Detailed information for compound 43201

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 207.077 | Formula: C8H10Cl2NO-
  • H donors: 2 H acceptors: 1 LogP: 2.77 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCc1c(O)ccc(c1C)Cl.[Cl-]
  • InChi: 1S/C8H10ClNO.ClH/c1-5-6(4-10)8(11)3-2-7(5)9;/h2-3,11H,4,10H2,1H3;1H/p-1
  • InChiKey: LAZJCJKMPSCGLN-UHFFFAOYSA-M  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0003 0.0003
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0005 0.0072
Schistosoma mansoni inositol monophosphatase 0.0037 0.0016 0.0026
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0012 0.0018
Mycobacterium tuberculosis Conserved protein 0.0108 0.0071 0.1341
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0128 0.0086 0.0139
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0012 0.0018
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0003 0.0003
Schistosoma mansoni cpg binding protein 0.0098 0.0063 0.0102
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0035 0.0015 0.0576
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0019 0.0066
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0035 0.0015 0.0576
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0003 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0637 0.0478 0.719
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0012 0.0018
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0202 0.0143 0.2731
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0019 0.0217
Loa Loa (eye worm) GMP reductase 0.005 0.0026 0.0386
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0016 0.0187
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0035 0.0015 0.0576
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0019 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0043 0.0154
Mycobacterium ulcerans beta-lactamase 0.0108 0.0071 0.3234
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0035 0.0015 0.0258
Leishmania major pyruvate kinase 0.0033 0.0013 0.0042
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0035 0.0015 0.0258
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0035 0.0015 0.0049
Brugia malayi steroid hormone receptor 0.0031 0.0012 0.0016
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0016 0.2222
Schistosoma mansoni Smad4 0.0019 0.0003 0.0003
Onchocerca volvulus 0.0105 0.0069 0.0066
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0021 0.0033
Echinococcus granulosus dnaJ subfamily B 0.1321 0.1005 0.1627
Brugia malayi Pre-SET motif family protein 0.0128 0.0086 0.0118
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0033
Toxoplasma gondii IMP dehydrogenas 0.0113 0.0075 0.0272
Brugia malayi Cathepsin L-like precursor 0.0019 0.0002 0.0002
Leishmania major cathepsin L-like protease 0.0019 0.0002 0.0003
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.003 0.044
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0003 0.0003
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0003 0.0059
Trypanosoma brucei GMP reductase 0.0113 0.0075 0.0269
Echinococcus granulosus lamin 0.0028 0.0009 0.0014
Trypanosoma brucei unspecified product 0.0019 0.0003 0.0004
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.0066 0.0106
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0013 0.0042
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0012 0.0018
Trypanosoma brucei polo-like protein kinase 0.0101 0.0066 0.0236
Brugia malayi Protein kinase domain containing protein 0.003 0.0011 0.0014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0171
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.0066 0.0236
Schistosoma mansoni alpha-glucosidase 0.0156 0.0108 0.0174
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0035 0.0015 0.0576
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0035 0.0015 0.0576
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0004 0.0021
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0113 0.0075 0.012
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0002 0.0002
Schistosoma mansoni inositol monophosphatase 0.0037 0.0016 0.0026
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.005 0.0026 0.0897
Loa Loa (eye worm) hypothetical protein 0.0046 0.0023 0.0345
Trichomonas vaginalis esterase, putative 0.0108 0.0071 0.0908
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0224 0.016 1
Echinococcus multilocularis lamin 0.0028 0.0009 0.0014
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0011 0.0036
Onchocerca volvulus Putative GMP reductase 0.005 0.0026 0.0024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0002 0.0002
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0013 0.0187
Brugia malayi calpain family protein 1 0.0066 0.0039 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0066 0.084
Echinococcus granulosus microtubule associated protein 2 0.803 0.6172 1
Echinococcus multilocularis lamin dm0 0.0028 0.0009 0.0014
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0019 0.0217
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0002 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0031 0.0011 0.0036
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0003 0.0033
Loa Loa (eye worm) hypothetical protein 0.003 0.0011 0.0151
Brugia malayi F/Y-rich N-terminus family protein 0.0043 0.0021 0.0028
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0035 0.0015 0.0049
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0121 0.0081 0.0131
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0026 0.004
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0031 0.0011 0.0018
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0043 0.0154
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0002 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0011 0.0036
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0016 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0086 0.0139
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0035 0.0015 0.0258
Echinococcus multilocularis geminin 0.0374 0.0275 0.0445
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0003 0.0005
Schistosoma mansoni alpha-glucosidase 0.0156 0.0108 0.0174
Echinococcus granulosus calpain 5 0.002 0.0003 0.0004
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.005 0.0026 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.0131 0.0211
Loa Loa (eye worm) ctsf protein 0.0019 0.0002 0.0027
Brugia malayi Kringle domain containing protein 0.003 0.0011 0.0014
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0035 0.0015 0.0576
