Detailed information for compound 1045504

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 359.506 | Formula: C21H33N3O2
  • H donors: 1 H acceptors: 3 LogP: 4.42 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1noc(n1)CC(CC(=O)NC1C2CC3CC1CC(C2)C3)(C)C)C
  • InChi: 1S/C21H33N3O2/c1-12(2)20-23-18(26-24-20)11-21(3,4)10-17(25)22-19-15-6-13-5-14(8-15)9-16(19)7-13/h12-16,19H,5-11H2,1-4H3,(H,22,25)
  • InChiKey: GPYRSWYSAFNOKE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (11-beta) dehydrogenase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans short chain dehydrogenase Get druggable targets OG5_132866 All targets in OG5_132866
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_132866 All targets in OG5_132866
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxysteroid (11-beta) dehydrogenase 1 292 aa 250 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone kinase SNF1, putative 0.01 0.0136 0.0475
Echinococcus granulosus cyclins 0.015 0.0456 0.0456
Schistosoma mansoni hypothetical protein 0.0087 0.0047 0.0057
Echinococcus multilocularis cyclins 0.015 0.0456 0.0556
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0331 0.163 0.199
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0205 0.088
Giardia lamblia Kinase, AGC AKT 0.0128 0.0316 0.1195
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0558 0.0682
Schistosoma mansoni tyrosine kinase 0.0849 0.4986 0.6088
Schistosoma mansoni serine/threonine protein kinase 0.0267 0.1217 0.1486
Brugia malayi Stress-activated protein kinase jnk-1 0.0277 0.1278 0.156
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0162 0.0537 0.0655
Onchocerca volvulus 0.0522 0.2868 0.8695
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0156 0.0496 0.2466
Brugia malayi SH2 domain containing protein 0.0087 0.0047 0.0057
Trichomonas vaginalis cyclin A, putative 0.0247 0.1083 0.5329
Echinococcus multilocularis myosin iiia 0.0096 0.0105 0.0128
Loa Loa (eye worm) TK protein kinase 0.0375 0.1915 0.2339
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0336 0.166 0.2027
Echinococcus granulosus serine threonine protein kinase 0.0149 0.0451 0.0451
Echinococcus granulosus tyrosine kinase 0.0156 0.0496 0.0496
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0303 0.1376
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0434 0.2297 0.2805
Onchocerca volvulus 0.0328 0.1612 0.4886
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0197 0.0765 0.0934
Plasmodium vivax unspecified product 0.0111 0.0205 0.1986
Schistosoma mansoni tyrosine kinase 0.0297 0.1409 0.172
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0147 0.0439 0.1574
Schistosoma mansoni protein kinase 0.0239 0.1036 0.1265
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0098 0.012 0.0147
Loa Loa (eye worm) hypothetical protein 0.0392 0.2028 0.2477
Entamoeba histolytica protein kinase, putative 0.0189 0.0713 0.3577
Giardia lamblia Kinase, CMGC GSK 0.0189 0.0713 0.333
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0094 0.0115
Loa Loa (eye worm) hypothetical protein 0.0112 0.021 0.0257
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0219 0.0903 0.0903
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.0496 0.0605
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.0496 0.0605
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0432 0.2282 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0089 0.0061 0.0074
Entamoeba histolytica protein kinase, putative 0.0149 0.0451 0.2234
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.032 0.039
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0166 0.0558 0.0558
Echinococcus granulosus SH2 domain containing adapter protein F 0.0087 0.0047 0.0047
Giardia lamblia Hypothetical protein 0.015 0.0456 0.1945
Loa Loa (eye worm) hypothetical protein 0.0129 0.032 0.0391
Onchocerca volvulus Serine\/threonine kinase homolog 0.038 0.1951 0.5916
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0166 0.0558 0.212
Schistosoma mansoni vav2 0.0146 0.0433 0.0529
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.027 0.1233 0.1506
Echinococcus multilocularis tyrosine protein kinase Blk 0.0245 0.107 0.1307
Echinococcus multilocularis casein kinase I gamma 0.0225 0.0944 0.1153
Echinococcus multilocularis cyclins 0.015 0.0456 0.0556
Brugia malayi SH2 domain containing protein 0.0462 0.2477 0.3025
Loa Loa (eye worm) hypothetical protein 0.0087 0.0047 0.0057
Trichomonas vaginalis STE family protein kinase 0.0113 0.0219 0.0946
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0297 0.1409 0.1409
Schistosoma mansoni tyrosine kinase 0.0493 0.2679 0.3271
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0166 0.0558 0.212
Trichomonas vaginalis AGC family protein kinase 0.0342 0.1702 0.8465
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0112 0.021 0.2041
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0113 0.0215 0.0262
Echinococcus granulosus tyrosine protein kinase Fyn 0.0297 0.1409 0.1409
Brugia malayi Serine/threonine-protein kinase SULU 0.043 0.2272 0.2774
Toxoplasma gondii AGC kinase 0.0331 0.163 1
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0508 0.278 0.3395
Brugia malayi Protein kinase domain containing protein 0.0531 0.2926 0.3572
Brugia malayi Tensin 0.0087 0.0047 0.0057
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0432 0.2282 1
Schistosoma mansoni serine/threonine-protein kinase 0.0201 0.0785 0.0958
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0937 0.5562 0.6791
Brugia malayi intracellular kinase 0.0189 0.0713 0.087
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0166 0.0558 0.6038
Trichomonas vaginalis cyclin B, putative 0.0247 0.1083 0.5329
Echinococcus granulosus serine:threonine kinase SAD 1 0.01 0.0136 0.0136
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0615 0.347 0.4237
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0214 0.0875 0.0875
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0113 0.0215 0.0551
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0432 0.2282 1
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.015 0.0459 0.1668
Schistosoma mansoni protein kinase 0.0447 0.2386 0.2913
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0261 0.0319
Schistosoma mansoni hypothetical protein 0.0113 0.0215 0.0262
Echinococcus granulosus serine:threonine protein kinase 0.0084 0.0032 0.0032
Giardia lamblia Kinase, NEK 0.0147 0.0441 0.1865
Entamoeba histolytica protein kinase, putative 0.0091 0.0077 0.032
Giardia lamblia Kinase, CDC7 0.0328 0.1612 0.8171
Plasmodium falciparum casein kinase 1 0.012 0.0261 0.2379
Echinococcus multilocularis casein kinase I delta 0.012 0.0261 0.0319
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0113 0.0215 0.0262
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0233 0.0284
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0182 0.0662 0.0808
Loa Loa (eye worm) AUR protein kinase 0.0217 0.0889 0.1085
Brugia malayi STAT protein, DNA binding domain containing protein 0.0087 0.0047 0.0057
Brugia malayi Protein kinase domain containing protein 0.0198 0.0769 0.0939
Schistosoma mansoni kinase 0.0351 0.1759 0.2148
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0166 0.0558 0.212
Echinococcus granulosus cyclin dependent kinase 9 0.009 0.0069 0.0069
Entamoeba histolytica cyclin family protein 0.015 0.0456 0.2259
Plasmodium vivax serine/threonine protein kinase, putative 0.0094 0.0094 0.071
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.021 0.0904
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0198 0.0769 0.0939
Loa Loa (eye worm) hypothetical protein 0.0113 0.0215 0.0262
Loa Loa (eye worm) hypothetical protein 0.0085 0.0038 0.0046
Loa Loa (eye worm) hypothetical protein 0.03 0.1429 0.1745
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0236 0.1014 0.1238
Brugia malayi Protein kinase domain containing protein 0.0522 0.2868 0.3502
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0432 0.2282 1
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.01 0.0136 0.0188
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0128 0.0317 0.0388
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0087 0.0047 0.0057
Brugia malayi serine/threonine-protein kinase 6 0.0217 0.0889 0.1085
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0297 0.1409 0.172
Loa Loa (eye worm) hypothetical protein 0.012 0.0262 0.032
Schistosoma mansoni protein kinase 0.0277 0.1282 0.1565
Loa Loa (eye worm) hypothetical protein 0.0425 0.224 0.2735
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0266 0.121 0.1478
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Entamoeba histolytica protein kinase domain containing protein 0.009 0.0069 0.0282
Entamoeba histolytica protein kinase domain containing protein 0.0111 0.0205 0.0979
Loa Loa (eye worm) AGC/PKA protein kinase 0.0166 0.0558 0.0682
Echinococcus granulosus mitogen activated protein kinase 0.0147 0.0439 0.0439
Loa Loa (eye worm) TK/KIN16 protein kinase 0.071 0.4089 0.4993
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0113 0.0216 0.0555
Trichomonas vaginalis CMGC family protein kinase 0.0328 0.1612 0.801
Mycobacterium ulcerans hypothetical protein 0.0102 0.0149 0.0544
Brugia malayi C1-like domain containing protein 0.0236 0.1014 0.1238
Loa Loa (eye worm) hypothetical protein 0.0098 0.0119 0.0145
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.069 0.3337
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0089 0.0061 0.0326
Brugia malayi Protein kinase domain containing protein 0.0311 0.15 0.1831
Brugia malayi ephrin receptor 1 precursor 0.01 0.0131 0.016
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0089 0.0061 0.5
Echinococcus multilocularis mitogen activated protein kinase 11 0.0432 0.2282 0.2787
