Detailed information for compound 55386

Basic information

Technical information
  • TDR Targets ID: 55386
  • Name: REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY -1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4 -I][1,6]BENZODIAZOCINE-1,3(2H)-DIONE
  • MW: 393.394 | Formula: C24H15N3O3
  • H donors: 1 H acceptors: 2 LogP: 3.8 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1[nH]c(=O)c2c1c1c3c4c2c2ccccc2n4[C@@H]2O[C@H](n3c3c1cccc3)CC2
  • InChi: 1S/C24H15N3O3/c28-23-19-17-11-5-1-3-7-13(11)26-15-9-10-16(30-15)27-14-8-4-2-6-12(14)18(22(27)21(17)26)20(19)24(29)25-23/h1-8,15-16H,9-10H2,(H,25,28,29)/t15-,16+
  • InChiKey: OTPNDVKVEAIXTI-IYBDPMFKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SB218078
  • UCM

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 4 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 4 303 aa 312 aa 29.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0519
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0081 0.0174 0.2113
Trichomonas vaginalis D-aminoacylase, putative 0.0187 0.0461 0.7966
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0034 0.0049 0.0097
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0022 0.0014 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0046
Mycobacterium ulcerans hypothetical protein 0.0163 0.0397 0.0389
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.01 0.1164
Mycobacterium ulcerans dehydrogenase 0.0022 0.0014 0.0006
Trypanosoma cruzi NADH dehydrogenase, putative 0.0022 0.0014 0.0078
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0009 0.0015
Brugia malayi nuclear hormone receptor family member odr-7 0.0055 0.0105 0.0251
Mycobacterium ulcerans lipase LipD 0.0187 0.0461 0.0453
Plasmodium falciparum glutathione reductase 0.0235 0.0589 0.0582
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.1031 0.2738 0.8276
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0022 0.0014 0.0006
Loa Loa (eye worm) hypothetical protein 0.0072 0.015 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0117 0.0273 0.0631
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0084 0.0183 0.0417
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0209 0.0478
Onchocerca volvulus 0.003 0.0036 0.0307
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0034 0.0049 0.0099
Trichomonas vaginalis set domain proteins, putative 0.023 0.0576 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0093 0.0203
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0519
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0074 0.0835
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi TAR-binding protein 0.0276 0.0699 0.1665
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.1574 0.4201 0.4196
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0649
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0024 0.0234
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus multilocularis lamin 0.0284 0.0722 0.1703
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0062 0.0123 0.0275
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0033 0.0025
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 16 0.0034 0.0049 0.0097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0157 0.0358
Plasmodium vivax hypothetical protein, conserved 0.0187 0.0461 0.0453
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0097
Echinococcus multilocularis mothers against decapentaplegic 5 0.0076 0.0161 0.0364
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Schistosoma mansoni thyroid hormone receptor 0.1436 0.383 0.9116
Echinococcus granulosus ferritin 0.0108 0.0247 0.0569
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0034 0.0049 0.0097
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0022 0.0014 0.0006
Echinococcus multilocularis ecdysone induced protein 78C 0.0117 0.0273 0.0631
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0009 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0009 0.0046
Loa Loa (eye worm) hypothetical protein 0.0052 0.0095 0.0207
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0542 0.1418 0.1411
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Schistosoma mansoni intermediate filament proteins 0.0284 0.0722 0.1704
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0009 0.0005
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.0352 0.44
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0097
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0093 0.0203
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0041
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0081 0.0174 0.2113
Brugia malayi mothers against decapentaplegic homolog 3 0.0034 0.0048 0.0113
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.1574 0.4201 0.4196
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0117 0.0273 0.0633
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0034 0.0049 0.0097
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0009 0.0015
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 12 0.0034 0.0049 0.0097
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0117 0.0273 0.0633
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0003
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Echinococcus multilocularis isocitrate dehydrogenase 0.0081 0.0174 0.0396
Giardia lamblia NADH oxidase lateral transfer candidate 0.0081 0.0175 1
Trichomonas vaginalis ferritin, putative 0.0108 0.0247 0.4198
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0022 0.0014 0.0006
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0076 0.0161 0.0364
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0076 0.086
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0033 0.006
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0117 0.0273 0.0649
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0075 0.018
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0117 0.0273 0.0633
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 23 0.0034 0.0049 0.0097
Onchocerca volvulus 0.0055 0.0105 0.1288
Trypanosoma brucei cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0548
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.01 0.0218
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus granulosus ubiquitin specific protease 41 0.0034 0.0049 0.0097
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0013 0.003
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.01 0.1192
Echinococcus granulosus ubiquitin specific peptidase 30 (C19 family) 0.0034 0.0049 0.0097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0064 0.0129 0.1545
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Loa Loa (eye worm) MH1 domain-containing protein 0.0076 0.0161 0.0364
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0014 0.0107
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0117 0.0273 0.0633
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0055 0.0105 0.0232
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0105 0.0232
Brugia malayi MH2 domain containing protein 0.1114 0.2962 0.7052
Brugia malayi Isocitrate dehydrogenase 0.0081 0.0174 0.0414
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0542 0.1418 0.1411
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0034 0.0049 0.0099
Leishmania major trypanothione reductase 0.0235 0.0589 0.7401
Echinococcus multilocularis ubiquitin specific peptidase 42 (C19 family) 0.0034 0.0049 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.0504 0.1185
Trichomonas vaginalis cyclin D, putative 0.0064 0.0129 0.2135
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0081 0.0174 0.0166
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0161 0.0389 0.0926
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0081 0.0174 0.0396
Schistosoma mansoni retinoic acid receptor RXR 0.0117 0.0273 0.0633
Echinococcus granulosus mothers against decapentaplegic 6 0.0034 0.0048 0.0094
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Loa Loa (eye worm) cyclin domain-containing protein 0.0301 0.0767 0.181
Trichomonas vaginalis cyclins, putative 0.0064 0.0129 0.2135
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0535 0.14 0.4221
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0076 0.0161 0.0366
Mycobacterium ulcerans NADH dehydrogenase 0.0022 0.0014 0.0006
Echinococcus multilocularis glutamate synthase 0.0022 0.0014 0.0015
Schistosoma mansoni apoferritin-2 0.0108 0.0247 0.0571
Schistosoma mansoni gabp alpha 0.0084 0.0183 0.0419
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0024 0.0016
Plasmodium falciparum glutathione reductase 0.0081 0.0175 0.0167
Schistosoma mansoni smad 0.0076 0.0161 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0021 0.022
Schistosoma mansoni hypothetical protein 0.0051 0.0093 0.0204
Echinococcus multilocularis tar DNA binding protein 0.0276 0.0699 0.1649
Schistosoma mansoni peptidase Clp (S14 family) 0.1574 0.4201 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0542 0.1418 0.1411
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0022 0.0014 0.0078
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0235 0.0589 0.1762
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.1574 0.4201 0.4192