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0003 0.0003
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0035 0.0015 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0003 0.0005
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0012 0.0018
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0113 0.0075 0.012
Echinococcus multilocularis tissue type plasminogen activator 0.003 0.0011 0.0016
Brugia malayi Thioredoxin reductase 0.0088 0.0056 0.0076
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0002 0.0003
Mycobacterium tuberculosis Probable dehydrogenase 0.0202 0.0143 0.2731
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0066 0.084
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0021 0.0308
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0017 0.0027
Leishmania major cathepsin L-like protease 0.0072 0.0043 0.0154
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0172
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0019 0.0063
Loa Loa (eye worm) histone methyltransferase 0.0033 0.0013 0.0194
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0013 0.0011
Trichomonas vaginalis mercuric reductase, putative 0.0031 0.0011 0.0119
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.0066 0.0236
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0071 0.0908
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0003 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0002 0.0002
Echinococcus multilocularis cysteine protease 0.0019 0.0002 0.0003
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0071 0.1341
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0016 0.0055
Echinococcus granulosus calpain A 0.002 0.0003 0.0004
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.0066 1
Giardia lamblia Pyruvate kinase 0.0033 0.0013 0.0045
Loa Loa (eye worm) calpain 0.002 0.0003 0.0035
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0113 0.0075 0.3413
Echinococcus granulosus survival motor neuron protein 1 0.051 0.038 0.0615
Schistosoma mansoni hypothetical protein 0.0374 0.0275 0.0445
Brugia malayi Inositol-1 0.0037 0.0016 0.0022
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0035 0.0015 0.0576
Leishmania major hypothetical protein, conserved 0.0077 0.0047 0.0166
Brugia malayi intermediate filament protein 0.0028 0.0009 0.0012
Schistosoma mansoni hypothetical protein 0.003 0.0011 0.0016
Mycobacterium leprae putative cytochrome p450 0.0035 0.0015 0.0129
Echinococcus granulosus cathepsin l1 0.0019 0.0002 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0003 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0043 0.0154
Loa Loa (eye worm) hypothetical protein 0.0128 0.0086 0.129
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0071 0.1341
Brugia malayi Cathepsin L-like precursor 0.0019 0.0002 0.0002
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0035 0.0015 0.0258
Mycobacterium ulcerans lipase LipD 0.0108 0.0071 0.3234
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0012 0.0018
Trichomonas vaginalis glutaminase, putative 0.0293 0.0214 0.2797
Plasmodium falciparum thioredoxin reductase 0.0031 0.0011 0.0042
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0069 0.0041 0.0066
Schistosoma mansoni Smad4 0.0019 0.0003 0.0003
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0013 0.0141
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0026 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.0131 0.0211
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0014 0.0022
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0067 0.0107
Echinococcus granulosus histone lysine methyltransferase setb 0.0128 0.0086 0.0139
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0004 0.0021
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0002 0.0002
Echinococcus granulosus GPCR family 2 0.0049 0.0026 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0012 0.0016
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0028 0.0009 0.0014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0026 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0043 0.0154
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0071 0.0114
Toxoplasma gondii cytochrome p450 superfamily protein 0.0035 0.0015 0.0052
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0001 0.0003
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0003 0.0005
Leishmania major kinesin, putative 0.002 0.0003 0.0005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0026 0.004
Brugia malayi isocitrate dehydrogenase 0.0018 0.0002 0.0001
Leishmania major telomerase reverse transcriptase, putative 0.3551 0.2723 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0031 0.0011 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0012 0.0172
Loa Loa (eye worm) hypothetical protein 0.0066 0.0039 0.0573
Echinococcus multilocularis pyruvate kinase 0.0026 0.0008 0.0012
Loa Loa (eye worm) glutaminase 2 0.0293 0.0214 0.321
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0113 0.0075 0.3413
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0067 0.0107
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0879 0.0665 1
Brugia malayi Cytochrome P450 family protein 0.0035 0.0015 0.002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0026 0.004
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0003 0.0033
Echinococcus multilocularis dnaJ subfamily B 0.1321 0.1005 0.1627
Leishmania major trypanothione reductase 0.0088 0.0056 0.0199
Leishmania major guanosine monophosphate reductase 0.0113 0.0075 0.0269
Brugia malayi MH2 domain containing protein 0.0637 0.0478 0.0657
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0035 0.0015 0.0049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0004 0.0021
Echinococcus granulosus cpg binding protein 0.0098 0.0063 0.0102
Loa Loa (eye worm) glutaminase 0.0293 0.0214 0.321
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0055 0.003 0.1281
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0172
Giardia lamblia Telomerase catalytic subunit 0.3551 0.2723 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0035 0.0015 0.0258
Leishmania major cytochrome p450-like protein 0.0035 0.0015 0.0049
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0128 0.0086 0.0314
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0202 0.0143 0.8824
Loa Loa (eye worm) cytochrome P450 0.0035 0.0015 0.0216
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0071 0.3234
