Detailed information for compound 847445

Basic information

Technical information
  • TDR Targets ID: 847445
  • Name: N'-(3-chlorobenzoyl)furan-2-carbohydrazide
  • MW: 264.664 | Formula: C12H9ClN2O3
  • H donors: 2 H acceptors: 2 LogP: 2.39 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)C(=O)NNC(=O)c1ccco1
  • InChi: 1S/C12H9ClN2O3/c13-9-4-1-3-8(7-9)11(16)14-15-12(17)10-5-2-6-18-10/h1-7H,(H,14,16)(H,15,17)
  • InChiKey: ANJDUBHNTLZEEY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-[(3-chlorophenyl)-oxomethyl]-2-furancarbohydrazide
  • N'-(3-chlorophenyl)carbonylfuran-2-carbohydrazide
  • ZINC00299701
  • BIM-0018309.P001
  • CBMicro_018531

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.1579 0.2868
Onchocerca volvulus Bile acid receptor homolog 0.008 0.0628 0.1633
Brugia malayi glutaminase DH11.1 0.0327 0.2755 0.4993
Entamoeba histolytica acyl-coA synthetase, putative 0.003 0.0199 0.1234
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.01 0.0509
Mycobacterium tuberculosis Conserved protein 0.0034 0.0238 0.1265
Brugia malayi conserved hypotetical protein 0.0038 0.0265 0.0461
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.008 0.0628 0.1179
Schistosoma mansoni hypothetical protein 0.0331 0.2789 0.524
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.01 0.0313
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.0012 0.0021
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0265 0.0265
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0123 0.0639
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0012 0.0049 0.0068
Trypanosoma brucei importin beta-1 subunit, putative 0.0018 0.0098 0.0266
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.01 0.0509
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0008 0.0012 0.0022
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0143 0.1176 0.7666
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.01 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-25 0.008 0.0628 0.1121
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.008 0.0628 0.0628
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.02 0.1662 0.3003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.003 0.0199 0.0199
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0049 0.0146
Brugia malayi vesicular acetylcholine transporter unc-17 0.0446 0.3784 0.6865
Trichomonas vaginalis sucrase-isomaltase, putative 0.0143 0.1176 0.4245
Echinococcus multilocularis 0.0018 0.01 0.01
Trypanosoma brucei glycosyl hydrolase-like protein 0.0053 0.0401 0.126
Loa Loa (eye worm) hypothetical protein 0.0022 0.0134 0.0223
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.003 0.0199 0.034
Trichomonas vaginalis alpha-glucosidase, putative 0.0053 0.0401 0.142
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.008 0.0628 0.1179
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.003 0.0199 0.1052
Leishmania major importin beta-1 subunit, putative 0.0015 0.0068 0.0211
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.01 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-1 0.008 0.0628 0.1121
Echinococcus granulosus tumor protein p63 0.0383 0.3239 0.5881
Echinococcus granulosus vesicular acetylcholine transporter 0.0446 0.3784 0.6871
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0053 0.0401 0.1298
Brugia malayi N-terminal motif family protein 0.0137 0.1123 0.2023
Onchocerca volvulus 0.0009 0.0017 0.0014
Entamoeba histolytica acyl-CoA synthetase, putative 0.003 0.0199 0.1234
Trichomonas vaginalis ap endonuclease, putative 0.003 0.0199 0.0682
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.01 0.0509
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0238 0.0447
Schistosoma mansoni nuclear hormone receptor 0.008 0.0628 0.1179
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0185 0.1531 0.5538
Brugia malayi nuclear hormone receptor 0.0038 0.0265 0.0461
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.0265 0.0461
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0424 0.0796
Leishmania major 4-coumarate:coa ligase-like protein 0.003 0.0199 0.0638
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.008 0.0628 0.0628
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.01 0.0509
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0012 0.0049 0.0146
Leishmania major alpha glucosidase II subunit, putative 0.0143 0.1176 0.3829
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.01 0.0509
Echinococcus granulosus cpg binding protein 0.0025 0.0153 0.0277
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0053 0.0401 0.142
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0185 0.1531 0.5538
Trichomonas vaginalis importin beta-1, putative 0.0015 0.0068 0.0207
Brugia malayi tailless protein 0.0038 0.0265 0.0461
Trypanosoma brucei hypothetical protein, conserved 0.0034 0.0238 0.0725
Schistosoma mansoni nuclear receptor 0.0038 0.0265 0.0498
Onchocerca volvulus 0.003 0.0199 0.0497
Schistosoma mansoni zinc finger protein 0.0038 0.0265 0.0498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1579 0.2967
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0091 0.0726 0.393
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0238 0.0826
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.01 0.0509
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.01 0.0509
Echinococcus granulosus GTP binding nuclear protein Ran 0.0013 0.0057 0.0103
Loa Loa (eye worm) hypothetical protein 0.003 0.0199 0.0341
