Detailed information for compound 1068929

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 367.807 | Formula: C15H14ClN3O4S
  • H donors: 3 H acceptors: 5 LogP: 0.97 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cc(c2c1ncnc2c1cscc1)Cl
  • InChi: 1S/C15H14ClN3O4S/c16-8-3-19(15-13(22)12(21)9(4-20)23-15)14-10(8)11(17-6-18-14)7-1-2-24-5-7/h1-3,5-6,9,12-13,15,20-22H,4H2/t9-,12-,13-,15-/m1/s1
  • InChiKey: QSYBJSCVFZWDHU-QGMIFYJMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine kinase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Echinococcus granulosus adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania infantum adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma cruzi adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania donovani adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Cryptosporidium parvum adenosine kinase like ribokinase Get druggable targets OG5_128398 All targets in OG5_128398
Candida albicans putative adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Candida albicans adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Neospora caninum GG10762, related Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania braziliensis adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Echinococcus multilocularis adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma congolense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Toxoplasma gondii kinase, pfkB family protein Get druggable targets OG5_128398 All targets in OG5_128398
Brugia malayi Adenosine kinase-like Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei gambiense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma japonicum ko:K00856 adenosine kinase [EC2.7.1.20], putative Get druggable targets OG5_128398 All targets in OG5_128398
Babesia bovis adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania mexicana adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma mansoni adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei gambiense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma mansoni adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania major adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Onchocerca volvulus Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma cruzi adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi adenosine kinase, putative adenosine kinase 345 aa 337 aa 35.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0106 0.0118
Echinococcus granulosus General substrate transporter 0.009 0.0798 0.089
Echinococcus multilocularis RUN 0.002 0.0084 0.0093
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.0948 0.3576
Toxoplasma gondii sugar transporter ST2 0.0015 0.0031 0.0099
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Schistosoma mansoni hypothetical protein 0.0034 0.0225 0.0251
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.012 0.0441
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0084 0.0119
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0043 0.0153
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0027 0.009
Onchocerca volvulus 0.0059 0.0481 0.0478
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0246 0.0919
Trypanosoma brucei ISWI complex protein 0.0018 0.0064 0.0233
Onchocerca volvulus Putative transporter 0.0015 0.0031 0.0029
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0208 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0106 0.0146
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0031 0.0408
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0332 0.0459
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0504 0.1733
Echinococcus multilocularis lamin dm0 0.0059 0.0481 0.0536
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0208 0.0288
Onchocerca volvulus 0.002 0.0084 0.0081
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0043 0.0048
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0026 0.0244
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0255 0.0952
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0027 0.009
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0014 0.0027 0.0386
Brugia malayi ecdysteroid receptor 0.0022 0.0106 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0031 0.0302
Loa Loa (eye worm) hypothetical protein 0.0083 0.0727 0.1443
Giardia lamblia Sugar-proton symporter 0.0015 0.0031 0.0108
Onchocerca volvulus 0.0104 0.0933 0.0931
Loa Loa (eye worm) sugar transporter 0.0105 0.0948 0.1882
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0043 0.0048
Echinococcus multilocularis solute carrier family 22 0.0015 0.0031 0.0035
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.0948 0.3268
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0027 0.0339
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Echinococcus multilocularis solute carrier family 22 0.0015 0.0031 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0246 0.2567
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0031 0.0408
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0201 0.0278
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0246 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0106 0.0146
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0969 0.1922
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0632 0.0704
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0043 0.0048
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0031 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0106 0.021
Brugia malayi major facilitator superfamily protein 0.0015 0.0031 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0332 0.037
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0106 0.0118
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0225 0.0251
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0208 0.0232
Schistosoma mansoni survival motor neuron protein 0.0104 0.0933 0.1041
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0014 0.0027 0.0386
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0246 0.0919
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0702 0.2646
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.1091 0.1217
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Schistosoma mansoni adenosine kinase 0.0105 0.0948 0.1057
Brugia malayi hypothetical protein 0.0015 0.0031 0.0043
