Detailed information for compound 831536

Basic information

Technical information
  • TDR Targets ID: 831536
  • Name: N-[2-(3,4-dimethoxyphenyl)ethyl]-3-[3-(triflu oromethyl)phenyl]triazolo[1,5-a]quinazolin-5- amine
  • MW: 493.48 | Formula: C26H22F3N5O2
  • H donors: 1 H acceptors: 3 LogP: 5.88 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(CCNc2nc3c(nnn3c3c2cccc3)c2cccc(c2)C(F)(F)F)ccc1OC
  • InChi: 1S/C26H22F3N5O2/c1-35-21-11-10-16(14-22(21)36-2)12-13-30-24-19-8-3-4-9-20(19)34-25(31-24)23(32-33-34)17-6-5-7-18(15-17)26(27,28)29/h3-11,14-15H,12-13H2,1-2H3,(H,30,31)
  • InChiKey: QFMWIIYABYWUKH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(3,4-dimethoxyphenyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-5-triazolo[1,5-a]quinazolinamine
  • 2-(3,4-dimethoxyphenyl)ethyl-[3-[3-(trifluoromethyl)phenyl]triazolo[1,5-a]quinazolin-5-yl]amine
  • N-[2-(3,4-dimethoxyphenyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-[1,2,3]triazolo[1,5-a]quinazolin-5-amine
  • C680-0590
  • NCGC00111659-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0004 0.0001
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0153 0.0153
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.054 0.1548 0.1544
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0182 0.0182
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0952 0.3395
Onchocerca volvulus 0.054 0.1548 0.5474
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0523 0.1496 0.5344
Echinococcus granulosus 7TM GPCR rhodopsin 0.054 0.1548 0.1544
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0187 0.0478
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0013 0.0009
Schistosoma mansoni hypothetical protein 0.005 0.0106 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0952 0.3395
Echinococcus granulosus Solute carrier family 22 5 0.1011 0.2932 0.2929
Onchocerca volvulus Putative chitinase 0.0033 0.0053 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0234 0.0821
Echinococcus multilocularis biogenic amine (5HT) receptor 0.054 0.1548 0.1544
Schistosoma mansoni histamine h1 receptor 0.054 0.1548 0.1544
Loa Loa (eye worm) hypothetical protein 0.0074 0.0176 0.0176
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0013 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0952 0.3395
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0105 0.0262
Brugia malayi jmjC domain containing protein 0.0059 0.0132 0.0132
Echinococcus multilocularis Glycoside hydrolase, chitinase domain containing protein 1 0.0033 0.0053 0.005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Loa Loa (eye worm) hypothetical protein 0.0448 0.1277 0.1277
Brugia malayi G protein-coupled receptor F59B2.13 0.054 0.1548 0.1548
Echinococcus granulosus biogenic amine 5HT receptor 0.054 0.1548 0.1544
Brugia malayi jmjC domain containing protein 0.0016 0.0004 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0952 0.3395
Loa Loa (eye worm) hypothetical protein 0.0073 0.0171 0.0171
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0028 0.004 0.0094
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0123 0.0123
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0171 0.1264
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0082 0.0278
Echinococcus multilocularis neuropeptide receptor A26 0.054 0.1548 0.1544
Loa Loa (eye worm) inositol-1 0.0036 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0031 0.0048 0.0044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.0493 0.0493
Onchocerca volvulus 0.054 0.1548 0.5474
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Echinococcus multilocularis G protein coupled receptor 139 0.054 0.1548 0.1544
Brugia malayi G-protein coupled receptor 0.054 0.1548 0.1548
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0015 0.0011
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0448 0.1277 0.1274
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Loa Loa (eye worm) melatonin receptor type 1A 0.054 0.1548 0.1548
Brugia malayi Serotonin receptor 0.054 0.1548 0.1548
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0077 0.0185 0.0537
Brugia malayi hypothetical protein 0.054 0.1548 0.1548
Schistosoma mansoni hypothetical protein 0.0035 0.0061 0.0057
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0848 0.2452 0.2452
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0004
Schistosoma mansoni growth hormone secretagogue receptor 0.054 0.1548 0.1544
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0067 0.0224
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0382 0.0986
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0014 0.0027
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0584 0.1676 0.5987
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0382 0.0986
Leishmania major hypothetical protein, conserved 0.0075 0.0177 0.0451
Schistosoma mansoni hypothetical protein 0.0324 0.091 0.0907
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.054 0.1548 0.1548
Echinococcus granulosus sodium channel protein 0.0037 0.0065 0.0061
Onchocerca volvulus 0.054 0.1548 0.5474
Echinococcus granulosus rhodopsin orphan GPCR 0.054 0.1548 0.1544
Echinococcus granulosus snurportin 1 0.0324 0.091 0.0907
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Brugia malayi Cytochrome P450 family protein 0.0054 0.0116 0.0116
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0023 0.0029
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0042 0.0057
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0448 0.1277 0.1277
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.003 0.0067
Entamoeba histolytica hypothetical protein 0.0025 0.003 0.0183
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0135
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0048 0.0044
Onchocerca volvulus Putative endochitinase 0.0222 0.0609 0.2075
Brugia malayi Adenylyl cyclase protein 0.0077 0.0185 0.0185
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0013 0.0009
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.054 0.1548 0.1544
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0028 0.004 0.0515
Loa Loa (eye worm) hypothetical protein 0.0189 0.0513 0.0513
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0067 0.0224
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.1321 0.3843 0.3841
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Schistosoma mansoni importin beta-1 0.003 0.0047 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0105 0.0359
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0004 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0315 0.0311
Schistosoma mansoni neuropeptide receptor 0.054 0.1548 0.1544
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0063 0.0154
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0014 0.0036
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.005
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0105 0.0144
Entamoeba histolytica chitinase, putative 0.0222 0.0609 0.6352
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0048 0.0048
Schistosoma mansoni biogenic amine receptor 0.054 0.1548 0.1544
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0015 0.0011
Mycobacterium ulcerans beta-lactamase 0.0073 0.0171 0.3136
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0028 0.004 0.0271
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0028 0.004 0.0515
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Trypanosoma cruzi hypothetical protein, conserved 0.0448 0.1277 0.3316
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0448 0.1277 1
Trichomonas vaginalis ran, putative 0.0022 0.0023 0.0067
Mycobacterium ulcerans putative regulatory protein 0.0067 0.0156 0.2834
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.0493 0.0493
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0584 0.1676 0.1673
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0063 0.021
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.054 0.1548 0.1544
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0244 0.0244
Echinococcus granulosus lamin dm0 0.0027 0.0037 0.0033
Echinococcus multilocularis neuropeptide Y receptor 0.054 0.1548 0.1544
Schistosoma mansoni rhodopsin-like orphan GPCR 0.054 0.1548 0.1544
Mycobacterium tuberculosis Conserved protein 0.0073 0.0171 0.1264
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0004 0.0001
