Detailed information for compound 1063468

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 444.542 | Formula: C27H24O4S
  • H donors: 0 H acceptors: 1 LogP: 5.54 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1OC2(CCCCC2)CC2=C1C1OC(O2)(Cc2c1ccc1c2cccc1)c1ccsc1
  • InChi: 1S/C27H24O4S/c28-25-23-22(15-26(31-25)11-4-1-5-12-26)29-27(18-10-13-32-16-18)14-21-19-7-3-2-6-17(19)8-9-20(21)24(23)30-27/h2-3,6-10,13,16,24H,1,4-5,11-12,14-15H2
  • InChiKey: MQUHPJPRVXVQON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae Probable lipase LipE 0.0113 0.0567 0.444
Mycobacterium leprae PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE 0.0018 0.0023 0.0105
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0043 0.0166 0.0178
Echinococcus granulosus fatty acid amide hydrolase 1 0.1648 0.9277 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0043 0.0166 0.0178
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0196 0.0196
Onchocerca volvulus 0.0043 0.0166 0.0356
Trypanosoma cruzi amidase, putative 0.0199 0.1051 0.5252
Echinococcus granulosus serotonin receptor 0.0043 0.0166 0.0178
Schistosoma mansoni alpha-1 adrenergic receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0043 0.0166 0.0178
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0455 0.0491
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0196 0.0212
Schistosoma mansoni notch 0.0046 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Onchocerca volvulus 0.0043 0.0166 0.0356
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0714 0.077
Loa Loa (eye worm) aldehyde dehydrogenase 0.0018 0.0023 0.0024
Brugia malayi Thioredoxin reductase 0.0093 0.0452 0.0487
Mycobacterium tuberculosis Probable lipase LipD 0.0113 0.0567 0.1384
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Echinococcus granulosus neuropeptides capa receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0788 0.4395 0.4738
Onchocerca volvulus 0.0052 0.0218 0.0475
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0033 0.043
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0143 0.1283
Loa Loa (eye worm) hypothetical protein 0.004 0.0148 0.016
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0325 0.566
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0043 0.0166 0.0178
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0196 0.0212
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0236 0.1264 0.3117
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0213 0.113 0.2783
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Schistosoma mansoni peroxidasin 0.0788 0.4395 0.4738
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Mycobacterium tuberculosis Probable hydrolase 0.0113 0.0567 0.1384
Echinococcus granulosus fmrfamide receptor 0.0043 0.0166 0.0178
Entamoeba histolytica hypothetical protein 0.0111 0.0551 0.4764
Toxoplasma gondii hypothetical protein 0.0081 0.0385 0.2177
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0018 0.0023 0.0066
Schistosoma mansoni chromobox protein 0.0071 0.0325 0.035
Onchocerca volvulus 0.0046 0.0184 0.0397
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0113 0.0567 0.0611
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0015 0.0027
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0043 0.0166 0.0178
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.1993 1
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0081 0.0385 0.0415
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0567 0.0611
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0166 0.0166
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0216 0.1146 1
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0023 0.0024
Brugia malayi Serotonin receptor 0.0556 0.308 0.332
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0033 0.043
Loa Loa (eye worm) hypothetical protein 0.0788 0.4395 0.4738
Onchocerca volvulus 0.0081 0.0385 0.0856
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0218 0.1659
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0218 0.1659
Loa Loa (eye worm) hypothetical protein 0.0027 0.0075 0.0081
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0081 0.0385 0.0415
Onchocerca volvulus Chorion peroxidase homolog 0.0788 0.4395 1
Toxoplasma gondii ABC1 family protein 0.0113 0.0567 0.3229
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0018 0.0023 0.0076
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0214 0.1031
Echinococcus granulosus protein jagged 1 0.0046 0.0184 0.0198
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0043 0.0166 0.0178
Toxoplasma gondii thioredoxin reductase 0.0093 0.0452 0.2565
Brugia malayi chromobox protein homolog 3 0.004 0.0148 0.016
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0199 0.1051 1
Loa Loa (eye worm) norepinephrine transporter 0.048 0.2645 0.2851
Echinococcus granulosus intermediate filament protein 0.0058 0.025 0.0269
Schistosoma mansoni sodium-dependent amino acid transporter 0.0081 0.0385 0.0415
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0081 0.0385 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0148 0.2491
Schistosoma mansoni slit 0.0046 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0765 0.4265 0.4598
Brugia malayi putative amidase 0.0199 0.1051 0.1133
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0106 0.0106
Onchocerca volvulus 0.0788 0.4395 1
Mycobacterium ulcerans beta-lactamase 0.0113 0.0567 0.3229
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0319 0.1735 0.8697
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0018 0.0023 0.0024
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0106 0.0929
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Mycobacterium ulcerans aldehyde dehydrogenase 0.0319 0.1735 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0043 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0052 0.0218 0.0235
Loa Loa (eye worm) hypothetical protein 0.0104 0.0514 0.0554
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0385 0.3605
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0018 0.0023 0.0076
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0018 0.0023 0.0076
Schistosoma mansoni septate junction protein 0.0046 0.0184 0.0198
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0143 0.0775
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0106 0.0561
Echinococcus granulosus sodium and chloride dependent glycine 0.0081 0.0385 0.0415
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0018 0.0023 0.0033
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0199 0.1051 0.1051
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0018 0.0023 0.0066
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0018 0.0023 0.0076
Echinococcus multilocularis microtubule associated protein 2 0.0779 0.4345 0.4345
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0166 0.0178
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0018 0.0023 0.0076
Echinococcus granulosus geminin 0.0525 0.2904 0.313
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0106 0.1739
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0199 0.1051 0.2588
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0199 0.1051 0.2588
Brugia malayi putative neuropeptide receptor NPR1 0.0043 0.0166 0.0178
Echinococcus multilocularis neuropeptide Y receptor 0.0043 0.0166 0.0166
Brugia malayi EGF-like domain containing protein 0.0046 0.0184 0.0198
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0018 0.0023 0.0033
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0218 0.0235
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0214 0.1031
