Detailed information for compound 440871

Basic information

Technical information
  • TDR Targets ID: 440871
  • Name: 1-[2-phenyl-2-[[4-(trifluoromethyl)phenyl]met hoxy]ethyl]benzimidazole
  • MW: 396.405 | Formula: C23H19F3N2O
  • H donors: 0 H acceptors: 1 LogP: 5.13 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(c1ccc(cc1)COC(c1ccccc1)Cn1cnc2c1cccc2)(F)F
  • InChi: 1S/C23H19F3N2O/c24-23(25,26)19-12-10-17(11-13-19)15-29-22(18-6-2-1-3-7-18)14-28-16-27-20-8-4-5-9-21(20)28/h1-13,16,22H,14-15H2
  • InChiKey: QLLFDEZSGQZACU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-phenyl-2-[4-(trifluoromethyl)benzyl]oxy-ethyl]benzimidazole
  • 1H-Benzimidazole, 1-[2-phenyl-2-[[4-(trifluoromethyl)phenyl]methoxy]ethyl]-
  • AIDS-472018
  • AIDS472018

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Src42A 0.0732 0.0911 0.0804
Trichomonas vaginalis AGC family protein kinase 0.1494 0.2467 1
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.4779 0.918 0.9477
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0542 0.0522 0.0864
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0765 0.0977 0.9731
Schistosoma mansoni serine/threonine protein kinase 0.0509 0.0454 0.0745
Echinococcus multilocularis dual specificity 0.0617 0.0676 0.0796
Loa Loa (eye worm) hypothetical protein 0.0509 0.0454 0.0469
Echinococcus multilocularis casein kinase I alpha 0.0548 0.0535 0.0624
Brugia malayi protein kinase C3,putative 0.079 0.1028 0.1062
Trichomonas vaginalis AGC family protein kinase 0.041 0.0253 0.1004
Entamoeba histolytica protein kinase , putative 0.0735 0.0917 0.2565
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Schistosoma mansoni serine/threonine protein kinase 0.0378 0.0187 0.0282
Entamoeba histolytica PH domain containing protein kinase, putative 0.0808 0.1065 0.3017
Echinococcus multilocularis 0.0613 0.0666 0.0784
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.1016 0.149 0.139
Plasmodium vivax calcium-dependent protein kinase, putative 0.0509 0.0454 0.4068
Loa Loa (eye worm) hypothetical protein 0.0613 0.0666 0.0688
Loa Loa (eye worm) CDC7 protein kinase 0.0452 0.0339 0.035
Echinococcus multilocularis dual specificity 0.065 0.0743 0.0877
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0333 0.0095 0.036
Loa Loa (eye worm) hypothetical protein 0.0306 0.0041 0.0042
Giardia lamblia Kinase, STE STE20 0.0427 0.0286 0.0103
Brugia malayi Fibronectin type III domain containing protein 0.0611 0.0663 0.0684
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.1172 0.1809 0.218
Entamoeba histolytica protein kinase, putative 0.0419 0.027 0.0593
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0548 0.0535 0.0552
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0427 0.0286 0.0131
Trypanosoma cruzi cdc2-related kinase 3 0.06 0.064 0.2703
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0451 0.0335 0.0354
Brugia malayi Protein kinase domain containing protein 0.083 0.111 0.1146
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.065 0.0743 0.2321
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.094 0.1335 0.1601
Schistosoma mansoni serine/threonine protein kinase 0.1157 0.1779 0.3047
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.1157 0.1779 0.1683
Loa Loa (eye worm) hypothetical protein 0.0705 0.0854 0.0882
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1723 0.2936 0.2853
Toxoplasma gondii AGC kinase 0.0531 0.05 0.118
Echinococcus granulosus tyrosine protein kinase HCK 0.0695 0.0834 0.0727
Brugia malayi Variant SH3 domain containing protein 0.048 0.0396 0.0409
Trichomonas vaginalis AGC family protein kinase 0.1494 0.2467 1
Loa Loa (eye worm) hypothetical protein 0.0319 0.0066 0.0068
Schistosoma mansoni serine/threonine protein kinase 0.083 0.111 0.1885
Echinococcus granulosus aurora kinase A 0.0735 0.0917 0.0811
Brugia malayi P38 map kinase family protein 2 0.0805 0.1059 0.1093
Loa Loa (eye worm) hypothetical protein 0.1291 0.2052 0.2119
Echinococcus granulosus tyrosine protein kinase Btk29A 0.208 0.3664 0.3589
Loa Loa (eye worm) hypothetical protein 0.0542 0.0522 0.0539
Brugia malayi Protein kinase domain containing protein 0.3043 0.5632 0.5815
Schistosoma mansoni serine/threonine protein kinase 0.0777 0.1002 0.1696
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0509 0.0454 0.4068
Onchocerca volvulus 0.1647 0.2781 0.3167
Echinococcus multilocularis tyrosine protein kinase 0.1466 0.2409 0.2914
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0509 0.0454 0.0342
Echinococcus granulosus serine:threonine protein kinase NLK 0.0471 0.0376 0.0263
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0367 0.0164 0.0049
Brugia malayi phosphoinositide-dependent protein kinase I 0.041 0.0253 0.0261
Trichomonas vaginalis CMGC family protein kinase 0.065 0.0743 0.2993
Schistosoma mansoni serine/threonine protein kinase 0.0681 0.0807 0.1358
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0688 0.082 0.8034
Entamoeba histolytica protein kinase, putative 0.0367 0.0164 0.027
Entamoeba histolytica protein kinase domain containing protein 0.0735 0.0917 0.2565
Echinococcus granulosus cyclin dependent kinase 1 0.06 0.064 0.053
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0509 0.0454 0.0966
Schistosoma mansoni tyrosine kinase 0.1172 0.1809 0.3098
Echinococcus granulosus Vam6:Vps39 protein 0.0542 0.0522 0.0411
Onchocerca volvulus 0.0384 0.02 0.0142
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0509 0.0454 0.0342
Brugia malayi Immunoglobulin I-set domain containing protein 0.0378 0.0187 0.0193
Entamoeba histolytica protein kinase domain containing protein 0.065 0.0743 0.2034
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1172 0.1809 0.218
Echinococcus granulosus roundabout 2 0.0875 0.1202 0.1098
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0343 0.0116 0.0112
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0509 0.0454 0.4068
Entamoeba histolytica protein kinase, putative 0.1451 0.2379 0.7019
Echinococcus granulosus growth factor receptor bound protein 2 0.0487 0.041 0.0297
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Giardia lamblia Kinase, CAMK CAMKL 0.0451 0.0335 0.0419
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1577 0.2637 0.3191
Brugia malayi Protein kinase domain containing protein 0.06 0.064 0.0661
Echinococcus multilocularis hypothetical protein 0.0517 0.0471 0.0546
Brugia malayi Serine/threonine-protein kinase SULU 0.1125 0.1713 0.1769
Echinococcus granulosus mitogen activated protein kinase 3 0.0422 0.0276 0.0162
Echinococcus granulosus c src tyrosine kinase 0.0725 0.0896 0.0789
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.048 0.0396 0.0645
Plasmodium falciparum serine/threonine protein kinase 0.0419 0.027 0.0288
Schistosoma mansoni serine/threonine protein kinase 0.0419 0.027 0.0426
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0531 0.05 0.1839
Loa Loa (eye worm) TK/FER protein kinase 0.0524 0.0485 0.0501
Entamoeba histolytica PH domain containing protein kinase, putative 0.0574 0.0588 0.1563
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0735 0.0917 0.0811
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.1255 0.1979 0.1885
Entamoeba histolytica protein kinase 2, putative 0.0765 0.0977 0.2747
Echinococcus multilocularis serine:threonine protein kinase 38 0.085 0.1152 0.1377
Trichomonas vaginalis AGC family protein kinase 0.0735 0.0917 0.3701
Echinococcus multilocularis aurora kinase A 0.0735 0.0917 0.109
Echinococcus granulosus protein kinase 0.0774 0.0996 0.0891
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0976 0.1408 0.1454
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.1255 0.1979 0.2387
Schistosoma mansoni vesicular amine transporter 0.0531 0.05 0.0826
Schistosoma mansoni serine/threonine protein kinase 0.068 0.0804 0.1353
Echinococcus granulosus serine:threonine kinase SAD 1 0.0451 0.0335 0.0222
Leishmania major protein kinase, putative 0.0735 0.0917 0.4197
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0732 0.0911 0.1083
Loa Loa (eye worm) TK/FER protein kinase 0.0524 0.0485 0.0501
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.2507 0.4536 0.5513
Trichomonas vaginalis CAMK family protein kinase 0.0581 0.0602 0.242
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Brugia malayi Protein kinase domain containing protein 0.0311 0.005 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.1998 0.3497 0.603
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.094 0.1335 0.1378
Schistosoma mansoni protein kinase 0.22 0.3909 0.6746
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0531 0.05 0.3336
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.1172 0.1809 0.1713
Brugia malayi p70 ribosomal S6 kinase beta 0.1451 0.2379 0.2456
Schistosoma mansoni tyrosine kinase 0.2818 0.5173 0.8939
