Detailed information for compound 807887

Basic information

Technical information
  • TDR Targets ID: 807887
  • Name: 2,7-diamino-4-thiophen-2-yl-4H-chromene-3-car bonitrile
  • MW: 269.322 | Formula: C14H11N3OS
  • H donors: 2 H acceptors: 1 LogP: 2.33 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)Oc2c(C1c1cccs1)ccc(c2)N
  • InChi: 1S/C14H11N3OS/c15-7-10-13(12-2-1-5-19-12)9-4-3-8(16)6-11(9)18-14(10)17/h1-6,13H,16-17H2
  • InChiKey: GFKDURCPRUHGLE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,7-diamino-4-(2-thienyl)-4H-chromene-3-carbonitrile
  • BIM-0014667.P001
  • ST5448600
  • CBMicro_014706
  • Oprea1_259971
  • Oprea1_197543

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens G protein-coupled receptor kinase 6 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K08291 G protein-coupled receptor kinase [EC2.7.11.16], putative Get druggable targets OG5_130334 All targets in OG5_130334
Loa Loa (eye worm) G protein-coupled receptor kinase 1 Get druggable targets OG5_130334 All targets in OG5_130334
Echinococcus multilocularis G protein coupled receptor kinase 6 Get druggable targets OG5_130334 All targets in OG5_130334
Echinococcus granulosus [G-protein-coupledreceptor] kinase Get druggable targets OG5_130334 All targets in OG5_130334
Schistosoma japonicum G protein-coupled receptor kinase 1, putative Get druggable targets OG5_130334 All targets in OG5_130334
Loa Loa (eye worm) AGC/GRK/GRK protein kinase Get druggable targets OG5_130334 All targets in OG5_130334
Loa Loa (eye worm) AGC/GRK/GRK protein kinase Get druggable targets OG5_130334 All targets in OG5_130334
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130334 All targets in OG5_130334
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative Get druggable targets OG5_130334 All targets in OG5_130334
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative Get druggable targets OG5_130334 All targets in OG5_130334
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0142 0.0148
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0014 0.0277 0.035
Echinococcus multilocularis aldo keto reductase 0.0062 0.175 0.1705
Toxoplasma gondii transcriptional elongation factor FACT140 0.0011 0.0172 0.0482
Leishmania major cytochrome p450-like protein 0.0014 0.0277 0.0913
Mycobacterium ulcerans dipeptidase PepE 0.0011 0.0172 0.0164
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0011 0.0172 0.0172
Plasmodium vivax peptidase, putative 0.0011 0.0172 0.0482
Echinococcus granulosus Regulator of G protein signaling 20 0.0015 0.0317 0.0265
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0011 0.0172 0.0204
Echinococcus granulosus Proliferation associated protein 2G4 0.0011 0.0172 0.0118
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0011 0.0172 0.0482
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0015 0.0317 0.0317
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0054 0.0041
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0092 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0014 0.0277 0.035
Brugia malayi regulator of G-protein signaling egl-10 0.0015 0.0317 0.0439
Schistosoma mansoni apoferritin-2 0.0008 0.01 0.01
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0277 0.031
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0011 0.0172 0.0482
Schistosoma mansoni ferritin 0.0008 0.01 0.01
Echinococcus granulosus ferritin 0.0008 0.01 0.0046
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0014 0.0277 0.031
Echinococcus granulosus voltage gated potassium channel subunit 0.0018 0.0394 0.0342
Echinococcus granulosus FACT complex subunit SPT16 0.0011 0.0172 0.0118
Loa Loa (eye worm) histone methyltransferase 0.001 0.0145 0.0152
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0015 0.0317 0.0265
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0092 0.0092
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0352 0.0454
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0142 0.0088
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0277 0.0913
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0394 0.0516
Brugia malayi CXXC zinc finger family protein 0.0028 0.0717 0.1105
Schistosoma mansoni axis inhibition protein axin 0.0015 0.0317 0.0317
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0142 0.0148
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0139 0.4131 0.4099
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0054 0.0041
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0564 0.0709
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0092 0.0038
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0564 0.0709
Echinococcus multilocularis nibrin 0.001 0.0142 0.0088
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0054 0.0041
Onchocerca volvulus 0.0029 0.0749 0.1014
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0011 0.0172 0.0482
Leishmania major transcription factor-like protein 0.0011 0.0172 0.0482
Schistosoma mansoni hypothetical protein 0.033 1 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0014 0.0277 0.035
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.175 0.1705
Brugia malayi initiation factor 2-associated protein. 0.0086 0.25 0.4076
