Detailed information for compound 63435

Basic information

Technical information
  • TDR Targets ID: 63435
  • Name: 2-(tert-butylamino)-1-(7-ethyl-1-benzofuran-2 -yl)ethanol
  • MW: 261.359 | Formula: C16H23NO2
  • H donors: 2 H acceptors: 1 LogP: 2.86 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cccc2c1oc(c2)C(CNC(C)(C)C)O
  • InChi: 1S/C16H23NO2/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4/h6-9,13,17-18H,5,10H2,1-4H3
  • InChiKey: SSEBTPPFLLCUMN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(tert-butylamino)-1-(7-ethylbenzofuran-2-yl)ethanol
  • 2-(tert-butylamino)-1-(7-ethyl-2-benzofuranyl)ethanol
  • bufuralol
  • 64100-62-5
  • 57704-15-1
  • 64100-61-4
  • 2-Benzofuranmethanol, alpha-(((1,1-dimethylethyl)amino)methyl)-7-ethyl-, (+)-
  • Ro-34787
  • (S)-Bufuralol
  • 2-Benzofuranmethanol, alpha-(((1,1-dimethylethyl)amino)methyl)-7-ethyl-, (-)-
  • C13769
  • NCGC00165965-01
  • (RS)-alpha-(tert-Butylamino)methyl)-7-ethyl-12-benzofuranmethanol
  • 1-(7-Ethylbenzofuran-2-yl)-2-tert-butylamino-1-hydroxyethane
  • Bufuralol [BAN:INN]
  • Bufuralolum [INN-Latin]
  • EINECS 259-112-5
  • Ro 3-4787
  • alpha-((tert-Butylamino)methyl)-7-ethyl-2-benzofuranmethanol
  • (R)-Bufuralol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0374 0.2725
Schistosoma mansoni tar DNA-binding protein 0.0097 0.0507 0.0502
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0046 0.0182 0.0177
Entamoeba histolytica acyl-coA synthetase, putative 0.0062 0.0284 0.5426
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0236 0.0231
Schistosoma mansoni tar DNA-binding protein 0.0097 0.0507 0.0502
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0063 0.0288 0.0283
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0153 0.057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0194 0.1417
Entamoeba histolytica hypothetical protein 0.0036 0.012 0.224
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0046 0.0182 0.0621
Trypanosoma brucei glucosidase, putative 0.0055 0.024 0.1747
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0376 0.0371
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.002 0.0057
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0374 0.1421
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0136 0.0988
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0224 0.0966
Schistosoma mansoni hypothetical protein 0.0355 0.2149 0.2145
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0031 0.0086 0.0593
Brugia malayi Glycosyl hydrolases family 31 protein 0.0248 0.1468 0.6455
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.002 0.0057
Trichomonas vaginalis alpha-glucosidase, putative 0.0055 0.024 0.0904
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0118 0.0499
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0062 0.0284 0.4189
Brugia malayi photoreceptor-specific nuclear receptor 0.0046 0.0182 0.078
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0031 0.009 0.0285
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0061
Schistosoma mansoni protein phosphatase 2C 0.0038 0.013 0.0125
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0095 0.0492 0.0487
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0027 0.0094
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0022 0.0028 0.0204
Brugia malayi jmjC domain containing protein 0.0038 0.013 0.0549
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.024 0.1747
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0052 0.0218 0.0213
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0031 0.0086 0.122
Trichomonas vaginalis esterase, putative 0.0076 0.0374 0.1421
Loa Loa (eye worm) hypothetical protein 0.0038 0.013 0.0443
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0486 0.2984 1
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.002 0.0057
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0031 0.0086 0.122
Brugia malayi Importin beta-1 subunit 0.0045 0.0174 0.0745
Schistosoma mansoni polycystin 1-related 0.002 0.0018 0.0013
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0023 0.0038 0.0153
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0031 0.0086 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0046 0.0182 0.078
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0194 0.1417
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0079 0.0074
Mycobacterium leprae Probable lipase LipE 0.0076 0.0374 0.725
Entamoeba histolytica acyl-CoA synthetase, putative 0.0062 0.0284 0.5426
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0182 0.0177
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0029 0.0076 0.055
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0046 0.0182 0.078
Mycobacterium ulcerans hypothetical protein 0.0076 0.0374 0.5542
Brugia malayi Ets-domain containing protein 0.0076 0.0376 0.1635
Brugia malayi beta-lactamase 0.0076 0.0374 0.1626
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0062 0.0284 0.548
Brugia malayi nuclear receptor NHR-67 0.0022 0.0027 0.0098
Brugia malayi MH2 domain containing protein 0.0092 0.0475 0.2075
Leishmania major cathepsin L-like protease 0.0048 0.0194 0.1384
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0038 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0046 0.0182 0.078
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0079 0.0074
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0023 0.0038 0.011
Loa Loa (eye worm) hypothetical protein 0.0079 0.0394 0.1345
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0161 0.0916 0.4021
Schistosoma mansoni steroid hormone receptor ad4bp 0.0046 0.0182 0.0177
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0018 0.0005 0.0038
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0091 0.0468 0.6955
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0062 0.0284 0.0935
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0608 0.3766 0.3762
Schistosoma mansoni rab6-interacting 0.002 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.0045 0.0174 0.0594
Brugia malayi Cytochrome P450 family protein 0.0031 0.0086 0.0358
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.015
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0374 0.1421
Wolbachia endosymbiont of Brugia malayi (3R)-hydroxymyristoyl-ACP dehydratase 0.0249 0.1477 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0031 0.0086 0.122
Schistosoma mansoni coup transcription factor 0.0046 0.0182 0.0177
Brugia malayi Cytochrome P450 family protein 0.0041 0.0148 0.063
Brugia malayi hypothetical protein 0.0024 0.0044 0.0171
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0079 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.011 0.0591 0.4308
Loa Loa (eye worm) steroid hormone receptor 0.0046 0.0182 0.0621
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0023 0.0038 0.0494
Brugia malayi Steroid receptor seven-up type 2 0.0046 0.0182 0.078
Plasmodium vivax hypothetical protein, conserved 0.003 0.0079 0.0502
Schistosoma mansoni hypothetical protein 0.0622 0.3852 0.3849
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0182 0.078
Leishmania major cathepsin L-like protease 0.0048 0.0194 0.1384
Brugia malayi jmjC domain containing protein 0.0144 0.0806 0.3535