Leishmania major 4-coumarate:coa ligase-like protein 0.003 0.0199 0.0638
Loa Loa (eye worm) hypothetical protein 0.0034 0.0238 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-25 0.008 0.0628 0.1121
Brugia malayi hypothetical protein 0.0042 0.0304 0.0532
Schistosoma mansoni RAR-like nuclear receptor 0.008 0.0628 0.1179
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.003 0.0199 0.0665
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0265 0.0265
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0265 0.0498
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0012 0.0022
Treponema pallidum exodeoxyribonuclease (exoA) 0.003 0.0199 0.1012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0134 0.0223
Plasmodium vivax acyl-CoA synthetase, putative 0.0022 0.0134 0.5003
Brugia malayi Glycosyl hydrolases family 31 protein 0.0647 0.5507 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0628 0.1121
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.01 0.0302
Echinococcus granulosus intermediate filament protein 0.0027 0.0174 0.0316
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0017 0.0057
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0137 0.1123 0.2946
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0038 0.0265 0.0265
Plasmodium falciparum glutathione reductase 0.0012 0.0049 0.1349
Leishmania major trypanothione reductase 0.0036 0.0251 0.0807
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0143 0.1176 0.2119
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.01 0.0302
Entamoeba histolytica acyl-CoA synthetase, putative 0.003 0.0199 0.1234
Loa Loa (eye worm) hypothetical protein 0.0013 0.0054 0.0076
Onchocerca volvulus 0.0027 0.0174 0.043
Mycobacterium tuberculosis Probable dehydrogenase 0.0082 0.0647 0.3499
Schistosoma mansoni lamin 0.0027 0.0174 0.0327
Trichomonas vaginalis maltase-glucoamylase, putative 0.0053 0.0401 0.142
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0036 0.0251 0.1334
Schistosoma mansoni thyroid hormone receptor 0.008 0.0628 0.1179
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.0012 0.0022
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0178 0.0324
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0009 0.0017 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.01 0.0509
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0009 0.0017 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0542 0.0964
Loa Loa (eye worm) hypothetical protein 0.0042 0.0304 0.0532
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0008 0.0012 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-14 0.008 0.0628 0.1121
Schistosoma mansoni cpg binding protein 0.0025 0.0153 0.0287
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0461
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0185 0.1531 0.5538
Mycobacterium ulcerans lipase LipD 0.0034 0.0238 0.0808
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0265 0.0481
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0049 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0049 0.0146
Onchocerca volvulus 0.0056 0.0424 0.1093
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.008 0.0628 0.1121
Trichomonas vaginalis alpha-glucosidase, putative 0.0143 0.1176 0.4245
Toxoplasma gondii histone lysine methyltransferase SET1 0.0045 0.0329 0.2693
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.003 0.0199 0.0665
Onchocerca volvulus 0.008 0.0628 0.1633
Loa Loa (eye worm) hypothetical protein 0.0034 0.0238 0.0412
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.008 0.0628 0.1121
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0012 0.0049 0.0103
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0628 0.0628
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0185 0.1531 0.5538
Mycobacterium leprae conserved hypothetical protein 0.0034 0.0238 0.3118
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0012 0.0049 0.0272
Echinococcus granulosus neutral alpha glucosidase AB 0.0143 0.1176 0.2136
Plasmodium vivax importin-beta 2, putative 0.0018 0.0098 0.3469
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0013 0.0057 0.0082
Echinococcus granulosus lamin dm0 0.0027 0.0174 0.0316
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.01 0.0713
Leishmania major 4-coumarate:coa ligase-like protein 0.003 0.0199 0.0638
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0009 0.0017 0.0043
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.0012 0.0021
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.0012 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.1176 0.3829
Brugia malayi beta-lactamase family protein 0.0034 0.0238 0.0413
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.009 0.0718 0.9883
Echinococcus multilocularis snurportin 1 0.0195 0.1616 0.1616
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.01 0.0509
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0049 0.0146
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0265 0.0498
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.008 0.0628 0.0628
Onchocerca volvulus 0.0095 0.0763 0.1992
Loa Loa (eye worm) glutaminase 2 0.0327 0.2755 0.4992
Loa Loa (eye worm) hypothetical protein 0.008 0.0628 0.1121
Schistosoma mansoni ap endonuclease 0.003 0.0199 0.0373
Brugia malayi Cytochrome P450 family protein 0.0025 0.0158 0.0267
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0185 0.1531 0.5538
