Detailed information for compound 1067417

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 335.295 | Formula: C15H18N3O4P
  • H donors: 3 H acceptors: 4 LogP: 1.15 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cn1c(nc2c1cccc2N)c1ccc(o1)P(=O)(O)O)C
  • InChi: 1S/C15H18N3O4P/c1-9(2)8-18-11-5-3-4-10(16)14(11)17-15(18)12-6-7-13(22-12)23(19,20)21/h3-7,9H,8,16H2,1-2H3,(H2,19,20,21)
  • InChiKey: GJBFVWNLEVOMBK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Fructose-1,6-bisphosphatase Starlite/ChEMBL References
Homo sapiens fructose-1,6-bisphosphatase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania infantum fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Toxoplasma gondii fructose-bisphospatase II Get druggable targets OG5_127400 All targets in OG5_127400
Schistosoma mansoni fructose-16-bisphosphatase-related Get druggable targets OG5_127400 All targets in OG5_127400
Echinococcus granulosus fructose 16 bisphosphatase 1 Get druggable targets OG5_127400 All targets in OG5_127400
Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania mexicana fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Loa Loa (eye worm) fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma congolense fructose-1,6-bisphosphate, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Schistosoma japonicum ko:K03841 fructose-1,6-bisphosphatase I, putative Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Candida albicans similar to S. cerevisiae FBP1 (YLR377C) Fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania donovani fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Neospora caninum Fructose-1 6-biphosphatase, related Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma brucei fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania braziliensis fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma brucei gambiense fructose-1,6-bisphosphate, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus CES-1 homolog Fructose-1,6-bisphosphatase   363 aa 319 aa 60.5 %
Toxoplasma gondii fructose-bisphospatase I fructose-1,6-bisphosphatase 1 338 aa 326 aa 31.0 %
Toxoplasma gondii fructose-bisphospatase I Fructose-1,6-bisphosphatase   363 aa 326 aa 31.3 %
Neospora caninum fructose-1,6-bisphosphatase, putative Fructose-1,6-bisphosphatase   363 aa 298 aa 32.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0068 0.0067
Brugia malayi neuropeptide F receptor 0.0033 0.0161 0.0383
Loa Loa (eye worm) hypothetical protein 0.0093 0.057 0.092
Brugia malayi hypothetical protein 0.0033 0.0161 0.0383
Onchocerca volvulus 0.0033 0.0161 0.0336
Echinococcus multilocularis geminin 0.0934 0.6305 0.6305
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Brugia malayi Dopamine receptor protein 1 0.0033 0.0161 0.0383
Onchocerca volvulus 0.0077 0.0458 0.0962
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Echinococcus granulosus 7TM GPCR rhodopsin 0.0033 0.0161 0.0159
Onchocerca volvulus 0.0018 0.0059 0.0122
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0005 0.0001
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0099 0.0433
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0005 0.0008
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0211 0.034
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0458 0.1097
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.009
Brugia malayi Bromodomain containing protein 0.001 0.0004 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0161 0.0252
Schistosoma mansoni smad1 5 8 and 0.0041 0.0211 0.0333
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0058 0.0056
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0098 0.0604 0.264
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Onchocerca volvulus 0.0024 0.0099 0.0206
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.0262 0.1719 0.2724
Onchocerca volvulus 0.0033 0.0161 0.0336
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.027 0.0646
Brugia malayi Bromodomain containing protein 0.001 0.0004 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0093 0.057 0.1367
Echinococcus multilocularis tar DNA binding protein 0.0322 0.2133 0.2131
Brugia malayi Cation transporter family protein 0.0018 0.0059 0.0139
Echinococcus granulosus g protein coupled receptor 0.0033 0.0161 0.0159
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1082 0.2275
Schistosoma mansoni Smad4 0.0041 0.0211 0.0333
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0077 0.0458 0.0738
Loa Loa (eye worm) hypothetical protein 0.0093 0.057 0.092
Toxoplasma gondii HEAT repeat-containing protein 0.0016 0.0045 0.0178
Trichomonas vaginalis esterase, putative 0.0077 0.0458 0.0957
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0003 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0322 0.2133 0.3381
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0458 0.1261
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0059 0.0058
Brugia malayi TspO/MBR family protein 0.0262 0.1719 0.4132
Brugia malayi MH1 domain containing protein 0.0022 0.0088 0.0207
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0378 0.2514 0.3985
Echinococcus multilocularis neuropeptide receptor A26 0.1475 1 1
Schistosoma mansoni coup transcription factor 0.0093 0.057 0.0901
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0099 0.015
Onchocerca volvulus 0.001 0.0004 0.0006
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0044 0.0234 0.0376
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.001 0.0005 0.0003
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0059 0.0058
Schistosoma mansoni calpain (C02 family) 0.0044 0.0232 0.0366
Brugia malayi sulfakinin receptor protein 0.0033 0.0161 0.0383
Brugia malayi calpain 5 0.0044 0.0232 0.0555
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0161 0.0252
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0063 0.0365 0.0873
Loa Loa (eye worm) hypothetical protein 0.0093 0.057 0.092
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.015 0.0357
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0458 0.0456
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.001 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.0376
Schistosoma mansoni calpain-7 (C02 family) 0.0047 0.0254 0.04
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.0376
Echinococcus granulosus lamin dm0 0.0032 0.015 0.0148
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0003 0.0045
Trypanosoma cruzi Bromodomain factor 1 0.001 0.0004 0.0007
Brugia malayi Nuclear hormone receptor E75 0.0044 0.0234 0.0559
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.0376
Trypanosoma cruzi ISWI complex protein 0.0017 0.0051 0.0193
Schistosoma mansoni amine GPCR 0.0033 0.0161 0.0252
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0033 0.0161 0.0159
Loa Loa (eye worm) CBP-B 0.001 0.0004 0.0004
Echinococcus multilocularis snurportin 1 0.0915 0.6177 0.6177
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0234 0.0369
Loa Loa (eye worm) hypothetical protein 0.0262 0.1719 0.2781
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Onchocerca volvulus 0.0033 0.0161 0.0336
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0147 0.0937 0.1483
Loa Loa (eye worm) hypothetical protein 0.0086 0.0519 0.0838
Echinococcus multilocularis FTZ F1 alpha 0.0093 0.057 0.0568
Brugia malayi MH2 domain containing protein 0.0041 0.0211 0.0505
Onchocerca volvulus 0.0147 0.094 0.198
Brugia malayi Importin beta-1 subunit 0.0086 0.0519 0.1245
Schistosoma mansoni tar DNA-binding protein 0.0322 0.2133 0.3381
Loa Loa (eye worm) calpain family protein 1 0.0103 0.0638 0.1031
Loa Loa (eye worm) hypothetical protein 0.0093 0.057 0.092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0161 0.0252
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0019 0.0062 0.947
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0154 0.0988 0.1564
Echinococcus multilocularis G-protein coupled receptor, putative 0.0033 0.0161 0.0159
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0232 0.0915
Plasmodium vivax bromodomain protein, putative 0.001 0.0004 0.0076
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Brugia malayi RNA binding protein 0.0322 0.2133 0.5128
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0416 0.2156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.1578 0.1576
Entamoeba histolytica protein kinase, putative 0.0044 0.0232 0.1016
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Toxoplasma gondii bromodomain-containing protein 0.001 0.0004 0.0017
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0068 0.1244
Loa Loa (eye worm) hypothetical protein 0.0147 0.0937 0.1514
Echinococcus multilocularis CREB binding protein 0.001 0.0004 0.0003
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0059 0.0058
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0059 0.0139
Loa Loa (eye worm) Smad1 0.0041 0.0211 0.034
Onchocerca volvulus 0.0044 0.0234 0.049
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Entamoeba histolytica bromodomain-containing protein 0.001 0.0004 0.0019
Mycobacterium ulcerans hypothetical protein 0.0077 0.0458 0.2408
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0024 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1082 0.2275
Onchocerca volvulus 0.0262 0.1719 0.3624
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0044 0.0234 0.0232
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0141 0.0893 0.3554
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0416 0.0657