Brugia malayi G-protein coupled receptor 0.0043 0.0166 0.0178
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0236 0.1264 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0043 0.0166 0.0178
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0081 0.0385 0.0415
Echinococcus multilocularis conserved hypothetical protein 0.077 0.4295 0.4295
Brugia malayi Aldehyde dehydrogenase protein 4 0.0018 0.0023 0.0024
Schistosoma mansoni growth hormone secretagogue receptor 0.0043 0.0166 0.0178
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0214 0.1031
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0551 0.0594
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Mycobacterium ulcerans peptide amidase, GatA 0.0199 0.1051 0.6039
Entamoeba histolytica hypothetical protein 0.0111 0.0551 0.4764
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0106 0.0813
Onchocerca volvulus 0.0113 0.0567 0.127
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Loa Loa (eye worm) animal heme peroxidase 0.0788 0.4395 0.4738
Schistosoma mansoni biogenic amine (5HT) receptor 0.0463 0.255 0.2749
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0081 0.0385 0.0415
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0199 0.1051 0.1051
Loa Loa (eye worm) animal heme peroxidase 0.0788 0.4395 0.4738
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0143 0.1283
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0903 0.4503
Brugia malayi Muscle positioning protein 4 0.0046 0.0184 0.0198
Brugia malayi hypothetical protein 0.0043 0.0166 0.0178
Echinococcus multilocularis neural cadherin 0.0046 0.0184 0.0184
Schistosoma mansoni cpg binding protein 0.0037 0.0131 0.0141
Brugia malayi Dopamine receptor 0.0043 0.0166 0.0178
Brugia malayi hypothetical protein 0.0087 0.0419 0.0452
Plasmodium vivax glutathione reductase, putative 0.0093 0.0452 0.4247
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0191 0.174
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0106 0.0488
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0106 0.0488
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0098 0.0106
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0018 0.0023 0.0033
Plasmodium falciparum glutathione reductase 0.0032 0.0106 0.0929
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0081 0.0385 0.2177
Loa Loa (eye worm) hypothetical protein 0.0039 0.0143 0.0154
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0106 0.0488
Schistosoma mansoni myosin xvIII 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0039 0.0143 0.0154
Onchocerca volvulus 0.0081 0.0385 0.0856
Echinococcus granulosus sex peptide receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Onchocerca volvulus 0.0043 0.0166 0.0356
Brugia malayi CHE-14 protein 0.0093 0.0448 0.0483
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0081 0.0087
Mycobacterium leprae PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD 0.0018 0.0023 0.0105
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0106 0.0929
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0043 0.0166 0.0356
Schistosoma mansoni hypothetical protein 0.0111 0.0551 0.0594
Echinococcus granulosus 7TM GPCR rhodopsin 0.0043 0.0166 0.0178
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0018 0.0023 0.0033
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0166 0.0178
Echinococcus multilocularis neuropeptide s receptor 0.0043 0.0166 0.0166
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0018 0.0023 0.0066
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0319 0.1735 0.1735
Echinococcus multilocularis somatostatin receptor 0.0043 0.0166 0.0166
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0106 0.0488
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0106 0.0488
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Onchocerca volvulus 0.0043 0.0166 0.0356
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0018 0.0023 0.0066
Loa Loa (eye worm) hypothetical protein 0.048 0.2645 0.2851
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0018 0.0023 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0166 0.0166
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0018 0.0023 0.0066
Schistosoma mansoni hypothetical protein 0.0018 0.0023 0.0024
Brugia malayi Amidase family protein 0.0199 0.1051 0.1133
Onchocerca volvulus 0.0043 0.0166 0.0356
Echinococcus multilocularis protein jagged 1 0.0046 0.0184 0.0184
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0018 0.0023 0.0238
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0166 0.0178
Mycobacterium tuberculosis Conserved protein 0.0113 0.0567 0.1384
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0081 0.0385 0.0415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0166 0.0178
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0018 0.0023 0.003
Echinococcus granulosus peroxidasin 0.0788 0.4395 0.4738
Onchocerca volvulus 0.0043 0.0166 0.0356
Loa Loa (eye worm) hypothetical protein 0.0124 0.0629 0.0678
Schistosoma mansoni cpg binding protein 0.0037 0.0131 0.0141
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Onchocerca volvulus 0.0788 0.4395 1
Schistosoma mansoni opsin-like receptor 0.0043 0.0166 0.0178
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0165 0.2798
Loa Loa (eye worm) hypothetical protein 0.0113 0.0567 0.0611
Loa Loa (eye worm) hypothetical protein 0.0179 0.0937 0.101
Echinococcus multilocularis g-protein coupled receptor 0.0043 0.0166 0.0166
Brugia malayi aldehyde dehydrogenase 0.0018 0.0023 0.0024
Echinococcus granulosus lamin dm0 0.0058 0.025 0.0269
Loa Loa (eye worm) animal heme peroxidase 0.0788 0.4395 0.4738
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Brugia malayi GnHR receptor homolog 0.0043 0.0166 0.0178
Brugia malayi follicle stimulating hormone receptor 0.0043 0.0166 0.0178
Echinococcus multilocularis Niemann Pick C1 protein 0.0308 0.1672 0.1672
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Brugia malayi hypothetical protein 0.0043 0.0166 0.0178
Echinococcus multilocularis g protein coupled receptor 0.0043 0.0166 0.0166
Schistosoma mansoni fatty-acid amide hydrolase 0.0199 0.1051 0.1133
Schistosoma mansoni opsin-like receptor 0.0043 0.0166 0.0178
Toxoplasma gondii hypothetical protein 0.0059 0.0257 0.1434
Echinococcus multilocularis protein patched 0.0093 0.0448 0.0448
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0081 0.0385 0.0385
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.0166 0.0178
Schistosoma mansoni amine GPCR 0.0043 0.0166 0.0178
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0916 0.0988
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0018 0.0023 0.0116
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0218 0.1049
Echinococcus multilocularis slit 2 protein 0.0046 0.0184 0.0184
Brugia malayi G-protein coupled receptor 0.0043 0.0166 0.0178
Echinococcus granulosus neuropeptide FF receptor 2 0.0043 0.0166 0.0178
Onchocerca volvulus 0.0043 0.0166 0.0356
Echinococcus granulosus neuropeptide Y receptor 0.0043 0.0166 0.0178
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0106 0.0488
Echinococcus granulosus fatty acid amide hydrolase 1 0.0199 0.1051 0.1133
Brugia malayi Calcium binding EGF domain containing protein 0.0046 0.0184 0.0198
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0043 0.0166 0.0166
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0215 0.0232
Brugia malayi Animal haem peroxidase family protein 0.0788 0.4395 0.4738
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0166 0.0178