Entamoeba histolytica PH domain containing protein kinase, putative 0.0808 0.1065 0.3017
Loa Loa (eye worm) hypothetical protein 0.0665 0.0773 0.0798
Echinococcus multilocularis roundabout 2 0.0343 0.0116 0.0112
Echinococcus multilocularis serine:threonine protein kinase 3 0.1301 0.2072 0.2502
Brugia malayi Protein kinase domain containing protein 0.0976 0.1408 0.1454
Entamoeba histolytica protein kinase, putative 0.0695 0.0834 0.2313
Brugia malayi putative serine/threonine kinase SADA gamma 0.0451 0.0335 0.0346
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0451 0.0335 0.0497
Echinococcus granulosus serine/threonine protein kinase 0.0808 0.1065 0.0961
Loa Loa (eye worm) hypothetical protein 0.0531 0.05 0.0516
Brugia malayi Protein kinase domain containing protein 0.0524 0.0485 0.0501
Plasmodium falciparum protein kinase 5 0.06 0.064 0.5204
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.06 0.064 0.0661
Onchocerca volvulus Tyrosine kinase homolog 0.4501 0.8611 1
Trichomonas vaginalis AGC family protein kinase 0.041 0.0253 0.1004
Echinococcus granulosus STE20 serine:threonine protein kinase 0.2507 0.4536 0.4472
Echinococcus multilocularis cGMP dependent protein kinase 1 0.068 0.0804 0.0952
Schistosoma mansoni serine/threonine protein kinase 0.0531 0.05 0.0825
Schistosoma mansoni serine/threonine protein kinase 0.1125 0.1713 0.2932
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0451 0.0335 0.0346
Entamoeba histolytica protein kinase domain containing protein 0.0505 0.0446 0.1131
Loa Loa (eye worm) hypothetical protein 0.3043 0.5632 0.5815
Schistosoma mansoni kinase 0.1368 0.2209 0.3794
Schistosoma mansoni serine/threonine protein kinase 0.1093 0.1649 0.282
Trypanosoma cruzi polo-like protein kinase, putative 0.1182 0.183 1
Trichomonas vaginalis CMGC family protein kinase 0.0505 0.0446 0.1789
Schistosoma mansoni serine/threonine protein kinase 0.0681 0.0807 0.1358
Trichomonas vaginalis CAMK family protein kinase 0.1182 0.183 0.7409
Schistosoma mansoni serine/threonine protein kinase 0.0609 0.0659 0.1101
Entamoeba histolytica cell division protein kinase 2, putative 0.06 0.064 0.1722
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.2274 0.4061 0.4193
Echinococcus multilocularis tyrosine protein kinase Blk 0.097 0.1397 0.1677
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0509 0.0454 0.0525
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.065 0.0743 0.232
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0812 0.1073 0.4334
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0548 0.0535 0.0552
Trichomonas vaginalis CMGC family protein kinase 0.0422 0.0276 0.1099
Brugia malayi Egg laying defective protein 4 0.068 0.0804 0.083
Trichomonas vaginalis CMGC family protein kinase 0.0505 0.0446 0.1789
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0505 0.0446 0.0461
Brugia malayi Protein kinase domain containing protein 0.0977 0.1411 0.1457
Loa Loa (eye worm) hypothetical protein 0.1555 0.2591 0.2675
Trichomonas vaginalis STE family protein kinase 0.0427 0.0286 0.1138
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0531 0.05 0.4562
Brugia malayi SH2 domain containing protein 0.1539 0.256 0.2643
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0451 0.0335 0.0831
Echinococcus multilocularis rac serine:threonine kinase 0.0808 0.1065 0.1272
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0542 0.0522 0.0864
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.065 0.0743 0.0767
Schistosoma mansoni serine/threonine-protein kinase 0.0808 0.1065 0.1807
Brugia malayi Serine/threonine-protein kinase Pim-3 0.1787 0.3065 0.3165
Echinococcus multilocularis serine:threonine protein kinase N2 0.0658 0.076 0.0898
Echinococcus granulosus tyrosine protein kinase Fyn 0.1172 0.1809 0.1713
Trichomonas vaginalis AGC family protein kinase 0.0735 0.0917 0.3701
Brugia malayi hypothetical protein 0.0524 0.0485 0.0501
Trichomonas vaginalis STE family protein kinase 0.0433 0.03 0.1195
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Brugia malayi Tyrosine-protein kinase abl-1 0.1128 0.1719 0.1775
Schistosoma mansoni tyrosine kinase 0.1332 0.2137 0.3668
Trichomonas vaginalis CMGC family protein kinase 0.0505 0.0446 0.1789
Toxoplasma gondii histone kinase SNF1, putative 0.0451 0.0335 0.0409
Plasmodium vivax serine/threonine protein kinase, putative 0.0419 0.027 0.2075
Trichomonas vaginalis CMGC family protein kinase 0.0452 0.0339 0.1353
Echinococcus granulosus calcium dependent protein kinase 0.0345 0.0119 0.0003
Brugia malayi serine/threonine-protein kinase plk-2 0.1182 0.183 0.1889
Echinococcus multilocularis raf serine:threonine protein kinase 0.0453 0.034 0.0386
Entamoeba histolytica protein kinase, putative 0.0367 0.0164 0.027
Schistosoma mansoni tyrosine kinase 0.2292 0.4097 0.7071
Trypanosoma brucei protein kinase, putative 0.0422 0.0276 0.0088
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0735 0.0917 0.2565
Loa Loa (eye worm) hypothetical protein 0.0729 0.0904 0.0933
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0419 0.027 0.0279
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0427 0.0286 0.0643
Brugia malayi C1-like domain containing protein 0.1034 0.1526 0.1576
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0542 0.0522 0.0608
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0433 0.03 0.0186
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Echinococcus multilocularis tyrosine protein kinase Abl 0.1128 0.1719 0.207
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.065 0.0743 0.333
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0422 0.0276 0.047
Loa Loa (eye worm) TK/FER protein kinase 0.0524 0.0485 0.0501
Schistosoma mansoni serine/threonine protein kinase 0.1338 0.2149 0.3689
Echinococcus granulosus insulin growth factor 1 receptor beta 0.2371 0.4259 0.4192
Brugia malayi MAP kinase sur-1 0.0422 0.0276 0.0285
Loa Loa (eye worm) AGC/NDR protein kinase 0.085 0.1152 0.1189
Schistosoma mansoni tyrosine kinase 0.1812 0.3117 0.5369
Schistosoma mansoni growth factor receptor-bound protein 0.0487 0.041 0.0668
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Echinococcus multilocularis casein kinase I delta 0.0548 0.0535 0.0624
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0732 0.091 0.1082
Schistosoma mansoni serine/threonine protein kinase 0.0452 0.0339 0.0546
Onchocerca volvulus 0.0665 0.0773 0.0813
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0356 0.0143 0.0144
Schistosoma mansoni serine/threonine protein kinase 0.0681 0.0807 0.1358
Loa Loa (eye worm) TK/FER protein kinase 0.1539 0.256 0.2643
Echinococcus granulosus N chimaerin 0.048 0.0396 0.0283
Schistosoma mansoni tyrosine kinase 0.2292 0.4097 0.7071
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0531 0.05 0.058
Schistosoma mansoni protein kinase 0.1723 0.2936 0.5055
Schistosoma mansoni hypothetical protein 0.0517 0.0471 0.0776
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Plasmodium vivax serine/threonine kinase-1, putative 0.0777 0.1002 1
Toxoplasma gondii aurora kinase 0.0735 0.0917 0.3139
Brugia malayi Protein kinase domain containing protein 0.1016 0.149 0.1539
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Echinococcus multilocularis dual specificity 0.065 0.0743 0.0877
Brugia malayi Doublecortin family protein 0.0762 0.0972 0.1004
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.065 0.0743 0.3088
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0412 0.0257 0.0042
Schistosoma mansoni ephrin receptor 0.0328 0.0084 0.0104
Entamoeba histolytica protein kinase domain containing protein 0.065 0.0743 0.2034
Entamoeba histolytica casein kinase, putative 0.0548 0.0535 0.1401
Plasmodium falciparum calcium-dependent protein kinase 5 0.0509 0.0454 0.273
Plasmodium falciparum casein kinase 1 0.0548 0.0535 0.3807
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0531 0.05 0.058
Loa Loa (eye worm) hypothetical protein 0.0343 0.0116 0.012
Echinococcus multilocularis casein kinase I delta 0.0548 0.0535 0.0624
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.1451 0.2379 0.2456
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.1093 0.1649 0.1984
Trichomonas vaginalis CMGC family protein kinase 0.0452 0.0339 0.1353
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1998 0.3497 0.3421
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1172 0.1809 0.218
Giardia lamblia Kinase, CAMK CAMKL 0.0451 0.0335 0.0419
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.06 0.064 0.053
Schistosoma mansoni tyrosine kinase 0.1812 0.3117 0.5369
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Loa Loa (eye worm) CMGC/GSK protein kinase 0.065 0.0743 0.0767
Echinococcus granulosus epidermal growth factor receptor 0.3117 0.5783 0.5734
Echinococcus multilocularis nervana 2 0.0601 0.0642 0.0754