Echinococcus granulosus cyclin B3 1 0.015 0.0456 0.0456
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0531 0.2926 0.3572
Toxoplasma gondii hypothetical protein 0.0109 0.0189 0.0813
Echinococcus granulosus NCK adaptor protein 0.0139 0.0385 0.0385
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0094 0.0096 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0069 0.0085
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0087 0.0047 0.0047
Echinococcus granulosus tyrosine protein kinase Src42A 0.0297 0.1409 0.1409
Schistosoma mansoni cyclin B 0.0247 0.1083 0.1323
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0109 0.0189 0.1792
Loa Loa (eye worm) hypothetical protein 0.0087 0.0047 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Plasmodium vivax protein kinase Crk2 0.0219 0.0903 1
Brugia malayi Protein kinase domain containing protein 0.0176 0.0623 0.0761
Echinococcus multilocularis serine:threonine protein kinase 0.0084 0.0032 0.0039
Trichomonas vaginalis cyclins, putative 0.0247 0.1083 0.5329
Trichomonas vaginalis CMGC family protein kinase 0.0328 0.1612 0.801
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0081 0.001 0.0012
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0087 0.0047 0.0057
Schistosoma mansoni growth factor receptor-bound protein 0.0139 0.0385 0.047
Echinococcus multilocularis serine:threonine protein kinase N2 0.0316 0.1531 0.1869
Schistosoma mansoni tyrosine kinase 0.0208 0.0834 0.1019
Plasmodium falciparum calcium-dependent protein kinase 5 0.0112 0.021 0.1773
Loa Loa (eye worm) hypothetical protein 0.0081 0.001 0.0012
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0094 0.0094 0.0213
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0092 0.0081 0.0235
Echinococcus multilocularis casein kinase ii subunit alpha 0.0111 0.0205 0.0251
Trypanosoma brucei SNF1-related protein kinases, putative 0.01 0.0136 0.0188
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0166 0.0558 0.0558
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0266 0.121 0.1478
Brugia malayi Immunoglobulin I-set domain containing protein 0.0397 0.2056 0.251
Brugia malayi Protein kinase domain containing protein 0.0205 0.0811 0.099
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0205 0.088
Brugia malayi Protein kinase domain containing protein 0.0219 0.0903 0.1103
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0166 0.0558 0.0558
Echinococcus granulosus serine:threonine protein kinase N2 0.0316 0.1531 0.1531
Echinococcus granulosus fibroblast growth factor receptor 4 0.0372 0.1893 0.1893
Loa Loa (eye worm) TK/ABL protein kinase 0.0579 0.3241 0.3957
Plasmodium falciparum protein kinase 5 0.0219 0.0903 1
Trichomonas vaginalis AGC family protein kinase 0.0217 0.0889 0.4343
Schistosoma mansoni serine/threonine protein kinase 0.0386 0.1988 0.2427
Echinococcus multilocularis rac serine:threonine kinase 0.0201 0.0785 0.0958
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0197 0.0765 0.0934
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0462 0.2481 0.3029
Loa Loa (eye worm) AGC/PKN protein kinase 0.0316 0.1531 0.1869
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0096 0.0105 0.0046
Schistosoma mansoni serine/threonine protein kinase 0.0169 0.0582 0.0711
Echinococcus multilocularis casein kinase i 0.012 0.0261 0.0319
Plasmodium falciparum casein kinase 2, alpha subunit 0.0111 0.0205 0.1716
Brugia malayi Hr1 repeat family protein 0.0316 0.1531 0.1869
Loa Loa (eye worm) hypothetical protein 0.0166 0.0558 0.0682
Plasmodium vivax tyrosine kinase-like protein, putative 0.0092 0.0081 0.0553
Echinococcus granulosus suppressor of cytokine signaling 7 0.0087 0.0047 0.0047
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.01 0.0136 0.0188
Entamoeba histolytica protein kinase, putative 0.0102 0.0149 0.069
Echinococcus granulosus expressed protein 0.0094 0.0094 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.038 0.1951 0.2383
Loa Loa (eye worm) hypothetical protein 0.0124 0.0287 0.0351
Entamoeba histolytica protein kinase, putative 0.013 0.0329 0.161
Echinococcus granulosus serine:threonine protein kinase NIM1 0.0129 0.032 0.032
Brugia malayi serine/threonine-protein kinase PAK 7 0.0434 0.2297 0.2805
Echinococcus granulosus insulin receptor 0.0927 0.5491 0.5491
Echinococcus granulosus SH2 domain containing protein 7 0.0087 0.0047 0.0047
Schistosoma mansoni protein kinase 0.0091 0.0077 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0328 0.1612 0.1968
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0089 0.0061 0.0074
Loa Loa (eye worm) AUR protein kinase 0.0217 0.0889 0.1085
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0136 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0233 0.0284
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0147 0.0439 0.0536
Schistosoma mansoni tensin 0.0087 0.0047 0.0057
Schistosoma mansoni serine/threonine kinase 0.0206 0.0822 0.1004
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0245 0.107 0.1307
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0214 0.0875 0.1068
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0139 0.0388 0.1344
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0205 0.0811 0.099
Entamoeba histolytica protein kinase domain containing protein 0.0217 0.0889 0.4477
Schistosoma mansoni serine/threonine-protein kinase 0.0201 0.0785 0.0958
Brugia malayi SRC-1 0.0297 0.1409 0.172
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0112 0.021 0.0952
Echinococcus multilocularis growth factor receptor bound protein 2 0.0139 0.0385 0.047
Brugia malayi Protein kinase domain containing protein 0.0156 0.0496 0.0605
Brugia malayi P38 map kinase family protein 2 0.0432 0.2282 0.2787
Echinococcus granulosus calcium activated potassium channel 0.0115 0.0233 0.0233
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0082 0.0014 0.0017
Echinococcus granulosus expressed conserved protein 0.0087 0.0047 0.0047
Trichomonas vaginalis AGC family protein kinase 0.0217 0.0889 0.4343
Schistosoma mansoni serine/threonine protein kinase 0.015 0.0459 0.0561
Giardia lamblia Kinase, NEK 0.0147 0.0441 0.1865
Brugia malayi Fibronectin type III domain containing protein 0.0139 0.0388 0.0474
Entamoeba histolytica protein kinase, putative 0.0112 0.021 0.1003
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0122 0.0276 0.0337
Entamoeba histolytica protein kinase domain containing protein 0.0189 0.0713 0.3577
Schistosoma mansoni tyrosine kinase 0.0849 0.4986 0.6088
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0205 0.088
Entamoeba histolytica serine/threonine protein kinase, putative 0.038 0.1951 0.9919
Echinococcus granulosus tyrosine protein kinase Fyn 0.0297 0.1409 0.1409
Echinococcus multilocularis insulin receptor 0.0927 0.5491 0.6705
Loa Loa (eye worm) hypothetical protein 0.0127 0.0311 0.038
Loa Loa (eye worm) hypothetical protein 0.0231 0.0984 0.1201
Loa Loa (eye worm) hypothetical protein 0.0087 0.0047 0.0057
Loa Loa (eye worm) SH2 domain-containing protein 0.0087 0.0047 0.0057
Loa Loa (eye worm) hypothetical protein 0.0234 0.1 0.1221
Echinococcus multilocularis raf serine:threonine protein kinase 0.0118 0.0248 0.0303
Loa Loa (eye worm) cyclin domain-containing protein 0.0265 0.1205 0.1472
Schistosoma mansoni tyrosine kinase 0.0372 0.1893 0.2312
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.01 0.0136 0.0165
Loa Loa (eye worm) hypothetical protein 0.0175 0.0621 0.0759
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0189 0.0713 0.087
Entamoeba histolytica protein kinase, putative 0.0185 0.0684 0.3428
Trypanosoma cruzi cyclin, putative 0.0247 0.1083 0.4519
Schistosoma mansoni serine/threonine protein kinase 0.0594 0.3337 0.4074
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.0496 0.0605
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0166 0.0558 0.0682
Brugia malayi kinase, mitochondrial precursor 0.0124 0.0287 0.0351
Loa Loa (eye worm) AGC/AKT protein kinase 0.0342 0.1702 0.2078
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0265 0.1205 0.1205
Plasmodium vivax glycogen synthase kinase 3, putative 0.0189 0.0713 0.7815
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0126 0.0303 0.037
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.027 0.1233 0.1233
Onchocerca volvulus 0.0203 0.0804 0.2437
Loa Loa (eye worm) hypothetical protein 0.0097 0.0113 0.0138
Onchocerca volvulus 0.0113 0.0215 0.0651
Echinococcus multilocularis tyrosine protein kinase shark 0.0813 0.4753 0.5803
Loa Loa (eye worm) hypothetical protein 0.014 0.0391 0.0478
Schistosoma mansoni serine/threonine kinase 0.0185 0.0684 0.0835
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0096 0.0105 0.0462
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0136 0.0165
Echinococcus granulosus tyrosine protein kinase Lyn 0.034 0.169 0.169
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0112 0.021 0.0257
Echinococcus multilocularis casein kinase I alpha 0.012 0.0261 0.0319
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0118 0.025 0.0305
Leishmania major developmentally regulated phosphoprotein-like protein 0.0124 0.0287 0.0881
Brugia malayi Protein kinase domain containing protein 0.0084 0.0032 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.015 0.0456 0.2148
Echinococcus granulosus roundabout 2 0.0183 0.0671 0.0671
Brugia malayi Protein kinase domain containing protein 0.0185 0.0684 0.0835
Schistosoma mansoni protein kinase 0.0111 0.0205 0.0251
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0082 0.0014 0.0014
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0266 0.121 0.121
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0531 0.2926 0.3572