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0014 0.0027 0.0386
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0208 0.0232
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0043 0.0153
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0255 0.0952
Plasmodium falciparum mitogen-activated protein kinase 2 0.017 0.1606 0.3595
Loa Loa (eye worm) hypothetical protein 0.0027 0.016 0.0317
Schistosoma mansoni rab6-interacting 0.002 0.0084 0.0093
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Entamoeba histolytica protein kinase, putative 0.0032 0.0208 0.2935
Echinococcus granulosus cpg binding protein 0.0069 0.0579 0.0645
Loa Loa (eye worm) hypothetical protein 0.0022 0.0106 0.021
Leishmania major glucose transporter, lmgt2 0.0033 0.0212 0.0793
Brugia malayi PHD-finger family protein 0.0033 0.0216 0.0298
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0106 0.0118
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0081 0.0702 0.7394
Trypanosoma brucei glucose transporter 2A 0.0033 0.0212 0.0793
Schistosoma mansoni hypothetical protein 0.0104 0.0933 0.1041
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0031 0.0302
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Echinococcus granulosus GPCR family 2 0.0034 0.0225 0.0251
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0702 0.2646
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0106 0.0103
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0027 0.009
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0043 0.0661
Brugia malayi hypothetical protein 0.008 0.069 0.0953
Trypanosoma cruzi ISWI complex protein 0.0018 0.0064 0.0233
Schistosoma mansoni zinc finger protein 0.0018 0.0064 0.0072
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.012 0.1669
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0031 0.0035
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.0948 0.3576
Plasmodium falciparum protein kinase 7 0.0297 0.2896 0.6542
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0225 0.0311
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0212 0.2215
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0085 0.0095
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0246 0.0919
Loa Loa (eye worm) hypothetical protein 0.0059 0.0481 0.0954
Loa Loa (eye worm) hypothetical protein 0.0027 0.016 0.0317
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0027 0.0053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0332 0.037
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0027 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0031 0.0302
Brugia malayi Bromodomain containing protein 0.0092 0.0815 0.1126
Echinococcus granulosus adenosine kinase 0.0105 0.0948 0.1057
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0202 0.028
Schistosoma mansoni zinc finger protein 0.0027 0.0152 0.0169
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0504 0.7171
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0081 0.0702 0.2416
Echinococcus granulosus survival motor neuron protein 1 0.0508 0.5039 0.5618
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0031 0.0062
Onchocerca volvulus 0.0015 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Brugia malayi nuclear hormone receptor 0.0022 0.0106 0.0146
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0212 0.0793
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Schistosoma mansoni glucose transport protein 0.0105 0.0948 0.1057
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0208 0.0404
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0027 0.009
Leishmania major telomerase reverse transcriptase, putative 0.0272 0.2645 1
Onchocerca volvulus 0.0015 0.0031 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0212 0.2215
Mycobacterium ulcerans sugar transporter 0.0015 0.0031 0.0408
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0014 0.0027 0.0386
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0255 0.051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0031 0.0302
Schistosoma mansoni hypothetical protein 0.0105 0.0948 0.1057
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0481 0.0954
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0084 0.0093
Echinococcus multilocularis neuropeptide receptor A26 0.0545 0.5412 0.6034
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0031 0.0099
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0093 0.0184
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1106 0.2195
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0208 0.0404
Onchocerca volvulus 0.0015 0.0031 0.0029
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0225 0.0251
Loa Loa (eye worm) hypothetical protein 0.008 0.069 0.1369
Schistosoma mansoni lipoxygenase 0.0083 0.0727 0.0811
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0081 0.0702 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0208 0.0777
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0332 0.037
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.0948 0.1057
Schistosoma mansoni adenosine kinase 0.0105 0.0948 0.1057
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0166
Schistosoma mansoni glucose transporter 0.0015 0.0031 0.0035
Brugia malayi Cytochrome P450 family protein 0.0053 0.0418 0.0578
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0225 0.0447
Toxoplasma gondii protein kinase, putative 0.0297 0.2896 1
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0031 0.0043
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0106 0.0118
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0504 0.0562
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.0948 0.1057
Echinococcus multilocularis fetal alzheimer antigen, falz 0.003 0.0187 0.0209
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0014 0.0027 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0212 0.2215
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.0948 0.1057
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0212 0.2215
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0027 0.0339
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.012 0.1903
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0027 0.003
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.0948 0.1057
Schistosoma mansoni ribokinase 0.0012 0.0003 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.004 0.0044
