Detailed view for LOAG_05281

Basic information

TDR Targets ID: 946731
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 10.8559 | Length (AA): 147 | MW (Da): 15324 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130097)

Species Accession Gene Product
Caenorhabditis elegans CELE_F08A10.1   Protein KCNL-2, isoform E
Caenorhabditis elegans CELE_F08A10.1a   Protein KCNL-2, isoform C
Drosophila melanogaster Dmel_CG10706   small conductance calcium-activated potassium channel
Echinococcus granulosus EgrG_001027800   small conductance calcium activated potassium
Echinococcus multilocularis EmuJ_001027800   small conductance calcium activated potassium
Homo sapiens ENSG00000080709   potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Homo sapiens ENSG00000143603   potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Homo sapiens 3780   potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
Loa Loa (eye worm) LOAG_05281   hypothetical protein
Loa Loa (eye worm) LOAG_05282   hypothetical protein
Mus musculus ENSMUSG00000002908   potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
Mus musculus ENSMUSG00000054477   potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Mus musculus 140493   potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Schistosoma japonicum Sjp_0092380   Small conductance calcium-activated potassium channel protein, putative
Schistosoma japonicum Sjp_0101760   ko:K04942 potassium intermediate/small conductance calcium-activated channel,, putative
Schistosoma japonicum Sjp_0101340   expressed protein
Schistosoma japonicum Sjp_0309480   ko:K01047 phospholipase A2 [EC3.1.1.4], putative
Schistosoma japonicum Sjp_0116410   Small conductance calcium-activated potassium channel protein, putative
Schistosoma japonicum Sjp_0103540   IPR011996,SK channel region,domain-containing
Schistosoma mansoni Smp_156150   calcium-activated potassium channel
Schistosoma mansoni Smp_139410   hypothetical protein
Schmidtea mediterranea mk4.016505.01   Small conductance calcium-activated potassium channel protein
Schmidtea mediterranea mk4.005084.02  
Schmidtea mediterranea mk4.008073.00   Small conductance calcium-activated potassium channel protein
Schmidtea mediterranea mk4.001747.01   Small conductance calcium-activated potassium channel protein
Schmidtea mediterranea mk4.004030.02   Small conductance calcium-activated potassium channel protein
Schmidtea mediterranea mk4.006837.00  
Schmidtea mediterranea mk4.000164.12   Small conductance calcium-activated potassium channel protein
Schmidtea mediterranea mk4.032884.00  
Schmidtea mediterranea mk4.001747.00   Small conductance calcium-activated potassium channel protein
Schmidtea mediterranea mk4.004873.01   Small conductance calcium-activated potassium channel protein
Schmidtea mediterranea mk4.005568.02   Small conductance calcium-activated potassium channel protein
Schmidtea mediterranea mk4.027229.00  
Schmidtea mediterranea mk4.000224.13   Small conductance calcium-activated potassium channel protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 Compounds References
Rattus norvegicus Small conductance calcium-activated potassium channel protein 2 Compounds References
Homo sapiens potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Compounds References
Rattus norvegicus Small conductance calcium-activated potassium channel protein 3 Compounds References
Rattus norvegicus Small conductance calcium-activated potassium channel protein 1 Compounds References
Homo sapiens potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0293 0.3262 0.3257
0.1205 0.3261 0.3261
0.0373 0.3623 0.362
0.1264 0.3044 0.3042
0.0686 0.2767 0.2767
0.034 0.2619 0.2555
0.1128 0.3226 0.3213
0.0452 0.2694 0.2694
0.0262 0.2756 0.3302
0.0257 0.3187 0.3383
0.00533612 0.298336 0.298336
0.0509 0.2985 0.2985
0.0121 0.2855 0.2855
0.0225 0.2732 0.2732
0.00524566 0.296798 0.296798
0.0853 0.308 0.308
0.0853 0.2712 0.2712
0.0012 0.2831 0.2831
0.0443 0.3386 0.3356
0.03 0.2554 0.2538
0.0392 0.2945 0.2945
0.0077 0.2882 0.2882
0.0434 0.3164 0.3164
0.03 0.2554 0.2538
0.1323 0.2548 0.3158
0.0951 0.3049 0.3049
0.0786 0.3281 0.3281
0.0454 0.2901 0.2901
0.1323 0.2548 0.3158
0.1323 0.2548 0.3158
0.029 0.3083 0.3083
0.0369 0.2596 0.2596
0.086 0.3283 0.3281
0.0931 0.3192 0.3192
0.0336 0.2901 0.2901
0.00524566 0.296798 0.296798
0.0336 0.2901 0.2901
0.0296 0.3087 0.3087
0.1323 0.2548 0.3158
0.1267 0.3044 0.3042
0.0067 0.2567 0.2882
0.1323 0.2548 0.3158
0.1128 0.3226 0.3213
0.0455 0.2972 0.2972
0.0454 0.2901 0.2901
0.101 0.3238 0.3238
0.0395473 0.351555 0.350167
0.0372 0.2587 0.257
0.0068 0.279 0.2138
0.01 0.2793 0.2793
0.0194 0.2585 0.3426
0.071 0.2985 0.2985
0.0373 0.3623 0.362
0.00533612 0.298336 0.298336
0.0853 0.2712 0.2712
0.0686 0.2767 0.2767
0.1135 0.3047 0.3047
0.1323 0.2548 0.3158
0.0174 0.2985 0.2985
0.0368 0.3613 0.3613
0.0853 0.2712 0.2712
0.067 0.3325 0.3323
0.0067 0.2567 0.2882
0.1205 0.3261 0.3261
0.0877 0.327 0.327
0.0225 0.3574 0.3574
0.0068 0.2522 0.1618
0.0467 0.2973 0.2973
0.0452 0.2932 0.2932
0.0877 0.327 0.327

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_05281 (Loa Loa (eye worm)), hypothetical protein
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