Echinococcus multilocularis casein kinase I delta 0.012 0.0261 0.0319
Echinococcus multilocularis cyclin B3 1 0.015 0.0456 0.0556
Giardia lamblia Kinase, CMGC DYRK 0.015 0.0459 0.1965
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0135 0.0361 0.0441
Trichomonas vaginalis CMGC family protein kinase 0.0189 0.0713 0.3452
Echinococcus multilocularis dual specificity 0.015 0.0459 0.0561
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.012 0.0261 0.0319
Loa Loa (eye worm) hypothetical protein 0.0203 0.0804 0.0982
Entamoeba histolytica p21-activated kinase 0.0124 0.0291 0.1415
Brugia malayi hypothetical protein 0.0113 0.0215 0.0262
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0139 0.0385 0.047
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0462 0.2477 0.2477
Brugia malayi Protein kinase domain containing protein 0.0615 0.347 0.4237
Leishmania major casein kinase, putative 0.012 0.0261 0.0763
Echinococcus multilocularis mitogen activated protein kinase 14 0.0432 0.2282 0.2787
Loa Loa (eye worm) hypothetical protein 0.0089 0.0061 0.0074
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0147 0.0441 0.2421
Echinococcus granulosus casein kinase I alpha 0.012 0.0261 0.0261
Trypanosoma cruzi cdc2-related kinase 1 0.0219 0.0903 0.3696
Echinococcus granulosus Vam6:Vps39 protein 0.0113 0.0215 0.0215
Onchocerca volvulus 0.0294 0.1393 0.4224
Schistosoma mansoni ephrin receptor 0.008 0.0005 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.027 0.1233 0.1506
Echinococcus granulosus cyclin dependent kinase 5 0.0219 0.0903 0.0903
Plasmodium falciparum serine/threonine protein kinase KIN 0.01 0.0136 0.0885
Entamoeba histolytica cyclin family protein 0.015 0.0456 0.2259
Mycobacterium tuberculosis Probable oxidoreductase 0.0338 0.1676 0.5
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0937 0.5562 0.5562
Trypanosoma cruzi Protein kinase B 0.0201 0.0785 0.3156
Echinococcus multilocularis serine threonine protein kinase 0.0149 0.0451 0.055
Brugia malayi Immunoglobulin I-set domain containing protein 0.0139 0.0388 0.0474
Schistosoma mansoni suppressor of cytokine signaling 0.0087 0.0047 0.0057
Echinococcus multilocularis SH2 domain containing protein 7 0.0087 0.0047 0.0057
Onchocerca volvulus 0.0087 0.0047 0.0142
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0477 0.2576 0.3146
Loa Loa (eye worm) hypothetical protein 0.0172 0.06 0.0732
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0447 0.2386 0.2386
Leishmania major protein kinase, putative 0.0217 0.0889 0.363
Loa Loa (eye worm) hypothetical protein 0.0247 0.1083 0.1323
Entamoeba histolytica protein kinase, putative 0.015 0.0459 0.2278
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.0496 0.0605
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0189 0.0713 0.0713
Trichomonas vaginalis CMGC family protein kinase 0.015 0.0459 0.2167
Entamoeba histolytica PH domain containing protein kinase, putative 0.0201 0.0785 0.3946
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0156 0.0498 0.0498
Echinococcus multilocularis dual specificity 0.015 0.0459 0.0561
Brugia malayi Immunoglobulin I-set domain containing protein 0.071 0.4089 0.4993
Loa Loa (eye worm) hypothetical protein 0.0188 0.0705 0.0861
Echinococcus multilocularis tyrosine protein kinase HCK 0.0158 0.0509 0.0621
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0112 0.021 0.021
Schistosoma mansoni tensin-related 0.0087 0.0047 0.0057
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0336 0.166 0.2027
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0112 0.021 0.021
Brugia malayi Tyrosine-protein kinase abl-1 0.0262 0.1181 0.1441
Toxoplasma gondii AGC kinase 0.0166 0.0558 0.317
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0245 0.107 0.107
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0084 0.0263
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0217 0.0889 0.4477
Giardia lamblia Kinase, STE STE20 0.0113 0.0219 0.0668
Echinococcus multilocularis protein tyrosine kinase 0.0331 0.1631 0.1991
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0217 0.0889 0.4477
Echinococcus granulosus c-Jun N-terminal kinases 0.0277 0.1278 0.1278
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0233 0.0284
Echinococcus multilocularis cyclin dependent kinase 9 0.0098 0.0122 0.0149
Brugia malayi SH2 domain containing protein 0.0156 0.0496 0.0605
Trichomonas vaginalis AGC family protein kinase 0.0342 0.1702 0.8465
Echinococcus multilocularis signal transduction protein lnk realted 0.0087 0.0047 0.0057
Loa Loa (eye worm) hypothetical protein 0.0247 0.1083 0.1323
Trypanosoma cruzi polo-like protein kinase, putative 0.038 0.1951 0.8487
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0205 0.088
Loa Loa (eye worm) casein kinase 0.0182 0.0662 0.0809
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0185 0.0684 0.0835
Entamoeba histolytica protein kinase domain containing protein 0.0113 0.0216 0.1032
Trichomonas vaginalis CK1 family protein kinase 0.012 0.0261 0.1163
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0277 0.1278 0.156
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0558 0.0682
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0135 0.0361 0.0441
Brugia malayi map kinase activated protein kinase protein 2 0.0594 0.3337 0.4074
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0219 0.0903 0.5368
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.015 0.0459 0.2539
Brugia malayi Furin-like cysteine rich region family protein 0.1343 0.819 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0112 0.021 0.1773
Onchocerca volvulus 0.0087 0.0047 0.0142
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0297 0.1409 0.172
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0113 0.0215 0.0262
Echinococcus granulosus nervana 2 0.0146 0.0431 0.0431
Schistosoma mansoni vam6/vps39 related 0.0113 0.0215 0.0262
Trichomonas vaginalis STE family protein kinase 0.0113 0.0219 0.0946
Trichomonas vaginalis STE family protein kinase 0.0149 0.0451 0.2123
Echinococcus granulosus protein kinase C gamma type 0.0268 0.1225 0.1225
Echinococcus granulosus c src tyrosine kinase 0.0208 0.0834 0.0834
Brugia malayi Serine/threonine-protein kinase Nek7 0.0258 0.1156 0.1412
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0372 0.1893 0.2312
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0139 0.0385 0.047
Plasmodium falciparum NIMA related kinase 1 0.0147 0.0441 0.4511
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0014 0.0017
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0087 0.0047 0.0057
Brugia malayi Protein kinase domain containing protein 0.0362 0.1834 0.2239
Leishmania major protein kinase A catalytic subunit 0.0166 0.0558 0.212
Echinococcus granulosus nervana 2 0.0146 0.0431 0.0431
Echinococcus granulosus dual specificity 0.015 0.0459 0.0459
Echinococcus multilocularis SH2 motif 0.0087 0.0047 0.0057
Schistosoma mansoni tyrosine kinase 0.0726 0.4191 0.5117
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0297 0.1409 0.172
Trypanosoma brucei Casein kinase II 0.0111 0.0205 0.0508
Brugia malayi casein kinase I 0.012 0.0261 0.0319
Trypanosoma cruzi casein kinase II, putative 0.0111 0.0205 0.0508
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.0496 0.0605
Trypanosoma cruzi casein kinase, putative 0.012 0.0261 0.0763
Schistosoma mansoni tyrosine kinase 0.0208 0.0834 0.1019
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0112 0.021 0.0529
Echinococcus multilocularis tyrosine protein kinase Srms 0.0245 0.107 0.1307
Brugia malayi Protein kinase domain containing protein 0.0462 0.2481 0.3029
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0219 0.0903 0.1103
Brugia malayi Cyclin, N-terminal domain containing protein 0.0247 0.1083 0.1323
Trichomonas vaginalis AGC family protein kinase 0.0101 0.0137 0.0532
Schistosoma mansoni vesicular amine transporter 0.0128 0.0317 0.0388
Brugia malayi hypothetical protein 0.0156 0.0496 0.0605
Echinococcus multilocularis cyclin dependent kinase 1 0.0219 0.0903 0.1103
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0247 0.1083 0.4519
Echinococcus granulosus growth factor receptor bound protein 2 0.0141 0.0398 0.0398
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0094 0.0094 0.0115
Loa Loa (eye worm) NEK/NEK6 protein kinase 0.0258 0.1156 0.1412
Entamoeba histolytica protein kinase, putative 0.0114 0.0227 0.1089
Plasmodium falciparum cGMP-dependent protein kinase 0.0146 0.0431 0.4391
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.043 0.2272 0.2774
Loa Loa (eye worm) TK/FER protein kinase 0.0462 0.2477 0.3025
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0579 0.3241 0.3957
Schistosoma mansoni tensin 0.0087 0.0047 0.0057
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0477 0.2576 0.2576
Echinococcus granulosus rho-associated protein kinase 1 0.0338 0.1675 0.1675
Brugia malayi hypothetical protein 0.043 0.2272 0.2774
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0297 0.1409 0.172
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0101 0.0137 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.038 0.1951 0.9731
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0146 0.0431 0.0526
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.038 0.1951 0.2383
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0297 0.1409 0.172
Trichomonas vaginalis CAMK family protein kinase 0.0198 0.0769 0.3737
Echinococcus multilocularis expressed conserved protein 0.0146 0.0431 0.0526
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0253 0.1127 0.1127
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0136 0.0165
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Onchocerca volvulus 0.012 0.0261 0.0792