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0082 0.0647 0.3499
Brugia malayi hypothetical protein 0.0038 0.0265 0.0461
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0009 0.0017 0.0057
Schistosoma mansoni steroid hormone receptor ad4bp 0.008 0.0628 0.1179
Brugia malayi Nuclear hormone receptor family member nhr-19 0.008 0.0628 0.1121
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0042 0.0304 0.0552
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0265 0.0481
Brugia malayi AMP-binding enzyme family protein 0.003 0.0199 0.0342
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0265 0.0461
Trypanosoma cruzi importin beta-1 subunit, putative 0.0015 0.0068 0.0211
Schistosoma mansoni acetyl-CoA synthetase 0.0009 0.0017 0.0032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0339 0.1175
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0158 0.0504
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0265 0.0481
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0265 0.0265
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.0012 0.0022
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0143 0.1176 0.4245
Leishmania major cytochrome p450-like protein 0.0018 0.01 0.0313
Echinococcus multilocularis lysosomal alpha glucosidase 0.0647 0.5507 0.5507
Onchocerca volvulus 0.0009 0.0017 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0192 0.036
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0034 0.0238 0.1265
Onchocerca volvulus 0.0034 0.0238 0.06
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.0012 0.0022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0068 0.0207
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0022 0.0134 0.0427
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0017 0.001
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0339 0.0637
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0461
Loa Loa (eye worm) hypothetical protein 0.0056 0.0424 0.075
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0013 0.0057 0.1698
Trichomonas vaginalis alpha-glucosidase, putative 0.0053 0.0401 0.142
Schistosoma mansoni ran 0.0013 0.0057 0.0107
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0143 0.1176 0.4245
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0265 0.0461
Echinococcus multilocularis FTZ F1 alpha 0.008 0.0628 0.0628
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.008 0.0628 0.1179
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0049 0.0146
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.0265 0.0498
Schistosoma mansoni mixed-lineage leukemia protein mll 0.005 0.0374 0.0704
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0158 0.0463
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0034 0.0238 0.0447
Trichomonas vaginalis ap endonuclease, putative 0.003 0.0199 0.0682
Loa Loa (eye worm) hypothetical protein 0.003 0.0199 0.0341
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0049 0.0146
Trichomonas vaginalis antibiotic synthetase, putative 0.0009 0.0017 0.002
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0265 0.0265
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.003 0.0199 0.0636
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.01 0.0302
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0363 0.3066 0.5559
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0017 0.001
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0158 0.0504
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0049 0.0146
Loa Loa (eye worm) hypothetical protein 0.0022 0.0134 0.0223
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0091 0.0726 0.393
Mycobacterium ulcerans esterase/lipase LipP 0.0034 0.0238 0.0808
Onchocerca volvulus 0.0227 0.1899 0.5002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0013 0.0057 0.0173
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.1579 0.2853
Loa Loa (eye worm) hypothetical protein 0.0034 0.0238 0.0412
Schistosoma mansoni alpha-glucosidase 0.0557 0.4732 0.8891
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.01 0.0509
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.008 0.0628 0.1121
Loa Loa (eye worm) cytochrome P450 0.0018 0.01 0.016
Brugia malayi hypothetical protein 0.0038 0.0265 0.0461
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.003 0.0199 0.7768
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0192 0.0192
Schistosoma mansoni glutaminase 0.0327 0.2755 0.5177
Onchocerca volvulus 0.0034 0.0238 0.06
Echinococcus granulosus beta LACTamase domain containing family member 0.0034 0.0238 0.0432
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0461
Schistosoma mansoni hypothetical protein 0.0625 0.5322 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0123 0.0639
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0192 0.036
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0046 0.0339 0.1094
Schistosoma mansoni hypothetical protein 0.0625 0.5322 1
Mycobacterium leprae putative cytochrome p450 0.0018 0.01 0.1165
Mycobacterium tuberculosis Probable esterase LipL 0.0034 0.0238 0.1265
Trichomonas vaginalis alpha-glucosidase, putative 0.0053 0.0401 0.142
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0265 0.0461
Entamoeba histolytica hypothetical protein 0.0015 0.0068 0.0374
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.01 0.0302
Echinococcus granulosus geminin 0.0625 0.5322 0.9665
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.008 0.0628 0.0628
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0017 0.0043