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0024 0.0052
Entamoeba histolytica Ran family GTPase 0.0022 0.0023 0.0112
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0187 0.0478
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0448 0.1277 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0448 0.1277 0.1911
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0151
Brugia malayi TAR-binding protein 0.0076 0.0182 0.0182
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0171 0.1264
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.2277 0.6657 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0463 0.1321 1
Schistosoma mansoni hypothetical protein 0.0031 0.0048 0.0044
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0234 0.0598
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0028 0.004 0.0271
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0516 0.1475 0.5268
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0448 0.1277 0.3316
Onchocerca volvulus 0.0073 0.0171 0.0485
Schistosoma mansoni hypothetical protein 0.054 0.1548 0.1544
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0067 0.0495
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.054 0.1548 0.1544
Schistosoma mansoni neuropeptide F-like receptor 0.054 0.1548 0.1544
Echinococcus multilocularis importin subunit beta 1 0.003 0.0047 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.0493 0.0489
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.027 0.251
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0077 0.0185 0.0537
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0132 0.0128
Onchocerca volvulus 0.0965 0.2796 1
Loa Loa (eye worm) PDE1B protein 0.3413 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.054 0.1548 0.1544
Brugia malayi Importin beta-1 subunit 0.003 0.0047 0.0047
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0013 0.0009
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0658 0.1894 0.4924
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.054 0.1548 0.1544
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0013 0.0009
Echinococcus multilocularis neuropeptides capa receptor 0.054 0.1548 0.1544
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Onchocerca volvulus 0.054 0.1548 0.5474
Schistosoma mansoni inositol monophosphatase 0.0036 0.0063 0.0059
Plasmodium falciparum phosphodiesterase gamma, putative 0.0448 0.1277 1
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0448 0.1277 0.4558
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0097 0.0244 0.0244
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0952 0.3395
Loa Loa (eye worm) glycosyl hydrolase family 18 protein 0.0033 0.0053 0.0053
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0165 0.0443 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0013 0.0009
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0448 0.1277 0.4558
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.0493 0.0489
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0165 0.0443 0.3334
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0063 0.021
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0018 0.0009 0.0005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0448 0.1277 0.1911
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0165 0.0443 0.8597
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0001
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0952 0.3395
Loa Loa (eye worm) hypothetical protein 0.2277 0.6657 0.6657
Loa Loa (eye worm) RecQ helicase 0.0042 0.0082 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0171 0.0435
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0013 0.0009
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0105 0.0151
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0171 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0234 0.0821
Onchocerca volvulus 0.054 0.1548 0.5474
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.2277 0.6657 0.6656
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0063 0.0154
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0234 0.0234
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0028 0.004 0.0271
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0234 0.0821
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0023
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0122 0.0315 0.0311
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.054 0.1548 0.1544
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0048 0.0048
Echinococcus multilocularis GPCR, family 2 0.0031 0.0048 0.0044
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Schistosoma mansoni rhodopsin-like orphan GPCR 0.054 0.1548 0.1544
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0105 0.0359
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0013 0.0013
Brugia malayi RNA binding protein 0.0076 0.0182 0.0182
Brugia malayi Pre-SET motif family protein 0.0122 0.0315 0.0315
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0357 0.1261
Echinococcus multilocularis sex peptide receptor 0.054 0.1548 0.1544
Trichomonas vaginalis chitinase, putative 0.0033 0.0053 0.0176
Brugia malayi hypothetical protein 0.054 0.1548 0.1548
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0028 0.004 0.0515
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0105 0.0101
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0171 0.0167
Echinococcus granulosus peptide allatostatin:somatostatin 0.054 0.1548 0.1544
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0584 0.1676 0.4356
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0067 0.1053
Brugia malayi jmjC domain containing protein 0.0016 0.0004 0.0004
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0448 0.1277 0.1277
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0013 0.0009
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0048 0.0044
Giardia lamblia DINP protein human, muc B family 0.0019 0.0014 0.0008
Echinococcus granulosus g-protein coupled receptor 0.054 0.1548 0.1544
Trypanosoma cruzi hypothetical protein, conserved 0.0448 0.1277 0.3316
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.0402 0.0402
Brugia malayi putative neuropeptide receptor 0.054 0.1548 0.1548
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0037 0.0067 0.0496
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Echinococcus granulosus rhodopsin orphan GPCR 0.054 0.1548 0.1544
Onchocerca volvulus 0.054 0.1548 0.5474
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Schistosoma mansoni hypothetical protein 0.054 0.1548 0.1544
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Loa Loa (eye worm) hypothetical protein 0.0164 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Brugia malayi hypothetical protein 0.0164 0.0439 0.0439
Loa Loa (eye worm) cytochrome P450 0.0028 0.004 0.004
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0067 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0171 0.1264
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0013 0.0009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0041 0.0055
Echinococcus granulosus g protein coupled receptor 0.054 0.1548 0.1544
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.027 0.2744
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0448 0.1277 0.1911
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.0302 0.0298
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0048 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0493 0.0489
Onchocerca volvulus 0.054 0.1548 0.5474
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0132 0.0128
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0015 0.0011
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0013 0.0029
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0448 0.1277 0.1274
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0015 0.0015
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0063 0.0974
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0234 0.023
Echinococcus granulosus somatostatin receptor 0.054 0.1548 0.1544
Loa Loa (eye worm) hypothetical protein 0.0122 0.0315 0.0315
Loa Loa (eye worm) cuticular endochitinase 0.0222 0.0609 0.0609
Brugia malayi Serotonin/octopamine receptor family protein 7 0.054 0.1548 0.1548
Echinococcus granulosus neuropeptide s receptor 0.054 0.1548 0.1544