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0106 0.0118
Brugia malayi Cytochrome P450 family protein 0.0014 0.0027 0.0037
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0504 0.0562
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0031 0.0035
Toxoplasma gondii sugar transporter ST1 0.0015 0.0031 0.0099
Brugia malayi Adenosine kinase-like 0.0105 0.0948 0.131
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0225 0.0251
Echinococcus multilocularis General substrate transporter 0.009 0.0798 0.089
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0027 0.0339
Brugia malayi hypothetical protein 0.0508 0.5039 0.6963
Schistosoma mansoni inositol monophosphatase 0.0081 0.0702 0.0783
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0085 0.0095
Echinococcus multilocularis inositol monophosphatase 1 0.0081 0.0702 0.0783
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0208 0.0232
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0014 0.0027 0.0386
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0208 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1106 0.2195
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0128 0.0254
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0043 0.0048
Schistosoma mansoni polycystin 1-related 0.002 0.0084 0.0093
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0418 0.083
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0031 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0332 0.037
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0246 0.3472
Trypanosoma brucei adenosine kinase, putative 0.0105 0.0948 0.3576
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0043 0.014
Entamoeba histolytica hypothetical protein 0.0023 0.012 0.1669
Loa Loa (eye worm) hypothetical protein 0.0023 0.012 0.0237
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0014 0.0027 0.0339
Onchocerca volvulus 0.0015 0.0031 0.0029
Schistosoma mansoni inositol monophosphatase 0.0081 0.0702 0.0783
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0026 0.0244
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0006
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0027 0.009
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.012 0.0441
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Brugia malayi Telomerase reverse transcriptase 0.0725 0.7236 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Loa Loa (eye worm) doublecortin family protein 0.002 0.0084 0.0166
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0504 0.7171
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0201 0.0752
Giardia lamblia Telomerase catalytic subunit 0.0272 0.2645 1
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.012 0.0403
Leishmania major hypothetical protein, conserved 0.0018 0.0064 0.0233
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0014 0.0027 0.0386
Schistosoma mansoni lipoxygenase 0.0119 0.1091 0.1217
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0208 0.071
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0246 0.0274
Loa Loa (eye worm) hypothetical protein 0.0073 0.0625 0.124
Schistosoma mansoni cpg binding protein 0.0069 0.0579 0.0645
Schistosoma mansoni hypothetical protein 0.0034 0.0225 0.0251
Plasmodium vivax CDK-related protein kinase 6, putative 0.0446 0.441 1
Plasmodium falciparum telomerase reverse transcriptase 0.0272 0.2645 0.5969
Echinococcus multilocularis GPCR, family 2 0.0034 0.0225 0.0251
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0079 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0026 0.0244
Leishmania major cytochrome p450-like protein 0.0014 0.0027 0.009
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.017 0.1606 0.3595
Trypanosoma brucei adenosine kinase, putative 0.0105 0.0948 0.3576
Brugia malayi Inositol-1 0.0081 0.0702 0.097
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0084 0.1317
Schistosoma mansoni hypothetical protein 0.0018 0.0064 0.0072
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0099 0.0137
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0026 0.0244
Echinococcus granulosus fetal alzheimer antigen falz 0.003 0.0187 0.0209
Toxoplasma gondii kinase, pfkB family protein 0.0105 0.0948 0.3266
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0072 0.0616 1
Leishmania major glucose transporter, lmgt1 0.0033 0.0212 0.0793
Leishmania major cytochrome p450-like protein 0.0014 0.0027 0.009
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0246 0.0274
Schistosoma mansoni glucose transport protein 0.0105 0.0948 0.1057
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0014 0.0027 0.0386
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0014 0.0027 0.0386
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0106 0.0118
Onchocerca volvulus 0.0015 0.0031 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0014 0.0027 0.0386
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0043 0.006
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0208 0.0404
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0106 0.0118
Loa Loa (eye worm) hypothetical protein 0.0022 0.0106 0.021
Schistosoma mansoni sugar transporter 0.0015 0.0031 0.0035
Brugia malayi hypothetical protein 0.0051 0.0403 0.0557
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0246 0.0274
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0504 0.0562
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0106 0.0118
Brugia malayi hypothetical protein 0.0012 0.0003 0.0004
Echinococcus granulosus geminin 0.02 0.1908 0.2127
Brugia malayi CXXC zinc finger family protein 0.0063 0.0519 0.0718
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0043 0.0048
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0225 0.0251
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0099 0.0111
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0014 0.0027 0.0386
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0212 0.0793
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.017 0.1606 0.554
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0106 0.0118
Trichomonas vaginalis helicase, putative 0.0014 0.0026 0.0244
Brugia malayi Sugar transporter family protein 0.0015 0.0031 0.0043
Schistosoma mansoni hypothetical protein 0.0036 0.0244 0.0272