Entamoeba histolytica acyl-CoA synthetase, putative 0.0062 0.0284 0.5426
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0055 0.024 0.4567
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0046 0.0182 0.0177
Plasmodium vivax JmjC domain containing protein 0.0038 0.013 0.0846
Echinococcus multilocularis peregrin 0.003 0.0079 0.0074
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0018 0.0005 0.0038
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0027 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.0062 0.0284 0.4189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0046 0.0182 0.0621
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0153 0.0148
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0182 0.0177
Brugia malayi nuclear receptor RXR 0.0022 0.0027 0.0098
Schistosoma mansoni alpha-glucosidase 0.0213 0.1248 0.1244
Brugia malayi tailless protein 0.0022 0.0027 0.0098
Loa Loa (eye worm) RNA binding protein 0.0097 0.0507 0.173
Loa Loa (eye worm) jmjC domain-containing protein 0.0144 0.0806 0.2754
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0027 0.0022
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.1315 0.4492
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0514 0.1707
Mycobacterium ulcerans hypothetical protein 0.0123 0.067 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0027 0.0022
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0233 0.1372 1
Brugia malayi beta-lactamase family protein 0.0076 0.0374 0.1626
Trichomonas vaginalis sucrase-isomaltase, putative 0.0055 0.024 0.0904
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0094
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0018 0.0005 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0236 0.0231
Loa Loa (eye worm) doublecortin family protein 0.002 0.0018 0.0061
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0031 0.0086 0.122
Trichomonas vaginalis maltase-glucoamylase, putative 0.0055 0.024 0.0904
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0063 0.0288 0.2068
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0629
Echinococcus multilocularis 0.0031 0.0086 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0194 0.1417
Onchocerca volvulus 0.0037 0.0126 0.0465
Echinococcus granulosus lysine specific demethylase 5A 0.0144 0.0806 0.0802
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0046 0.018 0.0586
Leishmania major trypanothione reductase 0.0039 0.0136 0.0954
Onchocerca volvulus 0.0031 0.0088 0.032
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0091 0.0468 0.0463
Echinococcus multilocularis ecdysone induced protein 78C 0.0046 0.0182 0.0177
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0018
Onchocerca volvulus 0.0425 0.26 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0248 0.1468 0.1464
Loa Loa (eye worm) hypothetical protein 0.0038 0.013 0.0443
Schistosoma mansoni hypothetical protein 0.003 0.0079 0.0074
Loa Loa (eye worm) TAR-binding protein 0.0097 0.0507 0.173
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0153 0.0148
Echinococcus multilocularis protein dispatched 1 0.0036 0.012 0.0115
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0046 0.018 0.0175
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0022 0.0028 0.0033
Trichomonas vaginalis alpha-glucosidase, putative 0.0055 0.024 0.0904
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0091 0.0468 0.341
Schistosoma mansoni zinc finger protein 0.0022 0.0027 0.0022
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0091 0.0468 0.0463
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0168 0.0547
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0288 0.0283
Onchocerca volvulus 0.0022 0.0027 0.0086
Loa Loa (eye worm) hypothetical protein 0.0062 0.0284 0.0969
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0022 0.0028 0.0342
Brugia malayi AMP-binding enzyme family protein 0.0062 0.0284 0.1229
Brugia malayi Glycosyl hydrolases family 31 protein 0.0055 0.024 0.1035
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0031 0.0086 0.0272
Loa Loa (eye worm) hypothetical protein 0.0076 0.0374 0.1277
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0099 0.0519 0.0514
Plasmodium falciparum acyl-CoA synthetase 0.0046 0.0184 0.1215
Echinococcus multilocularis neutral alpha glucosidase AB 0.0055 0.024 0.0235
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0027 0.0098
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0451 0.1496
Toxoplasma gondii aldehyde dehydrogenase 0.0046 0.018 0.0251
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.013 0.0443
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.0038 0.0494
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0376 0.1283
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0281 0.096
Mycobacterium ulcerans hypothetical protein 0.0062 0.0284 0.4189
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0023 0.0038 0.0277
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0031 0.0086 0.122
Brugia malayi hypothetical protein 0.0022 0.0027 0.0098
Onchocerca volvulus 0.0076 0.0374 0.1421
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0153 0.0148
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0027 0.0022
Schistosoma mansoni microtubule-associated protein tau 0.1587 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0062 0.0284 0.2038
Echinococcus granulosus peregrin 0.003 0.0079 0.0074
Echinococcus multilocularis microtubule associated protein 2 0.1587 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0046 0.0182 0.078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0194 0.1417
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0031 0.0086 0.0272
Schistosoma mansoni cellular tumor antigen P53 0.0037 0.0126 0.0121
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0018 0.0005 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0062 0.0284 0.2038
Plasmodium falciparum beta-hydroxyacyl-ACP dehydratase 0.0249 0.1477 1
Brugia malayi nuclear hormone receptor 0.0046 0.0182 0.078
Echinococcus multilocularis lysine specific demethylase 6a 0.0038 0.013 0.0125
Brugia malayi hypothetical protein 0.0022 0.0027 0.0098
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0079 0.027
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0091 0.0468 1
Schistosoma mansoni phd/f-box containing protein 0.0038 0.013 0.0125
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.0038 0.0494
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0031 0.0086 0.0272
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0374 0.1277
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0023 0.0038 0.024
Mycobacterium tuberculosis Probable oxidoreductase 0.0022 0.0028 0.0076
Brugia malayi hypothetical protein 0.036 0.2181 0.9599
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.004 0.0146 0.014
Brugia malayi nuclear receptor NHR-88 0.0022 0.0027 0.0098
Trypanosoma brucei trypanothione reductase 0.0039 0.0136 0.0988
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0182 0.0177
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0016 0.0041
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0094
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0451 0.8767