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0083 0.0134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.0131 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0043 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0012 0.0016
Schistosoma mansoni cpg binding protein 0.0093 0.0059 0.0095
Brugia malayi Cytochrome P450 family protein 0.0119 0.008 0.0109
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0003 0.0003
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0012 0.0171
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0071 0.1341
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0003 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0012 0.0172
Echinococcus multilocularis tumor protein p63 0.1047 0.0794 0.1286
Brugia malayi beta-lactamase family protein 0.0108 0.0071 0.0097
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.0131 0.0211
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0016 0.0055
Onchocerca volvulus 0.0093 0.0059 0.0057
Toxoplasma gondii thioredoxin reductase 0.0088 0.0056 0.0202
Toxoplasma gondii histone lysine methyltransferase SET1 0.018 0.0127 0.0463
Loa Loa (eye worm) hypothetical protein 0.0046 0.0023 0.0345
Echinococcus granulosus mixed lineage leukemia protein mll 0.0028 0.0009 0.0014
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.005 0.0026 0.1112
Echinococcus granulosus dna polymerase kappa 0.0019 0.0003 0.0004
Entamoeba histolytica hypothetical protein 0.0075 0.0046 0.6857
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0021
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0016 0.0187
Trypanosoma brucei calpain-like protein, putative 0.002 0.0003 0.0005
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0035 0.0015 0.0258
Entamoeba histolytica calpain large subunit domain III containing protein 0.002 0.0003 0.0085
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0172
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0071 0.0908
Plasmodium vivax vivapain-2 0.0019 0.0002 0.0009
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0012 0.0018
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0002 0.0001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.0107 0.1605
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0012 0.0018
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0202 0.0143 0.2731
Brugia malayi Cathepsin L-like precursor 0.0019 0.0002 0.0002
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0003 0.0004
Trypanosoma brucei telomerase reverse transcriptase 0.3551 0.2723 1
Onchocerca volvulus 0.0128 0.0086 0.0084
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0009 0.0128
Echinococcus granulosus thioredoxin glutathione reductase 0.0089 0.0056 0.009
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0128 0.0086 0.0139
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0009 0.0128
Echinococcus multilocularis thioredoxin glutathione reductase 0.0089 0.0056 0.009
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0012 0.0016
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0031 0.0011 0.0018
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0021 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0083 0.3811
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.0131 0.0211
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0021 0.0034
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0012 0.0041
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0013 0.0017
Brugia malayi cytochrome P450 0.0035 0.0015 0.002
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0035 0.0015 0.0258
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0113 0.0075 1
Brugia malayi MH2 domain containing protein 0.0019 0.0003 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0071 0.0114
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0009 0.0012
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.005 0.0026 0.0035
Echinococcus multilocularis cpg binding protein 0.0098 0.0063 0.0102
Echinococcus granulosus tumor protein p63 0.1047 0.0794 0.1286
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0066 0.084
Leishmania major cathepsin L-like protease 0.0019 0.0002 0.0003
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0035 0.0015 0.0576
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0047 0.0166
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0086 0.0139
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0155 0.0107 0.1605
Entamoeba histolytica protein kinase, putative 0.002 0.0003 0.0125
Toxoplasma gondii NADPH-glutathione reductase 0.0031 0.0011 0.0039
Schistosoma mansoni lamin 0.0028 0.0009 0.0014
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0011 0.0036
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0071 0.1341
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0026 0.0376
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.0083 0.0134
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0071 0.0908
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0063 0.0036 0.1584
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0012 0.0018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0185 0.0131 0.0179
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0011 0.0036
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0011 0.0036
Plasmodium falciparum telomerase reverse transcriptase 0.3551 0.2723 1
Entamoeba histolytica hypothetical protein 0.0075 0.0046 0.6857
Schistosoma mansoni alpha glucosidase 0.004 0.0019 0.003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0011 0.0036
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0047 0.0169
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0002 0.0027
Brugia malayi hypothetical protein 0.0075 0.0046 0.0062
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0012 0.0018
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.0616 0.0998
Onchocerca volvulus 0.0031 0.0012 0.001
Loa Loa (eye worm) fibroinase 0.0019 0.0002 0.0027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.0131 0.0211
Loa Loa (eye worm) hypothetical protein 0.0108 0.0071 0.106
Loa Loa (eye worm) hypothetical protein 0.0106 0.0069 0.1036
Plasmodium falciparum cysteine repeat modular protein 1 0.003 0.0011 0.0039
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0031 0.0011 0.0042
Brugia malayi Cathepsin L-like precursor 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0172
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0012 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0201 0.0143 0.0231