Brugia malayi Protein kinase domain containing protein 0.0386 0.1988 0.2427
Loa Loa (eye worm) TK/INSR protein kinase 0.0927 0.5491 0.6705
Loa Loa (eye worm) hypothetical protein 0.0615 0.347 0.4237
Echinococcus multilocularis serine:threonine protein kinase N2 0.0185 0.0684 0.0835
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.021 0.0257
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0141 0.0402 0.1876
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0189 0.0713 0.0713
Echinococcus multilocularis expressed protein 0.0094 0.0094 0.0115
Leishmania major protein kinase A catalytic subunit isoform 2 0.0166 0.0558 0.212
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0166 0.0558 0.317
Schistosoma mansoni tyrosine kinase 0.0113 0.0217 0.0264
Loa Loa (eye worm) hypothetical protein 0.0113 0.0215 0.0262
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0087 0.0047 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0342 0.1702 0.8465
Trypanosoma cruzi casein kinase, putative 0.012 0.0261 0.0763
Entamoeba histolytica protein kinase domain containing protein 0.015 0.0459 0.2278
Schistosoma mansoni protein kinase 0.0165 0.0552 0.0674
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0147 0.0439 0.1574
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0112 0.021 0.0257
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0124 0.0287 0.0351
Brugia malayi Variant SH3 domain containing protein 0.0139 0.0385 0.047
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.01 0.0136 0.0188
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0113 0.0219 0.0219
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0113 0.0215 0.0551
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0092 0.0084 0.0084
Brugia malayi putative serine/threonine kinase SADA gamma 0.01 0.0136 0.0165
Echinococcus granulosus aurora kinase A 0.0217 0.0889 0.0889
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0189 0.0713 0.087
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0087 0.0047 0.0047
Giardia lamblia Kinase, CMGC MAPK 0.0147 0.0439 0.1855
Schistosoma mansoni serine/threonine protein kinase 0.0236 0.1014 0.1239
Trypanosoma brucei mitotic cyclin 6 0.0247 0.1083 0.4519
Schistosoma mansoni serine/threonine protein kinase 0.0258 0.1156 0.1412
Schistosoma mansoni serine/threonine protein kinase 0.0316 0.1531 0.1869
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0253 0.1127 0.1376
Giardia lamblia Kinase, CAMK CAMKL 0.0109 0.0189 0.0507
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0189 0.0713 0.774
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0177 0.0634 0.0775
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0217 0.0889 0.4477
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0201 0.0785 0.3156
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0113 0.0216 0.0555
Brugia malayi Doublecortin family protein 0.0162 0.0537 0.0655
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Mycobacterium ulcerans short chain dehydrogenase 0.0338 0.1676 1
Trichomonas vaginalis AGC family protein kinase 0.0342 0.1702 0.8465
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.038 0.1951 0.2383
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0187 0.07 0.0854
Echinococcus granulosus N chimaerin 0.0135 0.0361 0.0361
Brugia malayi tRNA modification GTPase TrmE family protein 0.0087 0.0047 0.0057
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0372 0.1893 0.1893
Schistosoma mansoni serine/threonine protein kinase 0.0185 0.0684 0.0835
Brugia malayi Protein kinase domain containing protein 0.0118 0.025 0.0305
Brugia malayi Variant SH3 domain containing protein 0.0139 0.0385 0.047
Echinococcus multilocularis tensin 0.0087 0.0047 0.0057
Giardia lamblia Kinase, CMGC CDK 0.0219 0.0903 0.4354
Trichomonas vaginalis CK1 family protein kinase 0.012 0.0261 0.1163
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0124 0.0287 0.0351
Trypanosoma brucei polo-like protein kinase 0.038 0.1951 0.8487
Echinococcus granulosus tyrosine protein kinase ABL1 0.0579 0.3241 0.3241
Onchocerca volvulus 0.0156 0.0496 0.1503
Echinococcus multilocularis serine threonine protein kinase 0.0268 0.1225 0.1496
Trichomonas vaginalis CAMK family protein kinase 0.038 0.1951 0.9731
Echinococcus granulosus serine threonine protein kinase nrc 0.0189 0.0713 0.0713
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0432 0.2282 0.2787
Giardia lamblia Kinase, CK1 Casein kinase 0.012 0.0261 0.0899
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.0903 0.1103
Toxoplasma gondii aurora kinase 0.0217 0.0889 0.5277
Trypanosoma brucei protein kinase, putative 0.0113 0.0216 0.0555
Entamoeba histolytica PH domain containing protein kinase, putative 0.0201 0.0785 0.3946
Echinococcus granulosus casein kinase ii subunit alpha 0.0111 0.0205 0.0205
Echinococcus multilocularis cyclin dependent kinase 9 0.009 0.0069 0.0085
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0364 0.1843 0.225
Echinococcus granulosus Protein kinase C brain isozyme 0.0317 0.1539 0.1539
Brugia malayi SH2 domain containing protein 0.0087 0.0047 0.0057
Trichomonas vaginalis CMGC family protein kinase 0.015 0.0459 0.2167
Brugia malayi Cyclin, N-terminal domain containing protein 0.0287 0.1343 0.164
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0147 0.0438 0.0438
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0096 0.0105 0.0462
Entamoeba histolytica protein kinase 2, putative 0.0189 0.0713 0.3576
Echinococcus multilocularis dual specificity 0.015 0.0459 0.0561
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0113 0.0219 0.0219
Echinococcus granulosus casein kinase I alpha 0.012 0.0261 0.0261
Echinococcus granulosus casein kinase i 0.012 0.0261 0.0261
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0096 0.0105 0.0046
Entamoeba histolytica protein kinase domain containing protein 0.0214 0.0875 0.4407
Trichomonas vaginalis CAMK family protein kinase 0.0389 0.2004 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.1051 0.1283
Onchocerca volvulus 0.0096 0.0105 0.0319
Plasmodium vivax casein kinase 1, putative 0.012 0.0261 0.2628
Echinococcus multilocularis Immunoglobulin 0.0128 0.0317 0.0388
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0197 0.0765 0.0934
Loa Loa (eye worm) hypothetical protein 0.0139 0.0385 0.047
Giardia lamblia Kinase, TTK 0.0118 0.025 0.0838
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0118 0.025 0.0305
Echinococcus granulosus epidermal growth factor receptor 0.1343 0.819 0.819
Echinococcus multilocularis casein kinase I alpha 0.012 0.0261 0.0319
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0439 0.0536
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.038 0.1947 0.1947
Trichomonas vaginalis AGC family protein kinase 0.0342 0.1702 0.8465
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0185 0.0684 0.0835
Brugia malayi hypothetical protein 0.0127 0.0311 0.038
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0128 0.0317 0.0388
Onchocerca volvulus 0.0328 0.1612 0.4886
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0176 0.0623 0.0761
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0165 0.0552 0.0674
Brugia malayi Protein kinase domain containing protein 0.0552 0.3065 0.3743
Echinococcus multilocularis mitogen activated protein kinase 11 0.0432 0.2282 0.2787
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0219 0.0903 0.3696
Echinococcus multilocularis rho associated protein kinase 0.0338 0.1675 0.2045
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.0136 0.0621
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.015 0.0459 0.0561
Schistosoma mansoni adapter molecule crk 0.0139 0.0385 0.047
Echinococcus granulosus cyclin b3 0.015 0.0456 0.0456
Brugia malayi protein kinase C3,putative 0.0175 0.0622 0.076
Trichomonas vaginalis CMGC family protein kinase 0.0147 0.0439 0.2063
Echinococcus granulosus tyrosine protein kinase Src42A 0.0177 0.0634 0.0634
Onchocerca volvulus 0.0156 0.0496 0.1503
Brugia malayi cell division control protein 2 homolog 0.0219 0.0903 0.1103
Plasmodium falciparum cyclin 0.015 0.0456 0.4686
Schistosoma mansoni protein kinase 0.0113 0.0219 0.0267
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0431 0.0526
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0176 0.0623 0.0761
Echinococcus multilocularis serine:threonine protein kinase 38 0.0185 0.0684 0.0835
Schistosoma mansoni protein kinase C mu 0.0236 0.1014 0.1238
Giardia lamblia Kinase, CMGC CDK 0.0219 0.0903 0.4354
Entamoeba histolytica protein kinase domain containing protein 0.0189 0.0713 0.3577
Loa Loa (eye worm) hypothetical protein 0.0128 0.0317 0.0388
Loa Loa (eye worm) AGC/NDR protein kinase 0.0185 0.0684 0.0835
Schistosoma mansoni protein kinase 0.0113 0.0219 0.0267
Loa Loa (eye worm) hypothetical protein 0.0192 0.0732 0.0894
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.0889 0.1085
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.043 0.2272 0.2774
Loa Loa (eye worm) hypothetical protein 0.0156 0.0496 0.0605
Onchocerca volvulus 0.0087 0.0047 0.0142
Onchocerca volvulus 0.0129 0.032 0.0969
Echinococcus multilocularis cyclins 0.015 0.0456 0.0556
Echinococcus multilocularis protein kinase c iota type 0.0317 0.1539 0.1879
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.015 0.0459 0.1668
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Echinococcus granulosus cyclins 0.015 0.0456 0.0456
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0156 0.0498 0.0498
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0918 0.5435 0.5435
Brugia malayi Protein kinase domain containing protein 0.0156 0.0496 0.0605
Schistosoma mansoni protein kinase 0.0113 0.0216 0.0264