Trichomonas vaginalis aldo/keto reductase, putative 0.0062 0.175 0.2489
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.175 0.1705
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0317 0.0403
Schistosoma mansoni ferritin light chain 0.0008 0.01 0.01
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0011 0.0172 0.0164
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0277 0.031
Brugia malayi hypothetical protein 0.001 0.0142 0.0146
Echinococcus multilocularis voltage gated potassium channel subunit 0.0018 0.0394 0.0342
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0564 0.2087
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0935 0.0886
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0317 0.0403
Echinococcus multilocularis regulator of G protein signaling 7 0.0015 0.0317 0.0265
Echinococcus granulosus xaa Pro dipeptidase 0.0011 0.0172 0.0118
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0172 0.0192
Echinococcus granulosus xaa Pro dipeptidase 0.0011 0.0172 0.0118
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0062 0.175 0.6934
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0277 0.031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0749 0.0749
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0054 0.0041
Trichomonas vaginalis ferritin, putative 0.0008 0.01 0.0087
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0564 0.0851
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0011 0.0172 0.0482
Echinococcus granulosus regulator of G protein signaling 7 0.0015 0.0317 0.0265
Onchocerca volvulus 0.0062 0.175 0.2474
Echinococcus multilocularis expressed protein 0.0015 0.0317 0.0265
Trypanosoma cruzi aldo/keto reductase, putative 0.0062 0.175 0.6934
Trypanosoma cruzi aminopeptidase P1, putative 0.0011 0.0172 0.0482
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0011 0.0172 0.0482
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0142 0.0142
Mycobacterium tuberculosis Probable oxidoreductase 0.0062 0.175 0.2388
Schistosoma mansoni cpg binding protein 0.003 0.0767 0.0767
Schistosoma mansoni z-protein (S1r protein) 0.0015 0.0317 0.0317
Plasmodium falciparum aminopeptidase P 0.0011 0.0172 0.0482
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0011 0.0172 0.0482
Entamoeba histolytica peptidase, putative 0.0011 0.0172 0.0482
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0382 0.0455
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.1593 0.1547
Entamoeba histolytica hypothetical protein 0.0035 0.0935 0.3603
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0749 0.0749
Echinococcus granulosus nibrin 0.001 0.0142 0.0088
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0697 0.0647
Toxoplasma gondii carbamoylphosphate synthetase 0.0031 0.0805 0.307
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0015 0.0317 0.0317
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0011 0.0172 0.0482
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0329 0.0329
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0564 0.0709
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0014 0.0277 0.035
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0011 0.0172 0.0482
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0011 0.0172 0.0118
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0564 0.0747
Schistosoma mansoni topbp1 0.001 0.0142 0.0142
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0935 0.0886
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0014 0.0277 0.035
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0142 0.0359
Mycobacterium leprae putative cytochrome p450 0.0014 0.0277 0.031
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.01 0.0064
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.175 0.1705
Schistosoma mansoni ferritin light chain 0.0008 0.01 0.01
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0277 0.031
Brugia malayi topoisomerase 0.001 0.0142 0.0146
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0011 0.0172 0.0482
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0277 0.0372
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0277 0.0224
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.175 0.2489
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.01 0.0105
Loa Loa (eye worm) oxidoreductase 0.0062 0.175 0.2826
Entamoeba histolytica aldose reductase, putative 0.0062 0.175 0.6934
Brugia malayi Pre-SET motif family protein 0.0202 0.6054 1
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0011 0.0172 0.0482
Echinococcus multilocularis regulator of G protein signaling 3 0.0015 0.0317 0.0265
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.1593 0.2138
Trypanosoma brucei aldo/keto reductase, putative 0.0018 0.0394 0.1392
Schistosoma mansoni ap endonuclease 0.0019 0.0415 0.0415
Schistosoma mansoni axis inhibition protein axin 0.0015 0.0317 0.0317
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0086 0.25 0.3581
Brugia malayi cytochrome P450 0.0014 0.0277 0.0372
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0011 0.0172 0.0482
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0277 0.031
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0054 0.0041
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0142 0.0359
