Detailed information for compound 591653

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 554.593 | Formula: C32H41Cl2N3O
  • H donors: 0 H acceptors: 0 LogP: 7.55 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1ccc(cc1)C(c1ccccc1)N1CCN(CC1)Cc1ccc(cc1)OC1CCN(CC1)C(C)C.Cl
  • InChi: 1S/C32H40ClN3O.ClH/c1-25(2)35-18-16-31(17-19-35)37-30-14-8-26(9-15-30)24-34-20-22-36(23-21-34)32(27-6-4-3-5-7-27)28-10-12-29(33)13-11-28;/h3-15,25,31-32H,16-24H2,1-2H3;1H
  • InChiKey: BEAKYLPUNOCSID-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0169 0.0243 0.6225
Echinococcus multilocularis neuropeptide receptor 0.0206 0.0302 0.0366
Onchocerca volvulus 0.0206 0.0302 0.1097
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0014 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0194 0.0283 0.0283
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0019 0.001 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0059 0.0871
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Onchocerca volvulus Alhambra homolog 0.0018 0.0009 0.0032
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0094 0.0126 1
Echinococcus granulosus sodium:glucose cotransporter 0.0024 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0206 0.0302 0.0353
Brugia malayi FAT domain containing protein 0.0014 0.0001 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0047 0.0053 0.0064
Echinococcus granulosus hypothetical protein 0.55 0.8557 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0047 0.0053 0.0061
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0012 0.0914
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0013 0.0001 0.0001
Brugia malayi G-protein coupled receptor 0.0206 0.0302 0.0302
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0023 0.0028
Echinococcus multilocularis neuropeptide FF receptor 2 0.0206 0.0302 0.0366
Brugia malayi hypothetical protein 0.0183 0.0266 0.0266
Plasmodium vivax glutathione reductase, putative 0.0034 0.0034 0.1111
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0036 0.0043
Schistosoma mansoni inositol transporter 0.0024 0.0018 0.0065
Echinococcus granulosus peptide allatostatin:somatostatin 0.0206 0.0302 0.0353
Entamoeba histolytica hypothetical protein 0.0047 0.0053 0.4141
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0027 0.0098
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0194 0.0283 0.1473
Brugia malayi Pre-SET motif family protein 0.0387 0.0584 0.0584
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0021 0.0013 0.0015
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0206 0.0302 0.1097
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0206 0.0302 0.0353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0206 0.0302 0.1097
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0028 0.0024 0.0027
Giardia lamblia GTOR 0.0094 0.0126 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0008 0.0102
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0018 0.0008 0.0009
Onchocerca volvulus 0.0194 0.0283 0.1027
Onchocerca volvulus 0.0028 0.0023 0.0084
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0169 0.0243 0.0284
Echinococcus granulosus lysine specific demethylase 5A 0.003 0.0027 0.0031
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0019 0.001 0.0011
Echinococcus granulosus voltage gated potassium channel 0.0027 0.0022 0.0026
Schistosoma mansoni hypothetical protein 0.0018 0.0009 0.0032
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0048 0.0056 0.1901
Loa Loa (eye worm) hypothetical protein 0.0027 0.0022 0.0022
Schistosoma mansoni neuropeptide receptor 0.0206 0.0302 0.1097
Onchocerca volvulus 0.0169 0.0243 0.0882
Schistosoma mansoni Smad4 0.0014 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0066 0.0083 0.0083
Brugia malayi Melatonin receptor type 1A 0.0206 0.0302 0.0302
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0012 0.0011
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0206 0.0302 0.1097
Schistosoma mansoni biogenic amine receptor 0.0206 0.0302 0.1097
Schistosoma mansoni nuclear receptor nhr-48 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0489 0.0743 0.0743
Schistosoma mansoni ferritin 0.0014 0.0002 0.0007
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0012 0.006
Brugia malayi Intermediate filament tail domain containing protein 0.0067 0.0085 0.0085
Brugia malayi PHD-finger family protein 0.0018 0.0009 0.0009
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0021 0.0013 0.0012
Schistosoma mansoni jumonji/arid domain-containing protein 0.003 0.0027 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0028 0.0409
Onchocerca volvulus 0.0206 0.0302 0.1097
Echinococcus granulosus glutamate receptor 2 0.0019 0.001 0.0011
Schistosoma mansoni sodium/chloride dependent transporter 0.0246 0.0364 0.1321
Echinococcus granulosus lamin 0.0067 0.0085 0.0099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0028 0.0409
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0206 0.0302 0.1097
Mycobacterium ulcerans lipase LipD 0.0194 0.0283 1
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0023 0.0084
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0031 0.0029 0.0028
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0023 0.0023
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0012 0.0414
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0246 0.0364 0.0363
Schistosoma mansoni intermediate filament proteins 0.0067 0.0085 0.0309
Schistosoma mansoni sodium-dependent amino acid transporter 0.0169 0.0243 0.0882
Echinococcus multilocularis neuropeptide receptor 0.0206 0.0302 0.0366
Echinococcus multilocularis allatostatin A receptor 0.0206 0.0302 0.0366
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0087 0.0116 0.06
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0021 0.0013 0.0012
Echinococcus granulosus raf serine:threonine protein kinase 0.0044 0.0049 0.0057
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0012 0.0914
Trypanosoma cruzi hypothetical protein, conserved 0.0194 0.0283 0.0282
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0194 0.0283 0.1027
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0023 0.0023
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0048 0.0056 0.0286
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0023 0.0084
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Brugia malayi Latrophilin receptor protein 2 0.0164 0.0236 0.0236
Echinococcus multilocularis geminin 0.0916 0.1409 0.1711
Schistosoma mansoni apoferritin-2 0.0014 0.0002 0.0007
Echinococcus granulosus G protein coupled receptor 139 0.0206 0.0302 0.0353
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.0352 0.0528 0.0528
Loa Loa (eye worm) neuropeptide F receptor 0.0206 0.0302 0.0302
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0023 0.0023
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0169 0.0243 0.0284
Trypanosoma cruzi C-8 sterol isomerase, putative 0.6425 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0519 0.0789 0.0789
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0206 0.0302 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0023 0.0023
Echinococcus granulosus neuropeptide s receptor 0.0497 0.0755 0.0882
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0059 0.0869
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0028 0.0409
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0206 0.0302 0.0302
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0078 0.0102 0.0529
Brugia malayi Sodium:solute symporter family protein 0.0024 0.0018 0.0018
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0246 0.0364 0.0364
Loa Loa (eye worm) melatonin receptor type 1A 0.0206 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0164 0.0236 0.0236
Brugia malayi putative neuropeptide receptor NPR1 0.0206 0.0302 0.0302
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0029 0.0025 0.0025
Echinococcus granulosus g protein coupled receptor 0.0206 0.0302 0.0353
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0012 0.2783
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0206 0.0302 0.0366
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0059 0.0869
Brugia malayi Muscleblind-like protein 0.0326 0.0489 0.0489
Loa Loa (eye worm) MH2 domain-containing protein 0.0211 0.0309 0.0309
Schistosoma mansoni cpg binding protein 0.0144 0.0205 0.0743
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0008 0.0028
Schistosoma mansoni adenoreceptor 0.0206 0.0302 0.1097
Schistosoma mansoni terminal deoxycytidyl transferase 0.0013 0.0001 0.0003