Echinococcus multilocularis mitogen activated protein kinase 0.0147 0.0439 0.0536
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0219 0.0903 0.1103
Schistosoma mansoni pyruvate dehydrogenase 0.0117 0.0243 0.0296
Entamoeba histolytica protein kinase, putative 0.0331 0.163 0.8271
Schistosoma mansoni serine/threonine protein kinase 0.0277 0.1278 0.156
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0185 0.0684 0.0835
Echinococcus multilocularis 0.0165 0.0552 0.0674
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0112 0.021 0.0257
Loa Loa (eye worm) hypothetical protein 0.0128 0.0317 0.0388
Loa Loa (eye worm) AGC/PKA protein kinase 0.0166 0.0558 0.0682
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0135 0.0361 0.0441
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.0558 0.0682
Entamoeba histolytica protein kinase, putative 0.0342 0.1702 0.8641
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0508 0.278 0.278
Giardia lamblia Cyclin A 0.015 0.0456 0.1945
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0087 0.0047 0.0057
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0135 0.0361 0.0361
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0166 0.0558 0.0682
Entamoeba histolytica protein kinase, putative 0.0217 0.0889 0.4477
Echinococcus granulosus serine:threonine protein kinase 3 0.0269 0.1229 0.1229
Brugia malayi Protein kinase domain containing protein 0.0927 0.5491 0.6705
Loa Loa (eye worm) hypothetical protein 0.0172 0.06 0.0732
Plasmodium falciparum protein kinase, putative 0.0113 0.0216 0.1839
Echinococcus multilocularis calcium activated potassium channel 0.0115 0.0233 0.0284
Brugia malayi Temporarily assigned gene name protein 59 0.0113 0.0215 0.0262
Schistosoma mansoni tyrosine kinase 0.0427 0.2251 0.2749
Echinococcus granulosus suppressor of cytokine signaling 6 0.0087 0.0047 0.0047
Brugia malayi protein kinase C II. 0.0236 0.1014 0.1239
Entamoeba histolytica protein kinase, putative 0.0158 0.0509 0.253
Loa Loa (eye worm) hypothetical protein 0.0139 0.0388 0.0474
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0462 0.2477 0.3025
Loa Loa (eye worm) cyclin domain-containing protein 0.0287 0.1343 0.164
Echinococcus multilocularis Immunoglobulin 0.0128 0.0317 0.0388
Schistosoma mansoni tyrosine kinase 0.0918 0.5435 0.6636
Brugia malayi Casein kinase II, alpha chain 0.0111 0.0205 0.0251
Brugia malayi Tyrosine-protein kinase abl-1 0.037 0.1884 0.23
Trichomonas vaginalis cyclins, putative 0.0138 0.038 0.1763
Leishmania major protein kinase, putative 0.0112 0.021 0.0529
Brugia malayi Protein kinase domain containing protein 0.0185 0.0684 0.0835
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0087 0.0047 0.0057
Trypanosoma brucei cdc2-related kinase 3 0.0219 0.0903 0.3696
Onchocerca volvulus 0.0156 0.0496 0.1503
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0531 0.2926 0.8869
Echinococcus granulosus serine:threonine protein kinase TAO1 0.043 0.2272 0.2272
Giardia lamblia Kinase, CAMK CAMKL 0.0109 0.0189 0.0507
Echinococcus granulosus tyrosine protein kinase Fyn 0.0297 0.1409 0.1409
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0147 0.0439 0.1574
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0297 0.1409 0.1409
Echinococcus multilocularis mitogen activated protein kinase 14 0.0432 0.2282 0.2787
Schistosoma mansoni tyrosine kinase 0.0927 0.5491 0.6705
Trypanosoma cruzi casein kinase, delta isoform, putative 0.012 0.0261 0.0763
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0531 0.2926 0.3572
Schistosoma mansoni shc transforming protein 0.0087 0.0047 0.0057
Schistosoma mansoni protein kinase 0.0447 0.2386 0.2913
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0248 0.0303
Brugia malayi Sex muscle abnormal protein 5 0.0139 0.0385 0.047
Leishmania major protein kinase, putative 0.0113 0.0216 0.0555
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0189 0.0713 0.087
Onchocerca volvulus 0.0144 0.0418 0.1267
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0087 0.0047 0.0057
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0214 0.0875 0.1068
Trichomonas vaginalis STE family protein kinase 0.0147 0.0441 0.2073
Echinococcus granulosus Immunoglobulin 0.0128 0.0317 0.0317
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0087 0.0047 0.0142
Loa Loa (eye worm) TK/ROR protein kinase 0.0094 0.0096 0.0118
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0297 0.1409 0.172
Trichomonas vaginalis AGC family protein kinase 0.0217 0.0889 0.4343
Trichomonas vaginalis CAMK family protein kinase 0.038 0.1951 0.9731
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0128 0.0316 0.0386
Schistosoma mansoni tyrosine kinase 0.0918 0.5435 0.6636
Schistosoma mansoni tyrosine kinase 0.0117 0.0244 0.0298
Toxoplasma gondii AGC kinase 0.0166 0.0558 0.317
Trypanosoma brucei developmentally regulated phosphoprotein 0.0124 0.0287 0.0881
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0089 0.0061 0.5
Loa Loa (eye worm) hypothetical protein 0.0392 0.2028 0.2477
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0087 0.0047 0.0057
Brugia malayi Protein kinase c protein 2 0.0175 0.0622 0.076
Schistosoma mansoni serine/threonine protein kinase 0.0253 0.1127 0.1376
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0189 0.0713 0.2826
Trichomonas vaginalis CMGC family protein kinase 0.015 0.0459 0.2167
Echinococcus multilocularis cyclins 0.015 0.0456 0.0556
Schistosoma mansoni cyclins 0.015 0.0456 0.0556
Echinococcus multilocularis serine:threonine protein kinase 0.0084 0.0032 0.0039
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0185 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0127 0.0311 0.038
Onchocerca volvulus 0.0338 0.1675 0.5078
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0084 0.0032 0.0039
Giardia lamblia G2/mitotic-specific cyclin B 0.0247 0.1083 0.5324
Trichomonas vaginalis cyclins, putative 0.0247 0.1083 0.5329
Brugia malayi Protein kinase domain containing protein 0.0094 0.0094 0.0115
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0156 0.0498 0.0608
Schistosoma mansoni ephrin receptor 0.0134 0.0352 0.043
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0087 0.0047 0.0057
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.038 0.1947 0.2377
Plasmodium falciparum calcium-dependent protein kinase 3 0.0112 0.021 0.1773
Entamoeba histolytica casein kinase, putative 0.012 0.0261 0.1265
Echinococcus multilocularis SH2 motif 0.0087 0.0047 0.0057
Giardia lamblia Kinase, AGC PKA 0.0189 0.0713 0.333
Trypanosoma cruzi casein kinase, putative 0.012 0.0261 0.0763
Loa Loa (eye worm) STAT protein 0.0087 0.0047 0.0057
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0317 0.1539 0.1879
Trypanosoma brucei rac serine-threonine kinase, putative 0.0342 0.1702 0.7346
Loa Loa (eye worm) hypothetical protein 0.0087 0.0047 0.0057
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0185 0.0684 0.0684
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0087 0.0047 0.0057
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0112 0.021 0.2041
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0113 0.0219 0.0267
Echinococcus multilocularis aurora kinase A 0.0217 0.0889 0.1085
Plasmodium falciparum glycogen synthase kinase 3 0.0189 0.0713 0.7741
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0166 0.0558 0.0682
Schistosoma mansoni cell adhesion molecule 0.0158 0.0508 0.0621
Echinococcus granulosus tensin 0.0087 0.0047 0.0047
Echinococcus granulosus twitchin 0.0197 0.0761 0.0761
Echinococcus multilocularis cyclin B 0.0247 0.1083 0.1323
Echinococcus multilocularis tyrosine kinase 0.0156 0.0496 0.0605
Echinococcus granulosus serine:threonine protein kinase PLK1 0.038 0.1951 0.1951
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0447 0.2386 0.2913
Brugia malayi STE20-like kinase MST 0.0269 0.1229 0.1501
Trypanosoma brucei aurora B kinase 0.0217 0.0889 0.363
Schistosoma mansoni signal transduction protein lnk-related 0.0087 0.0047 0.0057
Echinococcus granulosus ephrin type A receptor 4 A 0.0134 0.0352 0.0352
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0594 0.3337 0.4074
Loa Loa (eye worm) TK protein kinase 0.0158 0.0509 0.0621
Echinococcus multilocularis nervana 2 0.0146 0.0431 0.0526
Schistosoma mansoni protein kinase 0.0447 0.2386 0.2913
Echinococcus granulosus cGMP dependent protein kinase 1 0.0146 0.0431 0.0431
Entamoeba histolytica casein kinase, putative 0.0111 0.0205 0.0979
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Loa Loa (eye worm) TK/FAK protein kinase 0.0334 0.1651 0.2016
Trypanosoma cruzi SNF1-related protein kinases, putative 0.01 0.0136 0.0188
Loa Loa (eye worm) hypothetical protein 0.014 0.0391 0.0478
Trypanosoma cruzi aurora B kinase, putative 0.0217 0.0889 0.363
Echinococcus granulosus casein kinase I alpha 0.012 0.0261 0.0261
Echinococcus granulosus dual specificity 0.015 0.0459 0.0459
Trichomonas vaginalis CAMK family protein kinase 0.0186 0.069 0.3337
Plasmodium falciparum serine/threonine protein kinase 0.0094 0.0094 0.0397
Trichomonas vaginalis AGC family protein kinase 0.0166 0.0558 0.2668
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0166 0.0558 0.212
Entamoeba histolytica protein kinase, putative 0.0113 0.0219 0.1046
Onchocerca volvulus Tyrosine kinase homolog 0.0588 0.3299 1
Entamoeba histolytica protein kinase, putative 0.0092 0.0084 0.0356
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.038 0.1951 0.8487
Echinococcus multilocularis SH2 motif 0.0087 0.0047 0.0057
Loa Loa (eye worm) hypothetical protein 0.0465 0.2499 0.3051
Schistosoma mansoni serine/threonine protein kinase 0.0185 0.0684 0.0835
Trichomonas vaginalis STE family protein kinase 0.0113 0.0219 0.0946