Brugia malayi Homeodomain interacting protein kinase protein 1 0.1025 0.151 0.1559
Loa Loa (eye worm) hypothetical protein 0.0604 0.0649 0.067
Trypanosoma cruzi aurora B kinase, putative 0.0735 0.0917 0.4401
Onchocerca volvulus Serine\/threonine kinase homolog 0.083 0.111 0.1209
Entamoeba histolytica protein kinase, putative 0.1494 0.2467 0.7289
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.1301 0.2072 0.2139
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Loa Loa (eye worm) hypothetical protein 0.0909 0.1273 0.1314
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Leishmania major casein kinase II, putative 0.0505 0.0446 0.1204
Schistosoma mansoni tyrosine kinase 0.1812 0.3117 0.5369
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.041 0.0253 0.0139
Echinococcus granulosus fibroblast growth factor receptor 4 0.1255 0.1979 0.1885
Brugia malayi serine/threonine-protein kinase PAK 7 0.1175 0.1815 0.1874
Echinococcus multilocularis casein kinase I alpha 0.0548 0.0535 0.0624
Entamoeba histolytica protein kinase, putative 0.0617 0.0676 0.183
Plasmodium falciparum calcium-dependent protein kinase 4 0.0509 0.0454 0.273
Brugia malayi hypothetical protein 0.0611 0.0663 0.0684
Trypanosoma cruzi casein kinase, putative 0.0548 0.0535 0.2057
Onchocerca volvulus 0.0374 0.0178 0.0117
Echinococcus granulosus protein kinase C gamma type 0.1058 0.1576 0.1477
Plasmodium falciparum calcium-dependent protein kinase 3 0.0509 0.0454 0.273
Schistosoma mansoni serine/threonine protein kinase 0.0548 0.0535 0.0886
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.1025 0.151 0.1815
Echinococcus multilocularis protein tyrosine kinase 0.2818 0.5173 0.629
Entamoeba histolytica hypothetical protein 0.0617 0.0676 0.183
Entamoeba histolytica hypothetical protein 0.193 0.3357 1
Echinococcus granulosus mitogen activated protein kinase 14 0.0805 0.1059 0.0954
Giardia lamblia Kinase, AGC AKT 0.0591 0.0622 0.2259
Brugia malayi Immunoglobulin I-set domain containing protein 0.0343 0.0116 0.012
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.065 0.0743 0.3087
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0419 0.027 0.043
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0422 0.0276 0.047
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Echinococcus multilocularis expressed conserved protein 0.068 0.0804 0.0952
Echinococcus granulosus neuroglian 0.0666 0.0775 0.0667
Trichomonas vaginalis AGC family protein kinase 0.1494 0.2467 1
Echinococcus multilocularis roundabout 2 0.0343 0.0116 0.0112
Onchocerca volvulus 0.0542 0.0522 0.052
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.1098 0.1659 0.1712
Giardia lamblia Kinase, CMGC CDK 0.06 0.064 0.2375
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.06 0.064 0.0661
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0777 0.1002 0.492
Schistosoma mansoni atypical protein kinase C 0.1507 0.2493 0.4287
Schistosoma mansoni tyrosine kinase 0.0408 0.0247 0.0386
Schistosoma mansoni tyrosine kinase 0.1608 0.27 0.4645
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1723 0.2936 0.3557
Trichomonas vaginalis CMGC family protein kinase 0.0505 0.0446 0.1789
Onchocerca volvulus 0.0524 0.0485 0.0476
Echinococcus granulosus cyclin dependent kinase 5 0.06 0.064 0.053
Brugia malayi hypothetical protein 0.0542 0.0522 0.0539
Trypanosoma brucei cdc2-related kinase 3 0.06 0.064 0.1734
Trichomonas vaginalis CAMK family protein kinase 0.1182 0.183 0.7409
Schistosoma mansoni neuroglian 0.0343 0.0116 0.0159
Mycobacterium ulcerans hypothetical protein 0.0516 0.0469 0.5
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.1277 0.2024 0.209
Loa Loa (eye worm) hypothetical protein 0.0542 0.0522 0.0539
Echinococcus granulosus phosphorylase kinase gamma subunit 0.083 0.111 0.1006
Echinococcus granulosus serine:threonine protein kinase TAO1 0.1125 0.1713 0.1616
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.3043 0.5632 0.5815
Plasmodium falciparum protein kinase, putative 0.0412 0.0257 0.0118
Schistosoma mansoni protein kinase 0.0412 0.0257 0.0404
Toxoplasma gondii CMGC kinase, CK2 family 0.0505 0.0446 0.093
Loa Loa (eye worm) SRC-1 0.1172 0.1809 0.1867
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0688 0.082 0.2684
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.1061 0.1583 0.1635
Trichomonas vaginalis AGC family protein kinase 0.0735 0.0917 0.3701
Echinococcus granulosus Immunoglobulin 0.0531 0.05 0.0389
Loa Loa (eye worm) TK/EPH protein kinase 0.0662 0.0768 0.0793
Brugia malayi SH2 domain containing protein 0.0524 0.0485 0.0501
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0617 0.0676 0.1895
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Loa Loa (eye worm) TK/FER protein kinase 0.0524 0.0485 0.0501
Echinococcus granulosus serine:threonine protein kinase 3 0.1301 0.2072 0.1979
Entamoeba histolytica protein kinase, putative 0.0509 0.0454 0.1154
Schistosoma mansoni protein kinase 0.0548 0.0535 0.0886
Onchocerca volvulus 0.0452 0.0339 0.0305
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.1691 0.287 0.2963
Echinococcus multilocularis casein kinase I gamma 0.1079 0.162 0.1949
Loa Loa (eye worm) hypothetical protein 0.0325 0.0079 0.0081
Brugia malayi Protein kinase domain containing protein 0.1723 0.2936 0.3031
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0805 0.1059 0.5269
Trichomonas vaginalis CAMK family protein kinase 0.0546 0.053 0.2131
Echinococcus multilocularis serine:threonine protein kinase N2 0.085 0.1152 0.1377
Trypanosoma brucei Casein kinase II 0.0505 0.0446 0.0856
Schistosoma mansoni serine/threonine protein kinase 0.0531 0.05 0.0825
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.1034 0.1526 0.1576
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.1539 0.256 0.3098
Schistosoma mansoni rap gtpase-activating protein 0.0542 0.0522 0.0864
Echinococcus multilocularis epidermal growth factor receptor 0.3117 0.5783 0.7037
Trichomonas vaginalis CAMK family protein kinase 0.1098 0.1659 0.6714
Echinococcus multilocularis tyrosine protein kinase shark 0.1608 0.27 0.3269
Echinococcus granulosus hypothetical protein 0.0613 0.0666 0.0557
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0509 0.0454 0.0342
Echinococcus multilocularis epidermal growth factor receptor 0.206 0.3624 0.4398
Echinococcus multilocularis N chimaerin 0.048 0.0396 0.0454
Echinococcus granulosus tyrosine protein kinase ABL1 0.1577 0.2637 0.255
Echinococcus granulosus epidermal growth factor receptor 0.206 0.3624 0.3549
Echinococcus granulosus calcium activated potassium channel 0.0681 0.0807 0.0699
Loa Loa (eye worm) AGC/PKN protein kinase 0.1509 0.2497 0.2578
Brugia malayi Protein kinase domain containing protein 0.1787 0.3065 0.3165
Brugia malayi protein-tyrosine kinase 0.097 0.1397 0.1443
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.1182 0.183 0.1889
Trichomonas vaginalis CMGC family protein kinase 0.065 0.0743 0.2993
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.1125 0.1713 0.1769
Trichomonas vaginalis AGC family protein kinase 0.1494 0.2467 1
Echinococcus multilocularis insulin receptor 0.2292 0.4097 0.4976
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0367 0.0164 0.0171
Brugia malayi Protein kinase domain containing protein 0.085 0.1152 0.1189
Entamoeba histolytica protein kinase domain containing protein 0.0617 0.0676 0.183
Schistosoma mansoni tyrosine kinase 0.3117 0.5783 1
Echinococcus multilocularis calcium activated potassium channel 0.0681 0.0807 0.0956
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0725 0.0896 0.1513
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0509 0.0454 0.0525
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0617 0.0676 0.2921
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.3043 0.5632 0.5815
Schistosoma mansoni serine/threonine protein kinase 0.1787 0.3065 0.528
Echinococcus granulosus tyrosine protein kinase Lyn 0.1336 0.2144 0.2052
Schistosoma mansoni protein kinase 0.0735 0.0917 0.155
Brugia malayi Protein kinase domain containing protein 0.1098 0.1659 0.1712
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0433 0.03 0.0337
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Trichomonas vaginalis CMGC family protein kinase 0.0422 0.0276 0.1099
Trichomonas vaginalis CMGC family protein kinase 0.0505 0.0446 0.1789
Echinococcus granulosus dual specificity 0.0617 0.0676 0.0567
Trypanosoma cruzi polo-like protein kinase, putative 0.1182 0.183 1
Schistosoma mansoni serine/threonine protein kinase 0.0451 0.0335 0.0539
Schistosoma mansoni serine/threonine protein kinase 0.1263 0.1995 0.3421
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0509 0.0454 0.0469
Brugia malayi probable protein kinase 0.1317 0.2105 0.2173
Loa Loa (eye worm) hypothetical protein 0.0705 0.0854 0.0882
