Detailed information for compound 667496

Basic information

Technical information
  • TDR Targets ID: 667496
  • Name: 3-methyl-4-nitro-N-[4-(phenylamino)phenyl]ben zamide
  • MW: 347.367 | Formula: C20H17N3O3
  • H donors: 2 H acceptors: 3 LogP: 4.49 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1)C)[N+](=O)[O-])Nc1ccc(cc1)Nc1ccccc1
  • InChi: 1S/C20H17N3O3/c1-14-13-15(7-12-19(14)23(25)26)20(24)22-18-10-8-17(9-11-18)21-16-5-3-2-4-6-16/h2-13,21H,1H3,(H,22,24)
  • InChiKey: JDVIBASNOTYKSC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • MLS001163286
  • N-(4-anilinophenyl)-3-methyl-4-nitrobenzamide
  • SMR000497182
  • ZINC04758645
  • Oprea1_498345

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Loa Loa (eye worm) glutathione reductase 0.01 0.0912 0.1549
Leishmania major trypanothione reductase 0.01 0.0912 0.851
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.106 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.0571 0.1557
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0144 0.0137
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0179 0.1735 0.2275
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0007 0.0012
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0511 0.5165 0.8828
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0144 0.0189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0367 0.0483
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0007 0.0012
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0144 0.0189
Brugia malayi G protein-coupled receptor 0.0025 0.0144 0.0246
Onchocerca volvulus 0.0025 0.0144 0.036
Echinococcus granulosus g protein coupled receptor 0.0025 0.0144 0.018
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0238 0.0273
Loa Loa (eye worm) hypothetical protein 0.0035 0.0245 0.0407
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0113 0.1054 0.9936
Brugia malayi larval opioid receptor 0.0025 0.0144 0.0246
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0238 0.225
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.106 0.1394
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0147 0.1402 0.3679
Toxoplasma gondii exonuclease III APE 0.0019 0.0081 0.0768
Giardia lamblia Kinase, PLK 0.0114 0.106 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0144 0.0137
Schistosoma mansoni alpha-glucosidase 0.044 0.4429 0.5824
Trypanosoma cruzi PAB1-binding protein , putative 0.0084 0.0748 0.685
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0069 0.0001
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0143 0.0746
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0081 0.0121
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0146 0.0783
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0025 0.0144 0.0234
Echinococcus multilocularis allatostatin A receptor 0.0025 0.0144 0.0137
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0025 0.0144 0.0189
Onchocerca volvulus 0.0039 0.0284 0.0731
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0311 0.3097 0.8152
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.033 0.0425
Schistosoma mansoni biogenic amine receptor 0.0025 0.0144 0.0189
Schistosoma mansoni apoferritin-2 0.0027 0.0162 0.0212
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0175 0.023
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0025 0.0144 0.0189
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0284 0.0888
Loa Loa (eye worm) hypothetical protein 0.0126 0.1181 0.201
Echinococcus granulosus ferritin 0.0027 0.0162 0.0203
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0081 0.0097
Echinococcus granulosus microtubule associated protein 2 0.0747 0.7605 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0144 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0007 0.0012
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0368 0.0629
Trypanosoma brucei glucosidase, putative 0.0113 0.1054 0.9941
Echinococcus multilocularis sex peptide receptor 0.0025 0.0144 0.0137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0144 0.0137
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0143 0.0107
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0025 0.0144 0.0234
Loa Loa (eye worm) hypothetical protein 0.0039 0.0284 0.0474
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0146 0.067
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0284 0.0888
Loa Loa (eye worm) cytochrome P450 0.0018 0.0069 0.0106
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0025 0.0144 0.0137
Brugia malayi vesicular acetylcholine transporter unc-17 0.0311 0.3097 0.5294
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0025 0.0144 0.0246
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0124
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0144 0.0137
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0146 0.0241
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0081 0.0763
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0361 0.3814
Echinococcus granulosus neutral alpha glucosidase AB 0.0113 0.1054 0.1377
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0672 0.1137
Schistosoma mansoni amine GPCR 0.0025 0.0144 0.0189
Trichomonas vaginalis maltase-glucoamylase, putative 0.0113 0.1054 0.1686
Schistosoma mansoni importin beta-1 0.0031 0.0204 0.0268
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0284 0.2681
Echinococcus multilocularis somatostatin receptor 0.0025 0.0144 0.0137
Plasmodium vivax glutathione reductase, putative 0.01 0.0912 1
Echinococcus granulosus serotonin receptor 0.0025 0.0144 0.018
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0069 0.0654
Loa Loa (eye worm) hypothetical protein 0.0084 0.0748 0.1267
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0146 0.0241
Schistosoma mansoni hypothetical protein 0.0043 0.033 0.0434
Onchocerca volvulus 0.0025 0.0144 0.036
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0318 0.0411
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0175 0.023
Echinococcus multilocularis neuropeptide receptor A26 0.0025 0.0144 0.0137
Schistosoma mansoni coup transcription factor 0.0012 0.0007 0.0009
Trichomonas vaginalis alpha-glucosidase, putative 0.0113 0.1054 0.1686
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0144 0.0137
Echinococcus granulosus cpg binding protein 0.0037 0.026 0.0333
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Echinococcus multilocularis expressed protein 0.0027 0.0162 0.0154