Schistosoma mansoni hypothetical protein 0.011 0.0252 0.0584
Trichomonas vaginalis rotamase, putative 0.0035 0.005 0.0741
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0055 0.0111
Trichomonas vaginalis penicillin-binding protein, putative 0.0187 0.0461 0.7966
Brugia malayi cell division control protein 2 homolog 0.0053 0.01 0.0237
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0232
Schistosoma mansoni cpg binding protein 0.0035 0.005 0.0101
Echinococcus multilocularis expressed protein 0.0108 0.0247 0.0569
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0046
Mycobacterium ulcerans bacterioferritin BfrB 0.0108 0.0247 0.0239
Trichomonas vaginalis rotamase, putative 0.0034 0.0048 0.0702
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Loa Loa (eye worm) nuclear hormone receptor 0.0055 0.0105 0.0232
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0055 0.0105 0.0232
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.01 0.0218
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0041
Schistosoma mansoni glutamate synthase 0.0022 0.0014 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0117 0.0273 0.0649
Echinococcus multilocularis Smad4 0.0076 0.0161 0.0364
Loa Loa (eye worm) hypothetical protein 0.0187 0.0461 0.108
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0046
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0115 0.0256
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0022 0.0014 0.0015
Loa Loa (eye worm) nuclear factor I 0.0042 0.0069 0.0146
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0117 0.0273 0.0631
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Echinococcus granulosus mothers against decapentaplegic 2 0.0034 0.0048 0.0094
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0014 0.0107
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0022 0.0014 0.0019
Echinococcus granulosus nuclear receptor nhr 48 0.0055 0.0105 0.0232
Toxoplasma gondii isocitrate dehydrogenase 0.0081 0.0174 0.0166
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Onchocerca volvulus Alhambra homolog 0.0029 0.0033 0.0267
Echinococcus multilocularis cyclins 0.0064 0.0129 0.0289
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0034 0.0049 0.0041
Schistosoma mansoni DNA polymerase eta 0.002 0.0009 0.0005
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0041
Schistosoma mansoni smad 0.0034 0.0048 0.0096
Echinococcus granulosus mothers against decapentaplegic 5 0.0076 0.0161 0.0364
Onchocerca volvulus 0.0117 0.0273 0.3652
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 14 0.0034 0.0049 0.0097
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.1242 0.3307 1
Trichomonas vaginalis cyclins, putative 0.0064 0.0129 0.2135
Plasmodium vivax ubiquitin specific protease, putative 0.0034 0.0049 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0075 0.016
Toxoplasma gondii isocitrate dehydrogenase 0.0081 0.0174 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Echinococcus multilocularis cyclins 0.0064 0.0129 0.0289
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0117 0.0273 0.0633
Plasmodium falciparum ferrodoxin reductase-like protein 0.0022 0.0014 0.0006
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Schistosoma mansoni nuclear receptor 0.0055 0.0105 0.0234
Mycobacterium tuberculosis Probable lipase LipE 0.0187 0.0461 0.1372
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0022 0.0014 0.0015
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0022 0.0014 0.0365
Entamoeba histolytica disulphide oxidoreductase, putative 0.0022 0.0014 0.0058
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0076 0.086
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0034 0.0049 0.0099
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0022 0.0014 0.0058
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0022 0.0014 0.0107
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0036 0.0066
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0081 0.0175 0.2131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0649
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0063 0.0132
Mycobacterium tuberculosis Probable esterase LipL 0.0187 0.0461 0.1372
Schistosoma mansoni thyroid hormone receptor 0.1436 0.383 0.9116
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0123 0.0277
Trypanosoma brucei trypanothione reductase 0.0235 0.0589 0.7409
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0081 0.0175 0.0167
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0036 0.0068
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0157 0.0356
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0232
Brugia malayi Smad1 0.0076 0.0161 0.0383
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0232
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0187 0.0461 0.1097
Trypanosoma brucei NADH dehydrogenase 0.0022 0.0014 0.0108
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0041
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 24 0.0034 0.0049 0.0097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.01 0.1164
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0022 0.0014 0.0078
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.3723 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0117 0.0273 0.0631
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi nuclear hormone receptor 0.0055 0.0105 0.0251
Onchocerca volvulus 0.0055 0.0105 0.1288
Loa Loa (eye worm) Smad1 0.0076 0.0161 0.0364
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0064 0.0129 0.0289
Schistosoma mansoni smad1 5 8 and 0.0076 0.0161 0.0366
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.01 0.1164
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0055 0.0105 0.1288
Mycobacterium ulcerans hypothetical protein 0.0187 0.0461 0.0453
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Loa Loa (eye worm) hypothetical protein 0.0187 0.0461 0.108
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0055 0.0105 0.0232
Echinococcus multilocularis Ubiquitin carboxyl terminal hydrolase 48 0.0034 0.0049 0.0097
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0034 0.0049 0.0097
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 16 0.0034 0.0049 0.0097
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0123 0.0294
Toxoplasma gondii hypothetical protein 0.005 0.0091 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Loa Loa (eye worm) glutathione reductase 0.0235 0.0589 0.1386
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0117 0.0273 0.0631
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0081 0.0175 0.2155
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0022 0.0014 0.0015
Echinococcus multilocularis cyclin b3 0.0064 0.0129 0.0289
Schistosoma mansoni sulfide quinone reductase 0.0022 0.0014 0.0016
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0036 0.0066
Toxoplasma gondii ubiquitin-specific protease USP4 0.0034 0.0049 0.0041
Schistosoma mansoni smad1 5 8 and 0.0076 0.0161 0.0366
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0022 0.0014 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0117 0.0273 0.0649
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0013 0.0087
Brugia malayi intermediate filament protein 0.0284 0.0722 0.1719
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.1574 0.4201 1
Plasmodium falciparum thioredoxin reductase 0.0081 0.0175 0.0167
Schistosoma mansoni ferritin 0.0108 0.0247 0.0571
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0081 0.0174 0.0396
Brugia malayi Intermediate filament tail domain containing protein 0.0284 0.0722 0.1719
Schistosoma mansoni calpain-7 (C02 family) 0.0034 0.0049 0.0099
Mycobacterium tuberculosis Probable lipase LipD 0.0187 0.0461 0.1372
Echinococcus granulosus intermediate filament protein 0.0284 0.0722 0.1703
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Onchocerca volvulus 0.0034 0.0049 0.0489
Schistosoma mansoni ets-related 0.0255 0.0645 0.152
Brugia malayi CXXC zinc finger family protein 0.0035 0.005 0.0118
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.0252 0.06
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0034 0.0049 0.0097
Echinococcus granulosus cyclin dependent kinase 0.0053 0.01 0.0218
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0097
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0501 0.1176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0081 0.0175 0.2131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0051 0.0758
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0046
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0034 0.0049 0.0097
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0048 0.0094
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0117 0.0273 0.0631
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0152 0.0366 0.0854
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0097
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.1574 0.4201 0.4196
Echinococcus multilocularis cyclins 0.0064 0.0129 0.0289
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0352 0.4383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0058 0.0881