Loa Loa (eye worm) sugar transporter 0.0015 0.0031 0.0062
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.012 0.0133
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0504 0.7171
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0027 0.009
Loa Loa (eye worm) hypothetical protein 0.0107 0.0969 0.1922
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.0948 0.1057
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.0166
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0084 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0026 0.0244
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0246 0.0339
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0106 0.0118
Loa Loa (eye worm) hypothetical protein 0.0028 0.0171 0.0338
Plasmodium vivax ataxin-2 like protein, putative 0.008 0.069 0.1503
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0208 0.0232
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.004 0.0044
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0246 0.0274
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0171 0.019
Schistosoma mansoni sugar transporter 0.0015 0.0031 0.0035
Onchocerca volvulus 0.0015 0.0031 0.0029
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0106 0.0103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0026 0.0244
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0027 0.0339
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.082 0.8199 0.9142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0106 0.021
Loa Loa (eye worm) inositol-1 0.0081 0.0702 0.1393
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0106 0.0118
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.04
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.012 0.0441
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0031 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0106 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0106 0.0118
Schistosoma mansoni hypothetical protein 0.0014 0.0027 0.003
Echinococcus multilocularis lamin 0.0059 0.0481 0.0536
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0099 0.0111
Loa Loa (eye worm) hypothetical protein 0.0034 0.0225 0.0447
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0081 0.0702 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0031 0.0302
Plasmodium vivax hexose transporter 0.0105 0.0948 0.2094
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.009 0.0923
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0106 0.0146
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0272 0.2645 1
Echinococcus granulosus lamin dm0 0.0059 0.0481 0.0536
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0027 0.009
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0106 0.0118
Schistosoma mansoni protein kinase 0.0032 0.0208 0.0232
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0084 0.0093
Brugia malayi nuclear receptor NHR-88 0.0022 0.0106 0.0146
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0106 0.0118
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.003 0.0187 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0106 0.0146
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0255 0.051
Onchocerca volvulus 0.002 0.0084 0.0081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0084 0.1317
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0106 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Onchocerca volvulus 0.0093 0.0826 0.0824
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0625 0.0863
Loa Loa (eye worm) hypothetical protein 0.0508 0.5039 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0106 0.0118
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0072 0.0616 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0208 0.0413
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0246 0.0274
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0027 0.0339
Trypanosoma brucei glucose transporter, putative 0.0033 0.0212 0.0793
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0031 0.0108
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0106 0.0118
Echinococcus multilocularis geminin 0.02 0.1908 0.2127
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0027 0.0339
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0519 0.1031
Toxoplasma gondii sugar transporter ST3 0.0015 0.0031 0.0099
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0031 0.0465
Mycobacterium leprae putative cytochrome p450 0.0014 0.0027 0.0386
Toxoplasma gondii RNA-directed DNA polymerase 0.0272 0.2645 0.9133
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0027 0.0339
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0014 0.0027 0.0386
Onchocerca volvulus 0.0059 0.0481 0.0478
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Echinococcus granulosus intermediate filament protein 0.0059 0.0481 0.0536
Leishmania major protein kinase, putative 0.0032 0.0208 0.0777
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0106 0.021
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0212 0.0793
Brugia malayi intermediate filament protein 0.0059 0.0481 0.0664
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0027 0.0053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0106 0.0146
Onchocerca volvulus 0.0015 0.0031 0.0029
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0311 0.0347
Schistosoma mansoni hypothetical protein 0.002 0.0084 0.0093
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0014 0.0027 0.0386
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0027 0.0339
Trypanosoma brucei glucose transporter, putative 0.0033 0.0212 0.0793
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0027 0.0339
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0031 0.0108
Loa Loa (eye worm) hypothetical protein 0.0022 0.0106 0.021
Echinococcus granulosus dnaJ subfamily B 0.0896 0.8969 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0208 0.0404
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0031 0.0035
Leishmania major glucose transporter, lmgt3 0.0033 0.0212 0.0793
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0031 0.0062
Schistosoma mansoni hypothetical protein 0.0896 0.8969 1
Toxoplasma gondii LsmAD domain-containing protein 0.008 0.069 0.2374
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0084 0.0093
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0031 0.0035