Schistosoma mansoni rhodopsin-like orphan GPCR 0.054 0.1548 0.1544
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0357 0.1261
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Schistosoma mansoni amine GPCR 0.054 0.1548 0.1544
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0067 0.0063
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0448 0.1277 0.4558
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.008 0.027
Schistosoma mansoni neuropeptide F-like receptor 0.054 0.1548 0.1544
Brugia malayi cytochrome P450 0.0028 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Schistosoma mansoni amine GPCR 0.054 0.1548 0.1544
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0075 0.0177 0.0451
Leishmania major cAMP-specific phosphodiesterase, putative 0.0658 0.1894 0.4924
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0122 0.0315 0.0311
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0028 0.004 0.0515
Schistosoma mansoni myosin xvIII 0.054 0.1548 0.1544
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0132 0.0132
Echinococcus granulosus importin subunit beta 1 0.003 0.0047 0.0043
Onchocerca volvulus Putative endochitinase 0.0222 0.0609 0.2075
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0523 0.1496 0.5344
Brugia malayi G-protein coupled receptor 0.054 0.1548 0.1548
Loa Loa (eye worm) hypothetical protein 0.0685 0.1972 0.1972
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.008 0.0197
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0013 0.0013
Brugia malayi hypothetical protein 0.054 0.1548 0.1548
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0171 0.0167
Echinococcus multilocularis neuropeptide receptor 0.054 0.1548 0.1544
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0373 0.0369
Brugia malayi hypothetical protein 0.0033 0.0053 0.0053
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0013 0.0009
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2277 0.6657 0.6656
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0004 0.0001
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0028 0.004 0.0515
Toxoplasma gondii GAF domain-containing protein 0.0067 0.0156 0.0228
Brugia malayi PXA domain containing protein 0.0019 0.0013 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0234 0.0821
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.0855 0.2217
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0105 0.0262
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0042 0.0299
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0448 0.1277 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0156 0.0156
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0069 0.0605
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Mycobacterium tuberculosis Conserved hypothetical protein 0.0075 0.0177 0.131
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0448 0.1277 0.4558
Echinococcus granulosus GPCR family 2 0.0031 0.0048 0.0044
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0448 0.1277 0.1911
Echinococcus granulosus lamin 0.0027 0.0037 0.0033
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0047 0.0111
Echinococcus multilocularis neuropeptide FF receptor 2 0.054 0.1548 0.1544
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.054 0.1548 0.1544
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0584 0.1676 0.1673
Brugia malayi jmjC domain containing protein 0.0016 0.0004 0.0004
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0029 0.0042 0.0099
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0014 0.0014
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0028 0.004 0.0515
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0244 0.0244
Schistosoma mansoni amine GPCR 0.054 0.1548 0.1544
Schistosoma mansoni inositol monophosphatase 0.0036 0.0063 0.0059
Echinococcus granulosus 7tm_1 domain containing protein 0.054 0.1548 0.1544
Schistosoma mansoni peptide (allatostatin)-like receptor 0.054 0.1548 0.1544
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.054 0.1548 0.1548
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0004
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0069 0.0515
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0659 0.1896 0.6773
Brugia malayi hypothetical protein 0.054 0.1548 0.1548
Onchocerca volvulus 0.054 0.1548 0.5474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.054 0.1548 0.1544
Echinococcus multilocularis rhodopsin orphan GPCR 0.054 0.1548 0.1544
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0584 0.1676 0.1673
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.2277 0.6657 0.6656
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0042 0.0057
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0037 0.0065 0.016
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0182 0.0179
Loa Loa (eye worm) hypothetical protein 0.0034 0.0057 0.0057
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0105 0.0101
Schistosoma mansoni ap endonuclease 0.0037 0.0067 0.0063
Brugia malayi Melatonin receptor type 1A 0.054 0.1548 0.1548
Onchocerca volvulus 0.054 0.1548 0.5474
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0013 0.0009
Plasmodium falciparum GAF domain-related protein, putative 0.0067 0.0156 0.1193
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0013 0.0029
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.054 0.1548 0.1544
Echinococcus granulosus g protein coupled receptor 0.054 0.1548 0.1544
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0234 0.0713
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.054 0.1548 0.1544
Schistosoma mansoni lamin 0.0027 0.0037 0.0033
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0042 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0448 0.1277 0.4558
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0135
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.1183 0.344 0.3437
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0584 0.1676 0.5987
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0047 0.0064
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0105 0.0101
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.1829 0.5338 0.5338
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0028 0.004 0.0515
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0067 0.0067
Echinococcus granulosus thyrotropin releasing hormone receptor 0.054 0.1548 0.1544
Mycobacterium ulcerans putative regulatory protein 0.0067 0.0156 0.2834
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0015 0.0015
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0013 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0004
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.054 0.1548 0.1548
Echinococcus multilocularis expressed protein 0.0365 0.1032 0.1029
Schistosoma mansoni neuropeptide receptor 0.054 0.1548 0.1544
Toxoplasma gondii hypothetical protein 0.0049 0.0102 0.0148
Echinococcus granulosus allatostatin A receptor 0.054 0.1548 0.1544
Echinococcus granulosus adenylate cyclase 9 0.0077 0.0185 0.0181
Mycobacterium ulcerans hypothetical protein 0.0161 0.043 0.8334
Mycobacterium ulcerans lipase LipD 0.0073 0.0171 0.3136
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0584 0.1676 0.4356
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0067 0.0063
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.003 0.0091
Onchocerca volvulus 0.0077 0.0185 0.0537
Loa Loa (eye worm) hypothetical protein 0.0073 0.0171 0.0171
Brugia malayi putative neuropeptide receptor NPR1 0.054 0.1548 0.1548
Leishmania major hypothetical protein, conserved 0.0448 0.1277 0.3316
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0584 0.1676 0.5987
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0132 0.0128
Treponema pallidum fructose-bisphosphate aldolase 0.0338 0.0952 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0042 0.0135
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0084 0.0208
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0315 0.0311
Brugia malayi Pre-SET motif family protein 0.0848 0.2452 0.2452
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.3413 1 1
Onchocerca volvulus Putative endochitinase 0.0222 0.0609 0.2075
Echinococcus multilocularis adenylate cyclase 9 0.0077 0.0185 0.0181
