Detailed information for compound 77165

Basic information

Technical information
  • TDR Targets ID: 77165
  • Name: methyl N'-(2,4,6-trimethylphenyl)sulfonylcarb amimidate
  • MW: 256.321 | Formula: C11H16N2O3S
  • H donors: 1 H acceptors: 2 LogP: 2.26 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=N)NS(=O)(=O)c1c(C)cc(cc1C)C
  • InChi: 1S/C11H16N2O3S/c1-7-5-8(2)10(9(3)6-7)17(14,15)13-11(12)16-4/h5-6H,1-4H3,(H2,12,13)
  • InChiKey: GDJPLZYPNHEBBO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-methyl-3-(2,4,6-trimethylphenyl)sulfonyl-isourea
  • N'-(2,4,6-trimethylphenyl)sulfonylcarbamimidic acid methyl ester
  • 3-mesitylsulfonyl-2-methyl-isourea
  • 1-methoxy-N'-(2,4,6-trimethylphenyl)sulfonylmethanimidamide
  • 1-methoxy-N'-(2,4,6-trimethylphenyl)sulfonyl-formamidine
  • 1-methoxy-N'-(2,4,6-trimethylphenyl)sulfonylformamidine
  • 1-methoxy-N'-(2,4,6-trimethylphenyl)sulfonyl-methanimidamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protease, serine, 3 Starlite/ChEMBL References
Homo sapiens protease, serine, 2 (trypsin 2) References
Homo sapiens protease, serine, 1 (trypsin 1) References
Homo sapiens coagulation factor II (thrombin) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Brugia malayi Trypsin family protein Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma japonicum ko:K09639 transmembrane protease, serine 8, putative Get druggable targets OG5_126639 All targets in OG5_126639
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) Get druggable targets OG5_126639 All targets in OG5_126639
Onchocerca volvulus Get druggable targets OG5_126639 All targets in OG5_126639
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126639 All targets in OG5_126639
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni cercarial elastase (S01 family) protease, serine, 3 261 aa 234 aa 25.2 %
Schistosoma mansoni cercarial elastase (S01 family) protease, serine, 2 (trypsin 2) 247 aa 240 aa 25.8 %
Brugia malayi Trypsin family protein protease, serine, 1 (trypsin 1) 247 aa 287 aa 21.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii subtilisin SUB10 0.0369 0.0314 1
Brugia malayi Will die slowly protein 0.0069 0.0039 0.0039
Mycobacterium tuberculosis Probable thioesterase TesA 0.0074 0.0043 0.1366
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0045 0.0016 0.0021
Schistosoma mansoni glutamate receptor NMDA 0.0083 0.0051 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0317 0.0267 0.0343
Mycobacterium ulcerans polyketide synthase 0.0086 0.0054 0.1706
Echinococcus multilocularis 0.0101 0.0068 0.009
Loa Loa (eye worm) hypothetical protein 0.0591 0.0518 0.0517
Plasmodium falciparum plasmepsin IV 0.0035 0.0007 0.0138
Onchocerca volvulus 0.0444 0.0383 0.8159
Onchocerca volvulus 0.0035 0.0007 0.0127
Onchocerca volvulus 0.0406 0.0348 0.7418
Brugia malayi hypothetical protein 0.0317 0.0267 0.0267
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0066 0.0084
Loa Loa (eye worm) trypsin family protein 0.0038 0.001 0.0008
Echinococcus multilocularis MAM 0.0067 0.0037 0.0048
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0099 0.0066 0.189
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0066 0.0134
Toxoplasma gondii aspartyl protease ASP3 0.0035 0.0007 0.0149
Echinococcus granulosus lysine specific histone demethylase 1A 0.0101 0.0068 0.0086
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1669 0.151 0.3199
Echinococcus granulosus integrin alpha 3 0.1637 0.148 0.1911
Echinococcus multilocularis protoporphyrinogen oxidase 0.0101 0.0068 0.009
Brugia malayi Protein kinase domain containing protein 0.0043 0.0015 0.0015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2038 0.1849 0.3919
Plasmodium vivax subtilisin-like serine protease, putative 0.0369 0.0314 0.9295
Onchocerca volvulus 0.0067 0.0037 0.0764
Schistosoma mansoni chromatin regulatory protein sir2 0.067 0.0591 0.0763
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0201 0.0159 0.0159
Loa Loa (eye worm) acyl carrier protein 0.0041 0.0012 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2038 0.1849 0.3919
Chlamydia trachomatis protoporphyrinogen oxidase 0.0101 0.0068 0.4098
Echinococcus granulosus adam 0.0557 0.0487 0.0628
Loa Loa (eye worm) subtilase 0.0369 0.0314 0.0313
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0444 0.0383 0.0494
Loa Loa (eye worm) hypothetical protein 0.0636 0.0559 0.0558
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0042 0.0013 0.0016
Plasmodium falciparum plasmepsin I 0.0035 0.0007 0.0138
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0083 0.0051 0.0067
Brugia malayi Protein kinase domain containing protein 0.005 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0038 0.001 0.0008
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0007 0.0008
Echinococcus multilocularis transmembrane protease serine 3 0.0038 0.001 0.0011
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0101 0.0068 0.1939
Brugia malayi Uncoordinated protein 44 0.0029 0.0001 0.0001
Schistosoma mansoni dock 0.0043 0.0015 0.0018
Leishmania major subtilisin-like serine peptidase 0.0369 0.0314 0.5291
Toxoplasma gondii histone lysine-specific demethylase 0.0101 0.0068 0.2087
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0101 0.0068 0.0086
Loa Loa (eye worm) hypothetical protein 0.0538 0.0469 0.0468
Echinococcus granulosus Mastin 0.0038 0.001 0.0011
Schistosoma mansoni chromatin regulatory protein sir2 0.067 0.0591 0.0763
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0085 0.0053 0.1683
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0201 0.0159 0.5032
Toxoplasma gondii type I fatty acid synthase, putative 0.0091 0.0059 0.1802
Schistosoma mansoni discoidin domain receptor 0.0043 0.0015 0.0018
Echinococcus multilocularis integrin alpha 3 0.1637 0.148 0.2006
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0067 0.0037 0.0046