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0175 0.0288
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0069 0.0001
Plasmodium falciparum glutathione reductase 0.01 0.0912 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0175 0.1073
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0144 0.0189
Echinococcus multilocularis G-protein coupled receptor, putative 0.0025 0.0144 0.0137
Schistosoma mansoni hypothetical protein 0.0038 0.027 0.0355
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Plasmodium vivax JmjC domain containing protein 0.0028 0.0175 0.1723
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0175 0.1654
Onchocerca volvulus 0.0026 0.0146 0.0367
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0318 0.0543
Echinococcus granulosus histone acetyltransferase KAT2B 0.0154 0.1469 0.1923
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0318 0.242
Brugia malayi RNA binding protein 0.0076 0.0672 0.1148
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.0175 0.1663
Schistosoma mansoni survival motor neuron protein 0.005 0.0394 0.0517
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0238 0.0231
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0238 0.0408
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0239 0.0398
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Plasmodium falciparum thioredoxin reductase 0.01 0.0912 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0124
Brugia malayi putative neuropeptide receptor 0.0025 0.0144 0.0246
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0253 0.2496 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0318 0.0411
Schistosoma mansoni hypothetical protein 0.0025 0.0144 0.0189
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0238 0.0313
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Loa Loa (eye worm) hypothetical protein 0.0039 0.0284 0.0474
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0144 0.0137
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0238 0.0304
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0007 0.0009
Schistosoma mansoni alpha-1 adrenergic receptor 0.0025 0.0144 0.0189
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0069 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0146 0.025
Schistosoma mansoni ferritin 0.0027 0.0162 0.0212
Schistosoma mansoni ap endonuclease 0.0019 0.0081 0.0106
Loa Loa (eye worm) hypothetical protein 0.0028 0.0175 0.0288
Schistosoma mansoni amine GPCR 0.0025 0.0144 0.0189
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.06 0.5696
Brugia malayi Cytochrome P450 family protein 0.0018 0.0069 0.0118
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0079 0.0032
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0042 0.0318 0.2512
Echinococcus granulosus allatostatin A receptor 0.0025 0.0144 0.018
Schistosoma mansoni cpg binding protein 0.0035 0.0239 0.0315
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0144 0.0189
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0025 0.0144 0.0137
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0069 0.0001
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0245 0.0407
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0081 0.0126
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0162 0.0938
Echinococcus granulosus tachykinin peptides receptor 99D 0.0025 0.0144 0.018
Echinococcus granulosus g-protein coupled receptor 0.0025 0.0144 0.018
Echinococcus granulosus tar DNA binding protein 0.0076 0.0672 0.0874
Loa Loa (eye worm) hypothetical protein 0.0126 0.1181 0.201
Onchocerca volvulus 0.0039 0.0284 0.0731
Echinococcus multilocularis peregrin 0.0039 0.0285 0.0278
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0025 0.0144 0.0137
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0113 0.1054 0.1686
Schistosoma mansoni hypothetical protein 0.0047 0.0368 0.0484
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0144 0.0137
Plasmodium vivax thioredoxin reductase, putative 0.01 0.0912 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0245 0.0238
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0238 0.0526
Trichomonas vaginalis sucrase-isomaltase, putative 0.0113 0.1054 0.1686
Echinococcus multilocularis dro:myosuppressin receptor 0.0025 0.0144 0.0137
Schistosoma mansoni ferritin 0.0027 0.0162 0.0212
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0007 0.0009
Brugia malayi Glycosyl hydrolases family 31 protein 0.0511 0.5165 0.8829
Schistosoma mansoni neuropeptide receptor 0.0025 0.0144 0.0189
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0144 0.018
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0238 0.2432
Loa Loa (eye worm) hypothetical protein 0.0147 0.1402 0.2387
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Brugia malayi hypothetical protein 0.0025 0.0144 0.0246
Brugia malayi putative neuropeptide receptor NPR1 0.0025 0.0144 0.0246
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0144 0.018
Onchocerca volvulus 0.0016 0.0046 0.0102
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0081 0.0051
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0144 0.0137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0144 0.0137
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0361 0.0466
Echinococcus multilocularis snurportin 1 0.0333 0.3327 0.3322
Echinococcus granulosus neuropeptide s receptor 0.0025 0.0144 0.018
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0245 0.2505
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0144 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0144 0.0137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0367 0.036
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0146 0.032
Echinococcus multilocularis GPCR, family 2 0.0047 0.0368 0.0361
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0007 0.0012
Echinococcus granulosus sex peptide receptor 0.0025 0.0144 0.018
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0284 0.0486
Trichomonas vaginalis glucosylceramidase, putative 0.0399 0.4008 0.6808
Onchocerca volvulus 0.0025 0.0144 0.036
Entamoeba histolytica hypothetical protein 0.0043 0.033 0.2545
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Trichomonas vaginalis glucosylceramidase, putative 0.0379 0.3797 0.6442
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0124
Mycobacterium tuberculosis Probable reductase 0.0228 0.2233 0.8919
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.01 0.0912 0.3476