Echinococcus granulosus solute carrier family 22 0.0015 0.0031 0.0035
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0043 0.0048
Plasmodium falciparum protein kinase 6 0.0446 0.441 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0133 0.1235 0.1377
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0026 0.0244
Brugia malayi Doublecortin family protein 0.002 0.0084 0.0116
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0212 0.0793
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0504 0.1897
Schistosoma mansoni cpg binding protein 0.0063 0.0519 0.0579
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0013 0.0025
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0208 0.0404
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0106 0.0118
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0012 0.0003 0.0003
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0201 0.0225
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0031 0.0035
Trypanosoma brucei glucose transporter, putative 0.0033 0.0212 0.0793
Trypanosoma brucei glucose transporter 1E 0.0033 0.0212 0.0793
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0027 0.0339
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0702 0.2646
Loa Loa (eye worm) hypothetical protein 0.0045 0.034 0.0675
Loa Loa (eye worm) hypothetical protein 0.0105 0.0948 0.1881
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0026 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0026 0.0244
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0081 0.0702 0.7394
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0969 0.1339
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.0948 0.1057
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.069 0.1503
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0246 0.0274
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0208 0.0232
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.1091 0.1217
Loa Loa (eye worm) hypothetical protein 0.0022 0.0106 0.021
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0188 0.0209
Plasmodium falciparum hexose transporter 0.0105 0.0948 0.2094
Brugia malayi Sugar transporter family protein 0.0015 0.0031 0.0043
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0031 0.0108
Schistosoma mansoni hypothetical protein 0.0034 0.0225 0.0251
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0208 0.0232
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0106 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0202 0.0402
Schistosoma mansoni cpg binding protein 0.0069 0.0579 0.0645
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0106 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0031 0.0302
Brugia malayi isocitrate dehydrogenase 0.0016 0.0043 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0026 0.0244
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.012 0.1669
Brugia malayi hypothetical protein 0.002 0.0084 0.0116
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0481 0.0954
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0027 0.0339
Schistosoma mansoni hypothetical protein 0.02 0.1908 0.2127
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0084 0.0093
Echinococcus multilocularis neuropeptide s receptor 0.0545 0.5412 0.6034
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0201 0.0225
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0106 0.021
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.0933 0.129
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0106 0.0146
Brugia malayi Cytochrome P450 family protein 0.0014 0.0027 0.0037
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.012 0.0201
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0027 0.0339
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0026 0.0244
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0014 0.0027 0.0386
Trypanosoma brucei glucose transporter, putative 0.0033 0.0212 0.0793
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0208 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0106 0.0146
Brugia malayi hypothetical protein 0.0015 0.0031 0.0043
Echinococcus multilocularis adenosine kinase 0.0105 0.0948 0.1057
Mycobacterium leprae Conserved hypothetical protein 0.0014 0.0027 0.0386
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0043 0.0086
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0106 0.0146
Brugia malayi Sugar transporter family protein 0.0105 0.0948 0.1311
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0106 0.0118
Trypanosoma cruzi hexose transporter 0.0033 0.0212 0.0793
Echinococcus granulosus solute carrier family 22 0.0015 0.0031 0.0035
Loa Loa (eye worm) hypothetical protein 0.0048 0.0369 0.0732
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.012 0.0441
Echinococcus granulosus zinc finger protein 0.0027 0.0152 0.0169
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0027 0.0339
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Echinococcus granulosus neuropeptide s receptor 0.0545 0.5412 0.6034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0099 0.0111
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0255 0.0952
Trypanosoma brucei glucose transporter, putative 0.0033 0.0212 0.0793
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0246 0.0919
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.012 0.1234
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0332 0.0659
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0106 0.021
Brugia malayi cytochrome P450 0.0014 0.0027 0.0037
Trypanosoma brucei glucose transporter, putative 0.0033 0.0212 0.0793
Echinococcus granulosus lamin 0.0059 0.0481 0.0536
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.0948 0.1057
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0106 0.0118
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0014 0.0027 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0026 0.0244
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0188 0.0209
Schistosoma mansoni hypothetical protein 0.0073 0.0625 0.0696
Onchocerca volvulus 0.0022 0.0106 0.0103
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0027 0.0339
Echinococcus granulosus neuropeptide receptor A26 0.0545 0.5412 0.6034
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0212 0.2215