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0004 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0012 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0011 0.0036
Plasmodium vivax vivapain-2 0.0019 0.0002 0.0009
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.0127 0.0206
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0187
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0035 0.0015 0.0576
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0066 0.0106
Schistosoma mansoni calpain C (C02 family) 0.002 0.0003 0.0004
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.0165 0.2469
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0113 0.0075 0.4193
Onchocerca volvulus 0.0104 0.0068 0.0065
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0012 0.0172
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.003 0.044
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0011 0.0036
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0013 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0012 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0002 0.0003
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0019 0.003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0033 0.0013 0.0021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0021 0.0033
Trypanosoma brucei calpain-like protein, putative 0.002 0.0003 0.0005
Onchocerca volvulus 0.0108 0.0071 0.0069
Loa Loa (eye worm) hypothetical protein 0.0066 0.0039 0.0573
Brugia malayi CXXC zinc finger family protein 0.0093 0.0059 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0021
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.0107 0.0147
Trypanosoma brucei kinesin, putative 0.002 0.0003 0.0005
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0003 0.0004
Mycobacterium ulcerans glutaminase 0.0293 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0172
Mycobacterium tuberculosis Probable reductase 0.0202 0.0143 0.2731
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0031 0.0011 0.0018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.0083 0.03
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0003 0.0004
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.0066 0.0064
Leishmania major pyruvate kinase 0.0033 0.0013 0.0042
Schistosoma mansoni hypothetical protein 0.0049 0.0026 0.004
Schistosoma mansoni survival motor neuron protein 0.0104 0.0068 0.0109
Brugia malayi hypothetical protein 0.051 0.038 0.0523
Schistosoma mansoni calpain-7 (C02 family) 0.0023 0.0005 0.0008
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0031 0.0011 0.0409
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0043 0.0154
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0046 0.0073
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.0083 0.0134
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0019 0.0217
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0047 0.0172
Schistosoma mansoni cellular tumor antigen P53 0.0153 0.0106 0.0171
Trypanosoma brucei cytochrome P450, putative 0.0055 0.003 0.0104
Echinococcus multilocularis cysteine protease 0.0019 0.0002 0.0003
Schistosoma mansoni coup transcription factor 0.0031 0.0012 0.0018
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0113 0.0075 0.0102
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0035 0.0015 0.0576
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0003 0.0023
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0019 0.0217
Plasmodium vivax glutathione reductase, putative 0.0088 0.0056 0.0205
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0128 0.0086 0.0139
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0012 0.0018
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0031 0.0011 0.019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0185 0.0131 0.1957
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0035 0.0015 0.0258
Loa Loa (eye worm) inositol-1 0.0037 0.0016 0.024
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0026 0.004
Schistosoma mansoni cpg binding protein 0.0098 0.0063 0.0102
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0013 0.0486
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0035 0.0015 0.0576
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0071 0.0261
Giardia lamblia Kinase, PLK 0.0101 0.0066 0.0239
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0035 0.0015 0.0258
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0012 0.0172
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0071 0.0114
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0002 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0071 0.0908
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0012 0.0041
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0035 0.0015 0.0576
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0031 0.011
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0039 0.0136
Mycobacterium tuberculosis Conserved protein 0.0108 0.0071 0.1341
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0016 0.0026
Leishmania major DNA polymerase eta, putative 0.0019 0.0003 0.0004
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0013 0.0011
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0013 0.0187
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0032
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0104 0.0068 0.0109
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0005 0.0006
Schistosoma mansoni smad 0.0019 0.0003 0.0003
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.0011 0.0015
Onchocerca volvulus 0.0153 0.0106 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0086 0.0139
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0031 0.0011 0.0042
Loa Loa (eye worm) TK/ROR protein kinase 0.003 0.0011 0.0151
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0016 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0012 0.0016
Brugia malayi calpain 7 0.002 0.0003 0.0003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0016 0.0055
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0071 0.0097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0017 0.0027
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0031 0.0011 0.0036
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0019 0.0217
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0012 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0012 0.0016
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0035 0.0015 0.0576