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.2279 0.6664 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.0048
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0013 0.0013
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.027 0.0953
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.0855 0.2217
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0516 0.1475 0.1472
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0448 0.1277 0.3316
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0123 0.0119
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0182 0.0179
Echinococcus multilocularis somatostatin receptor 0.054 0.1548 0.1544
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1321 0.3843 0.5764
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Brugia malayi gonadotropin-releasing hormone receptor 2 0.054 0.1548 0.1548
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0584 0.1676 0.5987
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0067 0.0087
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0132 0.0128
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0448 0.1277 0.1911
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0018 0.0009 0.0005
Echinococcus multilocularis allatostatin A receptor 0.054 0.1548 0.1544
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0448 0.1277 0.3316
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0028 0.004 0.0271
Echinococcus multilocularis neuropeptide receptor 0.054 0.1548 0.1544
Brugia malayi PXA domain containing protein 0.0019 0.0013 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0135
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.027 0.2744
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.027 0.0267
Brugia malayi RNA, U transporter 1 0.0086 0.0211 0.0211
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0013 0.0009
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.008 0.0076
Echinococcus granulosus bloom syndrome protein 0.0042 0.0082 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0234 0.0821
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.027 0.5132
Schistosoma mansoni intermediate filament proteins 0.0027 0.0037 0.0033
Mycobacterium tuberculosis Conserved protein 0.0073 0.0171 0.1264
Schistosoma mansoni lamin 0.0027 0.0037 0.0033
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0171 0.1264
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0448 0.1277 0.1274
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0584 0.1676 0.5987
Schistosoma mansoni cytochrome P450 0.0028 0.004 0.0036
Loa Loa (eye worm) hypothetical protein 0.0073 0.0171 0.0171
Loa Loa (eye worm) beta-lactamase 0.0073 0.0171 0.0171
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0028 0.004 0.0515
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0187 0.0478
Giardia lamblia Fructose-bisphosphate aldolase 0.0338 0.0952 0.1419
Brugia malayi hypothetical protein 0.054 0.1548 0.1548
Brugia malayi hypothetical protein 0.054 0.1548 0.1548
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0028 0.004 0.0515
Loa Loa (eye worm) phosphofructokinase 0.0106 0.027 0.027
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.1829 0.5338 0.5338
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0014 0.001
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0063 0.0089
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Echinococcus granulosus expressed protein 0.0365 0.1032 0.1029
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0014 0.0027
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0373 0.0373
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0171 0.0596
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.3413 1 1
Mycobacterium leprae conserved hypothetical protein 0.0067 0.0156 0.287
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0028 0.004 0.0271
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0084 0.0208
Onchocerca volvulus 0.054 0.1548 0.5474
Mycobacterium leprae Probable lipase LipE 0.0073 0.0171 0.3243
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0028 0.004 0.0515
Schistosoma mansoni rhodopsin-like orphan GPCR 0.054 0.1548 0.1544
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0023 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.0047
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0021
Brugia malayi jmjC domain containing protein 0.0016 0.0004 0.0004
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.027 0.0267
Mycobacterium ulcerans chitinase/cellulase 0.0189 0.0513 1
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Echinococcus multilocularis lamin 0.0027 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0033 0.0053 0.0053
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0142 0.0375 0.7233
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0063 0.0536
Echinococcus granulosus neuropeptide Y receptor 0.054 0.1548 0.1544
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Brugia malayi Inositol-1 0.0036 0.0063 0.0063
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0685 0.1972 0.1968
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0037 0.0037
Brugia malayi AKH receptor 0.054 0.1548 0.1548
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0028 0.004 0.0515
Leishmania major hypothetical protein, conserved 0.0448 0.1277 0.3316
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0028 0.004 0.0271
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Onchocerca volvulus 0.054 0.1548 0.5474
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0013 0.0009
Schistosoma mansoni neuropeptide f receptor 76f 0.054 0.1548 0.1544
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0122 0.0315 0.0311
Echinococcus granulosus fmrfamide receptor 0.054 0.1548 0.1544
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0685 0.1972 0.1972
Echinococcus granulosus alpha 1A adrenergic receptor 0.054 0.1548 0.1544
Schistosoma mansoni DNA polymerase eta 0.0019 0.0014 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.054 0.1548 0.1544
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1829 0.5338 0.5336
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0014 0.0076
Toxoplasma gondii hypothetical protein 0.0067 0.0156 0.0228
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0028 0.004 0.0271
Echinococcus multilocularis orexin receptor type 2 0.054 0.1548 0.1544
Echinococcus multilocularis musashi 0.0027 0.0037 0.0033
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0013 0.0013
Trypanosoma brucei unspecified product 0.0019 0.0014 0.0027
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0013 0.0029
Loa Loa (eye worm) acetyltransferase 0.0141 0.0373 0.0373
Loa Loa (eye worm) RNA binding protein 0.0076 0.0182 0.0182
Brugia malayi hypothetical protein 0.054 0.1548 0.1548
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0171 0.0596
Trypanosoma cruzi hypothetical protein, conserved 0.0448 0.1277 0.3316
Loa Loa (eye worm) hypothetical protein 0.0448 0.1277 0.1277
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0132 0.0128
Echinococcus granulosus single minded 2 0.0036 0.0064 0.006
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0382 0.0382
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0013 0.0029
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.3413 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0067 0.0164
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0448 0.1277 0.1274
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.027 0.0694
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0013 0.0009
Plasmodium falciparum chitinase 0.0033 0.0053 0.0389
Mycobacterium ulcerans hypothetical protein 0.0073 0.0171 0.3136
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.1183 0.344 0.3437
Giardia lamblia Kinase, PLK 0.0094 0.0234 0.0338
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0063 0.0154
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0014 0.0027
Echinococcus granulosus biogenic amine 5HT receptor 0.054 0.1548 0.1544
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0122 0.0315 0.0467
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.054 0.1548 0.1544
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0187 0.1442
Leishmania major cytochrome p450-like protein 0.0054 0.0116 0.0293
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.054 0.1548 0.1544
Loa Loa (eye worm) adenylyl cyclase 3 0.0183 0.0496 0.0496
