Detailed information for compound 416419

Basic information

Technical information
  • TDR Targets ID: 416419
  • Name: N-(2,4-diphenyl-1,3-thiazol-5-yl)-2-propylpen tanamide
  • MW: 378.53 | Formula: C23H26N2OS
  • H donors: 1 H acceptors: 2 LogP: 6.63 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(C(=O)Nc1sc(nc1c1ccccc1)c1ccccc1)CCC
  • InChi: 1S/C23H26N2OS/c1-3-11-18(12-4-2)21(26)25-23-20(17-13-7-5-8-14-17)24-22(27-23)19-15-9-6-10-16-19/h5-10,13-16,18H,3-4,11-12H2,1-2H3,(H,25,26)
  • InChiKey: PXEYEAFAGPIZFR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,4-diphenylthiazol-5-yl)-2-propyl-pentanamide
  • N-(2,4-diphenyl-5-thiazolyl)-2-propylpentanamide
  • N-(2,4-diphenyl-1,3-thiazol-5-yl)-2-propyl-pentanamide
  • N-(2,4-diphenylthiazol-5-yl)-2-propyl-valeramide
  • N-[2,4-di(phenyl)-1,3-thiazol-5-yl]-2-propylpentanamide
  • N-[2,4-di(phenyl)thiazol-5-yl]-2-propyl-pentanamide
  • N-[2,4-di(phenyl)-5-thiazolyl]-2-propylpentanamide
  • N-[2,4-di(phenyl)thiazol-5-yl]-2-propyl-valeramide
  • N-[2,4-di(phenyl)-1,3-thiazol-5-yl]-2-propyl-pentanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis PHD finger protein rhinoceros 0.0087 0.0556 0.057
Trypanosoma cruzi ISWI complex protein 0.0031 0.0114 0.0108
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0607 0.1667
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0014 0.0027
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0404 0.0415
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.002 0.0026 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.0776 0.2134
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0076 0.0466 0.049
Brugia malayi hypothetical protein 0.0043 0.0206 0.0202
Onchocerca volvulus 0.0115 0.0776 0.194
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0081 0.051 0.0523
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0372 0.2812 0.2802
Loa Loa (eye worm) latrophilin receptor protein 2 0.0133 0.0919 0.0906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0072 0.0777
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0374 0.0391
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0776 0.2134
Plasmodium vivax SET domain protein, putative 0.006 0.0343 0.3688
Onchocerca volvulus 0.0111 0.0747 0.1857
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0374 0.037
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0036 0.015 0.0161
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0047 0.0241 0.026
Schistosoma mansoni hypothetical protein 0.032 0.2401 0.2462
Schistosoma mansoni Smad4 0.0025 0.0063 0.0065
Schistosoma mansoni ran 0.0021 0.0032 0.0033
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0116 0.1917
Brugia malayi MH1 domain containing protein 0.0025 0.0063 0.0059
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0076 0.0466 0.049
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0306 0.2294 0.2352
Mycobacterium ulcerans polyketide synthase Pks13 0.0087 0.0552 0.0545
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0111 0.0747 0.0809
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0978 0.1003
Schistosoma mansoni hypothetical protein 0.0287 0.2141 0.2196
Mycobacterium ulcerans acyl-CoA synthetase 0.0111 0.0747 0.074
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.051 0.0523
Schistosoma mansoni hypothetical protein 0.0133 0.0919 0.0942
Plasmodium vivax JmjC domain containing protein 0.0028 0.0088 0.0951
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0047 0.0235 0.0228
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0111 0.0747 0.0815
Echinococcus granulosus serine:threonine protein kinase SMG1 0.002 0.0026 0.0027
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0127 0.0114
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0087 0.0556 0.057
Onchocerca volvulus 0.0115 0.0776 0.194
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0076 0.0466 1
Mycobacterium leprae Probable lipase LipE 0.0115 0.0776 0.0841
Brugia malayi Pre-SET motif family protein 0.0416 0.3167 0.3164
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0088 0.0091
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0026 0.0022
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0107 0.0714 0.0702
Mycobacterium ulcerans polyketide synthase 0.0058 0.0325 0.0318
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0034 0.0027
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0014 0.0007
Onchocerca volvulus 0.0038 0.0169 0.0222
Leishmania major 4-coumarate:coa ligase-like protein 0.0111 0.0747 0.0815
Schistosoma mansoni DNA polymerase eta 0.0019 0.0014 0.0014
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0372 0.2812 0.2809
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0056 0.0311 0.0337
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0206 0.0211
Entamoeba histolytica hypothetical protein 0.032 0.2401 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.002 0.0026 0.0013
Mycobacterium ulcerans hypothetical protein 0.0115 0.0776 0.077
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0142 0.0146
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0165 0.1176 0.1286
Leishmania major hypothetical protein, conserved 0.0115 0.0776 0.0847
Entamoeba histolytica acyl-CoA synthetase, putative 0.0111 0.0747 0.307
Schistosoma mansoni hypothetical protein 0.0304 0.2277 0.2335
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0014 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0034 0.0033
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0036 0.015 0.0161
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0014 0.0011
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.015 0.1616
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0032 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0794 0.3268
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0049 0.0124
Toxoplasma gondii ABC1 family protein 0.0115 0.0776 0.8338
Toxoplasma gondii type I fatty acid synthase, putative 0.0041 0.0192 0.2067
Schistosoma mansoni steroid hormone receptor ad4bp 0.0081 0.051 0.0523
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0063 0.0049
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.0466 0.1277
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0095 0.062 0.0635
Leishmania major importin beta-1 subunit, putative 0.0023 0.0049 0.0049
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0115 0.0776 0.0847
Brugia malayi jmjC domain containing protein 0.0285 0.2127 0.2124
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0306 0.2294 0.2352
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0081 0.051 0.0506
Loa Loa (eye worm) fatty acid synthase 0.0057 0.0319 0.0305
Mycobacterium ulcerans Type I modular polyketide synthase 0.0058 0.0325 0.0318
Echinococcus granulosus FTZ F1 alpha 0.0081 0.051 0.0523
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0063 0.0065
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0082 0.0743
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0116 0.0311
Brugia malayi hypothetical protein 0.0255 0.1885 0.1882
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0206 0.0202
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.0192
Brugia malayi latrophilin 2 splice variant baaae 0.0287 0.2141 0.2138
Loa Loa (eye worm) hypothetical protein 0.0038 0.0169 0.0156
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0028 0.0091 0.0845
Onchocerca volvulus 0.0081 0.051 0.1185
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0169 0.0174
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0091 0.0981
Schistosoma mansoni hypothetical protein 0.0031 0.0114 0.0116
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0466 1
Brugia malayi jmjC domain containing protein 0.0028 0.0088 0.0085
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0082 0.0881
Loa Loa (eye worm) hypothetical protein 0.0038 0.0169 0.0156
Mycobacterium ulcerans esterase/lipase LipP 0.0115 0.0776 0.077
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0142 0.0146
Echinococcus granulosus jumonji domain containing protein 0.0121 0.0827 0.0848