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0091 0.0468 0.3385
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0062 0.0284 0.548
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0139 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0182 0.078
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0376 0.0371
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0374 0.1626
Mycobacterium leprae putative cytochrome p450 0.0031 0.0086 0.1596
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0374 0.0369
Echinococcus multilocularis sterol regulatory element binding protein 0.0032 0.0091 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0374 0.2725
Echinococcus granulosus RUN 0.002 0.0018 0.0013
Leishmania major hypothetical protein, conserved 0.0038 0.013 0.0911
Echinococcus multilocularis importin subunit beta 1 0.0045 0.0174 0.0169
Schistosoma mansoni RAR-like nuclear receptor 0.0046 0.0182 0.0177
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0374 0.1237
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.024 0.1747
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0148 0.0506
Echinococcus multilocularis FTZ F1 alpha 0.0046 0.0182 0.0177
Loa Loa (eye worm) DR-78 0.0022 0.0027 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0091 0.0332
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0182 0.0177
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0451 0.1496
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.018 0.0175
Onchocerca volvulus Protein ultraspiracle homolog 0.0046 0.0182 0.0681
Plasmodium vivax importin-beta 2, putative 0.0045 0.0174 0.1147
Onchocerca volvulus 0.0046 0.0182 0.0681
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0031 0.0086 0.122
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0031 0.0086 0.0272
Schistosoma mansoni jumonji/arid domain-containing protein 0.0144 0.0806 0.0802
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0027 0.0022
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0031 0.0086 0.0629
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0059 0.0267 0.0376
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0091 0.0468 0.2986
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0055 0.024 0.0904
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0153 0.0148
Schistosoma mansoni transcription factor LCR-F1 0.0099 0.0519 0.0514
Echinococcus multilocularis snurportin 1 0.0477 0.2928 0.2924
Schistosoma mansoni tar DNA-binding protein 0.0097 0.0507 0.0502
Brugia malayi nuclear hormone receptor 0.0022 0.0027 0.0098
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0031 0.0086 0.0272
Schistosoma mansoni ets-related 0.0232 0.1366 0.1361
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0044 0.0171
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0182 0.078
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0016 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0046 0.0182 0.078
Echinococcus multilocularis geminin 0.0355 0.2149 0.2145
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0063 0.0288 0.0949
Echinococcus granulosus sterol regulatory element binding protein 0.0032 0.0091 0.0086
Plasmodium falciparum phd finger protein, putative 0.003 0.0079 0.0502
Onchocerca volvulus 0.0044 0.0168 0.0626
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0046 0.0182 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0046 0.0182 0.0621
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0153 0.2726
Toxoplasma gondii ABC1 family protein 0.0076 0.0374 0.0529
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0018 0.0005 0.0018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.015
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0079
Onchocerca volvulus Bile acid receptor homolog 0.0046 0.0182 0.0681
Echinococcus granulosus jumonji domain containing 1A 0.0038 0.013 0.0125
Trichomonas vaginalis importin beta-1, putative 0.0036 0.012 0.0443
Loa Loa (eye worm) cytochrome P450 0.0031 0.0086 0.0295
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0153 0.0148
Echinococcus multilocularis lysosomal alpha glucosidase 0.0248 0.1468 0.1464
Trypanosoma brucei glycosyl hydrolase-like protein 0.002 0.002 0.0145
Onchocerca volvulus 0.0026 0.0055 0.0194
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0094
Echinococcus granulosus neutral alpha glucosidase AB 0.0055 0.024 0.0235
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0016 0.0011
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.0046 0.0182 0.0621
Schistosoma mansoni alpha glucosidase 0.0055 0.024 0.0235
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0074 0.036 0.6911
Echinococcus multilocularis RUN 0.002 0.0018 0.0013
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0027 0.0022
Onchocerca volvulus 0.0022 0.0027 0.0086
Plasmodium falciparum importin beta, putative 0.0045 0.0174 0.1147
Schistosoma mansoni lipoxygenase 0.0056 0.0249 0.0244
Leishmania major cytochrome p450-like protein 0.0041 0.0148 0.1045
Echinococcus multilocularis cpg binding protein 0.0046 0.0184 0.0178
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0023 0.0038 0.0277
Schistosoma mansoni nuclear receptor 0.0022 0.0027 0.0022
Brugia malayi RNA recognition motif domain containing protein 0.0097 0.0507 0.2212
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0018 0.0005 0.0018
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.002 0.002 0.0145
Leishmania major cytochrome p450-like protein 0.0031 0.0086 0.0593
Brugia malayi conserved hypotetical protein 0.0022 0.0027 0.0098
Echinococcus granulosus X box binding protein 1 0.0222 0.1304 0.1299
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0016 0.0115
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0054 0.0236 0.0231
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0023 0.0038 0.0033
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0046 0.0184 0.1015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0194 0.1417
Trichomonas vaginalis alpha-glucosidase, putative 0.0055 0.024 0.0904
Plasmodium falciparum thioredoxin reductase 0.0039 0.0136 0.0885
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.004 0.0146 0.014
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0023 0.0038 0.0494
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.002 0.0057
Plasmodium vivax acyl-CoA synthetase, putative 0.0046 0.0184 0.1215
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.0514 0.1707
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0031 0.0086 0.122
Trypanosoma brucei cytochrome P450, putative 0.0041 0.0148 0.1079
Trypanosoma cruzi cruzipain precursor, putative 0.0048 0.0194 0.1417
Echinococcus multilocularis jumonji domain containing 1A 0.0038 0.013 0.0125
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0068
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0038 0.013 0.0179
Loa Loa (eye worm) hypothetical protein 0.0041 0.0153 0.0523
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0046 0.0182 0.0177
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0031 0.0086 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0046 0.0182 0.0621
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0182 0.078
