Detailed information for compound 765248

Basic information

Technical information
  • TDR Targets ID: 765248
  • Name: 3-[(4-chlorophenyl)methyl]-6-ethoxy-2,4-dihyd ro-1,3-benzoxazine
  • MW: 303.783 | Formula: C17H18ClNO2
  • H donors: 0 H acceptors: 0 LogP: 4.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc2c(c1)CN(CO2)Cc1ccc(cc1)Cl
  • InChi: 1S/C17H18ClNO2/c1-2-20-16-7-8-17-14(9-16)11-19(12-21-17)10-13-3-5-15(18)6-4-13/h3-9H,2,10-12H2,1H3
  • InChiKey: RRQWNGSEMNJXDW-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-(4-chlorobenzyl)-6-ethoxy-2,4-dihydro-1,3-benzoxazine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 1 Starlite/ChEMBL No references
Plasmodium falciparum mitogen-activated protein kinase 2 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 6 Starlite/ChEMBL No references
Plasmodium falciparum protein kinase 7 Starlite/ChEMBL No references
Leishmania mexicana glucose transporter, lmgt2 Starlite/ChEMBL No references
Plasmodium falciparum calcium-dependent protein kinase 1 Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Calcium-dependent protein kinase 4 Starlite/ChEMBL No references
Plasmodium falciparum (isolate 3D7) Proline--tRNA ligase Starlite/ChEMBL No references
Plasmodium falciparum hexose transporter Starlite/ChEMBL No references
Plasmodium falciparum lysine--tRNA ligase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Brugia malayi Bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma cruzi lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum IPR000924,Glutamyl-tRNA synthetase, class Ic;IPR001412,Aminoacyl-tRNA synthetase, class I,domain-containing Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Cryptosporidium parvum lysyl-tRNA synthetase (NOB+tRNA synthetase) Get druggable targets OG5_126972 All targets in OG5_126972
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania major glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Chlamydia trachomatis lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania infantum glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Cryptosporidium parvum proline-tRNA synthetase; class II aaRS (ybak RNA binding domain plus tRNA synthetase) Get druggable targets OG5_127154 All targets in OG5_127154
Giardia lamblia Prolyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Brugia malayi bifunctional aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus granulosus lysyl tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Babesia bovis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Brugia malayi Sugar transporter family protein Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126972 All targets in OG5_126972
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 1, putative Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Leishmania braziliensis lmgt2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Candida albicans hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi hexose transporter, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Giardia lamblia Lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Neospora caninum protein kinase, PfPK7 homolog, putative Get druggable targets OG5_145294 All targets in OG5_145294
Plasmodium knowlesi proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani glucose transporter 1 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium berghei proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Loa Loa (eye worm) sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei gambiense lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum IPR005828,General substrate transporter,domain-containing Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum lysine--tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K07299 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans similar to S. cerevisiae YHR020W Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter 2A Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax proline--tRNA ligase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi protein kinase 7, putative Get druggable targets OG5_145294 All targets in OG5_145294
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma cruzi hexose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii facilitative glucose transporter GT1 Get druggable targets OG5_127135 All targets in OG5_127135
Neospora caninum Glucose transporter 1A, related Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Cryptosporidium parvum mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum expressed protein Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma brucei glucose transporter 1E Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania braziliensis lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium ulcerans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium vivax lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium vivax hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma congolense prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Mycobacterium leprae Probable prolyl tRNA synthetase ProS Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K01881 prolyl-tRNA synthetase [EC6.1.1.15], putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis solute carrier family 2, facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Theileria parva lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium yoelii lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense glucose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense glucose transporter,glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei gambiense prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani glucose transporter 3, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania infantum prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Theileria parva prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium berghei mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei protein kinase 6 Get druggable targets OG5_155179 All targets in OG5_155179
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum CMGC kinase, MAPK family, putative Get druggable targets OG5_138034 All targets in OG5_138034
Brugia malayi lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 3, putative Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma cruzi prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania braziliensis glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis Kars protein Get druggable targets OG5_126972 All targets in OG5_126972
Toxoplasma gondii protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Candida albicans lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum proline--tRNA ligase Get druggable targets OG5_127154 All targets in OG5_127154
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium knowlesi lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Plasmodium berghei lysine--tRNA ligase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania donovani lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii Ser/Thr protein kinase Get druggable targets OG5_145294 All targets in OG5_145294
Leishmania infantum lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Babesia bovis lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma japonicum ko:K07191 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Cryptosporidium hominis aminoacyl-tRNA synthetase Get druggable targets OG5_127154 All targets in OG5_127154
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 4, putative Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Leishmania major lysyl-tRNA synthetase, putative Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii putative sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Toxoplasma gondii lysine-tRNA ligase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania mexicana glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania braziliensis prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis prolyl-tRNA synthetase, putative Get druggable targets OG5_127154 All targets in OG5_127154
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni lysyl-tRNA synthetase Get druggable targets OG5_126972 All targets in OG5_126972
Leishmania major glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) Get druggable targets OG5_127154 All targets in OG5_127154
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) Get druggable targets OG5_126972 All targets in OG5_126972
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii cdk-related protein kinase 6-related Get druggable targets OG5_155179 All targets in OG5_155179
Echinococcus granulosus General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K04567 lysyl-tRNA synthetase, class II, putative Get druggable targets OG5_126972 All targets in OG5_126972
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127154 All targets in OG5_127154
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Theileria parva mitogen-activated protein kinase 2, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii mitogen-activated protein kinase 2 Get druggable targets OG5_138034 All targets in OG5_138034
Babesia bovis mitogen-activated protein kinase, putative Get druggable targets OG5_138034 All targets in OG5_138034
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_145294 All targets in OG5_145294
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium vivax CDK-related protein kinase 6, putative Get druggable targets OG5_155179 All targets in OG5_155179
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum protein kinase 7 Get druggable targets OG5_145294 All targets in OG5_145294