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0013 0.0009
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0001
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0024 0.0052
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Echinococcus granulosus hypothetical protein 0.054 0.1548 0.1544
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.003 0.0091
Trichomonas vaginalis importin beta-1, putative 0.0025 0.003 0.0091
Brugia malayi Serotonin receptor 0.054 0.1548 0.1548
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0448 0.1277 0.4558
Onchocerca volvulus 0.054 0.1548 0.5474
Echinococcus granulosus tar DNA binding protein 0.0076 0.0182 0.0179
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0182 0.0179
Schistosoma mansoni DNA helicase recq5 0.0018 0.0009 0.0005
Echinococcus granulosus orexin receptor type 2 0.054 0.1548 0.1544
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.054 0.1548 0.1544
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0095 0.0324
Schistosoma mansoni adenoreceptor 0.054 0.1548 0.1544
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0067 0.0164
Brugia malayi hypoxia-induced factor 1 0.0151 0.0402 0.0402
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0996 0.2887 0.2887
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0028 0.004 0.0515
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0105 0.0262
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0035
Brugia malayi Glycosyl hydrolases family 18 protein 0.0033 0.0053 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.054 0.1548 0.1544
Brugia malayi endochitinase 0.0222 0.0609 0.0609
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0171 0.0167
Onchocerca volvulus 0.054 0.1548 0.5474
Echinococcus multilocularis bloom syndrome protein 0.0042 0.0082 0.0078
Schistosoma mansoni biogenic amine (dopamine) receptor 0.054 0.1548 0.1544
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0042 0.0099
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0009 0.0009
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0028 0.004 0.0515
Brugia malayi sulfakinin receptor protein 0.054 0.1548 0.1548
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0004 0.0001
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0028 0.004 0.0515
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0105 0.0101
Trypanosoma brucei hypothetical protein, conserved 0.0448 0.1277 0.3316
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0448 0.1277 0.1274
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0448 0.1277 0.1274
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0171 0.3136
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0448 0.1277 0.1274
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0584 0.1676 0.4356
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0013
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0187 0.0276
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0028 0.004 0.0271
Plasmodium falciparum importin beta, putative 0.003 0.0047 0.0336
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Echinococcus multilocularis g protein coupled receptor 0.054 0.1548 0.1544
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.054 0.1548 0.1544
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0382 0.0382
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0018 0.0009 0.0005
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0448 0.1277 0.4558
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0105 0.0359
Schistosoma mansoni hypothetical protein 0.0839 0.2427 0.2424
Schistosoma mansoni neuropeptide receptor 0.054 0.1548 0.1544
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0584 0.1676 0.4356
Giardia lamblia Hypothetical protein 0.0448 0.1277 0.1907
Onchocerca volvulus 0.0073 0.0171 0.0485
Echinococcus multilocularis rhodopsin orphan GPCR 0.054 0.1548 0.1544
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0111 0.028
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0123 0.0309
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0448 0.1277 0.4558
Loa Loa (eye worm) chitinase I 0.0222 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0516 0.1475 0.5268
Echinococcus granulosus intermediate filament protein 0.0027 0.0037 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.054 0.1548 0.1544
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0493 0.0489
Schistosoma mansoni biogenic amine (5HT) receptor 0.054 0.1548 0.1544
Schistosoma mansoni ran 0.0022 0.0023 0.0019
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0338 0.0952 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0018 0.0009 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0004
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.054 0.1548 0.1544
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0182 0.0182
Toxoplasma gondii exonuclease III APE 0.0037 0.0067 0.0095
Echinococcus granulosus adenylate cyclase type IX 0.0109 0.0278 0.0274
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0013 0.0009
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0042 0.5
Schistosoma mansoni ap endonuclease 0.0037 0.0067 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0015 0.0011
Echinococcus multilocularis fmrfamide receptor 0.054 0.1548 0.1544
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0014 0.0018
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0135
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0171 0.1264
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0052 0.0293
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0171 0.1264
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0105 0.0359
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0024 0.007
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.054 0.1548 0.1548
Echinococcus granulosus rhodopsin orphan GPCR 0.054 0.1548 0.1544
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0156 0.0542
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0028 0.004 0.0271
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0023 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.054 0.1548 0.1544
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.005
Mycobacterium tuberculosis Possible chitinase 0.0189 0.0513 0.3866
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0659 0.1896 0.6773
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.0082 0.0082
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0061 0.0057
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.054 0.1548 0.1544
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0037 0.0037
Loa Loa (eye worm) microfilarial chitinase 0.0189 0.0513 0.0513
Leishmania major cytochrome p450-like protein 0.0028 0.004 0.0094
Brugia malayi phosphofructokinase 0.0106 0.027 0.027
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.091 0.091
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0105 0.0262
Echinococcus multilocularis g protein coupled receptor 0.054 0.1548 0.1544
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0013 0.0009
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0064 0.0988
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0014 0.001
Brugia malayi PAS domain containing protein 0.0049 0.0101 0.0101
Schistosoma mansoni alpha-1 adrenergic receptor 0.054 0.1548 0.1544
Onchocerca volvulus Neuropeptide F receptor homolog 0.054 0.1548 0.5474
Brugia malayi endochitinase 0.0222 0.0609 0.0609
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0448 0.1277 0.4558
Brugia malayi beta-lactamase family protein 0.0073 0.0171 0.0171
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0105 0.0101
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0234 0.0821
Echinococcus multilocularis rhodopsin orphan GPCR 0.054 0.1548 0.1544
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0014 0.001
Plasmodium vivax chitinase 0.0033 0.0053 0.0129
Schistosoma mansoni blooms syndrome DNA helicase 0.0033 0.0056 0.0052
Echinococcus multilocularis geminin 0.0839 0.2427 0.2424
Echinococcus multilocularis tachykinin peptides receptor 99D 0.054 0.1548 0.1544
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0516 0.1475 0.1475
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0042 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0171 0.0435
Echinococcus granulosus rhodopsin orphan GPCR 0.054 0.1548 0.1544