Brugia malayi Animal haem peroxidase family protein 0.0788 0.4395 0.4738
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0043 0.0166 0.0178
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0046 0.0184 0.0198
Brugia malayi hypothetical protein 0.0081 0.0385 0.0415
Schistosoma mansoni hypothetical protein 0.0525 0.2904 0.313
Onchocerca volvulus Neurogenic locus notch homolog 0.0046 0.0184 0.0397
Echinococcus granulosus g protein coupled receptor 0.0043 0.0166 0.0178
Brugia malayi AMP-binding enzyme family protein 0.0015 0.001 0.001
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0018 0.0023 0.0076
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0043 0.0166 0.0178
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0199 0.1051 0.2588
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0015 0.0027
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0165 0.0355
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0043 0.0166 0.0178
Brugia malayi ORL1-like opioid receptor 0.0043 0.0166 0.0178
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0215 0.1974
Brugia malayi Calcium binding EGF domain containing protein 0.0046 0.0184 0.0198
Brugia malayi MH2 domain containing protein 0.0142 0.0728 0.0785
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0166 0.0166
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0043 0.0166 0.0178
Echinococcus multilocularis neuropeptide receptor A26 0.0043 0.0166 0.0166
Loa Loa (eye worm) acetyltransferase 0.0175 0.0916 0.0988
Echinococcus multilocularis neurogenic locus notch protein 4 0.0046 0.0184 0.0184
Onchocerca volvulus Huntingtin homolog 0.0124 0.0629 0.1413
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0213 0.113 0.8927
Onchocerca volvulus Peroxidase homolog 0.0788 0.4395 1
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0199 0.1051 1
Loa Loa (eye worm) serotonin transporter b 0.048 0.2645 0.2851
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Onchocerca volvulus 0.0113 0.0567 0.127
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0156 0.0809 0.0872
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0057 0.0244 0.0263
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0081 0.0385 0.295
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0093 0.0448 0.0483
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0106 0.0488
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0196 0.0196
Echinococcus multilocularis neuropeptide receptor 0.0043 0.0166 0.0166
Schistosoma mansoni histamine h1 receptor 0.0043 0.0166 0.0178
Onchocerca volvulus 0.0043 0.0166 0.0356
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.0166 0.0178
Schistosoma mansoni aldehyde dehydrogenase 0.0319 0.1735 0.187
Schistosoma mansoni hypothetical protein 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0013 0.0059
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0015 0.0016
Onchocerca volvulus Neuropeptide F receptor homolog 0.0043 0.0166 0.0356
Brugia malayi CXXC zinc finger family protein 0.0035 0.012 0.0129
Brugia malayi RE15519p 0.0043 0.0166 0.0178
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0889 0.0958
Mycobacterium ulcerans lipase LipD 0.0113 0.0567 0.3229
Echinococcus granulosus GPCR family 2 0.0048 0.0196 0.0212
Schistosoma mansoni cell polarity protein 0.0046 0.0184 0.0198
Schistosoma mansoni hypothetical protein 0.0525 0.2904 0.313
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0043 0.0166 0.0178
Entamoeba histolytica hypothetical protein 0.0111 0.0551 0.4764
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0551 0.0594
Echinococcus granulosus g-protein coupled receptor 0.0043 0.0166 0.0178
Schistosoma mansoni hypothetical protein 0.0089 0.0429 0.0463
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0081 0.0385 0.0415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0166 0.0178
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Schistosoma mansoni hypothetical protein 0.0494 0.2727 0.2939
Echinococcus multilocularis neuropeptide Y receptor 0.0043 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0788 0.4395 0.4738
Echinococcus multilocularis sterol regulatory element binding protein 0.0093 0.0448 0.0448
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0714 0.077
Loa Loa (eye worm) hypothetical protein 0.0788 0.4395 0.4738
Onchocerca volvulus Peroxidasin homolog 0.0788 0.4395 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0143 0.0154
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0567 1
Loa Loa (eye worm) neuropeptide F receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0903 0.4503
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0131 0.0302
Schistosoma mansoni sodium/chloride dependent transporter 0.048 0.2645 0.2851
Onchocerca volvulus 0.0046 0.0184 0.0397
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0106 0.0488
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0567 1
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2727 0.2939
Schistosoma mansoni notch 0.0046 0.0184 0.0198
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0018 0.0023 0.0024
Echinococcus granulosus protein jagged 1 0.0046 0.0184 0.0198
Echinococcus granulosus neuropeptide receptor A26 0.0043 0.0166 0.0178
Leishmania major hypothetical protein, conserved 0.0113 0.0567 0.2808
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.025 0.0269
Mycobacterium ulcerans hypothetical protein 0.0113 0.0567 0.3229
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0724 0.4035 1
Schistosoma mansoni hypothetical protein 0.0046 0.0184 0.0198
Echinococcus granulosus G protein coupled receptor 139 0.0043 0.0166 0.0178
Echinococcus multilocularis fmrfamide receptor 0.0043 0.0166 0.0166
Leishmania major aldehyde dehydrogenase, putative 0.0018 0.0023 0.0066
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0023 0.0066
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0098 0.0106
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0199 0.1051 0.1133
Toxoplasma gondii EGF family domain-containing protein 0.0046 0.0184 0.101
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0714 0.077
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0106 0.0488
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1648 0.9277 0.9277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0166 0.0178
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0023 0.0066
Loa Loa (eye worm) hypothetical protein 0.0179 0.0937 0.101
Giardia lamblia High cysteine protein 0.0046 0.0184 0.9584
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0166 0.0178
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0033 0.043
Loa Loa (eye worm) hypothetical protein 0.0031 0.01 0.0107
Echinococcus granulosus neuropeptides capa receptor 0.0043 0.0166 0.0178
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0018 0.0023 0.0066
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0106 0.0561
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0015 0.0013
Onchocerca volvulus 0.0046 0.0184 0.0397
Echinococcus granulosus biogenic amine 5HT receptor 0.0463 0.255 0.2749
Echinococcus granulosus alpha 1A adrenergic receptor 0.0043 0.0166 0.0178
Schistosoma mansoni lamin 0.0058 0.025 0.0269
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.0452 0.1099
Schistosoma mansoni patched 1 0.0093 0.0448 0.0483
Echinococcus multilocularis neurogenic locus notch protein 0.0046 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0043 0.0166 0.0178
Brugia malayi Cadherin domain containing protein 0.0046 0.0184 0.0198
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0218 0.0235