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0031 0.0086 0.0272
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0027 0.0094
Trypanosoma cruzi major cysteine proteinase, putative 0.0038 0.0129 0.0941
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.013 0.0945
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0062 0.0284 0.0935
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0046 0.0182 0.0177
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0016 0.0054
Echinococcus granulosus cytochrome P450 2K1 0.0031 0.0086 0.0081
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0079
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.018 0.2623
Loa Loa (eye worm) hypothetical protein 0.0046 0.0182 0.0621
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0031 0.0086 0.0272
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0224 0.0966
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0031 0.0086 0.0272
Leishmania major alpha glucosidase II subunit, putative 0.0055 0.024 0.1716
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0018 0.0013
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.018 0.2623
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0136 0.0463
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0031 0.0086 0.122
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0016 0.0035
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0094
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0374 0.2725
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0094
Loa Loa (eye worm) hypothetical protein 0.0062 0.0284 0.0969
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0182 0.078
Leishmania major oxidoreductase-like protein 0.0022 0.0028 0.0167
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0027 0.0022
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0031 0.0086 0.122
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.0038 0.0494
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.003 0.0081 0.0591
Echinococcus granulosus survival motor neuron protein 1 0.036 0.2181 0.2176
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0031 0.0086 0.122
Brugia malayi steroid hormone receptor 0.0046 0.0182 0.078
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0031 0.0086 0.0272
Loa Loa (eye worm) hypothetical protein 0.0076 0.0374 0.1277
Brugia malayi cytochrome P450 0.0031 0.0086 0.0358
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0374 0.1237
Leishmania major cytochrome p450-like protein 0.0031 0.0086 0.0593
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0023 0.0038 0.0223
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0018 0.0005 0.0038
Mycobacterium tuberculosis Conserved protein 0.0076 0.0374 0.1237
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.1111 0.6967 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0153 0.0148
Brugia malayi hypothetical protein 0.002 0.0018 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0094
Schistosoma mansoni cpg binding protein 0.0044 0.0168 0.0163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0194 0.1417
Schistosoma mansoni cytochrome P450 0.0031 0.0086 0.0081
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0099 0.0519 0.1981
Brugia malayi follicle stimulating hormone receptor 0.0224 0.1315 0.5781
Echinococcus multilocularis tumor protein p63 0.0253 0.1505 0.15
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0023 0.0038 0.0277
Echinococcus granulosus tar DNA binding protein 0.0097 0.0507 0.0502
Schistosoma mansoni cpg binding protein 0.0046 0.0184 0.0178
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0033 0.0028
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0044 0.015
Echinococcus granulosus ecdysone induced protein 78C 0.0046 0.0182 0.0177
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0148 0.1079
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0061
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0374 0.1421
Mycobacterium tuberculosis Conserved protein 0.0076 0.0374 0.1237
Loa Loa (eye worm) hypothetical protein 0.0054 0.0236 0.0807
Leishmania major 4-coumarate:coa ligase-like protein 0.0062 0.0284 0.2038
Brugia malayi F/Y-rich N-terminus family protein 0.0025 0.0049 0.0193
Brugia malayi hypothetical protein 0.0024 0.0044 0.0171
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0031 0.0086 0.122
Schistosoma mansoni tar DNA-binding protein 0.0097 0.0507 0.0502
Trypanosoma brucei oxidoreductase-like protein 0.0022 0.0028 0.0204
Echinococcus multilocularis phd:f box containing protein 0.0038 0.013 0.0125
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0094
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.013 0.0945
Brugia malayi Cytochrome P450 family protein 0.0041 0.0148 0.063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0194 0.1417
Schistosoma mansoni hypothetical protein 0.0031 0.0086 0.0081
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0079
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0022 0.0028 0.0342
Loa Loa (eye worm) hypothetical protein 0.0076 0.0374 0.1277
Schistosoma mansoni hypothetical protein 0.002 0.0018 0.0013
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0184 0.269
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0031 0.0086 0.122
Schistosoma mansoni phosphatidylserine receptor 0.0038 0.013 0.0125
Toxoplasma gondii hypothetical protein 0.0038 0.0129 0.0177
Echinococcus multilocularis X box binding protein 1 0.0222 0.1304 0.1299
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0099 0.0519 0.0738
Onchocerca volvulus 0.0054 0.0236 0.0891
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0046 0.0182 0.0177
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.013 0.0443
Brugia malayi Glycosyl hydrolases family 31 protein 0.002 0.002 0.0065
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0374 0.1237
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0018 0.0013
Brugia malayi Ets-domain containing protein 0.0076 0.0376 0.1635
Loa Loa (eye worm) oxidoreductase 0.0023 0.0038 0.013
Brugia malayi hypothetical protein 0.0092 0.0475 0.2073
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0046 0.0182 0.0177
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0023 0.0038 0.0639
Onchocerca volvulus 0.0143 0.0802 0.3073
Loa Loa (eye worm) hypothetical protein 0.0062 0.0284 0.0969
Brugia malayi AMP-binding enzyme family protein 0.0062 0.0284 0.1229
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0027 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0194 0.1417
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0016 0.0046
Mycobacterium tuberculosis Probable reductase 0.0088 0.0451 0.1496
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0094
Loa Loa (eye worm) hypothetical protein 0.0037 0.0126 0.043
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0027 0.0022
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0153 0.1081
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0094
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0046 0.0182 0.0177
Loa Loa (eye worm) cytochrome P450 family protein 0.0115 0.0624 0.2131
Giardia lamblia PHD finger protein 15 0.003 0.0079 0.1259