Brugia malayi beta-lactamase family protein 0.0039 0.0284 0.0486
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0284 0.0888
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0144 0.018
Brugia malayi nuclear hormone receptor 0.0012 0.0007 0.0012
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0238 0.1711
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0311 0.3097 0.5288
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Echinococcus multilocularis neuropeptide FF receptor 2 0.0025 0.0144 0.0137
Echinococcus multilocularis cpg binding protein 0.0037 0.026 0.0253
Trichomonas vaginalis glucosylceramidase, putative 0.0578 0.585 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.106 0.1812
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0025 0.0144 0.0189
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0146 0.0783
Schistosoma mansoni glutaminase 0.033 0.3292 0.4329
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0284 0.0277
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.106 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0007 0.0012
Onchocerca volvulus 0.0035 0.0239 0.0613
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0025 0.0144 0.0234
Brugia malayi Bromodomain containing protein 0.0039 0.0285 0.0487
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0175 0.023
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0007 0.0009
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.2394 0.3141
Mycobacterium ulcerans hypothetical protein 0.0039 0.0284 0.0668
Leishmania major hypothetical protein, conserved 0.0039 0.0284 0.2172
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0284 0.0374
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0144 0.0189
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0284 0.0668
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0025 0.0144 0.0189
Loa Loa (eye worm) hypothetical protein 0.0243 0.2394 0.4084
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0069 0.0001
Schistosoma mansoni amine GPCR 0.0025 0.0144 0.0189
Brugia malayi hypothetical protein 0.0043 0.033 0.0564
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0007 0.0012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0368 0.0361
Echinococcus granulosus neuropeptide FF receptor 2 0.0025 0.0144 0.018
Onchocerca volvulus 0.0025 0.0144 0.036
Schistosoma mansoni opsin-like receptor 0.0025 0.0144 0.0189
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Brugia malayi AKH receptor 0.0025 0.0144 0.0246
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0318 0.0411
Echinococcus granulosus g protein coupled receptor 0.0025 0.0144 0.018
Brugia malayi beta-lactamase family protein 0.0039 0.0284 0.0486
Brugia malayi follicle stimulating hormone receptor 0.0025 0.0144 0.0246
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0144 0.0137
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0069 0.0001
Brugia malayi hypothetical protein 0.0025 0.0144 0.0246
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0245 0.2324
Onchocerca volvulus 0.0025 0.0144 0.036
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0321 0.3364
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0238 0.2432
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0007 0.0009
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1371 0.2334
Echinococcus multilocularis serotonin receptor 0.0025 0.0144 0.0137
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0175 0.023
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0321 0.2457
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0284 0.2945
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0284 0.0888
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.033 0.0434
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0284 0.0887
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0284 0.0352
Loa Loa (eye worm) beta-lactamase 0.0039 0.0284 0.0474
Schistosoma mansoni neuropeptide receptor 0.0025 0.0144 0.0189
Loa Loa (eye worm) thioredoxin reductase 0.01 0.0912 0.1549
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0238 1
Brugia malayi PHD-finger family protein 0.0035 0.0245 0.0419
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0025 0.0144 0.0137
Schistosoma mansoni amine GPCR 0.0025 0.0144 0.0189
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1371 0.2334
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0238 0.1711
Trichomonas vaginalis glucosylceramidase, putative 0.0399 0.4008 0.6808
Echinococcus granulosus vesicular acetylcholine transporter 0.0311 0.3097 0.4066
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0079 0.0646
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0025 0.0144 0.0189
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0025 0.0144 0.018
Echinococcus multilocularis ferritin 0.0027 0.0162 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0379 0.3797 0.6442
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0067 0.0571 0.0976
Brugia malayi Serotonin receptor 0.0025 0.0144 0.0246
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0069 0.0001
Brugia malayi jmjC domain containing protein 0.0179 0.1735 0.2967
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0318 0.0411
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0284 0.0888
Brugia malayi PHD-finger family protein 0.0013 0.002 0.0035
Echinococcus multilocularis microtubule associated protein 2 0.0747 0.7605 0.7603
Brugia malayi Cytochrome P450 family protein 0.0027 0.0162 0.0277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0144 0.0189
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0047 0.0368 0.0618
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0081 0.0663
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0284 0.2172
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0361 0.343
Schistosoma mansoni vesicular acetylcholine transporter 0.0311 0.3097 0.4072
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0069 0.0001
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0025 0.0144 0.0189
Echinococcus granulosus 7TM GPCR rhodopsin 0.0025 0.0144 0.018
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0284 0.0364
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0025 0.0144 0.0137
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0253 0.2496 1
Onchocerca volvulus 0.0025 0.0144 0.036
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0144 0.0137