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0024 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0117 0.0273 0.0631
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0034 0.0049 0.0099
Entamoeba histolytica cyclin, putative 0.0064 0.0129 0.116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0649
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0105 0.0234
Echinococcus granulosus Nuclear hormone receptor HR96 0.0055 0.0105 0.0232
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0649
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.01 0.1609
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 20 0.0034 0.0049 0.0097
Giardia lamblia Hypothetical protein 0.0064 0.0129 0.7251
Loa Loa (eye worm) hypothetical protein 0.1574 0.4201 1
Echinococcus granulosus smad 0.0076 0.0161 0.0364
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0076 0.0161
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0161 0.0389 0.0909
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.0352 0.4383
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0009 0.0015
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0036 0.0066
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Trypanosoma cruzi cyclin, putative 0.0064 0.0129 0.1545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0649
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0034 0.0049 0.0099
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0075 0.016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0117 0.0273 0.0649
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Brugia malayi Fli-1 protein 0.0255 0.0645 0.1535
Echinococcus multilocularis nuclear receptor nhr 48 0.0055 0.0105 0.0232
Echinococcus multilocularis mothers against decapentaplegic 2 0.0034 0.0048 0.0094
Schistosoma mansoni nuclear hormone receptor 0.0117 0.0273 0.0633
Giardia lamblia GTOR 0.0044 0.0076 0.4037
Schistosoma mansoni hypothetical protein 0.0051 0.0093 0.0204
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.005 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Schistosoma mansoni cyclin B3 0.0064 0.0129 0.0291
Loa Loa (eye worm) hypothetical protein 0.0132 0.0312 0.0724
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0187 0.0461 0.1372
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.01 0.0218
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0022 0.0014 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0046
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0034 0.0049 0.0097
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0081 0.0174 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0028 0.0341
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0108 0.0247 0.0239
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Giardia lamblia Kinase, CMGC CDK 0.0053 0.01 0.5464
Plasmodium vivax SET domain protein, putative 0.003 0.0036 0.0028
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.039
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Echinococcus multilocularis ferritin 0.0108 0.0247 0.0569
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.005 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0117 0.0273 0.0649
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0034 0.0049 0.0097
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0081 0.0175 0.0167
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0022 0.0014 0.0015
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0022 0.0014 0.0006
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0076 0.0161
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0105 0.0232
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0041
Schistosoma mansoni ferritin light chain 0.0108 0.0247 0.0571
Schistosoma mansoni peptidase 0.0036 0.0053 0.011
Schistosoma mansoni ferritin 0.0108 0.0247 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Echinococcus multilocularis peptidase Clp (S14 family) 0.1031 0.2738 0.6512
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0046
Echinococcus granulosus peregrin 0.0029 0.0033 0.006
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Loa Loa (eye worm) hypothetical protein 0.0279 0.0708 0.1669
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0699 0.165
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0232
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.01 0.0218
Brugia malayi hypothetical protein 0.0055 0.0105 0.0251
Loa Loa (eye worm) hypothetical protein 0.0034 0.0048 0.0094
Schistosoma mansoni hypothetical protein 0.0051 0.0093 0.0204
Giardia lamblia DINP protein human, muc B family 0.002 0.0009 0.0071
Schistosoma mansoni hypothetical protein 0.0022 0.0014 0.0016
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0022 0.0014 0.0006
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0081 0.0174 0.0166
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0062 0.0123 0.0275
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0117 0.0273 0.0649
Toxoplasma gondii selenide, water dikinase 0.0022 0.0014 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0699 0.165
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0519
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0022 0.0014 0.0006
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0034 0.0049 0.0097
Toxoplasma gondii NADPH-glutathione reductase 0.0081 0.0175 0.0167
Loa Loa (eye worm) nuclear receptor NHR-67 0.0055 0.0105 0.0232
Echinococcus granulosus beta LACTamase domain containing family member 0.0187 0.0461 0.108
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0009 0.0001
Loa Loa (eye worm) DR-78 0.0055 0.0105 0.0232
Plasmodium falciparum phd finger protein, putative 0.0029 0.0033 0.0025
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.01 0.022
Mycobacterium tuberculosis Conserved protein 0.0187 0.0461 0.1372
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0209 0.0478
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0055 0.0113
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0081 0.0175 0.0167
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi RNA recognition motif domain containing protein 0.0276 0.0699 0.1665
Trichomonas vaginalis cyclin B3, putative 0.0064 0.0129 0.2135
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0022 0.0014 0.0015
Brugia malayi nuclear receptor NHR-88 0.0117 0.0273 0.0649
Loa Loa (eye worm) hypothetical protein 0.0137 0.0326 0.0757
Echinococcus granulosus cpg binding protein 0.0037 0.0055 0.0112
Mycobacterium ulcerans hypothetical protein 0.0022 0.0014 0.0006
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0034 0.0049 0.0097
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0048 0.0508
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0034 0.0049 0.0097
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.0793 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0187 0.0461 0.1372
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0519
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0009 0.0015
Echinococcus multilocularis cyclins 0.0064 0.0129 0.0289
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0099 0.1163
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0022 0.0014 0.0015
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0051 0.055
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.0461 0.5765
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0002
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0009 0.0021
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0034 0.0049 0.0116
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0097
Toxoplasma gondii thioredoxin reductase 0.0235 0.0589 0.0582
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0033 0.0025
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Echinococcus granulosus dnaJ subfamily B 0.0494 0.1288 0.3054
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0097
Leishmania major hypothetical protein, conserved 0.0022 0.0014 0.0078
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase family 2, putative 0.0034 0.0049 0.0041
Schistosoma mansoni apoferritin-2 0.0108 0.0247 0.0571
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 47 0.0034 0.0049 0.0097
Echinococcus granulosus lamin 0.0284 0.0722 0.1703
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Onchocerca volvulus 0.0035 0.005 0.0499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0076 0.1189
Echinococcus granulosus ubiquitin specific peptidase c family 0.0034 0.0049 0.0097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Onchocerca volvulus Bile acid receptor homolog 0.0117 0.0273 0.3652
Trypanosoma cruzi NADH dehydrogenase, putative 0.0022 0.0014 0.0078
Trypanosoma cruzi Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0519
Schistosoma mansoni steroid hormone receptor ad4bp 0.0117 0.0273 0.0633
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0048 0.0537
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0108 0.0247 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Trichomonas vaginalis D-aminoacylase, putative 0.0187 0.0461 0.7966
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis Harbinger-1_Harbinger/PIFA2 transposable element protein 0.0034 0.0049 0.0717