Trichomonas vaginalis alpha-glucosidase, putative 0.0143 0.1176 0.4245
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0461
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0304 0.0532
Brugia malayi Glycosyl hydrolases family 31 protein 0.0053 0.0401 0.0709
Onchocerca volvulus 0.0009 0.0017 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.01 0.0509
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0461
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0265 0.0672
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0174 0.0295
Brugia malayi photoreceptor-specific nuclear receptor 0.008 0.0628 0.1121
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.0012 0.0022
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0042 0.0304 0.0532
Mycobacterium ulcerans glutaminase 0.0327 0.2755 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0628 0.114
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0012 0.0049 0.0115
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0192 0.1508
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0185 0.1531 0.5538
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0009 0.0017 0.0057
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0009 0.0017 0.0043
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0049 0.0146
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.008 0.0628 0.1633
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.003 0.0199 0.0596
Trichomonas vaginalis glutaminase, putative 0.0327 0.2755 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.008 0.0628 0.114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1579 0.2967
Echinococcus granulosus expressed protein 0.0008 0.0012 0.0021
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0009 0.0017 0.0057
Schistosoma mansoni vesicular acetylcholine transporter 0.0446 0.3784 0.711
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0339 0.1175
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.01 0.0509
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0082 0.0647 0.3499
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0012 0.0022
Echinococcus multilocularis lamin 0.0027 0.0174 0.0174
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0012 0.0022
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.01 0.0313
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0123 0.0639
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0192 0.036
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0199 0.0665
Mycobacterium tuberculosis Probable oxidoreductase 0.0091 0.0726 0.393
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0158 0.0266
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0628 0.0628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.008 0.0628 0.1121
Schistosoma mansoni ap endonuclease 0.003 0.0199 0.0373
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0461
Onchocerca volvulus 0.0027 0.0174 0.043
Brugia malayi Nuclear hormone receptor family member nhr-40 0.008 0.0628 0.1121
Plasmodium falciparum thioredoxin reductase 0.0036 0.0251 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.01 0.0509
Loa Loa (eye worm) hypothetical protein 0.0137 0.1123 0.2023
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0265 0.0498
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0082 0.0647 0.3499
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0054 0.0054
Mycobacterium tuberculosis Probable hydrolase 0.0034 0.0238 0.1265
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0009 0.0017 0.0031
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0012 0.0049 0.0146
Schistosoma mansoni lamin 0.0027 0.0174 0.0327
Echinococcus multilocularis neutral alpha glucosidase AB 0.0143 0.1176 0.1176
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.01 0.0509
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.0141 0.0236
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0034 0.0238 0.0412
Trichomonas vaginalis set domain proteins, putative 0.0227 0.1899 0.6878
Mycobacterium ulcerans fatty-acid-CoA ligase 0.003 0.0199 0.0665
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0054 0.0097
Schistosoma mansoni alpha-glucosidase 0.0557 0.4732 0.8891
Schistosoma mansoni cytochrome P450 0.0018 0.01 0.0187
Brugia malayi Steroid receptor seven-up type 2 0.008 0.0628 0.1121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.008 0.0628 0.1121
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0046 0.0339 0.0339
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.01 0.0302
Echinococcus granulosus dnaJ subfamily B 0.0331 0.2789 0.5064
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0012 0.0049 0.1349
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.01 0.0302
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.01 0.0509
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.1579 0.1579
Echinococcus multilocularis musashi 0.0027 0.0174 0.0174
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0046 0.0339 0.0615
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0008 0.0012 0.0012
Brugia malayi nuclear receptor RXR 0.0042 0.0304 0.0532
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.01 0.0302
Brugia malayi Glycosyl hydrolases family 31 protein 0.0143 0.1176 0.212
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0199 0.1052
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.002 0.0016
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0192 0.0348