Schistosoma mansoni jumonji/arid domain-containing protein 0.0109 0.1005 0.1321
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0025 0.0144 0.0234
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.1421 0.2429
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0672 0.0883
Entamoeba histolytica hypothetical protein 0.0043 0.033 0.2545
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0038 0.027 0.0346
Schistosoma mansoni ferritin light chain 0.0027 0.0162 0.0212
Brugia malayi Melatonin receptor type 1A 0.0025 0.0144 0.0246
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0069 0.0081
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4985 0.4982
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0081 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0465 0.0665
Loa Loa (eye worm) acetyltransferase 0.0158 0.1514 0.258
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.106 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0238
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0162 0.0265
Mycobacterium leprae Probable lipase LipE 0.0039 0.0284 0.0887
Echinococcus granulosus g protein coupled receptor 0.0025 0.0144 0.018
Brugia malayi Thioredoxin reductase 0.01 0.0912 0.1559
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0113 0.1054 0.9936
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0672 0.0883
Plasmodium falciparum importin beta, putative 0.0031 0.0204 0.2044
Onchocerca volvulus 0.0025 0.0144 0.036
Onchocerca volvulus 0.0025 0.0144 0.036
Leishmania major hypothetical protein, conserved 0.0084 0.0748 0.685
Brugia malayi hypothetical protein 0.0025 0.0144 0.0246
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0007 0.0009
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0069 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0007 0.0012
Leishmania major hypothetical protein, conserved 0.0028 0.0175 0.1073
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0113 0.1054 0.1686
Schistosoma mansoni hypothetical protein 0.0035 0.0245 0.0322
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0245 0.2324
Schistosoma mansoni cpg binding protein 0.0037 0.026 0.0342
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Brugia malayi glutaminase DH11.1 0.033 0.3292 0.5628
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0179 0.1735 0.1729
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0025 0.0144 0.036
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0143 0.0107
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0144 0.0189
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0361 0.343
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.106 0.1697
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0175 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0144 0.0189
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0144 0.018
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0238 0.1711
Brugia malayi jmjC domain containing protein 0.0028 0.0175 0.03
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0023
Schistosoma mansoni ferritin 0.0027 0.0162 0.0212
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0474 0.0799
Trichomonas vaginalis glucosylceramidase, putative 0.0578 0.585 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0144 0.018
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0144 0.018
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0238 0.1711
Loa Loa (eye worm) hypothetical protein 0.0077 0.0682 0.1154
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0238 0.1711
Schistosoma mansoni cpg binding protein 0.0037 0.026 0.0342
Trichomonas vaginalis glucosylceramidase, putative 0.0379 0.3797 0.6442
Brugia malayi Importin beta-1 subunit 0.0031 0.0204 0.0348
Schistosoma mansoni hypothetical protein 0.0047 0.0368 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0007 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.106 0.1697
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0089 0.0117
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0238 0.1711
Mycobacterium tuberculosis Probable dehydrogenase 0.0228 0.2233 0.8919
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0387 0.05
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0144 0.0189
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0144 0.018
Schistosoma mansoni neuropeptide receptor 0.0025 0.0144 0.0189
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0238 0.2432
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0069 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0144 0.0189
Schistosoma mansoni kinase 0.0058 0.048 0.0631
Schistosoma mansoni cytochrome P450 0.0018 0.0069 0.0091
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0387 0.038
Echinococcus granulosus GPCR family 2 0.0047 0.0368 0.0475
Echinococcus granulosus lysosomal alpha glucosidase 0.0511 0.5165 0.6788
Echinococcus multilocularis lysine specific demethylase 5A 0.0107 0.0984 0.0978
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0175 0.0221
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0162 0.1528
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0124
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0204 0.1923
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0007 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0284 0.2172
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0367 0.0628
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0632 0.107
Mycobacterium ulcerans glutaminase 0.033 0.3292 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0144 0.018
Brugia malayi ecdysteroid receptor 0.0012 0.0007 0.0012
Brugia malayi nuclear receptor NHR-88 0.0012 0.0007 0.0012
Schistosoma mansoni ferritin 0.0027 0.0162 0.0212
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0144 0.0137
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.0912 0.1191
Loa Loa (eye worm) glutaminase 2 0.033 0.3292 0.5623
Brugia malayi hypothetical protein 0.0025 0.0144 0.0246
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0196 0.0248
Trypanosoma brucei PAB1-binding protein , putative 0.0084 0.0748 0.7055
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0238 0.225
Brugia malayi hypothetical protein 0.0054 0.0441 0.0753
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0079 0.0646
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0175 0.0288
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0146 0.0321
Loa Loa (eye worm) jmjC domain-containing protein 0.0109 0.1005 0.1707