Echinococcus multilocularis cyclin dependent kinase 0.06 0.064 0.0752
Echinococcus multilocularis 0.0882 0.1216 0.1456
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Loa Loa (eye worm) casein kinase 0.0915 0.1285 0.1326
Trichomonas vaginalis CAMK family protein kinase 0.1182 0.183 0.7409
Entamoeba histolytica casein kinase, putative 0.0505 0.0446 0.1131
Entamoeba histolytica protein kinase domain containing protein 0.065 0.0743 0.2034
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0735 0.0917 0.2565
Brugia malayi Variant SH3 domain containing protein 0.0477 0.0389 0.0401
Loa Loa (eye worm) hypothetical protein 0.0665 0.0773 0.0798
Loa Loa (eye worm) CMGC/MAPK/NMO protein kinase 0.0471 0.0376 0.0388
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0422 0.0276 0.047
Echinococcus multilocularis dual specificity 0.065 0.0743 0.0877
Loa Loa (eye worm) hypothetical protein 0.0436 0.0305 0.0315
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0477 0.0389 0.0632
Schistosoma mansoni serine/threonine protein kinase 0.1647 0.2781 0.4786
Trichomonas vaginalis CAMK family protein kinase 0.0576 0.0592 0.2379
Entamoeba histolytica PH domain containing protein kinase, putative 0.0574 0.0588 0.1563
Loa Loa (eye worm) TK/ABL protein kinase 0.1577 0.2637 0.2722
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0548 0.0535 0.0552
Giardia lamblia Aurora kinase 0.0735 0.0917 0.4149
Echinococcus granulosus casein kinase I delta 0.0548 0.0535 0.0424
Schistosoma mansoni serine/threonine protein kinase 0.0451 0.0335 0.0539
Entamoeba histolytica SH2-protein kinase domain containing protein 0.044 0.0313 0.0724
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.065 0.0743 0.0767
Entamoeba histolytica p21-activated kinase 0.0477 0.0389 0.0955
Trichomonas vaginalis CMGC family protein kinase 0.0452 0.0339 0.1353
Echinococcus granulosus tyrosine protein kinase Fyn 0.1172 0.1809 0.1713
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0531 0.05 0.0516
Trypanosoma cruzi Protein kinase B 0.0808 0.1065 0.5311
Trichomonas vaginalis CMGC family protein kinase 0.0422 0.0276 0.1099
Brugia malayi hypothetical protein 0.1125 0.1713 0.1769
Echinococcus granulosus tyrosine protein kinase shark 0.1608 0.27 0.2614
Loa Loa (eye worm) hypothetical protein 0.0611 0.0663 0.0684
Echinococcus multilocularis nervana 2 0.0601 0.0642 0.0754
Trichomonas vaginalis AGC family protein kinase 0.0688 0.082 0.3308
Schistosoma mansoni tyrosine kinase 0.1888 0.3273 0.5641
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0735 0.0917 0.2565
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0427 0.0286 0.0643
Echinococcus granulosus Protein kinase C brain isozyme 0.1263 0.1995 0.1901
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0419 0.027 0.0082
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1172 0.1809 0.218
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Plasmodium vivax casein kinase 1, putative 0.0548 0.0535 0.4946
Brugia malayi Tyrosine-protein kinase abl-1 0.065 0.0743 0.0768
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0427 0.0286 0.0529
Onchocerca volvulus 0.0705 0.0854 0.0909
Trypanosoma brucei cdc2-related kinase 1 0.06 0.064 0.1734
Schistosoma mansoni protein kinase 0.22 0.3909 0.6746
Entamoeba histolytica protein kinase, putative 0.0356 0.0143 0.0206
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1998 0.3497 0.3611
Trypanosoma cruzi casein kinase, putative 0.0548 0.0535 0.2057
Brugia malayi Hr1 repeat family protein 0.1509 0.2497 0.2578
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0509 0.0454 0.0966
Echinococcus granulosus serine:threonine protein kinase mig 15 0.1152 0.1769 0.1673
Onchocerca volvulus 0.0378 0.0187 0.0127
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.094 0.1335 0.1234
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.1125 0.1713 0.2063
Brugia malayi Immunoglobulin I-set domain containing protein 0.0343 0.0116 0.012
Entamoeba histolytica protein kinase domain containing protein 0.0412 0.0257 0.0554
Trichomonas vaginalis AGC family protein kinase 0.0531 0.05 0.2005
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.1691 0.287 0.2963
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0531 0.05 0.058
Schistosoma mansoni nephrin 0.0343 0.0116 0.0159
Schistosoma mansoni protein kinase 0.0323 0.0075 0.0088
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.041 0.0253 0.0279
Onchocerca volvulus 0.0524 0.0485 0.0476
Entamoeba histolytica protein kinase, putative 0.1494 0.2467 0.7289
Loa Loa (eye worm) CAMK/PKD protein kinase 0.1034 0.1526 0.1576
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0774 0.0996 0.1029
Echinococcus multilocularis rho associated protein kinase 0.1647 0.2781 0.3368
Schistosoma mansoni protein kinase 0.1048 0.1556 0.266
Brugia malayi Immunoglobulin I-set domain containing protein 0.1389 0.2254 0.2327
Brugia malayi Protein kinase domain containing protein 0.0452 0.0339 0.035
Schistosoma mansoni serine/threonine protein kinase 0.085 0.1152 0.1957
Echinococcus multilocularis cyclin dependent kinase 5 0.06 0.064 0.0752
Echinococcus multilocularis tyrosine protein kinase HCK 0.0695 0.0834 0.0989
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0507 0.0451 0.0466
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.1093 0.1649 0.1984
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0765 0.0977 0.0871
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0378 0.0187 0.0193
Trypanosoma brucei protein kinase, putative 0.065 0.0743 0.2197
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0343 0.0116 0.0112
Loa Loa (eye worm) CAMK/PHK protein kinase 0.083 0.111 0.1146
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Brugia malayi Protein kinase domain containing protein 0.2292 0.4097 0.423
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0383 0.0197 0.0082
Echinococcus granulosus tyrosine protein kinase Src42A 0.1172 0.1809 0.1713
Leishmania major protein kinase A catalytic subunit isoform 2 0.0531 0.05 0.1542
Loa Loa (eye worm) hypothetical protein 0.0611 0.0663 0.0684
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0343 0.0116 0.012
Echinococcus multilocularis activin receptor type 0.0412 0.0257 0.0284
Trichomonas vaginalis AGC family protein kinase 0.1019 0.1497 0.6056
Loa Loa (eye worm) AUR protein kinase 0.0735 0.0917 0.0947
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.1157 0.1779 0.2144
Onchocerca volvulus 0.0524 0.0485 0.0476
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.22 0.3909 0.3838
Echinococcus granulosus tyrosine protein kinase 0.1466 0.2409 0.232
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.065 0.0743 0.0877
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.1172 0.1809 0.1713
Trichomonas vaginalis STE family protein kinase 0.0433 0.03 0.1195
Onchocerca volvulus 0.087 0.1191 0.1304
Brugia malayi Immunoglobulin I-set domain containing protein 0.0611 0.0663 0.0684
Loa Loa (eye worm) hypothetical protein 0.0531 0.05 0.0516
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0581 0.0602 0.0491
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1998 0.3497 0.4243
Onchocerca volvulus 0.065 0.0743 0.0778
Echinococcus granulosus NCK adaptor protein 0.0477 0.0389 0.0276
Trichomonas vaginalis STE family protein kinase 0.0323 0.0075 0.0281
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.041 0.0253 0.0261
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0433 0.03 0.0337
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.065 0.0743 0.3331
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.1787 0.3065 0.35
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0422 0.0276 0.0123
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0477 0.0389 0.0401
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0765 0.0977 0.9671
Trichomonas vaginalis CMGC family protein kinase 0.065 0.0743 0.2993
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0777 0.1002 0.3369
Schistosoma mansoni cell adhesion molecule 0.0343 0.0116 0.0159
Plasmodium vivax tyrosine kinase-like protein, putative 0.0408 0.0248 0.184
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0524 0.0485 0.1248
Trichomonas vaginalis CAMK family protein kinase 0.1182 0.183 0.7409
Echinococcus granulosus titin 0.0378 0.0187 0.0072
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.065 0.0743 0.2197
Schistosoma mansoni ephrin receptor 0.0573 0.0586 0.0975
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.1182 0.183 1
Brugia malayi Variant SH3 domain containing protein 0.0477 0.0389 0.0401
Onchocerca volvulus 0.0548 0.0535 0.0535
Leishmania major protein kinase, putative 0.0427 0.0286 0.0184
Giardia lamblia Kinase, NEK 0.0688 0.082 0.3528
Echinococcus multilocularis mitogen activated protein kinase 11 0.0805 0.1059 0.1263