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0504 0.0562
Onchocerca volvulus 0.0015 0.0031 0.0029
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0208 0.0232
Brugia malayi MH2 domain containing protein 0.0121 0.1106 0.1528
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.004 0.0044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0106 0.0118
Trypanosoma brucei glucose transporter, putative 0.0033 0.0212 0.0793
Trypanosoma brucei sugar transporter, putative 0.0015 0.0031 0.0108
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0201 0.0278
Loa Loa (eye worm) hypothetical protein 0.0032 0.0208 0.0413
Echinococcus multilocularis 0.0014 0.0027 0.003
Echinococcus granulosus ribokinase 0.0012 0.0003 0.0003
Onchocerca volvulus 0.0015 0.0031 0.0029
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0632 0.0704
Onchocerca volvulus 0.0015 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Schistosoma mansoni lamin 0.0059 0.0481 0.0536
Trypanosoma brucei glucose transporter, putative 0.0033 0.0212 0.0793
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0255 0.087
Leishmania major hypothetical protein, conserved 0.008 0.069 0.2599
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0106 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0106 0.0146
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0084 0.0093
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0225 0.0311
Brugia malayi hypothetical protein 0.0015 0.0031 0.0043
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0201 0.0225
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.069 0.2599
Brugia malayi Cam kinase protein 1 0.0032 0.0208 0.0288
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0255 0.0952
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0208 0.0404
Trypanosoma brucei telomerase reverse transcriptase 0.0272 0.2645 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0043 0.0048
Entamoeba histolytica protein kinase, putative 0.0032 0.0208 0.2935
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0332 0.037
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0208 0.0232
Onchocerca volvulus 0.0015 0.0031 0.0029
Trypanosoma cruzi ISWI complex protein 0.0018 0.0064 0.0233
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0031 0.0108
Echinococcus multilocularis ribokinase 0.0012 0.0003 0.0003
Trypanosoma brucei PAB1-binding protein , putative 0.008 0.069 0.2599
Schistosoma mansoni cytochrome P450 0.0014 0.0027 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0106 0.021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0332 0.037
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Echinococcus granulosus solute carrier family 22 0.0015 0.0031 0.0035
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0244 0.0272
Onchocerca volvulus 0.0015 0.0031 0.0029
Schistosoma mansoni protein kinase 0.0032 0.0208 0.0232
Echinococcus granulosus inositol monophosphatase 1 0.0081 0.0702 0.0783
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.012 0.5
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0031 0.0302
Onchocerca volvulus 0.0015 0.0031 0.0029
Onchocerca volvulus 0.0015 0.0031 0.0029
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.0948 0.1057
Echinococcus multilocularis cpg binding protein 0.0069 0.0579 0.0645
Loa Loa (eye worm) cytochrome P450 0.0014 0.0027 0.0053
Loa Loa (eye worm) hypothetical protein 0.0058 0.047 0.0932
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0084 0.0119
Schistosoma mansoni rab6-interacting 0.002 0.0084 0.0093
Echinococcus multilocularis dnaJ subfamily B 0.0896 0.8969 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0106 0.0146
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.069 0.2599
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0027 0.0053
Schistosoma mansoni hypothetical protein 0.02 0.1908 0.2127
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0702 0.2646
Leishmania major adenosine kinase, putative 0.0105 0.0948 0.3576
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0171 0.019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0106 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0026 0.0244
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0062 0.0225
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0027 0.0082
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0026 0.0244
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0212 0.2215
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0014 0.0027 0.0386
Schistosoma mansoni protein kinase 0.0032 0.0208 0.0232
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0246 0.0274
Schistosoma mansoni lamin 0.0059 0.0481 0.0536
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0043 0.0153
Schistosoma mansoni sugar transporter 0.0015 0.0031 0.0035
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.012 0.0133
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Loa Loa (eye worm) hypothetical protein 0.0032 0.0201 0.04
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0026 0.0244
Loa Loa (eye worm) hypothetical protein 0.0022 0.0106 0.021
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0255 0.0952
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0014 0.0027 0.0386
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0212 0.2215
Brugia malayi Ribokinase 0.0012 0.0003 0.0004
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.012 0.0133
Plasmodium vivax telomerase reverse transcriptase, putative 0.0272 0.2645 0.5969
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Brugia malayi Cytochrome P450 family protein 0.0014 0.0027 0.0037
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Loa Loa (eye worm) hypothetical protein 0.0036 0.0246 0.0487
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0027 0.0339
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0246 0.2567
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Brugia malayi Bromodomain containing protein 0.0045 0.0339 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Trichomonas vaginalis inositol monophosphatase, putative 0.0081 0.0702 0.7394
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0106 0.0118
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0027 0.0339
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0043 0.0153
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0106 0.0118