Schistosoma mansoni protein kinase 0.012 0.0261 0.0319
Leishmania major protein kinase A catalytic subunit isoform 1 0.0166 0.0558 0.212
Onchocerca volvulus 0.0156 0.0496 0.1503
Echinococcus granulosus Glutaredoxin protein 5 0.0146 0.0431 0.0431
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0531 0.2926 0.3572
Echinococcus multilocularis RNA directed DNA polymerase 0.0081 0.001 0.0012
Schistosoma mansoni suppressor of cytokine signaling 0.0087 0.0047 0.0057
Loa Loa (eye worm) AUR protein kinase 0.0217 0.0889 0.1085
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0113 0.0216 0.0555
Echinococcus multilocularis serine:threonine protein kinase N2 0.0131 0.0332 0.0405
Giardia lamblia Kinase, AGC PKA 0.0166 0.0558 0.2497
Entamoeba histolytica cell division protein kinase 2, putative 0.0227 0.0956 0.4822
Brugia malayi cyclin-dependent kinase 9 0.009 0.0069 0.0085
Echinococcus multilocularis cyclin b3 0.015 0.0456 0.0556
Loa Loa (eye worm) CAMK/CAMKL/NIM1 protein kinase 0.0129 0.032 0.039
Brugia malayi cell division control protein 2 homolog 0.0129 0.032 0.039
Brugia malayi serine/threonine kinase 12 0.0217 0.0889 0.1085
Loa Loa (eye worm) STE/STE20/YSK protein kinase 0.0149 0.0451 0.055
Loa Loa (eye worm) TK/EGFR protein kinase 0.1343 0.819 1
Entamoeba histolytica cyclin, putative 0.0247 0.1083 0.5473
Echinococcus granulosus NDR protein kinase 0.0185 0.0684 0.0684
Brugia malayi Protein kinase domain containing protein 0.0239 0.1036 0.1265
Echinococcus granulosus raf serine:threonine protein kinase 0.0118 0.0248 0.0248
Brugia malayi Protein kinase domain containing protein 0.0156 0.0496 0.0605
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0147 0.0439 0.1574
Schistosoma mansoni protein kinase 0.0239 0.1036 0.1265
Brugia malayi Protein kinase domain containing protein 0.0092 0.0084 0.0102
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0122 0.0276 0.0276
Trichomonas vaginalis AGC family protein kinase 0.0147 0.0441 0.2073
Echinococcus multilocularis PAK box P21 Rho binding 0.0091 0.0077 0.0094
Trichomonas vaginalis STE family protein kinase 0.0113 0.0219 0.0946
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.015 0.0459 0.0561
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0113 0.0219 0.0267
Echinococcus multilocularis roundabout 2 0.0183 0.0671 0.0819
Loa Loa (eye worm) hypothetical protein 0.0325 0.159 0.1942
Brugia malayi Fes/CIP4 homology domain containing protein 0.0129 0.0319 0.039
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0147 0.0439 0.1574
Echinococcus multilocularis SHC transforming protein 3 0.0087 0.0047 0.0057
Trichomonas vaginalis cyclin B, putative 0.0247 0.1083 0.5329
Echinococcus multilocularis serine:threonine kinase SAD 1 0.01 0.0136 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0136 0.0165
Giardia lamblia Kinase, CMGC CK2 0.0111 0.0205 0.0598
Entamoeba histolytica casein kinase 1, putative 0.012 0.0261 0.1265
Entamoeba histolytica SH2-protein kinase domain containing protein 0.013 0.0329 0.161
Trypanosoma cruzi polo-like protein kinase, putative 0.038 0.1951 0.8487
Trichomonas vaginalis CMGC family protein kinase 0.0219 0.0903 0.4416
Echinococcus multilocularis ephrin type A receptor 4 A 0.0134 0.0352 0.043
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0156 0.0497 0.0497
Trichomonas vaginalis AGC family protein kinase 0.0196 0.0756 0.3671
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0189 0.0713 0.2826
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.0623 0.0761
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0189 0.0713 0.087
Trichomonas vaginalis AGC family protein kinase 0.0342 0.1702 0.8465
Chlamydia trachomatis serine/threonine protein kinase 0.0258 0.1156 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0219 0.0903 0.1103
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0217 0.0889 0.9835
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0531 0.2926 0.2926
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0096 0.0105 0.0046
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0092 0.0081 0.0126
Onchocerca volvulus 0.0156 0.0496 0.1503
Schistosoma mansoni tyrosine kinase 0.0813 0.4753 0.5803
Loa Loa (eye worm) hypothetical protein 0.0087 0.0047 0.0057
Leishmania major protein kinase, putative 0.0096 0.0105 0.0046
Trichomonas vaginalis AGC family protein kinase 0.0342 0.1702 0.8465
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0112 0.021 0.0257
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0092 0.0084 0.0102
Schistosoma mansoni tensin-related 0.0087 0.0047 0.0057
Schistosoma mansoni tyrosine kinase 0.0297 0.1409 0.172
Echinococcus multilocularis mitogen activated protein kinase 3 0.0147 0.0439 0.0536
Loa Loa (eye worm) hypothetical protein 0.0084 0.0032 0.0039
Schistosoma mansoni protein kinase 0.0113 0.0216 0.0264
Loa Loa (eye worm) hypothetical protein 0.0087 0.0047 0.0057
Trichomonas vaginalis CMGC family protein kinase 0.0189 0.0713 0.3452
Echinococcus multilocularis epidermal growth factor receptor 0.0918 0.5435 0.6636
Loa Loa (eye worm) CDC7 protein kinase 0.0328 0.1612 0.1968
Brugia malayi serine/threonine-protein kinase plk-2 0.038 0.1951 0.2383
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0594 0.3337 0.3337
Brugia malayi MAP kinase sur-1 0.0147 0.0439 0.0536
Brugia malayi Cyclin, N-terminal domain containing protein 0.0247 0.1083 0.1323
Loa Loa (eye worm) hypothetical protein 0.0087 0.0047 0.0057
Echinococcus granulosus tyrosine protein kinase HCK 0.0158 0.0509 0.0509
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.0496 0.0605
Echinococcus multilocularis epidermal growth factor receptor 0.1343 0.819 1
Schistosoma mansoni growth factor receptor-bound protein 0.0141 0.0398 0.0486
Echinococcus granulosus cGMP dependent protein kinase 1 0.0146 0.0431 0.0431
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.025 0.1106
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.0765 0.0934
Echinococcus multilocularis protein kinase c epsilon type 0.0236 0.1014 0.1239
Trichomonas vaginalis STE family protein kinase 0.0149 0.0451 0.2123
Brugia malayi Protein kinase domain containing protein 0.0225 0.0944 0.1153
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.025 0.1106
Echinococcus granulosus mitogen activated protein kinase 11 0.0432 0.2282 0.2282
Trichomonas vaginalis CMGC family protein kinase 0.0147 0.0439 0.2063
Echinococcus multilocularis CDC7 cell division cycle 7 0.0328 0.1612 0.1968
Onchocerca volvulus 0.0494 0.2687 0.8147
Echinococcus granulosus protein kinase c epsilon type 0.0236 0.1014 0.1014
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0128 0.0317 0.0388
Brugia malayi Protein kinase domain containing protein 0.0334 0.1651 0.2016
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0189 0.0713 0.2826
Loa Loa (eye worm) hypothetical protein 0.0085 0.0038 0.0046
Schistosoma mansoni hypothetical protein 0.0087 0.0047 0.0057
Echinococcus granulosus mitogen activated protein kinase 14 0.0432 0.2282 0.2282
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0113 0.0219 0.0267
Schistosoma mansoni pyruvate dehydrogenase 0.0124 0.0287 0.0351
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0112 0.021 0.2041
Echinococcus multilocularis cyclins 0.015 0.0456 0.0556
Echinococcus granulosus activin receptor type 0.0113 0.0216 0.0216
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0113 0.0216 0.0264
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0147 0.0439 0.1574
Leishmania major casein kinase II, putative 0.0111 0.0205 0.0508
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0084 0.0102
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0214 0.0875 0.1068
Brugia malayi Protein kinase domain containing protein 0.0615 0.347 0.4237
Trichomonas vaginalis CAMK family protein kinase 0.038 0.1951 0.9731
Plasmodium falciparum calcium-dependent protein kinase 1 0.0112 0.021 0.1773
Echinococcus multilocularis tyrosine protein kinase 0.0311 0.15 0.1831
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0113 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0144 0.0418 0.051
Brugia malayi Protein kinase domain containing protein 0.0212 0.0858 0.1047
Entamoeba histolytica SH2 domain containing protein 0.0087 0.0047 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.012 0.0261 0.0319
Trichomonas vaginalis CAMK family protein kinase 0.038 0.1951 0.9731
Loa Loa (eye worm) TK protein kinase 0.0311 0.15 0.1831
Schistosoma mansoni rap gtpase-activating protein 0.0113 0.0215 0.0262
Entamoeba histolytica protein kinase, putative 0.0094 0.0094 0.041
Schistosoma mansoni ste20-related kinase 0.0217 0.0891 0.1088
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0166 0.0558 0.5905
Entamoeba histolytica protein kinase, putative 0.0094 0.0094 0.041
Trichomonas vaginalis CMGC family protein kinase 0.0219 0.0903 0.4416
Giardia lamblia Aurora kinase 0.0217 0.0889 0.4277
Echinococcus granulosus protein kinase c iota type 0.0317 0.1539 0.1539
Schistosoma mansoni protein kinase 0.038 0.1947 0.2377
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0297 0.1409 0.172
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0087 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.01 0.0136 0.0165
Loa Loa (eye worm) AGC/PKG protein kinase 0.0146 0.0431 0.0526
Brugia malayi Protein kinase domain 0.0113 0.0219 0.0267
Loa Loa (eye worm) IKK protein kinase 0.0522 0.2868 0.3502
Loa Loa (eye worm) TK protein kinase 0.0245 0.107 0.1307
Brugia malayi Cam kinase protein 1 0.0112 0.021 0.0257
Loa Loa (eye worm) hypothetical protein 0.0087 0.0047 0.0057
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0146 0.0431 0.0431
Echinococcus granulosus RNA directed DNA polymerase 0.0081 0.001 0.001