Leishmania major hypothetical protein, conserved 0.0034 0.0238 0.0765
Plasmodium vivax SET domain protein, putative 0.0029 0.0192 0.7475
Brugia malayi beta-lactamase 0.0034 0.0238 0.0413
Toxoplasma gondii ABC1 family protein 0.0034 0.0238 0.1908
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0199 0.0665
Schistosoma mansoni Tr4/Tr2 (homologue) 0.008 0.0628 0.1179
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.01 0.0302
Giardia lamblia Fructose-bisphosphate aldolase 0.0185 0.1531 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.022 0.1838 1
Leishmania major GTP-binding protein, putative 0.0013 0.0057 0.0173
Echinococcus multilocularis lysosomal alpha glucosidase 0.0647 0.5507 0.5507
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0009 0.0017 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0017 0.0057
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.003 0.0199 0.0663
Loa Loa (eye worm) hypothetical protein 0.008 0.0628 0.1121
Loa Loa (eye worm) hypothetical protein 0.0034 0.0238 0.0412
Onchocerca volvulus 0.0023 0.0141 0.0344
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.01 0.0302
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0053 0.0401 0.1298
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0238 0.0765
Treponema pallidum fructose-bisphosphate aldolase 0.0185 0.1531 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0053 0.0401 0.142
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.002 0.0016
Trypanosoma brucei C-8 sterol isomerase, putative 0.0363 0.3066 1
Mycobacterium tuberculosis Conserved protein 0.0034 0.0238 0.1265
Brugia malayi exodeoxyribonuclease III family protein 0.003 0.0199 0.0341
Brugia malayi RNA, U transporter 1 0.0052 0.0387 0.0684
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.009 0.0718 0.3884
Trichomonas vaginalis alpha-glucosidase, putative 0.0053 0.0401 0.142
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.01 0.0302
Leishmania major glycosyl hydrolase-like protein 0.0053 0.0401 0.1298
Mycobacterium ulcerans aldehyde dehydrogenase 0.0046 0.0339 0.1175
Brugia malayi steroid hormone receptor 0.008 0.0628 0.1121
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0446 0.3784 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0009 0.0017 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0238 0.0826
Plasmodium vivax thioredoxin reductase, putative 0.0036 0.0251 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0304 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-41 0.008 0.0628 0.1121
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.003 0.0199 0.7768
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0174 0.0295
Brugia malayi AMP-binding enzyme family protein 0.003 0.0199 0.0342
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0158 0.0515
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0066 0.0099
Echinococcus multilocularis thyroid hormone receptor alpha 0.008 0.0628 0.0628
Echinococcus multilocularis survival motor neuron protein 1 0.0199 0.1658 0.1658
Toxoplasma gondii exonuclease III APE 0.003 0.0199 0.1567
Echinococcus granulosus survival motor neuron protein 1 0.0199 0.1658 0.3011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0017 0.001
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0013 0.0057 0.013
Loa Loa (eye worm) oxidoreductase 0.0009 0.0017 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.1579 0.2967
Toxoplasma gondii aldehyde dehydrogenase 0.0046 0.0339 0.2776
Schistosoma mansoni retinoid-x-receptor (RXR) 0.008 0.0628 0.1179
Loa Loa (eye worm) hypothetical protein 0.0034 0.0238 0.0412
Echinococcus granulosus FTZ F1 alpha 0.008 0.0628 0.114
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0053 0.0401 0.142
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.01 0.0509
Trichomonas vaginalis glutathione reductase, putative 0.0012 0.0049 0.0135
Onchocerca volvulus Protein ultraspiracle homolog 0.008 0.0628 0.1633
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0192 0.036
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.0628 0.1121
Loa Loa (eye worm) steroid hormone receptor 0.008 0.0628 0.1121
Echinococcus granulosus lamin 0.0027 0.0174 0.0316
Entamoeba histolytica Ran family GTPase 0.0013 0.0057 0.0297
Trichomonas vaginalis ran, putative 0.0013 0.0057 0.0164
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0143 0.1176 1
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0265 0.0498
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.008 0.0628 0.114
Schistosoma mansoni cpg binding protein 0.0023 0.0141 0.0265
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0034 0.0238 0.1265
Brugia malayi CXXC zinc finger family protein 0.0023 0.0141 0.0236
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.01 0.0302
Mycobacterium ulcerans hypothetical protein 0.0034 0.0238 0.0808
Trypanosoma brucei glucosidase, putative 0.0143 0.1176 0.3802
Brugia malayi Pre-SET motif family protein 0.0029 0.0192 0.0328
Schistosoma mansoni ran 0.0013 0.0057 0.0107
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0265 0.0481
Plasmodium falciparum glutathione reductase 0.0036 0.0251 1
Loa Loa (eye worm) thioredoxin reductase 0.0036 0.0251 0.0435
Mycobacterium tuberculosis Conserved protein 0.0034 0.0238 0.1265
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0265 0.0265
Echinococcus multilocularis importin subunit beta 1 0.0018 0.0098 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0199 0.0665