Brugia malayi Protein kinase domain 0.0433 0.03 0.031
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0777 0.1002 0.492
Trichomonas vaginalis CMGC family protein kinase 0.06 0.064 0.2577
Echinococcus granulosus Glutaredoxin protein 5 0.0601 0.0642 0.0532
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0422 0.0276 0.0088
Loa Loa (eye worm) TK protein kinase 0.0695 0.0834 0.0861
Schistosoma mansoni serine/threonine protein kinase 0.0777 0.1002 0.1696
Brugia malayi casein kinase I 0.0548 0.0535 0.0552
Schistosoma mansoni vav2 0.0524 0.0485 0.0799
Trichomonas vaginalis CMGC family protein kinase 0.0422 0.0276 0.1099
Schistosoma mansoni hypothetical protein 0.0517 0.0471 0.0776
Echinococcus multilocularis ephrin type A receptor 4 A 0.0573 0.0586 0.0686
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0634 0.0711 0.2886
Schistosoma mansoni serine/threonine protein kinase 0.0617 0.0676 0.1131
Echinococcus granulosus casein kinase I delta 0.0548 0.0535 0.0424
Echinococcus multilocularis casein kinase ii subunit alpha 0.0505 0.0446 0.0515
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0325 0.0079 0.0082
Loa Loa (eye worm) TK/INSR protein kinase 0.2292 0.4097 0.423
Echinococcus granulosus cGMP dependent protein kinase 1 0.068 0.0804 0.0696
Echinococcus multilocularis c src tyrosine kinase 0.0725 0.0896 0.1065
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0531 0.05 0.1839
Onchocerca volvulus 0.0524 0.0485 0.0476
Trichomonas vaginalis CMGC family protein kinase 0.0505 0.0446 0.1789
Loa Loa (eye worm) hypothetical protein 0.1152 0.1769 0.1827
Schistosoma mansoni serine/threonine protein kinase 0.1016 0.149 0.2545
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0762 0.0972 0.1004
Loa Loa (eye worm) hypothetical protein 0.0661 0.0764 0.0789
Loa Loa (eye worm) CAMK protein kinase 0.0378 0.0187 0.0193
Schistosoma mansoni serine/threonine protein kinase 0.0531 0.05 0.0825
Trichomonas vaginalis AGC family protein kinase 0.0976 0.1408 0.5696
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0509 0.0454 0.4068
Echinococcus granulosus tyrosine protein kinase Blk 0.097 0.1397 0.1296
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0829 0.1108 0.1144
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.1016 0.149 0.1791
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0419 0.027 0.0102
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0732 0.091 0.0804
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0343 0.0116 0.0159
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.085 0.1152 0.1048
Echinococcus granulosus casein kinase ii subunit alpha 0.0505 0.0446 0.0334
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Loa Loa (eye worm) hypothetical protein 0.0542 0.0522 0.0539
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.094 0.1335 0.1378
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.206 0.3624 0.3549
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.065 0.0743 0.1247
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Brugia malayi ephrin receptor 1 precursor 0.0401 0.0235 0.0242
Echinococcus multilocularis protein kinase c iota type 0.1476 0.243 0.2939
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0433 0.03 0.0186
Schistosoma mansoni titin 0.0378 0.0187 0.0282
Brugia malayi Protein kinase domain containing protein 0.0524 0.0485 0.0501
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0542 0.0522 0.198
Loa Loa (eye worm) TK/FER protein kinase 0.0524 0.0485 0.0501
Entamoeba histolytica cell division protein kinase 2, putative 0.06 0.064 0.1722
Echinococcus multilocularis NCK adaptor protein 0.0487 0.041 0.047
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.048 0.0396 0.0645
Loa Loa (eye worm) TK/FER protein kinase 0.0524 0.0485 0.0501
Loa Loa (eye worm) hypothetical protein 0.1291 0.2052 0.2119
Plasmodium falciparum calcium-dependent protein kinase 1 0.0509 0.0454 0.273
Plasmodium falciparum glycogen synthase kinase 3 0.065 0.0743 0.6562
Schistosoma mansoni serine/threonine protein kinase 0.1061 0.1583 0.2707
Schistosoma mansoni protein kinase 0.1317 0.2105 0.3612
Loa Loa (eye worm) TK/FER protein kinase 0.0524 0.0485 0.0501
Brugia malayi Temporarily assigned gene name protein 59 0.0655 0.0753 0.0777
Schistosoma mansoni serine/threonine-protein kinase 0.0808 0.1065 0.1807
Brugia malayi intracellular kinase 0.065 0.0743 0.0767
Onchocerca volvulus 0.0452 0.0339 0.0305
Brugia malayi serine/threonine protein kinase 6 0.0735 0.0917 0.0947
Schistosoma mansoni tyrosine kinase 0.0725 0.0896 0.1513
Giardia lamblia Kinase, CMGC DYRK 0.065 0.0743 0.3031
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0509 0.0454 0.0966
Echinococcus granulosus tyrosine protein kinase Src64B 0.1172 0.1809 0.1713
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0433 0.03 0.0186
Loa Loa (eye worm) hypothetical protein 0.0611 0.0663 0.0684
Trichomonas vaginalis STE family protein kinase 0.0688 0.082 0.3308
Loa Loa (eye worm) hypothetical protein 0.0406 0.0244 0.0252
Echinococcus granulosus tyrosine kinase 0.097 0.1397 0.1296
Schistosoma mansoni serine/threonine protein kinase 0.1157 0.1779 0.3047
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.1182 0.183 0.2205
Echinococcus multilocularis fibroblast growth factor receptor 4 0.1255 0.1979 0.2387
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0805 0.1059 0.3626
Giardia lamblia Kinase, PLK 0.1182 0.183 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0601 0.0642 0.0754
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0356 0.0143 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Brugia malayi cell division control protein 2 homolog 0.06 0.064 0.0661
Brugia malayi Protein kinase domain containing protein 0.0576 0.0592 0.0611
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0765 0.0977 0.4768
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0706 0.0858 0.1018
Echinococcus granulosus activin receptor type 0.0412 0.0257 0.0143
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0777 0.1002 0.3369
Echinococcus multilocularis PAK box P21 Rho binding 0.0323 0.0075 0.0062
Echinococcus granulosus serine threonine protein kinase nrc 0.0765 0.0977 0.0871
Echinococcus multilocularis cyclin dependent kinase 1 0.06 0.064 0.0752
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0471 0.0376 0.0429
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0531 0.05 0.0388
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.1787 0.3065 0.3715
Echinococcus multilocularis tyrosine kinase 0.0524 0.0485 0.0562
Entamoeba histolytica protein kinase, putative 0.0735 0.0917 0.2565
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.1277 0.2024 0.1931
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0735 0.0917 0.9084
Echinococcus granulosus nervana 2 0.0601 0.0642 0.0532
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0805 0.1059 0.5269
Echinococcus granulosus tyrosine protein kinase Srms 0.2594 0.4714 0.4652
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0777 0.1002 0.3536
Brugia malayi Protein kinase domain containing protein 0.041 0.0253 0.0261
Brugia malayi RhoGAP domain containing protein 0.048 0.0396 0.0409
Schistosoma mansoni serine/threonine protein kinase 0.0453 0.034 0.0548
Schistosoma mansoni serine/threonine protein kinase 0.1093 0.1649 0.282
Loa Loa (eye worm) TK/EGFR protein kinase 0.3117 0.5783 0.5971
Echinococcus granulosus tyrosine protein kinase Fps85D 0.1539 0.256 0.2472
Echinococcus granulosus cGMP dependent protein kinase 0.068 0.0804 0.0696
Schistosoma mansoni serine/threonine protein kinase 0.0422 0.0276 0.0437
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.1338 0.2149 0.2219
Echinococcus multilocularis tyrosine protein kinase Fyn 0.097 0.1397 0.1677
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.1025 0.151 0.1559
Entamoeba histolytica protein kinase, putative 0.0515 0.0467 0.1194
Schistosoma mansoni serine/threonine protein kinase 0.0451 0.0335 0.0539
Trichomonas vaginalis CK1 family protein kinase 0.0548 0.0535 0.2149
Brugia malayi Fes/CIP4 homology domain containing protein 0.0587 0.0613 0.0633
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.22 0.3909 0.4747
Brugia malayi Protein kinase domain containing protein 0.1466 0.2409 0.2487
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Echinococcus multilocularis serine:threonine protein kinase N2 0.1509 0.2497 0.3021
Schistosoma mansoni serine/threonine protein kinase 0.2418 0.4356 0.7521
Schistosoma mansoni tyrosine kinase 0.206 0.3624 0.625
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.085 0.1152 0.1377
Echinococcus multilocularis cyclin dependent kinase 1 0.06 0.064 0.0752
Plasmodium falciparum serine/threonine protein kinase, putative 0.0735 0.0917 0.8877
Trichomonas vaginalis AGC family protein kinase 0.1494 0.2467 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0477 0.0389 0.0445