Trypanosoma brucei protein kinase, putative 0.0189 0.0713 0.2826
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Brugia malayi probable protein kinase 0.0277 0.1282 0.1565
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0959 0.5703 0.6964
Trypanosoma cruzi casein kinase, putative 0.012 0.0261 0.0763
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.038 0.1947 0.2377
Echinococcus multilocularis tyrosine protein kinase Abl 0.037 0.1884 0.23
Schistosoma mansoni serine/threonine protein kinase 0.0491 0.2667 0.3256
Trichomonas vaginalis AGC family protein kinase 0.0217 0.0889 0.4343
Echinococcus granulosus tyrosine protein kinase Blk 0.0245 0.107 0.107
Brugia malayi Protein kinase domain containing protein 0.038 0.1947 0.2377
Echinococcus multilocularis casein kinase I alpha 0.012 0.0261 0.0319
Plasmodium falciparum protein kinase, putative 0.0149 0.0451 0.4628
Trichomonas vaginalis cyclin B3, putative 0.015 0.0456 0.2148
Brugia malayi p70 ribosomal S6 kinase beta 0.0331 0.163 0.199
Schistosoma mansoni atypical protein kinase C 0.0323 0.1579 0.1928
Trypanosoma cruzi cdc2-related kinase 3 0.0219 0.0903 0.3696
Echinococcus granulosus CDC7 cell division cycle 7 0.0328 0.1612 0.1612
Brugia malayi hypothetical protein 0.0139 0.0388 0.0474
Trichomonas vaginalis CMGC family protein kinase 0.015 0.0459 0.2167
Loa Loa (eye worm) PEK/PEK protein kinase 0.0239 0.1036 0.1265
Trypanosoma cruzi cdc2-related kinase 1 0.0219 0.0903 0.3696
Plasmodium vivax calcium-dependent protein kinase, putative 0.0112 0.021 0.2041
Schistosoma mansoni nephrin 0.0164 0.055 0.0672
Loa Loa (eye worm) thyroid receptor interactor 0.0129 0.0319 0.039
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0112 0.021 0.0257
Brugia malayi Variant SH3 domain containing protein 0.0135 0.0361 0.0441
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.015 0.0459 0.1668
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0189 0.0713 0.087
Entamoeba histolytica protein kinase, putative 0.0217 0.0889 0.4477
Schistosoma mansoni serine/threonine protein kinase 0.0531 0.2926 0.3572
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0205 0.088
Schistosoma mansoni protein kinase 0.0113 0.0216 0.0264
Echinococcus granulosus cGMP dependent protein kinase 0.0146 0.0431 0.0431
Onchocerca volvulus 0.014 0.0391 0.1187
Echinococcus multilocularis serine:threonine protein kinase 3 0.0269 0.1229 0.1501
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0208 0.0834 0.1019
Trichomonas vaginalis cyclins, putative 0.015 0.0456 0.2148
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Trichomonas vaginalis STE family protein kinase 0.0096 0.0105 0.0368
Toxoplasma gondii casein kinase I 0.012 0.0261 0.1277
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0265 0.1205 0.1472
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0277 0.1278 0.156
Entamoeba histolytica protein kinase , putative 0.0217 0.0889 0.4477
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.0875 0.1068
Trichomonas vaginalis CMGC family protein kinase 0.015 0.0459 0.2167
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.0451 0.055
Echinococcus granulosus casein kinase I gamma 0.0225 0.0944 0.0944
Brugia malayi Protein kinase domain containing protein 0.0959 0.5703 0.6964
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0219 0.0903 0.3696
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0135 0.0361 0.0441
Entamoeba histolytica protein kinase, putative 0.0342 0.1702 0.8641
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0112 0.021 0.021
Trichomonas vaginalis cyclins, putative 0.0247 0.1083 0.5329
Echinococcus multilocularis death associated protein kinase 1 0.0865 0.5092 0.6218
Loa Loa (eye worm) TTK protein kinase 0.0118 0.025 0.0305
Echinococcus multilocularis serine:threonine protein kinase NIM1 0.0129 0.032 0.039
Brugia malayi Protein kinase domain containing protein 0.0328 0.1612 0.1968
Echinococcus granulosus tyrosine protein kinase Src64B 0.0297 0.1409 0.1409
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0189 0.0713 0.4155
Onchocerca volvulus 0.0087 0.0047 0.0142
Trichomonas vaginalis cyclin B, putative 0.0247 0.1083 0.5329
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.01 0.0136 0.0188
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0386 0.1987 0.1987
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0118 0.025 0.0758
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0386 0.1988 0.2427
Loa Loa (eye worm) hypothetical protein 0.0087 0.0047 0.0057
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0111 0.0205 0.1986
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0176 0.0623 0.0623
Brugia malayi Cyclin, N-terminal domain containing protein 0.0265 0.1205 0.1472
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0082 0.0014 0.0017
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0146 0.0431 0.2357
Loa Loa (eye worm) hypothetical protein 0.0144 0.0418 0.051
Echinococcus granulosus defective proboscis extension response 0.0128 0.0317 0.0317
Brugia malayi SH2 domain containing protein 0.0087 0.0047 0.0057
Trichomonas vaginalis STE family protein kinase 0.0091 0.0077 0.0228
Toxoplasma gondii CMGC kinase, CK2 family 0.0111 0.0205 0.0921
Entamoeba histolytica cell division protein kinase 2, putative 0.0219 0.0903 0.4551
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.0496 0.0605
Trypanosoma cruzi CYC2-like cyclin, putative 0.0247 0.1083 0.4519
Schistosoma mansoni GTPase activating protein 0.0087 0.0047 0.0057
Schistosoma mansoni tyrosine kinase 0.1343 0.819 1
Onchocerca volvulus 0.0247 0.1083 0.3284
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0166 0.0558 0.212
Echinococcus granulosus dual specificity 0.015 0.0459 0.0459
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0094 0.0096 0.0096
Echinococcus granulosus protein tyrosine kinase 0.0331 0.1631 0.1631
Trichomonas vaginalis CMGC family protein kinase 0.0147 0.0439 0.2063
Trichomonas vaginalis AGC family protein kinase 0.0193 0.0737 0.3573
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.027 0.1233 0.1506
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0156 0.0498 0.0498
Brugia malayi Protein kinase domain containing protein 0.0342 0.1702 0.2078
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0087 0.0047 0.0057
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0113 0.0216 0.0216
Entamoeba histolytica PH domain containing protein kinase, putative 0.0177 0.063 0.3155
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0147 0.0439 0.2409
Brugia malayi SH2 domain containing protein 0.0087 0.0047 0.0057
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0113 0.0215 0.0551
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.0903 0.1103
Brugia malayi Egg laying defective protein 4 0.0146 0.0431 0.0526
Echinococcus granulosus epidermal growth factor receptor 0.0918 0.5435 0.5435
Onchocerca volvulus 0.0156 0.0496 0.1503
Trichomonas vaginalis CAMK family protein kinase 0.038 0.1951 0.9731
Echinococcus granulosus mitogen activated protein kinase 3 0.0147 0.0439 0.0439
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.012 0.0261 0.0319
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Echinococcus granulosus cyclin dependent kinase 1 0.0219 0.0903 0.0903
Brugia malayi SH2 domain containing protein 0.0087 0.0047 0.0057
Entamoeba histolytica PH domain containing protein kinase, putative 0.0177 0.063 0.3155
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0112 0.021 0.0257
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0118 0.025 0.025
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0087 0.0047 0.0057
Trichomonas vaginalis CK1 family protein kinase 0.012 0.0261 0.1163
Echinococcus granulosus casein kinase I delta 0.012 0.0261 0.0261
Giardia lamblia Kinase, PLK 0.038 0.1951 1
Trichomonas vaginalis AGC family protein kinase 0.0185 0.0684 0.3304
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0166 0.0558 0.212
Schistosoma mansoni kinase 0.009 0.0069 0.0085
Brugia malayi Variant SH3 domain containing protein 0.01 0.0136 0.0166
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.0498 0.0608
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0297 0.1409 0.172
Brugia malayi casein kinase 1, delta 0.012 0.0261 0.0319
Schistosoma mansoni serine/threonine protein kinase 0.0317 0.1539 0.1879
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0594 0.3337 0.4074
Trichomonas vaginalis CMGC family protein kinase 0.015 0.0459 0.2167
Loa Loa (eye worm) hypothetical protein 0.0139 0.0388 0.0474
Loa Loa (eye worm) TK protein kinase 0.0397 0.2056 0.251
Loa Loa (eye worm) SH2 domain-containing protein 0.0087 0.0047 0.0057
Plasmodium falciparum calcium-dependent protein kinase 4 0.0112 0.021 0.1773
Leishmania major cyclin 0.0247 0.1083 0.4519
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0156 0.0498 0.0607
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0297 0.1409 0.172
Giardia lamblia Kinase, NEK 0.0147 0.0441 0.1865
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Loa Loa (eye worm) variant SH3 domain-containing protein 0.01 0.0136 0.0166
Trichomonas vaginalis CMGC family protein kinase 0.0147 0.0439 0.2063
Brugia malayi hypothetical protein 0.0087 0.0047 0.0057
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0217 0.0889 0.0889
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0112 0.021 0.0952
Echinococcus granulosus cyclins 0.015 0.0456 0.0456
Brugia malayi SH2 domain containing protein 0.0087 0.0047 0.0057
Echinococcus granulosus protein kinase shaggy 0.0189 0.0713 0.0713
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0166 0.0558 0.0682
Loa Loa (eye worm) hypothetical protein 0.0139 0.0388 0.0474
Brugia malayi Probable ClpP-like protease 0.0089 0.0061 0.0074