Brugia malayi Dopamine receptor 0.054 0.1548 0.1548
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0023 0.005
Echinococcus granulosus g protein coupled receptor 0.054 0.1548 0.1544
Toxoplasma gondii ABC1 family protein 0.0073 0.0171 0.0251
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0042 0.005
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0075 0.0177 0.0451
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.1321 0.3843 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0014 0.001
Loa Loa (eye worm) neuropeptide F receptor 0.054 0.1548 0.1548
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0028 0.004 0.0515
Echinococcus multilocularis serotonin receptor 0.054 0.1548 0.1544
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0067 0.0164
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0171 0.0596
Schistosoma mansoni ran 0.0022 0.0023 0.0019
Schistosoma mansoni hypothetical protein 0.0839 0.2427 0.2424
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0004 0.0003
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.054 0.1548 0.1548
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0028 0.004 0.0271
Brugia malayi RE15519p 0.054 0.1548 0.1548
Brugia malayi hypothetical protein 0.0019 0.0013 0.0013
Leishmania major hypothetical protein, conserved 0.0078 0.0187 0.0478
Onchocerca volvulus 0.0122 0.0315 0.1008
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0234 0.0821
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0382 0.0986
Onchocerca volvulus 0.054 0.1548 0.5474
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0493 0.0489
Echinococcus granulosus cytochrome P450 2K1 0.0028 0.004 0.0036
Brugia malayi MAP kinase sur-1 0.005 0.0105 0.0105
Echinococcus granulosus tm gpcr rhodopsin 0.054 0.1548 0.1544
Brugia malayi hypothetical protein 0.054 0.1548 0.1548
Onchocerca volvulus 0.054 0.1548 0.5474
Schistosoma mansoni chitinase 0.0033 0.0053 0.005
Schistosoma mansoni biogenic amine (5HT) receptor 0.054 0.1548 0.1544
Plasmodium vivax SET domain protein, putative 0.0122 0.0315 0.0811
Schistosoma mansoni DNA helicase recq1 0.0018 0.0009 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0067 0.0164
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.027 0.2021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0244 0.0244
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0171 0.0435
Echinococcus multilocularis neuropeptides capa receptor 0.054 0.1548 0.1544
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.054 0.1548 0.1544
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0015 0.0015
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0516 0.1475 0.1472
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0123 0.0119
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0448 0.1277 0.1274
Brugia malayi hypothetical protein 0.054 0.1548 0.1548
Echinococcus granulosus neuropeptide FF receptor 2 0.054 0.1548 0.1544
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.054 0.1548 0.1544
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0116 0.0116
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0028 0.004 0.0271
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0013 0.0009
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0123 0.0119
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0171 0.0596
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0584 0.1676 0.5987
Trypanosoma cruzi cytochrome P450, putative 0.0054 0.0116 0.0293
Trypanosoma cruzi cytochrome P450, putative 0.0054 0.0116 0.0293
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0105 0.0262
Schistosoma mansoni hypothetical protein 0.054 0.1548 0.1544
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.027 0.0953
Echinococcus multilocularis snurportin 1 0.0324 0.091 0.0907
Trichomonas vaginalis esterase, putative 0.0073 0.0171 0.0596
Schistosoma mansoni biogenic amine receptor 0.054 0.1548 0.1544
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0028 0.004 0.0094
Echinococcus granulosus dna polymerase kappa 0.0019 0.0014 0.001
Schistosoma mansoni kinase 0.0048 0.0098 0.0095
Brugia malayi hypothetical protein 0.054 0.1548 0.1548
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Brugia malayi Cytochrome P450 family protein 0.0054 0.0116 0.0116
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0018 0.0009 0.0009
Leishmania major chitinase 0.0222 0.0609 0.1577
Echinococcus granulosus serotonin receptor 0.054 0.1548 0.1544
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.1321 0.3843 1
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0171 0.3243
Trypanosoma brucei cytochrome P450, putative 0.0054 0.0116 0.0293
Loa Loa (eye worm) G-protein coupled receptor 0.054 0.1548 0.1548
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0373 0.0369
Echinococcus multilocularis dna polymerase eta 0.0019 0.0014 0.001
Brugia malayi MH2 domain containing protein 0.0144 0.0382 0.0382
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0028 0.004 0.0271
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0028 0.004 0.0515
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0067 0.0578
Trichomonas vaginalis conserved hypothetical protein 0.0448 0.1277 0.4558
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0013 0.0009
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.008 0.0114
Leishmania major importin beta-1 subunit, putative 0.0025 0.003 0.0067
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0234 0.2353
Onchocerca volvulus Putative endochitinase 0.0033 0.0053 0.006
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0448 0.1277 0.1277
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0448 0.1277 0.1911
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.1321 0.3843 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0028 0.004 0.0271
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0075 0.0177 0.0451
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0014 0.0027
Echinococcus granulosus tm gpcr rhodopsin 0.054 0.1548 0.1544
Echinococcus granulosus rhodopsin orphan GPCR 0.054 0.1548 0.1544
Toxoplasma gondii hypothetical protein 0.0067 0.0156 0.0228
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0009 0.0007
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0054 0.0116 0.2046
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0448 0.1277 0.1274
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0014 0.001
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0067 0.0153 0.0153
Echinococcus granulosus neuropeptide receptor 0.054 0.1548 0.1544
Mycobacterium tuberculosis Conserved protein 0.0073 0.0171 0.1264
Schistosoma mansoni hypothetical protein 0.0067 0.0153 0.015
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0101 0.0097
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.027 0.0694
Brugia malayi neuropeptide F receptor 0.054 0.1548 0.1548
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0013 0.0029
Onchocerca volvulus 0.0074 0.0176 0.0502
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0187 0.0478
Echinococcus granulosus G protein coupled receptor 139 0.054 0.1548 0.1544
Brugia malayi Cytochrome P450 family protein 0.0028 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0073 0.0171 0.0171
Giardia lamblia hypothetical protein 0.0448 0.1277 0.1907
Echinococcus granulosus tm gpcr rhodopsin 0.054 0.1548 0.1544
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0234 0.0598
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.054 0.1548 0.1544
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0037 0.0037
Brugia malayi intermediate filament protein 0.0027 0.0037 0.0037
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0013 0.0009
Leishmania major GTP-binding protein, putative 0.0022 0.0023 0.005
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0004 0.0004
Echinococcus multilocularis G-protein coupled receptor, putative 0.054 0.1548 0.1544
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0156 0.0396
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0234 0.023
Schistosoma mansoni hypothetical protein 0.0031 0.0048 0.0044
Echinococcus multilocularis neuropeptide Y receptor 0.054 0.1548 0.1544
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.004 0.0094
Leishmania major cytochrome p450-like protein 0.0028 0.004 0.0094