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0117 0.0793 0.0787
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0111 0.0747 0.0815
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0081 0.051 0.0496
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0241 0.0247
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0111 0.0747 0.307
Echinococcus granulosus pyruvate kinase 0.0033 0.0127 0.0131
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0068 0.0404 0.0415
Brugia malayi ecdysteroid receptor 0.0081 0.051 0.0506
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0794 0.2184
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0116 0.1251
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.003 0.0105 0.1129
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0076 0.0466 0.7676
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0374 0.0361
Loa Loa (eye worm) Smad1 0.0025 0.0063 0.0049
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0734 0.5682 0.623
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0061 0.0353 0.0347
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0127 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0081 0.051 0.0506
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0306 0.2294 0.2352
Onchocerca volvulus 0.0125 0.0854 0.2162
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0063 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.0776 0.0826
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0023 0.0051 0.0052
Loa Loa (eye worm) acyl carrier protein 0.0027 0.0077 0.0063
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0061 0.0353 0.0347
Chlamydia trachomatis pyruvate kinase 0.0033 0.0127 0.0317
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0088 0.0091
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0794 0.0781
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.1885 0.1933
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.1049 0.1045
Leishmania major 4-coumarate:coa ligase-like protein 0.0111 0.0747 0.0815
Loa Loa (eye worm) beta-lactamase 0.0115 0.0776 0.0763
Schistosoma mansoni voltage-gated cation channel 0.0306 0.2294 0.2352
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0081 0.051 0.0506
Entamoeba histolytica hypothetical protein 0.032 0.2401 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0404 0.0391
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.0776 0.0795
Trypanosoma cruzi PAB1-binding protein , putative 0.0134 0.0931 0.0994
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0372 0.2812 0.2883
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0111 0.0747 0.0815
Echinococcus multilocularis dna polymerase eta 0.0019 0.0014 0.0014
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.1182 0.9241 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0081 0.051 0.0523
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0061 0.0353 0.0383
Loa Loa (eye worm) hypothetical protein 0.0081 0.051 0.0496
Onchocerca volvulus 0.0165 0.1176 0.3072
Leishmania major fatty acid transporter protein-like protein 0.1167 0.9119 1
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0169 0.0174
Mycobacterium tuberculosis Probable lipase LipD 0.0115 0.0776 0.0847
Loa Loa (eye worm) hypothetical protein 0.0255 0.1885 0.1874
Schistosoma mansoni hypothetical protein 0.006 0.0343 0.0352
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0034 0.0132 0.0136
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.032 0.2401 0.2462
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0116 0.1251
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0076 0.0466 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.015 0.0161
Brugia malayi Steroid receptor seven-up type 2 0.0081 0.051 0.0506
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0117 0.0793 0.0787
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0061 0.0353 0.0383
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0088 0.0081
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0174 0.0672
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0127 0.0114
Echinococcus granulosus snurportin 1 0.0304 0.2277 0.2335
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0028 0.0091 0.0981
Echinococcus granulosus voltage dependent calcium channel 0.0306 0.2294 0.2352
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0111 0.0747 0.0809
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0607 0.0594
Loa Loa (eye worm) hypothetical protein 0.0038 0.0169 0.0156
Echinococcus multilocularis pyruvate kinase 0.0033 0.0127 0.0131
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0111 0.0747 0.074
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0169 0.0174
Brugia malayi AMP-binding enzyme family protein 0.0111 0.0747 0.0743
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0285 0.2127 0.2181
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.2277 0.2266
Schistosoma mansoni pyruvate kinase 0.0033 0.0127 0.0131
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0036 0.015 0.0154
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0794 0.8509
Echinococcus granulosus dna polymerase eta 0.0019 0.0014 0.0014
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0169 0.0156
Echinococcus multilocularis serine protein kinase ATM 0.0049 0.0257 0.0263
Brugia malayi PHD-finger family protein 0.0056 0.031 0.0306
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0117 0.0793 0.0787
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Brugia malayi ecdysone receptor 0.0038 0.0169 0.0166
Loa Loa (eye worm) hypothetical protein 0.0107 0.0712 0.0699
Trichomonas vaginalis set domain proteins, putative 0.0474 0.3622 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0018
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0042 0.0028
Mycobacterium tuberculosis Conserved protein 0.0115 0.0776 0.0847
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0111 0.0747 0.0766
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.0776 0.2134
Onchocerca volvulus Bile acid receptor homolog 0.0081 0.051 0.1185
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0127 0.124
Giardia lamblia Kinase, PLK 0.0094 0.0607 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0047 0.0235 0.0247
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.032 0.2401 0.2462
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0014 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0063 0.0049
Loa Loa (eye worm) hypothetical protein 0.0023 0.0045 0.0031
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0076 0.0466 0.4932
Brugia malayi hypothetical protein 0.0134 0.0931 0.0927
Treponema pallidum exodeoxyribonuclease (exoA) 0.0076 0.0466 0.5456
Brugia malayi Probable ClpP-like protease 0.0076 0.0466 0.0462
Brugia malayi nuclear receptor NHR-88 0.0038 0.0169 0.0166
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0244 0.025
Schistosoma mansoni kinase 0.0048 0.0242 0.0249
Mycobacterium tuberculosis Probable hydrolase 0.0115 0.0776 0.0847
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0032 0.0033
Loa Loa (eye worm) acetyltransferase 0.0149 0.1049 0.1037
Loa Loa (eye worm) hypothetical protein 0.0092 0.0598 0.0585
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0306 0.2294 0.2352
Entamoeba histolytica Ran family GTPase 0.0021 0.0032 0.0076
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0129 0.0125
Entamoeba histolytica acyl-CoA synthetase, putative 0.0117 0.0793 0.3264
Loa Loa (eye worm) hypothetical protein 0.0038 0.0169 0.0156
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.006 0.0343 0.0352
Mycobacterium ulcerans lipase LipD 0.0115 0.0776 0.077
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0188
Entamoeba histolytica protein kinase rad3, putative 0.002 0.0026 0.0052
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0343 0.3688
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0036 0.015 0.0154
Loa Loa (eye worm) hypothetical protein 0.0111 0.0747 0.0734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Loa Loa (eye worm) bromodomain containing protein 0.004 0.018 0.0166