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative Get druggable targets OG5_138034 All targets in OG5_138034
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Cryptosporidium hominis hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Babesia bovis mitogen-activated protein kinase, putative Calcium-dependent protein kinase 4   528 aa 427 aa 23.4 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Calcium-dependent protein kinase 4   528 aa 468 aa 35.9 %
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase 7 343 aa 310 aa 25.2 %
Neospora caninum Calcium-dependent protein kinase, related Calcium-dependent protein kinase 4   528 aa 516 aa 35.5 %
Cryptosporidium hominis calmodulin-domain protein kinase 2 Calcium-dependent protein kinase 4   528 aa 468 aa 36.1 %
Leishmania braziliensis protein kinase, putative Calcium-dependent protein kinase 4   528 aa 490 aa 27.3 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 522 aa 25.5 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 29.0 %
Toxoplasma gondii calcium-dependent protein kinase CDPK9 Calcium-dependent protein kinase 4   528 aa 500 aa 34.2 %
Toxoplasma gondii calcium-dependent protein kinase CDPK6 Calcium-dependent protein kinase 4   528 aa 453 aa 34.0 %
Leishmania infantum protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Leishmania mexicana protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.2 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 527 aa 25.6 %
Cryptosporidium parvum hypothetical protein Calcium-dependent protein kinase 4   528 aa 463 aa 34.1 %
Entamoeba histolytica protein kinase, putative Calcium-dependent protein kinase 4   528 aa 429 aa 26.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 protein kinase 6 305 aa 338 aa 27.2 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 499 aa 29.3 %
Neospora caninum CAM kinase, CDPK family, putative Calcium-dependent protein kinase 4   528 aa 463 aa 32.0 %
Trypanosoma brucei glucose transporter, putative hexose transporter 504 aa 426 aa 22.3 %
Trypanosoma brucei gambiense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Trypanosoma brucei protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Leishmania donovani protein kinase, putative Calcium-dependent protein kinase 4   528 aa 486 aa 27.4 %
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 489 aa 28.8 %
Cryptosporidium hominis calcium-dependent protein kinase Calcium-dependent protein kinase 4   528 aa 502 aa 29.7 %
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative Calcium-dependent protein kinase 4   528 aa 524 aa 26.7 %
Leishmania major protein kinase, putative Calcium-dependent protein kinase 4   528 aa 488 aa 27.5 %
Theileria parva protein kinase, putative Calcium-dependent protein kinase 4   528 aa 507 aa 27.4 %
Cryptosporidium parvum calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands Calcium-dependent protein kinase 4   528 aa 501 aa 28.9 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 509 aa 25.5 %
Babesia bovis calcium-dependent protein kinase, putative Calcium-dependent protein kinase 4   528 aa 450 aa 30.2 %
Trypanosoma congolense protein kinase, putative Calcium-dependent protein kinase 4   528 aa 517 aa 27.9 %
Toxoplasma gondii calcium-dependent protein kinase CDPK2 Calcium-dependent protein kinase 4   528 aa 480 aa 36.9 %
Theileria parva calmodulin-domain protein kinase, putative Calcium-dependent protein kinase 4   528 aa 454 aa 31.9 %
Trypanosoma brucei glucose transporter, putative solute carrier family 2 (facilitated glucose transporter), member 1 492 aa 395 aa 23.5 %
Giardia lamblia Kinase, NEK Calcium-dependent protein kinase 4   528 aa 509 aa 19.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0475 0.0701
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0049 0.0049
Plasmodium falciparum protein kinase 7 0.0357 0.448 0.6612
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0059 0.0157
Entamoeba histolytica Ran family GTPase 0.0022 0.0187 0.0501
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0718 0.4031
Onchocerca volvulus 0.0035 0.0357 0.0529
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0394 0.0394
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0049 0.0055
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0059 0.0066
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0059 0.0061
Schistosoma mansoni hypothetical protein 0.0315 0.3948 0.444
Loa Loa (eye worm) sugar transporter 0.0126 0.1527 0.1583
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0039 0.0404 0.0455
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0059 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0084
Brugia malayi hypothetical protein 0.001 0.0032 0.0033
Schistosoma mansoni lamin 0.003 0.029 0.0326
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0039 0.0039
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0113 0.0117
Leishmania major C-8 sterol isomerase-like protein 0.037806 1 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0813 0.0843
Echinococcus granulosus lysine specific demethylase 5A 0.0096 0.1144 0.1286
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0157
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0238 0.0268
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0143 0.0148
Brugia malayi isocitrate dehydrogenase 0.0017 0.0132 0.0137
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0143 0.0148
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0718 0.2592
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0216 0.1211
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0204 0.1145
Onchocerca volvulus 0.0018 0.0136 0.017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0049 0.0051
Brugia malayi hypothetical protein 0.0018 0.0136 0.0141
Onchocerca volvulus 0.0018 0.0136 0.017
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0394 0.1053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.049 0.049
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0119 0.0267
Schistosoma mansoni sugar transporter 0.0018 0.0136 0.0153
Loa Loa (eye worm) hypothetical protein 0.0031 0.0311 0.0322
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0059 0.0087
Loa Loa (eye worm) hypothetical protein 0.0017 0.0129 0.0134
Mycobacterium ulcerans hypothetical protein 0.0023 0.0204 0.1145
Brugia malayi major facilitator superfamily protein 0.0018 0.0136 0.0141
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0136 0.0153
Schistosoma mansoni coup transcription factor 0.0011 0.0049 0.0055
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0132 0.0137
Mycobacterium ulcerans beta-lactamase 0.0035 0.0357 0.2003
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.002 0.017 0.0176
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0049 0.0049
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0136 0.0201
Entamoeba histolytica hypothetical protein 0.0012 0.0059 0.0157
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0049 0.0055
Trypanosoma cruzi C-8 sterol isomerase, putative 0.076 0.9646 1
Giardia lamblia Replication factor C, subunit 1 0.001 0.0032 0.0084
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0435 0.0451
Loa Loa (eye worm) hypothetical protein 0.0039 0.0404 0.0419
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0238 0.0268
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0224 0.0598
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.3744 1
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.002 0.017 0.0191
Onchocerca volvulus 0.0018 0.0136 0.017
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0129 0.0467
Schistosoma mansoni DNA helicase recq1 0.001 0.0039 0.0044
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0216 0.0576
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0204 0.1145
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0136 0.0364
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0136 0.112
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0411 0.1097
Plasmodium vivax sugar transporter, putative 0.0018 0.0136 0.0201
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0327 0.0339
Echinococcus granulosus chromobox protein 1 0.0071 0.0823 0.0926
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.0038 0.0394 0.0409
Loa Loa (eye worm) hypothetical protein 0.0472 0.5954 0.6173
Schistosoma mansoni DNA helicase recq5 0.001 0.0039 0.0044
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1527 0.1717
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.3744 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0327 0.0339
Echinococcus multilocularis solute carrier family 22 0.0018 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.037
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0059 0.0087
Echinococcus granulosus leucyl aminopeptidase 0.002 0.017 0.0191
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0093 0.0093
Plasmodium vivax importin-beta 2, putative 0.003 0.0287 0.0424
Loa Loa (eye worm) hypothetical protein 0.0103 0.1231 0.1276
Schistosoma mansoni hypothetical protein 0.0012 0.0059 0.0066
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.002 0.017 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0157
Trichomonas vaginalis hypothetical protein 0.0012 0.0059 0.0157
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0039 0.0405 0.0903
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0051
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.1 0.1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0117 0.0424
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0187 0.0194