Brugia malayi hypothetical protein 0.0206 0.0302 0.0302
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0071 0.0085
Schistosoma mansoni biogenic amine receptor 0.0206 0.0302 0.1097
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0021 0.0013 0.0015
Onchocerca volvulus 0.0194 0.0283 0.1027
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0028 0.0409
Schistosoma mansoni hypothetical protein 0.0164 0.0236 0.0857
Plasmodium vivax hypothetical protein, conserved 0.0169 0.0243 0.8576
Echinococcus multilocularis dna polymerase eta 0.0013 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0206 0.0302 0.1097
Echinococcus granulosus hyperpolarization activated cyclic 0.0021 0.0012 0.0014
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0087 0.0116 0.4048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0019 0.0276
Loa Loa (eye worm) CXXC zinc finger family protein 0.0136 0.0192 0.0192
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0024 0.0018 0.0268
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0023 0.0026
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0194 0.0283 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0169 0.0243 0.0243
Brugia malayi Bromodomain containing protein 0.0018 0.0009 0.0009
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0078 0.0102 0.0529
Brugia malayi steroid hormone receptor 0.0028 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0028 0.0409
Brugia malayi neuropeptide F receptor 0.0206 0.0302 0.0302
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0001 0.0001
Echinococcus multilocularis peregrin 0.0018 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0169 0.0243 0.0243
Echinococcus multilocularis vesicular acetylcholine transporter 0.1778 0.2753 0.3343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0096 0.1431
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0206 0.0302 0.1097
Trypanosoma cruzi target of rapamycin kinase 3 0.0075 0.0096 0.0095
Echinococcus granulosus sodium and chloride dependent glycine 0.0246 0.0364 0.0424
Schistosoma mansoni ap endonuclease 0.0021 0.0012 0.0045
Plasmodium falciparum glutathione reductase 0.0034 0.0034 0.1295
Giardia lamblia PHD finger protein 15 0.0018 0.0009 0.0628
Onchocerca volvulus 0.0206 0.0302 0.1097
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0062 0.0061
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0031 0.0029 0.0035
Schistosoma mansoni 60S ribosomal protein L21 0.0018 0.0008 0.0028
Schistosoma mansoni hypothetical protein 0.0014 0.0001 0.0005
Brugia malayi jmjC domain containing protein 0.006 0.0074 0.0074
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0029 0.0028
Echinococcus granulosus neuropeptide Y receptor 0.0206 0.0302 0.0353
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0027 0.0022 0.0022
Brugia malayi MH2 domain containing protein 0.0014 0.0002 0.0002
Loa Loa (eye worm) norepinephrine transporter 0.0901 0.1386 0.1386
Schistosoma mansoni apoferritin-2 0.0014 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Loa Loa (eye worm) phosphatidylinositol 3 0.0094 0.0126 0.0126
Echinococcus granulosus mothers against decapentaplegic 5 0.0014 0.0002 0.0003
Onchocerca volvulus 0.0013 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0059 0.0871
Echinococcus multilocularis g protein coupled receptor 0.0206 0.0302 0.0366
Schistosoma mansoni hypothetical protein 0.0916 0.1409 0.5119
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0206 0.0302 0.1097
Echinococcus multilocularis G-protein coupled receptor, putative 0.0206 0.0302 0.0366
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0021 0.0013 0.0046
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0023 0.0023
Brugia malayi latrophilin 2 splice variant baaae 0.0355 0.0533 0.0533
Loa Loa (eye worm) Smad1 0.0014 0.0002 0.0002
Echinococcus multilocularis conserved hypothetical protein 0.5293 0.8235 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0206 0.0302 0.0302
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0029 0.0029
Loa Loa (eye worm) MH2 domain-containing protein 0.0014 0.0002 0.0002
Onchocerca volvulus Glucosylceramidase homolog 0.0118 0.0165 0.0599
Echinococcus multilocularis serotonin receptor 0.0573 0.0874 0.1061
Echinococcus multilocularis G protein coupled receptor 139 0.0206 0.0302 0.0366
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0024 0.0018 0.002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0169 0.0243 0.0882
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0194 0.0283 0.0283
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.012 0.0168 0.0196
Loa Loa (eye worm) transcription factor SMAD2 0.0211 0.0309 0.0309
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0044 0.0049 0.0059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0206 0.0302 0.0366
Echinococcus multilocularis g protein coupled receptor 0.0206 0.0302 0.0366
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0023 0.0084
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0028 0.0409
Echinococcus granulosus GA binding protein alpha chain 0.0046 0.0052 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0075 0.111
Echinococcus multilocularis musashi 0.0067 0.0085 0.0103
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0012 0.0168
Loa Loa (eye worm) hypothetical protein 0.0068 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0066 0.0984
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0206 0.0302 0.0302
Brugia malayi small heat shock protein 0.0352 0.0528 0.0528
Schistosoma mansoni myosin xvIII 0.0206 0.0302 0.1097
Schistosoma mansoni smad1 5 8 and 0.0014 0.0002 0.0009
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0039 0.0045
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0019 0.001 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0206 0.0302 0.0353
Loa Loa (eye worm) histone methyltransferase 0.0044 0.0049 0.0049
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0003 0.001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0028 0.0409
Brugia malayi hypothetical protein 0.0206 0.0302 0.0302
Brugia malayi hypothetical protein 0.0206 0.0302 0.0302
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0094 0.0126 0.0458
Brugia malayi intermediate filament protein 0.0067 0.0085 0.0085
Toxoplasma gondii endonuclease IV APN 0.0048 0.0056 0.127
Loa Loa (eye worm) hypothetical protein 0.0194 0.0283 0.0283
Brugia malayi nuclear hormone receptor 0.0028 0.0023 0.0023
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0031 0.0029 0.0034
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0074 0.0086
Echinococcus granulosus sodium and chloride dependent glycine 0.0246 0.0364 0.0424
Echinococcus granulosus dnaJ subfamily B 0.0964 0.1484 0.1734
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0023 0.0023
Schistosoma mansoni neuropeptide receptor 0.0206 0.0302 0.1097
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0032 0.003 0.0153
Loa Loa (eye worm) latrophilin receptor protein 2 0.0164 0.0236 0.0236
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0206 0.0302 0.0366
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0169 0.0243 0.0882
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0048 0.0056 0.2216
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Leishmania major trypanothione reductase 0.0034 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.024 0.0354 0.0354
Onchocerca volvulus 0.0169 0.0243 0.0882
Brugia malayi nuclear receptor NHR-88 0.0028 0.0023 0.0023
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0206 0.0302 0.0302
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0021 0.0013 0.0061
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0023 0.0084
Echinococcus multilocularis thioredoxin glutathione reductase 0.0034 0.0034 0.004
Echinococcus multilocularis lamin dm0 0.0067 0.0085 0.0103
Echinococcus multilocularis fmrfamide receptor 0.0206 0.0302 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Mycobacterium tuberculosis Probable dehydrogenase 0.0078 0.0102 0.0529
Toxoplasma gondii PHD-finger domain-containing protein 0.0018 0.0009 0.0028
Echinococcus multilocularis g protein coupled receptor 0.0206 0.0302 0.0366
Echinococcus multilocularis smad 0.0014 0.0002 0.0003
Onchocerca volvulus 0.0194 0.0283 0.1027
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0024 0.0018 0.0021
Onchocerca volvulus 0.0136 0.0192 0.0699
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0078 0.0102 0.0529
Schistosoma mansoni growth hormone secretagogue receptor 0.0206 0.0302 0.1097