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0099 0.0066 0.0833
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0044 0.0015 0.0018
Loa Loa (eye worm) endoprotease bli-4 0.8443 0.774 0.7739
Loa Loa (eye worm) hypothetical protein 0.024 0.0195 0.0194
Mycobacterium ulcerans transcriptional regulator NrdR 0.0031 0.0004 0.0122
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0085 0.0053 0.1683
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0066 0.0134
Leishmania major sir2-family protein-like protein 0.0099 0.0066 0.1076
Echinococcus granulosus glycoprotein Antigen 5 0.0038 0.001 0.0011
Echinococcus granulosus membrane bound transcription factor site 1 0.0369 0.0314 0.0404
Schistosoma mansoni serine/threonine protein kinase 0.0243 0.0198 0.0255
Toxoplasma gondii PA14 domain-containing protein 0.0043 0.0015 0.0393
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0036 0.0008 0.0252
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0086 0.0054 0.1706
Brugia malayi Glutamate receptor 1 precursor 0.0066 0.0035 0.0035
Schistosoma mansoni tyrosine kinase 0.0463 0.0401 0.0516
Schistosoma mansoni hypothetical protein 0.006 0.003 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0091 0.0059 0.1854
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0008
Schistosoma mansoni integrin beta subunit 0.6371 0.5835 0.7538
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0007 0.0138
Brugia malayi Reprolysin 0.0142 0.0106 0.0106
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0243 0.0198 0.0267
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.001 0.0011
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0063 0.0033 0.0041
Brugia malayi hypothetical protein 0.0035 0.0007 0.0007
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0086 0.0054 0.1692
Trichomonas vaginalis conserved hypothetical protein 0.1669 0.151 0.3199
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0052 0.0023 0.0079
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0201 0.0159 0.2463
Plasmodium vivax aspartyl protease, putative 0.0035 0.0007 0.0138
Echinococcus granulosus Furin 1 0.2038 0.1849 0.2388
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0243 0.0198 0.0197
Loa Loa (eye worm) hypothetical protein 0.024 0.0195 0.0194
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0043 0.0015 0.0454
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0125 0.009 0.0088
Onchocerca volvulus 0.0538 0.0469 1
Echinococcus granulosus enteropeptidase 0.0038 0.001 0.0011
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0086 0.0054 0.1706
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0044 0.0015 0.0019
Echinococcus granulosus fibrillin 1 0.0241 0.0197 0.0253
Loa Loa (eye worm) hypothetical protein 0.0101 0.0068 0.0066
Schistosoma mansoni hypothetical protein 0.0045 0.0016 0.002
Toxoplasma gondii subtilisin SUB2 0.0369 0.0314 1
Brugia malayi Kelch motif family protein 0.1699 0.1538 0.1538
Schistosoma mansoni hypothetical protein 0.006 0.003 0.0038
Mycobacterium ulcerans NAD-dependent deacetylase 0.0099 0.0066 0.2097
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0099 0.0066 0.0833
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0369 0.0314 1
Giardia lamblia Tenascin-X 0.024 0.0195 0.0643
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.001 0.0011
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.001 0.0011
Brugia malayi Glutamate receptor 2 precursor 0.0066 0.0035 0.0035
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.006 0.003 0.0038
Loa Loa (eye worm) hypothetical protein 0.0038 0.001 0.0008
Brugia malayi transcriptional regulator, Sir2 family protein 0.0099 0.0066 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0129 0.0094 0.2991
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5154 0.4715 0.6091
Brugia malayi hypothetical protein 0.1674 0.1514 0.1514
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.067 0.0591 0.125
Loa Loa (eye worm) transcriptional regulator 0.0099 0.0066 0.0065
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0038 0.001 0.0011
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0015 0.0365
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0043 0.0015 0.0018
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.001 0.0011
Mycobacterium ulcerans polyketide synthase Pks9 0.0056 0.0026 0.0827
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0035 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0142 0.0105 0.0104
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0369 0.0314 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0066 0.0134
Loa Loa (eye worm) hypothetical protein 0.0035 0.0007 0.0006
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0043 0.0015 0.0026
Brugia malayi hypothetical protein 0.0101 0.0068 0.0068
Echinococcus granulosus protein arginine methyltransferase 0.003 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.005 0.0021 0.0025
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.001 0.0011
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0038 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0007 0.0006
Brugia malayi endoprotease bli-4 precursor 0.8443 0.774 0.774
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0201 0.0159 0.0204
Onchocerca volvulus 0.0069 0.0039 0.0801
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0369 0.0314 0.0313
Mycobacterium ulcerans fatty acid synthase Fas 0.0028 0.0001 0.0017
Loa Loa (eye worm) metalloprotease 0.0067 0.0037 0.0035
Schistosoma mansoni tumor necrosis factor receptor related 0.0044 0.0015 0.0018
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0015 0.0393
Loa Loa (eye worm) hypothetical protein 0.1674 0.1514 0.1513
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Onchocerca volvulus 0.0043 0.0015 0.0289
Plasmodium falciparum protoporphyrinogen oxidase 0.0101 0.0068 0.1939