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0199 0.1051 0.2588
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0113 0.0567 0.0611
Trypanosoma brucei trypanothione reductase 0.0093 0.0452 0.223
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.1993 1
Echinococcus granulosus protein jagged 2 0.0046 0.0184 0.0198
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0079 0.0666
Loa Loa (eye worm) hypothetical protein 0.0788 0.4395 0.4738
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.0166 0.0178
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0018 0.0023 0.0024
Mycobacterium ulcerans amidase 0.0199 0.1051 0.6039
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0081 0.0385 0.0415
Onchocerca volvulus 0.0043 0.0166 0.0356
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0787 0.0848
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.0218 0.183
Onchocerca volvulus Huntingtin homolog 0.0124 0.0629 0.1413
Schistosoma mansoni hypothetical protein 0.0046 0.0184 0.0198
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0043 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0081 0.0385 0.0415
Schistosoma mansoni notch 0.0046 0.0184 0.0198
Brugia malayi hypothetical protein 0.0043 0.0166 0.0178
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0199 0.1051 0.6039
Brugia malayi hypothetical protein 0.0765 0.4265 0.4598
Echinococcus multilocularis orexin receptor type 2 0.0043 0.0166 0.0166
Schistosoma mansoni hypothetical protein 0.0089 0.0429 0.0463
Brugia malayi hypothetical protein 0.0043 0.0166 0.0178
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0714 0.0714
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0018 0.0023 0.0024
Brugia malayi Tachykinin-like peptides receptor 99D 0.0043 0.0166 0.0178
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0081 0.0385 0.0415
Schistosoma mansoni amidase 0.1648 0.9277 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0218 0.1206
Echinococcus multilocularis G protein coupled receptor 139 0.0043 0.0166 0.0166
Echinococcus multilocularis sodium and chloride dependent glycine 0.0081 0.0385 0.0385
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0015 0.0027
Echinococcus granulosus neurogenic locus notch protein 0.0046 0.0184 0.0198
Loa Loa (eye worm) TYRA-2 protein 0.0043 0.0166 0.0178
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0081 0.0385 0.0415
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0166 0.0178
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.032 0.1801
Loa Loa (eye worm) hypothetical protein 0.0087 0.0419 0.0452
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0018 0.0023 0.0033
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0015 0.0016
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0081 0.0385 0.0385
Echinococcus multilocularis peroxidasin 0.0788 0.4395 0.4395
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0106 0.0115
Mycobacterium tuberculosis Conserved protein 0.0113 0.0567 0.1384
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Echinococcus granulosus 7tm_1 domain containing protein 0.0043 0.0166 0.0178
Mycobacterium ulcerans aldehyde dehydrogenase 0.0018 0.0023 0.0076
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.0452 0.223
Schistosoma mansoni hypothetical protein 0.0046 0.0184 0.0198
Onchocerca volvulus 0.0046 0.0184 0.0397
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0081 0.0385 0.0415
Echinococcus multilocularis tumor protein p63 0.0382 0.2088 0.2088
Schistosoma mansoni hypothetical protein 0.0089 0.0429 0.0463
Loa Loa (eye worm) hypothetical protein 0.0113 0.0567 0.0611
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0916 0.0916
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0714 0.077
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Schistosoma mansoni amine GPCR 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0788 0.4395 0.4738
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0015 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0567 0.2808
Echinococcus multilocularis chromobox protein 1 0.0071 0.0325 0.0325
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0236 0.1264 0.3117
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0018 0.0023 0.0023
Echinococcus multilocularis G-protein coupled receptor, putative 0.0043 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0018 0.0023 0.0023
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0018 0.0023 0.0024
Echinococcus multilocularis lamin dm0 0.0058 0.025 0.025
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0043 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Brugia malayi glutathione reductase 0.0093 0.0452 0.0487
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0043 0.0166 0.0178
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0106 0.0929
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0214 0.1031
Echinococcus multilocularis protein jagged 2 0.0046 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0788 0.4395 0.4738
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0081 0.0385 0.0415
Plasmodium falciparum thioredoxin reductase 0.0032 0.0106 0.0929
Brugia malayi Peroxidasin 0.0788 0.4395 0.4738
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0033 0.043
Echinococcus granulosus chromobox protein 1 0.0071 0.0325 0.035
Plasmodium falciparum transporter, putative 0.0081 0.0385 0.3605
Mycobacterium tuberculosis Probable lipase LipE 0.0113 0.0567 0.1384
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0567 1
Echinococcus granulosus expressed conserved protein 0.0202 0.1072 0.1156
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0018 0.0023 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0567 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0015 0.0051
Echinococcus multilocularis serotonin receptor 0.0179 0.0937 0.0937
Echinococcus granulosus cpg binding protein 0.0037 0.0131 0.0141
Echinococcus granulosus beta LACTamase domain containing family member 0.0113 0.0567 0.0611
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0788 0.4395 0.4738
Mycobacterium ulcerans hypothetical protein 0.0192 0.1013 0.5819
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0018 0.0023 0.0116
Echinococcus multilocularis g protein coupled receptor 0.0043 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0039 0.0143 0.0154
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0058 0.0062
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.001 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0551 0.0551
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0058 0.025 0.0269
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0218 0.183
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0046 0.0184 0.0198
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0514 0.0554
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0079 0.0666
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0018 0.0023 0.0024
Echinococcus granulosus sterol regulatory element binding protein 0.0093 0.0448 0.0483
Brugia malayi AMP-binding enzyme family protein 0.0015 0.001 0.001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0787 0.0848
Echinococcus multilocularis lamin 0.0058 0.025 0.025
Leishmania major hypothetical protein, conserved 0.0199 0.1051 0.5252
Brugia malayi hypothetical protein 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Brugia malayi Niemann-Pick C1 protein precursor 0.0216 0.1146 0.1236
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0018 0.0023 0.0066
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0018 0.0023 0.0076