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0023 0.0026
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0062 0.0061
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0206 0.0302 0.1097
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0078 0.0101 0.0101
Onchocerca volvulus 0.0206 0.0302 0.1097
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0003 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0125 0.0175 0.261
Plasmodium falciparum amino acid transporter, putative 0.0169 0.0243 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0071 0.0257
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0023 0.0028
Brugia malayi hypothetical protein 0.0206 0.0302 0.0302
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0169 0.0243 0.0882
Schistosoma mansoni neuropeptide f receptor 76f 0.0206 0.0302 0.1097
Echinococcus multilocularis rhodopsin orphan GPCR 0.0206 0.0302 0.0366
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0181 0.0262 0.0261
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0206 0.0302 0.1097
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0029 0.0423
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0021 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0018 0.0008 0.0543
Trichomonas vaginalis esterase, putative 0.0194 0.0283 0.4232
Mycobacterium tuberculosis Probable lipase LipE 0.0194 0.0283 0.1473
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0021 0.0012 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0194 0.0283 1
Mycobacterium ulcerans hypothetical protein 0.0194 0.0283 1
Echinococcus granulosus ferritin 0.0014 0.0002 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0206 0.0302 0.0366
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0014 0.0002 0.0006
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0206 0.0302 0.0366
Echinococcus granulosus peregrin 0.0018 0.0009 0.001
Plasmodium falciparum transporter, putative 0.0169 0.0243 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0028 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.0519 0.0789 0.0789
Toxoplasma gondii PHD-finger domain-containing protein 0.0018 0.0009 0.0028
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0014 0.0002 0.0009
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0021 0.0012 0.0012
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.0188 0.0188
Schistosoma mansoni myst-related protein 0.0016 0.0005 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0023 0.0023
Onchocerca volvulus 0.0067 0.0085 0.0309
Leishmania major cytochrome p450-like protein 0.0014 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0023 0.0023
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0029 0.0028
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0078 0.0102 0.3563
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0206 0.0302 0.1097
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0023 0.0084
Brugia malayi G protein-coupled receptor 0.0206 0.0302 0.0302
Schistosoma mansoni biogenic amine (5HT) receptor 0.0573 0.0874 0.3174
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0262 0.3914
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0028 0.0409
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0049 0.0048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0021 0.0013 0.0015
Echinococcus granulosus dna polymerase eta 0.0013 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0229 0.0337 0.5045
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0165 0.246
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0013 0.0001 0.0003
Echinococcus multilocularis bloom syndrome protein 0.0013 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.0206 0.0302 0.1097
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0096 0.1431
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0262 0.3914
Brugia malayi Bloom's syndrome protein homolog 0.0013 0.0001 0.0001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0194 0.0283 0.0343
Echinococcus multilocularis PHD finger protein rhinoceros 0.0018 0.0009 0.001
Plasmodium falciparum thioredoxin reductase 0.0034 0.0034 0.1295
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0029 0.0423
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0019 0.001 0.0011
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0031 0.0029 0.0028
Echinococcus granulosus fmrfamide receptor 0.0206 0.0302 0.0353
Loa Loa (eye worm) hypothetical protein 0.0219 0.0322 0.0322
Schistosoma mansoni neuropeptide F-like receptor 0.0206 0.0302 0.1097
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1634 0.2528 0.307
Trichomonas vaginalis penicillin-binding protein, putative 0.0194 0.0283 0.4232
Trichomonas vaginalis glucosylceramidase, putative 0.0125 0.0175 0.261
Echinococcus granulosus 7tm_1 domain containing protein 0.0206 0.0302 0.0353
Schistosoma mansoni survival motor neuron protein 0.0037 0.0038 0.0139
Schistosoma mansoni opsin-like receptor 0.0206 0.0302 0.1097
Echinococcus granulosus microtubule associated protein 2 0.0435 0.0659 0.077
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0094 0.0126 0.0153
Trypanosoma brucei ISWI complex protein 0.0014 0.0002 0.0001
Echinococcus granulosus g protein coupled receptor 0.0206 0.0302 0.0353
Echinococcus multilocularis microtubule associated protein 2 0.0435 0.0659 0.08
Brugia malayi hypothetical protein 0.0052 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Echinococcus granulosus neuropeptide receptor A26 0.0497 0.0755 0.0882
Onchocerca volvulus 0.0206 0.0302 0.1097
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0021 0.0013 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0096 0.1431
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0206 0.0302 0.0366
Loa Loa (eye worm) hypothetical protein 0.6425 1 1
Brugia malayi CXXC zinc finger family protein 0.0136 0.0192 0.0192
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0206 0.0302 0.1097
Loa Loa (eye worm) inositol-1 0.0038 0.0039 0.0039
Brugia malayi Serotonin receptor 0.0206 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0011
Onchocerca volvulus 0.0024 0.0018 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0089 0.1318
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0021 0.0013 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0194 0.0283 0.4232
Trypanosoma cruzi hypothetical protein, conserved 0.0194 0.0283 0.0282
Brugia malayi Dopamine receptor 0.0206 0.0302 0.0302
Loa Loa (eye worm) G-protein coupled receptor 0.0206 0.0302 0.0302
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.0169 0.0243 0.0243
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0003 0.0003
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0045 0.005 0.006
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0094 0.0126 0.0125
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0006 0.0075
Loa Loa (eye worm) hypothetical protein 0.0169 0.0243 0.0243
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0169 0.0243 0.0243
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0067 0.0084 0.1246
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0023 0.0084
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Echinococcus granulosus neuropeptides capa receptor 0.0206 0.0302 0.0353
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0039 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Loa Loa (eye worm) thioredoxin reductase 0.0034 0.0034 0.0033
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0039 0.0038
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0206 0.0302 0.0353
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0018 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0002
Schistosoma mansoni high-affinity choline transporter 0.0219 0.0322 0.117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0067 0.0997
Echinococcus granulosus smad 0.0014 0.0002 0.0003
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0078 0.0102 0.0529
Loa Loa (eye worm) hypothetical protein 0.0169 0.0243 0.0243
Onchocerca volvulus 0.0206 0.0302 0.1097
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0078 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0326 0.0489 0.0488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0029 0.0423
Brugia malayi nuclear receptor RXR 0.0015 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0089 0.1318
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0012 0.0075
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0012 0.0406
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0062 0.2459