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0093 0.057 0.0568
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0093 0.057 0.0568
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0089 0.0544 0.2164
Trypanosoma brucei C-8 sterol isomerase, putative 0.0177 0.114 0.4524
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0161 0.0159
Brugia malayi ecdysteroid receptor 0.0093 0.057 0.1367
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0099 0.0251
Plasmodium vivax transportin, putative 0.0016 0.0045 0.0776
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0234 0.0232
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0063 0.0365 0.0363
Leishmania major hypothetical protein, conserved 0.0016 0.0045 0.0161
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0033 0.0161 0.0383
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0065 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0093 0.057 0.1367
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.0011 0.0009
Echinococcus multilocularis orexin receptor type 2 0.0033 0.0161 0.0159
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0161 0.0252
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0093 0.057 0.0568
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0019 0.0062 1
Loa Loa (eye worm) DR-78 0.0044 0.0234 0.0376
Toxoplasma gondii bromodomain-containing protein 0.001 0.0004 0.0017
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0059 0.0094
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.001 0.0005 0.0005
Onchocerca volvulus 0.0077 0.0458 0.0962
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Echinococcus multilocularis smad 0.0041 0.0211 0.021
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.0376
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0099 0.0251
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0049 0.027 0.0426
Echinococcus granulosus smad 0.0041 0.0211 0.021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0093 0.057 0.0901
Echinococcus granulosus thyroid hormone receptor alpha 0.0044 0.0234 0.0232
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1144 0.2405
Brugia malayi photoreceptor-specific nuclear receptor 0.0093 0.057 0.1367
Brugia malayi hypothetical protein 0.0033 0.0161 0.0383
Loa Loa (eye worm) intermediate filament protein 0.0032 0.015 0.024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Plasmodium vivax hypothetical protein, conserved 0.001 0.0004 0.0076
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0232 0.0915
Loa Loa (eye worm) kap beta 3 protein 0.0016 0.0045 0.007
Leishmania major kinesin, putative 0.0044 0.0232 0.0909
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.1578 0.25
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.009
Toxoplasma gondii ABC1 family protein 0.0077 0.0458 0.182
Plasmodium vivax SET domain protein, putative 0.0089 0.0544 0.9418
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.0376
Mycobacterium tuberculosis Conserved protein 0.0077 0.0458 0.1261
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1683 0.3545
Loa Loa (eye worm) bromodomain containing protein 0.001 0.0004 0.0004
Onchocerca volvulus 0.0033 0.0161 0.0336
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0058 0.0091
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0044 0.0234 0.0232
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0378 0.2514 0.4068
Brugia malayi Bromodomain containing protein 0.001 0.0004 0.0007
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0154 0.0988 0.1564
Toxoplasma gondii hypothetical protein 0.001 0.0004 0.0017
Echinococcus multilocularis lamin 0.0032 0.015 0.0148
Schistosoma mansoni myosin xvIII 0.0033 0.0161 0.0252
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1082 0.2275
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.009
Echinococcus granulosus GPCR family 2 0.0164 0.1054 0.1053
Loa Loa (eye worm) hypothetical protein 0.0093 0.057 0.092
Echinococcus multilocularis polybromo 1 0.001 0.0004 0.0003
Echinococcus multilocularis importin subunit beta 1 0.0086 0.0519 0.0517
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Schistosoma mansoni nuclear receptor 0.0044 0.0234 0.0369
Onchocerca volvulus 0.0077 0.0458 0.0962
Schistosoma mansoni thyroid hormone receptor 0.0093 0.057 0.0901
Onchocerca volvulus Protein ultraspiracle homolog 0.0093 0.057 0.1199
Onchocerca volvulus 0.0033 0.0161 0.0336
Schistosoma mansoni amine GPCR 0.0033 0.0161 0.0252
Schistosoma mansoni nuclear receptor 0.0044 0.0234 0.0369
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0044 0.0234 0.0232
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0068 0.0067
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0099 0.0251
Brugia malayi hypothetical protein 0.0049 0.027 0.0646
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0059 0.0092
Schistosoma mansoni Smad4 0.0018 0.0058 0.009
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0068 0.0161
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0455 0.0453
Brugia malayi hypothetical protein 0.0044 0.0234 0.0559
Loa Loa (eye worm) beta-lactamase 0.0077 0.0458 0.0738
Schistosoma mansoni biogenic amine receptor 0.0033 0.0161 0.0252
Echinococcus granulosus hypothetical protein 0.0033 0.0161 0.0159
Brugia malayi polybromodomain protein 0.001 0.0004 0.0007
Brugia malayi hypothetical protein 0.0044 0.0234 0.0559
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0161 0.0258
Trypanosoma cruzi ISWI complex protein 0.0017 0.0051 0.0193
Giardia lamblia Histone acetyltransferase GCN5 0.0084 0.0507 0.2203
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0416 0.2156
Brugia malayi Bromodomain containing protein 0.0093 0.0571 0.1371
Schistosoma mansoni neuropeptide receptor 0.0033 0.0161 0.0252
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0177 0.114 0.2738
Schistosoma mansoni RAR-like nuclear receptor 0.0093 0.057 0.0901
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0099 0.0377
Brugia malayi ecdysone receptor 0.0044 0.0234 0.0559
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Schistosoma mansoni Mername-AA248 (C02 family) 0.0044 0.0232 0.0366
Onchocerca volvulus Putative nachr subunit 0.0018 0.0059 0.0122
Echinococcus multilocularis PH interacting protein 0.001 0.0004 0.0003
Brugia malayi Melatonin receptor type 1A 0.0033 0.0161 0.0383
Brugia malayi beta-lactamase family protein 0.0077 0.0458 0.1097
Schistosoma mansoni hypothetical protein 0.0033 0.0161 0.0252
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0094 0.0578 1
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0099 0.0234
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0378 0.2514 1
Echinococcus granulosus ATPase family AAA domain containing protein 2B 0.001 0.0004 0.0003
Echinococcus granulosus intermediate filament protein 0.0032 0.015 0.0148
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0158
Toxoplasma gondii bromodomain-containing protein 0.001 0.0004 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Mycobacterium ulcerans beta-lactamase 0.0077 0.0458 0.2408
Echinococcus granulosus neuropeptide FF receptor 2 0.0033 0.0161 0.0159
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0064 0.01
Entamoeba histolytica bromodomain-containing protein 0.001 0.0004 0.0019
Plasmodium vivax calpain, putative 0.0044 0.0232 0.4024
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0161 0.0159
Brugia malayi Bromodomain containing protein 0.001 0.0004 0.0007
Schistosoma mansoni growth hormone secretagogue receptor 0.0033 0.0161 0.0252
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0059 0.0058
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0005 0.0005
Brugia malayi ATPase, AAA family protein 0.001 0.0004 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0108 0.0674 0.1067
Echinococcus granulosus neuropeptide receptor 0.0033 0.0161 0.0159
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0065 0.0044
Brugia malayi larval opioid receptor 0.0033 0.0161 0.0383
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0158
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0161 0.0252
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0915 0.6177 1
Leishmania major GTP-binding protein, putative 0.0063 0.0365 0.1436
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0161 0.0252
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0063 0.0365 0.1442
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0093 0.057 0.092
Loa Loa (eye worm) hypothetical protein 0.0049 0.027 0.0435
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0005 0.0003
Echinococcus granulosus nAChR subunit 0.0018 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0108 0.0674 0.1089
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0033 0.0161 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0093 0.057 0.1367
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0033 0.0161 0.0159
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.001 0.0005 0.0005
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0044 0.0232 0.0909
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0069 0.0408 0.0853
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.001 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Entamoeba histolytica G protein alpha subunit, putative 0.001 0.0005 0.0021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Brugia malayi G-protein coupled receptor 0.0033 0.0161 0.0383
Schistosoma mansoni alpha-1 adrenergic receptor 0.0033 0.0161 0.0252
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.0376