Loa Loa (eye worm) cytochrome P450 0.0014 0.0277 0.0372
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0142 0.0359
Echinococcus granulosus cpg binding protein 0.003 0.0767 0.0717
Trypanosoma brucei Metallopeptidase family M24, putative 0.0011 0.0172 0.0482
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0277 0.0913
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0086 0.25 1
Echinococcus multilocularis xaa Pro dipeptidase 0.0011 0.0172 0.0118
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0054 0.0041
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0011 0.0172 0.0196
Chlamydia trachomatis aminopeptidase P 0.0011 0.0172 0.1249
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0015 0.0317 0.0439
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0018 0.0394 0.1392
Mycobacterium leprae Possible oxidoreductase 0.0018 0.0394 0.0473
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0011 0.0172 0.0482
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0014 0.0277 0.035
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0011 0.0172 0.0204
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0415 0.1476
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0142 0.0359
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.175 0.1705
Toxoplasma gondii creatinase domain-containing protein 0.0011 0.0172 0.0482
Toxoplasma gondii aldo-keto reductase 0.0018 0.0394 0.1392
Loa Loa (eye worm) hypothetical protein 0.0011 0.0172 0.0196
Brugia malayi hypothetical protein 0.0015 0.0317 0.0439
Echinococcus multilocularis Regulator of G protein signaling 20 0.0015 0.0317 0.0265
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0062 0.175 0.2826
Schistosoma mansoni aldo-keto reductase 0.0062 0.175 0.175
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.175 0.1705
Loa Loa (eye worm) oxidoreductase 0.0062 0.175 0.2826
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.175 0.1705
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.175 0.1705
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0086 0.25 0.25
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0352 0.0454
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0564 0.0709
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0277 0.031
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.175 0.1705
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0172 0.0192
Brugia malayi hypothetical protein 0.0015 0.0317 0.0439
Toxoplasma gondii exonuclease III APE 0.0019 0.0415 0.1476
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0016 0.0329 0.0458
Brugia malayi hypothetical protein 0.001 0.0142 0.0146
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0277 0.031
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0142 0.0148
Echinococcus multilocularis regulator of G protein signaling 7 0.0015 0.0317 0.0265
Onchocerca volvulus 0.0062 0.175 0.2474
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0277 0.031
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0142 0.0148
Treponema pallidum methionine aminopeptidase (map) 0.0011 0.0172 0.2275
Loa Loa (eye worm) hypothetical protein 0.0011 0.0172 0.0196
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.175 0.1705
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0011 0.0172 0.0118
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0054 0.0041
Schistosoma mansoni peptidase 0.0011 0.0172 0.0172
Echinococcus granulosus methionyl aminopeptidase 2 0.0086 0.25 0.2459
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0155 0.4606 0.7588
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0415 1
Leishmania major hypothetical protein, conserved 0.0011 0.0172 0.0482
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.1593 0.2138
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.1593 0.2564
Echinococcus multilocularis beta adrenergic receptor kinase 0.0016 0.0329 0.0276
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0014 0.0277 0.035
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0092 0.0038
Echinococcus granulosus beta-adrenergic receptor kinase 0.0016 0.0329 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0394 0.0516
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0018 0.0394 0.0568
Leishmania major prostaglandin f synthase, putative 0.0062 0.175 0.6934
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0749 0.2843
Entamoeba histolytica hypothetical protein 0.0035 0.0935 0.3603
Plasmodium falciparum aldo-keto reductase, putative 0.0018 0.0394 0.1392
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0277 0.031
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0018 0.0394 0.0568
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0031 0.0805 0.307
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0011 0.0172 0.0482
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0011 0.0172 0.0482
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0011 0.0172 0.0482
Onchocerca volvulus 0.0028 0.0717 0.0967
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0142 0.0148
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0018 0.0394 0.1392
Chlamydia trachomatis methionine aminopeptidase 0.0011 0.0172 0.1249
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0317 0.0403