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0016 0.0205
Onchocerca volvulus 0.002 0.0018 0.0048
Schistosoma mansoni alpha-glucosidase 0.0213 0.1248 0.1244
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0033 0.0098 0.0713
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0018
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.0038 0.0494
Brugia malayi hypothetical protein 0.0099 0.0519 0.2266
Schistosoma mansoni hypothetical protein 0.0477 0.2928 0.2924
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0288 0.425
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0099 0.0519 0.1981
Loa Loa (eye worm) hypothetical protein 0.0053 0.0224 0.0766
Echinococcus multilocularis lysosomal alpha glucosidase 0.0248 0.1468 0.1464
Trypanosoma brucei importin beta-1 subunit, putative 0.0045 0.0174 0.1269
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0477 0.2928 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0153 0.2878
Leishmania major importin beta-1 subunit, putative 0.0036 0.012 0.0841
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0161 0.0916 0.0912
Loa Loa (eye worm) beta-lactamase 0.0076 0.0374 0.1277
Schistosoma mansoni hypothetical protein 0.0099 0.0519 0.0514
Trichomonas vaginalis alpha-glucosidase, putative 0.0055 0.024 0.0904
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0153 0.057
Schistosoma mansoni hypothetical protein 0.0222 0.1304 0.1299
Entamoeba histolytica hypothetical protein 0.0099 0.0519 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0097 0.0507 0.173
Plasmodium falciparum JmjC domain-containing protein, putative 0.0038 0.013 0.0846
Echinococcus granulosus expressed conserved protein 0.0069 0.0332 0.0326
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0374 0.1421
Schistosoma mansoni lipoxygenase 0.002 0.0018 0.0013
Trypanosoma cruzi importin beta-1 subunit, putative 0.0036 0.012 0.0876
Loa Loa (eye worm) hypothetical protein 0.0046 0.0182 0.0621
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0161 0.0916 0.0912
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0091 0.0468 0.1598
Onchocerca volvulus 0.002 0.0018 0.0048
Schistosoma mansoni hypothetical protein 0.0036 0.0118 0.0113
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0374 0.2271 0.7757
Loa Loa (eye worm) hypothetical protein 0.0065 0.0305 0.1042
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0451 0.1496
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.0514 0.1707
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0046 0.0182 0.0177
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0236 0.0231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0161 0.0916 0.0912
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0031 0.0086 0.122
Loa Loa (eye worm) hypothetical protein 0.0032 0.0091 0.0312
Loa Loa (eye worm) hypothetical protein 0.0046 0.0182 0.0621
Mycobacterium ulcerans acyl-CoA synthetase 0.0062 0.0284 0.4189
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0031 0.0086 0.122
Echinococcus granulosus snurportin 1 0.0477 0.2928 0.2924
Brugia malayi jmjC domain containing protein 0.0038 0.013 0.0549
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0018 0.0085
Onchocerca volvulus 0.0062 0.0284 0.1074
Schistosoma mansoni hypothetical protein 0.0355 0.2149 0.2145
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0036 0.012 0.0443
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0059 0.0267 0.3938
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.027
Schistosoma mansoni gabp alpha 0.0076 0.0376 0.0371
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0161 0.0916 0.0912
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.002 0.002 0.0145
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0079 0.0074
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.002 0.002 0.0057
Schistosoma mansoni patched 1 0.0032 0.0091 0.0086
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0036 0.012 0.0443
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0044 0.0039
Mycobacterium ulcerans beta-lactamase 0.0076 0.0374 0.5542
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.0038 0.0494
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0099 0.0519 0.3492
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0046 0.018 0.0175
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0031 0.0086 0.0272
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0031 0.0086 0.122
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0063 0.0288 0.1247
Schistosoma mansoni thyroid hormone receptor 0.0046 0.0182 0.0177
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0031 0.0086 0.0272
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0161 0.0916 0.0912
Brugia malayi RNA binding protein 0.0097 0.0507 0.2212
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0153 0.0148
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0153 0.0652
Brugia malayi Thioredoxin reductase 0.0039 0.0136 0.0575
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0194 0.1417
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0023 0.0038 0.0033
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0027 0.0094
Toxoplasma gondii histone lysine methyltransferase SET1 0.0085 0.0429 0.0609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0062 0.0284 0.4189
Brugia malayi hypothetical protein 0.002 0.0018 0.0055
Onchocerca volvulus 0.0076 0.0374 0.1421
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0168 0.0547
Loa Loa (eye worm) hypothetical protein 0.036 0.2181 0.7447
Echinococcus multilocularis expressed conserved protein 0.0069 0.0332 0.0326
Mycobacterium tuberculosis Conserved hypothetical protein 0.0123 0.067 0.2233
Toxoplasma gondii exonuclease III APE 0.002 0.0016 0.0015
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.0562 0.0557
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0374 0.2503
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.0086 0.0629
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0031 0.0086 0.122
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0023 0.0038 0.0646
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0027 0.0098
Brugia malayi Cytochrome P450 family protein 0.0115 0.0624 0.2731
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0094
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0068 0.0326 0.1113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0236 0.0231
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0027 0.0098
Schistosoma mansoni nuclear receptor 0.0022 0.0027 0.0022
Brugia malayi Bromodomain containing protein 0.003 0.0079 0.0326
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0203 0.1182 0.1178
Mycobacterium leprae Conserved hypothetical protein 0.0031 0.0086 0.1596
Leishmania major mitochondrial DNA polymerase beta 0.0233 0.1372 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0074 0.036 0.1566
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0099 0.0519 0.1981
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.002 0.002 0.0057
Toxoplasma gondii beta-hydroxyacyl-acyl carrier protein dehydratase (FABZ) 0.0249 0.1477 0.2115
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0374 0.1237
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0194 0.1417