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0141 0.0893 0.3543
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0068 0.0255
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.001 0.0005 0.0008
Brugia malayi Pre-SET motif family protein 0.0089 0.0544 0.1305
Loa Loa (eye worm) hypothetical protein 0.0022 0.0088 0.0139
Echinococcus multilocularis dnaJ subfamily B 0.0458 0.3057 0.3055
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0033 0.0161 0.0336
Loa Loa (eye worm) calpain 0.0044 0.0232 0.0374
Loa Loa (eye worm) hypothetical protein 0.0262 0.1719 0.2781
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0058 0.0136
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0141 0.0893 0.3548
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0009 0.0008
Echinococcus granulosus Nuclear hormone receptor HR96 0.0044 0.0234 0.0232
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0033 0.0161 0.0252
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Echinococcus granulosus translational activator gcn1 0.0016 0.0045 0.0043
Onchocerca volvulus 0.0089 0.0544 0.1145
Onchocerca volvulus 0.0033 0.0161 0.0336
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0108 0.0674 0.0673
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0211 0.021
Trichomonas vaginalis ran, putative 0.0063 0.0365 0.0761
Echinococcus multilocularis translocator protein 0.0262 0.1719 0.1717
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0059 0.0139
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0161 0.0159
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0059 0.0139
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0059 0.0094
Entamoeba histolytica hypothetical protein 0.0113 0.0707 0.3091
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0099 0.0251
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0234 0.0232
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0458 0.2408
Brugia malayi G protein-coupled receptor F59B2.13 0.0033 0.0161 0.0383
Schistosoma mansoni nAChR subunit 0.0018 0.0059 0.0092
Brugia malayi hypothetical protein 0.0113 0.0707 0.1698
Trypanosoma brucei PAB1-binding protein , putative 0.0082 0.0493 0.1947
Echinococcus granulosus lamin 0.0032 0.015 0.0148
Brugia malayi acetyltransferase, GNAT family protein 0.0314 0.2079 0.4998
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.0376
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0232 0.0915
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0059 0.0094
Brugia malayi nuclear hormone receptor family member nhr-6 0.0044 0.0234 0.0559
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0059 0.0094
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0024 0.0037
Onchocerca volvulus 0.0018 0.0059 0.0122
Brugia malayi CXXC zinc finger family protein 0.0032 0.0153 0.0365
Brugia malayi Pre-SET motif family protein 0.0619 0.4157 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.057 0.092
Brugia malayi neuropeptide F receptor 0.0033 0.0161 0.0383
Toxoplasma gondii histone acetyltransferase TAF1/250 0.001 0.0004 0.0017
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0059 0.0139
Toxoplasma gondii HEAT repeat-containing protein 0.0086 0.0519 0.2065
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0033 0.0161 0.0159
Echinococcus multilocularis expressed protein 0.001 0.0005 0.0003
Echinococcus multilocularis neuropeptide s receptor 0.1475 1 1
Echinococcus granulosus fmrfamide receptor 0.0033 0.0161 0.0159
Onchocerca volvulus 0.0044 0.0234 0.049
Brugia malayi G-protein alpha subunit 0.001 0.0005 0.0008
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0004
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0068 0.0255
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0059 0.0094
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0058 0.0091
Loa Loa (eye worm) hypothetical protein 0.0018 0.0057 0.009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0164 0.1054 0.1053
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0059 0.0139
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0458 0.1261
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0161 0.0159
Echinococcus multilocularis dro:myosuppressin receptor 0.0033 0.0161 0.0159
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0044 0.0234 0.049
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0099 0.015
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0059 0.0092
Plasmodium vivax importin-beta 2, putative 0.0086 0.0519 0.8985
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.0376
Echinococcus granulosus cpg binding protein 0.0036 0.0181 0.0179
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0161 0.0159
Trypanosoma brucei kinesin, putative 0.0044 0.0232 0.0909
Loa Loa (eye worm) hypothetical protein 0.0082 0.0493 0.0796
Trypanosoma cruzi Bromodomain, putative 0.001 0.0004 0.0007
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0049 0.027 0.0268
Onchocerca volvulus 0.0033 0.0161 0.0336
Loa Loa (eye worm) melatonin receptor type 1A 0.0033 0.0161 0.0258
Brugia malayi RE15519p 0.0033 0.0161 0.0383
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0057 0.0993
Brugia malayi G protein-coupled receptor 0.0033 0.0161 0.0383
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0161 0.0159
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Schistosoma mansoni amine GPCR 0.0033 0.0161 0.0252
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0016 0.0045 0.0161
Brugia malayi hypothetical protein 0.0033 0.0161 0.0383
Brugia malayi G-protein coupled receptor 0.0033 0.0161 0.0383
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0458 0.1812
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0059 0.0058
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0068 0.0135
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0068 0.0067
Trichomonas vaginalis lymphoid specific helicase, putative 0.001 0.0004 0.00000000011686
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0065 0.0128
Echinococcus granulosus peptide allatostatin:somatostatin 0.0033 0.0161 0.0159
Entamoeba histolytica hypothetical protein 0.001 0.0004 0.0019
Brugia malayi TAZ zinc finger family protein 0.001 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0262 0.1719 0.2781
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0232 0.0909
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0005 0.0005
Schistosoma mansoni amine GPCR 0.0033 0.0161 0.0252
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0161 0.0252
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0059 0.0092
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0005 0.0003
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0062 0.0026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.1578 0.1576
Brugia malayi N-terminal motif family protein 0.0184 0.1189 0.2858
Brugia malayi orphan nuclear receptor NR2E1 0.0044 0.0234 0.0559
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0161 0.0252
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0059 0.0139
Echinococcus granulosus tachykinin peptides receptor 99D 0.0033 0.0161 0.0159
Schistosoma mansoni hypothetical protein 0.0164 0.1054 0.167
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0033 0.0161 0.0252
Entamoeba histolytica HEAT repeat domain containing protein 0.0016 0.0045 0.0196
Loa Loa (eye worm) hypothetical protein 0.0043 0.0227 0.0365
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0059 0.0058
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0038 0.0087
Echinococcus granulosus peregrin 0.001 0.0004 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0093 0.057 0.092
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0059 0.0092
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0458 0.0738
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0033 0.0161 0.0159
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0232 0.0915
Echinococcus granulosus importin 5 0.0016 0.0045 0.0043
Echinococcus granulosus neuropeptide receptor A26 0.1475 1 1
Schistosoma mansoni lamin 0.0032 0.015 0.0235
Schistosoma mansoni bromodomain containing protein 0.001 0.0004 0.0004
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0232 0.0909
Brugia malayi nuclear receptor NHR-67 0.0044 0.0234 0.0559
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0063 0.0365 0.0588
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Onchocerca volvulus 0.0033 0.0161 0.0336
Plasmodium falciparum ataxin-2 like protein, putative 0.0082 0.0493 0.9495
Brugia malayi Dopamine receptor 0.0033 0.0161 0.0383
Leishmania major 0.0378 0.2514 1
Echinococcus granulosus allatostatin A receptor 0.0033 0.0161 0.0159
Onchocerca volvulus 0.0032 0.0153 0.032
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Echinococcus multilocularis glutamate receptor 2 0.0011 0.0009 0.0008
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0005 0.0005
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0208 0.0207
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.0376
Onchocerca volvulus 0.0018 0.0059 0.0122
Brugia malayi calpain family protein 1 0.0147 0.0937 0.225
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0161 0.0252
Plasmodium vivax bromodomain protein, putative 0.001 0.0004 0.0076
Plasmodium falciparum ataxin-2 like protein, putative 0.0082 0.0493 0.9495
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0093 0.057 0.0568
Schistosoma mansoni helicase 0.001 0.0004 0.0004
Schistosoma mansoni smad1 5 8 and 0.0041 0.0211 0.0333