Loa Loa (eye worm) oxidoreductase 0.0111 0.0747 0.0734
Brugia malayi Muscleblind-like protein 0.0457 0.3491 0.3488
Onchocerca volvulus 0.006 0.0343 0.0714
Brugia malayi jmjC domain containing protein 0.0028 0.0088 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0257 0.0699
Schistosoma mansoni hypothetical protein 0.0028 0.0091 0.0094
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0306 0.2294 0.2352
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0321 0.0329
Echinococcus multilocularis long chain fatty acid transport protein 4 0.1182 0.9241 0.9475
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0374 0.0391
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0058 0.0325 0.0346
Brugia malayi Nuclear hormone receptor-like 1 0.0081 0.051 0.0506
Mycobacterium ulcerans acyl-CoA synthetase 0.0111 0.0747 0.074
Loa Loa (eye worm) voltage-dependent calcium channel 0.0107 0.0712 0.0699
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.0794 0.0861
Loa Loa (eye worm) hypothetical protein 0.0145 0.1012 0.0999
Mycobacterium ulcerans hypothetical protein 0.0111 0.0747 0.074
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0091 0.0077
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.0745 0.0764
Brugia malayi hypothetical protein 0.009 0.0582 0.0579
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0081 0.051 0.0523
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0374 0.0384
Brugia malayi Bromodomain containing protein 0.0082 0.0514 0.0511
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0448 0.0459
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0169 0.0174
Entamoeba histolytica acyl-CoA synthetase, putative 0.0021 0.0034 0.0086
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0466 0.5002
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0036 0.015 0.149
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0174 0.287
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0036 0.015 0.0572
Mycobacterium ulcerans fatty acid synthase Fas 0.0018 0.001 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0088 0.0075
Echinococcus multilocularis GPCR, family 2 0.0133 0.0919 0.0942
Mycobacterium ulcerans beta-lactamase 0.0115 0.0776 0.077
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0169 0.0174
Loa Loa (eye worm) hypothetical protein 0.0115 0.0776 0.0763
Brugia malayi hypothetical protein 0.032 0.2401 0.2398
Brugia malayi jmjC domain containing protein 0.0111 0.0745 0.0742
Echinococcus multilocularis Smad4 0.0025 0.0063 0.0065
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0088 0.0951
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0121 0.0108
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0306 0.2294 0.2352
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0466 0.0477
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0081 0.051 0.0523
Brugia malayi jmjC domain containing protein 0.0028 0.0088 0.0085
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.0169 0.0174
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0014 0.001
Brugia malayi nuclear receptor NHR-88 0.0081 0.051 0.0506
Brugia malayi AMP-binding enzyme family protein 0.0165 0.1176 0.1172
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0036 0.015 0.0161
Brugia malayi Cytochrome P450 family protein 0.0032 0.0121 0.0117
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.3077 0.3155
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0091 0.0847
Loa Loa (eye worm) hypothetical protein 0.0306 0.2294 0.2284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Brugia malayi MH1 domain containing protein 0.0025 0.0063 0.0059
Schistosoma mansoni hypothetical protein 0.0405 0.3077 0.3155
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0081 0.051 0.0523
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0042 0.0028
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0081 0.051 0.0523
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0082 0.0881
Echinococcus multilocularis smad 0.0025 0.0063 0.0065
Mycobacterium ulcerans acyl-CoA synthetase 0.0111 0.0747 0.074
Brugia malayi nuclear receptor NHR-67 0.0038 0.0169 0.0166
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0466 0.0477
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0115 0.0776 0.0847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Schistosoma mansoni smad 0.0025 0.0063 0.0065
Brugia malayi Calcitonin receptor-like protein seb-1 0.042 0.3195 0.3192
Brugia malayi Latrophilin receptor protein 2 0.0133 0.0919 0.0915
Loa Loa (eye worm) hypothetical protein 0.0081 0.051 0.0496
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.015 0.0148
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0072 0.0069
Brugia malayi beta-lactamase 0.0115 0.0776 0.0772
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0088 0.0091
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0088 0.0091
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0127 0.0114
Echinococcus multilocularis jumonji domain containing protein 0.0121 0.0827 0.0848
Loa Loa (eye worm) hypothetical protein 0.0028 0.0088 0.0075
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0794 0.0814
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0014 0.0011
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0088 0.0091
Leishmania major cytochrome p450-like protein 0.0022 0.0042 0.0042
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0014 0.0014
Onchocerca volvulus 0.0212 0.1546 0.412
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0169 0.0166
Echinococcus granulosus peregrin 0.0095 0.0623 0.0638
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0088 0.0815
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0374 0.0384
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0169 0.0166
Brugia malayi Bromodomain containing protein 0.0095 0.0623 0.0619
Mycobacterium leprae conserved hypothetical protein 0.0115 0.0776 0.0841
Schistosoma mansoni ap endonuclease 0.0076 0.0466 0.0478
Echinococcus multilocularis voltage dependent calcium channel 0.0306 0.2294 0.2352
Schistosoma mansoni pyruvate kinase 0.0033 0.0127 0.0131
Brugia malayi nuclear hormone receptor 0.0081 0.051 0.0506
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.0794 0.0867
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0058 0.0325 0.0352
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0776 0.8338
Mycobacterium ulcerans acyl-CoA synthetase 0.0111 0.0747 0.074
Echinococcus granulosus serine protein kinase ATM 0.0049 0.0257 0.0263
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0372 0.2812 0.2883
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0096 0.0624 0.0681
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0127 0.0129
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.0466 0.5008
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0045 0.0335
Loa Loa (eye worm) hypothetical protein 0.0038 0.0169 0.0156
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0127 0.124
Loa Loa (eye worm) hypothetical protein 0.0081 0.051 0.0496
Schistosoma mansoni jumonji domain containing protein 0.0227 0.1663 0.1705
Brugia malayi MH2 domain containing protein 0.0025 0.0063 0.0059
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0127 0.137
Plasmodium vivax acetyl-CoA synthetase, putative 0.0111 0.0747 0.8023
Trichomonas vaginalis ran, putative 0.0021 0.0032 0.0077
Echinococcus multilocularis muscleblind protein 0.0457 0.3491 0.3579
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0115 0.0776 0.0847
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0466 0.0459
Echinococcus granulosus transcription factor Dp 1 0.0037 0.016 0.0164
Echinococcus multilocularis pyruvate kinase 0.0033 0.0127 0.0131
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0082 0.135
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0855 0.6643 0.6811
Mycobacterium tuberculosis Conserved protein 0.0115 0.0776 0.0847
Schistosoma mansoni hypothetical protein 0.0133 0.0919 0.0942
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0372 0.2812 0.2883
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0169 0.0166