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0019 0.0217
Schistosoma mansoni smad 0.0043 0.0021 0.0033
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0012 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0021
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0002 0.0003
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.0127 0.0206
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.3551 0.2723 1
Plasmodium vivax SET domain protein, putative 0.0128 0.0086 0.0317
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0035 0.0015 0.0258
Loa Loa (eye worm) hypothetical protein 0.0108 0.0071 0.106
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0069 0.0041 0.0066
Entamoeba histolytica hypothetical protein 0.0075 0.0046 0.6857
Treponema pallidum NADH oxidase 0.0031 0.0011 0.5
Echinococcus granulosus tissue type plasminogen activator 0.003 0.0011 0.0016
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0002 0.0003
Brugia malayi follicle stimulating hormone receptor 0.023 0.0165 0.0226
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0113 0.0075 0.0269
Echinococcus multilocularis calpain family protein 1, d 0.0046 0.0023 0.0037
Mycobacterium tuberculosis Possible penicillin-binding protein 0.069 0.0519 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0002 0.0002
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0002 0.0003
Echinococcus granulosus Smad4 0.0043 0.0021 0.0033
Brugia malayi glutathione reductase 0.0088 0.0056 0.0076
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0003 0.0005
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0013 0.0042
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0013 0.0187
Echinococcus multilocularis GPCR, family 2 0.0049 0.0026 0.004
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0002 0.0003
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0071 0.3937
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0003 0.0005
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0003 0.0004
Chlamydia trachomatis pyruvate kinase 0.0033 0.0013 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0071 0.106
Plasmodium falciparum thioredoxin reductase 0.0088 0.0056 0.0205
Leishmania major hypothetical protein, conserved 0.0108 0.0071 0.0255
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0071 0.1341
Loa Loa (eye worm) calpain family protein 1 0.0046 0.0023 0.0345
Brugia malayi beta-lactamase 0.0108 0.0071 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0012 0.0172
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0019 0.0063
Echinococcus multilocularis 0.0035 0.0015 0.0023
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0013 0.0045
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0003 0.0004
Brugia malayi jmjC domain containing protein 0.0102 0.0067 0.0091
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0031 0.0011 0.0036
Schistosoma mansoni hypothetical protein 0.0035 0.0015 0.0023
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0043 0.0154
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.0066 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0021
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0003 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0043 0.0154
Echinococcus multilocularis calpain A 0.0069 0.0041 0.0066
Schistosoma mansoni hypothetical protein 0.0049 0.0026 0.004
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0035 0.0015 0.0576
Trypanosoma cruzi kinesin, putative 0.002 0.0003 0.0005
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0005 0.0006
Leishmania major cathepsin L-like protease 0.0019 0.0002 0.0003
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.0066 0.0983
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0014 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0043 0.0154
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0019 0.0274
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0113 0.0075 0.0269
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0003 0.0005
Onchocerca volvulus 0.0028 0.0009 0.0007
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0003 0.0005
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0012 0.0018
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0003 0.0004
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0002 0.0003
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0043 0.0154
Trypanosoma cruzi cytochrome P450, putative 0.0055 0.003 0.0104
Echinococcus granulosus cytochrome P450 2K1 0.0035 0.0015 0.0023
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0202 0.0143 0.2731
Schistosoma mansoni lamin 0.0028 0.0009 0.0014
Brugia malayi calpain family protein 1 0.0066 0.0039 0.0052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0027
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0013 0.0017
Echinococcus multilocularis peregrin 0.0031 0.0012 0.0018
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0035 0.0015 0.0576
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0021 0.0033
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0031 0.0011 0.0042
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0003 0.0003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0009 0.0014
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0071 0.3234
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0035 0.0015 0.0258
Brugia malayi MH1 domain containing protein 0.0043 0.0021 0.0028
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0021 0.0311
Trichomonas vaginalis glutathione reductase, putative 0.0031 0.0011 0.0119
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0012 0.0044
Onchocerca volvulus Alhambra homolog 0.0031 0.0012 0.001
Plasmodium falciparum phd finger protein, putative 0.0031 0.0012 0.0044
Brugia malayi nuclear hormone receptor 0.0031 0.0012 0.0016
Leishmania major DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0035 0.0015 0.0258
Schistosoma mansoni hypothetical protein 0.0374 0.0275 0.0445
Echinococcus multilocularis calpain 0.002 0.0003 0.0004
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0003 0.0005
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0021 0.0034
Leishmania major cathepsin L-like protease 0.0019 0.0002 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0012 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0043 0.0154
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0013 0.0048
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0031 0.0011 0.0409
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0047 0.0172