Onchocerca volvulus 0.0025 0.0144 0.036
Schistosoma mansoni jumonji/arid domain-containing protein 0.0109 0.1005 0.1321
Trypanosoma cruzi PAB1-binding protein , putative 0.0084 0.0748 0.685
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0162 0.0288
Echinococcus multilocularis orexin receptor type 2 0.0025 0.0144 0.0137
Echinococcus granulosus neuropeptide receptor 0.0025 0.0144 0.018
Leishmania major alpha glucosidase II subunit, putative 0.0113 0.1054 0.9937
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0368 0.0475
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0249 0.2456 0.9836
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0162 0.0265
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0238 0.07
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0109 0.0187
Onchocerca volvulus 0.0025 0.0144 0.036
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Mycobacterium ulcerans lipase LipD 0.0039 0.0284 0.0668
Brugia malayi N-terminal motif family protein 0.0147 0.1402 0.2396
Onchocerca volvulus 0.0025 0.0144 0.036
Plasmodium falciparum ataxin-2 like protein, putative 0.0084 0.0748 0.8152
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0146 0.0241
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0238 0.225
Brugia malayi hypothetical protein 0.0025 0.0144 0.0246
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0158 0.1514 0.1508
Onchocerca volvulus 0.0039 0.0284 0.0731
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0361 0.0486
Schistosoma mansoni hypothetical protein 0.005 0.0394 0.0517
Trichomonas vaginalis glucosylceramidase, putative 0.0578 0.585 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.0912 0.0906
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0007 0.0012
Echinococcus granulosus neuropeptide receptor A26 0.0025 0.0144 0.018
Brugia malayi sulfakinin receptor protein 0.0025 0.0144 0.0246
Loa Loa (eye worm) hypothetical protein 0.0042 0.0318 0.0532
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0318 0.0411
Brugia malayi neuropeptide F receptor 0.0025 0.0144 0.0246
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0027 0.0162 0.0382
Brugia malayi glutathione reductase 0.01 0.0912 0.1559
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0025 0.0144 0.0189
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0368 0.0618
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0025 0.0144 0.0246
Echinococcus granulosus snurportin 1 0.0333 0.3327 0.4369
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0144 0.0189
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0144 0.018
Onchocerca volvulus 0.0025 0.0144 0.036
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0144 0.018
Loa Loa (eye worm) hypothetical protein 0.0102 0.0934 0.1586
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0196 0.0189
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0333 0.3327 0.5681
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.2394 0.2388
Plasmodium falciparum ataxin-2 like protein, putative 0.0084 0.0748 0.8152
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0144 0.0189
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0025 0.0144 0.0246
Loa Loa (eye worm) RNA binding protein 0.0076 0.0672 0.1137
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0144 0.0137
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0175 0.0168
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0228 0.2233 0.8919
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0025 0.0144 0.018
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0025 0.0144 0.018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0144 0.0189
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0027 0.0162 0.0383
Brugia malayi Dopamine receptor 0.0025 0.0144 0.0246
Schistosoma mansoni hypothetical protein 0.0025 0.0144 0.0189
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0144 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0146 0.0241
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0025 0.0144 0.0189
Echinococcus granulosus G protein coupled receptor 139 0.0025 0.0144 0.018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0368 0.0475
Echinococcus multilocularis lysosomal alpha glucosidase 0.0511 0.5165 0.5161
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.106 0.1802
Onchocerca volvulus Neuropeptide F receptor homolog 0.0025 0.0144 0.036
Trypanosoma brucei trypanothione reductase 0.01 0.0912 0.8607
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0067 0.0571 0.2069
Schistosoma mansoni hypothetical protein 0.0018 0.0069 0.0091
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0175 0.1073
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0204 0.1923
Schistosoma mansoni apoferritin-2 0.0027 0.0162 0.0212
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.106 0.1697
Brugia malayi neuropeptide F receptor 0.0025 0.0144 0.0246
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0284 0.0668
Brugia malayi GnHR receptor homolog 0.0025 0.0144 0.0246
Trichomonas vaginalis alpha-glucosidase, putative 0.0113 0.1054 0.1686
Brugia malayi hypothetical protein 0.0025 0.0144 0.0246
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0007 0.0012
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0144 0.0137
Loa Loa (eye worm) melatonin receptor type 1A 0.0025 0.0144 0.0234
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0038 0.027 0.0263
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0144 0.018
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0175 0.0221
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Mycobacterium tuberculosis Conserved protein 0.0039 0.0284 0.0888
Brugia malayi Glycosyl hydrolases family 31 protein 0.0113 0.1054 0.1801
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0027 0.0162 0.0383
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0124
Mycobacterium tuberculosis Conserved protein 0.0039 0.0284 0.0888
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.106 0.1385
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0144 0.0234
Schistosoma mansoni ap endonuclease 0.0019 0.0081 0.0106
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0146 0.067
Schistosoma mansoni hypothetical protein 0.0333 0.3327 0.4374
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0238 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0069 0.0001
Brugia malayi jmjC domain containing protein 0.0028 0.0175 0.03