Echinococcus multilocularis ferritin 0.0008 0.01 0.0046
Echinococcus multilocularis geminin 0.033 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0277 0.0913
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0415 0.0546
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0054 0.002
Schistosoma mansoni hypothetical protein 0.033 1 1
Onchocerca volvulus 0.0018 0.0394 0.0497
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0011 0.0172 0.0172
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0277 0.031
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0086 0.25 0.3581
Brugia malayi Methionine aminopeptidase protein type I 0.0011 0.0172 0.0196
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.1593 0.217
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0054 0.0041
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0139 0.4131 0.6796
Entamoeba histolytica hypothetical protein 0.0035 0.0935 0.3603
Schistosoma mansoni apoferritin-2 0.0008 0.01 0.01
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0394 0.0516
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0014 0.0277 0.035
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.175 0.1705
Loa Loa (eye worm) hypothetical protein 0.0023 0.0564 0.0851
Echinococcus multilocularis 0.0014 0.0277 0.0224
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0011 0.0172 0.0482
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0015 0.0317 0.0265
Echinococcus multilocularis methionine aminopeptidase, type I 0.0011 0.0172 0.0118
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0415 0.0363
Mycobacterium ulcerans oxidoreductase 0.0062 0.175 0.2357
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0317 0.0403
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0564 0.0709
Trypanosoma cruzi aldo/keto reductase, putative 0.0018 0.0394 0.1392
Brugia malayi Cytochrome P450 family protein 0.009 0.2625 0.4285
Loa Loa (eye worm) hypothetical protein 0.001 0.0142 0.0146
Brugia malayi Regulator of G protein signaling domain containing protein 0.0015 0.0317 0.0439
Treponema pallidum aminopeptidase P 0.0011 0.0172 0.2275
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0749 0.0699
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0011 0.0172 0.0196
Echinococcus granulosus regulator of G protein signaling 7 0.0015 0.0317 0.0265
Loa Loa (eye worm) initiation factor 2-associated protein 0.0086 0.25 0.4076
Echinococcus granulosus xaa pro aminopeptidase 0.0011 0.0172 0.0118
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0142 0.0148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0382 0.0546
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0277 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0317 0.0403
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0382 0.0494
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0011 0.0172 0.0172
Onchocerca volvulus 0.0062 0.175 0.2474
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0011 0.0172 0.0482
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0031 0.0805 0.0986
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0142 0.0146
Plasmodium vivax SET domain protein, putative 0.0029 0.0749 0.2843
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0054 0.0041
Loa Loa (eye worm) hypothetical protein 0.0015 0.0317 0.0439
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0277 0.0913
Schistosoma mansoni ferritin 0.0008 0.01 0.01
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0011 0.0172 0.0482
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0142 0.0359
Onchocerca volvulus 0.0229 0.6909 1
Mycobacterium ulcerans hypothetical protein 0.0018 0.0394 0.0473
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0564 0.2087
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0277 0.0372
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0749 0.0699
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0564 0.0747
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0277 0.0913
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0018 0.0394 0.0342
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0014 0.0277 0.035
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.175 0.1705
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0935 0.0935
Brugia malayi Cytochrome P450 family protein 0.0014 0.0277 0.0372
Echinococcus multilocularis axis inhibition protein axin 0.0015 0.0317 0.0265
Loa Loa (eye worm) hypothetical protein 0.0062 0.175 0.2826
Mycobacterium leprae Probable bifunctional purine biosynthesis protein PurH : phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transf 0.0241 0.725 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0382 0.0546
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1532 0.6045
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0011 0.0172 0.0118
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0277 0.031
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0145 0.0092
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0086 0.25 1
Leishmania major carbamoyl-phosphate synthase, putative 0.0031 0.0805 0.307
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0011 0.0172 0.0482
Brugia malayi DKFZp564C0469 protein 0.001 0.0142 0.0146
Entamoeba histolytica hypothetical protein 0.0015 0.0317 0.1076