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0615 0.347 0.4237
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0124 0.0287 0.0287
Trichomonas vaginalis cyclin B, putative 0.015 0.0456 0.2148
Echinococcus granulosus cyclins 0.015 0.0456 0.0456
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.0496 0.0605
Echinococcus granulosus cyclin dependent kinase 0.0219 0.0903 0.0903
Trypanosoma cruzi cdc2-related kinase 3 0.0219 0.0903 0.3696
Echinococcus granulosus SH2 motif 0.0087 0.0047 0.0047
Onchocerca volvulus 0.0192 0.0732 0.2219
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0087 0.0047 0.0047
Echinococcus multilocularis cyclins 0.015 0.0456 0.0556
Trichomonas vaginalis CMGC family protein kinase 0.0219 0.0903 0.4416
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0197 0.0765 0.0765
Echinococcus multilocularis activin receptor type 0.0113 0.0216 0.0264
Trichomonas vaginalis AGC family protein kinase 0.0185 0.0684 0.3304
Loa Loa (eye worm) TK/ALK protein kinase 0.0552 0.3064 0.3741
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0127 0.0308 0.0377
Giardia lamblia Kinase, STE STE20 0.0096 0.0105 0.0055
Echinococcus granulosus cyclin B 0.0247 0.1083 0.1083
Schistosoma mansoni protein kinase 0.0205 0.0811 0.099
Brugia malayi protein-tyrosine kinase 0.0245 0.107 0.1307
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Schistosoma mansoni cyclin B3 0.0265 0.1205 0.1472
Trypanosoma brucei casein kinase I, isoform 2 0.012 0.0261 0.0763
Loa Loa (eye worm) TK/FER protein kinase 0.0156 0.0496 0.0605
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0089 0.0061 0.5
Plasmodium vivax serine/threonine-specific protein kinase, putative 0.0149 0.0451 0.4803
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0113 0.0216 0.0987
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0146 0.0431 0.0526
Entamoeba histolytica hypothetical protein 0.0383 0.1967 1
Echinococcus multilocularis 0.0087 0.0047 0.0057
Entamoeba histolytica protein kinase, putative 0.0102 0.0149 0.069
Schistosoma mansoni tensin 0.0087 0.0047 0.0057
Loa Loa (eye worm) hypothetical protein 0.0266 0.121 0.1478
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0124 0.0287 0.0881
Echinococcus granulosus tyrosine protein kinase 0.0311 0.15 0.15
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0139 0.0385 0.047
Echinococcus granulosus serine/threonine protein kinase 0.0201 0.0785 0.0785
Brugia malayi Temporarily assigned gene name protein 59 0.013 0.0328 0.04
Loa Loa (eye worm) hypothetical protein 0.0087 0.0047 0.0057
Loa Loa (eye worm) hypothetical protein 0.0147 0.0438 0.0534
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0166 0.0558 0.0682
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0113 0.0215 0.0215
Trichomonas vaginalis CMGC family protein kinase 0.0328 0.1612 0.801
Echinococcus granulosus serine:threonine protein kinase N2 0.0131 0.0332 0.0332
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.0944 0.1153
Loa Loa (eye worm) SH2 domain-containing protein 0.0087 0.0047 0.0057
Echinococcus granulosus signal transduction protein lnk realted 0.0087 0.0047 0.0047
Schistosoma mansoni tyrosine kinase 0.0331 0.1631 0.1991
Loa Loa (eye worm) hypothetical protein 0.0293 0.1385 0.1691
Loa Loa (eye worm) hypothetical protein 0.014 0.0391 0.0478
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0234 0.1 0.1
Onchocerca volvulus 0.0189 0.0713 0.2161
Loa Loa (eye worm) SRC-1 0.0297 0.1409 0.172
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0205 0.088
Loa Loa (eye worm) protein kinase domain-containing protein 0.0225 0.0944 0.1153
Schistosoma mansoni tyrosine kinase 0.0849 0.4986 0.6088
Schistosoma mansoni pyruvate dehydrogenase 0.0117 0.0243 0.0296
Brugia malayi RhoGAP domain containing protein 0.0135 0.0361 0.0441
Trichomonas vaginalis cyclin D, putative 0.015 0.0456 0.2148
Echinococcus granulosus SH2 motif 0.0087 0.0047 0.0047
Trypanosoma cruzi cyclin, putative 0.0247 0.1083 0.4519
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0112 0.021 0.0952
Schistosoma mansoni tyrosine kinase 0.0927 0.5491 0.6705
Echinococcus multilocularis 0.0475 0.2561 0.3127
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0431 0.0526
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0156 0.0497 0.0607
Brugia malayi phosphoinositide-dependent protein kinase I 0.0092 0.0084 0.0102
Echinococcus multilocularis neuroglian 0.0153 0.048 0.0586
Brugia malayi Protein kinase domain containing protein 0.0156 0.0496 0.0605
Brugia malayi serine/threonine protein kinase 6 0.0217 0.0889 0.1085
Echinococcus granulosus protein kinase 0.0165 0.0552 0.0552
Plasmodium falciparum serine/threonine protein kinase, putative 0.0217 0.0889 0.983
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0372 0.1893 0.2312
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0217 0.0889 0.1085
Schistosoma mansoni nck2/grb4 0.0139 0.0385 0.047
Brugia malayi Protein kinase domain containing protein 0.0156 0.0496 0.0605
Trichomonas vaginalis cyclin D, putative 0.015 0.0456 0.2148
Trichomonas vaginalis cyclins, putative 0.0247 0.1083 0.5329
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0087 0.0047 0.0057
Echinococcus multilocularis cyclin dependent kinase 0.0219 0.0903 0.1103
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0126 0.0303 0.0303
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0136 0.0525
Echinococcus granulosus casein kinase I delta 0.012 0.0261 0.0261
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0147 0.0439 0.1574
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.009 0.0069 0.0085
Schistosoma mansoni SH2A 0.0087 0.0047 0.0057
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0156 0.0498 0.0608
Loa Loa (eye worm) hypothetical protein 0.0087 0.0047 0.0057
Onchocerca volvulus 0.0087 0.0047 0.0142
Schistosoma mansoni serine/threonine protein kinase 0.043 0.2272 0.2774
Echinococcus granulosus tyrosine protein kinase Srms 0.0567 0.3159 0.3159
Echinococcus granulosus tyrosine protein kinase shark 0.0813 0.4753 0.4753
Brugia malayi cytokine inducible SH2-containing protein 5 0.0087 0.0047 0.0057
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0189 0.0713 0.7814
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0166 0.0558 0.212
Trypanosoma cruzi cyclin 6, putative 0.0247 0.1083 0.4519
Echinococcus multilocularis cyclin dependent kinase 5 0.0219 0.0903 0.1103
Loa Loa (eye worm) hypothetical protein 0.0129 0.0324 0.0395
Giardia lamblia Kinase, CMGC GSK 0.0189 0.0713 0.333
Loa Loa (eye worm) hypothetical protein 0.0113 0.0215 0.0262
Echinococcus granulosus tyrosine kinase 0.0245 0.107 0.107
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0386 0.1987 0.2426
Echinococcus multilocularis nervana 2 0.0146 0.0431 0.0526
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0111 0.0205 0.0251
Echinococcus multilocularis c src tyrosine kinase 0.0208 0.0834 0.1019
Trypanosoma brucei protein kinase, putative 0.0155 0.0492 0.1817
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0219 0.0903 0.1103
Echinococcus multilocularis tensin 0.0087 0.0047 0.0057
Trichomonas vaginalis cyclin B, putative 0.0247 0.1083 0.5329
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0269 0.1229 0.1501
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0303 0.1376
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0082 0.0014 0.0014
Schistosoma mansoni protein kinase 0.0217 0.0889 0.1085
Loa Loa (eye worm) TK/EPH protein kinase 0.0151 0.0467 0.057
Echinococcus granulosus cyclins 0.015 0.0456 0.0456
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0236 0.1014 0.1238
Onchocerca volvulus Serine\/threonine kinase homolog 0.0176 0.0623 0.189
Echinococcus granulosus SHC transforming protein 3 0.0087 0.0047 0.0047
Echinococcus granulosus cyclin dependent kinase 9 0.0098 0.0122 0.0122
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0089 0.0061 0.0061
Echinococcus multilocularis protein kinase shaggy 0.0189 0.0713 0.087
Onchocerca volvulus 0.0087 0.0047 0.0142
Echinococcus multilocularis cyclins 0.015 0.0456 0.0556
Schistosoma mansoni serine/threonine protein kinase 0.0317 0.1539 0.1879
Trypanosoma cruzi casein kinase, putative 0.012 0.0261 0.0763
Schistosoma mansoni serine/threonine protein kinase 0.0338 0.1675 0.2045
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.0205 0.088
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0236 0.1014 0.1239
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0147 0.0441 0.469
Entamoeba histolytica cyclin, putative 0.015 0.0456 0.2259
Echinococcus granulosus hypothetical protein 0.0087 0.0047 0.0047
Echinococcus granulosus serine:threonine protein kinase 0.0084 0.0032 0.0032
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0092 0.0084 0.0102
Echinococcus multilocularis NCK adaptor protein 0.0141 0.0398 0.0486
Brugia malayi SH2 domain containing protein 0.0087 0.0047 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.0498 0.0608
Trichomonas vaginalis AGC family protein kinase 0.0092 0.0084 0.0263
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0146 0.0431 0.0526
Echinococcus multilocularis N chimaerin 0.0135 0.0361 0.0441
Echinococcus multilocularis Glutaredoxin protein 5 0.0146 0.0431 0.0526
Echinococcus granulosus neuroglian 0.0153 0.048 0.048
Schistosoma mansoni serine/threonine protein kinase 0.0253 0.1127 0.1376
Trypanosoma brucei cdc2-related kinase 1 0.0219 0.0903 0.3696

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 8 nM Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as cortisol level after 150 mins by HTRF assay ChEMBL. 19395260

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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