Schistosoma mansoni neuropeptide receptor 0.0206 0.0302 0.1097
Mycobacterium tuberculosis Probable esterase LipL 0.0194 0.0283 0.1473
Schistosoma mansoni opsin-like receptor 0.0206 0.0302 0.1097
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0094 0.0126 0.0125
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0023 0.0026
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0014 0.0002 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0042 0.0045 0.0165
Loa Loa (eye worm) hypothetical protein 0.0246 0.0364 0.0363
Loa Loa (eye worm) hypothetical protein 0.0052 0.0062 0.0061
Trichomonas vaginalis D-aminoacylase, putative 0.0194 0.0283 0.4232
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0029 0.0025 0.0029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0047 0.0053 0.4141
Schistosoma mansoni hypothetical protein 0.0355 0.0533 0.1936
Schistosoma mansoni ferritin light chain 0.0014 0.0002 0.0007
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0001 0.0003
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0032 0.003 0.1035
Brugia malayi MH2 domain containing protein 0.0211 0.0309 0.0309
Echinococcus granulosus serotonin transporter 0.0901 0.1386 0.1619
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0262 0.3914
Schistosoma mansoni jumonji domain containing protein 0.0048 0.0055 0.0199
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0012 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0009 0.0227
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0012 0.0044
Brugia malayi AKH receptor 0.0206 0.0302 0.0302
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0206 0.0302 0.0302
Echinococcus granulosus mixed lineage leukemia protein mll 0.0036 0.0036 0.0042
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0206 0.0302 0.1097
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0008 0.0008
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0039 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0096 0.1431
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0002 0.0002
Schistosoma mansoni gabp alpha 0.0046 0.0052 0.0187
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0034 0.0034 0.0171
Toxoplasma gondii hypothetical protein 0.0169 0.0243 0.6225
Echinococcus multilocularis sex peptide receptor 0.0206 0.0302 0.0366
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0039 0.0574
Echinococcus multilocularis somatostatin receptor 0.0206 0.0302 0.0366
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0027 0.0022 0.0022
Echinococcus granulosus sex peptide receptor 0.0206 0.0302 0.0353
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Echinococcus granulosus allatostatin A receptor 0.0206 0.0302 0.0353
Brugia malayi hypothetical protein 0.0015 0.0003 0.0003
Loa Loa (eye worm) intermediate filament protein 0.0067 0.0085 0.0085
Echinococcus granulosus rhodopsin orphan GPCR 0.0206 0.0302 0.0353
Brugia malayi hypothetical protein 0.0047 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0023 0.0017 0.006
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0021 0.0013 0.0012
Mycobacterium ulcerans esterase/lipase LipP 0.0194 0.0283 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0071 0.0082
Echinococcus granulosus biogenic amine 5HT receptor 0.0206 0.0302 0.0353
Schistosoma mansoni lipoxygenase 0.0028 0.0024 0.0086
Schistosoma mansoni smad 0.0014 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0028
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0023 0.0028
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0023 0.0084
Echinococcus multilocularis hyperpolarization activated cyclic 0.0021 0.0012 0.0014
Trichomonas vaginalis DNA helicase recq1, putative 0.0013 0.0001 0.0003
Loa Loa (eye worm) fli-1 protein 0.0139 0.0197 0.0197
Leishmania major hypothetical protein, conserved 0.0052 0.0062 0.0061
Brugia malayi MH1 domain containing protein 0.0014 0.0002 0.0002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0194 0.0283 1
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0165 0.246
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0023 0.0026
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0032 0.0031 0.0037
Schistosoma mansoni neuropeptide receptor 0.0206 0.0302 0.1097
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0002 0.0002
Brugia malayi vesicular acetylcholine transporter unc-17 0.1778 0.2753 0.2753
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0094 0.0126 0.0147
Mycobacterium leprae conserved hypothetical protein 0.0194 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0012
Loa Loa (eye worm) solute carrier family 6 member 4 0.0901 0.1386 0.1386
Leishmania major hypothetical protein, conserved 0.0194 0.0283 0.0282
Echinococcus multilocularis neuropeptide receptor A26 0.0497 0.0755 0.0916
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0089 0.1318
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0094 0.0126 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0002 0.0022
Schistosoma mansoni ferritin 0.0014 0.0002 0.0007
Toxoplasma gondii ABC1 family protein 0.0194 0.0283 0.7282
Echinococcus granulosus tachykinin peptides receptor 99D 0.0206 0.0302 0.0353
Toxoplasma gondii hypothetical protein 0.0169 0.0243 0.6225
Echinococcus granulosus tm gpcr rhodopsin 0.2304 0.3574 0.4176
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0017
Treponema pallidum sodium- and chloride- dependent transporter 0.0901 0.1386 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0206 0.0302 0.1097
Loa Loa (eye worm) hypothetical protein 0.0048 0.0056 0.0055
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0206 0.0302 0.1097
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0029 0.0028
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0029 0.0029
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0169 0.0243 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0036 0.0042
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0048 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0002
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0018 0.0009 0.0032
Brugia malayi cytoplasmic intermediate filament protein 0.0036 0.0036 0.0036
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0032 0.003 0.0203
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0206 0.0302 0.1097
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0062 0.1425
Loa Loa (eye worm) hypothetical protein 0.0901 0.1386 0.1386
Entamoeba histolytica hypothetical protein 0.0018 0.0008 0.0543
Onchocerca volvulus 0.0441 0.0667 0.2423
Schistosoma mansoni hypothetical protein 0.0047 0.0053 0.0192
Chlamydia trachomatis endonuclease IV 0.0048 0.0056 0.1203
Loa Loa (eye worm) RecQ helicase 0.0013 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0206 0.0302 0.1097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0071 0.0257
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0019 0.001 0.0011
Schistosoma mansoni hypothetical protein 0.0037 0.0038 0.0139
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0169 0.0243 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0028 0.0409
Loa Loa (eye worm) PHD-finger family protein 0.0018 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0041 0.0041
Echinococcus granulosus neuropeptides capa receptor 0.0206 0.0302 0.0353
Schistosoma mansoni vesicular acetylcholine transporter 0.1778 0.2753 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0021 0.0013 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0165 0.246
Brugia malayi hypothetical protein 0.0206 0.0302 0.0302
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0206 0.0302 0.1097
Echinococcus granulosus solute carrier family 5 0.0024 0.0018 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0206 0.0302 0.1097
Toxoplasma gondii thioredoxin reductase 0.0034 0.0034 0.0684
Schistosoma mansoni coup transcription factor 0.0028 0.0023 0.0084
Trichomonas vaginalis hypothetical protein 0.0017 0.0006 0.0075
Schistosoma mansoni glutamate receptor NMDA 0.0019 0.001 0.0035
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0023 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0089 0.1318
Echinococcus multilocularis neuropeptide Y receptor 0.0206 0.0302 0.0366
Brugia malayi hypothetical protein 0.0034 0.0033 0.0033
Mycobacterium ulcerans endonuclease IV 0.0048 0.0056 0.1944
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0028 0.0409
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.012 0.0168 0.0609
Echinococcus granulosus high affinity choline transporter 1 0.0219 0.0322 0.0376