Toxoplasma gondii thioredoxin reductase 0.0039 0.0136 0.0187
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0249 0.0244
Echinococcus granulosus Protein patched homolog 1 0.0032 0.0091 0.0086
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.0038 0.0494
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0062 0.0284 0.4189
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.011 0.0591 0.4308
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0062 0.0284 0.4189
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.0514 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0182 0.0621
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0046 0.0182 0.0177
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0016 0.0077
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0063 0.0288 0.0283
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0168 0.0547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0194 0.1417
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0031 0.0086 0.0272
Loa Loa (eye worm) hypothetical protein 0.0092 0.0475 0.1622
Echinococcus granulosus phd:f box containing protein 0.0038 0.013 0.0125
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0031 0.0086 0.0272
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0022 0.0028 0.0342
Schistosoma mansoni jumonji domain containing protein 0.0183 0.1054 0.105
Schistosoma mansoni jumonji/arid domain-containing protein 0.0144 0.0806 0.0802
Loa Loa (eye worm) glutathione reductase 0.0039 0.0136 0.0463
Loa Loa (eye worm) fli-1 protein 0.0232 0.1366 0.4665
Schistosoma mansoni tar DNA-binding protein 0.0097 0.0507 0.0502
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0094
Echinococcus granulosus Niemann Pick C1 protein 0.0074 0.036 0.0355
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0629
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0033 0.0098 0.0713
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0224 0.0766
Brugia malayi jmjC domain containing protein 0.0038 0.013 0.0549
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0374 0.5542
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0031 0.0086 0.0272
Plasmodium falciparum glutathione reductase 0.0039 0.0136 0.0885
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0182 0.078
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0374 0.725
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0027 0.0022
Brugia malayi nuclear receptor NHR-88 0.0046 0.0182 0.078
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0038 0.013 0.0945
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0018 0.0005 0.0038
Echinococcus multilocularis JmjC domain containing protein 4 0.0038 0.013 0.0125
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0153 0.1115
Brugia malayi Pre-SET motif family protein 0.0054 0.0236 0.102
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0031 0.0086 0.0272
Brugia malayi CXXC zinc finger family protein 0.0044 0.0168 0.0717
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0016 0.0071
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0091 0.0468 0.341
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0374 0.0369
Brugia malayi jmjC domain containing protein 0.0038 0.013 0.0549
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0046 0.0182 0.0621
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0016 0.0158
Loa Loa (eye worm) hypothetical protein 0.0076 0.0374 0.1277
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0054 0.0236 0.0332
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0027 0.0022
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0374 0.1237
Brugia malayi glutathione reductase 0.0039 0.0136 0.0575
Entamoeba histolytica hypothetical protein 0.0099 0.0519 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0031 0.0086 0.0272
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.011 0.0591 0.4286
Toxoplasma gondii cytochrome p450 superfamily protein 0.0031 0.0086 0.0117
Schistosoma mansoni thyroid hormone receptor 0.0046 0.0182 0.0177
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0079 0.0106
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0044 0.0039
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0153 0.0148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0161 0.0916 0.0912
Brugia malayi CHE-14 protein 0.0032 0.0091 0.038
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0031 0.0086 0.122
Entamoeba histolytica hypothetical protein 0.0099 0.0519 1
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.018 0.0175
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0046 0.0182 0.0177
Onchocerca volvulus 0.0073 0.0357 0.1355
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0044 0.0168 0.1224
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0139 0.0134
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0374 0.1237
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0374 0.0369
Onchocerca volvulus Alhambra homolog 0.003 0.0079 0.0285
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0046 0.018 0.1277
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0031 0.0086 0.122
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0153 0.0148
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.013 0.0443
Loa Loa (eye worm) CYP4Cod1 0.0041 0.0148 0.0506
Mycobacterium ulcerans lipase LipD 0.0076 0.0374 0.5542
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.002 0.002 0.0057
Trichomonas vaginalis set domain proteins, putative 0.0425 0.26 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0182 0.078
Schistosoma mansoni ap endonuclease 0.002 0.0016 0.0011
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.0562 0.0557
Onchocerca volvulus Huntingtin homolog 0.0092 0.0475 0.1811
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0018 0.0013
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.002 0.002 0.0286
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0236 0.0231
Loa Loa (eye worm) transcription factor SMAD2 0.0092 0.0475 0.1624
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0018 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0016 0.0041
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0023 0.0038 0.0047
Onchocerca volvulus 0.0076 0.0374 0.1421
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0038 0.013 0.0179
Schistosoma mansoni ap endonuclease 0.002 0.0016 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0374 0.1421
Loa Loa (eye worm) hypothetical protein 0.0046 0.0182 0.0621
Schistosoma mansoni hypothetical protein 0.0031 0.0084 0.0079
Brugia malayi ecdysone receptor 0.0022 0.0027 0.0098
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0038 0.0145
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0099 0.0519 1
Schistosoma mansoni importin beta-1 0.0045 0.0174 0.0169
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0073 0.0357 0.1551
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0027 0.0022
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0031 0.0086 0.122
Echinococcus granulosus tumor protein p63 0.0253 0.1505 0.15
Mycobacterium ulcerans short chain dehydrogenase 0.0022 0.0028 0.0342
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0046 0.0182 0.0177