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3744 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0204 0.1145
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0357 0.1288
Schistosoma mansoni DNA ligase IV 0.001 0.0032 0.0035
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0049 0.0055
Echinococcus multilocularis serotonin receptor 0.00909716 0 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0059 0.0157
Echinococcus multilocularis lamin 0.003 0.029 0.029
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0059 0.0061
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0287 0.0641
Entamoeba histolytica hypothetical protein 0.0024 0.0216 0.0576
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0143 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0049 0.0051
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0136 0.0766
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0032 0.0084
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0136 0.0141
Echinococcus granulosus nibrin 0.001 0.0032 0.0035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0086 0.0089
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0077 0.0206
Chlamydia trachomatis cytosol aminopeptidase 0.0102 0.1219 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0204 0.0545
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0059 0.0157
Plasmodium vivax CDK-related protein kinase 6, putative 0.0536 0.6775 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Brugia malayi PHD-finger family protein 0.001 0.0034 0.0035
Loa Loa (eye worm) hypothetical protein 0.003 0.0287 0.0298
Loa Loa (eye worm) hypothetical protein 0.0017 0.0129 0.0134
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0404 0.0404
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0404 0.0404
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0216 0.1771
Echinococcus granulosus smad 0.0009 0.0022 0.0024
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0032 0.0084
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0033
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0136 0.0153
Echinococcus granulosus Smad4 0.0009 0.0022 0.0024
Brugia malayi Smad1 0.0009 0.0022 0.0022
Brugia malayi Importin beta-1 subunit 0.003 0.0287 0.0298
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1782 1
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0136 0.0153
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0034 0.0035
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0404 0.0455
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Loa Loa (eye worm) hypothetical protein 0.0023 0.0204 0.0212
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0411 0.1097
Echinococcus multilocularis snurportin 1 0.0315 0.3948 0.3948
Echinococcus granulosus Chromo domain 0.0012 0.0059 0.0066
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0039 0.0405 0.0903
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0132 0.0295
Mycobacterium leprae Probable lipase LipE 0.0035 0.0357 0.2003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0049 0.0055
Schistosoma mansoni leucine aminopeptidase 0.002 0.017 0.0191
Mycobacterium ulcerans hypothetical protein 0.0035 0.0357 0.2003
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0357 0.0954
Loa Loa (eye worm) hypothetical protein 0.005 0.0553 0.0573
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0059 0.0059
Onchocerca volvulus 0.0011 0.0049 0.0028
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1782 0.6431
Schistosoma mansoni lamin 0.003 0.029 0.0326
Brugia malayi lysyl-tRNA synthetase 0.0028 0.027 0.028
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Entamoeba histolytica protein kinase, putative 0.0039 0.0404 0.108
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.1231 0.1276
Trypanosoma brucei sugar transporter, putative 0.0018 0.0136 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0157
Brugia malayi SET domain containing protein 0.0012 0.0059 0.0061
Schistosoma mansoni glucose transport protein 0.0126 0.1527 0.1717
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0035
Loa Loa (eye worm) aminopeptidase in chromosome V 0.002 0.017 0.0176
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0405 0.0597
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0022 0.0022
Echinococcus multilocularis geminin 0.0701 0.8891 0.8891
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0132 0.0137
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0216 0.0319
Plasmodium falciparum phd finger protein, putative 0.003 0.0292 0.043
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0327 0.0327
Echinococcus multilocularis importin subunit beta 1 0.003 0.0287 0.0287
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0039 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0051
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.008 0.066
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0272 0.0726
Brugia malayi chromobox protein homolog 3 0.004 0.0421 0.0437
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0718 0.4031
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0157
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0039 0.0044
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.1 0.1125
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.008 0.0215
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.3948 0.4093
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0411 0.0426
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1527 0.1527
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0224 0.0224
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0059 0.0066
Echinococcus granulosus General substrate transporter 0.0108 0.1299 0.1461
Loa Loa (eye worm) hypothetical protein 0.0041 0.0435 0.0451
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Echinococcus granulosus snurportin 1 0.0315 0.3948 0.444
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0049 0.0055
Loa Loa (eye worm) beta-lactamase 0.0035 0.0357 0.037
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0049 0.0051
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.1527 0.3408
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1153 0.1297
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.027 0.0399
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0049 0.0055
Schistosoma mansoni sugar transporter 0.0018 0.0136 0.0153
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0204 0.0212
Toxoplasma gondii exonuclease III APE 0.0018 0.0143 0.0319
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0183 0.019
Schistosoma mansoni chromobox protein 0.0012 0.0059 0.0066
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0022 0.0022
Onchocerca volvulus 0.0096 0.1142 0.1804
Brugia malayi jmjC domain containing protein 0.0026 0.0238 0.0247
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0238 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0435 0.1161
Loa Loa (eye worm) aminopeptidase in chromosome III 0.002 0.017 0.0176
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0238 0.0247
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0357 0.0954
Loa Loa (eye worm) hypothetical protein 0.0029 0.0283 0.0293
Loa Loa (eye worm) hypothetical protein 0.0124 0.1494 0.1549
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0136 0.0364
Schistosoma mansoni survival motor neuron protein 0.0096 0.1142 0.1284
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.1144 0.1286
Echinococcus multilocularis protein patched 0.0041 0.0435 0.0435
Echinococcus granulosus GPCR family 2 0.0033 0.0327 0.0368
Echinococcus granulosus solute carrier family 22 0.0018 0.0136 0.0153
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0226 0.0603
Plasmodium falciparum importin beta, putative 0.003 0.0287 0.0424
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0292 0.0302
Brugia malayi DKFZp564C0469 protein 0.001 0.0032 0.0033
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0136 0.0141
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0032 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0049 0.0049
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0059 0.0157
Echinococcus multilocularis muscleblind protein 1 0.0164 0.2017 0.2017
Brugia malayi hypothetical protein 0.0012 0.0059 0.0061
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0357 0.0954
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0143 0.0382
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0132 0.0132
Trichomonas vaginalis esterase, putative 0.0035 0.0357 0.0954
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.002 0.017 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0084
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1782 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3744 1
Schistosoma mansoni patched 1 0.0041 0.0435 0.0489
Leishmania major glucose transporter, lmgt2 0.0039 0.0411 0.0426
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0077 0.008
Brugia malayi MH1 domain containing protein 0.0009 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0129 0.0134
Brugia malayi Cam kinase protein 1 0.0039 0.0404 0.0419
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0287 0.0298
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0049 0.0055
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0158 0.1933 0.1933
Plasmodium falciparum mitogen-activated protein kinase 2 0.0204 0.2523 0.3724
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0216 0.0224
Leishmania major C-8 sterol isomerase-like protein 0.076 0.9646 1