Plasmodium vivax subtilisin-like protease 1 0.0369 0.0314 0.9295
Loa Loa (eye worm) hypothetical protein 0.0047 0.0018 0.0017
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0015 0.0018
Loa Loa (eye worm) proprotein convertase 2 0.2038 0.1849 0.1848
Brugia malayi angiogenesis inhibito 0.0142 0.0105 0.0105
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.067 0.0591 0.0763
Echinococcus multilocularis Furin 1 0.2038 0.1849 0.2507
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0008
Mycobacterium leprae Probable polyketide synthase Pks1 0.0091 0.0059 0.1854
Giardia lamblia Tenascin precursor 0.024 0.0195 0.0643
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Loa Loa (eye worm) hypothetical protein 0.3289 0.3 0.2999
Loa Loa (eye worm) hypothetical protein 0.0038 0.001 0.0008
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0015 0.0393
Toxoplasma gondii subtilisin SUB12 0.0369 0.0314 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0051 0.0049
Schistosoma mansoni glutamate receptor AMPA 0.0066 0.0035 0.0044
Brugia malayi Trypsin family protein 0.0038 0.001 0.001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.006 0.003 0.003
Echinococcus granulosus glutamate NMDA receptor subunit 0.0311 0.0261 0.0336
Brugia malayi Kringle domain containing protein 0.005 0.0021 0.0021
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0086 0.0054 0.1719
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0068 0.215
Toxoplasma gondii SWIRM domain-containing protein 0.0042 0.0013 0.0351
Plasmodium falciparum plasmepsin VI 0.0035 0.0007 0.0138
Mycobacterium leprae Possible secreted protease 0.0369 0.0314 1
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.006 0.003 0.0038
Echinococcus multilocularis chromatin regulatory protein sir2 0.067 0.0591 0.0801
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5154 0.4715 1
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0169 0.013 0.5
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0369 0.0314 0.0314
Onchocerca volvulus Fatty acid synthase homolog 0.016 0.0122 0.2579
Loa Loa (eye worm) hypothetical protein 0.1117 0.1002 0.1001
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0101 0.0068 0.1939
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Loa Loa (eye worm) hypothetical protein 0.0496 0.0431 0.043
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0143 0.0106 0.0142
Onchocerca volvulus 0.0038 0.001 0.0179
Plasmodium falciparum cysteine repeat modular protein 1 0.005 0.0021 0.0545
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0044 0.0015 0.0018
Giardia lamblia Tenascin-like 0.024 0.0195 0.0643
Schistosoma mansoni glutamate receptor NMDA 0.0311 0.0261 0.0336
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0099 0.0066 0.189
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0038 0.001 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0035 0.0007 0.0149
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0201 0.0159 0.2662
Giardia lamblia High cysteine protein 0.024 0.0195 0.0643
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0101 0.0068 0.2137
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0038 0.001 0.0011
Brugia malayi hypothetical protein 0.0038 0.001 0.001
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0074 0.0043 0.1351
Trypanosoma cruzi UDP-galactopyranose mutase 0.0101 0.0068 0.0863
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0083 0.0051 0.0067
Echinococcus granulosus tissue type plasminogen activator 0.005 0.0021 0.0025
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.001 0.0011
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0101 0.0068 0.215
Schistosoma mansoni hypothetical protein 0.0067 0.0037 0.0046
Loa Loa (eye worm) TK/EGFR protein kinase 0.0463 0.0401 0.0399
Trichomonas vaginalis conserved hypothetical protein 0.0369 0.0314 0.0661
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0045 0.0016 0.002
Plasmodium falciparum subtilisin-like protease 1 0.0369 0.0314 0.9295
Plasmodium falciparum subtilisin-like protease 3 0.0369 0.0314 0.9295
Entamoeba histolytica hypothetical protein, conserved 0.0099 0.0066 0.0907
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0143 0.0106 0.0136
Brugia malayi EGF-like domain containing protein 0.024 0.0195 0.0195
Giardia lamblia Hypothetical protein 0.067 0.0591 0.2045
Brugia malayi metalloprotease 0.0067 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.1669 0.151 0.3199
Echinococcus granulosus glutamate receptor 2 0.0037 0.0009 0.0011
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0099 0.0066 0.1076
Brugia malayi Integrin alpha pat-2 precursor 0.2202 0.2 0.2
Plasmodium falciparum plasmepsin II 0.0035 0.0007 0.0138
Echinococcus granulosus nmda type glutamate receptor 0.013 0.0094 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0021 0.0047
Loa Loa (eye worm) TK/ALK protein kinase 0.0067 0.0037 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.1669 0.151 0.3199
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0369 0.0314 0.0314
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.024 0.0195 0.0409
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0008
Brugia malayi Pepsin A precursor 0.0035 0.0007 0.0007
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0169 0.013 0.4152
Trichomonas vaginalis conserved hypothetical protein 0.1669 0.151 0.3199
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0043 0.0015 0.0018
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0045 0.0016 0.002
Onchocerca volvulus 0.0134 0.0098 0.2069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0061 0.0031 0.0981
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0035 0.0007 0.0149
Brugia malayi Protein kinase domain containing protein 0.003 0.0002 0.0002
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0099 0.0066 0.0907