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0111 0.0747 0.074
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.0776 0.0795
Loa Loa (eye worm) hypothetical protein 0.0133 0.0919 0.0906
Echinococcus granulosus muscleblind protein 0.0457 0.3491 0.3579
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.0466 0.5008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.062 0.0635
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0018 0.0007 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0081 0.051 0.0496
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0117 0.0793 0.0789
Mycobacterium ulcerans acyl-CoA synthetase 0.0111 0.0747 0.074
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0036 0.015 0.149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Brugia malayi Importin beta-1 subunit 0.0028 0.0091 0.0088
Loa Loa (eye worm) hypothetical protein 0.0095 0.062 0.0607
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0091 0.0983
Schistosoma mansoni hypothetical protein 0.1247 0.9753 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0056 0.0311 0.0337
Mycobacterium ulcerans thioesterase 0.0048 0.0248 0.0242
Mycobacterium leprae Polyketide synthase Pks13 0.0087 0.0552 0.0595
Schistosoma mansoni thyroid hormone receptor 0.0081 0.051 0.0523
Schistosoma mansoni coup transcription factor 0.0081 0.051 0.0523
Brugia malayi AMP-binding enzyme family protein 0.0111 0.0747 0.0743
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0117 0.0793 0.0787
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0169 0.0174
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0111 0.0747 0.7993
Loa Loa (eye worm) hypothetical protein 0.0087 0.0554 0.0541
Echinococcus granulosus importin subunit beta 1 0.0028 0.0091 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0081 0.051 0.0496
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0081 0.051 0.0496
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.051 0.0506
Loa Loa (eye worm) pigment dispersing factor receptor c 0.042 0.3195 0.3185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0233 0.0632
Entamoeba histolytica hypothetical protein 0.032 0.2401 1
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.1885 0.1933
Echinococcus granulosus phd:f box containing protein 0.0028 0.0088 0.0091
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.015 0.0137
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0259 0.028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.051 0.0523
Mycobacterium tuberculosis Probable lipase LipE 0.0115 0.0776 0.0847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0045 0.0112
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0049 0.0038
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0116 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0081 0.051 0.0506
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0206 0.0202
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0042 0.0035
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0169 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0794 0.3268
Brugia malayi PHD-finger family protein 0.0034 0.0135 0.0131
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.002
Schistosoma mansoni zinc finger protein 0.0038 0.0169 0.0174
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.002 0.0023 0.0021
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0115 0.0776 0.0772
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0448 0.0459
Schistosoma mansoni methyltransferase-related 0.0017 0.0004 0.0004
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0111 0.0747 0.0815
Loa Loa (eye worm) hypothetical protein 0.0034 0.0135 0.0121
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0116 0.043
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0133 0.0919 0.0942
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.1167 0.9119 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0087 0.0552 0.0601
Schistosoma mansoni zinc finger protein 0.0031 0.0114 0.0116
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0127 0.0121
Schistosoma mansoni cpg binding protein 0.0034 0.0135 0.0138
Schistosoma mansoni hypothetical protein 0.0133 0.0919 0.0942
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0285 0.2127 0.2181
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0028
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.002 0.0026 0.0027
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0014 0.0011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0081 0.051 0.0523
Loa Loa (eye worm) hypothetical protein 0.0068 0.0404 0.0391
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0081 0.051 0.0523
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.051 0.0523
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0049 0.0257 0.0263
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.0776 0.0796
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0142 0.0146
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.0078
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0107 0.0712 0.761
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0259 0.0273
Mycobacterium ulcerans acyl-CoA synthetase 0.0111 0.0747 0.074
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0076 0.0466 0.0478
Mycobacterium tuberculosis Conserved protein 0.0115 0.0776 0.0847
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0306 0.2294 0.2352
Loa Loa (eye worm) DR-78 0.0038 0.0169 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.051 0.0506
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0081 0.051 0.0523
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0115 0.0776 0.0847
Brugia malayi steroid hormone receptor 0.0081 0.051 0.0506
Echinococcus granulosus voltage dependent calcium channel 0.0107 0.0712 0.073
Trypanosoma brucei PAB1-binding protein , putative 0.0134 0.0931 1
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0116 0.1251
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0607 0.1667
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0038 0.0169 0.0163
Brugia malayi MH2 domain containing protein 0.0366 0.2765 0.2762
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0117 0.0793 0.0866
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0374 0.0406
Brugia malayi jmjC domain containing protein 0.0028 0.0088 0.0085
Brugia malayi Pre-SET motif family protein 0.006 0.0343 0.034
Schistosoma mansoni flap endonuclease-1 0.0025 0.0061 0.0063
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0115 0.0776 0.077
Loa Loa (eye worm) hypothetical protein 0.0038 0.0169 0.0156
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0042 0.0028
Schistosoma mansoni smad1 5 8 and 0.0025 0.0063 0.0065
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0081 0.051 0.0523
Brugia malayi AF-10 protein 0.0028 0.0091 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0026 0.0062
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.006 0.0343 0.0352
Echinococcus granulosus histone lysine methyltransferase setb 0.0095 0.062 0.0635
Leishmania major acetyl-CoA synthetase, putative 0.0111 0.0747 0.0815
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0343 0.0352
Echinococcus multilocularis cpg binding protein 0.0034 0.0135 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.051 0.0506
Loa Loa (eye worm) hypothetical protein 0.0134 0.0931 0.0918
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0169 0.0174
Echinococcus granulosus geminin 0.1247 0.9753 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0034 0.0132 0.0136
Toxoplasma gondii PHD-finger domain-containing protein 0.0087 0.0556 0.5976
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0127 0.0136
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0343 0.0352
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0607 0.1667
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0032 0.0342
Schistosoma mansoni nuclear receptor 0.0038 0.0169 0.0174
Brugia malayi MH2 domain containing protein 0.0025 0.0063 0.0059
Brugia malayi Bromodomain containing protein 0.0158 0.1122 0.1118