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0277 0.0913
Wolbachia endosymbiont of Brugia malayi AICAR transformylase/IMP cyclohydrolase PurH 0.0241 0.725 1
Echinococcus granulosus regulator of G protein signaling 3 0.0015 0.0317 0.0265
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0062 0.175 0.2826
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0277 0.031
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0054 0.0054
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0011 0.0172 0.0482
Loa Loa (eye worm) hypothetical protein 0.0018 0.0382 0.0546
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0014 0.0277 0.035
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0382 0.134
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.175 0.1705
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.175 0.2489
Toxoplasma gondii methionine aminopeptidase 0.0011 0.0172 0.0482
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0014 0.0277 0.035
Onchocerca volvulus 0.0011 0.0172 0.0172
Schistosoma mansoni potassium channel beta 0.0018 0.0394 0.0394
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0749 0.0699
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0415 0.054
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.1593 0.1547
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0277 0.031
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1731 0.1731
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0086 0.25 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0415 0.1158
Brugia malayi metallopeptidase family M24 containing protein 0.0011 0.0172 0.0196
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0011 0.0172 0.0482
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0382 1
Plasmodium vivax methionine aminopeptidase 2, putative 0.0086 0.25 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0014 0.0277 0.035
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0086 0.25 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.175 0.1705
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0062 0.175 0.2357
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0011 0.0172 0.0482
Onchocerca volvulus 0.0011 0.0172 0.0172
Toxoplasma gondii methionine aminopeptidase 0.0011 0.0172 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0317 0.0403
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.175 0.2489
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.175 0.1705
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0415 0.044
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0062 0.175 0.2826
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0564 0.0851
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0277 0.0913
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0172 0.0192
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0011 0.0172 0.0172
Brugia malayi Cytochrome P450 family protein 0.0014 0.0277 0.0372
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0014 0.0277 0.035
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0018 0.0394 0.1392
Brugia malayi metallopeptidase family M24 containing protein 0.0011 0.0172 0.0196
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0317 0.0317
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0142 0.0122
Onchocerca volvulus 0.001 0.0142 0.0128
Mycobacterium ulcerans bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 0.0241 0.725 1
Plasmodium vivax aldehyde reductase, putative 0.0018 0.0394 0.1392
Mycobacterium leprae Conserved hypothetical protein 0.0044 0.1197 0.1589
Echinococcus multilocularis xaa Pro dipeptidase 0.0011 0.0172 0.0118
Loa Loa (eye worm) cytochrome P450 family protein 0.009 0.2625 0.4285
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0011 0.0172 0.0172
Loa Loa (eye worm) PXA domain-containing protein 0.0015 0.0317 0.0439
Brugia malayi A-kinase anchor protein 10, precursor 0.0015 0.0317 0.0439
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0086 0.25 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0062 0.175 0.6934
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0564 0.2087
Loa Loa (eye worm) oxidoreductase 0.0062 0.175 0.2826
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0415 0.0602
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0139 0.4131 0.4099
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0086 0.25 0.3581
Echinococcus multilocularis FACT complex subunit SPT16 0.0011 0.0172 0.0118
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0415 0.0502
Echinococcus multilocularis Proliferation associated protein 2G4 0.0011 0.0172 0.0118
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0382 0.134
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.175 0.2489
Leishmania major methionine aminopeptidase 2, putative 0.0086 0.25 1
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0142 0.0146
Loa Loa (eye worm) hypothetical protein 0.0015 0.0317 0.0439
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0011 0.0172 0.0164
Echinococcus granulosus expressed protein 0.0015 0.0317 0.0265
Echinococcus multilocularis cpg binding protein 0.003 0.0767 0.0717
Echinococcus granulosus methionine aminopeptidase type I 0.0011 0.0172 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0749 0.0749