Schistosoma mansoni steroid hormone receptor ad4bp 0.0093 0.057 0.0901
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0005 0.0005
Giardia lamblia DNA repair protein RAD52 0.0345 0.2288 1
Schistosoma mansoni CREB-binding protein 2 0.001 0.0004 0.0004
Onchocerca volvulus 0.0262 0.1719 0.3624
Loa Loa (eye worm) hypothetical protein 0.0262 0.1719 0.2781
Onchocerca volvulus 0.0033 0.0161 0.0336
Schistosoma mansoni lamin 0.0032 0.015 0.0235
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0544 0.086
Echinococcus granulosus ecdysone induced protein 78C 0.0093 0.057 0.0568
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0065 0.0241
Onchocerca volvulus 0.0093 0.057 0.1199
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0059 0.0139
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0063 0.0365 0.1577
Schistosoma mansoni hypothetical protein 0.0164 0.1054 0.167
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0059 0.0139
Onchocerca volvulus 0.0018 0.0059 0.0122
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0093 0.057 0.0568
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0345 0.2288 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0093 0.057 0.1367
Schistosoma mansoni smad 0.0041 0.0211 0.0333
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.001 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0147 0.0937 0.1514
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0059 0.0058
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0416 0.0657
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0065 0.1125
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Loa Loa (eye worm) MH2 domain-containing protein 0.0596 0.4003 0.6479
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1683 0.3545
Trichomonas vaginalis bromodomain-containing protein, putative 0.0094 0.0578 0.1211
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0164 0.1054 0.1053
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0458 0.1261
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0161 0.0159
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.001 0.0005 0.0008
Brugia malayi RNA recognition motif domain containing protein 0.0322 0.2133 0.5128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.1578 0.25
Entamoeba histolytica hypothetical protein 0.0113 0.0707 0.3091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.1578 0.25
Plasmodium vivax conserved Plasmodium protein, unknown function 0.001 0.0004 0.0076
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0093 0.057 0.1367
Entamoeba histolytica bromodomain-containing protein 0.001 0.0004 0.0019
Brugia malayi intermediate filament protein 0.0032 0.015 0.0357
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0068 0.0161
Trichomonas vaginalis set domain proteins, putative 0.0704 0.474 1
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.001 0.0005 0.0001
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0005 0.0003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0241 0.1578 0.3792
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0458 0.0957
Schistosoma mansoni hypothetical protein 0.0164 0.1054 0.167
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0458 0.1261
Onchocerca volvulus 0.0032 0.015 0.0313
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0161 0.0159
Schistosoma mansoni bromodomain containing 0.001 0.0004 0.0004
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0161 0.0252
Echinococcus multilocularis sex peptide receptor 0.0033 0.0161 0.0159
Schistosoma mansoni nAChR subunit 0.0018 0.0059 0.0092
Brugia malayi Serotonin receptor 0.0033 0.0161 0.0383
Loa Loa (eye worm) hypothetical protein 0.0103 0.0638 0.1031
Loa Loa (eye worm) importin-beta domain-containing protein 0.0016 0.0045 0.007
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0458 0.0957
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0093 0.057 0.1367
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0011 0.0009 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0093 0.057 0.0568
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Schistosoma mansoni nAChR subunit 0.0018 0.0059 0.0092
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0059 0.0058
Brugia malayi GnHR receptor homolog 0.0033 0.0161 0.0383
Echinococcus multilocularis 0.001 0.0004 0.0003
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0059 0.0058
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0005 0.0005
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0065 0.0063
Brugia malayi Bromodomain containing protein 0.001 0.0004 0.0007
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0161 0.0159
Onchocerca volvulus 0.0704 0.474 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0018 0.0058 0.0119
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0119 0.0186
Echinococcus granulosus CREB binding protein 0.001 0.0004 0.0003
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0033 0.0161 0.0252
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0232 0.0915
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0093 0.057 0.0568
Echinococcus multilocularis serotonin receptor 0.0033 0.0161 0.0159
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0033 0.0161 0.0258
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0068 0.0161
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Loa Loa (eye worm) TYRA-2 protein 0.0033 0.0161 0.0258
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.1683 0.2723
Echinococcus granulosus calpain A 0.0044 0.0232 0.0231
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0458 0.2408
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0068 0.1244
Schistosoma mansoni smad 0.0018 0.0058 0.009
Schistosoma mansoni calpain-7 (C02 family) 0.0047 0.0254 0.04
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0099 0.0251
Brugia malayi nuclear receptor NHR-88 0.0044 0.0234 0.0559
Brugia malayi follicle stimulating hormone receptor 0.0033 0.0161 0.0383
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0094 0.0578 0.2298
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0005 0.0003
Plasmodium vivax SET domain containing protein 0.0014 0.0031 0.0544
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0057 0.103
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0068 0.0272
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0314 0.2079 0.3295
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.0707 0.1119
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.001 0.0005 0.0008
Echinococcus granulosus translocator protein 0.0262 0.1719 0.1717
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0378 0.2514 0.2512
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0161 0.0159
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0211 0.0333
Entamoeba histolytica recQ family helicase, putative 0.002 0.0068 0.0299
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Brugia malayi Nuclear hormone receptor E75 0.0044 0.0234 0.0559
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0314 0.2079 0.2078
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0164 0.1054 0.1053
Entamoeba histolytica Ran family GTPase 0.0063 0.0365 0.1593
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0161 0.0159
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.001 0.0004 0.0004
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0161 0.0159
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0048
Schistosoma mansoni hypothetical protein 0.0033 0.0161 0.0252
Echinococcus granulosus geminin 0.0934 0.6305 0.6305
Schistosoma mansoni phd finger protein 0.001 0.0004 0.0004
Mycobacterium ulcerans hypothetical protein 0.0024 0.0099 0.0251
Schistosoma mansoni hypothetical protein 0.0934 0.6305 1
Entamoeba histolytica calpain large subunit domain III containing protein 0.0044 0.0232 0.1016
Schistosoma mansoni ran 0.0063 0.0365 0.0576
Trichomonas vaginalis importin beta-1, putative 0.0069 0.0408 0.0853
Brugia malayi hypothetical protein 0.0033 0.0161 0.0383
Echinococcus granulosus calpain 0.0044 0.0232 0.0231
Schistosoma mansoni nAChR subunit 0.0018 0.0059 0.0092
Echinococcus granulosus histone acetyltransferase KAT2B 0.0303 0.2001 0.2
Loa Loa (eye worm) hypothetical protein 0.0177 0.114 0.1843
Mycobacterium ulcerans tryptophan-rich sensory protein 0.0262 0.1719 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0519 0.3475 0.5624
Mycobacterium tuberculosis Conserved protein 0.0077 0.0458 0.1261
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0033 0.0161 0.0252
Onchocerca volvulus 0.0262 0.1719 0.3624
Brugia malayi MH1 domain containing protein 0.0022 0.0088 0.0207
Toxoplasma gondii bromodomain-containing protein 0.001 0.0004 0.0017
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0161 0.0159
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0378 0.2514 1
Toxoplasma gondii bromodomain-containing protein 0.001 0.0004 0.0017
Loa Loa (eye worm) RecQ helicase 0.002 0.0068 0.0108
Schistosoma mansoni DNA helicase recq5 0.002 0.0068 0.0106
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0232 0.0915
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Onchocerca volvulus 0.0033 0.0161 0.0336
Echinococcus granulosus FTZ F1 alpha 0.0093 0.057 0.0568
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0059 0.0139
Brugia malayi MH2 domain containing protein 0.0596 0.4003 0.9628
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0093 0.057 0.0901
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0113 0.0707 0.1119