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.0794 0.0814
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0026 0.0062
Loa Loa (eye worm) hypothetical protein 0.0113 0.0759 0.0747
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.0776 0.0769
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.0169 0.0156
Mycobacterium ulcerans acyl-CoA synthetase 0.0111 0.0747 0.074
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0241 0.0654
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0026 0.0062
Leishmania major 4-coumarate:coa ligase-like protein 0.0111 0.0747 0.0815
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0081 0.051 0.0523
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0036 0.015 0.149
Brugia malayi beta-lactamase family protein 0.0115 0.0776 0.0772
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0081 0.051 0.0496
Brugia malayi hypothetical protein 0.0038 0.0169 0.0166
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0018 0.001 0.0006
Leishmania major DNA polymerase eta, putative 0.0019 0.0014 0.0011
Schistosoma mansoni hypothetical protein 0.0133 0.0919 0.0942
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.015 0.149
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0794 0.2184
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0076 0.0466 0.0478
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.1167 0.9119 1
Echinococcus granulosus dnaJ subfamily B 0.0405 0.3077 0.3155
Plasmodium falciparum ataxin-2 like protein, putative 0.0134 0.0931 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0487 0.0474
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0061 0.0353 0.0377
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0045 0.0112
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0088 0.0091
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.0192
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0466 0.0477
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0063 0.0065
Loa Loa (eye worm) hypothetical protein 0.0081 0.051 0.0496
Trypanosoma brucei ISWI complex protein 0.0031 0.0114 0.1087
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0133 0.0919 0.0915
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0116 0.1251
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0244 0.025
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0127 0.0123
Toxoplasma gondii FATC domain-containing protein 0.0049 0.0257 0.2759
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0111 0.0747 0.074
Onchocerca volvulus 0.0052 0.0278 0.0528
Schistosoma mansoni hypothetical protein 0.0087 0.0556 0.057
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.0776 0.8313
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0026 0.0062
Schistosoma mansoni fkbp-rapamycin associated protein 0.002 0.0026 0.0027
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0111 0.0747 0.0766
Onchocerca volvulus Alhambra homolog 0.0087 0.0556 0.1317
Mycobacterium ulcerans acyl-CoA synthetase 0.0111 0.0747 0.074
Loa Loa (eye worm) calcium channel 0.0306 0.2294 0.2284
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0061 0.0353 0.0377
Schistosoma mansoni importin beta-1 0.0028 0.0091 0.0094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0372 0.2812 0.2883
Schistosoma mansoni acetyl-CoA synthetase 0.0111 0.0747 0.0766
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0776 0.2134
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0116 0.1251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0306 0.2294 0.2352
Toxoplasma gondii LsmAD domain-containing protein 0.0134 0.0931 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0036 0.015 0.0154
Loa Loa (eye worm) transcription factor SMAD2 0.0366 0.2765 0.2755
Echinococcus multilocularis snurportin 1 0.0304 0.2277 0.2335
Loa Loa (eye worm) hypothetical protein 0.0149 0.105 0.1037
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0036 0.015 0.0154
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0038 0.0169 0.0175
Mycobacterium ulcerans acyl-CoA synthetase 0.0117 0.0793 0.0787
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0241 0.2586
Echinococcus multilocularis muscleblind protein 1 0.0457 0.3491 0.3579
Brugia malayi nuclear receptor RXR 0.0038 0.0169 0.0166
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.015 0.0148
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0014 0.0014
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0043 0.0206 0.0211
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.015 0.0137
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0028 0.0091 0.0845
Brugia malayi nuclear hormone receptor 0.0038 0.0169 0.0166
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0127 0.0874 0.0896
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0361 0.037
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.042 0.3195 0.3192
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0042 0.003
Brugia malayi CXXC zinc finger family protein 0.0028 0.0091 0.0087
Echinococcus granulosus carboxylesterase 5A 0.0068 0.0404 0.0415
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0607 0.0643
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0116 0.0311
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0042 0.0305
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0088 0.0091
Brugia malayi Cytochrome P450 family protein 0.0022 0.0042 0.0038
Onchocerca volvulus 0.0115 0.0776 0.194
Loa Loa (eye worm) hypothetical protein 0.0023 0.0048 0.0034
Brugia malayi Smad1 0.0025 0.0063 0.0059
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0115 0.0776 0.0772
Brugia malayi nuclear receptor RXR 0.0043 0.0206 0.0202
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.1278 1 1
Mycobacterium leprae Probable polyketide synthase Pks1 0.0061 0.0353 0.0377
Loa Loa (eye worm) AMP-binding enzyme family protein 0.1278 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0607 0.0623
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0111 0.0747 0.074
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0043 0.0206 0.0211
Onchocerca volvulus 0.0111 0.0747 0.1857
Loa Loa (eye worm) hypothetical protein 0.0038 0.0169 0.0156
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0257 0.0253
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.0776 0.0769
Schistosoma mansoni smad1 5 8 and 0.0025 0.0063 0.0065
Brugia malayi tailless protein 0.0038 0.0169 0.0166
Loa Loa (eye worm) hypothetical protein 0.0081 0.051 0.0496
Leishmania major phosphatidylinositol 3-kinase, putative 0.0036 0.015 0.0161
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0082 0.0074
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0169 0.0174
Loa Loa (eye worm) acetylcholinesterase 1 0.0068 0.0404 0.0391
Loa Loa (eye worm) hypothetical protein 0.0081 0.051 0.0496
Loa Loa (eye worm) hypothetical protein 0.0111 0.0747 0.0734
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0082 0.0086
Brugia malayi 6-phosphofructokinase 0.0117 0.0794 0.079
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0607 0.0623
Loa Loa (eye worm) hypothetical protein 0.0028 0.0088 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Brugia malayi phosphofructokinase 0.0117 0.0794 0.079
Mycobacterium ulcerans acetyl-CoA synthetase 0.0111 0.0747 0.074
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0259 0.0265
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.0794 0.0788
Echinococcus granulosus acetylcholinesterase 0.0068 0.0404 0.0415
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0197
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0036 0.015 0.0148
Brugia malayi Carboxylesterase family protein 0.0068 0.0404 0.0401
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0036 0.0151 0.0149
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0133 0.0919 0.0942
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0111 0.0747 0.0743
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0111 0.0747 0.0815
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0111 0.0747 0.0809
Schistosoma mansoni eyes absent homolog 0.009 0.0582 0.0597