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.0452 0.4247
Loa Loa (eye worm) hypothetical protein 0.0113 0.0566 0.061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0166 0.0178
Schistosoma mansoni amine GPCR 0.0043 0.0166 0.0178
Schistosoma mansoni hypothetical protein 0.0046 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0081 0.0385 0.0415
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0106 0.4973
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0166 0.0166
Echinococcus multilocularis neuropeptides capa receptor 0.0043 0.0166 0.0166
Treponema pallidum NADH oxidase 0.0032 0.0106 0.0319
Echinococcus granulosus neurogenic locus protein delta 0.0046 0.0184 0.0198
Echinococcus multilocularis survival motor neuron protein 1 0.0765 0.4265 0.4265
Schistosoma mansoni intermediate filament proteins 0.0058 0.025 0.0269
Mycobacterium ulcerans amidase 0.0199 0.1051 0.6039
Schistosoma mansoni hypothetical protein 0.0048 0.0196 0.0212
Plasmodium falciparum thioredoxin reductase 0.0093 0.0452 0.4247
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0082 0.1311
Schistosoma mansoni aldehyde dehydrogenase 0.0319 0.1735 0.187
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0015 0.0016
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.0452 0.0487
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2727 0.2727
Brugia malayi AMP-binding enzyme family protein 0.0015 0.001 0.001
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0023 0.0066
Echinococcus multilocularis neuropeptides capa receptor 0.0043 0.0166 0.0166
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0106 0.1739
Loa Loa (eye worm) hypothetical protein 0.0216 0.1146 0.1236
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0015 0.0015
Brugia malayi hypothetical protein 0.0027 0.0079 0.0085
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0015 0.0016
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0113 0.0567 0.1384
Onchocerca volvulus 0.0113 0.0567 0.127
Echinococcus multilocularis g protein coupled receptor 0.0043 0.0166 0.0166
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0046 0.0184 0.0397
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0166 0.0178
Schistosoma mansoni opsin-like receptor 0.0043 0.0166 0.0178
Echinococcus multilocularis GPCR, family 2 0.0048 0.0196 0.0196
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0081 0.0385 0.0415
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0567 0.444
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0033 0.043
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0567 0.5348
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0058 0.0062
Brugia malayi Heterochromatin protein 1 0.0071 0.0325 0.035
Brugia malayi hypothetical protein 0.0018 0.0024 0.0026
Onchocerca volvulus 0.0043 0.0166 0.0356
Echinococcus multilocularis neurogenic locus notch protein 0.0046 0.0184 0.0184
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0018 0.0023 0.0076
Echinococcus multilocularis dro:myosuppressin receptor 0.0043 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0788 0.4395 0.4738
Loa Loa (eye worm) G-protein coupled receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0024
Brugia malayi Delta serrate ligand family protein 0.0046 0.0184 0.0198
Brugia malayi Animal haem peroxidase family protein 0.0788 0.4395 0.4738
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.001 0.001
Brugia malayi beta-lactamase 0.0113 0.0567 0.0611
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.0166 0.0178
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0018 0.0023 0.0076
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0018 0.0023 0.0033
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0113 0.0567 0.0611
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0018 0.0023 0.0116
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0714 0.077
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.0567 0.2808
Plasmodium falciparum amino acid transporter, putative 0.0081 0.0385 0.3605
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0043 0.0166 0.0166
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0106 0.0488
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.0218 0.1206
Echinococcus multilocularis protein jagged 1 0.0046 0.0184 0.0184
Onchocerca volvulus 0.0043 0.0166 0.0356
Schistosoma mansoni hypothetical protein 0.0048 0.0196 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0448 0.7872
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.0166 0.0166
Brugia malayi hypothetical protein 0.0124 0.0629 0.0678
Brugia malayi putative neuropeptide receptor 0.0043 0.0166 0.0178
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0106 0.0488
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Brugia malayi beta-lactamase family protein 0.0113 0.0567 0.0611
Loa Loa (eye worm) hypothetical protein 0.0048 0.0196 0.0212
Loa Loa (eye worm) hypothetical protein 0.1648 0.9277 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0081 0.0385 0.0385
Schistosoma mansoni neuropeptide receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0199 0.1051 0.8303
Echinococcus multilocularis neuropeptide receptor 0.0043 0.0166 0.0166
Brugia malayi Sodium:neurotransmitter symporter family protein 0.048 0.2645 0.2851
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0079 0.0402
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0106 0.0813
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0341 0.0367
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0166 0.0166
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0015 0.0027
Loa Loa (eye worm) intermediate filament protein 0.0058 0.025 0.0269
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Trichomonas vaginalis esterase, putative 0.0113 0.0567 1
Onchocerca volvulus Dual oxidase homolog 0.0788 0.4395 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0166 0.0166
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0218 0.1049
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0023 0.0066
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0018 0.0023 0.0033
Echinococcus multilocularis neurogenic locus protein delta 0.0046 0.0184 0.0184
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0199 0.1051 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0018 0.0023 0.0076
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0463 0.255 0.255
Mycobacterium ulcerans aldehyde dehydrogenase 0.0319 0.1735 1
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0325 0.566
Onchocerca volvulus 0.0788 0.4395 1
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0018 0.0023 0.0076
Schistosoma mansoni amine GPCR 0.0043 0.0166 0.0178
Brugia malayi Animal haem peroxidase family protein 0.0788 0.4395 0.4738
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0319 0.1735 0.187
Toxoplasma gondii hypothetical protein 0.0081 0.0385 0.2177
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0018 0.0023 0.0033
Trypanosoma cruzi amidase, putative 0.0199 0.1051 0.5252
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0113 0.0567 0.0611
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0018 0.0023 0.0066
Echinococcus granulosus neuropeptide Y receptor 0.0043 0.0166 0.0178
Echinococcus granulosus dro:myosuppressin receptor 0.0043 0.0166 0.0178
Mycobacterium ulcerans amidase 0.0199 0.1051 0.6039
Brugia malayi neuropeptide F receptor 0.0043 0.0166 0.0178
Schistosoma mansoni biogenic amine receptor 0.0043 0.0166 0.0178
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0043 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Schistosoma mansoni adenoreceptor 0.0043 0.0166 0.0178