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0033 0.0161 0.0159
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.001 0.0005 0.0005
Brugia malayi nuclear hormone receptor 0.0044 0.0234 0.0559
Brugia malayi BRM protein 0.001 0.0004 0.0007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0241 0.1578 0.2552
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0016 0.0045 0.0161
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0059 0.0094
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0059 0.0058
Schistosoma mansoni neuropeptide f receptor 76f 0.0033 0.0161 0.0252
Loa Loa (eye worm) TAR-binding protein 0.0322 0.2133 0.3451
Onchocerca volvulus 0.0033 0.0161 0.0336
Echinococcus granulosus dro:myosuppressin receptor 0.0033 0.0161 0.0159
Echinococcus granulosus transcription initiation factor TFIID subunit 1 0.001 0.0004 0.0003
Echinococcus multilocularis calpain 5 0.0044 0.0232 0.0231
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0033 0.0161 0.0252
Onchocerca volvulus 0.001 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0184 0.1189 0.1923
Brugia malayi nuclear receptor RXR 0.0044 0.0234 0.0559
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0063 0.0365 0.1436
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0458 0.1812
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0093 0.057 0.1367
Echinococcus granulosus 7tm_1 domain containing protein 0.0033 0.0161 0.0159
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0033 0.0161 0.0383
Onchocerca volvulus 0.0262 0.1719 0.3624
Echinococcus multilocularis transportin 1 0.0016 0.0045 0.0043
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0065 0.0241
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.005 0.0078
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Schistosoma mansoni retinoic acid receptor RXR 0.0093 0.057 0.0901
Echinococcus multilocularis bromodomain containing protein 8 0.001 0.0004 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0093 0.057 0.1367
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0044 0.0234 0.0369
Onchocerca volvulus 0.001 0.0004 0.0006
Brugia malayi hypothetical protein 0.0033 0.0161 0.0383
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Loa Loa (eye worm) hypothetical protein 0.0147 0.094 0.1519
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0033 0.0161 0.0258
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0161 0.0258
Trypanosoma cruzi Bromodomain, putative 0.001 0.0004 0.0007
Loa Loa (eye worm) acetyltransferase 0.0314 0.2079 0.3364
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0164 0.1054 0.1053
Schistosoma mansoni hypothetical protein 0.0017 0.0051 0.0078
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0161 0.0159
Schistosoma mansoni ap endonuclease 0.0019 0.0065 0.01
Echinococcus multilocularis bromodomain containing 2 0.001 0.0004 0.0003
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0141 0.0893 0.3548
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0033 0.0161 0.0159
Onchocerca volvulus Brd8 homolog 0.001 0.0004 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0004 0.0007
Trypanosoma cruzi PAB1-binding protein , putative 0.0082 0.0493 0.1953
Loa Loa (eye worm) hypothetical protein 0.0018 0.0058 0.0091
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0378 0.2514 0.2512
Loa Loa (eye worm) hypothetical protein 0.0079 0.0474 0.0765
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Echinococcus granulosus g protein coupled receptor 0.0033 0.0161 0.0159
Brugia malayi hypothetical protein 0.0033 0.0161 0.0383
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0211 0.034
Echinococcus multilocularis calpain 0.0044 0.0232 0.0231
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0059 0.0058
Schistosoma mansoni opsin-like receptor 0.0033 0.0161 0.0252
Leishmania major C-8 sterol isomerase-like protein 0.0177 0.114 0.4524
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0065 0.0248
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.1578 0.1576
Echinococcus granulosus bromodomain containing 2 0.001 0.0004 0.0003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0093 0.057 0.0901
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0177 0.114 0.4528
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Chlamydia trachomatis glutamine binding protein 0.0019 0.0062 1
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0416 0.1653
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor 0.0044 0.0234 0.0376
Echinococcus granulosus PH interacting protein 0.001 0.0004 0.0003
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0208 0.0207
Plasmodium falciparum bromodomain protein 1 0.001 0.0004 0.00000049247
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0161 0.0159
Schistosoma mansoni smad1 5 8 and 0.0041 0.0211 0.0333
Entamoeba histolytica hypothetical protein 0.0113 0.0707 0.3091
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0119 0.0117
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0416 0.1131
Echinococcus granulosus Bromodomain containing protein 0.001 0.0004 0.0003
Schistosoma mansoni importin-beta 2 0.0016 0.0045 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1082 0.2275
Brugia malayi PHD-finger family protein 0.0037 0.0189 0.0451
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0161 0.0159
Echinococcus granulosus G protein coupled receptor 139 0.0033 0.0161 0.0159
Schistosoma mansoni adenoreceptor 0.0033 0.0161 0.0252
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0093 0.057 0.0901
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.001 0.0004 0.0017
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0059 0.0139
Onchocerca volvulus 0.001 0.0004 0.0006
Schistosoma mansoni Smad4 0.0018 0.0058 0.009
Brugia malayi Steroid receptor seven-up type 2 0.0093 0.057 0.1367
Trypanosoma cruzi kinesin, putative 0.0044 0.0232 0.0915
Brugia malayi hypothetical protein 0.0147 0.094 0.2258
Brugia malayi hypothetical protein 0.0033 0.0161 0.0383
Echinococcus granulosus serotonin receptor 0.0033 0.0161 0.0159
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0019 0.0062 0.947
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0093 0.057 0.0568
Schistosoma mansoni neuropeptide receptor 0.0033 0.0161 0.0252
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0161 0.0252
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0099 0.0251
Brugia malayi Dopamine receptor protein 2 0.0033 0.0161 0.0383
Echinococcus granulosus alpha 1A adrenergic receptor 0.0033 0.0161 0.0159
Leishmania major hypothetical protein, conserved 0.0082 0.0493 0.1947
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0458 0.0456
Brugia malayi bromodomain containing protein 0.001 0.0004 0.0007
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0059 0.0058
Plasmodium falciparum transportin 0.0016 0.0045 0.0786
Echinococcus granulosus polybromo 1 0.001 0.0004 0.0003
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0033 0.0161 0.0252
Schistosoma mansoni hypothetical protein 0.0037 0.0185 0.0291
Echinococcus granulosus transportin 1 0.0016 0.0045 0.0043
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0063 0.0365 0.7
Entamoeba histolytica bromodomain-containing protein 0.001 0.0004 0.0019
Echinococcus granulosus somatostatin receptor 0.0033 0.0161 0.0159
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0093 0.057 0.0901
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0068 0.0262
Echinococcus multilocularis lamin dm0 0.0032 0.015 0.0148
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0009 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0458 0.1806
Schistosoma mansoni ap endonuclease 0.0019 0.0065 0.01
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0064 0.0063
Brugia malayi Bromodomain containing protein 0.001 0.0004 0.0007
Onchocerca volvulus Bile acid receptor homolog 0.0093 0.057 0.1199
Echinococcus granulosus g-protein coupled receptor 0.0033 0.0161 0.0159
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0005 0.0008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0519 0.3475 0.5624
Echinococcus granulosus calpain 7 C02 family 0.0044 0.0232 0.0231
Brugia malayi Nuclear hormone receptor-like 1 0.0093 0.057 0.1367
Brugia malayi Tachykinin-like peptides receptor 99D 0.0033 0.0161 0.0383
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0099 0.0234
Schistosoma mansoni nAChR subunit 0.0018 0.0059 0.0092
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0033 0.0161 0.0159
Schistosoma mansoni glutamate receptor NMDA 0.0011 0.0009 0.0012
Onchocerca volvulus 0.0033 0.0161 0.0336
Brugia malayi nuclear hormone receptor family member odr-7 0.0044 0.0234 0.0559
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0011 0.0009
Brugia malayi Smad1 0.0041 0.0211 0.0505
Echinococcus multilocularis calpain 7 (C02 family) 0.0044 0.0232 0.0231
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0059 0.0139
Toxoplasma gondii exonuclease III APE 0.0019 0.0065 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0093 0.057 0.1367
Brugia malayi steroid hormone receptor 0.0093 0.057 0.1367
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0161 0.0252
Echinococcus multilocularis bloom syndrome protein 0.002 0.0068 0.0067
Brugia malayi Calcitonin receptor-like protein seb-1 0.0519 0.3475 0.8357
Brugia malayi nuclear receptor RXR 0.0049 0.027 0.0646
Brugia malayi conserved hypotetical protein 0.0044 0.0234 0.0559
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0011 0.0015