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.008 0.0628 0.1121
Loa Loa (eye worm) beta-lactamase 0.0034 0.0238 0.0412
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0034 0.0238 0.0808
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.01 0.0313
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.0012 0.0021
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0143 0.1176 0.7666
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0041 0.0291 0.051
Brugia malayi Thioredoxin reductase 0.0036 0.0251 0.0436
Brugia malayi nuclear receptor NHR-88 0.0038 0.0265 0.0461
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0265 0.0461
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0017 0.001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0012 0.0049 0.0103
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0158 0.0266
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0363 0.3066 1
Brugia malayi Cytochrome P450 family protein 0.007 0.0542 0.0965
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0009 0.0017 0.001
Trichomonas vaginalis penicillin-binding protein, putative 0.0034 0.0238 0.0826
Leishmania major C-8 sterol isomerase-like protein 0.0363 0.3066 1
Loa Loa (eye worm) hypothetical protein 0.0199 0.1658 0.2996
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0034 0.0238 0.1265
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0304 0.0532
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0195 0.1616 0.2919
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0185 0.1531 0.5538
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0461
Onchocerca volvulus 0.0038 0.0265 0.0672
Brugia malayi intermediate filament protein 0.0027 0.0174 0.0296
Echinococcus granulosus lysosomal alpha glucosidase 0.0647 0.5507 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0012 0.0022
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0042 0.0304 0.0304
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0049 0.0146
Toxoplasma gondii HEAT repeat-containing protein 0.0018 0.0098 0.07
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0009 0.0017 0.0057
Onchocerca volvulus 0.0009 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0461
Brugia malayi Cytochrome P450 family protein 0.0018 0.01 0.0161
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.1579 0.2853
Echinococcus multilocularis tumor protein p63 0.0383 0.3239 0.3239
Loa Loa (eye worm) hypothetical protein 0.0053 0.0401 0.0709
Schistosoma mansoni thyroid hormone receptor 0.008 0.0628 0.1179
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.01 0.0302
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.1176 0.3829
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.008 0.0628 0.114
Onchocerca volvulus 0.0041 0.0291 0.0742
Echinococcus multilocularis cpg binding protein 0.0025 0.0153 0.0153
Mycobacterium tuberculosis Probable lipase LipE 0.0034 0.0238 0.1265
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0082 0.0647 0.3499
Loa Loa (eye worm) hypothetical protein 0.008 0.0628 0.1121
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0185 0.1531 1
Brugia malayi hypothetical protein 0.0095 0.0763 0.1368
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0022 0.0134 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0158 0.0266
Loa Loa (eye worm) glutathione reductase 0.0036 0.0251 0.0435
Leishmania major acetyl-CoA synthetase, putative 0.0009 0.0017 0.0043
Loa Loa (eye worm) hypothetical protein 0.008 0.0628 0.1121
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.003 0.0199 0.0361
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0012 0.0049 0.0115
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0012 0.0049 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.008 0.0628 0.1121
Mycobacterium ulcerans hypothetical protein 0.003 0.0199 0.0665
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0009 0.0017 0.001
Echinococcus multilocularis expressed protein 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0461
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0017 0.0057
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.01 0.0313
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0022 0.0134 0.0696
Schistosoma mansoni cpg binding protein 0.0025 0.0153 0.0287
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.0012 0.0022
Onchocerca volvulus 0.0029 0.0192 0.0478
Loa Loa (eye worm) hypothetical protein 0.008 0.0628 0.1121
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0012 0.0049 0.0115
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0009 0.0017 0.0057
Trichomonas vaginalis alpha-glucosidase, putative 0.0143 0.1176 0.4245
Brugia malayi Nuclear hormone receptor family member nhr-3 0.008 0.0628 0.1121
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0461
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0265 0.0481
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0013 0.0057 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-31 0.008 0.0628 0.1121
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0046 0.0339 0.1814
Schistosoma mansoni importin beta-1 0.0018 0.0098 0.0184
Onchocerca volvulus 0.0034 0.0238 0.06
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0049 0.0146
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0174 0.0296
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0238 0.0826
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0009 0.0017 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0143 0.1176 0.4245