Onchocerca volvulus 0.0036 0.0064 0.0097
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0042 0.0299
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0013 0.0009
Echinococcus granulosus dro:myosuppressin receptor 0.054 0.1548 0.1544
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0171 0.1264
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0013 0.0029
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0516 0.1475 0.5268
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.027 0.0694
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0171 0.0435
Echinococcus multilocularis adenylate cyclase type IX 0.0109 0.0278 0.0274
Schistosoma mansoni biogenic amine receptor 0.054 0.1548 0.1544
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0042 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0053 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.027 0.0953
Loa Loa (eye worm) CYP4Cod1 0.0054 0.0116 0.0116
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0067 0.0164
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0028 0.004 0.0515
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.008 0.0114
Loa Loa (eye worm) TYRA-2 protein 0.054 0.1548 0.1548
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.004 0.0094
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2433 0.7116 0.7115
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.043 0.3234
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.027 0.0267
Brugia malayi Endochitinase 0.0222 0.0609 0.0609
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0448 0.1277 0.1911
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0123 0.0898
Trypanosoma cruzi hypothetical protein, conserved 0.0448 0.1277 0.3316
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.027 0.5713
Schistosoma mansoni hypothetical protein 0.054 0.1548 0.1544
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.027 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Schistosoma mansoni opsin-like receptor 0.054 0.1548 0.1544
Brugia malayi 6-phosphofructokinase 0.0106 0.027 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0013 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0077 0.0185 0.0185
Onchocerca volvulus Putative endochitinase 0.0222 0.0609 0.2075
Echinococcus multilocularis serotonin receptor 0.054 0.1548 0.1544
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0028 0.004 0.0271
Schistosoma mansoni amine GPCR 0.054 0.1548 0.1544
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.0855 0.2217
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0123 0.217
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0014 0.0076
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0069 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0448 0.1277 0.3316
Echinococcus granulosus neuropeptide Y receptor 0.054 0.1548 0.1544
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Toxoplasma gondii cytochrome p450 superfamily protein 0.0028 0.004 0.0054
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1321 0.3843 0.5764
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0047 0.0111
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0517 0.1478 0.5277
Loa Loa (eye worm) neuropeptide F receptor 0.054 0.1548 0.1548
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0063 0.0154
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0584 0.1676 0.5987
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0451 0.1284 0.1922
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0097 0.0097
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0013 0.0013
Echinococcus granulosus neuropeptides capa receptor 0.054 0.1548 0.1544
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0584 0.1676 0.5987
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0014 0.0036
Brugia malayi Dopamine receptor protein 2 0.054 0.1548 0.1548
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Loa Loa (eye worm) hypothetical protein 0.0073 0.0171 0.0171
Trypanosoma brucei polo-like protein kinase 0.0094 0.0234 0.0598
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.054 0.1548 0.1544
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.054 0.1548 0.1544
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0171 0.0171
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0013 0.0013
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0105 0.0262
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0013 0.0009
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0013 0.0013
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.0082 0.0278
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.054 0.1548 0.1544
Brugia malayi hypothetical protein 0.0119 0.0308 0.0308
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0171 0.3136
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0171 0.0596
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.054 0.1548 0.1544
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.027 0.027
Echinococcus multilocularis alpha 1A adrenergic receptor 0.054 0.1548 0.1544
Loa Loa (eye worm) hypothetical protein 0.0073 0.0171 0.0171
Echinococcus multilocularis dro:myosuppressin receptor 0.054 0.1548 0.1544
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0028 0.004 0.0271
Trypanosoma brucei protein kinase, putative 0.005 0.0105 0.0262
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0234 0.0598
Echinococcus granulosus histone lysine methyltransferase setb 0.0122 0.0315 0.0311
Brugia malayi 6-phosphofructokinase 0.0106 0.027 0.027
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0084 0.0208
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0064 0.006
Echinococcus granulosus neuropeptide receptor A26 0.054 0.1548 0.1544
Schistosoma mansoni biogenic amine (dopamine) receptor 0.054 0.1548 0.1544
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0448 0.1277 0.1911
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.0493 0.0489
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0053 0.0435
Brugia malayi beta-lactamase 0.0073 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Plasmodium vivax importin-beta 2, putative 0.003 0.0047 0.0111
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0362 0.0358
Onchocerca volvulus 0.054 0.1548 0.5474
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.0855 0.2217
Brugia malayi isocitrate dehydrogenase 0.0016 0.0004 0.0004
Brugia malayi hypothetical protein 0.005 0.0106 0.0106
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0037 0.0065 0.0061
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0448 0.1277 0.1277
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0067 0.0475
Echinococcus multilocularis sodium channel protein 0.0037 0.0065 0.0061
Brugia malayi follicle stimulating hormone receptor 0.0996 0.2887 0.2887
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0952 0.3395
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0067 0.0274
Leishmania major hypothetical protein, conserved 0.0073 0.0171 0.0435
Onchocerca volvulus 0.054 0.1548 0.5474
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0028 0.004 0.0515
Brugia malayi jmjC domain containing protein 0.0059 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0311 0.0871 0.0871
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0142 0.0375 0.2817
Leishmania major DNA polymerase kappa, putative 0.0019 0.0014 0.0027
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0135
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0013 0.0009
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.054 0.1548 0.1544
Brugia malayi hypothetical protein 0.0019 0.0013 0.0013
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0063 0.0059
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0028 0.004 0.0271
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0182 0.0179
Echinococcus multilocularis rhodopsin orphan GPCR 0.054 0.1548 0.1544
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0009 0.0009
Brugia malayi beta-lactamase family protein 0.0073 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0028 0.004 0.0271
Echinococcus granulosus sex peptide receptor 0.054 0.1548 0.1544
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.1321 0.3843 0.3841
Brugia malayi Dopamine receptor protein 1 0.054 0.1548 0.1548
Onchocerca volvulus Putative endochitinase 0.0222 0.0609 0.2075