Onchocerca volvulus Neuropeptide F receptor homolog 0.0033 0.0161 0.0336
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0161 0.0258
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0232 0.0909
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0009 0.0008
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0161 0.0258
Trypanosoma cruzi bromodomain-containing protein 3 0.001 0.0004 0.0007
Trypanosoma cruzi kinesin, putative 0.0044 0.0232 0.0915
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0044 0.0234 0.0232
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0458 0.0957
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0458 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0093 0.057 0.0568
Schistosoma mansoni hypothetical protein 0.0023 0.0092 0.0143
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0065 0.5
Schistosoma mansoni bromodomain containing protein 0.0014 0.0031 0.0047
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0161 0.0252
Onchocerca volvulus Bromodomain adjacent to zinc finger domain protein 1A homolog 0.001 0.0004 0.0006
Trypanosoma cruzi Bromodomain, putative 0.001 0.0004 0.0007
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0322 0.2133 0.3451
Entamoeba histolytica bromodomain-containing protein 0.001 0.0004 0.0019
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Echinococcus granulosus g protein coupled receptor 0.0033 0.0161 0.0159
Plasmodium vivax ataxin-2 like protein, putative 0.0082 0.0493 0.8535
Loa Loa (eye worm) RNA binding protein 0.0322 0.2133 0.3451
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0232 0.0915
Echinococcus multilocularis calpain A 0.0154 0.0988 0.0986
Brugia malayi latrophilin 2 splice variant baaae 0.0355 0.2355 0.5662
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0044 0.0234 0.0559
Echinococcus multilocularis calpain family protein 1, d 0.0103 0.0638 0.0637
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0059 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0093 0.057 0.1367
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.0376
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0089 0.0544 0.086
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0044 0.0234 0.0232
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0069 0.0408 0.0853
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0232 0.0915
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0211 0.021
Schistosoma mansoni biogenic amine receptor 0.0033 0.0161 0.0252
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0009 0.0008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0458 0.0723
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.001 0.0005 0.0008
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0059 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0093 0.057 0.0568
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0059 0.0058
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0093 0.057 0.1199
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0059 0.0058
Brugia malayi hypothetical protein 0.001 0.0005 0.0008
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0059 0.0139
Brugia malayi fructose-1,6-bisphosphatase 0.0378 0.2514 0.6044
Echinococcus multilocularis hypothetical protein 0.0044 0.0232 0.0231
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0161 0.0159
Entamoeba histolytica hypothetical protein 0.0098 0.0604 0.264
Onchocerca volvulus 0.0103 0.0638 0.1344
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Schistosoma mansoni nuclear hormone receptor 0.0093 0.057 0.0901
Trypanosoma cruzi bromodomain factor 2 protein 0.001 0.0004 0.0007
Echinococcus granulosus protein kinase C binding protein 1 0.001 0.0004 0.0003
Schistosoma mansoni neuropeptide receptor 0.0033 0.0161 0.0252
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0416 0.0414
Schistosoma mansoni biogenic amine receptor 0.0033 0.0161 0.0252
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0044 0.0232 0.0915
Loa Loa (eye worm) latrophilin receptor protein 2 0.0164 0.1054 0.1705
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0064 0.0063
Schistosoma mansoni DNA helicase recq1 0.002 0.0068 0.0106
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0011 0.0009 0.0008
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0154 0.0988 0.0986
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0161 0.0159
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0421 0.0666
Echinococcus granulosus neuropeptide receptor 0.0033 0.0161 0.0159
Echinococcus granulosus nuclear receptor nhr 48 0.0044 0.0234 0.0232
Echinococcus granulosus histone lysine methyltransferase setb 0.0108 0.0674 0.0673
Entamoeba histolytica ankyrin repeat protein, putative 0.001 0.0004 0.0019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0146 0.0234
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Schistosoma mansoni nAChR subunit 0.0018 0.0059 0.0092
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0232 0.0909
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0161 0.0159
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0232 0.0909
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0044 0.0232 0.0909
Giardia lamblia Transcription regulatory protein SNF2 0.001 0.0004 0.00000000024229
Echinococcus granulosus GTP binding nuclear protein Ran 0.0063 0.0365 0.0363
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Brugia malayi MH2 domain containing protein 0.0018 0.0058 0.0136
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0005 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1144 0.2405
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.001 0.0005 0.0001
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0064 0.01
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.0376
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0458 0.1261
Echinococcus multilocularis musashi 0.0032 0.015 0.0148
Schistosoma mansoni nAChR subunit 0.0018 0.0059 0.0092
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0161 0.0159
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0044 0.0232 0.0915
Echinococcus granulosus Nuclear hormone receptor HR96 0.0044 0.0234 0.0232
Brugia malayi kap beta 3 protein 0.0016 0.0045 0.0104
Echinococcus multilocularis allatostatin A receptor 0.0033 0.0161 0.0159
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0416 0.2156
Loa Loa (eye worm) calpain family protein 1 0.0147 0.0937 0.1514
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.015 0.024
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0011 0.0009 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0458 0.0957
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0005 0.0001
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0037 0.0185 0.0183
Schistosoma mansoni calpain C (C02 family) 0.0044 0.0232 0.0366
Schistosoma mansoni importin beta-1 0.0086 0.0519 0.0821
Entamoeba histolytica hypothetical protein 0.0069 0.0408 0.1785
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0011 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0077 0.0458 0.0738
Loa Loa (eye worm) bromodomain containing protein 0.0027 0.0121 0.0194
Loa Loa (eye worm) hypothetical protein 0.0355 0.2355 0.381
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0059 0.0058
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0119 0.0117
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0033 0.0161 0.0258
Schistosoma mansoni hypothetical protein 0.0033 0.0161 0.0252
Brugia malayi AKH receptor 0.0033 0.0161 0.0383
Loa Loa (eye worm) hypothetical protein 0.0077 0.0458 0.0738
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0089 0.0544 0.0542
Brugia malayi Cation transporter family protein 0.0018 0.0059 0.0139
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0005 0.0005
Schistosoma mansoni zinc finger protein 0.0017 0.0051 0.0078
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.001 0.0004 0.0004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0519 0.3475 0.8357
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0161 0.0252
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0068 0.0067
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.1082 0.2279
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0059 0.0058
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0093 0.057 0.0568
Echinococcus granulosus sex peptide receptor 0.0033 0.0161 0.0159
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0093 0.057 0.0568
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0005 0.0003
Schistosoma mansoni opsin-like receptor 0.0033 0.0161 0.0252
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0068 0.0272
Toxoplasma gondii LsmAD domain-containing protein 0.0082 0.0493 0.1961
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Onchocerca volvulus 0.0033 0.0161 0.0336
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0108
Leishmania major hypothetical protein, conserved 0.0017 0.0051 0.0186
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0005 0.0005
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0161 0.0159
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0068 0.028
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1683 0.3545
Toxoplasma gondii HEAT repeat-containing protein 0.0016 0.0045 0.0178
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0093 0.057 0.092
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Trypanosoma cruzi PAB1-binding protein , putative 0.0082 0.0493 0.1953
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0085 0.0517 0.0515