Echinococcus granulosus AMP dependent ligase 0.0021 0.0034 0.0035
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0244 0.025
Plasmodium vivax importin-beta 2, putative 0.0028 0.0091 0.0983
Echinococcus granulosus pyruvate kinase 0.0033 0.0127 0.0131
Toxoplasma gondii hypothetical protein 0.0026 0.0072 0.0777
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0076 0.0466 0.0453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0372 0.2812 0.2883
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0343 0.0352
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0111 0.0747 0.074
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0794 0.0846
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0049 0.0124
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0088 0.0075
Schistosoma mansoni survival motor neuron protein 0.0052 0.0278 0.0285
Loa Loa (eye worm) hypothetical protein 0.0457 0.3491 0.3482
Entamoeba histolytica hypothetical protein 0.0023 0.0049 0.0146
Schistosoma mansoni ap endonuclease 0.0076 0.0466 0.0478
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0048 0.0144
Echinococcus granulosus lysine specific demethylase 5A 0.0111 0.0745 0.0764
Loa Loa (eye worm) hypothetical protein 0.0115 0.0776 0.0763
Loa Loa (eye worm) hypothetical protein 0.0111 0.0747 0.0734
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0127 0.0103
Plasmodium vivax ataxin-2 like protein, putative 0.0134 0.0931 1
Echinococcus granulosus smad 0.0025 0.0063 0.0065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0111 0.0747 0.0815
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0081 0.051 0.0523
Schistosoma mansoni RAR-like nuclear receptor 0.0081 0.051 0.0523
Echinococcus multilocularis beta LACTamase domain containing family member 0.0115 0.0776 0.0796
Mycobacterium ulcerans polyketide synthase 0.0061 0.0353 0.0347
Loa Loa (eye worm) hypothetical protein 0.0111 0.0747 0.0734
Plasmodium falciparum importin beta, putative 0.0028 0.0091 0.0983
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.0745 0.0764
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0021 0.0034 0.0028
Loa Loa (eye worm) hypothetical protein 0.0115 0.0776 0.0763
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0081 0.051 0.0523
Plasmodium falciparum ataxin-2 like protein, putative 0.0134 0.0931 1
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0088 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0081 0.051 0.0506
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0036 0.015 0.0154
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0111 0.0747 0.0794
Plasmodium falciparum flap endonuclease 1 0.0027 0.0082 0.0881
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0021 0.0034 0.0028
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0036 0.015 0.0154
Echinococcus multilocularis FTZ F1 alpha 0.0081 0.051 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0466 0.5448
Entamoeba histolytica hypothetical protein 0.032 0.2401 1
Schistosoma mansoni retinoic acid receptor RXR 0.0081 0.051 0.0523
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0111 0.0747 0.0809
Mycobacterium ulcerans acyl-CoA synthetase 0.0111 0.0747 0.074
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0374 0.0384
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0306 0.2294 0.2352
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0116 0.0311
Echinococcus granulosus dna polymerase kappa 0.0019 0.0014 0.0014
Onchocerca volvulus 0.0038 0.0169 0.0222
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0042 0.0195 0.021
Toxoplasma gondii PHD-finger domain-containing protein 0.0087 0.0556 0.5976
Schistosoma mansoni hypothetical protein 0.1247 0.9753 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0111 0.0747 0.074
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0081 0.051 0.0506
Loa Loa (eye worm) hypothetical protein 0.0287 0.2141 0.2131
Loa Loa (eye worm) hypothetical protein 0.0094 0.061 0.0597
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0174 0.1872
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0038 0.0163 0.1756
Brugia malayi 6-phosphofructokinase 0.0117 0.0794 0.079
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0169 0.0174
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0416 0.3167 0.3157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0049 0.0257 0.265
Echinococcus multilocularis ecdysone induced protein 78C 0.0081 0.051 0.0523
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0165 0.0169
Mycobacterium tuberculosis Probable thioesterase TesA 0.0048 0.0248 0.0268
Trypanosoma brucei polo-like protein kinase 0.0094 0.0607 0.6471
Loa Loa (eye worm) hypothetical protein 0.0081 0.051 0.0496
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.0794 0.0814
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0116 0.0311
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0111 0.0747 0.8023
Echinococcus granulosus long chain fatty acid transport protein 4 0.1182 0.9241 0.9475
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0072 0.0777
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0169 0.0222
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0133 0.0919 0.0942
Brugia malayi AMP-binding enzyme family protein 0.0111 0.0747 0.0743
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0088 0.0091
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0607 0.1667
Loa Loa (eye worm) hypothetical protein 0.0038 0.0169 0.0156
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.0794 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.051 0.0506
Echinococcus multilocularis voltage dependent calcium channel 0.0306 0.2294 0.2352
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0169 0.0174
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0031 0.0109 0.0103
Loa Loa (eye worm) hypothetical protein 0.0038 0.0169 0.0156
Loa Loa (eye worm) hypothetical protein 0.0094 0.061 0.0597
Toxoplasma gondii propionate-CoA ligase 0.0111 0.0747 0.8023
Loa Loa (eye worm) hypothetical protein 0.0115 0.0776 0.0763
Trichomonas vaginalis antibiotic synthetase, putative 0.0111 0.0747 0.2053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0607 0.2485
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.0776 0.0796
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0115 0.0776 0.0763
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0169 0.0166
Echinococcus granulosus Smad4 0.0025 0.0063 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0043 0.0206 0.0192
Schistosoma mansoni FFA transport protein 0.1182 0.9241 0.9475
Plasmodium falciparum pyruvate kinase 0.0033 0.0127 0.137
Onchocerca volvulus Protein ultraspiracle homolog 0.0081 0.051 0.1185
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0058 0.0325 0.0318
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.02 0.0186
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0049 0.0124
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0794 0.0814
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0107 0.0712 0.0756
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0607 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0026 0.0062
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0049 0.0257 0.0263
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0117 0.0793 0.0866
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0032 0.0342
Brugia malayi F/Y-rich N-terminus family protein 0.0043 0.0209 0.0205
Leishmania major DNA polymerase kappa, putative 0.0019 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0115 0.0776 0.0763
Echinococcus granulosus beta LACTamase domain containing family member 0.0115 0.0776 0.0796
Loa Loa (eye worm) hypothetical protein 0.0038 0.0169 0.0156
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.0192
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0116 0.0311
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0042 0.0202 0.0204
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0169 0.0174
Echinococcus multilocularis peregrin 0.0095 0.0623 0.0638