Toxoplasma gondii hypothetical protein 0.0542 0.1418 0.1411
Loa Loa (eye worm) hypothetical protein 0.0062 0.0123 0.0275
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0034 0.0049 0.0097
Echinococcus granulosus expressed protein 0.0108 0.0247 0.0569
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0015
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0062 0.0123 0.0275
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0022 0.0014 0.0015
Giardia lamblia Glutamate synthase 0.0022 0.0014 0.0365
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0055 0.0105 0.0232
Loa Loa (eye worm) cyclin domain-containing protein 0.0064 0.0129 0.0289
Giardia lamblia Thioredoxin reductase 0.0022 0.0014 0.0365
Brugia malayi Pre-SET motif family protein 0.003 0.0036 0.0086
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0034 0.0049 0.0099
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0081 0.0175 0.2155
Echinococcus multilocularis cyclins 0.0064 0.0129 0.0289
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 24 0.0034 0.0049 0.0097
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0519
Mycobacterium tuberculosis Conserved protein 0.0187 0.0461 0.1372
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0081 0.0174 0.0396
Echinococcus granulosus cyclins 0.0064 0.0129 0.0289
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0519
Loa Loa (eye worm) hypothetical protein 0.0042 0.0069 0.0146
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.01 0.0218
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0081 0.0175 0.2131
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.1031 0.2738 0.8276
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 12 0.0034 0.0049 0.0097
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0034 0.0049 0.0097
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0036 0.0068
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0081 0.0175 0.2131
Echinococcus multilocularis FTZ F1 alpha 0.0117 0.0273 0.0631
Trichomonas vaginalis glutathione reductase, putative 0.0081 0.0175 0.2944
Trypanosoma brucei unspecified product 0.002 0.0009 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0117 0.0273 0.0649
Schistosoma mansoni sulfide quinone reductase 0.0022 0.0014 0.0016
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0034 0.0049 0.2436
Brugia malayi MH1 domain containing protein 0.0042 0.0069 0.0165
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Plasmodium falciparum thioredoxin reductase 0.0235 0.0589 0.0582
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0117 0.0273 0.0649
Schistosoma mansoni cpg binding protein 0.0037 0.0055 0.0113
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.1574 0.4201 0.4192
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0076 0.0646
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Loa Loa (eye worm) hypothetical protein 0.0117 0.0273 0.0631
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0022 0.0014 0.0108
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0097
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0014 0.0108
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0034 0.045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0117 0.0273 0.0631
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi steroid hormone receptor 0.0117 0.0273 0.0649
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0076 0.018
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0081 0.0175 0.0401
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0074 0.0835
Echinococcus granulosus cyclin B 0.0064 0.0129 0.0289
Echinococcus granulosus thioredoxin glutathione reductase 0.0235 0.0591 0.1389
Brugia malayi Bromodomain containing protein 0.0029 0.0033 0.0079
Loa Loa (eye worm) hypothetical protein 0.0132 0.0312 0.0724
Schistosoma mansoni disulfide oxidoreductase 0.0022 0.0014 0.0016
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0009 0.0004
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0055 0.0105 0.0251
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0187 0.0461 0.108
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase family 2 protein 0.0034 0.0049 0.0041
Loa Loa (eye worm) hypothetical protein 0.0187 0.0461 0.108
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1196 0.3181 0.9619
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0034 0.0049 0.0097
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0055 0.0111
Echinococcus multilocularis cyclins 0.0064 0.0129 0.0289
Trichomonas vaginalis D-aminoacylase, putative 0.0187 0.0461 0.7966
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0022 0.0014 0.0058
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0203 0.0504 0.1183
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0034 0.0049 0.0041
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0081 0.0174 0.0398
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Giardia lamblia DUB-1 0.0034 0.0049 0.2436
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0028 0.0341
Echinococcus granulosus tar DNA binding protein 0.0276 0.0699 0.1649
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi Cyclin, N-terminal domain containing protein 0.0064 0.0129 0.0308
Trypanosoma cruzi CYC2-like cyclin, putative 0.0064 0.0129 0.1545
Brugia malayi MH1 domain containing protein 0.0076 0.0161 0.0383
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0022 0.0014 0.0058
Brugia malayi Cyclin, N-terminal domain containing protein 0.0064 0.0129 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0051 0.0758
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0033 0.0025
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0022 0.0014 0.0015
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0535 0.14 0.4221
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Onchocerca volvulus 0.0034 0.0049 0.0489
Echinococcus granulosus GPCR family 2 0.0051 0.0093 0.0203
Leishmania major DNA polymerase kappa, putative 0.002 0.0009 0.0015
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0081 0.0175 0.2155
Schistosoma mansoni nuclear receptor nhr-48 0.0055 0.0105 0.0234
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Loa Loa (eye worm) hypothetical protein 0.0117 0.0273 0.0631
Echinococcus granulosus GA binding protein alpha chain 0.0084 0.0183 0.0417
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0048 0.0508
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0033 0.0062
Echinococcus granulosus cyclin B3 1 0.0064 0.0129 0.0289
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.1031 0.2738 0.2728
Brugia malayi Pre-SET motif family protein 0.0202 0.0501 0.1193
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0041
Schistosoma mansoni ferritin 0.0108 0.0247 0.0571
Mycobacterium tuberculosis Probable reductase 0.0535 0.14 0.4221
Echinococcus granulosus cyclin b3 0.0064 0.0129 0.0289
Leishmania major hypothetical protein, conserved 0.0022 0.0014 0.0078
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Trypanosoma cruzi Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0519
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0117 0.0273 0.0631
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0081 0.0175 0.0161
Onchocerca volvulus 0.0064 0.0129 0.1628
Echinococcus granulosus cyclins 0.0064 0.0129 0.0289
Loa Loa (eye worm) hypothetical protein 0.0187 0.0461 0.108
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0137 0.0326 0.0757
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.006 0.0117 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0129 0.2135
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0036 0.0495
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0081 0.0175 0.0167
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0024 0.0204
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0076 0.086
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 2, putative 0.0034 0.0049 0.0041
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0055 0.0105 0.0232
Entamoeba histolytica hypothetical protein 0.0407 0.1054 1
Schistosoma mansoni Smad4 0.0034 0.0048 0.0096
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0034 0.0049 0.0099
Loa Loa (eye worm) hypothetical protein 0.0117 0.0273 0.0631
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0117 0.0273 0.0649
Brugia malayi Cyclin, N-terminal domain containing protein 0.0301 0.0767 0.1826
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0022 0.0014 0.0108
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0595 0.1562 0.155
Brugia malayi glutathione reductase 0.0235 0.0589 0.1403
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi MH1 domain containing protein 0.0076 0.0161 0.0383
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Loa Loa (eye worm) steroid hormone receptor 0.0117 0.0273 0.0631
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0097
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0081 0.0175 0.0167
Trypanosoma brucei hypothetical protein, conserved 0.0187 0.0461 0.5779
Mycobacterium tuberculosis Probable oxidoreductase 0.0595 0.1562 0.4709
Brugia malayi Steroid receptor seven-up type 2 0.0117 0.0273 0.0649