Mycobacterium ulcerans hypothetical protein 0.0108 0.0071 0.3234
Trypanosoma brucei antigen, putative 0.002 0.0003 0.0005
Trypanosoma brucei calpain-like protein, putative 0.002 0.0003 0.0005
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0003 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0011 0.0036
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0003 0.0004
Loa Loa (eye worm) Smad1 0.0043 0.0021 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0021
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0086
Brugia malayi hypothetical protein 0.0049 0.0026 0.0035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0011 0.0036
Trichomonas vaginalis set domain proteins, putative 0.1 0.0758 1
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0012 0.0018
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0071 0.0255
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0012 0.0016
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.0066 0.009
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0012 0.0016
Echinococcus granulosus intermediate filament protein 0.0028 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.0033
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.0066 0.0106
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0028 0.0009 0.0128
Schistosoma mansoni hypothetical protein 0.0034 0.0014 0.0022
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0012 0.0018
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0019 0.2585
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.0083 0.1576
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0033 0.0013 0.0021
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0035 0.0015 0.0258
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0012 0.0172
Schistosoma mansoni hypothetical protein 0.0049 0.0026 0.004
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0035 0.0015 0.0049
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0021 0.0033
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0049 0.0026 0.0376
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0012 0.0018
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0019 0.2585
Echinococcus multilocularis pyruvate kinase 0.0033 0.0013 0.002
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0013 0.0011
Trichomonas vaginalis helicase, putative 0.0021 0.0004 0.0021
Brugia malayi PHD-finger family protein 0.0031 0.0012 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0021 0.0033
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0003 0.0004
Entamoeba histolytica hypothetical protein 0.0075 0.0046 0.6857
Brugia malayi Cytochrome P450 family protein 0.0055 0.003 0.004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0012 0.0018
Brugia malayi jmjC domain containing protein 0.0043 0.0021 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0012 0.0016
Leishmania major cytochrome p450-like protein 0.0035 0.0015 0.0049
Echinococcus granulosus calpain 0.002 0.0003 0.0004
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0013 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0021
Trypanosoma cruzi GMP reductase 0.0113 0.0075 0.0269
Schistosoma mansoni kinase 0.0052 0.0027 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0011 0.0036
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0035 0.0015 0.0049
Brugia malayi calpain 5 0.002 0.0003 0.0003
Plasmodium falciparum glutathione reductase 0.0031 0.0011 0.0042
Giardia lamblia NADH oxidase lateral transfer candidate 0.0031 0.0011 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0003 0.0004
Echinococcus multilocularis smad 0.0043 0.0021 0.0033
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0071 0.0114
Brugia malayi MH1 domain containing protein 0.0043 0.0021 0.0028
Loa Loa (eye worm) calpain family protein 1 0.0066 0.0039 0.0573
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0083 0.3811
Mycobacterium tuberculosis Probable oxidoreductase 0.0224 0.016 0.3066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0012 0.0172
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0031 0.0011 0.0409
Echinococcus granulosus pyruvate kinase 0.0033 0.0013 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0066 0.084
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0003 0.0003
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0002 0.0003
Echinococcus multilocularis pyruvate kinase 0.0033 0.0013 0.002
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0071 0.1341
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0113 0.0075 0.0269
Brugia malayi MH1 domain containing protein 0.0024 0.0006 0.0008
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0002 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0035 0.0015 0.0258
Echinococcus multilocularis microtubule associated protein 2 0.803 0.6172 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0002 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0002 0.0002
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0035 0.0015 0.0576
Loa Loa (eye worm) calpain 5 0.002 0.0003 0.0035
Giardia lamblia DINP protein human, muc B family 0.0019 0.0003 0.0007
Brugia malayi Cathepsin L-like precursor 0.0019 0.0002 0.0002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0224 0.016 0.3066
Loa Loa (eye worm) transcription factor SMAD2 0.0637 0.0478 0.719
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0083 0.0134
Echinococcus granulosus peregrin 0.0031 0.0012 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0026 0.0319
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0113 0.0075 0.0275
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0016 0.0807
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Echinococcus granulosus dna polymerase eta 0.0019 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Leishmania major cathepsin L-like protease 0.0019 0.0002 0.0003
Onchocerca volvulus 0.003 0.0011 0.0008
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0035 0.0015 0.0258
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0021 0.0033
Schistosoma mansoni calpain-7 (C02 family) 0.0023 0.0005 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0012 0.0018
Schistosoma mansoni jumonji domain containing protein 0.0081 0.005 0.0081
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0063 0.0036 0.0672
Loa Loa (eye worm) hypothetical protein 0.0108 0.0071 0.106
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0066 0.084
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0031 0.0011 0.0036