Echinococcus granulosus geminin 0.0701 0.8891 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0132 0.0476
Loa Loa (eye worm) hypothetical protein 0.0194129 0.359325 0.359325
Schistosoma mansoni hypothetical protein 0.004 0.0416 0.0468
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0059 0.0157
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0327 0.0339
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0049 0.0055
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0059 0.0059
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0022 0.0024
Schistosoma mansoni topbp1 0.001 0.0032 0.0035
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0016 0.0108 0.0112
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0216 0.0482
Toxoplasma gondii leucyl aminopeptidase LAP 0.0102 0.1219 0.272
Brugia malayi MH2 domain containing protein 0.0129 0.1562 0.1619
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0143 0.0211
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Brugia malayi Sugar transporter family protein 0.0018 0.0136 0.0141
Brugia malayi RNA, U transporter 1 0.0084 0.0985 0.1021
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0157
Brugia malayi beta-lactamase family protein 0.0035 0.0357 0.037
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0049 0.0055
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0008 0.0011 0.0012
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0204 0.0545
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0033
Echinococcus granulosus leucyl aminopeptidase 0.002 0.017 0.0191
Echinococcus multilocularis expressed conserved protein 0.009 0.106 0.106
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0204 0.1145
Echinococcus multilocularis serotonin receptor 0.0128 0.1551 0.1551
Schistosoma mansoni protein kinase 0.0039 0.0404 0.0455
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0435 0.0435
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0059 0.0157
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0238 0.0532
Leishmania major GTP-binding protein, putative 0.0022 0.0187 0.0194
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0216 0.0778
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0132 0.0295
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0143 0.0382
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0718 0.0808
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0012 0.0059 0.0059
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0238 0.0352
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0238 0.0268
Onchocerca volvulus 0.0018 0.0136 0.017
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0238 0.0238
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.1527 0.1527
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0129 0.0726
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0718 0.0808
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0049 0.0055
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.0426
Brugia malayi ecdysteroid receptor 0.0011 0.0049 0.0051
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0049 0.0049
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0039 0.0405 0.0597
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0186 0.0274
Schistosoma mansoni glucose transport protein 0.0126 0.1527 0.1717
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0187 0.0418
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0049 0.0055
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0059 0.0131
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0404 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Giardia lamblia Hexose transporter 0.0018 0.0136 0.0364
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0132 0.0148
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0187 0.0277
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0032 0.007
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0204 0.1145
Giardia lamblia PHD finger protein 15 0.003 0.0292 0.0779
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0292 0.0292
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0136 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0049 0.0051
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0136 0.0141
Schistosoma mansoni hypothetical protein 0.0701 0.8891 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0204 0.2523 0.5632
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0718 0.0718
Echinococcus granulosus muscleblind protein 0.0164 0.2017 0.2269
Echinococcus multilocularis lysine specific demethylase 5A 0.0096 0.1144 0.1144
Toxoplasma gondii ABC1 family protein 0.0035 0.0357 0.0797
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0051
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.037
Onchocerca volvulus 0.0018 0.0136 0.017
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0357 0.1288
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0059 0.0061
Trypanosoma brucei glucose transporter 2A 0.0039 0.0411 0.0426
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0026 0.0238 0.0268
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0032 0.0033
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0394 0.1053
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0475 0.0492
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Brugia malayi CHD4 protein 0.0012 0.0059 0.0061
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0411 0.0426
Echinococcus multilocularis peregrin 0.003 0.0292 0.0292
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0823 0.0853
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0238 0.0268
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0049 0.0055
Echinococcus multilocularis nibrin 0.001 0.0032 0.0032
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.3744 1
Plasmodium vivax hypothetical protein, conserved 0.001 0.0034 0.005
Schistosoma mansoni hypothetical protein 0.0033 0.0327 0.0368
Brugia malayi topoisomerase 0.001 0.0032 0.0033
Onchocerca volvulus 0.0018 0.0136 0.017
Plasmodium vivax hexose transporter 0.0126 0.1527 0.2253
Echinococcus granulosus biogenic amine 5HT receptor 0.0128 0.1551 0.1744
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0357 0.1288
Brugia malayi ERG2 and Sigma1 receptor like protein 0.037806 1 0.5
Schistosoma mansoni glucose transporter 0.0018 0.0136 0.0153
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0102 0.1219 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0059 0.0157
Toxoplasma gondii sugar transporter ST2 0.0018 0.0136 0.0305
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0129 0.1062
Echinococcus granulosus leucine aminopeptidase protein 0.0102 0.1219 0.1371
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0292 0.0328
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0143 0.0382
Plasmodium vivax JmjC domain containing protein 0.0026 0.0238 0.0352
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0357 0.2003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0049 0.0051
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.1562 0.1619
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.3744 1
Loa Loa (eye worm) RecQ helicase 0.0025 0.0224 0.0232
Brugia malayi jmjC domain containing protein 0.0096 0.1144 0.1186
Mycobacterium ulcerans sugar transporter 0.0018 0.0136 0.0766
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0061
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0132 0.0137
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0357 0.2003
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1134 0.3029
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0049 0.0055
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0051
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0187 0.0194
Schistosoma mansoni biogenic amine (5HT) receptor 0.00909716 0 0.5
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0357 0.1288
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0216 0.0576
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3744 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0061
Schistosoma mansoni protein kinase 0.0039 0.0404 0.0455
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3744 1
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0435 0.0489
Mycobacterium tuberculosis Conserved protein 0.0035 0.0357 0.1288
Leishmania major glucose transporter, lmgt3 0.0039 0.0411 0.0426
Schistosoma mansoni biogenic amine (5HT) receptor 0.0128 0.1551 0.1744
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1134 0.1134
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0059 0.0066
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1527 0.1527
Schistosoma mansoni protein kinase 0.0039 0.0404 0.0455
Echinococcus multilocularis GPCR, family 2 0.0033 0.0327 0.0327
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0699 0.0724
Echinococcus multilocularis protein dispatched 1 0.0047 0.0509 0.0509
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0039 0.0404 0.0419
Entamoeba histolytica hypothetical protein 0.0024 0.0216 0.0576
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0157
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0059 0.0087
Schistosoma mansoni Smad4 0.0009 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.0164 0.2017 0.2091
Echinococcus granulosus solute carrier family 22 0.0018 0.0136 0.0153
Brugia malayi intermediate filament protein 0.003 0.029 0.03
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0032 0.0084
Trypanosoma cruzi C-8 sterol isomerase, putative 0.037806 1 0.5
Entamoeba histolytica hypothetical protein 0.001 0.0032 0.0084