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0916 0.0988
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0018 0.0023 0.0076
Brugia malayi hypothetical protein 0.0043 0.0166 0.0178
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0113 0.0567 0.0611
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0023 0.0024
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0018 0.0023 0.0076
Brugia malayi hypothetical protein 0.0788 0.4395 0.4738
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0079 0.035
Echinococcus granulosus slit 2 protein 0.0046 0.0184 0.0198
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0131 0.0302
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0106 0.0929
Schistosoma mansoni biogenic amine receptor 0.0043 0.0166 0.0178
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0113 0.0567 0.1384
Echinococcus granulosus neurogenic locus notch protein 0.0046 0.0184 0.0198
Entamoeba histolytica hypothetical protein 0.0111 0.0551 0.4764
Schistosoma mansoni microtubule-associated protein tau 0.0779 0.4345 0.4684
Brugia malayi Blistered cuticle protein 3 0.0788 0.4395 0.4738
Echinococcus granulosus g protein coupled receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Plasmodium vivax amine transporter, putative 0.0081 0.0385 0.3605
Brugia malayi Amidase family protein 0.0199 0.1051 0.1133
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0191 1
Echinococcus granulosus serotonin transporter 0.048 0.2645 0.2851
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0278 0.1352
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0213 0.113 0.2783
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0043 0.0166 0.0166
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0018 0.0023 0.0066
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0081 0.0385 0.0385
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1993 1
Brugia malayi hypothetical protein 0.0043 0.0166 0.0178
Loa Loa (eye worm) amidase 0.0199 0.1051 0.1133
Loa Loa (eye worm) hypothetical protein 0.048 0.2645 0.2851
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0082 0.1311
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0043 0.0166 0.0178
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0023 0.0024
Echinococcus granulosus biogenic amine 5HT receptor 0.0179 0.0937 0.101
Schistosoma mansoni hypothetical protein 0.0104 0.0514 0.0554
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0043 0.0166 0.0178
Brugia malayi EGF-like domain containing protein 0.0046 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Treponema pallidum sodium- and chloride- dependent transporter 0.048 0.2645 1
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.001 0.001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0196 0.0212
Loa Loa (eye worm) hypothetical protein 0.0081 0.0385 0.0415
Loa Loa (eye worm) hypothetical protein 0.0081 0.0385 0.0415
Onchocerca volvulus 0.0156 0.0809 0.1822
Onchocerca volvulus 0.0058 0.025 0.0548
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0319 0.1735 0.4286
Echinococcus granulosus allatostatin A receptor 0.0043 0.0166 0.0178
Mycobacterium tuberculosis Conserved protein 0.0113 0.0567 0.1384
Schistosoma mansoni hypothetical protein 0.0048 0.0196 0.0212
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.0218 0.1206
Mycobacterium tuberculosis Probable dehydrogenase 0.0213 0.113 0.2783
Loa Loa (eye worm) hypothetical protein 0.0052 0.0218 0.0235
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0218 0.1206
Brugia malayi intermediate filament protein 0.0058 0.025 0.0269
Loa Loa (eye worm) animal heme peroxidase 0.0788 0.4395 0.4738
Echinococcus granulosus Niemann Pick C1 protein 0.0308 0.1672 0.1802
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0018 0.0023 0.0066
Echinococcus multilocularis allatostatin A receptor 0.0043 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0039 0.0143 0.0154
Schistosoma mansoni hypothetical protein 0.0046 0.0184 0.0198
Onchocerca volvulus 0.0043 0.0166 0.0356
Schistosoma mansoni hypothetical protein 0.0043 0.0166 0.0178
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.001 0.001
Onchocerca volvulus 0.0043 0.0166 0.0356
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0218 0.0235
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0081 0.0385 0.2177
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0714 0.0714
Echinococcus multilocularis musashi 0.0058 0.025 0.025
Brugia malayi larval opioid receptor 0.0043 0.0166 0.0178
Mycobacterium tuberculosis Probable reductase 0.0213 0.113 0.2783
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0199 0.1051 0.2588
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0081 0.0385 0.0415
Brugia malayi EGF-like domain containing protein 0.0046 0.0184 0.0198
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0018 0.0023 0.0076
Brugia malayi neuropeptide F receptor 0.0043 0.0166 0.0178
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.0218 0.0517
Onchocerca volvulus 0.0046 0.0184 0.0397
Echinococcus granulosus neuropeptide receptor 0.0043 0.0166 0.0178
Onchocerca volvulus 0.0043 0.0166 0.0356
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0199 0.1051 0.3923
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0043 0.0166 0.0166
Mycobacterium leprae PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT 0.0018 0.0023 0.0105
Echinococcus granulosus lamin 0.0058 0.025 0.0269
Echinococcus granulosus somatostatin receptor 0.0043 0.0166 0.0178
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0015 0.0015
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0218 0.183
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0106 0.0488
Mycobacterium ulcerans esterase/lipase LipP 0.0113 0.0567 0.3229
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0033 0.043
Brugia malayi beta-lactamase family protein 0.0113 0.0567 0.0611
Loa Loa (eye worm) MH2 domain-containing protein 0.0142 0.0728 0.0785
Onchocerca volvulus Peroxidase homolog 0.0788 0.4395 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0385 0.0415
Onchocerca volvulus Putative cubilin 0.0046 0.0184 0.0397
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0018 0.0023 0.0024
Schistosoma mansoni lamin 0.0058 0.025 0.0269
Brugia malayi Animal haem peroxidase family protein 0.0788 0.4395 0.4738
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0148 0.0316
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0015 0.0031
Echinococcus granulosus neural cadherin 0.0046 0.0184 0.0198
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0199 0.1051 0.1133
Brugia malayi Melatonin receptor type 1A 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.048 0.2645 0.2851
Onchocerca volvulus 0.0056 0.024 0.0525
Schistosoma mansoni notch 0.0046 0.0184 0.0198
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0043 0.0166 0.0178
Brugia malayi Serotonin receptor 0.0043 0.0166 0.0178
Mycobacterium ulcerans amidase 0.0199 0.1051 0.6039
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0903 0.4503
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0787 0.0848
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0018 0.0023 0.0066
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0106 0.024
Echinococcus granulosus orexin receptor type 2 0.0043 0.0166 0.0178
Echinococcus granulosus g protein coupled receptor 0.0043 0.0166 0.0178
Schistosoma mansoni hypothetical protein 0.0046 0.0184 0.0198
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0218 0.1049
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0043 0.0166 0.0178