Loa Loa (eye worm) hypothetical protein 0.0533 0.0503 0.0519
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Loa Loa (eye worm) hypothetical protein 0.0477 0.0389 0.0401
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0356 0.0143 0.0027
Echinococcus granulosus CDC7 cell division cycle 7 0.0452 0.0339 0.0226
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.068 0.0804 0.2609
Brugia malayi Protein kinase domain containing protein 0.4779 0.918 0.9477
Plasmodium falciparum serine/threonine protein kinase KIN 0.0451 0.0335 0.1155
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0451 0.0335 0.0497
Plasmodium falciparum NIMA related kinase 1 0.0688 0.082 0.7591
Loa Loa (eye worm) hypothetical protein 0.0517 0.0471 0.0487
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0505 0.0446 0.3986
Schistosoma mansoni adapter molecule crk 0.0477 0.0389 0.0632
Entamoeba histolytica casein kinase 1, putative 0.0548 0.0535 0.1401
Echinococcus granulosus protein kinase c epsilon type 0.1061 0.1583 0.1485
Loa Loa (eye worm) TK protein kinase 0.1264 0.1997 0.2061
Onchocerca volvulus 0.0913 0.128 0.1408
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.1172 0.1809 0.218
Giardia lamblia Kinase, CK1 Casein kinase 0.0548 0.0535 0.17
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.06 0.064 0.2437
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0477 0.0389 0.0401
Giardia lamblia Kinase, STE STE20 0.0433 0.03 0.0194
Giardia lamblia Kinase, CMGC CK2 0.0505 0.0446 0.1131
Echinococcus multilocularis cGMP dependent protein kinase 1 0.068 0.0804 0.0952
Echinococcus multilocularis casein kinase I alpha 0.0548 0.0535 0.0624
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0777 0.1002 0.1034
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Leishmania major protein kinase A catalytic subunit 0.0531 0.05 0.1542
Onchocerca volvulus 0.0524 0.0485 0.0476
Echinococcus granulosus ephrin type A receptor 4 A 0.0573 0.0586 0.0476
Echinococcus multilocularis serine:threonine protein kinase 0.0576 0.0592 0.0693
Plasmodium falciparum calcium-dependent protein kinase 2 0.0509 0.0454 0.273
Echinococcus multilocularis dual specificity protein kinase clk2 0.0777 0.1002 0.1194
Schistosoma mansoni serine/threonine protein kinase 0.0356 0.0143 0.0205
Trichomonas vaginalis CAMK family protein kinase 0.1182 0.183 0.7409
Brugia malayi Protein kinase domain containing protein 0.0524 0.0485 0.0501
Entamoeba histolytica protein kinase, putative 0.065 0.0743 0.2034
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0531 0.05 0.0826
Echinococcus granulosus protein kinase c iota type 0.1476 0.243 0.2342
Entamoeba histolytica protein kinase, putative 0.085 0.1152 0.328
Echinococcus multilocularis neuroglian 0.0666 0.0775 0.0917
Trichomonas vaginalis CMGC family protein kinase 0.065 0.0743 0.2993
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0427 0.0286 0.0529
Trypanosoma brucei polo-like protein kinase 0.1182 0.183 0.7114
Loa Loa (eye worm) TK protein kinase 0.1389 0.2254 0.2327
Leishmania major protein kinase A catalytic subunit isoform 1 0.0531 0.05 0.1542
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0805 0.1059 0.1093
Loa Loa (eye worm) TK/ALK protein kinase 0.0967 0.1389 0.1434
Schistosoma mansoni serine/threonine protein kinase 0.1509 0.2497 0.4293
Schistosoma mansoni tyrosine kinase 0.206 0.3624 0.625
Echinococcus multilocularis protein kinase shaggy 0.065 0.0743 0.0877
Trichomonas vaginalis CMGC family protein kinase 0.065 0.0743 0.2993
Echinococcus granulosus nervana 2 0.0601 0.0642 0.0532
Schistosoma mansoni protein kinase 0.0505 0.0446 0.0732
Echinococcus granulosus tyrosine protein kinase Fyn 0.1172 0.1809 0.1713
Plasmodium vivax unspecified product 0.0505 0.0446 0.3986
Echinococcus granulosus dual specificity 0.065 0.0743 0.0634
Entamoeba histolytica protein kinase, putative 0.044 0.0313 0.0724
Echinococcus granulosus dual specificity 0.065 0.0743 0.0634
Giardia lamblia Kinase, NEK 0.0688 0.082 0.3528
Trichomonas vaginalis CMGC family protein kinase 0.065 0.0743 0.2993
Brugia malayi Casein kinase II, alpha chain 0.0505 0.0446 0.0461
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.083 0.111 0.1326
Loa Loa (eye worm) AGC/PKG protein kinase 0.068 0.0804 0.083
Brugia malayi Protein kinase domain containing protein 0.0777 0.1002 0.1034
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0509 0.0454 0.0469
Trichomonas vaginalis CAMK family protein kinase 0.0546 0.053 0.2131
Echinococcus granulosus serine:threonine protein kinase N2 0.0658 0.076 0.0651
Trichomonas vaginalis CMGC family protein kinase 0.06 0.064 0.2577
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0343 0.0116 0.0112
Trypanosoma brucei rac serine-threonine kinase, putative 0.1494 0.2467 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0765 0.0977 0.1163
Echinococcus granulosus serine:threonine protein kinase 0.0576 0.0592 0.0481
Trichomonas vaginalis CMGC family protein kinase 0.0505 0.0446 0.1789
Loa Loa (eye worm) hypothetical protein 0.0795 0.1039 0.1073
Schistosoma mansoni serine/threonine protein kinase 0.1025 0.151 0.2579
Echinococcus multilocularis roundabout 2 0.0875 0.1202 0.1438
Loa Loa (eye worm) thyroid receptor interactor 0.0587 0.0613 0.0633
Giardia lamblia Kinase, CMGC CLK 0.0777 0.1002 0.4692
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0581 0.0602 0.0705
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0735 0.0917 0.109
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.041 0.0253 0.0261
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0821 0.1091 0.1127
Trypanosoma brucei casein kinase I, isoform 2 0.0548 0.0535 0.1257
Giardia lamblia Kinase, AGC PKA 0.0765 0.0977 0.4532
Echinococcus granulosus serine:threonine protein kinase 0.0576 0.0592 0.0481
Echinococcus granulosus protein kinase shaggy 0.065 0.0743 0.0634
Trichomonas vaginalis CMGC family protein kinase 0.065 0.0743 0.2993
Giardia lamblia Kinase, AGC PKA 0.0531 0.05 0.1472
Loa Loa (eye worm) hypothetical protein 0.0451 0.0335 0.0346
Echinococcus multilocularis serine threonine protein kinase 0.1058 0.1576 0.1896
Schistosoma mansoni serine/threonine protein kinase 0.1181 0.1828 0.3131
Echinococcus multilocularis Immunoglobulin 0.0531 0.05 0.0581
Brugia malayi Cam kinase protein 1 0.0509 0.0454 0.0469
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0531 0.05 0.058
Schistosoma mansoni serine/threonine protein kinase 0.0451 0.0335 0.0539
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.06 0.064 0.184
Echinococcus granulosus tyrosine kinase 0.0524 0.0485 0.0373
Schistosoma mansoni protein kinase 0.0433 0.03 0.0478
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0531 0.05 0.0826
Trichomonas vaginalis CMGC family protein kinase 0.0777 0.1002 0.4045
Trypanosoma cruzi casein kinase II, putative 0.0505 0.0446 0.1513
Echinococcus granulosus mitogen activated protein kinase 11 0.0805 0.1059 0.0954
Brugia malayi Protein kinase domain containing protein 0.0419 0.027 0.0279
Brugia malayi Protein kinase domain containing protein 0.0973 0.1402 0.1448
Brugia malayi Protein kinase c protein 2 0.0577 0.0593 0.0612
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0601 0.0642 0.0532
Schistosoma mansoni serine/threonine protein kinase 0.065 0.0743 0.1247
Echinococcus granulosus cyclin dependent kinase 0.06 0.064 0.053
Leishmania major casein kinase, putative 0.0548 0.0535 0.1768
Echinococcus granulosus serine:threonine protein kinase PLK1 0.1182 0.183 0.1734
Entamoeba histolytica protein kinase, putative 0.041 0.0253 0.0542
Schistosoma mansoni cell adhesion molecule 0.0343 0.0116 0.0159
Loa Loa (eye worm) hypothetical protein 0.0576 0.0592 0.0611
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0542 0.0522 0.1201
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.1172 0.1809 0.218
Loa Loa (eye worm) RhoGAP domain-containing protein 0.048 0.0396 0.0409
Echinococcus multilocularis tyrosine protein kinase Src64B 0.1172 0.1809 0.218
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0531 0.05 0.1097
Trypanosoma cruzi casein kinase, putative 0.0548 0.0535 0.2057
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0808 0.1065 0.5311
Trypanosoma cruzi cdc2-related kinase 1 0.06 0.064 0.2703
Brugia malayi Protein kinase domain containing protein 0.2849 0.5235 0.5405
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0777 0.1002 0.492
Echinococcus granulosus casein kinase I alpha 0.0548 0.0535 0.0424
Schistosoma mansoni ste20-related kinase 0.1038 0.1536 0.2624
Brugia malayi protein kinase C II. 0.1061 0.1583 0.1635
Loa Loa (eye worm) TK/FER protein kinase 0.0524 0.0485 0.0501
Schistosoma mansoni tyrosine kinase 0.1172 0.1809 0.3098
Trichomonas vaginalis CAMK family protein kinase 0.1182 0.183 0.7409