Echinococcus granulosus replication factor c subunit 1 0.001 0.0142 0.0088
Entamoeba histolytica hypothetical protein, conserved 0.0011 0.0172 0.0482
Echinococcus granulosus aldo keto reductase 0.0062 0.175 0.1705
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0564 0.0709
Loa Loa (eye worm) hypothetical protein 0.0015 0.0317 0.0439
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0011 0.0172 0.0172
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0015 0.0317 0.0439
Giardia lamblia Aldose reductase 0.0062 0.175 0.6819
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0564 0.2087
Mycobacterium tuberculosis Dipeptidase PepE 0.0011 0.0172 0.0204
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0011 0.0172 0.0118
Mycobacterium ulcerans dipeptidase 0.0011 0.0172 0.0164
Entamoeba histolytica hypothetical protein 0.001 0.0142 0.0359
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0277 0.031
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.175 0.2489
Onchocerca volvulus 0.0062 0.175 0.2474
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0277 0.031
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0155 0.4606 0.7588
Onchocerca volvulus 0.0062 0.175 0.2474
Brugia malayi PXA domain containing protein 0.0015 0.0317 0.0439
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0564 0.2087
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0011 0.0172 0.0172
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0014 0.0277 0.035
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.01 0.0064
Schistosoma mansoni aspartate carbamoyltransferase 0.0031 0.0805 0.0805
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0142 0.0122
Schistosoma mansoni ap endonuclease 0.0019 0.0415 0.0415
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0011 0.0172 0.0482
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0062 0.175 0.2826
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.01 0.0064
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0062 0.175 0.2489
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0014 0.0277 0.035
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0011 0.0172 0.0482
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0086 0.25 0.3581
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0277 0.0372
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0352 0.0454
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0031 0.0805 0.1044
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0011 0.0172 0.0118
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0014 0.0277 0.035
Schistosoma mansoni hypothetical protein 0.0014 0.0277 0.0277
Brugia malayi Regulator of G protein signaling domain containing protein 0.0015 0.0317 0.0439
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0011 0.0172 0.0482
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0145 0.0092
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0277 0.031
Mycobacterium tuberculosis Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transfo 0.0241 0.725 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0277 0.0913
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.175 0.1705
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0011 0.0172 0.0204
Brugia malayi NADH-dependent xylose reductase 0.0018 0.0394 0.0568
Loa Loa (eye worm) hypothetical protein 0.001 0.0142 0.0146
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0317 0.0317
Loa Loa (eye worm) hypothetical protein 0.001 0.0142 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0014 0.0277 0.035
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0142 0.0058
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0564 0.2087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0172 0.0196
Loa Loa (eye worm) RGS-3 protein 0.0015 0.0317 0.0439
Echinococcus multilocularis aldehyde reductase 0.0044 0.1197 0.1149
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.175 0.2489
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0564 0.0709
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0011 0.0172 0.0482
Schistosoma mansoni aldo-keto reductase 0.0062 0.175 0.175
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0011 0.0172 0.0482
Echinococcus multilocularis aldo keto reductase 0.0062 0.175 0.1705
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0014 0.0277 0.035
Loa Loa (eye worm) hypothetical protein 0.0015 0.0317 0.0439
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0011 0.0172 0.0164
Brugia malayi PXA domain containing protein 0.0015 0.0317 0.0439
Mycobacterium ulcerans hypothetical protein 0.0023 0.0564 0.0709
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0142 0.0148
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0015 0.0317 0.0403
Echinococcus granulosus axis inhibition protein axin 0.0015 0.0317 0.0265
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0415 0.0363
Entamoeba histolytica aldose reductase, putative 0.0062 0.175 0.6934
Trypanosoma brucei prostaglandin f synthase 0.0062 0.175 0.6934
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0415 0.1476
Entamoeba histolytica methionine aminopeptidase, putative 0.0086 0.25 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0142 0.0146