Onchocerca volvulus Peroxidasin homolog 0.0788 0.4395 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0236 0.1264 0.3117
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0018 0.0023 0.0066
Echinococcus granulosus tumor protein p63 0.0382 0.2088 0.2251
Toxoplasma gondii aldehyde dehydrogenase 0.0319 0.1735 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0166 0.0178
Echinococcus multilocularis serotonin transporter 0.048 0.2645 0.2645
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Echinococcus granulosus delta-like protein 1 0.0046 0.0184 0.0198
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0018 0.0023 0.0116
Loa Loa (eye worm) hypothetical protein 0.0081 0.0385 0.0415
Schistosoma mansoni neuropeptide receptor 0.0043 0.0166 0.0178
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0106 0.0561
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0714 0.077
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0199 0.1051 0.8303
Echinococcus multilocularis sex peptide receptor 0.0043 0.0166 0.0166
Echinococcus multilocularis beta LACTamase domain containing family member 0.0113 0.0567 0.0567
Leishmania major trypanothione reductase 0.0093 0.0452 0.223
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0018 0.0023 0.0066
Brugia malayi hypothetical protein 0.0043 0.0166 0.0178
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0079 0.0666
Loa Loa (eye worm) glutathione reductase 0.0093 0.0452 0.0487
Schistosoma mansoni notch 0.0046 0.0184 0.0198
Schistosoma mansoni neuropeptide receptor 0.0043 0.0166 0.0178
Schistosoma mansoni cpg binding protein 0.0035 0.012 0.0129
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.048 0.2645 0.2851
Echinococcus multilocularis notch 0.0046 0.0184 0.0184
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0106 0.0115
Echinococcus granulosus notch 0.0046 0.0184 0.0198
Brugia malayi EGF-like domain containing protein 0.0046 0.0184 0.0198
Brugia malayi Dopamine receptor protein 1 0.0043 0.0166 0.0178
Brugia malayi hypothetical protein 0.0043 0.0166 0.0178
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0113 0.0567 0.3229
Brugia malayi sulfakinin receptor protein 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0087
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0106 0.0488
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0043 0.0166 0.0178
Brugia malayi hypothetical protein 0.0111 0.0551 0.0594
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0015 0.0027
Echinococcus multilocularis cpg binding protein 0.0037 0.0131 0.0131
Echinococcus multilocularis geminin 0.0525 0.2904 0.2904
Loa Loa (eye worm) G-protein coupled receptor 0.0043 0.0166 0.0178
Echinococcus multilocularis fat cadherin tumor suppressor 0.0046 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0056 0.024 0.0259
Brugia malayi EGF-like domain containing protein 0.0046 0.0184 0.0198
Leishmania major aldehyde dehydrogenase, putative 0.0018 0.0023 0.0066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0218 0.0517
Schistosoma mansoni survival motor neuron protein 0.0156 0.0809 0.0872
Echinococcus multilocularis neurogenic locus protein delta 0.0046 0.0184 0.0184
Echinococcus granulosus survival motor neuron protein 1 0.0765 0.4265 0.4598
Onchocerca volvulus 0.0035 0.012 0.0252
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0018 0.0023 0.0033
Leishmania major hypothetical protein, conserved 0.0027 0.0079 0.035
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0015 0.0051
Loa Loa (eye worm) amidase 0.0199 0.1051 0.1133
Leishmania major aldehyde dehydrogenase, putative 0.0018 0.0023 0.0066
Brugia malayi notch-like transmembrane receptor 0.0046 0.0184 0.0198
Loa Loa (eye worm) neuropeptide F receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0788 0.4395 0.4738
Brugia malayi G protein-coupled receptor 0.0043 0.0166 0.0178
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1013 0.2494
Onchocerca volvulus 0.0043 0.0166 0.0356
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0213 0.113 0.2783
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0081 0.0385 0.0415
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0113 0.0567 0.1384
Schistosoma mansoni neuropeptide receptor 0.0043 0.0166 0.0178
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0213 0.113 0.2783
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Schistosoma mansoni eyes absent homolog 0.0087 0.0419 0.0452
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0033 0.043
Plasmodium falciparum glutathione reductase 0.0093 0.0452 0.4247
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0018 0.0023 0.0024
Echinococcus multilocularis chromobox protein 1 0.0071 0.0325 0.0325
Echinococcus granulosus peptide allatostatin:somatostatin 0.0043 0.0166 0.0178
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0567 0.0611
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0143 0.039
Mycobacterium ulcerans amidase 0.0199 0.1051 0.6039
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0079 0.035
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0106 0.0488
Loa Loa (eye worm) hypothetical protein 0.0113 0.0567 0.0611
Brugia malayi AKH receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0788 0.4395 0.4738
Schistosoma mansoni sodium/chloride dependent transporter 0.0081 0.0385 0.0415
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Brugia malayi hypothetical protein 0.0043 0.0166 0.0178
Echinococcus granulosus protein jagged 2 0.0046 0.0184 0.0198
Schistosoma mansoni neuropeptide f receptor 76f 0.0043 0.0166 0.0178
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.0218 0.1206
Schistosoma mansoni laminin gamma-3 chain 0.0046 0.0184 0.0198
Echinococcus granulosus tachykinin peptides receptor 99D 0.0043 0.0166 0.0178
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1993 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0419 0.0452
Mycobacterium tuberculosis Probable esterase LipL 0.0113 0.0567 0.1384
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.0166 0.0166
Brugia malayi GCC2 and GCC3 family protein 0.0046 0.0184 0.0198
Brugia malayi Cadherin domain containing protein 0.0046 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0093 0.0448 0.0483
Echinococcus multilocularis fibropellin Ia 0.0046 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Onchocerca volvulus Slit protein homolog 0.0046 0.0184 0.0397
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.0166 0.0166
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0106 0.0488
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0106 0.0115
Brugia malayi EGF-like domain containing protein 0.0046 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0152 0.0787 0.0848
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0015 0.0015
Onchocerca volvulus 0.0058 0.025 0.0548
Echinococcus granulosus neurogenic locus notch protein 4 0.0046 0.0184 0.0198
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0455 0.0455
Loa Loa (eye worm) oxidoreductase 0.0015 0.001 0.001
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0043 0.0166 0.0166
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.001 0.001
Echinococcus granulosus fibropellin Ia 0.0046 0.0184 0.0198
Loa Loa (eye worm) hypothetical protein 0.0124 0.0629 0.0678
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0567 1
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0018 0.0023 0.0066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0131 0.0302
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0018 0.0023 0.0023