Trypanosoma brucei subtilisin peptidase 0.0369 0.0314 0.5163
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0068 0.1939
Brugia malayi Protein kinase domain containing protein 0.0067 0.0037 0.0037
Entamoeba histolytica hypothetical protein 0.0047 0.0018 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0039 0.0011 0.0012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2038 0.1849 0.3919
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0201 0.0159 0.4677
Giardia lamblia Sirtuin type 2 0.0099 0.0066 0.0185
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0201 0.0159 1
Giardia lamblia Furin precursor putative serine protease 0.1669 0.151 0.5294
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Schistosoma mansoni chromatin regulatory protein sir2 0.067 0.0591 0.0763
Plasmodium vivax plasmepsin V, putative 0.0395 0.0338 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0068 0.0038 0.1199
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0099 0.0066 0.0084
Toxoplasma gondii hypothetical protein 0.024 0.0195 0.6188
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2038 0.1849 0.2388
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0013 0.0023
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.067 0.0591 1
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0066 0.189
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.067 0.0591 1
Brugia malayi NAD-dependent deacetylase SIRT1 0.0099 0.0066 0.0066
Giardia lamblia High cysteine membrane protein Group 2 0.3116 0.284 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0496 0.0431 0.0583
Schistosoma mansoni hypothetical protein 0.0043 0.0015 0.0018
Plasmodium falciparum plasmepsin IX 0.0035 0.0007 0.0138
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0035 0.0007 0.0008
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.001 0.0011
Echinococcus multilocularis integrin alpha ps 0.052 0.0453 0.0613
Mycobacterium ulcerans polyketide synthase 0.0091 0.0059 0.1868
Brugia malayi hypothetical protein 0.0067 0.0037 0.0037
Leishmania major UDP-galactopyranose mutase 0.0101 0.0068 0.1104
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0067 0.0037 0.0046
Plasmodium falciparum plasmepsin V 0.0395 0.0338 1
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0039 0.0011 0.0009
Echinococcus multilocularis integrin alpha ps 0.1156 0.1038 0.1406
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2038 0.1849 0.3919
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0008
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.001 0.0011
Plasmodium vivax aspartyl protease, putative 0.0035 0.0007 0.0138
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0201 0.0159 0.0214
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0027 0.0000063584 0.0002
Loa Loa (eye worm) hypothetical protein 0.0047 0.0018 0.0016
Echinococcus multilocularis glutamate receptor 2 0.0037 0.0009 0.0011
Echinococcus multilocularis integrin beta 2 0.8045 0.7374 1
Trichomonas vaginalis conserved hypothetical protein 0.1669 0.151 0.3199
Echinococcus multilocularis tissue type plasminogen activator 0.005 0.0021 0.0027
Loa Loa (eye worm) sirtuin 4 0.0099 0.0066 0.0065
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.001 0.0011
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0066 0.0134
Brugia malayi Disintegrin family protein 0.0101 0.0067 0.0067
Onchocerca volvulus 0.0369 0.0314 0.6684
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1669 0.151 0.3199
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0394 0.0338 0.5575
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0099 0.0066 0.0907
Schistosoma mansoni amine oxidase 0.0101 0.0068 0.0086
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0101 0.0067 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.001 0.0011
Brugia malayi ADAM-TS Spacer 1 family protein 0.0142 0.0105 0.0105
Toxoplasma gondii subtilisin SUB8 0.0369 0.0314 1
Plasmodium vivax plasmepsin IV, putative 0.0035 0.0007 0.0138
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0201 0.0159 0.0204
Loa Loa (eye worm) hypothetical protein 0.0075 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.005 0.0021 0.002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0756 0.067 0.0864
Giardia lamblia Tenascin-37 0.024 0.0195 0.0643
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0369 0.0314 1
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0028 0.0001 0.0017
Plasmodium vivax LCCL domain-containing protein 0.0043 0.0015 0.0365
Echinococcus multilocularis NMDA receptor 0.0045 0.0016 0.0021
Mycobacterium ulcerans thioesterase TesA 0.0074 0.0043 0.1366
Toxoplasma gondii type I fatty acid synthase, putative 0.0063 0.0033 0.0977
Trichomonas vaginalis conserved hypothetical protein 0.0369 0.0314 0.0661
Echinococcus multilocularis protein will die slowly 0.0069 0.0039 0.0051
Loa Loa (eye worm) hypothetical protein 0.0067 0.0037 0.0035
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0083 0.0051 0.0064
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0043 0.0015 0.0026
Trypanosoma brucei Silent information regulator 2 related protein 1 0.067 0.0591 1
Trichomonas vaginalis conserved hypothetical protein 0.0369 0.0314 0.0661
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0201 0.0159 1
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0031 0.0004 0.0122
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.067 0.0591 0.125
Brugia malayi hypothetical protein 0.0047 0.0018 0.0018
Onchocerca volvulus 0.024 0.0195 0.4147
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0045 0.0016 0.0021
Loa Loa (eye worm) hypothetical protein 0.0146 0.0109 0.0108
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1699 0.1538 0.1537
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Loa Loa (eye worm) hypothetical protein 0.0143 0.0106 0.0105