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0144 0.0234
Onchocerca volvulus Huntingtin homolog 0.0126 0.1181 0.3098
Trichomonas vaginalis glucosylceramidase, putative 0.0379 0.3797 0.6442
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0144 0.0137
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0146 0.025
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Brugia malayi hypothetical protein 0.0243 0.2394 0.4092
Mycobacterium ulcerans bacterioferritin BfrB 0.0027 0.0162 0.0288
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0368 0.0361
Onchocerca volvulus 0.0025 0.0144 0.036
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0238 0.2432
Trichomonas vaginalis glucosylceramidase, putative 0.0578 0.585 1
Brugia malayi hypothetical protein 0.0025 0.0144 0.0246
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1054 0.9937
Toxoplasma gondii LsmAD domain-containing protein 0.0084 0.0748 0.7097
Brugia malayi G-protein coupled receptor 0.0025 0.0144 0.0246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0367 0.0483
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0025 0.0144 0.0246
Echinococcus granulosus importin subunit beta 1 0.0031 0.0204 0.0259
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0284 0.0352
Loa Loa (eye worm) hypothetical protein 0.0039 0.0284 0.0474
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0144 0.0137
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0081 0.0121
Echinococcus granulosus hypothetical protein 0.0025 0.0144 0.018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0367 0.036
Schistosoma mansoni growth hormone secretagogue receptor 0.0025 0.0144 0.0189
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0672 0.1137
Schistosoma mansoni alpha glucosidase 0.0113 0.1054 0.1385
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0367 0.0616
Echinococcus granulosus orexin receptor type 2 0.0025 0.0144 0.018
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0175 0.0288
Schistosoma mansoni opsin-like receptor 0.0025 0.0144 0.0189
Mycobacterium tuberculosis Conserved protein 0.0039 0.0284 0.0888
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0238 0.0526
Schistosoma mansoni myosin xvIII 0.0025 0.0144 0.0189
Echinococcus multilocularis neuropeptide s receptor 0.0025 0.0144 0.0137
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0146 0.0783
Brugia malayi hypothetical protein 0.0025 0.0144 0.0246
Echinococcus granulosus somatostatin receptor 0.0025 0.0144 0.018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0284 0.0474
Brugia malayi Cytochrome P450 family protein 0.0027 0.0162 0.0277
Entamoeba histolytica hypothetical protein 0.0043 0.033 0.2545
Echinococcus granulosus peptide allatostatin:somatostatin 0.0025 0.0144 0.018
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0144 0.0137
Brugia malayi Dopamine receptor protein 2 0.0025 0.0144 0.0246
Loa Loa (eye worm) hypothetical protein 0.0149 0.1421 0.2419
Schistosoma mansoni microtubule-associated protein tau 0.0747 0.7605 1
Echinococcus granulosus peregrin 0.0039 0.0285 0.0365
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0641 0.0843
Trypanosoma cruzi trypanothione reductase, putative 0.01 0.0912 0.851
Schistosoma mansoni amine GPCR 0.0025 0.0144 0.0189
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0284 0.0352
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0367 0.0474
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.0571 0.1557
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0484 0.0816
Brugia malayi steroid hormone receptor 0.0012 0.0007 0.0012
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0025 0.0144 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0007 0.0012
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.1421 0.2429
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0238 0.1711
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0238 0.1711
Onchocerca volvulus Alhambra homolog 0.0035 0.0245 0.0627
Leishmania major importin beta-1 subunit, putative 0.0025 0.0143 0.0746
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0144 0.018
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0069 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0144 0.018
Trypanosoma brucei glycosyl hydrolase-like protein 0.0042 0.0318 0.2998
Brugia malayi Serotonin receptor 0.0025 0.0144 0.0246
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0069 0.0001
Schistosoma mansoni hypothetical protein 0.0047 0.0368 0.0484
Treponema pallidum bacterioferrin (TpF1) 0.0027 0.0162 0.5123
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0007 0.0009
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0069 0.0001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0144 0.0245
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0144 0.018
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0146 0.0241
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.106 0.2777
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0321 0.2457
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0245 0.0322
Echinococcus multilocularis 0.0018 0.0069 0.0062
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0144 0.018
Schistosoma mansoni alpha-glucosidase 0.044 0.4429 0.5824
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0162 0.0265
Plasmodium vivax ataxin-2 like protein, putative 0.0084 0.0748 0.8152
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Loa Loa (eye worm) hypothetical protein 0.0039 0.0284 0.0474
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0175 0.0168
Echinococcus granulosus phd:f box containing protein 0.0028 0.0175 0.0221
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0238 0.1711
Trichomonas vaginalis glutaminase, putative 0.033 0.3292 0.5567
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Mycobacterium tuberculosis Probable oxidoreductase 0.0253 0.2496 1
Onchocerca volvulus 0.0025 0.0144 0.036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0238 0.1711
Trichomonas vaginalis glucosylceramidase, putative 0.0578 0.585 1
Echinococcus multilocularis g-protein coupled receptor 0.0025 0.0144 0.0137
Trichomonas vaginalis glucosylceramidase, putative 0.0578 0.585 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0394 0.0673
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0245 0.0313
Loa Loa (eye worm) hypothetical protein 0.0039 0.0284 0.0474
Echinococcus multilocularis serotonin receptor 0.0025 0.0144 0.0137
