pI: 9.3384 |
Length (AA): 569 |
MW (Da): 66540 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intraerythrocytic - 12 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intraerythrocytic - 6 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 48 hs. | Zhu L |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intraerythrocytic - 40 hs. | Zhu L |
Zhu L | New insights into the Plasmodium vivax transcriptome using RNA-Seq. |
Ortholog group members (OG5_128200)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G19450 | diacylglycerol O-acyltransferase 1 |
Babesia bovis | BBOV_IV004970 | diacylglycerol acyltransferase, putative |
Brugia malayi | Bm1_52020 | diacylglycerol acyltransferase |
Candida albicans | CaO19.9788 | Acyl-CoA cholesterol acyltransferase |
Candida albicans | CaO19.2248 | Acyl-CoA cholesterol acyltransferase |
Caenorhabditis elegans | CELE_H19N07.4 | Protein MBOA-2, isoform B |
Cryptosporidium hominis | Chro.20121 | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme |
Cryptosporidium parvum | cgd2_1090 | diacylglycerol acyltransferase 1 |
Dictyostelium discoideum | DDB_G0271342 | diacylglycerol O-acyltransferase 1 |
Drosophila melanogaster | Dmel_CG31991 | midway |
Echinococcus granulosus | EgrG_000645000 | diacylglycerol O acyltransferase 1 |
Echinococcus multilocularis | EmuJ_000645000 | diacylglycerol O acyltransferase 1 |
Homo sapiens | ENSG00000185000 | diacylglycerol O-acyltransferase 1 |
Loa Loa (eye worm) | LOAG_07245 | diacylglycerol acyltransferase |
Loa Loa (eye worm) | LOAG_07246 | hypothetical protein |
Mus musculus | ENSMUSG00000022555 | diacylglycerol O-acyltransferase 1 |
Neospora caninum | NCLIV_024240 | sterol O-acyltransferase, putative |
Neospora caninum | NCLIV_032680 | diacylglycerol acyltransferase, putative |
Oryza sativa | 4341317 | Os06g0563900 |
Oryza sativa | 4338045 | Os05g0196800 |
Plasmodium berghei | PBANKA_1216200 | diacylglycerol O-acyltransferase, putative |
Plasmodium falciparum | PF3D7_0322300 | diacylglycerol O-acyltransferase |
Plasmodium knowlesi | PKNH_0818500 | diacylglycerol O-acyltransferase, putative |
Plasmodium vivax | PVX_095120 | diacylglycerol O-acyltransferase, putative |
Plasmodium yoelii | PY01256 | acyl transferase-related |
Saccharomyces cerevisiae | YNR019W | Are2p |
Schistosoma japonicum | Sjp_0108570 | Diacylglycerol O-acyltransferase 1, putative |
Schistosoma japonicum | Sjp_0108620 | ko:K00635 diacylglycerol O-acyltransferase [EC2.3.1.20], putative |
Schistosoma japonicum | Sjp_0305310 | Diacylglycerol O-acyltransferase 1, putative |
Schistosoma mansoni | Smp_127280 | diacylglycerol O-acyltransferase 1 |
Schmidtea mediterranea | mk4.004258.00 | Diacylglycerol O-acyltransferase 1 |
Toxoplasma gondii | TGME49_232730 | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme |
Toxoplasma gondii | TGME49_263710 | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha |
Theileria parva | TP01_0247 | diacylglycerol O-acyltransferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1216200 | Plasmodium berghei | Essential | plasmo |
TGME49_232730 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_263710 | Toxoplasma gondii | Essentiality uncertain | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.4
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | Diacylglycerol O-acyltransferase 1 | Compounds | References |
Canis familiaris | O-acyltransferase | Compounds | References |
Homo sapiens | diacylglycerol O-acyltransferase 1 | Compounds | References |
Mus musculus | diacylglycerol O-acyltransferase 1 | Compounds | References |