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0232
Brugia malayi cytoplasmic intermediate filament protein 0.0152 0.0366 0.0872
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0046
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0097
Echinococcus multilocularis beta LACTamase domain containing family member 0.0187 0.0461 0.108
Schistosoma mansoni lamin 0.0284 0.0722 0.1704
Plasmodium falciparum ubiquitin specific protease, putative 0.0034 0.0049 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.1574 0.4201 0.4196
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0081 0.0175 0.2131
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0022 0.0014 0.0006
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 0.0034 0.0049 0.0097
Echinococcus granulosus FTZ F1 alpha 0.0117 0.0273 0.0631
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0075 0.0162
Schistosoma mansoni zinc finger protein 0.0055 0.0105 0.0234
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 20 0.0034 0.0049 0.0097
Trypanosoma cruzi trypanothione reductase, putative 0.0235 0.0589 0.7401
Echinococcus multilocularis cpg binding protein 0.0037 0.0055 0.0112
Schistosoma mansoni Smad4 0.0076 0.0161 0.0366
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0034 0.0049 0.0099
Schistosoma mansoni nuclear receptor 0.0055 0.0105 0.0234
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0014 0.0078
Trypanosoma brucei Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Giardia lamblia G2/mitotic-specific cyclin B 0.0064 0.0129 0.7251
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0009 0.0022
Toxoplasma gondii hypothetical protein 0.0034 0.0049 0.0041
Schistosoma mansoni cyclins 0.0064 0.0129 0.0291
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0034 0.0049 0.0097
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.3723 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0036 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0014 0.0078
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0055 0.0105 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0051 0.0758
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.1319 0.3513 0.8361
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 14 0.0034 0.0049 0.0097
Mycobacterium ulcerans ferredoxin reductase 0.0022 0.0014 0.0006
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0108 0.0247 0.0723
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.01 0.1609
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0022 0.0014 0.0107
Schistosoma mansoni hypothetical protein 0.0034 0.0049 0.0099
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0232
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0022 0.0014 0.0006
Brugia malayi ecdysteroid receptor 0.0117 0.0273 0.0649
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0014 0.0108
Schistosoma mansoni ferritin light chain 0.0108 0.0247 0.0571
Loa Loa (eye worm) hypothetical protein 0.0117 0.0273 0.0631
Loa Loa (eye worm) hypothetical protein 0.0051 0.0093 0.0203
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0022 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0062 0.0123 0.0275
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0097
Leishmania major ubiqitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0187 0.0461 0.1372
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0034 0.0049 0.0099
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Schistosoma mansoni hypothetical protein 0.0029 0.0033 0.0062
Schistosoma mansoni ferritin 0.0108 0.0247 0.0571
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0136 0.0128
Trypanosoma cruzi cyclin, putative 0.0064 0.0129 0.1545
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0014 0.0107
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.01 0.1164
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.01 0.0091
Brugia malayi jmjC domain containing protein 0.0094 0.0209 0.0497
Trichomonas vaginalis Harbinger-1_Harbinger/PIFA2 transposable element protein 0.0034 0.0049 0.0717
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0009 0.0021
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0093 0.0222
Echinococcus multilocularis expressed protein 0.0034 0.0049 0.0097
Echinococcus granulosus dna polymerase eta 0.002 0.0009 0.0003
Brugia malayi Protein kinase domain containing protein 0.0053 0.01 0.0237
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.01 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0076 0.1189
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0076 0.0161
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Entamoeba histolytica hypothetical protein 0.0407 0.1054 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0064 0.0129 0.0308
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0014 0.0078
Echinococcus granulosus expressed protein 0.0035 0.005 0.01
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0022 0.0014 0.0058
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0024 0.0016
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0051 0.055
Trichomonas vaginalis cyclins, putative 0.0064 0.0129 0.2135
Schistosoma mansoni hypothetical protein 0.0051 0.0093 0.0204
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Onchocerca volvulus 0.0284 0.0722 1
Brugia malayi RNA binding protein 0.0276 0.0699 0.1665
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0022 0.0014 0.0006
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.01 0.1164
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.1574 0.4201 0.4196
Echinococcus granulosus ecdysone induced protein 78C 0.0117 0.0273 0.0631
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0649
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0048 0.0094
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0034 0.0049 0.0099
Trichomonas vaginalis cyclin B, putative 0.0064 0.0129 0.2135
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0051 0.0579
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0105 0.0234
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 2, putative 0.0034 0.0049 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0046
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.3723 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0117 0.0273 0.0631
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0021 0.022
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0081 0.0175 0.0167
Brugia malayi jmjC domain containing protein 0.0037 0.0055 0.013
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus multilocularis thioredoxin glutathione reductase 0.0235 0.0591 0.1389
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis ubiquitin specific protease, putative 0.0034 0.0049 0.0717
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0031 0.0055
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0022 0.0014 0.0078
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Loa Loa (eye worm) hypothetical protein 0.0062 0.0123 0.0275
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0055 0.0105 0.1288
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0041
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0117 0.0273 0.0631
Echinococcus granulosus Ubiquitin carboxyl terminal hydrolase 48 0.0034 0.0049 0.0097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0055 0.0105 0.0234
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus granulosus cyclins 0.0064 0.0129 0.0289
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0009 0.0005
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0022 0.0014 0.0006
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.0793 1
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0022 0.0014 0.0006
Schistosoma mansoni hypothetical protein 0.1319 0.3513 0.8361
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0009 0.0003
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.1574 0.4201 1
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0034 0.0049 0.0099
Brugia malayi Nuclear hormone receptor-like 1 0.0117 0.0273 0.0649
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0034 0.0049 0.0097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis cyclins, putative 0.0064 0.0129 0.2135
Leishmania major hypothetical protein, conserved 0.0025 0.0024 0.0204
Onchocerca volvulus 0.0284 0.0722 1
Toxoplasma gondii ABC1 family protein 0.0187 0.0461 0.0453
Brugia malayi hypothetical protein 0.0034 0.0049 0.0116
Mycobacterium ulcerans monoxygenase 0.0022 0.0014 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0117 0.0273 0.0649
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0022 0.0014 0.0078
Brugia malayi Nuclear hormone receptor E75 0.0055 0.0105 0.0251
Schistosoma mansoni glutamate synthase 0.0022 0.0014 0.0016
Echinococcus multilocularis GPCR, family 2 0.0051 0.0093 0.0203
Leishmania major DNA polymerase eta, putative 0.002 0.0009 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0051 0.0758
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0034 0.0049 0.0099
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0535 0.14 0.4221
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0076 0.0888