Brugia malayi ORL1-like opioid receptor 0.0025 0.0144 0.0246
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0238 0.1711
Trichomonas vaginalis glucosylceramidase, putative 0.0379 0.3797 0.6442
Treponema pallidum NADH oxidase 0.0035 0.0238 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0284 0.0374
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0367 0.0474
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0146 0.025
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0175 0.0168
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0578 0.585 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.033 0.0323
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0069 0.0001
Schistosoma mansoni adenoreceptor 0.0025 0.0144 0.0189
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0318 0.0411
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0146 0.0241
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0204 0.0197
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0578 0.585 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0146 0.067
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0672 0.0665
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0146 0.0321
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0144 0.0137
Entamoeba histolytica hypothetical protein 0.0025 0.0143 0.0632
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0238 0.1609
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0204 0.1935
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0238 0.1711
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1054 0.9937
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0367 0.0483
Echinococcus granulosus lysine specific demethylase 5A 0.0109 0.1005 0.1313
Giardia lamblia PHD finger protein 15 0.0035 0.0245 0.1675
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.106 0.1697
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0042 0.0318 0.0819
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0144 0.0137
Toxoplasma gondii ABC1 family protein 0.0039 0.0284 0.2696
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0007 0.0012
Schistosoma mansoni jumonji domain containing protein 0.0156 0.149 0.196
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0144 0.0234
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0162 0.0938
Schistosoma mansoni neuropeptide receptor 0.0025 0.0144 0.0189
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0175 0.1723
Trichomonas vaginalis ferritin, putative 0.0027 0.0162 0.014
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0025 0.0144 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0007 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.106 0.1697
Leishmania major cytochrome p450-like protein 0.0027 0.0162 0.0938
Brugia malayi jmjC domain containing protein 0.0028 0.0175 0.03
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0144 0.018
Brugia malayi G protein-coupled receptor F59B2.13 0.0025 0.0144 0.0246
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Echinococcus granulosus 7tm_1 domain containing protein 0.0025 0.0144 0.018
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0069 0.0001
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0067 0.0571 0.075
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0361 0.0486
Schistosoma mansoni neuropeptide f receptor 76f 0.0025 0.0144 0.0189
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0007 0.0012
Brugia malayi Cytochrome P450 family protein 0.0057 0.0474 0.081
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0284 0.0888
Brugia malayi TAR-binding protein 0.0076 0.0672 0.1148
Schistosoma mansoni biogenic amine receptor 0.0025 0.0144 0.0189
Echinococcus granulosus fmrfamide receptor 0.0025 0.0144 0.018
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.0571 0.0564
Echinococcus granulosus alpha 1A adrenergic receptor 0.0025 0.0144 0.018
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0113 0.1054 0.1791
Trypanosoma brucei polo-like protein kinase 0.0114 0.106 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0113 0.1054 0.1686
Echinococcus granulosus expressed protein 0.0027 0.0162 0.0203
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0318 0.0411
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0238 0.0273
Entamoeba histolytica hypothetical protein 0.0043 0.033 0.2545
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0228 0.2233 0.8918
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0143 0.0107
Schistosoma mansoni histamine h1 receptor 0.0025 0.0144 0.0189
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0238 0.0526
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0144 0.0234
Brugia malayi Tachykinin-like peptides receptor 99D 0.0025 0.0144 0.0246
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0158 0.1514 0.1991
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0025 0.0144 0.0137
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0025 0.0144 0.0137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0144 0.0137
Mycobacterium ulcerans bacterioferritin BfrA 0.0027 0.0162 0.0288
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0368 0.0629
Loa Loa (eye worm) hypothetical protein 0.0031 0.0204 0.0337
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0238 1
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0934 0.1596
Echinococcus granulosus neuropeptide receptor 0.0025 0.0144 0.018
Trichomonas vaginalis alpha-glucosidase, putative 0.0113 0.1054 0.1686
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0672 0.0883
Brugia malayi acetyltransferase, GNAT family protein 0.0158 0.1514 0.2589
Brugia malayi cytochrome P450 0.0018 0.0069 0.0118
Brugia malayi beta-lactamase 0.0039 0.0284 0.0486
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.106 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0069 0.065
Echinococcus multilocularis vesicular acetylcholine transporter 0.0311 0.3097 0.3092
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0144 0.0137
Leishmania major glycosyl hydrolase-like protein 0.0042 0.0318 0.2512
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0007 0.0012
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0113 0.1054 1
Plasmodium falciparum thioredoxin reductase 0.0035 0.0238 0.2432
Schistosoma mansoni hypothetical protein 0.0025 0.0144 0.0189
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0025 0.0144 0.0189
