 0.1596
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.003 0.0018 0.0028
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.005 0.008
Leishmania major polyprenyl synthase, putative 0.003 0.0018 0.0068
Onchocerca volvulus 0.1607 0.2917 1
Brugia malayi hypothetical protein 0.0766 0.137 0.137
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.003 0.0018 0.0026
Toxoplasma gondii hypothetical protein 0.254 0.4631 1
Schistosoma mansoni glutathione synthetase 0.003 0.0018 0.0028
Plasmodium falciparum geranylgeranyltransferase, putative 0.0371 0.0644 0.1025
Treponema pallidum octaprenyl-diphosphate synthase 0.003 0.0018 0.5
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.0059
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.0236 0.098
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.1607 0.2917 0.4657
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0143 0.0226
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0002 0.0003
Mycobacterium tuberculosis Conserved protein 0.0075 0.01 0.1175
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0221 0.0352
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0889 0.1596 0.6661
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0842 0.151 0.151
Loa Loa (eye worm) hypothetical protein 0.0371 0.0644 0.0644
Schistosoma mansoni hypothetical protein 0.0103 0.0152 0.0242
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0056 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0889 0.1596 0.6661
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0371 0.0644 0.1387
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.1607 0.2917 0.2917
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0007 0.0009
Giardia lamblia Rab geranylgeranyltransferase 0.0889 0.1596 0.2505
Entamoeba histolytica hypothetical protein 0.0071 0.0093 0.0147
Schistosoma mansoni hypothetical protein 0.0031 0.0019 0.0031
Entamoeba histolytica hypothetical protein 0.0071 0.0093 0.0147
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.1607 0.2917 0.2917
Leishmania major geranylgeranyltransferase, putative 0.0371 0.0644 0.2682
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0315 0.0541 0.2252
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0001 0.0001
Echinococcus granulosus transient receptor potential ion channel A 0.0067 0.0086 0.0137
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.01 0.1175
Echinococcus multilocularis geminin 0.0353 0.0611 0.0975
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0889 0.1596 0.2548
Loa Loa (eye worm) hypothetical protein 0.1607 0.2917 0.2917
Schistosoma mansoni nAChR subunit 0.1607 0.2917 0.4657
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.013 0.02 0.032
Echinococcus multilocularis transient receptor potential gamma protein 0.0069 0.009 0.0144
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0044 0.0177
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0889 0.1596 0.2546
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0093 0.0149
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.003 0.0018 0.0018
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0889 0.1596 0.6661
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0371 0.0644 0.2682
Loa Loa (eye worm) hypothetical protein 0.0766 0.137 0.137
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.1607 0.2917 0.4657
Onchocerca volvulus 0.0021 0.0001 0.0005
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.0122 0.0122
Entamoeba histolytica hypothetical protein 0.0024 0.0007 0.0009
Echinococcus granulosus snurportin 1 0.0319 0.0549 0.0876

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 4.2 uM Effective concentration against US28-mediated inositol phosphate production in COS-7 cells ChEMBL. 16190772
EC50 (functional) = 4.2 uM Effective concentration against US28-mediated inositol phosphate production in COS-7 cells ChEMBL. 16190772
IC50 (binding) = 6.5 uM Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 ChEMBL. 16190772
IC50 (binding) = 6.5 uM Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5 ChEMBL. 16190772

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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