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0106 0.0488
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.024 0.0259
Schistosoma mansoni peroxidasin 0.0788 0.4395 0.4738
Echinococcus multilocularis neuropeptide FF receptor 2 0.0043 0.0166 0.0166
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0106 0.0561
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0013 0.0059
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0018 0.0023 0.0024
Echinococcus granulosus Protein patched homolog 1 0.0093 0.0448 0.0483
Echinococcus granulosus neuropeptide s receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0018 0.0023 0.0023
Mycobacterium ulcerans aldehyde dehydrogenase 0.0319 0.1735 1
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0199 0.1051 0.5252
Loa Loa (eye worm) melatonin receptor type 1A 0.0043 0.0166 0.0178
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0043 0.0166 0.0178
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0218 0.1206
Brugia malayi AMP-binding enzyme family protein 0.0015 0.001 0.001
Brugia malayi amidase 0.1648 0.9277 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Schistosoma mansoni hypothetical protein 0.0156 0.0809 0.0872
Onchocerca volvulus 0.048 0.2645 0.6009
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0148 0.2491
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0191 0.1595
Loa Loa (eye worm) transcription factor SMAD2 0.0142 0.0728 0.0785
Brugia malayi EGF-like domain containing protein 0.0046 0.0184 0.0198
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0081 0.0385 0.0415
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0106 0.0488
Echinococcus granulosus fatty acid amide hydrolase 1 0.1648 0.9277 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.012 0.0129
Loa Loa (eye worm) hypothetical protein 0.0081 0.0385 0.0415
Echinococcus granulosus microtubule associated protein 2 0.0779 0.4345 0.4684
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0018 0.0023 0.0076
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0043 0.0166 0.0178
Schistosoma mansoni hypothetical protein 0.0048 0.0196 0.0212
Brugia malayi isocitrate dehydrogenase 0.0016 0.0015 0.0016
Schistosoma mansoni sodium/chloride dependent transporter 0.0081 0.0385 0.0415
Schistosoma mansoni neuropeptide F-like receptor 0.0043 0.0166 0.0178
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0199 0.1051 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0215 0.3692
Loa Loa (eye worm) beta-lactamase 0.0113 0.0567 0.0611
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0215 0.3692
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0079 0.035
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0166 0.0178
Brugia malayi Dopamine receptor protein 2 0.0043 0.0166 0.0178
Schistosoma mansoni aldehyde dehydrogenase 0.0018 0.0023 0.0024
Onchocerca volvulus 0.0043 0.0166 0.0356
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1648 0.9277 0.9277
Schistosoma mansoni neuropeptide F-like receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) solute carrier family 6 member 4 0.048 0.2645 0.2851
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Schistosoma mansoni fatty-acid amide hydrolase 0.1648 0.9277 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.0131 0.0302
Schistosoma mansoni biogenic amine (5HT) receptor 0.0179 0.0937 0.101
Echinococcus granulosus chromobox protein 1 0.0071 0.0325 0.035
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.0166 0.0178
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0215 0.1192
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0018 0.0023 0.0066
Echinococcus granulosus sodium and chloride dependent glycine 0.0081 0.0385 0.0415
Echinococcus multilocularis expressed conserved protein 0.0202 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.0788 0.4395 0.4738
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.001 0.001
Loa Loa (eye worm) notch protein 0.0046 0.0184 0.0198
Schistosoma mansoni hypothetical protein 0.0043 0.0166 0.0178
Onchocerca volvulus 0.0031 0.01 0.0205
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0196 0.0212
Echinococcus multilocularis fmrfamide receptor 0.0043 0.0166 0.0166
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0196 0.0212
Loa Loa (eye worm) hypothetical protein 0.0788 0.4395 0.4738
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0165 0.2798
Schistosoma mansoni biogenic amine receptor 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0052 0.0218 0.0235
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0218 0.1206
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.0166 0.0178
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.0166 0.0166
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0033 0.043
Echinococcus granulosus hypothetical protein 0.0813 0.4537 0.4891
Loa Loa (eye worm) hypothetical protein 0.0788 0.4395 0.4738
Loa Loa (eye worm) Notch2 0.0046 0.0184 0.0198
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0018 0.0023 0.0076
Echinococcus granulosus Niemann Pick C1 protein 0.0216 0.1146 0.1236
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0081 0.0385 0.0415
Schistosoma mansoni hypothetical protein 0.0089 0.0429 0.0463
Brugia malayi Calcium binding EGF domain containing protein 0.0046 0.0184 0.0198
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0567 0.2808
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0219 0.1165 0.1256
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0081 0.0385 0.2177
Mycobacterium ulcerans hypothetical protein 0.0052 0.0218 0.1206
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0018 0.0023 0.0076
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Echinococcus multilocularis Niemann Pick C1 protein 0.0216 0.1146 0.1146
Echinococcus multilocularis protein dispatched 1 0.0106 0.0522 0.0522
Loa Loa (eye worm) blistered cuticle protein 3 0.0788 0.4395 0.4738
Echinococcus multilocularis serotonin receptor 0.0179 0.0937 0.0937
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0215 0.1192
Schistosoma mansoni hypothetical protein 0.0043 0.0166 0.0178
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0714 0.077
Schistosoma mansoni notch 0.0046 0.0184 0.0198
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0143 0.0332
Schistosoma mansoni chromobox protein 0.0071 0.0325 0.035
Schistosoma mansoni hypothetical protein 0.0046 0.0184 0.0198
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0081 0.0385 0.0415
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0106 0.0561
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.0166 0.0178
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0027 0.0075 0.0081
Schistosoma mansoni amine GPCR 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0166 0.0178
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.025 0.0269
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0024
Echinococcus granulosus neuropeptide receptor 0.0043 0.0166 0.0178
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0043 0.0166 0.0166
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0325 0.035
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.001 0.0001
Onchocerca volvulus 0.0081 0.0385 0.0856
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.0166 0.0178
Loa Loa (eye worm) hypothetical protein 0.0046 0.0184 0.0198
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.001 0.001
Onchocerca volvulus 0.0043 0.0166 0.0356

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.1886 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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