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0027 0.0022 0.0027
Brugia malayi beta-lactamase family protein 0.0194 0.0283 0.0283
Loa Loa (eye worm) serotonin transporter b 0.0901 0.1386 0.1386
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0008 0.0102
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0014 0.005
Echinococcus multilocularis sodium and chloride dependent glycine 0.0246 0.0364 0.0441
Schistosoma mansoni inositol transporter 0.0024 0.0018 0.0065
Echinococcus granulosus dna polymerase kappa 0.0013 0.0001 0.0001
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0169 0.0243 0.0882
Onchocerca volvulus 0.0067 0.0085 0.0309
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0169 0.0243 0.0295
Echinococcus multilocularis lysine specific demethylase 5A 0.0022 0.0015 0.0018
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0901 0.1386 0.5034
Loa Loa (eye worm) hypothetical protein 0.0489 0.0743 0.0743
Mycobacterium tuberculosis Probable oxidoreductase 0.0087 0.0116 0.06
Brugia malayi Tachykinin-like peptides receptor 99D 0.0206 0.0302 0.0302
Schistosoma mansoni hypothetical protein 0.0206 0.0302 0.1097
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0165 0.246
Echinococcus granulosus neuropeptide FF receptor 2 0.0206 0.0302 0.0353
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0033 0.0168
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2304 0.3574 0.434
Echinococcus granulosus intermediate filament protein 0.0067 0.0085 0.0099
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0002
Echinococcus granulosus PHD finger protein rhinoceros 0.0018 0.0009 0.001
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0206 0.0302 0.0302
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0094 0.0126 0.0125
Echinococcus multilocularis serotonin transporter 0.0901 0.1386 0.1683
Schistosoma mansoni amine GPCR 0.0327 0.0491 0.1782
Brugia malayi GH02984p 0.0219 0.0322 0.0322
Brugia malayi hypothetical protein 0.0169 0.0243 0.0243
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0036 0.0036 0.0036
Onchocerca volvulus Neuropeptide F receptor homolog 0.0206 0.0302 0.1097
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0169 0.0243 0.0882
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0039 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0028 0.0409
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0094 0.0126 0.0125
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0164 0.0236 0.0286
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013 0 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0206 0.0302 0.1097
Mycobacterium tuberculosis Conserved protein 0.0194 0.0283 0.1473
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0013 0.0001 0.0001
Loa Loa (eye worm) beta-lactamase 0.0194 0.0283 0.0283
Echinococcus granulosus geminin 0.0916 0.1409 0.1647
Echinococcus granulosus orexin receptor type 2 0.0206 0.0302 0.0353
Schistosoma mansoni smad1 5 8 and 0.0014 0.0002 0.0009
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0023 0.0026
Onchocerca volvulus 0.0037 0.0038 0.0139
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0044 0.0049 0.0057
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0012 0.0014
Schistosoma mansoni voltage-gated potassium channel 0.0021 0.0012 0.0044
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.1778 0.2753 1
Echinococcus granulosus somatostatin receptor 0.0206 0.0302 0.0353
Echinococcus granulosus neuropeptide receptor 0.0206 0.0302 0.0353
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0024 0.0018 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0262 0.3914
Echinococcus multilocularis rhodopsin orphan GPCR 0.0206 0.0302 0.0366
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0018 0.0008 0.0007
Schistosoma mansoni histamine h1 receptor 0.0206 0.0302 0.1097
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.0573 0.0874 0.0874
Schistosoma mansoni nuclear hormone receptor 0.0013 0 0.0001
Echinococcus granulosus biogenic amine 5HT receptor 0.0573 0.0874 0.1021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0028 0.0409
Loa Loa (eye worm) hypothetical protein 0.0183 0.0266 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0089 0.1318
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0169 0.0243 0.6225
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.0188 0.0188
Schistosoma mansoni amine GPCR 0.0206 0.0302 0.1097
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0169 0.0243 0.0284
Onchocerca volvulus 0.0206 0.0302 0.1097
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0206 0.0302 0.0353
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0023 0.0023
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0046 0.0052 0.0051
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0021 0.0012 0.0014
Brugia malayi Dopamine receptor protein 1 0.0206 0.0302 0.0302
Echinococcus granulosus neuropeptide Y receptor 0.0206 0.0302 0.0353
Toxoplasma gondii non-specific serine/threonine protein kinase 0.002 0.0011 0.0084
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0021 0.0012 0.0044
Onchocerca volvulus 0.0206 0.0302 0.1097
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0164 0.0236 0.0286
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.012 0.0168 0.0203
Schistosoma mansoni cpg binding protein 0.0144 0.0205 0.0743
Echinococcus granulosus lamin dm0 0.0067 0.0085 0.0099
Brugia malayi MH1 domain containing protein 0.0014 0.0002 0.0002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0206 0.0302 0.0366
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.012 0.0168 0.0609
Onchocerca volvulus 0.0206 0.0302 0.1097
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Echinococcus multilocularis rhodopsin orphan GPCR 0.0206 0.0302 0.0366
Echinococcus multilocularis rhodopsin orphan GPCR 0.0206 0.0302 0.0366
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0021 0.0013 0.0362
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0206 0.0302 0.0366
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0039 0.3055
Loa Loa (eye worm) hypothetical protein 0.0246 0.0364 0.0363
Schistosoma mansoni biogenic amine receptor 0.0206 0.0302 0.1097
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0008 0.0007
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0194 0.0283 0.1473
Schistosoma mansoni hypothetical protein 0.0916 0.1409 0.5119
Loa Loa (eye worm) hypothetical protein 0.0573 0.0874 0.0874
Echinococcus multilocularis nmda type glutamate receptor 0.0045 0.005 0.006
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0014 0.0001 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0062 0.2459
Echinococcus granulosus g-protein coupled receptor 0.0206 0.0302 0.0353
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0039 0.1357
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0206 0.0302 0.0302
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0017 0.0019
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0023 0.0084
Echinococcus granulosus hyperpolarization activated cyclic 0.0021 0.0012 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0096 0.1431
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0049 0.0178
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0024 0.0018 0.0021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0012 0.0011
Plasmodium falciparum phd finger protein, putative 0.0018 0.0009 0.0265
Onchocerca volvulus 0.0058 0.0071 0.0257
Schistosoma mansoni amine GPCR 0.0206 0.0302 0.1097
Schistosoma mansoni nuclear receptor 0.0013 0 0.0001
Trichomonas vaginalis ferritin, putative 0.0014 0.0002 0.0017
Echinococcus multilocularis orexin receptor type 2 0.0206 0.0302 0.0366
Brugia malayi Cytochrome P450 family protein 0.0014 0.0002 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0165 0.246
Schistosoma mansoni hypothetical protein 0.0964 0.1484 0.539
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0023 0.0026
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0028
Echinococcus granulosus sodium:myo inositol cotransporter 0.0024 0.0018 0.002
Brugia malayi ImpB/MucB/SamB family protein 0.0013 0.0001 0.0001
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0018 0.0008 0.0028
Schistosoma mansoni amine GPCR 0.0206 0.0302 0.1097
Toxoplasma gondii exonuclease III APE 0.0021 0.0012 0.0123
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0003 0.0003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0164 0.0236 0.0275
Loa Loa (eye worm) hypothetical protein 0.0058 0.0071 0.007