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0068 0.0207
Brugia malayi ecdysteroid receptor 0.008 0.0628 0.1121
Brugia malayi beta-lactamase family protein 0.0034 0.0238 0.0413
Loa Loa (eye worm) hypothetical protein 0.003 0.0199 0.0341
Brugia malayi nuclear receptor NHR-88 0.008 0.0628 0.1121
Brugia malayi Importin beta-1 subunit 0.0018 0.0098 0.0158
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.0295
Echinococcus multilocularis vesicular acetylcholine transporter 0.0446 0.3784 0.3784
Loa Loa (eye worm) glutaminase 0.0327 0.2755 0.4992
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0017 0.0043
Trichomonas vaginalis D-aminoacylase, putative 0.0034 0.0238 0.0826
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.0012 0.0022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0066 0.0099
Loa Loa (eye worm) hypothetical protein 0.0042 0.0304 0.0532
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0123 0.0639
Loa Loa (eye worm) hypothetical protein 0.0042 0.0304 0.0532
Trichomonas vaginalis mercuric reductase, putative 0.0012 0.0049 0.0135
Toxoplasma gondii NADPH-glutathione reductase 0.0012 0.0049 0.0272
Loa Loa (eye worm) hypothetical protein 0.0018 0.0098 0.0157
Loa Loa (eye worm) hypothetical protein 0.0042 0.0304 0.0532
Echinococcus multilocularis dnaJ subfamily B 0.0331 0.2789 0.2789
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0185 0.1531 0.5538
Echinococcus granulosus thioredoxin glutathione reductase 0.0036 0.0251 0.0455
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.008 0.0628 0.1179
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0009 0.0017 0.0057
Echinococcus multilocularis thioredoxin glutathione reductase 0.0036 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0363 0.3066 0.5559
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0013 0.0057 0.1698
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.01 0.0509
Schistosoma mansoni hypothetical protein 0.0041 0.0291 0.0548
Brugia malayi Pre-SET motif family protein 0.02 0.1662 0.3003
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.01 0.0509
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.003 0.0199 0.0636
Loa Loa (eye worm) DR-78 0.0038 0.0265 0.0461
Loa Loa (eye worm) hypothetical protein 0.0095 0.0763 0.1368
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0013 0.0057 0.0342
Trypanosoma brucei trypanothione reductase 0.0036 0.0251 0.0767
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0192 0.0192
Toxoplasma gondii thioredoxin reductase 0.0036 0.0251 0.2017
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0012 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0195 0.1616 0.3035
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0012 0.0049 0.0088
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.01 0.0271
Loa Loa (eye worm) hypothetical protein 0.0034 0.0238 0.0412
Mycobacterium tuberculosis Probable lipase LipD 0.0034 0.0238 0.1265
Echinococcus multilocularis geminin 0.0625 0.5322 0.5322
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0082 0.0647 0.8889
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.01 0.0302
Brugia malayi nuclear receptor RXR 0.0038 0.0265 0.0461
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0186 0.1539 0.2778
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.1579 0.1579
Brugia malayi nuclear receptor NHR-67 0.0038 0.0265 0.0461
Brugia malayi glutathione reductase 0.0036 0.0251 0.0436
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0265 0.0461
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0461
Trypanosoma cruzi trypanothione reductase, putative 0.0012 0.0049 0.0146
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0251 0.0807
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0013 0.0057 0.0055
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0042 0.0304 0.0571
Trichomonas vaginalis antibiotic synthetase, putative 0.0009 0.0017 0.002
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0012 0.0049 0.1349
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0069
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0008 0.0012 0.0022
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0446 0.3784 0.6865
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.0012 0.0012
Schistosoma mansoni aldehyde dehydrogenase 0.0046 0.0339 0.0637
Loa Loa (eye worm) histone methyltransferase 0.0008 0.0012 0.0001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.008 0.0628 0.114
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0013 0.0057 0.0173
Echinococcus granulosus retinoic acid receptor rxr beta a 0.008 0.0628 0.114
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.009 0.0718 0.256
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.01 0.0302
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0185 0.1531 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0053 0.0401 0.2564
Schistosoma mansoni alpha glucosidase 0.0143 0.1176 0.221
Onchocerca volvulus 0.0374 0.316 0.8347
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.01 0.0181
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0091 0.0726 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.008 0.0628 0.1121
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.01 0.0302
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.01 0.0302
Plasmodium falciparum thioredoxin reductase 0.0012 0.0049 0.1349
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0013 0.0057 0.0057