Onchocerca volvulus 0.0474 0.3622 1
Schistosoma mansoni hypothetical protein 0.0052 0.0278 0.0285
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0115 0.0776 0.0795
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.015 0.0147
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0111 0.0747 0.8023
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.015 0.0147
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0142 0.0146
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0259 0.028
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0088 0.0091
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0082 0.0286
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.016 0.0164
Plasmodium falciparum phd finger protein, putative 0.0087 0.0556 0.5976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0033 0.0127 0.0135
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0607 0.1667
Loa Loa (eye worm) hypothetical protein 0.0111 0.0747 0.0734
Schistosoma mansoni zinc finger protein 0.0045 0.0224 0.0229
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0042 0.003
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0076 0.0466 0.0507
Mycobacterium ulcerans Type I modular polyketide synthase 0.0058 0.0325 0.0318
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0127 0.137
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0607 0.1667
Echinococcus multilocularis zinc finger protein 0.0045 0.0224 0.0229
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0111 0.0747 0.7993
Giardia lamblia PHD finger protein 15 0.0087 0.0556 0.9161
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0241 0.2586
Entamoeba histolytica acyl-coA synthetase, putative 0.0111 0.0747 0.307
Leishmania major GTP-binding protein, putative 0.0021 0.0032 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0233 0.0632
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0081 0.051 0.0523
Plasmodium vivax hypothetical protein, conserved 0.0087 0.0556 0.5976
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0045 0.022 0.2365
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.0192
Onchocerca volvulus Fatty acid synthase homolog 0.0104 0.0693 0.1705
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0404 0.0415
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0466 0.05
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0082 0.0216
Leishmania major phosphatidylinositol kinase related protein, putative 0.0036 0.0151 0.0161
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0127 0.0123
Loa Loa (eye worm) carboxylesterase 0.0068 0.0404 0.0391
Schistosoma mansoni thyroid hormone receptor 0.0081 0.051 0.0523
Brugia malayi Flap endonuclease-1 0.0027 0.0082 0.0078
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0466 0.5002
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0076 0.0466 0.1894
Toxoplasma gondii transporter, cation channel family protein 0.0107 0.0712 0.7646
Loa Loa (eye worm) hypothetical protein 0.009 0.0582 0.0569
Schistosoma mansoni nuclear receptor 0.0038 0.0169 0.0174
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0127 0.0124
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.0466 0.1277
Mycobacterium ulcerans thioesterase TesA 0.0048 0.0248 0.0242
Loa Loa (eye worm) hypothetical protein 0.0087 0.0556 0.0543
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.1049 0.1075
Giardia lamblia Methyltransferase like 2 0.0017 0.0004 0.0064
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0794 0.2184
Echinococcus granulosus GPCR family 2 0.0133 0.0919 0.0942
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0038 0.0169 0.0174
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0111 0.0747 0.0794
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0165 0.1176 0.1163
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0607 0.0603
Brugia malayi Carboxylesterase family protein 0.0068 0.0404 0.0401
Mycobacterium ulcerans Type I modular polyketide synthase 0.0058 0.0325 0.0318
Schistosoma mansoni amine GPCR 0.0331 0.2488 0.2551
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0374 0.393
Brugia malayi beta-lactamase family protein 0.0115 0.0776 0.0772
Giardia lamblia Pyruvate kinase 0.0033 0.0127 0.2099
Toxoplasma gondii exonuclease III APE 0.0076 0.0466 0.5008
Leishmania major pyruvate kinase 0.0033 0.0127 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Brugia malayi hypothetical protein 0.0043 0.0206 0.0202
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.0192
Echinococcus granulosus PHD finger protein rhinoceros 0.0087 0.0556 0.057
Giardia lamblia DINP protein human, muc B family 0.0019 0.0014 0.0227
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0127 0.0103
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0794 0.2184
Echinococcus multilocularis carboxylesterase 5A 0.0068 0.0404 0.0415
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0036 0.015 0.0148
Schistosoma mansoni bromodomain containing protein 0.0134 0.0932 0.0956
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0169 0.0222
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0111 0.0747 0.0815
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0063 0.0065
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0377 0.4046
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0466 0.5002
Loa Loa (eye worm) jmjC domain-containing protein 0.0111 0.0745 0.0733
Loa Loa (eye worm) hypothetical protein 0.0038 0.0169 0.0156
Trichomonas vaginalis esterase, putative 0.0115 0.0776 0.2134
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0794 0.3268
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0111 0.0747 0.0815
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0169 0.0174
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0278 0.0274
Leishmania major pantothenate kinase subunit, putative 0.0031 0.0109 0.0116
Echinococcus multilocularis pyruvate kinase 0.0026 0.0072 0.0074
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0169 0.0174
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0087 0.0552 0.0601
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0466 0.0459
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0127 0.0124
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0169 0.0174
Loa Loa (eye worm) MH2 domain-containing protein 0.0366 0.2765 0.2755
Loa Loa (eye worm) hypothetical protein 0.042 0.3195 0.3185
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.1049 0.1075
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.011 0.0736 0.0732
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0241 0.0654
Trypanosoma cruzi PAB1-binding protein , putative 0.0134 0.0931 0.0994
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0081 0.051 0.0523
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0014 0.0027
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0169 0.0166
Leishmania major hypothetical protein, conserved 0.0031 0.0114 0.012
Trypanosoma cruzi ISWI complex protein 0.0031 0.0114 0.0108
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.0088 0.0951
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.051 0.0506
Leishmania major hypothetical protein, conserved 0.0028 0.0088 0.0093
Echinococcus multilocularis geminin 0.1247 0.9753 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Schistosoma mansoni nuclear hormone receptor 0.0081 0.051 0.0523
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0088 0.0075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0123 0.0109
Leishmania major pyruvate kinase 0.0033 0.0127 0.0136
Loa Loa (eye worm) hypothetical protein 0.009 0.0582 0.0569
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0116 0.1251
Schistosoma mansoni ran 0.0021 0.0032 0.0033
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0088 0.0091
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0607 0.0623
Loa Loa (eye worm) hypothetical protein 0.0457 0.3491 0.3482
Mycobacterium tuberculosis Probable esterase LipL 0.0115 0.0776 0.0847
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0048 0.0034
Toxoplasma gondii type I fatty acid synthase, putative 0.0077 0.0476 0.5111