Schistosoma mansoni nuclear receptor 0.0013 0 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0023 0.0084
Schistosoma mansoni ferritin light chain 0.0014 0.0002 0.0007
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0039 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0023 0.0023
Echinococcus granulosus nmda type glutamate receptor 0.0045 0.005 0.0058
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0023 0.0026
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0029 0.0025 0.0128
Schistosoma mansoni inositol monophosphatase 0.0038 0.0039 0.0142
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Brugia malayi Ets-domain containing protein 0.0046 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0194 0.0283 0.0283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0067 0.0997
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0089 0.1318
Echinococcus granulosus neuropeptide receptor 0.0206 0.0302 0.0353
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0062 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0059 0.0871
Schistosoma mansoni biogenic amine (5HT) receptor 0.0206 0.0302 0.1097
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.024 0.0354 0.0354
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0034 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0008 0.0102
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0027 0.0022 0.0026
Schistosoma mansoni sodium/solute symporter 0.0024 0.0018 0.0065
Onchocerca volvulus 0.0206 0.0302 0.1097
Echinococcus granulosus beta LACTamase domain containing family member 0.0194 0.0283 0.033
Brugia malayi larval opioid receptor 0.0206 0.0302 0.0302
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0032 0.003 0.0203
Brugia malayi Ets-domain containing protein 0.0046 0.0052 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0023 0.0026
Brugia malayi ecdysteroid receptor 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0105 0.1559
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0014 0.0002 0.0055
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0206 0.0302 0.0353
Brugia malayi TAR-binding protein 0.0134 0.0188 0.0188
Echinococcus multilocularis dna polymerase kappa 0.0013 0.0001 0.0001
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0017 0.002
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0059 0.0869
Onchocerca volvulus 0.0206 0.0302 0.1097
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0039 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0089 0.1318
Schistosoma mansoni lamin 0.0067 0.0085 0.0309
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0012 0.0355
Schistosoma mansoni myst-related protein 0.0016 0.0005 0.0019
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0901 0.1386 0.1386
Onchocerca volvulus 0.0206 0.0302 0.1097
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0188 0.0684
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0206 0.0302 0.0366
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0062 0.2109
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0023 0.0028
Echinococcus multilocularis isocitrate dehydrogenase 0.0021 0.0013 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0194 0.0283 0.0282
Plasmodium vivax SET domain protein, putative 0.0058 0.0071 0.2436
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0022 0.0081
Onchocerca volvulus 0.0901 0.1386 0.5034
Echinococcus granulosus bloom syndrome protein 0.0013 0.0001 0.0001
Loa Loa (eye worm) G-protein coupled receptor 0.0206 0.0302 0.0302
Echinococcus multilocularis lamin 0.0067 0.0085 0.0103
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0012 0.0172
Trichomonas vaginalis set domain proteins, putative 0.0441 0.0667 1
Echinococcus multilocularis neuropeptides capa receptor 0.0206 0.0302 0.0366
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0012 0.0011
Schistosoma mansoni microtubule-associated protein tau 0.0435 0.0659 0.2395
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0037 0.0038 0.0038
Echinococcus multilocularis neuropeptide Y receptor 0.0206 0.0302 0.0366
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0039 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0206 0.0302 0.0353
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0039 0.0047
Echinococcus multilocularis expressed protein 0.0014 0.0002 0.0002
Echinococcus multilocularis Smad4 0.0014 0.0002 0.0003
Echinococcus multilocularis g-protein coupled receptor 0.0206 0.0302 0.0366
Loa Loa (eye worm) glutathione reductase 0.0034 0.0034 0.0033
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0094 0.0126 0.0125
Echinococcus granulosus 7TM GPCR rhodopsin 0.0206 0.0302 0.0353
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0023 0.0028
Schistosoma mansoni smad1 5 8 and 0.0014 0.0002 0.0009
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0067 0.0085 0.0085
Schistosoma mansoni alpha-1 adrenergic receptor 0.0206 0.0302 0.1097
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0028 0.0409
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0023 0.0023
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.1778 0.2753 0.2753
Onchocerca volvulus 0.0206 0.0302 0.1097
Echinococcus multilocularis mothers against decapentaplegic 5 0.0014 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0194 0.0283 0.0283
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.012 0.0168 0.0167
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0188 0.0684
Brugia malayi G-protein coupled receptor 0.0206 0.0302 0.0302
Entamoeba histolytica protein kinase rad3, putative 0.0018 0.0008 0.0543
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0075 0.0096 0.0095
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0023 0.0026
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Brugia malayi Calcitonin receptor-like protein seb-1 0.0519 0.0789 0.0789
Echinococcus multilocularis raf serine:threonine protein kinase 0.0044 0.0049 0.0059
Brugia malayi Raf kinase 0.0044 0.0049 0.0049
Echinococcus granulosus alpha 1A adrenergic receptor 0.0206 0.0302 0.0353
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0012 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0206 0.0302 0.0366
Leishmania major C-8 sterol isomerase-like protein 0.6425 1 1
Echinococcus granulosus cpg binding protein 0.0144 0.0205 0.0239
Schistosoma mansoni voltage-gated potassium channel 0.0084 0.0112 0.0405
Echinococcus multilocularis serotonin receptor 0.0573 0.0874 0.1061
Brugia malayi GnHR receptor homolog 0.0206 0.0302 0.0302
Mycobacterium tuberculosis Probable reductase 0.0078 0.0102 0.0529
Brugia malayi Pre-SET motif family protein 0.0058 0.0071 0.0071
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0031 0.0029 0.0106
Loa Loa (eye worm) hypothetical protein 0.0032 0.0031 0.003
Echinococcus multilocularis tar DNA binding protein 0.0134 0.0188 0.0228
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0206 0.0302 0.1097
Schistosoma mansoni inositol monophosphatase 0.0038 0.0039 0.0142
Brugia malayi follicle stimulating hormone receptor 0.0206 0.0302 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0023 0.0023
Echinococcus multilocularis voltage gated potassium channel 0.0027 0.0022 0.0027
Brugia malayi hypothetical protein 0.0206 0.0302 0.0302
Brugia malayi isocitrate dehydrogenase 0.0021 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0126 0.188
Echinococcus multilocularis hyperpolarization activated cyclic 0.0021 0.0012 0.0014
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0021 0.0012 0.0014
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0169 0.0243 0.0284
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0169 0.0243 0.0243
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0169 0.0243 0.0882
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0262 0.3914
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0023 0.0023
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0078 0.0101 0.0123
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0039 0.0574
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.012 0.0168 0.0609
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0021 0.0012 0.0168
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0003 0.0003
Brugia malayi Fli-1 protein 0.0139 0.0197 0.0197
Echinococcus multilocularis muscleblind protein 1 0.0326 0.0489 0.0593
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0029 0.0025 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0206 0.0302 0.1097
Echinococcus multilocularis neuropeptide s receptor 0.0497 0.0755 0.0916