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0204 0.0212
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0061
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0394 0.0443
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0136 0.0492
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0032 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0049 0.0051
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.001 0.0034 0.005
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0158 0.1933 0.2175
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.0426
Echinococcus granulosus bloom syndrome protein 0.0025 0.0224 0.0252
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0475 0.0492
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0136 0.0141
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0049 0.0055
Onchocerca volvulus 0.0012 0.0059 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0051
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0411 0.1097
Brugia malayi Muscleblind-like protein 0.0164 0.2017 0.2091
Schistosoma mansoni sugar transporter 0.0018 0.0136 0.0153
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0394 0.0443
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0475 0.0492
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0216 0.0224
Echinococcus granulosus solute carrier family 22 0.0018 0.0136 0.0153
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Schistosoma mansoni ran 0.0022 0.0187 0.0211
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.002 0.017 0.0191
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0292 0.0328
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0032 0.0084
Brugia malayi hypothetical protein 0.0018 0.0136 0.0141
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0032 0.0084
Onchocerca volvulus 0.0012 0.0059 0.0044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0049 0.0051
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0022 0.0022
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0132 0.0137
Plasmodium falciparum calcium-dependent protein kinase 1 0.0039 0.0405 0.0597
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0132 0.0132
Entamoeba histolytica protein kinase, putative 0.0039 0.0404 0.108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0059 0.0157
Brugia malayi beta-lactamase family protein 0.0035 0.0357 0.037
Leishmania major hypothetical protein, conserved 0.0026 0.0238 0.0247
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0143 0.0382
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0061
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0357 0.1288
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0143 0.0802
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.027 0.028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0204 0.0736
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0059 0.0157
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0049 0.0055
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0059 0.0131
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.037
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0102 0.1219 0.1263
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0026 0.0238 0.0238
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0059 0.0061
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0475 0.0492
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0187 0.0194
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0204 0.1145
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0421 0.0633
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0204 0.0736
Schistosoma mansoni chromobox protein 0.0012 0.0059 0.0066
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.027 0.028
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0357 0.1288
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0049 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0059 0.0157
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0216 0.1211
Echinococcus multilocularis survival motor neuron protein 1 0.0472 0.5954 0.5954
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1527 0.1527
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0136 0.0364
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Brugia malayi MH1 domain containing protein 0.0009 0.0022 0.0022
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0718 0.1604
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.049 0.0508
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0411 0.0426
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0357 0.037
Echinococcus granulosus chromobox protein 1 0.0071 0.0823 0.0926
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.0426
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.1562 0.1619
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.0426
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0102 0.1219 0.1263
Schistosoma mansoni hypothetical protein 0.004 0.0416 0.0468
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0187 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0049 0.0051
Brugia malayi cytosol aminopeptidase 0.002 0.017 0.0176
Plasmodium falciparum calcium-dependent protein kinase 5 0.0039 0.0405 0.0597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0049 0.0051
Plasmodium falciparum protein kinase 6 0.0536 0.6775 1
Brugia malayi steroid hormone receptor 0.0011 0.0049 0.0051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0117 0.0424
Onchocerca volvulus 0.0018 0.0136 0.017
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0718 0.0745
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0117 0.0424
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0441 0.0441
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.1231 0.1276
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.037
Trypanosoma brucei C-8 sterol isomerase, putative 0.076 0.9646 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0059 0.0157
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.027 0.0304
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0357 0.0954
Echinococcus multilocularis leucyl aminopeptidase 0.002 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Echinococcus granulosus peregrin 0.003 0.0292 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0421 0.1126
Echinococcus granulosus intermediate filament protein 0.003 0.029 0.0326
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0187 0.0194
Loa Loa (eye worm) hypothetical protein 0.003 0.0292 0.0302
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0411 0.0426
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.027 0.1515
Leishmania major hypothetical protein, conserved 0.0035 0.0357 0.037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0059 0.0157
Echinococcus granulosus biogenic amine 5HT receptor 0.00909716 0 0.5
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0136 0.0141
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0216 0.0779
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0059 0.0157
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1527 0.1717
Schistosoma mansoni hypothetical protein 0.0033 0.0327 0.0368
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0032 0.007
Echinococcus multilocularis solute carrier family 22 0.0018 0.0136 0.0136
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0059 0.0066
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Schistosoma mansoni importin beta-1 0.003 0.0287 0.0323
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0132 0.0132
Echinococcus multilocularis leucyl aminopeptidase 0.002 0.017 0.017
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Brugia malayi hypothetical protein 0.0018 0.0136 0.0141
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0216 0.121
Echinococcus multilocularis chromobox protein 2 0.0012 0.0059 0.0059
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0327 0.0368
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1527 0.1717
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0327 0.0368
Onchocerca volvulus 0.0018 0.0136 0.017
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0187 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0084
Brugia malayi hypothetical protein 0.001 0.0032 0.0033
Brugia malayi Heterochromatin protein 1 0.0071 0.0823 0.0853
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0204 0.0545
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0032 0.0177
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0238 0.0238
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1527 0.1717
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0059 0.0087
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0136 0.0492
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0374 0.042
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0204 0.0212
Loa Loa (eye worm) hypothetical protein 0.0038 0.0394 0.0409
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0238 0.0247
Onchocerca volvulus 0.0031 0.0311 0.0453
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0143 0.0382
Brugia malayi major facilitator superfamily protein 0.0018 0.0136 0.0141
Onchocerca volvulus 0.0018 0.0136 0.017
Brugia malayi PHD-finger family protein 0.003 0.0292 0.0302
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0129 0.0191
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Loa Loa (eye worm) hypothetical protein 0.0164 0.2017 0.2091
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0411 0.0426
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0049 0.0051