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0013 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.054 0.1548 0.1544
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0315 0.0311
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0448 0.1277 0.3316
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0448 0.1277 0.1911
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0517 0.1478 0.3839
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0448 0.1277 1
Schistosoma mansoni single-minded 0.0049 0.0101 0.0097
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.054 0.1548 0.1544
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0448 0.1277 0.1911
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0028 0.004 0.0515
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0031 0.0048 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0182 0.0179
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0028 0.004 0.0515
Echinococcus granulosus neuropeptides capa receptor 0.054 0.1548 0.1544
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0182 0.0182
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0024 0.0122
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.027 0.0267
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0028 0.004 0.0094
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0234 0.0234
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0132 0.0128
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0028 0.004 0.0271
Mycobacterium ulcerans PE-PGRS family protein 0.0033 0.0053 0.0783
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.027 0.2744
Brugia malayi Glycosyl hydrolases family 18 protein 0.0033 0.0053 0.0053
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0015 0.0011
Plasmodium vivax phosphodiesterase gamma, putative 0.0448 0.1277 0.3316
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0105 0.0262
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0448 0.1277 0.1911
Toxoplasma gondii hypothetical protein 0.0136 0.0357 0.0529
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.054 0.1548 0.1548
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.0357 0.1261
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.054 0.1548 0.5474
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0659 0.1896 0.6773
Trichomonas vaginalis set domain proteins, putative 0.0965 0.2796 1
Brugia malayi G protein-coupled receptor 0.054 0.1548 0.1548
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0063 0.021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.054 0.1548 0.1544
Echinococcus multilocularis neuropeptide s receptor 0.054 0.1548 0.1544
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0123 0.217
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0338 0.0952 1
Echinococcus granulosus rhodopsin orphan GPCR 0.054 0.1548 0.1544
Plasmodium falciparum phosphodiesterase delta, putative 0.0448 0.1277 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.054 0.1548 0.1548
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0052 0.0361
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0067 0.0156 0.115
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0132 0.0128
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 0.0952 0.3395
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0584 0.1676 0.5987
Trypanosoma cruzi hypothetical protein, conserved 0.0448 0.1277 0.3316
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0584 0.1676 0.4356
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.054 0.1548 0.1544
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.054 0.1548 0.1544
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0448 0.1277 0.3316
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0517 0.1478 0.5277
Brugia malayi larval opioid receptor 0.054 0.1548 0.1548
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0187 0.1442
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0095 0.0324
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1829 0.5338 0.5336
Trichomonas vaginalis conserved hypothetical protein 0.0659 0.1896 0.6773
Brugia malayi GnHR receptor homolog 0.054 0.1548 0.1548
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.1321 0.3843 1
Loa Loa (eye worm) G-protein coupled receptor 0.054 0.1548 0.1548
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0111 0.0111
Leishmania major DNA polymerase eta, putative 0.0019 0.0014 0.0027
Echinococcus multilocularis g-protein coupled receptor 0.054 0.1548 0.1544
Schistosoma mansoni amine GPCR 0.054 0.1548 0.1544
Brugia malayi hypothetical protein 0.0033 0.0053 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.027 0.0953
Echinococcus granulosus neuropeptide receptor 0.054 0.1548 0.1544
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.0493 0.0489
Schistosoma mansoni opsin-like receptor 0.054 0.1548 0.1544
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0448 0.1277 0.1911
Brugia malayi Tachykinin-like peptides receptor 99D 0.054 0.1548 0.1548
Echinococcus granulosus geminin 0.0839 0.2427 0.2424
Echinococcus multilocularis g protein coupled receptor 0.054 0.1548 0.1544
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0009 0.0007
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0063 0.0059
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Echinococcus multilocularis rhodopsin orphan GPCR 0.054 0.1548 0.1544
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0078 0.0187 0.0187
Schistosoma mansoni opsin-like receptor 0.054 0.1548 0.1544
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0182 0.0179
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0028 0.004 0.0271
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0042 0.0135
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0014 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0004
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2277 0.6657 0.6656
Brugia malayi ORL1-like opioid receptor 0.054 0.1548 0.1548
Brugia malayi neuropeptide F receptor 0.054 0.1548 0.1548
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0018 0.0009 0.0005
Mycobacterium ulcerans chitinase/cellulase 0.0189 0.0513 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0061 0.0057
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0448 0.1277 0.1911
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.008 0.027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0448 0.1277 0.1911
Schistosoma mansoni neuropeptide receptor 0.054 0.1548 0.1544
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0013 0.0013
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.1321 0.3843 1
Brugia malayi Endochitinase 0.0033 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0028 0.004 0.0036
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0014 0.0027
Echinococcus multilocularis fmrfamide receptor 0.054 0.1548 0.1544
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0234 0.023
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0042 0.0313
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0658 0.1894 0.4924
Echinococcus multilocularis 0.0028 0.004 0.0036
Echinococcus granulosus tachykinin peptides receptor 99D 0.054 0.1548 0.1544
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0584 0.1676 0.5987
Brugia malayi hypothetical protein 0.0078 0.0187 0.0187
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0014 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.054 0.1548 0.1544
Onchocerca volvulus 0.0073 0.0171 0.0485
Brugia malayi Cytochrome P450 family protein 0.0047 0.0097 0.0097
Echinococcus granulosus Glycoside hydrolase chitinase domain containing protein 1 0.0033 0.0053 0.005
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0013 0.0009
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.2277 0.6657 0.6656
Echinococcus multilocularis lamin dm0 0.0027 0.0037 0.0033
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0024 0.0052
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0084 0.0208
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0014 0.0027
Loa Loa (eye worm) hypothetical protein 0.054 0.1548 0.1548
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0048 0.0044
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0028 0.004 0.0271

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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