Brugia malayi Death domain containing protein 0.0029 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0099 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.8443 0.774 0.7739
Echinococcus granulosus integrin beta 2 0.8045 0.7374 0.9528
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1669 0.151 0.3199
Trichomonas vaginalis conserved hypothetical protein 0.1669 0.151 0.3199
Trichomonas vaginalis conserved hypothetical protein 0.1669 0.151 0.3199
Loa Loa (eye worm) hypothetical protein 0.0067 0.0037 0.0036
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0243 0.0198 0.0254
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0066 0.0084
Echinococcus granulosus integrin alpha ps 0.1156 0.1038 0.134
Loa Loa (eye worm) hypothetical protein 0.006 0.003 0.0029
Brugia malayi Furin-like cysteine rich region family protein 0.0463 0.0401 0.0401
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0008
Onchocerca volvulus 0.0038 0.001 0.0179
Plasmodium falciparum plasmepsin VII 0.0035 0.0007 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0007 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0056 0.0026 0.0811
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0101 0.0068 0.2087
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0038 0.001 0.0011
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0756 0.067 0.0907
Giardia lamblia Neurogenic locus Notch protein precursor 0.024 0.0195 0.0643
Schistosoma mansoni glutamate receptor kainate 0.0066 0.0035 0.0044
Plasmodium falciparum subtilisin-like protease 2 0.0369 0.0314 0.9295
Plasmodium falciparum plasmepsin X 0.0035 0.0007 0.0138
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0101 0.0068 0.1939
Loa Loa (eye worm) hypothetical protein 0.024 0.0195 0.0194
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Schistosoma mansoni hypothetical protein 0.0067 0.0037 0.0046
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0086 0.0054 0.0054
Echinococcus granulosus protein arginine N methyltransferase 8 0.003 0.0003 0.0002
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0369 0.0314 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.001 0.0008
Trichomonas vaginalis hypothetical protein 0.1669 0.151 0.3199
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0091 0.0059 0.1868
Onchocerca volvulus 0.0038 0.001 0.0179
Trypanosoma cruzi subtilisin peptidase 0.0369 0.0314 0.5163
Plasmodium vivax subtilisin-like protease 2, putative 0.0369 0.0314 0.9295
Toxoplasma gondii aspartyl protease ASP5 0.0359 0.0306 0.9723
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0083 0.0051 0.0067
Trichomonas vaginalis WD repeat domain, putative 0.0069 0.0039 0.0077
Brugia malayi Calcium binding EGF domain containing protein 0.0039 0.0011 0.0011
Mycobacterium ulcerans thioesterase 0.0074 0.0043 0.1366
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.001 0.0011
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0369 0.0314 0.0424
Brugia malayi ADAMTS-like protease 0.0142 0.0105 0.0105
Brugia malayi Trypsin family protein 0.0038 0.001 0.001
Brugia malayi EGF-like domain containing protein 0.024 0.0195 0.0195
Brugia malayi hypothetical protein 0.0035 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0007 0.0006
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0099 0.0066 0.0084
Schistosoma mansoni integrin alpha-ps 0.0636 0.0559 0.0721
Brugia malayi SWIRM domain containing protein 0.0042 0.0013 0.0013
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0015 0.0393
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0369 0.0314 1
Mycobacterium ulcerans oxidoreductase 0.0101 0.0068 0.215
Echinococcus multilocularis protein arginine N methyltransferase 8 0.003 0.0003 0.0002
Giardia lamblia hypothetical protein 0.024 0.0195 0.0643
Brugia malayi SWIRM domain containing protein 0.0538 0.0469 0.0469
Onchocerca volvulus 0.0035 0.0007 0.0127
Toxoplasma gondii subtilisin SUB5 0.0369 0.0314 1
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5154 0.4715 0.6393
Echinococcus granulosus transmembrane protease serine 3 0.0038 0.001 0.0011
Schistosoma mansoni amine oxidase 0.0101 0.0068 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0231 0.0187 0.024
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0047 0.0018 0.008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0001 0.0001
Plasmodium vivax aspartyl protease, putative 0.0035 0.0007 0.0138
Echinococcus granulosus chromatin regulatory protein sir2 0.067 0.0591 0.0763
Mycobacterium ulcerans polyketide synthase Pks13 0.0129 0.0094 0.2991
Loa Loa (eye worm) transcriptional regulator 0.0099 0.0066 0.0065
Echinococcus multilocularis glutamate receptor 2 0.0066 0.0035 0.0046
Loa Loa (eye worm) angiogenesis inhibito 0.0067 0.0037 0.0035
Toxoplasma gondii aspartyl protease ASP1 0.0035 0.0007 0.0149
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Echinococcus granulosus fibrillin 2 0.024 0.0195 0.0251
Brugia malayi EGF-like domain containing protein 0.024 0.0195 0.0195
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0099 0.0066 0.0088
Mycobacterium tuberculosis Possible oxidoreductase 0.0101 0.0068 0.215
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0369 0.0314 0.5163
Schistosoma mansoni hypothetical protein 0.0069 0.0039 0.0048
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0038 0.001 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Onchocerca volvulus 0.0067 0.0037 0.0764
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0066 0.0134
Brugia malayi Trypsin family protein 0.0038 0.001 0.001
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0201 0.0159 0.0158
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0099 0.0066 0.0088
Schistosoma mansoni protein kinase 0.0143 0.0106 0.0136
Schistosoma mansoni ATP-binding cassette transporter 0.0067 0.0036 0.0046
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0201 0.0159 0.2463