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.002 0.017 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.076 0.9646 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0204 0.1145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.049 0.0551
Onchocerca volvulus 0.0012 0.0059 0.0044
Brugia malayi MH2 domain containing protein 0.0009 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.003 0.029 0.03
Schistosoma mansoni glucose transport protein 0.0126 0.1527 0.1717
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0049 0.0049
Onchocerca volvulus 0.0018 0.0136 0.017
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0039 0.0404 0.0419
Onchocerca volvulus 0.0018 0.0136 0.017
Loa Loa (eye worm) hypothetical protein 0.0085 0.1 0.1037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3744 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0049 0.0051
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0411 0.0426
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0033
Leishmania major hypothetical protein, conserved 0.0018 0.0136 0.0141
Onchocerca volvulus 0.003 0.029 0.0419
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0718 0.4031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0059 0.0157
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0051
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0129 0.0191
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.049 0.049
Brugia malayi Bromodomain containing protein 0.003 0.0292 0.0302
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0238 0.0268
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0143 0.0143
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3744 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0039 0.004
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0039 0.0087
Schistosoma mansoni smad1 5 8 and 0.0009 0.0022 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Schistosoma mansoni jumonji domain containing protein 0.0138 0.1676 0.1885
Loa Loa (eye worm) hypothetical protein 0.0023 0.0204 0.0212
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.1142 0.1184
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0049 0.0055
Loa Loa (eye worm) hypothetical protein 0.0026 0.0238 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0049 0.0051
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Schistosoma mansoni smad1 5 8 and 0.0009 0.0022 0.0024
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0049 0.0055
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0216 0.0224
Entamoeba histolytica hypothetical protein 0.0012 0.0059 0.0157
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0049 0.0055
Echinococcus multilocularis serotonin receptor 0.00909716 0 0.5
Schistosoma mansoni hypothetical protein 0.001 0.0034 0.0038
Treponema pallidum DNA ligase (lig) 0.001 0.0032 0.0084
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0059 0.0157
Loa Loa (eye worm) hypothetical protein 0.0031 0.0303 0.0314
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0039 0.0404 0.0419
Echinococcus granulosus lamin 0.003 0.029 0.0326
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0143 0.0148
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0404 0.0455
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0404 0.0455
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0216 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0421 0.1126
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Toxoplasma gondii protein kinase, putative 0.0357 0.448 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0238 0.0247
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0411 0.0426
Loa Loa (eye worm) hypothetical protein 0.049 0.6188 0.6415
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0357 0.0402
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.049 0.0551
Echinococcus multilocularis Chromo domain 0.0012 0.0059 0.0059
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0204 0.1145
Brugia malayi ERG2 and Sigma1 receptor like protein 0.076 0.9646 1
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.027 0.0721
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0136 0.0136
Echinococcus granulosus survival motor neuron protein 1 0.0472 0.5954 0.6697
Mycobacterium ulcerans lipase LipD 0.0035 0.0357 0.2003
Brugia malayi MH2 domain containing protein 0.0009 0.0022 0.0022
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0475 0.0492
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0077 0.008
Trypanosoma brucei aminopeptidase, putative 0.002 0.017 0.0176
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0187 0.0187
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.0426
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0132 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1527 0.4078
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0084
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0034 0.0076
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0132 0.0132
Toxoplasma gondii sugar transporter ST3 0.0018 0.0136 0.0305
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0394 0.0409
Echinococcus granulosus lamin dm0 0.003 0.029 0.0326
Loa Loa (eye worm) Smad1 0.0009 0.0022 0.0022
Echinococcus granulosus Chromobox protein 3 0.0012 0.0059 0.0066
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0122 0.018
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0032 0.0033
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0224 0.0232
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0143 0.0516
Schistosoma mansoni chromobox protein 0.0071 0.0823 0.0926
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0216 0.1211
Onchocerca volvulus Alhambra homolog 0.003 0.0292 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0411 0.1097
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0049 0.0028
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0039 0.0405 0.0597
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0049 0.0049
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0238 0.0238
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0357 0.1288
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0718 0.0808
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0022 0.0024
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0238 0.0268
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0012 0.0059 0.0066
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0051
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0238 0.0268
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0238 0.0247
Toxoplasma gondii sugar transporter ST1 0.0018 0.0136 0.0305
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0394 0.2212
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0143 0.1174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.049 0.0551
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0032 0.0047
Trichomonas vaginalis chromobox protein, putative 0.0043 0.046 0.123
Onchocerca volvulus 0.003 0.029 0.0419
Plasmodium vivax calcium-dependent protein kinase, putative 0.0039 0.0405 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0143 0.0161
Echinococcus multilocularis solute carrier family 22 0.0018 0.0136 0.0136
Schistosoma mansoni hypothetical protein 0.0126 0.1527 0.1717
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0059 0.0061
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0475 0.106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.037
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.008 0.0451
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.1231 0.1276
Loa Loa (eye worm) helicase 0.0012 0.0059 0.0061
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0039 0.0087
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0411 0.1097
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0132 0.0132
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0136 0.0141
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0132 0.0137
Loa Loa (eye worm) hypothetical protein 0.0128 0.1551 0.1607
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0034 0.0035
Loa Loa (eye worm) sugar transporter 0.0018 0.0136 0.0141
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0039 0.0405 0.0903
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0216 0.0576
Echinococcus multilocularis smad 0.0009 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0049 0.0051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.049 0.0551
Echinococcus granulosus solute carrier family 22 0.0018 0.0136 0.0153
Trypanosoma brucei glucose transporter 1E 0.0039 0.0411 0.0426
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0077 0.008
Onchocerca volvulus 0.0035 0.0357 0.0529
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0032 0.0033
Entamoeba histolytica hypothetical protein 0.0028 0.027 0.0721
Echinococcus multilocularis chromobox protein 1 0.0071 0.0823 0.0823
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0238 0.0247
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0132 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0157
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0049 0.0049
Echinococcus multilocularis muscleblind protein 0.0164 0.2017 0.2017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.049 0.0551
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0136 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0032 0.0033
Brugia malayi CHE-14 protein 0.0041 0.0435 0.0451
Plasmodium vivax hypothetical protein, conserved 0.003 0.0292 0.043
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0435 0.0489
Schistosoma mansoni chromobox protein 0.0071 0.0823 0.0926