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0059 0.0058
Schistosoma mansoni transcription initiation factor tfiid 0.001 0.0004 0.0004
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0033 0.0161 0.0258
Schistosoma mansoni opsin-like receptor 0.0033 0.0161 0.0252
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0099 0.0234
Schistosoma mansoni tar DNA-binding protein 0.0322 0.2133 0.3381
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.0376
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.0707 0.0706
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0059 0.0058
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0059 0.0094
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0062 0.0034
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0033 0.0161 0.0258
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0099 0.0433
Brugia malayi nuclear receptor NHR-88 0.0093 0.057 0.1367
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0063 0.0365 0.145
Loa Loa (eye worm) steroid hormone receptor 0.0093 0.057 0.092
Brugia malayi calpain 7 0.0044 0.0232 0.0555
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0458 0.0723
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Schistosoma mansoni bromodomain containing protein 0.008 0.0482 0.0762
Echinococcus multilocularis Bromodomain containing protein 0.001 0.0004 0.0003
Echinococcus multilocularis peregrin 0.001 0.0004 0.0003
Brugia malayi Bromodomain containing protein 0.005 0.0279 0.0667
Echinococcus granulosus tar DNA binding protein 0.0322 0.2133 0.2131
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.1683 0.4046
Brugia malayi tailless protein 0.0044 0.0234 0.0559
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0161 0.0252
Brugia malayi Bromodomain containing protein 0.001 0.0004 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1082 0.2275
Leishmania major importin beta-1 subunit, putative 0.0069 0.0408 0.161
Loa Loa (eye worm) hypothetical protein 0.0053 0.0297 0.0479
Brugia malayi beta-lactamase family protein 0.0077 0.0458 0.1097
Brugia malayi Bromodomain containing protein 0.001 0.0004 0.0007
Entamoeba histolytica acetyltransferase, GNAT family 0.0084 0.0507 0.2218
Schistosoma mansoni trimeric G-protein alpha o subunit 0.001 0.0005 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0164 0.1054 0.2533
Loa Loa (eye worm) transcription factor SMAD2 0.0596 0.4003 0.6479
Schistosoma mansoni tar DNA-binding protein 0.0322 0.2133 0.3381
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0619 0.4157 0.6729
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0033 0.0161 0.0159
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0065 0.0046
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0161 0.0252
Trypanosoma cruzi Bromodomain, putative 0.001 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0099 0.0158
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0057 0.0021
Loa Loa (eye worm) hypothetical protein 0.0049 0.027 0.0435
Mycobacterium tuberculosis Conserved protein 0.0077 0.0458 0.1261
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.001 0.0005 0.0005
Echinococcus multilocularis serotonin receptor 0.0033 0.0161 0.0159
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0063 0.0365 0.6312
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0416 0.0414
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Brugia malayi putative neuropeptide receptor NPR1 0.0033 0.0161 0.0383
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0065 1
Echinococcus multilocularis cpg binding protein 0.0036 0.0181 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0093 0.057 0.092
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0099 0.0433
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0058 0.0056
Schistosoma mansoni thyroid hormone receptor 0.0093 0.057 0.0901
Schistosoma mansoni neuropeptide receptor 0.0033 0.0161 0.0252
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.001 0.0005 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.027 0.0646
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0232 0.0909
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0059 0.0094
Schistosoma mansoni zinc finger protein 0.0031 0.0148 0.0233
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0005 0.0003
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0059 0.0139
Brugia malayi ORL1-like opioid receptor 0.0033 0.0161 0.0383
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0099 0.0377
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0053
Echinococcus granulosus calpain A 0.0154 0.0988 0.0986
Schistosoma mansoni cpg binding protein 0.0032 0.0153 0.0241
Schistosoma mansoni hypothetical protein 0.0164 0.1054 0.167
Toxoplasma gondii fructose-bisphospatase II 0.0378 0.2514 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0455 0.0453
Brugia malayi TAR-binding protein 0.0322 0.2133 0.5128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0093 0.057 0.092
Brugia malayi MH1 domain containing protein 0.0041 0.0211 0.0505
Brugia malayi MH2 domain containing protein 0.0041 0.0211 0.0505
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0065 0.0128
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0458 0.1261
Echinococcus granulosus global transcription activator snf2l2 0.001 0.0004 0.0003
Echinococcus granulosus zinc finger protein 0.0031 0.0148 0.0147
Plasmodium falciparum importin beta, putative 0.0086 0.0519 1
Schistosoma mansoni hypothetical protein 0.0458 0.3057 0.4846
Loa Loa (eye worm) hypothetical protein 0.0049 0.027 0.0435
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.0707 0.0706
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0059 0.0058
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0049 0.027 0.0435
Echinococcus multilocularis G protein coupled receptor 139 0.0033 0.0161 0.0159
Onchocerca volvulus 0.0032 0.015 0.0313
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0058 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0161 0.0252
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1683 0.3545
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0093 0.057 0.1367
Schistosoma mansoni tar DNA-binding protein 0.0322 0.2133 0.3381
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0059 0.0139
Echinococcus granulosus bloom syndrome protein 0.002 0.0068 0.0067
Brugia malayi Serotonin receptor 0.0033 0.0161 0.0383
Schistosoma mansoni hypothetical protein 0.0915 0.6177 0.9797
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.0111 0.011
Onchocerca volvulus 0.0018 0.0059 0.0122
Loa Loa (eye worm) hypothetical protein 0.0093 0.057 0.092
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0161 0.0159
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0161 0.0159
Mycobacterium ulcerans lipase LipD 0.0077 0.0458 0.2408
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0099 0.0251
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0065 0.0152
Loa Loa (eye worm) hypothetical protein 0.0093 0.057 0.092
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0161 0.0159
Echinococcus multilocularis translational activator gcn1 0.0016 0.0045 0.0043
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0059 0.0058
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0059 0.0092
Echinococcus granulosus Bromodomain containing protein 0.001 0.0004 0.0003
Echinococcus multilocularis Bromodomain containing protein 0.001 0.0004 0.0003
Echinococcus multilocularis zinc finger protein 0.0031 0.0148 0.0147
Loa Loa (eye worm) hypothetical protein 0.0077 0.0458 0.0738
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0108 0.0674 0.1067
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0094 0.0578 0.2298
Loa Loa (eye worm) hypothetical protein 0.0044 0.0234 0.0376
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0033 0.0161 0.0383
Brugia malayi nuclear hormone receptor 0.0093 0.057 0.1367
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0004
Echinococcus multilocularis GPCR, family 2 0.0164 0.1054 0.1053
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0033 0.0161 0.0252
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Echinococcus multilocularis thyroid hormone receptor alpha 0.0093 0.057 0.0568
Mycobacterium leprae Probable lipase LipE 0.0077 0.0458 1
Brugia malayi beta-lactamase 0.0077 0.0458 0.1097
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.0011 0.0009
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0153 0.0246
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1082 0.2275
Schistosoma mansoni hypothetical protein 0.0355 0.2355 0.3733
Loa Loa (eye worm) G protein alpha subunit 3 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0049 0.027 0.0435
Loa Loa (eye worm) nuclear receptor NHR-67 0.0044 0.0234 0.0376
Trypanosoma cruzi Bromodomain, putative 0.001 0.0004 0.0007
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0184 0.1189 0.2507
Echinococcus granulosus glutamate receptor 2 0.0011 0.0009 0.0008
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0068 0.0135
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.001 0.0005 0.0008
Echinococcus granulosus snurportin 1 0.0915 0.6177 0.6177
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.1578 0.1576
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0033 0.0161 0.0252
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0065 0.1177
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0093 0.057 0.0901
Brugia malayi hypothetical protein 0.0053 0.0295 0.0706