Echinococcus multilocularis mitogen activated protein kinase 11 0.0805 0.1059 0.1263
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1172 0.1809 0.218
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0576 0.0592 0.0611
Schistosoma mansoni tyrosine kinase 0.0512 0.0461 0.0757
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0422 0.0276 0.0133
Schistosoma mansoni hypothetical protein 0.0542 0.0522 0.0864
Trichomonas vaginalis CAMK family protein kinase 0.0509 0.0454 0.182
Echinococcus multilocularis Glutaredoxin protein 5 0.0601 0.0642 0.0754
Schistosoma mansoni tyrosine kinase 0.0725 0.0896 0.1513
Brugia malayi Furin-like cysteine rich region family protein 0.3117 0.5783 0.5971
Schistosoma mansoni serine/threonine protein kinase 0.1182 0.183 0.3134
Giardia lamblia Kinase, CMGC MAPK 0.0422 0.0276 0.0042
Brugia malayi casein kinase 1, delta 0.0548 0.0535 0.0552
Brugia malayi protein unc-22 0.0378 0.0187 0.0193
Echinococcus multilocularis mitogen activated protein kinase 14 0.0805 0.1059 0.1263
Echinococcus granulosus twitchin 0.083 0.111 0.1006
Schistosoma mansoni tyrosine kinase 0.1301 0.2074 0.3558
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.048 0.0396 0.0454
Echinococcus multilocularis protein kinase c epsilon type 0.1061 0.1583 0.1905
Onchocerca volvulus 0.4118 0.7829 0.9083
Echinococcus granulosus casein kinase I alpha 0.0548 0.0535 0.0424
Entamoeba histolytica protein kinase, putative 0.0433 0.03 0.0685
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0542 0.0522 0.198
Loa Loa (eye worm) hypothetical protein 0.0795 0.1039 0.1073
Toxoplasma gondii AGC kinase 0.1451 0.2379 1
Trichomonas vaginalis AGC family protein kinase 0.085 0.1152 0.4655
Giardia lamblia Kinase, CDC7 0.0452 0.0339 0.0443
Schistosoma mansoni serine/threonine protein kinase 0.0735 0.0917 0.155
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.1787 0.3065 0.2984
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.1277 0.2024 0.2443
Brugia malayi Protein kinase domain containing protein 0.0471 0.0376 0.0388
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0531 0.05 0.1097
Toxoplasma gondii casein kinase I 0.0548 0.0535 0.1346
Echinococcus multilocularis death associated protein kinase 1 0.4304 0.8209 1
Schistosoma mansoni serine/threonine kinase 0.085 0.1152 0.1957
Echinococcus multilocularis 0.0774 0.0996 0.1187
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0805 0.1059 0.5097
Echinococcus granulosus casein kinase I alpha 0.0548 0.0535 0.0424
Brugia malayi Temporarily assigned gene name protein 59 0.0542 0.0522 0.0539
Echinococcus granulosus rho-associated protein kinase 1 0.1647 0.2781 0.2696
Entamoeba histolytica protein kinase, putative 0.0735 0.0917 0.2565
Loa Loa (eye worm) hypothetical protein 0.2343 0.4201 0.4337
Schistosoma mansoni tyrosine kinase 0.1255 0.1979 0.3393
Echinococcus multilocularis casein kinase i 0.0548 0.0535 0.0624
Schistosoma mansoni serine/threonine protein kinase 0.06 0.064 0.1069
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0706 0.0858 0.075
Leishmania major protein kinase, putative 0.0509 0.0454 0.1252
Trichomonas vaginalis CK1 family protein kinase 0.0548 0.0535 0.2149
Schistosoma mansoni serine/threonine protein kinase 0.068 0.0804 0.1353
Echinococcus multilocularis mitogen activated protein kinase 14 0.0805 0.1059 0.1263
Giardia lamblia Kinase, CMGC CDK 0.06 0.064 0.2375
Loa Loa (eye worm) AUR protein kinase 0.0735 0.0917 0.0947
Loa Loa (eye worm) TK/FER protein kinase 0.0524 0.0485 0.0501
Echinococcus granulosus homeodomain interacting protein kinase 3 0.1025 0.151 0.141
Loa Loa (eye worm) hypothetical protein 0.0531 0.05 0.0516
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0451 0.0335 0.0379
Trichomonas vaginalis AGC family protein kinase 0.041 0.0253 0.1004
Brugia malayi map kinase activated protein kinase protein 2 0.1998 0.3497 0.3611
Brugia malayi serine/threonine-protein kinase 6 0.0735 0.0917 0.0947
Loa Loa (eye worm) hypothetical protein 0.0524 0.0485 0.0501
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0661 0.0764 0.0656
Loa Loa (eye worm) CMGC/GSK protein kinase 0.065 0.0743 0.0767
Echinococcus multilocularis dual specificity testis specific protein kinase 0.1048 0.1556 0.1872
Schistosoma mansoni cell adhesion molecule 0.074 0.0927 0.1566
Brugia malayi Protein kinase domain containing protein 0.0976 0.1408 0.1454
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1787 0.3065 0.3165
Schistosoma mansoni growth factor receptor-bound protein 0.0477 0.0389 0.0632
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0333 0.0095 0.036
Echinococcus granulosus casein kinase i 0.0548 0.0535 0.0424
Brugia malayi Immunoglobulin I-set domain containing protein 0.0343 0.0116 0.012
Loa Loa (eye worm) AGC/AKT protein kinase 0.1494 0.2467 0.2547
Echinococcus granulosus titin 0.0378 0.0187 0.0072
Trichomonas vaginalis STE family protein kinase 0.0433 0.03 0.1195
Loa Loa (eye worm) hypothetical protein 0.0913 0.128 0.1321
Trypanosoma brucei aurora B kinase 0.0735 0.0917 0.2986
Echinococcus granulosus NDR protein kinase 0.085 0.1152 0.1048
Entamoeba histolytica protein kinase, putative 0.0617 0.0676 0.183
Schistosoma mansoni serine/threonine kinase 0.1098 0.1659 0.2837
Plasmodium falciparum cGMP-dependent protein kinase 0.068 0.0804 0.7378
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0412 0.0257 0.0351
Entamoeba histolytica serine/threonine protein kinase, putative 0.0451 0.0335 0.0793
Schistosoma mansoni protein kinase 0.1048 0.1556 0.266
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0343 0.0116 0.0112
Onchocerca volvulus 0.1483 0.2445 0.2774
Brugia malayi serine/threonine kinase 12 0.0735 0.0917 0.0947
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.1175 0.1815 0.1874
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0451 0.0335 0.2782
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0451 0.0335 0.0831
Trichomonas vaginalis CAMK family protein kinase 0.1182 0.183 0.7409
Echinococcus multilocularis mitogen activated protein kinase 3 0.0422 0.0276 0.0308
Echinococcus multilocularis mitogen activated protein kinase 0.0422 0.0276 0.0308
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.06 0.064 0.2437
Echinococcus granulosus protein tyrosine kinase 0.2818 0.5173 0.5116
Loa Loa (eye worm) hypothetical protein 0.087 0.1191 0.123
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0422 0.0276 0.0285
Loa Loa (eye worm) hypothetical protein 0.0651 0.0745 0.0769
Brugia malayi SRC-1 0.1172 0.1809 0.1867
Schistosoma mansoni protein kinase 0.0976 0.1408 0.2402
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0509 0.0454 0.0469
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.06 0.064 0.0661
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0412 0.0257 0.0351
Echinococcus granulosus dual specificity testis-specific protein kinase 0.1048 0.1556 0.1457
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0777 0.1002 0.492
Echinococcus granulosus raf serine:threonine protein kinase 0.0453 0.034 0.0227
Trichomonas vaginalis STE family protein kinase 0.0433 0.03 0.1195
Echinococcus granulosus glycogen synthase kinase 3 beta 0.065 0.0743 0.0634
Plasmodium falciparum casein kinase 2, alpha subunit 0.0505 0.0446 0.263
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0509 0.0454 0.0891
Brugia malayi Protein kinase domain containing protein 0.2274 0.4061 0.4193
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0617 0.0676 0.0698
Brugia malayi Protein kinase domain containing protein 0.0967 0.139 0.1435
Loa Loa (eye worm) hypothetical protein 0.1217 0.1902 0.1963
Trypanosoma cruzi cdc2-related kinase 1 0.06 0.064 0.2703
Trichomonas vaginalis CMGC family protein kinase 0.065 0.0743 0.2993
Entamoeba histolytica protein kinase, putative 0.065 0.0743 0.2034
Echinococcus granulosus defective proboscis extension response 0.0531 0.05 0.0389
Brugia malayi Protein kinase domain containing protein 0.0524 0.0485 0.0501
Schistosoma mansoni serine/threonine protein kinase 0.041 0.0253 0.0397
Loa Loa (eye worm) TK protein kinase 0.1466 0.2409 0.2487
Schistosoma mansoni serine/threonine protein kinase 0.085 0.1152 0.1957
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.1016 0.149 0.1539
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0531 0.05 0.1097
Giardia lamblia Kinase, CMGC GSK 0.065 0.0743 0.3031
Loa Loa (eye worm) AUR protein kinase 0.0735 0.0917 0.0947
Schistosoma mansoni protein kinase 0.0433 0.03 0.0478
Entamoeba histolytica protein kinase domain containing protein 0.1025 0.151 0.4371
Echinococcus multilocularis Protein kinase C, brain isozyme 0.1263 0.1995 0.2407
Leishmania major protein kinase, putative 0.0777 0.1002 0.4735
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Onchocerca volvulus 0.0524 0.0485 0.0476