Schistosoma mansoni rotamase 0.0035 0.005 0.0102
Brugia malayi glutamate synthase 0.0022 0.0014 0.0034
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.1288 0.3054
Plasmodium vivax glutathione reductase, putative 0.0235 0.0589 0.0582
Brugia malayi MH2 domain containing protein 0.0076 0.0161 0.0383
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Trichomonas vaginalis cyclin B, putative 0.0064 0.0129 0.2135
Loa Loa (eye worm) transcription factor SMAD2 0.1114 0.2962 0.7046
Brugia malayi MH2 domain containing protein 0.0034 0.0048 0.0113
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0232
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.3723 1 1
Brugia malayi nuclear receptor RXR 0.0062 0.0123 0.0294
Onchocerca volvulus 0.0034 0.0049 0.0489
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.3723 1 1
Toxoplasma gondii hypothetical protein 0.0049 0.0088 0.008
Leishmania major NADH dehydrogenase, putative 0.0022 0.0014 0.0078
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0034 0.0049 0.039
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0048 0.0508
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.01 0.1164
Echinococcus multilocularis cyclins 0.0064 0.0129 0.0289
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0046
Trichomonas vaginalis mercuric reductase, putative 0.0081 0.0175 0.2944
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0081 0.0174 0.0396
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0074 0.0835
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0407 0.1054 0.2495
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Mycobacterium ulcerans bacterioferritin BfrA 0.0108 0.0247 0.0239
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.1574 0.4201 0.4196
Loa Loa (eye worm) TAR-binding protein 0.0276 0.0699 0.1649
Brugia malayi hypothetical protein 0.0407 0.1054 0.251
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 36 0.0034 0.0049 0.0097
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0097
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0008 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0027 0.0329
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 14 0.0034 0.0049 0.0041
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.1574 0.4201 0.4196
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0022 0.0014 0.0034
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0009 0.0046
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0097
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.01 0.1609
Echinococcus granulosus lamin dm0 0.0284 0.0722 0.1703
Echinococcus multilocularis cyclin B3 1 0.0064 0.0129 0.0289
Trichomonas vaginalis Harbinger-1_Harbinger/PIFA2 transposable element protein 0.0034 0.0049 0.0717
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0519
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0041
Echinococcus granulosus cyclins 0.0064 0.0129 0.0289
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0117 0.0273 0.0631
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0034 0.0049 0.2436
Schistosoma mansoni glutamate synthase 0.0022 0.0014 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0075 0.0162
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0048 0.0381
Entamoeba histolytica cyclin family protein 0.0064 0.0129 0.116
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Plasmodium falciparum cyclin 0.0064 0.0129 0.0121
Entamoeba histolytica hypothetical protein 0.0034 0.0049 0.039
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0081 0.0175 0.2131
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0407 0.1054 0.2495
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0034 0.0049 0.2436
Mycobacterium leprae Probable lipase LipE 0.0187 0.0461 0.0447
Schistosoma mansoni hypothetical protein 0.0494 0.1288 0.3055
Echinococcus multilocularis peregrin 0.0029 0.0033 0.006
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0022 0.0014 0.0015
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0034 0.0048 0.047
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Plasmodium vivax protein kinase Crk2 0.0053 0.01 0.0091
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0187 0.0461 0.0453
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0022 0.0014 0.0015
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0034 0.0049 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0187 0.0461 0.1081
Echinococcus multilocularis lamin dm0 0.0284 0.0722 0.1703
Echinococcus granulosus dna polymerase kappa 0.002 0.0009 0.0003
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0022 0.0014 0.0058
Onchocerca volvulus 0.0187 0.0461 0.6309
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0041
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0024 0.0204
Loa Loa (eye worm) intermediate filament protein 0.0284 0.0722 0.1703
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0595 0.1562 0.4709
Loa Loa (eye worm) thioredoxin reductase 0.0235 0.0589 0.1386
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0081 0.0175 0.2131
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0081 0.0175 0.2155
Trichomonas vaginalis glutamate synthase, putative 0.0022 0.0014 0.0107
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0284 0.0722 0.1703
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0022 0.0014 0.0034
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.1574 0.4201 0.4196
Giardia lamblia Hypothetical protein 0.0034 0.0049 0.2436
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0041
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0076 0.0163
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0022 0.0014 0.0034
Brugia malayi Thioredoxin reductase 0.0235 0.0589 0.1403
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0081 0.0175 0.2131
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0034 0.0049 0.0097
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0034 0.0049 0.0041
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0097
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0117 0.0273 0.0631
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0036 0.0068
Plasmodium falciparum ubiquitin specific protease, putative 0.0034 0.0049 0.0041
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0022 0.0014 0.0006
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0093 0.0222
Loa Loa (eye worm) hypothetical protein 0.0187 0.0461 0.108
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0034 0.0049 0.0097
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0081 0.0175 0.0507
Loa Loa (eye worm) hypothetical protein 0.0161 0.0389 0.0909
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0009 0.0003
Mycobacterium tuberculosis Probable hydrolase 0.0187 0.0461 0.1372
Echinococcus multilocularis mothers against decapentaplegic 6 0.0034 0.0048 0.0094
Schistosoma mansoni smad1 5 8 and 0.0076 0.0161 0.0366
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Brugia malayi orphan nuclear receptor NR2E1 0.0055 0.0105 0.0251
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0009 0.0015
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 36 0.0034 0.0049 0.0097
Loa Loa (eye worm) hypothetical protein 0.0117 0.0273 0.0631
Loa Loa (eye worm) hypothetical protein 0.0117 0.0273 0.0631
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0081 0.0175 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0117 0.0273 0.0649
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0699 0.165
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0041
Brugia malayi beta-lactamase family protein 0.0187 0.0461 0.1097
Brugia malayi nuclear hormone receptor family member nhr-6 0.0055 0.0105 0.0251
Leishmania major mitochondrial DNA polymerase beta 0.031 0.0793 1
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0076 0.1189
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0117 0.0273 0.0631
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0021 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Brugia malayi nuclear receptor RXR 0.0055 0.0105 0.0251
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0036 0.0028
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Onchocerca volvulus 0.0187 0.0461 0.6309
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.01 0.1192
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0232
Loa Loa (eye worm) hypothetical protein 0.0062 0.0123 0.0275
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Loa Loa (eye worm) MH2 domain-containing protein 0.0076 0.0161 0.0364
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis apoptosis inducing factor, putative 0.0022 0.0014 0.0107
Brugia malayi isocitrate dehydrogenase 0.0081 0.0174 0.0414
Trypanosoma brucei Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0022 0.0014 0.0019
Schistosoma mansoni cyclin B 0.0064 0.0129 0.0291
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0034 0.0049 0.0097
Echinococcus multilocularis dna polymerase eta 0.002 0.0009 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Schistosoma mansoni Smad4 0.0034 0.0048 0.0096
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0232