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0005 0.0003
Echinococcus granulosus bromodomain containing protein 8 0.001 0.0004 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Schistosoma mansoni zinc finger protein 0.0044 0.0234 0.0369
Echinococcus multilocularis protein kinase C binding protein 1 0.001 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0164 0.1054 0.1705
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0059 0.0139
Trypanosoma brucei importin beta-1 subunit, putative 0.0086 0.0519 0.2051
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0458 0.0957
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0063 0.0365 0.1442
Onchocerca volvulus 0.0033 0.0161 0.0336
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1683 0.3545
Trypanosoma cruzi importin beta-1 subunit, putative 0.0069 0.0408 0.1616
Brugia malayi hypothetical protein 0.0082 0.0493 0.1182
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0092 0.0146
Mycobacterium tuberculosis Possible penicillin-binding protein 0.049 0.3278 1
Echinococcus multilocularis global transcription activator snf2l2 0.001 0.0004 0.0003
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0065 0.0265
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1683 0.3545
Echinococcus multilocularis nAChR subunit 0.0018 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0154 0.0988 0.0986
Echinococcus granulosus orexin receptor type 2 0.0033 0.0161 0.0159
Loa Loa (eye worm) hypothetical protein 0.0077 0.0458 0.0738
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0033 0.0161 0.0383
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1082 0.2275
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0161 0.0159
Plasmodium falciparum histone acetyltransferase GCN5 0.0084 0.0507 0.9776
Echinococcus multilocularis importin 5 0.0016 0.0045 0.0043
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0094 0.0578 0.1211
Brugia malayi RNA, U transporter 1 0.0244 0.1597 0.3839
Echinococcus multilocularis somatostatin receptor 0.0033 0.0161 0.0159
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0038 0.0037
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0033 0.0161 0.0159
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0093 0.057 0.1367
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0059 0.0058
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.005 0.0116
Echinococcus multilocularis ecdysone induced protein 78C 0.0093 0.057 0.0568
Onchocerca volvulus 0.001 0.0005 0.0007
Onchocerca volvulus 0.0018 0.0059 0.0122
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0033 0.0161 0.0159
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0059 0.0139
Schistosoma mansoni polybromo-1 0.001 0.0004 0.0004
Echinococcus multilocularis neuropeptide FF receptor 2 0.0033 0.0161 0.0159
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0068 0.0108
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0099 0.0377
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0033 0.0161 0.0383
Toxoplasma gondii fructose-bisphospatase I 0.0141 0.0893 0.3554
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0211 0.021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0049 0.027 0.0426
Echinococcus granulosus calpain 5 0.0044 0.0232 0.0231
Echinococcus multilocularis nuclear receptor nhr 48 0.0044 0.0234 0.0232
Brugia malayi hypothetical protein 0.0033 0.0161 0.0383
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0934 0.6305 1
Echinococcus granulosus importin subunit beta 1 0.0086 0.0519 0.0517
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0065 0.0063
Schistosoma mansoni cpg binding protein 0.0036 0.0181 0.0284
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0059 0.0094
Brugia malayi hypothetical protein 0.0106 0.0655 0.1571
Brugia malayi hypothetical protein 0.0033 0.0161 0.0383
Schistosoma mansoni cpg binding protein 0.0036 0.0181 0.0284
Echinococcus granulosus histone acetyltransferase KAT2B 0.0094 0.0578 0.0576
Loa Loa (eye worm) hypothetical protein 0.0057 0.0324 0.0523
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Trypanosoma brucei calpain-like protein, putative 0.0044 0.0232 0.0909
Schistosoma mansoni amine GPCR 0.0033 0.0161 0.0252
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0038 0.0037
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0059
Trichomonas vaginalis hypothetical protein 0.0016 0.0045 0.0085
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0234 0.0369
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0065 0.0103
Toxoplasma gondii histone lysine methyltransferase SET1 0.0074 0.0442 0.1758
Onchocerca volvulus 0.0033 0.0161 0.0336
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0161 0.0252
Schistosoma mansoni nuclear receptor nhr-48 0.0044 0.0234 0.0369
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.001 0.0005 0.0001
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0059 0.0058
Entamoeba histolytica bromodomain-containing protein 0.001 0.0004 0.0019
Brugia malayi calpain family protein 1 0.0147 0.0937 0.225
Entamoeba histolytica hypothetical protein 0.001 0.0002 0.0007
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0068 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0093 0.057 0.092
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0003 0.001
Trypanosoma brucei ISWI complex protein 0.0017 0.0051 0.0186
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0044 0.0234 0.049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0094
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0024 0.0023
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0059 0.0139
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0161 0.0159
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0011 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0077 0.0458 0.0738
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0065 0.0248
Schistosoma mansoni hypothetical protein 0.0033 0.0161 0.0252
Schistosoma mansoni intermediate filament proteins 0.0032 0.015 0.0235
Entamoeba histolytica recQ family DNA helicase 0.001 0.0003 0.0011
Loa Loa (eye worm) BRM protein 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0049 0.027 0.0435
Schistosoma mansoni ran 0.0063 0.0365 0.0576
Echinococcus granulosus Smad4 0.0041 0.0211 0.021
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0458 0.792
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0011 0.0012 0.0016
Trypanosoma brucei antigen, putative 0.0044 0.0232 0.0909
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0164 0.1054 0.2533
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0093 0.057 0.1367
Echinococcus granulosus dnaJ subfamily B 0.0458 0.3057 0.3055
Brugia malayi Cation transporter family protein 0.0018 0.0059 0.0139
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0161 0.0159
Leishmania major hypothetical protein, conserved 0.0077 0.0458 0.1806
Echinococcus multilocularis ATPase family AAA domain containing protein 2B 0.001 0.0004 0.0003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0458 0.1261
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0161 0.0159
Entamoeba histolytica hypothetical protein 0.0113 0.0707 0.3091
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0161 0.0159
Brugia malayi putative neuropeptide receptor 0.0033 0.0161 0.0383
Echinococcus multilocularis Smad4 0.0041 0.0211 0.021
Echinococcus granulosus CREB binding protein 0.001 0.0004 0.0003
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0161 0.0159
Loa Loa (eye worm) hypothetical protein 0.0032 0.015 0.024
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0211 0.021
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0037 0.0185 0.0183
Brugia malayi hypothetical protein 0.0033 0.0161 0.0383
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Plasmodium vivax bromodomain protein, putative 0.001 0.0004 0.0076
Brugia malayi MH1 domain containing protein 0.0041 0.0211 0.0505
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0416 0.1639
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0093 0.057 0.092
Schistosoma mansoni histamine h1 receptor 0.0033 0.0161 0.0252
Loa Loa (eye worm) nuclear factor I 0.0022 0.0088 0.0139
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.0004
Loa Loa (eye worm) calpain 5 0.0044 0.0232 0.0374
Echinococcus granulosus expressed protein 0.001 0.0005 0.0003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0093 0.057 0.0568
Loa Loa (eye worm) hypothetical protein 0.0103 0.0638 0.1031
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0049 0.027 0.0268
Onchocerca volvulus 0.001 0.0005 0.0007
Trypanosoma brucei importin beta-1 subunit, putative 0.0086 0.0519 0.2051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0034 0.0053
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0378 0.2514 1
Echinococcus multilocularis g-protein coupled receptor 0.0033 0.0161 0.0159
Onchocerca volvulus 0.0033 0.0161 0.0336
Brugia malayi hypothetical protein 0.0049 0.027 0.0646
Onchocerca volvulus 0.0033 0.0161 0.0336
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0258
Brugia malayi polybromodomain protein 0.001 0.0004 0.0007
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0044 0.0234 0.0369

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.5 uM Inhibition of human liver FBPase 1 ChEMBL. 20055427
IC50 (binding) = 4 uM Inhibition of rat liver FBPase 1 ChEMBL. 20055427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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