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0243 0.0198 0.0254
Schistosoma mansoni SWI/SNF complex-related 0.0042 0.0013 0.0016
Schistosoma mansoni integrin alpha 0.2202 0.2 0.2583
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0101 0.0068 0.215
Echinococcus multilocularis glutamate receptor 2 0.0083 0.0051 0.0067
Brugia malayi EGF-like domain containing protein 0.024 0.0195 0.0195
Brugia malayi neuroendocrine convertase 1 precursor 0.5327 0.4874 0.4874
Mycobacterium ulcerans Type I modular polyketide synthase 0.0086 0.0054 0.1706
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0369 0.0314 0.0404
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0058 0.0028 0.0812
Loa Loa (eye worm) integrin beta-2 1.09 1 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0143 0.0106 0.0106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2038 0.1849 0.3919
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.001 0.0011
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0099 0.0066 0.2097
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0014
Schistosoma mansoni site-1 peptidase (S08 family) 0.0369 0.0314 0.0404
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0369 0.0314 0.0404
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0091 0.0059 0.1854
Loa Loa (eye worm) WD40 repeat protein 0.0069 0.0039 0.0038
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0042 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.1682 0.1522 0.152
Loa Loa (eye worm) hypothetical protein 0.1564 0.1413 0.1412
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0008
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.005 0.0021 0.0678
Echinococcus multilocularis serine:threonine protein kinase N2 0.0081 0.005 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0035 0.0007 0.0008
Loa Loa (eye worm) transcriptional regulator 0.067 0.0591 0.059
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.006 0.003 0.004
Mycobacterium leprae Polyketide synthase Pks13 0.0129 0.0094 0.2979
Echinococcus multilocularis nmda type glutamate receptor 0.013 0.0094 0.0126
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0068 0.0038 0.1199
Plasmodium falciparum plasmepsin III 0.0035 0.0007 0.0138
Toxoplasma gondii histone deacetylase SIR2-like 0.0099 0.0066 0.2033
Trypanosoma brucei SIR2-like protein 4, putative 0.0099 0.0066 0.0833
Echinococcus multilocularis protein arginine methyltransferase 0.003 0.0003 0.0002
Plasmodium vivax LCCL domain-containing protein 0.0043 0.0015 0.0365
Schistosoma mansoni hypothetical protein 0.0038 0.001 0.0011
Schistosoma mansoni hypothetical protein 0.0038 0.001 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.1669 0.151 0.3199
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0243 0.0198 0.0267
Echinococcus granulosus furin 0.8443 0.774 1
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.067 0.0591 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0091 0.0059 0.1868
Toxoplasma gondii kringle domain-containing protein 0.005 0.0021 0.0586
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0369 0.0314 1
Echinococcus multilocularis Mastin 0.0038 0.001 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0169 0.013 0.4152
Schistosoma mansoni btb and poz domain-containing protein 0.0043 0.0015 0.0018
Loa Loa (eye worm) glutamate receptor 2 0.0066 0.0035 0.0034
Brugia malayi transcriptional regulator, Sir2 family protein 0.067 0.0591 0.0591
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0066 0.0134
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0007 0.0007
Onchocerca volvulus 0.0038 0.001 0.0179
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0008
Plasmodium vivax aspartyl proteinase, putative 0.0035 0.0007 0.0138
Echinococcus granulosus protein kinase c epsilon type 0.0089 0.0057 0.0072
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Loa Loa (eye worm) hypothetical protein 0.0042 0.0013 0.0012
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0064 0.0034 0.1067
Loa Loa (eye worm) hypothetical protein 0.0038 0.001 0.0008
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0066 0.0134
Leishmania major silent information regulator 2, putative 0.067 0.0591 1
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0007 0.0007
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0066 0.0134
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0369 0.0314 0.0404
Schistosoma mansoni apoptosis regulator bax 0.006 0.003 0.0038
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0045 0.0016 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0035 0.0007 0.001
Echinococcus granulosus MAM 0.0067 0.0037 0.0046
Brugia malayi celfurPC protein 0.6773 0.6204 0.6204
Onchocerca volvulus Putative cubilin 0.0039 0.0011 0.0203
Brugia malayi Subtilase family protein 0.0369 0.0314 0.0314
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0369 0.0314 1
Echinococcus multilocularis disintegrin and metalloproteinase 0.0101 0.0067 0.009
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.8443 0.774 1
Echinococcus granulosus integrin alpha ps 0.052 0.0453 0.0584
Loa Loa (eye worm) hypothetical protein 0.0101 0.0067 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0083 0.0051 0.0067
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0066 0.0084
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0091 0.0059 0.1868
Echinococcus granulosus glutamate receptor subunit protein glur 0.0045 0.0016 0.002
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0043 0.0015 0.0026
Loa Loa (eye worm) hypothetical protein 0.0243 0.0198 0.0197
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0099 0.0066 0.0088
Echinococcus granulosus disintegrin and metalloproteinase 0.0101 0.0067 0.0086
Brugia malayi Stress-activated protein kinase jnk-1 0.0243 0.0198 0.0198
Mycobacterium ulcerans Type I modular polyketide synthase 0.0086 0.0054 0.1706