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0144 0.0189
Brugia malayi Dopamine receptor protein 1 0.0025 0.0144 0.0246
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0144 0.018
Brugia malayi MH2 domain containing protein 0.0144 0.1371 0.2343
Trichomonas vaginalis alpha-glucosidase, putative 0.0113 0.1054 0.1686
Echinococcus granulosus dro:myosuppressin receptor 0.0025 0.0144 0.018
Mycobacterium ulcerans beta-lactamase 0.0039 0.0284 0.0668
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0069 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0079 0.0045
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.106 0.1053
Trichomonas vaginalis glucosylceramidase, putative 0.0379 0.3797 0.6442
Brugia malayi RNA, U transporter 1 0.0089 0.0799 0.1366
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.0175 0.1663
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0027 0.0162 0.5123
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0228 0.2233 0.8919
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Loa Loa (eye worm) hypothetical protein 0.0028 0.0175 0.0288
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0007 0.0009
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0238 0.225
Brugia malayi hypothetical protein 0.0084 0.0748 0.1278
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0284 0.0352
Onchocerca volvulus 0.0296 0.2937 0.773
Brugia malayi jmjC domain containing protein 0.0109 0.1005 0.1717
Trichomonas vaginalis glucosylceramidase, putative 0.0379 0.3797 0.6442
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0081 0.0121
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0146 0.032
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0081 0.0663
Onchocerca volvulus 0.0025 0.0144 0.036
Brugia malayi G-protein coupled receptor 0.0025 0.0144 0.0246
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Onchocerca volvulus Glucosylceramidase homolog 0.0379 0.3797 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0144 0.0137
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0069 0.0001
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0081 0.0138
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0144 0.0189
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0042 0.0318 0.2512
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0144 0.0245
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0672 0.1148
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0069 0.0001
Echinococcus multilocularis neutral alpha glucosidase AB 0.0113 0.1054 0.1047
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Onchocerca volvulus 0.0025 0.0144 0.036
Brugia malayi jmjC domain containing protein 0.0028 0.0175 0.03
Loa Loa (eye worm) glutaminase 0.033 0.3292 0.5623
Echinococcus multilocularis lysosomal alpha glucosidase 0.0511 0.5165 0.5161
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0025 0.0144 0.0246
Mycobacterium ulcerans hypothetical protein 0.0026 0.0146 0.0241
Schistosoma mansoni biogenic amine receptor 0.0025 0.0144 0.0189
Brugia malayi hypothetical protein 0.0126 0.1181 0.202
Onchocerca volvulus 0.005 0.0394 0.1019
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0081 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0672 0.0883
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0069 0.0001
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0175 0.023
Echinococcus multilocularis G protein coupled receptor 139 0.0025 0.0144 0.0137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.1421 0.2419
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0238
Schistosoma mansoni hypothetical protein 0.0047 0.0368 0.0484
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0146 0.0241
Plasmodium vivax importin-beta 2, putative 0.0031 0.0204 0.2044
Brugia malayi hypothetical protein 0.0025 0.0144 0.0246
Schistosoma mansoni opsin-like receptor 0.0025 0.0144 0.0189
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0144 0.018
Plasmodium falciparum phd finger protein, putative 0.0035 0.0245 0.2505
Plasmodium falciparum glutathione reductase 0.0035 0.0238 0.2432
Schistosoma mansoni hypothetical protein 0.0102 0.0934 0.1228
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0234
Schistosoma mansoni hypothetical protein 0.0494 0.4985 0.6555
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4985 0.6552
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0007 0.0012
Brugia malayi hypothetical protein 0.0025 0.0144 0.0246
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0465 0.0665
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.106 0.1697
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0318 0.0411
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0067 0.0571 0.5065
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0238 0.1711
Loa Loa (eye worm) TYRA-2 protein 0.0025 0.0144 0.0234
Toxoplasma gondii thioredoxin reductase 0.01 0.0912 0.8658
Onchocerca volvulus 0.0025 0.0144 0.036
Brugia malayi CXXC zinc finger family protein 0.0035 0.0239 0.0409
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0144 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0672 0.0883
Trichomonas vaginalis esterase, putative 0.0039 0.0284 0.0352
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0228 0.2233 0.8919
Schistosoma mansoni ferritin light chain 0.0027 0.0162 0.0212
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.0571 0.0742
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0228 0.2233 0.8919
Brugia malayi RE15519p 0.0025 0.0144 0.0246
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0144 0.018
Onchocerca volvulus Huntingtin homolog 0.0126 0.1181 0.3098
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0238
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.106 0.1697
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0284 0.0352
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0253 0.2496 1
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0238 0.2263
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0238 0.2263
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0284 0.0474
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0144 0.0137
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0175 0.0221
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0284 0.0888

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 3.3587 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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