Echinococcus granulosus rhodopsin orphan GPCR 0.0206 0.0302 0.0353
Onchocerca volvulus 0.0206 0.0302 0.1097
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0022 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0067 0.0997
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0006 0.0075
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0036 0.0036 0.0043
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0012 0.0011
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0023 0.0084
Echinococcus multilocularis ferritin 0.0014 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0028 0.0409
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0071 0.1668
Onchocerca volvulus 0.0206 0.0302 0.1097
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0013 0 0.0001
Schistosoma mansoni neuropeptide F-like receptor 0.0206 0.0302 0.1097
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0094 0.0126 0.0126
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0901 0.1386 0.1386
Onchocerca volvulus 0.0013 0 0.0001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0029 0.0025 0.0869
Brugia malayi hypothetical protein 0.0206 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0029
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0019 0.001 0.0011
Mycobacterium ulcerans bacterioferritin BfrB 0.0014 0.0002 0.0039
Brugia malayi PHD-finger family protein 0.0014 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0029 0.0423
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0028 0.0409
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0039 0.0574
Schistosoma mansoni sodium/chloride dependent transporter 0.0901 0.1386 0.5034
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0165 0.246
Echinococcus granulosus vesicular acetylcholine transporter 0.1778 0.2753 0.3217
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0071 0.0257
Echinococcus granulosus tar DNA binding protein 0.0134 0.0188 0.022
Schistosoma mansoni zinc finger protein 0.0013 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0001
Echinococcus granulosus expressed protein 0.0014 0.0002 0.0002
Echinococcus granulosus tm gpcr rhodopsin 0.0206 0.0302 0.0353
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0029 0.0025 0.0869
Schistosoma mansoni cpg binding protein 0.0136 0.0192 0.0699
Echinococcus granulosus tm gpcr rhodopsin 0.0206 0.0302 0.0353
Toxoplasma gondii histone lysine methyltransferase SET1 0.026 0.0386 1
Loa Loa (eye worm) RNA binding protein 0.0134 0.0188 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0059 0.0871
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.0194 0.0283 0.4232
Loa Loa (eye worm) hypothetical protein 0.0194 0.0283 0.0283
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.012 0.0168 0.0168
Mycobacterium tuberculosis Possible penicillin-binding protein 0.124 0.1914 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0023 0.0084
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0206 0.0302 0.1097
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Echinococcus multilocularis solute carrier family 5 0.0024 0.0018 0.0021
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0206 0.0302 0.0366
Brugia malayi beta-lactamase family protein 0.0194 0.0283 0.0283
Echinococcus granulosus GPCR family 2 0.0164 0.0236 0.0275
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0021 0.0013 0.0422
Echinococcus multilocularis sodium and chloride dependent glycine 0.0246 0.0364 0.0441
Loa Loa (eye worm) TAR-binding protein 0.0134 0.0188 0.0188
Brugia malayi glutathione reductase 0.0034 0.0034 0.0034
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0021 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0206 0.0302 0.0302
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0206 0.0302 0.0366
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0181 0.0262 0.0262
Brugia malayi hypothetical protein 0.0015 0.0003 0.0003
Onchocerca volvulus 0.0206 0.0302 0.1097
Schistosoma mansoni ets-related 0.0139 0.0197 0.0716
Echinococcus granulosus survival motor neuron protein 1 0.0183 0.0266 0.031
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Plasmodium falciparum zinc finger protein, putative 0.0016 0.0005 0.0113
Trichomonas vaginalis D-aminoacylase, putative 0.0194 0.0283 0.4232
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0188 0.0684
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.012 0.0168 0.0203
Mycobacterium tuberculosis Probable hydrolase 0.0194 0.0283 0.1473
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0028 0.0409
Echinococcus granulosus rhodopsin orphan GPCR 0.0206 0.0302 0.0353
Echinococcus multilocularis muscleblind protein 0.0326 0.0489 0.0593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0126 0.188
Mycobacterium ulcerans bacterioferritin BfrA 0.0014 0.0002 0.0039
Echinococcus multilocularis high affinity choline transporter 1 0.0219 0.0322 0.0391
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0074 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0206 0.0302 0.0366
Brugia malayi Cytochrome P450 family protein 0.0014 0.0002 0.0002
Echinococcus granulosus serine protein kinase ATM 0.0018 0.0008 0.0009
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0003 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0023 0.0023
Brugia malayi neuropeptide F receptor 0.0206 0.0302 0.0302
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0169 0.0243 0.0243
Brugia malayi F/Y-rich N-terminus family protein 0.005 0.0057 0.0057
Brugia malayi Cyclic-nucleotide gated cation channel 0.0021 0.0012 0.0012
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0169 0.0243 0.0882
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0014 0.0002 0.0003
Entamoeba histolytica hypothetical protein 0.0047 0.0053 0.4141
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.012 0.0168 0.0196
Schistosoma mansoni hypothetical protein 0.0206 0.0302 0.1097
Schistosoma mansoni ap endonuclease 0.0021 0.0012 0.0045
Echinococcus multilocularis neuropeptides capa receptor 0.0206 0.0302 0.0366
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0206 0.0302 0.0353
Schistosoma mansoni transcription factor LCR-F1 0.0047 0.0053 0.0192
Brugia malayi Dopamine receptor protein 2 0.0206 0.0302 0.0302
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0053 0.0063 0.0073
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0018 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0194 0.0283 0.1473
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0387 0.0584 0.0584
Echinococcus multilocularis serine protein kinase ATM 0.0018 0.0008 0.0009
Plasmodium vivax thioredoxin reductase, putative 0.0034 0.0034 0.1111
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0206 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Schistosoma mansoni hypothetical protein 0.0164 0.0236 0.0857
Loa Loa (eye worm) isocitrate dehydrogenase 0.0021 0.0013 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0078 0.1158
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0002 0.0002
Brugia malayi G protein-coupled receptor F59B2.13 0.0206 0.0302 0.0302
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0019 0.001 0.0011
Echinococcus granulosus muscleblind protein 0.0326 0.0489 0.0571
Echinococcus granulosus rhodopsin orphan GPCR 0.0206 0.0302 0.0353
Brugia malayi beta-lactamase 0.0194 0.0283 0.0283
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0519 0.0789 0.0789
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0071 0.0085
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0023 0.0023
Brugia malayi sulfakinin receptor protein 0.0206 0.0302 0.0302
Brugia malayi hypothetical protein 0.0206 0.0302 0.0302
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0206 0.0302 0.0366
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0023 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0029 0.0423
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0028 0.0409
Echinococcus multilocularis jumonji domain containing protein 0.0026 0.002 0.0024
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0039 0.0833
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0023 0.0084
Echinococcus granulosus Smad4 0.0014 0.0002 0.0003
Brugia malayi RE15519p 0.0206 0.0302 0.0302
Echinococcus multilocularis dro:myosuppressin receptor 0.0206 0.0302 0.0366
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0164 0.0236 0.0275
Brugia malayi ImpB/MucB/SamB family protein 0.0013 0.0001 0.0001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0206 0.0302 0.1097