Trichomonas vaginalis aldo/keto reductase, putative 0.0062 0.175 0.2489
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0054 0.002
Schistosoma mansoni DNA ligase IV 0.001 0.0142 0.0142
Mycobacterium tuberculosis Conserved protein 0.0018 0.0394 0.0512
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0011 0.0172 0.0164
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0317 0.0317
Giardia lamblia Methionine aminopeptidase 0.0086 0.25 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0564 0.0851
Entamoeba histolytica hypothetical protein 0.0015 0.0317 0.1076
Trypanosoma cruzi aldo-keto reductase 0.0062 0.175 0.6934
Schistosoma mansoni ferritin 0.0008 0.01 0.01
Echinococcus multilocularis xaa pro aminopeptidase 0.0011 0.0172 0.0118
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0415 0.1476
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0277 0.031
Leishmania major cytochrome p450-like protein 0.0014 0.0277 0.0913
Loa Loa (eye worm) hypothetical protein 0.0018 0.0382 0.0546
Echinococcus multilocularis aldo keto reductase 0.0062 0.175 0.1705
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0.0394 0.0516
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.175 0.2489
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.175 0.1705
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0172 0.0192
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.01 0.0105
Loa Loa (eye worm) oxidoreductase 0.0062 0.175 0.2826
Loa Loa (eye worm) DNA-binding protein 0.0011 0.0172 0.0196
Loa Loa (eye worm) hypothetical protein 0.0023 0.0564 0.0851
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0011 0.0172 0.0482
Echinococcus multilocularis regulator of G protein signaling 0.0015 0.0317 0.0265
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0142 0.0359
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0011 0.0172 0.0172
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0564 0.0709
Onchocerca volvulus 0.0062 0.175 0.2474
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0086 0.25 0.3568
Brugia malayi metallopeptidase family M24 containing protein 0.0011 0.0172 0.0196
Echinococcus granulosus expressed protein 0.0008 0.01 0.0046
Plasmodium vivax FACT complex subunit SPT16, putative 0.0011 0.0172 0.0482
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0277 0.031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0749 0.0749
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0277 0.0913
Toxoplasma gondii peptidase D, putative 0.0011 0.0172 0.0482
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0172 0.0192
Echinococcus granulosus regulator of G protein signaling 3 0.0015 0.0317 0.0265
Brugia malayi Pre-SET motif family protein 0.0029 0.0749 0.1159
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0011 0.0172 0.0172
Schistosoma mansoni cytochrome P450 0.0014 0.0277 0.0277
Brugia malayi hypothetical protein 0.0035 0.0935 0.1469
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.1593 0.6291
Onchocerca volvulus Dipeptidase C homolog 0.0011 0.0172 0.0172
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0142 0.0146
Echinococcus multilocularis axis inhibition protein axin 0.0015 0.0317 0.0265
Giardia lamblia Xaa-Pro dipeptidase 0.0011 0.0172 0.0127
Onchocerca volvulus 0.0023 0.0564 0.0744
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0277 0.031
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.175 0.2489
Echinococcus multilocularis expressed protein 0.0008 0.01 0.0046
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.175 0.2489
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0092 0.0038
Mycobacterium leprae Conserved hypothetical protein 0.0014 0.0277 0.031
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0062 0.175 0.2489
Treponema pallidum DNA ligase (lig) 0.001 0.0142 0.1324
Schistosoma mansoni topbp1 0.001 0.0142 0.0142
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0011 0.0172 0.0164
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.175 0.2489
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0415 0.0546
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0317 0.0317
Giardia lamblia Xaa-Pro dipeptidase 0.0011 0.0172 0.0127
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0011 0.0172 0.0482
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0054 0.0041
Schistosoma mansoni hypothetical protein 0.0035 0.0935 0.0935
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0564 0.0851
Entamoeba histolytica hypothetical protein 0.0015 0.0317 0.1076
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0018 0.0394 0.0516
Entamoeba histolytica alcohol dehydrogenase, putative 0.0018 0.0394 0.1392
Echinococcus granulosus hypothetical protein 0.0062 0.175 0.1705
Echinococcus granulosus axis inhibition protein axin 0.0015 0.0317 0.0265
Entamoeba histolytica aldose reductase, putative 0.0062 0.175 0.6934
Brugia malayi Cytochrome P450 family protein 0.0014 0.0277 0.0372
Entamoeba histolytica aminopeptidase, putative 0.0011 0.0172 0.0482
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0172 0.0192
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.1475 0.2368
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0142 0.0359
Trypanosoma brucei aldo-keto reductase, putative 0.0062 0.175 0.6934