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0629
Brugia malayi jmjC domain containing protein 0.0203 0.1182 0.5194
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0031 0.0086 0.0272
Loa Loa (eye worm) hypothetical protein 0.0046 0.0182 0.0621
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0194 0.1417
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0629
Schistosoma mansoni cpg binding protein 0.0046 0.0184 0.0178
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0153 0.1115
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0374 0.5542
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0027 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0055 0.024 0.0904
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0046 0.0182 0.078
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.002 0.0057
Loa Loa (eye worm) hypothetical protein 0.0046 0.0182 0.0621
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0023 0.0038 0.0223
Echinococcus granulosus dnaJ subfamily B 0.0622 0.3852 0.3849
Echinococcus granulosus cpg binding protein 0.0046 0.0184 0.0178
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0044 0.0039
Trichomonas vaginalis maltase-glucoamylase, putative 0.002 0.002 0.0057
Loa Loa (eye worm) hypothetical protein 0.0036 0.0118 0.0404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0046 0.0182 0.0621
Brugia malayi TAR-binding protein 0.0097 0.0507 0.2212
Echinococcus granulosus FTZ F1 alpha 0.0046 0.0182 0.0177
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0033 0.0098 0.0713
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0033 0.0098 0.0713
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0018 0.0013
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0055 0.024 0.0819
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0046 0.0182 0.0177
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0374 0.1237
Echinococcus multilocularis protein patched 0.0032 0.0091 0.0086
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.015
Echinococcus granulosus JmjC domain containing protein 4 0.0038 0.013 0.0125
Leishmania major cathepsin L-like protease 0.0048 0.0194 0.1384
Echinococcus multilocularis thyroid hormone receptor alpha 0.0046 0.0182 0.0177
Echinococcus multilocularis tar DNA binding protein 0.0097 0.0507 0.0502
Leishmania major glycosyl hydrolase-like protein 0.002 0.002 0.0107
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0027 0.0086
Loa Loa (eye worm) CXXC zinc finger family protein 0.0044 0.0168 0.0573
Brugia malayi RNA, U transporter 1 0.0127 0.0699 0.3061
Trypanosoma brucei importin beta-1 subunit, putative 0.0045 0.0174 0.1269
Loa Loa (eye worm) hypothetical protein 0.0074 0.036 0.123
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.0038 0.0494
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0451 0.1496
Brugia malayi Fli-1 protein 0.0232 0.1366 0.6005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.018 0.2623
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0194 0.1417
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.0086 0.0629
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0075 0.0367 0.0362
Plasmodium vivax SET domain protein, putative 0.0054 0.0236 0.1569
Plasmodium vivax glutathione reductase, putative 0.0039 0.0136 0.0885
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0018 0.0085
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0091 0.0468 0.0463
Echinococcus multilocularis Niemann Pick C1 protein 0.0074 0.036 0.0355
Brugia malayi beta-lactamase family protein 0.0076 0.0374 0.1626
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0027 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0046 0.0182 0.0621
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0136 0.0438
Schistosoma mansoni survival motor neuron protein 0.0073 0.0357 0.0352
Chlamydia trachomatis 3-hydroxyacyl-ACP dehydratase 0.0249 0.1477 1
Brugia malayi glucose-6-phosphate dehydrogenase 0.0091 0.0468 0.2041
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0094
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0182 0.0177
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0248 0.1468 0.5014
Mycobacterium ulcerans acyl-CoA synthetase 0.0062 0.0284 0.4189
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0023 0.0038 0.0033
Echinococcus granulosus importin subunit beta 1 0.0045 0.0174 0.0169
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0099 0.0519 0.0514
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0041 0.0148 0.2148
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0027 0.0098
Echinococcus multilocularis lysine specific demethylase 5A 0.0141 0.079 0.0786
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0027 0.0098
Plasmodium vivax beta-hydroxyacyl-ACP dehydratase precursor, putative 0.0249 0.1477 1
Loa Loa (eye worm) oxidoreductase 0.0018 0.0005 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0161 0.0916 0.0912
Schistosoma mansoni rab6-interacting 0.002 0.0018 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0194 0.1417
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0153 0.0148
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.015
Toxoplasma gondii HEAT repeat-containing protein 0.0045 0.0174 0.0243
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0027 0.0022
Brugia malayi PHD-finger family protein 0.003 0.0079 0.0326
Schistosoma mansoni loxhd1 0.002 0.0018 0.0013
Leishmania major hypothetical protein, conserved 0.0076 0.0374 0.2697
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0203 0.1182 0.1178
Loa Loa (eye worm) hypothetical protein 0.0092 0.0475 0.1622
Brugia malayi nuclear receptor RXR 0.0024 0.0044 0.0171
Brugia malayi AMP-binding enzyme family protein 0.0062 0.0284 0.1229
Echinococcus granulosus lysine specific demethylase 6a 0.0038 0.013 0.0125
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0249 0.0244
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0046 0.0182 0.0177
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0046 0.0182 0.0681
Schistosoma mansoni jumonji domain containing protein 0.0038 0.013 0.0125
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0044 0.0039
Loa Loa (eye worm) hypothetical protein 0.0039 0.0137 0.0467
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0629
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0168 0.0547
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0451 0.1496
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0055 0.024 0.0337
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0031 0.0086 0.0629
Echinococcus multilocularis dnaJ subfamily B 0.0622 0.3852 0.3849
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0031 0.0086 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0046 0.0182 0.078
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0094
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0374 0.0369
Onchocerca volvulus Huntingtin homolog 0.0092 0.0475 0.1811
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0023 0.0038 0.0494
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0233 0.1372 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0054 0.0236 0.0231
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.0148 0.1079