Toxoplasma gondii subtilisin SUB7 0.0369 0.0314 1
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0369 0.0314 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0037 0.0036
Echinococcus granulosus glutamate receptor 2 0.0083 0.0051 0.0064
Schistosoma mansoni site-1 peptidase (S08 family) 0.0369 0.0314 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0369 0.0314 0.0661
Trichomonas vaginalis hypothetical protein 0.024 0.0195 0.0409
Mycobacterium ulcerans monoamine oxidase 0.0101 0.0068 0.215
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.047 0.0407 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0014
Echinococcus multilocularis protein jagged 2 0.024 0.0195 0.0263
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0003 0.0002
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0045 0.0016 0.0021
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.067 0.0591 0.0801
Trichomonas vaginalis conserved hypothetical protein 0.1669 0.151 0.3199
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0083 0.0051 0.0064
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0099 0.0066 0.0833
Loa Loa (eye worm) TK/ROR protein kinase 0.005 0.0021 0.002
Brugia malayi AMP-binding enzyme family protein 0.0083 0.0051 0.0051
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0069 0.0039 0.1233
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0039 0.0011 0.001
Onchocerca volvulus 0.005 0.0021 0.0418
Loa Loa (eye worm) fatty acid synthase 0.0088 0.0055 0.0054
Echinococcus granulosus Tolloid protein 1 0.0039 0.0011 0.0012
Echinococcus multilocularis membrane bound transcription factor site 1 0.0369 0.0314 0.0424
Toxoplasma gondii subtilisin SUB11 0.0369 0.0314 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0073 0.0042 0.0488
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0086 0.0054 0.1719
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0071 0.004 0.0039
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0099 0.0066 0.0185
Echinococcus multilocularis epidermal growth factor receptor 0.0463 0.0401 0.0542
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Leishmania major hypothetical protein, conserved 0.005 0.0021 0.031
Schistosoma mansoni protein arginine N-methyltransferase 1 0.003 0.0003 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Brugia malayi Trypsin family protein 0.0444 0.0383 0.0383
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0089 0.0057 0.0055
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0015 0.0018
Schistosoma mansoni hypothetical protein 0.052 0.0453 0.0584
Echinococcus multilocularis glycoprotein Antigen 5 0.0038 0.001 0.0011
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0083 0.0051 0.1628
Schistosoma mansoni glutamate receptor kainate 0.0066 0.0035 0.0044
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0369 0.0314 1
Loa Loa (eye worm) reprolysin 0.0243 0.0198 0.0197
Toxoplasma gondii subtilisin SUB9 0.0369 0.0314 1
Loa Loa (eye worm) hypothetical protein 0.0444 0.0383 0.0382
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0101 0.0068 0.1939
Trichomonas vaginalis conserved hypothetical protein 0.1669 0.151 0.3199
Trichomonas vaginalis conserved hypothetical protein 0.1669 0.151 0.3199
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0043 0.0015 0.0471
Schistosoma mansoni glutamate receptor kainate 0.0066 0.0035 0.0044
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0083 0.0051 0.005
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0068 0.1939
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0243 0.0198 0.0254
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0101 0.0068 0.215
Echinococcus multilocularis enteropeptidase 0.0038 0.001 0.0011
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0045 0.0016 0.002
Echinococcus multilocularis Tolloid protein 1 0.0039 0.0011 0.0013
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0007 0.0008
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0165 0.0127 0.0127
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0169 0.013 0.0271
Toxoplasma gondii subtilisin SUB4 0.0369 0.0314 1
Loa Loa (eye worm) apoptosis regulator protein 0.006 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0142 0.0105 0.0104
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0101 0.0068 0.0066
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0091 0.0059 0.1868
Schistosoma mansoni protein kinase 0.0143 0.0106 0.0136
Giardia lamblia Neurogenic locus notch-like protein 0.024 0.0195 0.0643
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0056 0.0026 0.0827
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0043 0.0015 0.0018
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0007 0.0006
Schistosoma mansoni hypothetical protein 0.006 0.003 0.0038
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0129 0.0094 0.2991
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0068 0.0038 0.1184
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0086 0.0054 0.1706
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0013 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0394 0.0338 0.5575
Echinococcus multilocularis fibrillin 1 0.0254 0.0209 0.0282
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1564 0.1413 0.1413
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0311 0.0261 0.0353
Schistosoma mansoni septate junction protein 0.0057 0.0027 0.0033
Toxoplasma gondii subtilisin SUB1 0.0369 0.0314 1
Echinococcus granulosus adam 17 protease 0.0101 0.0067 0.0086
Plasmodium vivax NAD-dependent deacetylase, putative 0.0099 0.0066 0.189
Giardia lamblia High cysteine protein 0.024 0.0195 0.0643
Schistosoma mansoni discoidin domain receptor 0.0043 0.0015 0.0018
Echinococcus multilocularis protein kinase c epsilon type 0.0089 0.0057 0.0075
Onchocerca volvulus 0.0083 0.0051 0.1066
Echinococcus multilocularis adam 0.0557 0.0487 0.0659