Brugia malayi nuclear hormone receptor 0.0117 0.0273 0.0649
Brugia malayi hypothetical protein 0.0062 0.0123 0.0294
Onchocerca volvulus 0.0187 0.0461 0.6309
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0699 0.165
Giardia lamblia Kinase, CMGC CDK 0.0053 0.01 0.5464
Loa Loa (eye worm) hypothetical protein 0.0117 0.0273 0.0631
Echinococcus granulosus thyroid hormone receptor alpha 0.0055 0.0105 0.0232
Trypanosoma cruzi hypothetical protein, conserved 0.0187 0.0461 0.5765
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0117 0.0273 0.0631
Mycobacterium tuberculosis Conserved protein 0.0187 0.0461 0.1372
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0117 0.0273 0.3652
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 1, putative 0.0034 0.0049 0.0041
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0014 0.0107
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0064 0.0129 0.0289
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0022 0.0014 0.0019
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0008 0.0019
Onchocerca volvulus 0.023 0.0576 0.7942
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0022 0.0014 0.0107
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0542 0.1418 0.1406
Loa Loa (eye worm) hypothetical protein 0.0187 0.0461 0.108
Schistosoma mansoni RAR-like nuclear receptor 0.0117 0.0273 0.0633
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0075 0.016
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0232
Leishmania major hypothetical protein, conserved 0.0187 0.0461 0.5765
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0022 0.0014 0.0015
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi hypothetical protein 0.0062 0.0123 0.0294
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0021 0.0218
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0595 0.1562 0.4709
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0034 0.0049 0.0116
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0081 0.0175 0.0399
Echinococcus multilocularis musashi 0.0284 0.0722 0.1703
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0045 0.0037
Loa Loa (eye worm) fli-1 protein 0.0255 0.0645 0.1519
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.005 0.01
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0081 0.0175 0.2131
Echinococcus granulosus glutamate synthase 0.0022 0.0014 0.0015
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0055 0.0105 0.0234
Loa Loa (eye worm) MH2 domain-containing protein 0.1114 0.2962 0.7046
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0117 0.0273 0.0649
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.3723 1 1
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0097
Schistosoma mansoni transcription factor LCR-F1 0.0407 0.1054 0.2496
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0535 0.14 0.4221
Treponema pallidum bacterioferrin (TpF1) 0.0108 0.0247 0.0239
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0117 0.0273 0.0631
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0081 0.0174 0.2138
Echinococcus multilocularis ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase 0.0034 0.0049 0.0097
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0014 0.0108
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0081 0.0175 0.0399
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0117 0.0273 0.0633
Trypanosoma cruzi trypanothione reductase, putative 0.0081 0.0175 0.2131
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0034 0.0049 0.0099
Entamoeba histolytica cyclin, putative 0.0064 0.0129 0.116
Echinococcus granulosus jumonji domain containing protein 0.004 0.0063 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Trichomonas vaginalis cyclin B, putative 0.0064 0.0129 0.2135
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.01 0.0218
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0009 0.0046
Brugia malayi ecdysone receptor 0.0055 0.0105 0.0251
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0034 0.0049 0.0097
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0022 0.0014 0.0015
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0034 0.0049 0.0097
Brugia malayi nuclear receptor NHR-67 0.0055 0.0105 0.0251
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0034 0.0049 0.0099
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0022 0.0014 0.0019
Brugia malayi PHD-finger family protein 0.0029 0.0033 0.0079
Brugia malayi nuclear receptor NHR-88 0.0055 0.0105 0.0251
Entamoeba histolytica cyclin family protein 0.0064 0.0129 0.116
Brugia malayi conserved hypotetical protein 0.0055 0.0105 0.0251
Trypanosoma brucei mitotic cyclin 6 0.0064 0.0129 0.1571
Giardia lamblia PHD finger protein 15 0.0029 0.0033 0.1496
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0022 0.0014 0.0006
Entamoeba histolytica hypothetical protein 0.0407 0.1054 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0022 0.0014 0.0006
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.1574 0.4201 0.4192
Trichomonas vaginalis cyclin B, putative 0.0064 0.0129 0.2135
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0034 0.0049 0.0041
Brugia malayi MH1 domain containing protein 0.0042 0.0069 0.0165
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0097
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0055 0.0113
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.3723 1 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.01 0.0218
Mycobacterium ulcerans glutamate synthase subunit beta 0.0022 0.0014 0.0006
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0081 0.0175 0.0167
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.01 0.0874
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0117 0.0273 0.0631
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.01 0.0218
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0034 0.0049 0.0099
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0034 0.0049 0.039
Entamoeba histolytica thioredoxin reductase, putative 0.0022 0.0014 0.0058
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0009 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0021 0.022
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0232
Brugia malayi Ets-domain containing protein 0.0084 0.0183 0.0435
Mycobacterium ulcerans esterase/lipase LipP 0.0187 0.0461 0.0453
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Schistosoma mansoni hypothetical protein 0.0407 0.1054 0.2496
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0232
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0076 0.0888
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.0033 0.006
Echinococcus granulosus Nuclear hormone receptor HR96 0.0055 0.0105 0.0232
Echinococcus granulosus 5'partial|Ubiquitin carboxyl terminal hydrolase 48 0.0034 0.0049 0.0097
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0081 0.0175 0.2131
Loa Loa (eye worm) RNA binding protein 0.0276 0.0699 0.1649
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Schistosoma mansoni cpg binding protein 0.0037 0.0055 0.0113
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0028 0.0341
Echinococcus granulosus Smad4 0.0076 0.0161 0.0364
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0034 0.0049 0.0099
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0137 0.0326 0.0757
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0535 0.14 0.1388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0045 0.0649
Brugia malayi beta-lactamase 0.0187 0.0461 0.1097
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0123 0.0294
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0093 0.0203
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0062 0.0123 0.0277
Entamoeba histolytica hypothetical protein 0.0407 0.1054 1
Trichomonas vaginalis Harbinger-1_Harbinger/PIFA2 transposable element protein 0.0034 0.0049 0.0717
Echinococcus multilocularis thyroid hormone receptor alpha 0.1436 0.383 0.9116
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0034 0.0049 0.0099
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0009 0.0004
Brugia malayi hypothetical protein 0.0025 0.0024 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0117 0.0273 0.0631
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Schistosoma mansoni calpain-7 (C02 family) 0.0034 0.0049 0.0099
Loa Loa (eye worm) beta-lactamase 0.0187 0.0461 0.108
Loa Loa (eye worm) hypothetical protein 0.0055 0.0105 0.0232
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0117 0.0273 0.0631
Echinococcus multilocularis ubiquitin specific protease 41 0.0034 0.0049 0.0097
Trichomonas vaginalis ubiquitin specific protease, putative 0.0034 0.0049 0.0717
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Echinococcus multilocularis cyclin B 0.0064 0.0129 0.0289
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0187 0.0461 0.1081
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0022 0.0014 0.0107
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi MH2 domain containing protein 0.0076 0.0161 0.0383
Trypanosoma brucei mitochondrial DNA polymerase beta 0.031 0.0793 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Schistosoma mansoni ap endonuclease 0.0019 0.0008 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.005 0.0741