Brugia malayi ecdysteroid receptor 0.0046 0.0182 0.078
Echinococcus multilocularis survival motor neuron protein 1 0.036 0.2181 0.2176
Brugia malayi Pre-SET motif family protein 0.0374 0.2271 1
Brugia malayi Doublecortin family protein 0.002 0.0018 0.0055
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0063 0.0288 0.425
Loa Loa (eye worm) MH2 domain-containing protein 0.0092 0.0475 0.1624
Schistosoma mansoni hypothetical protein 0.0073 0.0357 0.0352
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0027 0.0086
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0153 0.1115
Echinococcus granulosus geminin 0.0355 0.2149 0.2145
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0044 0.0171
Entamoeba histolytica hypothetical protein 0.0099 0.0519 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0055 0.024 0.4567
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0018 0.0013
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0016 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0153 0.057
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0032 0.0091 0.0312
Loa Loa (eye worm) hypothetical protein 0.0076 0.0374 0.1277
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.0148 0.0506
Loa Loa (eye worm) hypothetical protein 0.0076 0.0374 0.1277
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0016 0.0115
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0046 0.0184 0.0601
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0136 0.0885
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0016 0.0115
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0055 0.024 0.0904
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0233 0.1372 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0031 0.0086 0.122
Mycobacterium tuberculosis Conserved protein 0.0076 0.0374 0.1237
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.004 0.0143 0.1046
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0161 0.0916 0.313
Leishmania major pteridine reductase 1 0.0022 0.0028 0.0167
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0099 0.0519 0.3492
Schistosoma mansoni retinoic acid receptor RXR 0.0046 0.0182 0.0177
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0038 0.013 0.0125
Mycobacterium ulcerans oxidoreductase 0.0023 0.0038 0.0494
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0182 0.0177

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Clinically relevant substrates of human liver microsomal P450 enzymes, isoform CYP2D6 ChEMBL. No reference
Activity (functional) = 3.74 Beta-blocking activity of the compound was measured by applying the stepwise linear discriminate analysis; Active ChEMBL. No reference
Activity (functional) = 3.74 Beta-blocking activity of the compound was measured by applying the stepwise linear discriminate analysis; Active ChEMBL. No reference
CL (ADMET) = 8.9 ml/min.kg Total body clearance in human ChEMBL. 19445515
CL (ADMET) = 8.9 ml/min.kg Total clearance in human ChEMBL. 20070106
CL (ADMET) = 8.9 ml/min.kg Hepatic clearance in human ChEMBL. 20070106
CL (ADMET) = 51.3 uL/min/10^6cells Intrinsic clearance in cryopreserved human hepatocytes cells assessed per 10'6 cells by LC-MS/MS method ChEMBL. 21998403
CL (ADMET) = 3 uL/min/g Drug metabolism in assessed as human CYP2D6-mediated intrinsic clearance per mg protein ChEMBL. 22942316
CL_renal (ADMET) = 0 ml/min.kg Renal clearance in human ChEMBL. 19445515
CL_renal (ADMET) = 0 ml/min.kg Renal clearance in human ChEMBL. 20070106
delta logD (ADMET) = -0.89 Delta logD (logD6.5 - logD7.4) ChEMBL. 10891117
ED30 (functional) = 53 ug kg-1 Beta-1 adrenergic receptor agonist activity as increased heart rate by 30 beats/min in rats ChEMBL. 2866246
ED30 (functional) > 1000 ug kg-1 Beta-1 adrenergic receptor agonist activity as increased heart rate by 30 beats/min in rats ChEMBL. 2866246
ED50 (functional) = 13 ug kg-1 Antagonistic activity against beta-2 adrenergic receptor as inhibition of vasodepressor response in rats ChEMBL. 2866246
ED50 (functional) = 169 ug kg-1 Antagonistic activity against beta-1 adrenergic receptor to inhibit tachycardia in rats ChEMBL. 2866246
ED50 (functional) > 2000 ug kg-1 Antagonistic activity against beta-1 adrenergic receptor to inhibit tachycardia in rats ChEMBL. 2866246
ED50 (functional) > 2000 ug kg-1 Antagonistic activity against beta-2 adrenergic receptor as inhibition of vasodepressor response in rats ChEMBL. 2866246
F (ADMET) = 79 % Oral bioavailability in human ChEMBL. 10891117
IC50 (ADMET) > 50 uM Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method ChEMBL. 23033255
Inhibition (ADMET) = -13.9 % Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake at 20 uM by scintillation counting ChEMBL. 22541068
Inhibition (ADMET) = -7 % Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake at 20 uM incubated for 5 mins by scintillation counting ChEMBL. 22541068
Inhibition (ADMET) = 23.8 % Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake at 20 uM incubated for 5 mins by scintillation counting ChEMBL. 22541068
ISA (functional) Tested for intrinsic sympathomimetic activity (ISA); Antagonist with partial agonistic properties ChEMBL. 2903243
ISA (functional) 0 Tested for intrinsic sympathomimetic activity (ISA); Antagonist with partial agonistic properties ChEMBL. 2903243
Km (ADMET) = 8.2 uM Drug metabolism in assessed as human CYP2D6-mediated metabolism ChEMBL. 22942316
LD50 (ADMET) = 25.9 mg kg-1 Compound was tested for its toxicity after intravenous administration to mice in experiment 2 ChEMBL. No reference
LD50 (ADMET) = 29.7 mg kg-1 Compound was tested for its toxicity after intravenous administration to mice in experiment 1 ChEMBL. No reference
LD50 (ADMET) = 117 mg kg-1 Compound was tested for its toxicity after oral administration to mice in experiment 1 ChEMBL. No reference
LD50 (ADMET) = 272.9 mg kg-1 Compound was tested for its toxicity after oral administration to mice in experiment 2 ChEMBL. No reference
logD (ADMET) = 1 Partition coefficient (logD6.5) ChEMBL. 10891117
pKa = 9 Ionization constant (pKa) ChEMBL. 10891117
Potency (functional) 100 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Selectivity (binding) Selectivity of the compound towards beta-2 adrenergic receptor; Nonselective towards beta-2 adrenergic receptor ChEMBL. 2903243
Selectivity (binding) Selectivity for beta-1 adrenergic receptor ChEMBL. 2903243
Selectivity (binding) 0 Selectivity for beta-1 adrenergic receptor ChEMBL. 2903243
Selectivity (binding) 0 Selectivity of the compound towards beta-2 adrenergic receptor; Nonselective towards beta-2 adrenergic receptor ChEMBL. 2903243
Vdss (ADMET) = 1.7 L/Kg Volume of distribution at steady state in human ChEMBL. 20070106
Vmax (ADMET) = 70 pmol/min Drug metabolism in assessed as human CYP2D6-mediated maximum rate of reaction per mg protein ChEMBL. 22942316
Vmax (ADMET) = 405 pmol/min Drug metabolism in human liver microsomes assessed as maximum rate of reaction per mg protein by optimal design approach ChEMBL. 22942316

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

6 literature references were collected for this gene.

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