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0049 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0357 0.037
Leishmania major importin beta-1 subunit, putative 0.0024 0.0216 0.0224
Mycobacterium tuberculosis Conserved protein 0.0035 0.0357 0.1288
Echinococcus multilocularis serotonin receptor 0.0128 0.1551 0.1551
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3744 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.037806 1 0.5
Schistosoma mansoni hypothetical protein 0.0701 0.8891 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0327 0.0327
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0238 0.0268
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0049 0.0051
Schistosoma mansoni hypothetical protein 0.0033 0.0327 0.0368
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0216 0.1771
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0059 0.0157
Entamoeba histolytica hypothetical protein 0.0012 0.0059 0.0157
Schistosoma mansoni hypothetical protein 0.004 0.0416 0.0468
Brugia malayi nuclear hormone receptor 0.0011 0.0049 0.0051
Onchocerca volvulus 0.049 0.6188 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0034 0.0076
Echinococcus multilocularis lamin dm0 0.003 0.029 0.029
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0059 0.0066
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0077 0.0206
Onchocerca volvulus 0.0018 0.0136 0.017
Leishmania major glucose transporter, lmgt1 0.0039 0.0411 0.0426
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.027 0.2216
Trypanosoma cruzi hexose transporter 0.0039 0.0411 0.0426
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0132 0.0195
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0394 0.0409
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0216 0.0576
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0136 0.0136
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.029 0.03
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3744 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0039 0.0404 0.0419
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0143 0.0211
Brugia malayi jmjC domain containing protein 0.0026 0.0238 0.0247
Trichomonas vaginalis chromobox protein, putative 0.0043 0.046 0.123
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0204 0.1145
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.027 0.028
Brugia malayi nuclear receptor NHR-88 0.0011 0.0049 0.0051
Brugia malayi AF-10 protein 0.001 0.0034 0.0035
Loa Loa (eye worm) hypothetical protein 0.0071 0.0813 0.0843
Brugia malayi hypothetical protein 0.0472 0.5954 0.6173
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.027 0.1515
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0404 0.0404
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.029 0.03
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0102 0.1219 0.1263
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0039 0.004
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.002 0.017 0.0176
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0034 0.0038
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.002 0.017 0.0176
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.166 0.166
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0049 0.0051
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0292 0.0651
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0039 0.004
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0143 0.0148
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0357 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0136 0.0364
Brugia malayi hypothetical protein 0.049 0.6188 0.6415
Loa Loa (eye worm) hypothetical protein 0.0128 0.1551 0.1607
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.1144 0.1286
Onchocerca volvulus 0.0018 0.0136 0.017
Leishmania major protein kinase, putative 0.0039 0.0404 0.0419
Loa Loa (eye worm) hypothetical protein 0.0067 0.0771 0.0799
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0136 0.0364
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.027 0.0603
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0357 0.0954
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0136 0.0364
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0039 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0049 0.0051
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0374 0.0374
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0049 0.0049
Onchocerca volvulus 0.0018 0.0136 0.017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.049 0.0508
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.027 0.1515
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0059 0.0157
Plasmodium falciparum calcium-dependent protein kinase 2 0.0039 0.0405 0.0597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0049 0.0051
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.002 0.017 0.0176
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0102 0.1219 0.1799
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0084
Echinococcus granulosus replication factor c subunit 1 0.001 0.0032 0.0035
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0051
Schistosoma mansoni smad 0.0009 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.037806 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0357 0.2003
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0388 0.4886 0.5065
Giardia lamblia Sugar-proton symporter 0.0018 0.0136 0.0364
Schistosoma mansoni intermediate filament proteins 0.003 0.029 0.0326
Schistosoma mansoni hypothetical protein 0.0033 0.0327 0.0368
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0287 0.0298
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1134 0.1276
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0132 0.0195
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0136 0.0364
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0102 0.1219 0.1263
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0049 0.0051
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0475 0.0701
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0204 0.0212
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0357 0.0527
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0049 0.0051
Loa Loa (eye worm) hypothetical protein 0.0033 0.0327 0.0339
Plasmodium falciparum calcium-dependent protein kinase 4 0.0039 0.0405 0.0597
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0032 0.0177
Brugia malayi Protein cec-1. 0.0012 0.0059 0.0061
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.027 0.027
Echinococcus multilocularis General substrate transporter 0.0108 0.1299 0.1299
Loa Loa (eye worm) intermediate filament protein 0.003 0.029 0.03
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.002 0.017 0.0176
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.027 0.0304
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0136 0.0141
Echinococcus multilocularis musashi 0.003 0.029 0.029
Schistosoma mansoni ap endonuclease 0.0018 0.0143 0.0161
Brugia malayi Sugar transporter family protein 0.0018 0.0136 0.0141
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.002 0.017 0.0176
Echinococcus multilocularis leucine aminopeptidase protein 0.0102 0.1219 0.1219
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0049 0.0051
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0049 0.0049
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0059 0.0157
Echinococcus multilocularis leucyl aminopeptidase 0.002 0.017 0.017
Mycobacterium ulcerans leucyl aminopeptidase 0.0102 0.1219 0.6838
Plasmodium falciparum hexose transporter 0.0126 0.1527 0.2253
Schistosoma mansoni ap endonuclease 0.0018 0.0143 0.0161
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0357 0.0402
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0394 0.0443
Echinococcus granulosus importin subunit beta 1 0.003 0.0287 0.0323
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0049 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0404 0.0455
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.0426
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0033
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0032 0.0084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0204 0.0212
Echinococcus multilocularis solute carrier family 22 0.0018 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0028 0.027 0.028
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0238 0.0247
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0204 0.0212
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0143 0.0148
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0394 0.1053
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1134 0.1176
Loa Loa (eye worm) hypothetical protein 0.004 0.0421 0.0437
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Schistosoma mansoni hypothetical protein 0.004 0.0416 0.0468
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.166 0.1867
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0049 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0157
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0823 0.2199
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.1 0.1037
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0216 0.0482
Loa Loa (eye worm) hypothetical protein 0.0014 0.0086 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0404 0.108
Loa Loa (eye worm) hypothetical protein 0.0096 0.1134 0.1176
Brugia malayi beta-lactamase 0.0035 0.0357 0.037
Brugia malayi jmjC domain containing protein 0.0158 0.1933 0.2004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0117 0.0424