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0029 0.0025 0.003
Schistosoma mansoni fkbp-rapamycin associated protein 0.0018 0.0008 0.0028
Echinococcus granulosus g protein coupled receptor 0.0206 0.0302 0.0353
Echinococcus granulosus TGF beta signal transducer SmadC 0.0014 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Mycobacterium tuberculosis Probable lipase LipD 0.0194 0.0283 0.1473
Echinococcus multilocularis rhodopsin orphan GPCR 0.0206 0.0302 0.0366
Toxoplasma gondii target of rapamycin (TOR), putative 0.007 0.0089 0.2144
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0002 0.0002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0021 0.0013 0.0012
Schistosoma mansoni ferritin 0.0014 0.0002 0.0007
Echinococcus granulosus thioredoxin glutathione reductase 0.0034 0.0034 0.0039
Echinococcus multilocularis cpg binding protein 0.0144 0.0205 0.0248
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0048 0.0056 0.1912
Onchocerca volvulus 0.0206 0.0302 0.1097
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0078 0.0101 0.0118
Schistosoma mansoni nuclear hormone receptor 0.0013 0 0.0001
Brugia malayi jmjC domain containing protein 0.003 0.0027 0.0027
Schistosoma mansoni sodium/chloride dependent transporter 0.0246 0.0364 0.1321
Trypanosoma brucei C-8 sterol isomerase, putative 0.6425 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0164 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Brugia malayi Isocitrate dehydrogenase 0.0021 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0021 0.0012 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0206 0.0302 0.1097
Schistosoma mansoni opsin-like receptor 0.0206 0.0302 0.1097
Trypanosoma brucei trypanothione reductase 0.0034 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Schistosoma mansoni lamin 0.0067 0.0085 0.0309
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0291 0.0434 0.1575
Toxoplasma gondii isocitrate dehydrogenase 0.0021 0.0013 0.0128
Mycobacterium leprae Probable lipase LipE 0.0194 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.0283 0.0283
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0023 0.0084
Onchocerca volvulus 0.0169 0.0243 0.0882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0066 0.0984
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0003 0.001
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0021 0.0012 0.0014
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0013 0.0001 0.0001
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0031 0.0029 0.0028
Brugia malayi ORL1-like opioid receptor 0.0206 0.0302 0.0302
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0032 0.0031 0.0036
Schistosoma mansoni hypothetical protein 0.0164 0.0236 0.0857
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Entamoeba histolytica hypothetical protein 0.0047 0.0053 0.4141
Echinococcus multilocularis dnaJ subfamily B 0.0964 0.1484 0.1802
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0169 0.0243 0.6225
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0169 0.0243 0.0243
Loa Loa (eye worm) neuropeptide F receptor 0.0206 0.0302 0.0302
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0087 0.0116 0.06
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0067 0.0084 0.1246
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0 0.0001
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0021 0.0012 0.0012
Brugia malayi Serotonin receptor 0.5367 0.8351 0.8351
Schistosoma mansoni voltage-gated potassium channel 0.0084 0.0112 0.0405
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0188 0.0684
Echinococcus granulosus dro:myosuppressin receptor 0.0206 0.0302 0.0353
Mycobacterium tuberculosis Conserved protein 0.0194 0.0283 0.1473
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0194 0.0283 0.1027
Loa Loa (eye worm) TYRA-2 protein 0.0206 0.0302 0.0302
Brugia malayi Smad1 0.0014 0.0002 0.0002
Echinococcus granulosus serotonin receptor 0.0206 0.0302 0.0353
Loa Loa (eye worm) hypothetical protein 0.0326 0.0489 0.0488
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.3284 0.5101 0.5101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0023 0.0023
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0033 0.1102
Loa Loa (eye worm) raf kinase 0.0044 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0901 0.1386 0.1386
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0206 0.0302 0.0302
Brugia malayi MH2 domain containing protein 0.0014 0.0002 0.0002
Schistosoma mansoni DNA polymerase eta 0.0013 0.0001 0.0003
Schistosoma mansoni ferritin 0.0014 0.0002 0.0007
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0021 0.0012 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0094 0.0126 0.188
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0012 0.0172
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.0016 0.0005 0.0337
Echinococcus multilocularis survival motor neuron protein 1 0.0183 0.0266 0.0322
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0206 0.0302 0.1097
Plasmodium vivax amine transporter, putative 0.0169 0.0243 0.8576
Loa Loa (eye worm) hypothetical protein 0.0355 0.0533 0.0533
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0075 0.0096 0.0095
Brugia malayi RNA binding protein 0.0134 0.0188 0.0188
Echinococcus granulosus sodium:glucose cotransporter 2 0.0024 0.0018 0.002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0012 0.0015
Loa Loa (eye worm) MH1 domain-containing protein 0.0014 0.0002 0.0002
Brugia malayi Inositol-1 0.0038 0.0039 0.0039
Echinococcus multilocularis GA binding protein alpha chain 0.0046 0.0052 0.0062
Echinococcus multilocularis glutamate receptor 2 0.0019 0.001 0.0011
Toxoplasma gondii isocitrate dehydrogenase 0.0021 0.0013 0.0128
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.001
Mycobacterium tuberculosis Conserved protein 0.0194 0.0283 0.1473
Schistosoma mansoni hypothetical protein 0.0164 0.0236 0.0857
Brugia malayi hypothetical protein 0.0206 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0008
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0012 0.0012
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0169 0.0243 0.0882
Trichomonas vaginalis helicase, putative 0.0031 0.0028 0.0409
Echinococcus multilocularis fmrfamide receptor 0.0206 0.0302 0.0366
Brugia malayi putative neuropeptide receptor 0.0206 0.0302 0.0302
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0169 0.0243 0.0295
Brugia malayi hypothetical protein 0.0206 0.0302 0.0302
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0029 0.0025 0.0092
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0206 0.0302 0.0366
Trypanosoma cruzi ISWI complex protein 0.0014 0.0002 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0262 0.3914
Brugia malayi Thioredoxin reductase 0.0034 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0206 0.0302 0.0302
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0023 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0118 0.0165 0.246
Echinococcus multilocularis GPCR, family 2 0.0164 0.0236 0.0286
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0001 0.0008
Echinococcus granulosus jumonji domain containing protein 0.0026 0.002 0.0023
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0206 0.0302 0.0353
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0071 0.0257
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0094 0.0126 1
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0188 0.0684
Loa Loa (eye worm) hypothetical protein 0.0067 0.0085 0.0085
Mycobacterium ulcerans beta-lactamase 0.0194 0.0283 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0019 0.001 0.0011

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 2.61 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 3.12 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 4 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 6.88 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 44 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 46 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 97 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 13.87 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 4 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 44 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 46 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 97 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.03 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.93736 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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