Loa Loa (eye worm) jmjC domain-containing protein 0.018 0.1292 0.1279
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.1182 0.9241 1
Leishmania major acetyl-CoA synthetase, putative 0.0111 0.0747 0.0815
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0111 0.0747 0.074
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0127 0.0874 0.0896
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0372 0.2812 0.2883
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0169 0.0174
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0091 0.0847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0241 0.2586
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0133 0.0919 0.0942
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.051 0.0506
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0342
Brugia malayi PHD-finger family protein 0.0087 0.0556 0.0553
Echinococcus granulosus zinc finger protein 0.0045 0.0224 0.0229
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0259 0.0265
Brugia malayi hypothetical protein 0.0087 0.0553 0.055
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0607 0.1667
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0091 0.0094
Plasmodium vivax hypothetical protein, conserved 0.003 0.0105 0.1129
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.015 0.0148
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0047 0.0235 0.0228
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0306 0.2294 0.2291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0081 0.051 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0117 0.0793 0.0866
Brugia malayi photoreceptor-specific nuclear receptor 0.0081 0.051 0.0506
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0058 0.0325 0.0321
Echinococcus granulosus acetylcholinesterase 0.0068 0.0404 0.0415
Schistosoma mansoni cpg binding protein 0.0034 0.0135 0.0138
Echinococcus granulosus ecdysone induced protein 78C 0.0081 0.051 0.0523
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0081 0.051 0.0506
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0058 0.0325 0.0352
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0082 0.0068
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0776 0.2134
Echinococcus multilocularis AMP dependent ligase 0.0021 0.0034 0.0035
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0081 0.051 0.1185
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.0776 0.0826
Mycobacterium ulcerans acyl-CoA synthetase 0.0111 0.0747 0.074
Loa Loa (eye worm) hypothetical protein 0.0115 0.0776 0.0763
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.0794 0.0867
Toxoplasma gondii hypothetical protein 0.0094 0.061 0.6549
Loa Loa (eye worm) phosphofructokinase 0.0117 0.0794 0.0781
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.0088 0.0951
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0058 0.0325 0.0352
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0014 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Giardia lamblia GTOR 0.0036 0.015 0.2477
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0117 0.0793 0.086
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0117 0.0793 0.0866
Brugia malayi AMP-binding enzyme family protein 0.0111 0.0747 0.0743
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0466 0.5002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0076 0.0466 0.0507
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.062 0.0635
Loa Loa (eye worm) hypothetical protein 0.0076 0.0466 0.0452
Schistosoma mansoni cpg binding protein 0.0028 0.0091 0.0093
Brugia malayi Cytochrome P450 family protein 0.0022 0.0042 0.0038
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0111 0.0747 0.0794
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0127 0.0342
Brugia malayi conserved hypotetical protein 0.0038 0.0169 0.0166
Brugia malayi AMP-binding enzyme family protein 0.0111 0.0747 0.0743
Schistosoma mansoni transcription factor LCR-F1 0.032 0.2401 0.2462
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0111 0.0747 0.8023
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0014 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0081 0.051 0.0496
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0466 1
Leishmania major hypothetical protein, conserved 0.0134 0.0931 0.1017
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.002
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0088 0.0091
Loa Loa (eye worm) hypothetical protein 0.0038 0.0169 0.0156
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0088 0.0081
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0082 0.0084
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0036 0.015 0.149
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0026 0.0062
Entamoeba histolytica hypothetical protein 0.0049 0.0257 0.1018
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0116 0.1251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0116 0.0612
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.051 0.0523
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0115 0.0776 0.0847
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0127 0.0342
Brugia malayi hypothetical protein 0.0038 0.0169 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Brugia malayi exodeoxyribonuclease III family protein 0.0076 0.0466 0.0462
Trichomonas vaginalis antibiotic synthetase, putative 0.0111 0.0747 0.2053
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0081 0.051 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0026 0.0062
Mycobacterium ulcerans polyketide synthase Pks9 0.0038 0.0169 0.0163
Echinococcus granulosus cpg binding protein 0.0034 0.0135 0.0138
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0111 0.0747 0.0794
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0111 0.0747 0.0815
Echinococcus multilocularis lysine specific demethylase 5A 0.0105 0.0701 0.0719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.015 0.0405
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0036 0.015 0.0572
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0023 0.0045 0.0479
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0374 0.1509
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0061 0.0353 0.0383
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0043 0.0206 0.0211
Loa Loa (eye worm) hypothetical protein 0.0038 0.0169 0.0156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0372 0.2812 0.2883
Brugia malayi RNA, U transporter 1 0.0081 0.0508 0.0504
Loa Loa (eye worm) hypothetical protein 0.0033 0.0127 0.0114
Loa Loa (eye worm) hypothetical protein 0.0081 0.051 0.0496
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0063 0.0065
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0169 0.0156
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0116 0.0311
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0794 0.0781
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0607 0.0643
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0607 0.1462
Echinococcus granulosus flap endonuclease 1 0.0027 0.0082 0.0084
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0048 0.0248 0.0262
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0058 0.0325 0.0346
Schistosoma mansoni smad1 5 8 and 0.0025 0.0063 0.0065
Schistosoma mansoni hypothetical protein 0.0042 0.02 0.0205
Loa Loa (eye worm) steroid hormone receptor 0.0081 0.051 0.0496
Loa Loa (eye worm) PHD-finger family protein 0.0087 0.0556 0.0543

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 76.8 % Inhibition of PrPSc formation in mouse SMB cells at 1 uM after 5 days by MTT assay relative to control ChEMBL. 17305326
RUmax (binding) = 0 % Binding affinity at human PrPC at 40 uM by SPR assay ChEMBL. 17305326
RUmax (binding) = 0 % Binding affinity at mouse PrPC at 40 uM by SPR assay ChEMBL. 17305326
RUmax (binding) = 0 % Binding affinity at human PrPC at 40 uM by SPR assay ChEMBL. 17305326
RUmax (binding) = 0 % Binding affinity at mouse PrPC at 40 uM by SPR assay ChEMBL. 17305326

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.