Leishmania major hypothetical protein, conserved 0.003 0.0011 0.0033
Schistosoma mansoni glutaminase 0.0293 0.0214 0.0345
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0002 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0012 0.0172
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0069 0.0041 0.0066
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0012 0.0018
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0021 0.0311
Brugia malayi hypothetical protein 0.0077 0.0047 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Plasmodium falciparum pyruvate kinase 0.0033 0.0013 0.0048
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0002 0.0027
Plasmodium vivax calpain, putative 0.002 0.0003 0.0011
Schistosoma mansoni pyruvate kinase 0.0033 0.0013 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0004 0.0021
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0113 0.0075 0.0275
Leishmania major cytochrome p450-like protein 0.0055 0.003 0.0104
Leishmania major cathepsin L-like protease 0.0072 0.0043 0.0154
Mycobacterium tuberculosis Conserved protein 0.0108 0.0071 0.1341
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0012 0.0018
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0013 0.023
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0047 0.0166
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0113 0.0075 0.0269
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0019 0.0063
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0069 0.0095
Loa Loa (eye worm) IMP dehydrogenase 1 0.0113 0.0075 0.1117
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0038 0.0557
Trypanosoma brucei glucosidase, putative 0.004 0.0019 0.0063
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0054 0.0029 0.043
Loa Loa (eye worm) CXXC zinc finger family protein 0.0093 0.0059 0.0883
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0035 0.0015 0.0258
Schistosoma mansoni hypothetical protein 0.0106 0.0069 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0043 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0001 0.0003
Onchocerca volvulus 0.0108 0.0071 0.0069
Brugia malayi Pre-SET motif family protein 0.0879 0.0665 0.0914
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0012 0.0018
Loa Loa (eye worm) CYP4Cod1 0.0055 0.003 0.044
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0013 0.0141
Loa Loa (eye worm) hypothetical protein 0.051 0.038 0.5717
Loa Loa (eye worm) hypothetical protein 0.0108 0.0071 0.106
Plasmodium vivax cysteine repeat modular protein 1, putative 0.003 0.0011 0.0039
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0031 0.0011 0.0036
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0035 0.0015 0.0576
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0002 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0011 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0035 0.0015 0.0258
Schistosoma mansoni smad1 5 8 and 0.0043 0.0021 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0012 0.0018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0012 0.0018
Trypanosoma cruzi cytochrome P450, putative 0.0055 0.003 0.0104
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0019 0.0217
Plasmodium vivax telomerase reverse transcriptase, putative 0.3551 0.2723 1
Echinococcus granulosus lamin dm0 0.0028 0.0009 0.0014
Onchocerca volvulus 0.0046 0.0023 0.0021
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0012 0.0018
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0016 0.0055
Loa Loa (eye worm) hypothetical protein 0.0153 0.0106 0.1585
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0172
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0047 0.0166
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0019 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0043 0.0154
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.0127 0.0175
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0003 0.0004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0012 0.0018
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0035 0.0015 0.0576
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0046 0.0073
Trypanosoma brucei calpain-like protein, putative 0.002 0.0003 0.0005
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0003 0.0005
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0202 0.0143 0.2731
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0035 0.0015 0.0258
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0003 0.0005
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0019 0.0025
Brugia malayi Bromodomain containing protein 0.0031 0.0012 0.0016
Schistosoma mansoni intermediate filament proteins 0.0028 0.0009 0.0014
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0002 0.0009
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0035 0.0015 0.0576
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0012 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Toxoplasma gondii RNA-directed DNA polymerase 0.3551 0.2723 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0071 0.1341
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0012 0.0018
Schistosoma mansoni hypothetical protein 0.0049 0.0026 0.004
Schistosoma mansoni Smad4 0.0043 0.0021 0.0033
Brugia malayi Smad1 0.0043 0.0021 0.0028
Brugia malayi nuclear receptor NHR-88 0.0031 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0077 0.0047 0.0696
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0003 0.0005
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0088 0.0056 0.1048
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.0068 0.0093
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0066 0.084
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0071 0.0255
Schistosoma mansoni smad1 5 8 and 0.0043 0.0021 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0012 0.0016
Brugia malayi MH2 domain containing protein 0.0043 0.0021 0.0028
Onchocerca volvulus 0.0028 0.0009 0.0007
Brugia malayi GMP reductase 0.005 0.0026 0.0035
Leishmania major inosine-5-monophosphate dehydrogenase 0.0113 0.0075 0.0269
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0002 0.0006
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0016 0.0651
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.0131 0.0211
Loa Loa (eye worm) hypothetical protein 0.0108 0.0071 0.106
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Brugia malayi MH1 domain containing protein 0.0024 0.0006 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0071 0.0255