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.01 0.0302
Leishmania major acetyl-CoA synthetase, putative 0.0009 0.0017 0.0043
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.003 0.0199 0.0665
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.003 0.0199 1
Echinococcus multilocularis ecdysone induced protein 78C 0.008 0.0628 0.0628
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0034 0.0238 0.0413
Mycobacterium tuberculosis Probable reductase 0.0082 0.0647 0.3499
Schistosoma mansoni intermediate filament proteins 0.0027 0.0174 0.0327
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0009 0.0017 0.0057
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.0012 0.0012
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0265 0.0461
Echinococcus granulosus snurportin 1 0.0195 0.1616 0.2934
Schistosoma mansoni survival motor neuron protein 0.0041 0.0291 0.0548
Brugia malayi Cytochrome P450 family protein 0.0025 0.0158 0.0267
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.008 0.0628 0.1121
Leishmania major cytochrome p450-like protein 0.0018 0.01 0.0313
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0012 0.0049 0.0091
Brugia malayi ecdysone receptor 0.0038 0.0265 0.0461
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0069
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0265 0.0461
Plasmodium falciparum acyl-CoA synthetase 0.0022 0.0134 0.5003
Echinococcus granulosus importin subunit beta 1 0.0018 0.0098 0.0178
Brugia malayi hypothetical protein 0.0199 0.1658 0.2996
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0238 0.9458
Trichomonas vaginalis maltase-glucoamylase, putative 0.0143 0.1176 0.4245
Leishmania major cytochrome p450-like protein 0.0025 0.0158 0.0504
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0647 0.5507 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0009 0.0017 0.0043
Loa Loa (eye worm) hypothetical protein 0.0042 0.0304 0.0532
Brugia malayi nuclear hormone receptor 0.008 0.0628 0.1121
Entamoeba histolytica exodeoxyribonuclease III, putative 0.003 0.0199 0.1231
Plasmodium vivax glutathione reductase, putative 0.0036 0.0251 1
Brugia malayi cytochrome P450 0.0018 0.01 0.0161
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.01 0.0302
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.0012 0.0012
Brugia malayi hypothetical protein 0.0042 0.0304 0.0532
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.008 0.0628 0.1121
Schistosoma mansoni coup transcription factor 0.008 0.0628 0.1179
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0012 0.0049 0.023
Brugia malayi AMP-binding enzyme family protein 0.003 0.0199 0.0342
Schistosoma mansoni retinoic acid receptor RXR 0.008 0.0628 0.1179
Mycobacterium leprae Probable lipase LipE 0.0034 0.0238 0.3118
Trypanosoma brucei importin beta-1 subunit, putative 0.0018 0.0098 0.0266
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.003 0.0199 0.2569
Plasmodium falciparum importin beta, putative 0.0018 0.0098 0.3469
Echinococcus multilocularis lamin dm0 0.0027 0.0174 0.0174
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.01 0.1165
Brugia malayi Nuclear hormone receptor family member nhr-49 0.008 0.0628 0.1121
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0012 0.0049 0.1349
Echinococcus granulosus ecdysone induced protein 78C 0.008 0.0628 0.114
Loa Loa (eye worm) hypothetical protein 0.0022 0.0134 0.0223
Onchocerca volvulus 0.0038 0.0265 0.0672
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.01 0.0302
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0461
Loa Loa (eye worm) hypothetical protein 0.0022 0.0134 0.0223
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0265 0.0672
Trichomonas vaginalis alpha-glucosidase, putative 0.0143 0.1176 0.4245
Schistosoma mansoni nuclear receptor 0.0038 0.0265 0.0498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.008 0.0628 0.1121
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.003 0.0199 0.1012
Loa Loa (eye worm) hypothetical protein 0.008 0.0628 0.1121
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.003 0.0199 0.2569
Trichomonas vaginalis esterase, putative 0.0034 0.0238 0.0826
Schistosoma mansoni hypothetical protein 0.0018 0.01 0.0187
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.01 0.0509
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.0012 0.0021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0192 0.0328
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0288
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.003 0.0199 0.1049
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0012 0.0049 0.1349
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0265 0.0461
Mycobacterium ulcerans beta-lactamase 0.0034 0.0238 0.0808
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0053 0.0401 0.1033
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.003 0.0199 0.0636
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0238 0.0765
Echinococcus multilocularis beta LACTamase domain containing family member 0.0034 0.0238 0.0238
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0012 0.0049 0.0103
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0628 0.114
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.1579 0.2868
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0265 0.0481

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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