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Loa Loa (eye worm) hypothetical protein 0.0062 0.0123 0.0275
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Echinococcus granulosus cyclins 0.0064 0.0129 0.0289
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0009 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0108 0.0247 0.0723
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0034 0.0049 0.0099
Mycobacterium tuberculosis Probable dehydrogenase 0.0535 0.14 0.4221
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0081 0.0174 0.2113
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.01 0.022
Mycobacterium leprae conserved hypothetical protein 0.0187 0.0461 0.0447
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis penicillin-binding protein, putative 0.0187 0.0461 0.7966
Echinococcus multilocularis expressed protein 0.0035 0.005 0.01
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0022 0.0014 0.0006
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0033 0.006
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0022 0.0014 0.0078
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0093 0.0203
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0009 0.0001
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0076 0.086
Schistosoma mansoni coup transcription factor 0.0117 0.0273 0.0633
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0081 0.0174 0.0396
Echinococcus multilocularis smad 0.0076 0.0161 0.0364
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0009 0.0046
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0075 0.016
Brugia malayi Probable ClpP-like protease 0.1574 0.4201 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0081 0.0175 0.0167
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.01 0.0874
Echinococcus multilocularis dna polymerase kappa 0.002 0.0009 0.0003
Loa Loa (eye worm) isocitrate dehydrogenase 0.0081 0.0174 0.0396
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0014 0.0107
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0034 0.0049 0.0041
Leishmania major cyclin 0.0064 0.0129 0.1545
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0022 0.0014 0.0006
Trichomonas vaginalis esterase, putative 0.0187 0.0461 0.7966
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0048 0.004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0161 0.0389 0.0926
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.006 0.0117 0.0279
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Brugia malayi beta-lactamase family protein 0.0187 0.0461 0.1097
Plasmodium falciparum protein kinase 5 0.0053 0.01 0.0091
Loa Loa (eye worm) hypothetical protein 0.0049 0.0088 0.0191
Trichomonas vaginalis glutamate synthase, putative 0.0022 0.0014 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0049 0.0717
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Treponema pallidum oxidoreductase 0.0022 0.0014 0.0006
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0034 0.0049 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0027 0.0329
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0081 0.0174 0.2138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0075 0.0162
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0081 0.0175 0.0167
Trichomonas vaginalis cyclin A, putative 0.0064 0.0129 0.2135
Loa Loa (eye worm) hypothetical protein 0.0034 0.0049 0.0097
Loa Loa (eye worm) hypothetical protein 0.011 0.0252 0.0582
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.0397 0.1179
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0093 0.0203
Treponema pallidum NADH oxidase 0.0081 0.0175 0.0167
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0034 0.0049 0.0519
Trichomonas vaginalis cyclin D, putative 0.0064 0.0129 0.2135
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0014 0.0078
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 0.0034 0.0049 0.0097
Plasmodium vivax ferrodoxin reductase, putative 0.0022 0.0014 0.0006
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.1319 0.3513 0.8361
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0034 0.0049 0.0097
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0009 0.0046
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.01 0.0218
Brugia malayi Ets-domain containing protein 0.0084 0.0183 0.0435
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0076 0.0646
Mycobacterium ulcerans beta-lactamase 0.0187 0.0461 0.0453
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0548
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0034 0.0049 0.0519
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0034 0.0049 0.0097
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Giardia lamblia Cyclin A 0.0064 0.0129 0.7251
Trichomonas vaginalis cyclins, putative 0.0064 0.0129 0.2135
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0117 0.0273 0.0649
Schistosoma mansoni tar DNA-binding protein 0.0276 0.0699 0.165
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0033 0.006
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Treponema pallidum thioredoxin reductase (trxB) 0.0022 0.0014 0.0006
Trichomonas vaginalis cyclin B, putative 0.0064 0.0129 0.2135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0051 0.0758
Brugia malayi ubiquitin specific protease 14 0.0034 0.0049 0.0116
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0081 0.0175 0.2131
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0049 0.0098
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0034 0.0049 0.0099
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0021 0.022
Brugia malayi Nuclear hormone receptor E75 0.0055 0.0105 0.0251
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0081 0.0175 0.2131
Loa Loa (eye worm) hypothetical protein 0.0117 0.0273 0.0631
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0014 0.0107
Loa Loa (eye worm) hypothetical protein 0.0284 0.0722 0.1703
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Echinococcus multilocularis GA binding protein alpha chain 0.0084 0.0183 0.0417
Trypanosoma cruzi cyclin 6, putative 0.0064 0.0129 0.1545
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0074 0.0864
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0276 0.0699 0.1649
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0117 0.0273 0.0631
Plasmodium vivax thioredoxin reductase, putative 0.0235 0.0589 0.0582
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0021 0.0218
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 47 0.0034 0.0049 0.0097
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0034 0.0049 0.0099
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Brugia malayi tailless protein 0.0055 0.0105 0.0251
Echinococcus granulosus peptidase Clp S14 family 0.1031 0.2738 0.6512
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0024 0.0016
Brugia malayi Protein kinase domain containing protein 0.0203 0.0504 0.12
Schistosoma mansoni lamin 0.0284 0.0722 0.1704
Loa Loa (eye worm) programmed cell death 8 0.0022 0.0014 0.0015
Loa Loa (eye worm) hypothetical protein 0.0064 0.0129 0.0289
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0075 0.016
Brugia malayi hypothetical protein 0.0055 0.0105 0.0251
Loa Loa (eye worm) hypothetical protein 0.0064 0.0129 0.0289
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0049 0.0041
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0081 0.0175 0.0418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0117 0.0273 0.0631
Brugia malayi photoreceptor-specific nuclear receptor 0.0117 0.0273 0.0649
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0022 0.0014 0.0006
Onchocerca volvulus Protein ultraspiracle homolog 0.0117 0.0273 0.3652
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0022 0.0014 0.0015
Leishmania major hypothetical protein, conserved 0.0022 0.0014 0.0078
Echinococcus granulosus TGF beta signal transducer SmadC 0.0076 0.0161 0.0364
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis ubiquitin specific protease, putative 0.0034 0.0049 0.0717
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0034 0.0049 0.0519
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0034 0.0049 0.2436
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0034 0.0049 0.0717
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0034 0.0049 0.039
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0009 0.0003

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.54 uM Inhibition of Cyclin-dependent kinase 2 ChEMBL. 15149678
IC50 (binding) = 0.54 uM Inhibition of Cyclin-dependent kinase 2 ChEMBL. 15149678
IC50 (binding) = 0.68 uM Inhibition of Cyclin-dependent kinase 4 ChEMBL. 15149678
IC50 (binding) = 0.68 uM Inhibition of Cyclin-dependent kinase 4 ChEMBL. 15149678
Inhibition (binding) = 19 nM Inhibition of partially purified rat brain protein kinase C ChEMBL. No reference
Inhibition (binding) = 19 nM Inhibition of partially purified rat brain protein kinase C ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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