Toxoplasma gondii cathepsin CPL 0.0019 0.0002 0.0006
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0047 0.0172
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.3551 0.2723 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0013 0.0033
Echinococcus granulosus geminin 0.0374 0.0275 0.0445
Schistosoma mansoni hypothetical protein 0.1321 0.1005 0.1627
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0172
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0113 0.0075 0.012
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0035 0.0015 0.0258
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0012 0.0018
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0002 0.0015
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0043 0.0154
Echinococcus multilocularis hypothetical protein 0.002 0.0003 0.0004
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0019 0.0217
Mycobacterium leprae Conserved hypothetical protein 0.0035 0.0015 0.0129
Loa Loa (eye worm) thioredoxin reductase 0.0088 0.0056 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0004 0.0021
Echinococcus granulosus calpain 7 C02 family 0.002 0.0003 0.0004
Toxoplasma gondii ABC1 family protein 0.0108 0.0071 0.0258
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0113 0.0075 0.1414
Loa Loa (eye worm) glutathione reductase 0.0088 0.0056 0.0832
Trypanosoma brucei trypanothione reductase 0.0088 0.0056 0.0199
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0005 0.0472
Giardia lamblia PHD finger protein 15 0.0031 0.0012 0.0041
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0069 0.0041 0.0066
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0083 0.3811
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0071 0.106
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.0127 0.0206
Loa Loa (eye worm) cytochrome P450 family protein 0.0119 0.008 0.1191
Trypanosoma cruzi kinesin, putative 0.002 0.0003 0.0005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0224 0.016 0.3066
Toxoplasma gondii kringle domain-containing protein 0.003 0.0011 0.0036
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.0083 0.0303
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0004 0.0021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.0107 0.0147
Brugia malayi glutaminase DH11.1 0.0293 0.0214 0.0293
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0066 0.084
Leishmania major cathepsin L-like protease 0.0072 0.0043 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0003 0.0005
Plasmodium vivax thioredoxin reductase, putative 0.0088 0.0056 0.0205
Echinococcus granulosus calpain A 0.0069 0.0041 0.0066
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0021 0.0033
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0011 0.0036
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0172
Schistosoma mansoni DNA polymerase eta 0.0019 0.0003 0.0004
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0039 0.0062
Echinococcus granulosus smad 0.0043 0.0021 0.0033
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.0127 0.1911
Brugia malayi ecdysteroid receptor 0.0031 0.0012 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0026 0.0319
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0013 0.0042
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0016 0.0187
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Trypanosoma cruzi GMP reductase 0.0113 0.0075 0.0269
Echinococcus multilocularis dna polymerase eta 0.0019 0.0003 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0012 0.0016
Loa Loa (eye worm) cysteine protease 0.0019 0.0002 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0003 0.0004
Trypanosoma cruzi trypanothione reductase, putative 0.0088 0.0056 0.0199
Echinococcus multilocularis survival motor neuron protein 1 0.051 0.038 0.0615
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0002 0.0002
Echinococcus granulosus pyruvate kinase 0.0033 0.0013 0.002
Echinococcus multilocularis Smad4 0.0043 0.0021 0.0033
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0012 0.0018
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0002 0.0003
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0003 0.0005
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0005 0.0072
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0012 0.001
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0071 0.0908
Mycobacterium leprae Probable lipase LipE 0.0108 0.0071 0.3937
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0012 0.0016
Onchocerca volvulus 0.1 0.0758 0.0756
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0004 0.0021
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0009 0.0014
Brugia malayi MH2 domain containing protein 0.0043 0.0021 0.0028
Loa Loa (eye worm) beta-lactamase 0.0108 0.0071 0.106
Schistosoma mansoni calpain (C02 family) 0.002 0.0003 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0043 0.0154
Loa Loa (eye worm) nuclear factor I 0.0024 0.0006 0.0086
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0035 0.0015 0.0576
Schistosoma mansoni pyruvate kinase 0.0033 0.0013 0.002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0046 0.0073
Brugia malayi beta-lactamase family protein 0.0108 0.0071 0.0097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0012 0.0018
Echinococcus multilocularis musashi 0.0028 0.0009 0.0014
Schistosoma mansoni hypothetical protein 0.0075 0.0046 0.0073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0004 0.0021
Schistosoma mansoni cytochrome P450 0.0035 0.0015 0.0023
Onchocerca volvulus 0.0108 0.0071 0.0069
Echinococcus multilocularis calpain 5 0.002 0.0003 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0012 0.0016
Plasmodium falciparum glutathione reductase 0.0088 0.0056 0.0205
Brugia malayi Telomerase reverse transcriptase 0.945 0.7265 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0012 0.001
Brugia malayi Cytochrome P450 family protein 0.0055 0.003 0.004
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0031 0.0011 0.0039
Schistosoma mansoni microtubule-associated protein tau 0.803 0.6172 1
Schistosoma mansoni smad1 5 8 and 0.0043 0.0021 0.0033

Activities

Activity type Activity value Assay description Source Reference
Diuretic activity (functional) = 250 Salidiuretic activity in dog following i.v. dosing at 5 mg/kg ChEMBL. 7452697

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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