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.046 0.0696
Echinococcus granulosus chromobox protein 2 0.0012 0.0059 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0136 0.0364
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2771 1
Onchocerca volvulus 0.0035 0.0357 0.0529
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0411 0.1097
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0357 0.0402
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0039 0.0104
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0216 0.0778
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.027 0.0304
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0136 0.0305
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0136 0.0766
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0059 0.0087
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Trichomonas vaginalis ran, putative 0.0022 0.0187 0.0501
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.0426
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0022 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0204 0.0212
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0411 0.1097
Echinococcus granulosus expressed conserved protein 0.009 0.106 0.1192
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.1144 0.1186
Onchocerca volvulus 0.0085 0.1 0.1573
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0238 0.0532
Echinococcus multilocularis Smad4 0.0009 0.0022 0.0022
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0049 0.0055
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0136 0.0364
Mycobacterium tuberculosis Conserved protein 0.0035 0.0357 0.1288
Brugia malayi jmjC domain containing protein 0.0026 0.0238 0.0247
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.027 0.0399
Chlamydia trachomatis DNA ligase 0.001 0.0032 0.0259
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0102 0.1219 0.6838
Loa Loa (eye worm) hypothetical protein 0.0014 0.0093 0.0096
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0059 0.0087
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.1 0.1125
Loa Loa (eye worm) hypothetical protein 0.0017 0.0129 0.0134
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0187 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0059 0.0157
Schistosoma mansoni hypothetical protein 0.0071 0.0813 0.0914
Schistosoma mansoni hypothetical protein 0.0096 0.1142 0.1284
Schistosoma mansoni hypothetical protein 0.003 0.0292 0.0328
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0136 0.0141
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0032 0.0032
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.027 0.0721
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0034 0.0035
Plasmodium falciparum M17 leucyl aminopeptidase 0.0102 0.1219 0.1799
Loa Loa (eye worm) hypothetical protein 0.0018 0.0136 0.0141
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0049 0.0055
Plasmodium falciparum calcium-dependent protein kinase 3 0.0039 0.0405 0.0597
Echinococcus multilocularis chromobox protein 1 0.0071 0.0823 0.0823
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0823 0.2199
Loa Loa (eye worm) hypothetical protein 0.0026 0.0238 0.0247
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0224 0.0598
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0441 0.0496
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0032 0.0035
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0113 0.0117
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0102 0.1219 0.4397
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0357 0.037
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0059 0.0131
Schistosoma mansoni topbp1 0.001 0.0032 0.0035
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0158 0.0177
Onchocerca volvulus 0.0018 0.0136 0.017
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0093 0.0104
Onchocerca volvulus 0.0018 0.0136 0.017
Schistosoma mansoni smad1 5 8 and 0.0009 0.0022 0.0024
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0132 0.0137
Brugia malayi Sugar transporter family protein 0.0126 0.1527 0.1583
Trypanosoma brucei glucose transporter, putative 0.0039 0.0411 0.0426
Schistosoma mansoni ran 0.0022 0.0187 0.0211
Loa Loa (eye worm) hypothetical protein 0.0017 0.0129 0.0134
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0204 0.2523 0.3724
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0032 0.0259
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0357 0.037
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0059 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0272 0.0726
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.002 0.017 0.0176
Brugia malayi jmjC domain containing protein 0.0026 0.0238 0.0247
Schistosoma mansoni sugar transporter 0.0018 0.0136 0.0153
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0059 0.0157
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0033
Echinococcus granulosus phd:f box containing protein 0.0026 0.0238 0.0268
Onchocerca volvulus 0.0023 0.0204 0.028
Onchocerca volvulus Putative transporter 0.0018 0.0136 0.017
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0292 0.0651
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0136 0.0766
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0187 0.0501

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 184 nM MMV: Inhibition of Plasmodium falciparum K1 (EC50). ChEMBL. No reference
EC50 (functional) = 439 nM MMV: Inhibition of Plasmodium falciparum 3D7 (EC50). ChEMBL. No reference
EC50 (functional) = 0.28 uM Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) 0.2843 uM ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) = 1.49 uM Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) 1.4909 uM ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
Growth Inhibition (functional) = 25.403 % MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. ChEMBL. No reference
IC50 (functional) = 617.2 nM MMV: IC50 determined against P. falciparum Dd2-luc strain using a Malaria Sybr Green I Fluorescence assay. Starting conditions were 1% trophozoite synchronised parasites at 2% haematocrit. Fluorescence detection completed after 48hr incubation at 37 degrees C under 1% O2, 3% CO2 and balance N2. ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 12000 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 1 uM MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) > 2.5 uM MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. ChEMBL. No reference
IC50 (functional) = 7.00163698196411 uM MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). ChEMBL. No reference
IC50 (functional) = 11.0160760879517 uM MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). ChEMBL. No reference
IC50 (functional) > 30 uM MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. ChEMBL. No reference
IC50 (functional) > 30 uM MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. ChEMBL. No reference
IC50 > 32 uM MMV: Cytotoxicity against human fibroblasts (MRC-5) cells. ChEMBL. No reference
IC50 (functional) > 32 uM MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). ChEMBL. No reference
Inhibition (functional) = -64.93463416705171 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = -64.9346341670517 % MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. ChEMBL. No reference
Inhibition (functional) = -18.0957348536616 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 5.13984582002246 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 5.139845820022462 % MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 16.1 % MMV: Screen against Mtb, single point, replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 18.864299489017 % MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. ChEMBL. No reference
Inhibition (functional) = 20.5 % MMV: Screen against Mtb, single point, non replicating, at 25uM ChEMBL. No reference
Inhibition (functional) = 33 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Inhibition (functional) = 97 % MMV: Inhibition of Plasmodium falciparum 3D7 at 5uM compound concentration. ChEMBL. No reference
Inhibition (functional) = 99 % MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). ChEMBL. No reference
Percent growth inhibition (functional) = 94.3 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye Saint Jude. 20485428
Percent growth inhibition (functional) = 95.7 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye Saint Jude. 20485428
Ratio (functional) = 0.836065573770492 MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. ChEMBL. No reference
Relative Growth (functional) = -0.0581 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing ethanol and glycerol as carbon sources (Yeast Nitrogen Base, Ethanol, Glycerol; YNBEG). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 180 OD readings, corresponding to roughly 45 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = -0.0457 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in rich media containing dextrose as a carbon source (Yeast Extract, Peptone, Dextrose; YPD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Relative Growth (functional) = -0.0363 MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 0 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference
Toxicity (functional) = 2 MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense
Plasmodium falciparum ChEMBL23 20485428

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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