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0415 0.1476
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.175 0.2489
Schistosoma mansoni pol-related 0.0062 0.175 0.175
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.4606 0.4606
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0011 0.0172 0.0482
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0011 0.0172 0.0482
Trichomonas vaginalis set domain proteins, putative 0.0229 0.6909 1
Trypanosoma cruzi aminopeptidase P, putative 0.0011 0.0172 0.0482
Plasmodium falciparum methionine aminopeptidase 2 0.0086 0.25 1
Brugia malayi regulator of G-protein signaling rgs-7 0.0015 0.0317 0.0439
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0415 0.1476
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0011 0.0172 0.0482
Echinococcus multilocularis aldo keto reductase 0.0062 0.175 0.1705
Trichomonas vaginalis aldo/keto reductase, putative 0.0062 0.175 0.2489
Mycobacterium ulcerans aminopeptidase 0.0011 0.0172 0.0164
Trichomonas vaginalis aldo-keto reductase, putative 0.0062 0.175 0.2489
Echinococcus granulosus aldo keto reductase 0.0062 0.175 0.1705
Schistosoma mansoni cpg binding protein 0.0028 0.0717 0.0717
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.175 0.1705
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0352 0.0454
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0172 0.0192
Schistosoma mansoni cpg binding protein 0.003 0.0767 0.0767
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0415 0.0602
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0011 0.0172 0.01
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0139 0.4131 0.6796
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0062 0.175 0.1705
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.1593 0.1593
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0014 0.0277 0.035
Echinococcus multilocularis regulator of G protein signaling 3 0.0015 0.0317 0.0265
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0015 0.0317 0.0317
Leishmania major aldo-keto reductase-like protein 0.0062 0.175 0.6934
Echinococcus granulosus aldehyde reductase 0.0044 0.1197 0.1149
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0011 0.0172 0.01
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.6054 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0142 0.0146
Plasmodium falciparum aldehyde reductase, putative 0.0018 0.0394 0.1392
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0014 0.0277 0.035
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0142 0.0359
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0142 0.0359
Giardia lamblia Aldose reductase 0.0062 0.175 0.6819
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0018 0.0394 0.1392
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0011 0.0172 0.0482
Echinococcus multilocularis methionyl aminopeptidase 2 0.0086 0.25 0.2459
Loa Loa (eye worm) hypothetical protein 0.0018 0.0382 0.0546
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0717 0.1105
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0172 0.0192
Loa Loa (eye worm) hypothetical protein 0.001 0.0142 0.0146
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0054 0.0041
Echinococcus granulosus aldo keto reductase 0.0062 0.175 0.1705
Plasmodium falciparum carbamoyl phosphate synthetase 0.0031 0.0805 0.307
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0415 0.1476
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0142 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0142 0.0148
Leishmania major cytochrome p450-like protein 0.0014 0.0277 0.0913
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.175 0.1705
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0172 0.0192
Loa Loa (eye worm) methionine aminopeptidase type I 0.0011 0.0172 0.0196
Mycobacterium ulcerans methionine aminopeptidase 0.0011 0.0172 0.0164
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0062 0.175 0.1705
Loa Loa (eye worm) oxidoreductase 0.0062 0.175 0.2826
Loa Loa (eye worm) hypothetical protein 0.0015 0.0317 0.0439
Schistosoma mansoni ferritin 0.0008 0.01 0.01
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0415 0.1476
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0139 0.4131 0.6796
Trypanosoma brucei methionine aminopeptidase, putative 0.0011 0.0172 0.0482
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0564 0.0709
Entamoeba histolytica alcohol dehydrogenase, putative 0.0018 0.0394 0.1392
Entamoeba histolytica hypothetical protein 0.0035 0.0935 0.3603
Schistosoma mansoni regulator of G protein signaling 0.0015 0.0317 0.0317
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0142 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0142 0.0148
Loa Loa (eye worm) hypothetical protein 0.0029 0.0749 0.1159
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0062 0.175 0.2489
Toxoplasma gondii aldose reductase, putative 0.0062 0.175 0.6934

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 11.77 uM Inhibition of human recombinant full-length GST-tagged human GRK6 using peptide substrate peptide-216 incubated for 7 hrs ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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