Schistosoma mansoni serine/threonine protein kinase 0.1277 0.2024 0.3472
Trichomonas vaginalis AGC family protein kinase 0.0976 0.1408 0.5696
Brugia malayi Protein kinase domain containing protein 0.1079 0.162 0.1672
Trichomonas vaginalis AGC family protein kinase 0.0333 0.0095 0.036
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0548 0.0535 0.2057
Echinococcus multilocularis myosin iiia 0.0427 0.0286 0.0319
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0419 0.027 0.0058
Brugia malayi Immunoglobulin I-set domain containing protein 0.5027 0.9686 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0617 0.0676 0.2921
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.085 0.1152 0.1048
Echinococcus multilocularis serine:threonine protein kinase 0.0576 0.0592 0.0693
Loa Loa (eye worm) TK/KIN16 protein kinase 0.5027 0.9686 1
Plasmodium falciparum protein serine/threonine kinase-1 0.0777 0.1002 1
Schistosoma mansoni serine/threonine protein kinase 0.06 0.064 0.1069
Schistosoma mansoni vam6/vps39 related 0.0542 0.0522 0.0864
Schistosoma mansoni protein kinase C mu 0.1034 0.1526 0.2608
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0531 0.05 0.118
Giardia lamblia Kinase, NEK 0.0688 0.082 0.3528
Onchocerca volvulus Serine\/threonine kinase homolog 0.1182 0.183 0.2052
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0433 0.03 0.0337
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Loa Loa (eye worm) AGC/PKA protein kinase 0.0531 0.05 0.0516
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.2371 0.4259 0.5174
Trypanosoma brucei SNF1-related protein kinases, putative 0.0451 0.0335 0.0354
Echinococcus granulosus expressed protein 0.0419 0.027 0.0156
Giardia lamblia Kinase, CMGC GSK 0.065 0.0743 0.3031
Leishmania major protein kinase, putative 0.0777 0.1002 0.4735
Loa Loa (eye worm) hypothetical protein 0.0453 0.0341 0.0352
Echinococcus multilocularis expressed protein 0.0419 0.027 0.03
Schistosoma mansoni nck2/grb4 0.0477 0.0389 0.0632
Entamoeba histolytica protein kinase, putative 0.0419 0.027 0.0593
Echinococcus granulosus casein kinase I gamma 0.1079 0.162 0.1522
Schistosoma mansoni serine/threonine protein kinase 0.1263 0.1995 0.3421
Trichomonas vaginalis CAMK family protein kinase 0.0581 0.0602 0.242
Loa Loa (eye worm) TK/FAK protein kinase 0.2849 0.5235 0.5405
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0531 0.05 0.0388
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0542 0.0522 0.0411
Trypanosoma cruzi casein kinase, putative 0.0548 0.0535 0.2057
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0356 0.0143 0.0144
Loa Loa (eye worm) hypothetical protein 0.0453 0.0341 0.0352
Loa Loa (eye worm) AGC/PKA protein kinase 0.0531 0.05 0.0516
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0531 0.05 0.1839
Loa Loa (eye worm) hypothetical protein 0.0632 0.0706 0.0729
Echinococcus multilocularis c Jun NH2 terminal kinase 0.1338 0.2149 0.2596
Trichomonas vaginalis CAMK family protein kinase 0.0451 0.0335 0.1338
Echinococcus multilocularis tyrosine protein kinase Fgr 0.1172 0.1809 0.218
Schistosoma mansoni protein kinase 0.22 0.3909 0.6746
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0976 0.1408 0.1454
Brugia malayi Sex muscle abnormal protein 5 0.0477 0.0389 0.0401
Brugia malayi Variant SH3 domain containing protein 0.0325 0.0079 0.0082
Brugia malayi Protein kinase domain containing protein 0.0524 0.0485 0.0501
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1787 0.3065 0.3165
Trichomonas vaginalis AGC family protein kinase 0.1494 0.2467 1
Brugia malayi Kinase associated domain 1 family protein 0.0517 0.0471 0.0487
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0531 0.05 0.0388
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.1723 0.2936 0.3031
Brugia malayi Protein kinase domain containing protein 0.1494 0.2467 0.2547
Trichomonas vaginalis CK1 family protein kinase 0.0548 0.0535 0.2149
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.208 0.3664 0.4446
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0422 0.0276 0.047
Plasmodium vivax glycogen synthase kinase 3, putative 0.065 0.0743 0.7195
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.048 0.0396 0.0283
Brugia malayi Stress-activated protein kinase jnk-1 0.1338 0.2149 0.2219
Schistosoma mansoni serine/threonine protein kinase 0.0471 0.0376 0.061
Trichomonas vaginalis AGC family protein kinase 0.0735 0.0917 0.3701
Trichomonas vaginalis CMGC family protein kinase 0.06 0.064 0.2577
Loa Loa (eye worm) TK protein kinase 0.097 0.1397 0.1443
Echinococcus granulosus serine:threonine protein kinase MARK2 0.1093 0.1649 0.1551
Trypanosoma cruzi cdc2-related kinase 3 0.06 0.064 0.2703
Schistosoma mansoni protein kinase 0.0774 0.0996 0.1688
Plasmodium vivax protein kinase Crk2 0.06 0.064 0.6086
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0509 0.0454 0.0525
Loa Loa (eye worm) TK/ROR protein kinase 0.0383 0.0197 0.0203
Schistosoma mansoni serine/threonine protein kinase 0.094 0.1335 0.2276
Echinococcus multilocularis titin 0.0378 0.0187 0.0199
Echinococcus granulosus dual specificity protein kinase clk2 0.0777 0.1002 0.0896
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.1751 0.2993 0.309
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0617 0.0676 0.2663
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.085 0.1152 0.1377
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.097 0.1397 0.1296
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0372 0.0174 0.018
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0531 0.05 0.0581
Schistosoma mansoni nephrin 0.0745 0.0938 0.1585
Toxoplasma gondii AGC kinase 0.0531 0.05 0.118
Loa Loa (eye worm) hypothetical protein 0.0705 0.0854 0.0882
Echinococcus granulosus serine:threonine protein kinase MARK2 0.1093 0.1649 0.1551
Echinococcus granulosus c-Jun N-terminal kinases 0.1338 0.2149 0.2057
Echinococcus multilocularis neuroglian 0.0343 0.0116 0.0112
Echinococcus multilocularis Immunoglobulin 0.0531 0.05 0.0581
Brugia malayi STE20-like kinase MST 0.1301 0.2072 0.2139
Echinococcus multilocularis calcium dependent protein kinase 0.0345 0.0119 0.0115
Echinococcus granulosus dual specificity 0.065 0.0743 0.0634
Echinococcus granulosus insulin receptor 0.2292 0.4097 0.4028
Brugia malayi Protein kinase domain containing protein 0.3043 0.5632 0.5815
Brugia malayi Protein kinase domain containing protein 0.0617 0.0676 0.0698
Trichomonas vaginalis AGC family protein kinase 0.1494 0.2467 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.068 0.0804 0.0696
Trypanosoma cruzi casein kinase, putative 0.0548 0.0535 0.2057
Echinococcus multilocularis CDC7 cell division cycle 7 0.0452 0.0339 0.0384
Entamoeba histolytica protein kinase, putative 0.0356 0.0143 0.0206
Echinococcus granulosus mitogen activated protein kinase 0.0422 0.0276 0.0162
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0422 0.0276 0.0123
Echinococcus granulosus serine:threonine protein kinase N2 0.1509 0.2497 0.2409
Entamoeba histolytica serine/threonine protein kinase, putative 0.1182 0.183 0.5345
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0383 0.0197 0.021
Loa Loa (eye worm) protein kinase domain-containing protein 0.1079 0.162 0.1672
Schistosoma mansoni serine/threonine protein kinase 0.1079 0.162 0.277
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0531 0.05 0.1839
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0591 0.0622 0.0642
Echinococcus multilocularis tyrosine protein kinase Srms 0.097 0.1397 0.1677

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antibacterial activity against Esherichia coli ATCC 25922 at 100 ug/ml by diffusion method ChEMBL. 17289382
Activity (functional) 0 Antibacterial activity against Esherichia coli ATCC 25922 at 100 ug/ml by diffusion method ChEMBL. 17289382
MIC (functional) Antibacterial activity against Esherichia coli ATCC 25922 by macro-broth dilution assay ChEMBL. 17289382
MIC (functional) 0 Antibacterial activity against Esherichia coli ATCC 25922 by macro-broth dilution assay ChEMBL. 17289382
MIC (functional) = 6.25 ug ml-1 Antibacterial activity against Staphylococcus aureus ATCC 25923 by macro-broth dilution assay ChEMBL. 17289382
MIC (functional) = 12.5 ug ml-1 Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 by macro-broth dilution assay ChEMBL. 17289382
MIC (functional) = 12.5 ug ml-1 Antifungal activity against Candida krusei ATCC 6258 by macro-broth dilution assay ChEMBL. 17289382
MIC (functional) = 25 ug ml-1 Antifungal activity against Candida albicans ATCC 10231 by macro-broth dilution assay ChEMBL. 17289382
MIC (functional) = 25 ug ml-1 Antifungal activity against Candida albicans ATCC 10231 by macro-broth dilution assay ChEMBL. 17289382

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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