Schistosoma mansoni chromatin regulatory protein sir2 0.0099 0.0066 0.0084
Chlamydia trachomatis glutamine binding protein 0.0085 0.0053 0.3152
Onchocerca volvulus 0.0038 0.001 0.0179
Mycobacterium ulcerans hypothetical protein 0.0038 0.001 0.0306
Toxoplasma gondii aspartyl protease 0.0035 0.0007 0.0149
Echinococcus granulosus epidermal growth factor receptor 0.0463 0.0401 0.0516
Echinococcus granulosus discoidin domain receptor 0.0043 0.0015 0.0018
Echinococcus granulosus lysine specific histone demethylase 1A 0.0496 0.0431 0.0555
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.067 0.0591 1
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0044 0.0015 0.0019
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0125 0.009 0.009
Brugia malayi Trypsin-like protease protein 5 0.0038 0.001 0.001
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0083 0.0051 0.0064
Toxoplasma gondii subtilisin SUB6 0.0369 0.0314 1
Onchocerca volvulus 0.0154 0.0117 0.2471
Echinococcus multilocularis discoidin domain receptor 0.0043 0.0015 0.0018
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0496 0.0431 0.0555
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0007 0.0006
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5154 0.4715 1
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0101 0.0067 0.009
Loa Loa (eye worm) integrin alpha pat-2 0.3175 0.2895 0.2894
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.001 0.0011
Brugia malayi protein kinase C II. 0.0089 0.0057 0.0057
Brugia malayi transcriptional regulator, Sir2 family protein 0.0099 0.0066 0.0066
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0091 0.0059 0.1868
Loa Loa (eye worm) hypothetical protein 0.0444 0.0383 0.0382
Onchocerca volvulus 0.0043 0.0015 0.0289
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0086 0.0054 0.1706
Echinococcus granulosus neuroendocrine convertase 2 0.5327 0.4874 0.6297
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0169 0.013 0.4141
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0086 0.0054 0.1692
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0085 0.0053 0.3152
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0057 0.0072
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.127 0.1143 0.1476
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Loa Loa (eye worm) hypothetical protein 0.0496 0.0431 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0015 0.0026
Trichomonas vaginalis hypothetical protein 0.0043 0.0015 0.0026
Plasmodium falciparum plasmepsin VIII, putative 0.0035 0.0007 0.0138
Giardia lamblia Transcriptional regulator, Sir2 family 0.0099 0.0066 0.0185
Echinococcus multilocularis integrin alpha ps 0.1085 0.0973 0.1318
Echinococcus multilocularis neuroendocrine convertase 2 0.5327 0.4874 0.6609
Loa Loa (eye worm) hypothetical protein 0.0039 0.0011 0.0009
Echinococcus multilocularis fibrillin 2 0.024 0.0195 0.0263
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0394 0.0338 0.5575
Mycobacterium ulcerans dehydrogenase 0.0101 0.0068 0.215
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0007 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0369 0.0314 0.0661
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0015 0.0365
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0083 0.0051 0.0064
Schistosoma mansoni integrin alpha-ps 0.1085 0.0973 0.1256
Schistosoma mansoni hypothetical protein 0.1669 0.151 0.195
Schistosoma mansoni dihydroceramide desaturase 0.0101 0.0067 0.0086
Schistosoma mansoni furin-1 (S08 family) 0.3658 0.3339 0.4313
Echinococcus multilocularis 0.6773 0.6204 0.8414
Trypanosoma cruzi UDP-galactopyranose mutase 0.0101 0.0068 0.0863
Loa Loa (eye worm) glutamate receptor 1 0.0066 0.0035 0.0034
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0099 0.0066 0.0134
Loa Loa (eye worm) hypothetical protein 0.0067 0.0037 0.0036
Echinococcus granulosus serine:threonine protein kinase N2 0.0073 0.0042 0.0052
Mycobacterium ulcerans Sir2-like regulatory protein 0.0099 0.0066 0.2097
Echinococcus granulosus c-Jun N-terminal kinases 0.0243 0.0198 0.0255
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0015 0.0018
Toxoplasma gondii histone deacetylase SIR2 0.0099 0.0066 0.2033
Brugia malayi proprotein convertase 2 0.5327 0.4874 0.4874
Mycobacterium ulcerans Type I modular polyketide synthase 0.0086 0.0054 0.1706
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0201 0.0159 0.4677
Schistosoma mansoni glutamate receptor AMPA 0.0066 0.0035 0.0044
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0015 0.0018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2038 0.1849 0.3919
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0099 0.0066 0.0084
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0004 0.0105
Loa Loa (eye worm) hypothetical protein 0.024 0.0195 0.0194
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.013 0.0094 0.0126
Plasmodium vivax cysteine repeat modular protein 1, putative 0.005 0.0021 0.0545
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.001 0.0011
Schistosoma mansoni protein kinase 0.0143 0.0106 0.0136
Echinococcus granulosus protein will die slowly 0.0069 0.0039 0.0048
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0369 0.0314 0.0661

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 348 nM Inhibitory activity against human thrombin (using Chromozym TH as the substrate) ChEMBL. 10794696
Ki (binding) = 348 nM Inhibitory activity against human thrombin (using Chromozym TH as the substrate) ChEMBL. 10794696
Ki (binding) = 1785 nM Inhibitory activity against human trypsin (using Chromozym TH as the substrate) ChEMBL. 10794696
Ki (binding) = 1785 nM Inhibitory activity against human trypsin (using Chromozym TH as the substrate) ChEMBL. 10794696

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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