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0085 0.0095
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.004 0.0044
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0079 0.0156
Echinococcus multilocularis zinc finger protein 0.0027 0.0152 0.0169
Onchocerca volvulus 0.0015 0.0031 0.0029
Onchocerca volvulus 0.0015 0.0031 0.0029
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0027 0.0339
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0106 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Schistosoma mansoni hypothetical protein 0.0024 0.0128 0.0143
Loa Loa (eye worm) hypothetical protein 0.0022 0.0106 0.021
Giardia lamblia Hexose transporter 0.0015 0.0031 0.0108
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0208 0.071
Loa Loa (eye worm) hypothetical protein 0.0015 0.0031 0.0062
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0106 0.0118
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0106 0.0103
Echinococcus granulosus solute carrier family 22 0.0015 0.0031 0.0035
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0212 0.0793
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0208 0.0232
Loa Loa (eye worm) hypothetical protein 0.0026 0.0141 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0026 0.0244
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0208 0.071
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0043 0.014
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0201 0.3239
Schistosoma mansoni coup transcription factor 0.0022 0.0106 0.0118
Loa Loa (eye worm) hypothetical protein 0.0021 0.0099 0.0197
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0244 0.0272
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0027 0.0339
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.069 0.1503
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0027 0.0339
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0012 0.0003 0.0003
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0043 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0208 0.217
Schistosoma mansoni glucose transport protein 0.0105 0.0948 0.1057
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0014 0.0027 0.0386
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0201 0.0225
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0201 0.2841
Brugia malayi steroid hormone receptor 0.0022 0.0106 0.0146
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0027 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0106 0.021
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0085 0.0095
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0031 0.0302
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0106 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0084 0.1317
Leishmania major cytochrome p450-like protein 0.0014 0.0027 0.009
Loa Loa (eye worm) hypothetical protein 0.0054 0.0428 0.0849
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0106 0.021
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0014 0.0027 0.0386
Toxoplasma gondii histone lysine methyltransferase SET1 0.0122 0.1119 0.3856
Brugia malayi hypothetical protein 0.002 0.0084 0.0116
Echinococcus multilocularis solute carrier family 22 0.0015 0.0031 0.0035
Echinococcus multilocularis solute carrier family 22 0.0015 0.0031 0.0035
Schistosoma mansoni sugar transporter 0.0015 0.0031 0.0035
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0481 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0106 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0106 0.0118
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0014 0.0027 0.0386
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0948 1
Schistosoma mansoni loxhd1 0.002 0.0084 0.0093
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0106 0.021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0031 0.0302
Loa Loa (eye worm) hypothetical protein 0.0022 0.0106 0.021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0106 0.0146
Leishmania major hypothetical protein, conserved 0.0015 0.0031 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0026 0.0244
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0969 0.1339
Schistosoma mansoni bromodomain containing protein 0.0078 0.0675 0.0752
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0079 0.0088
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0081 0.0702 1
Echinococcus multilocularis survival motor neuron protein 1 0.0508 0.5039 0.5618
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0212 0.0793
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0201 0.2101
Onchocerca volvulus 0.0063 0.0519 0.0517
Schistosoma mansoni hypothetical protein 0.0034 0.0225 0.0251
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0106 0.0118
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.012 0.0201
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0272 0.2645 1
Brugia malayi lysyl-tRNA synthetase 0.0023 0.012 0.0165
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0043 0.0027
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.004 0.0044
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0504 0.8177
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0212 0.0793
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0043 0.0027
Schistosoma mansoni intermediate filament proteins 0.0059 0.0481 0.0536
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0332 0.037
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0031 0.0465
Echinococcus multilocularis musashi 0.0059 0.0481 0.0536
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0311 0.0347
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.012 0.0133
Echinococcus granulosus RUN 0.002 0.0084 0.0093
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0246 0.2567
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0208 0.0404
Brugia malayi major facilitator superfamily protein 0.0015 0.0031 0.0043
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0106 0.0118
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0099 0.0111
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0031 0.0043
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0246 0.0919

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 97 % Activity of human ADK assessed as compound conversion to 5'-phosphate form incubated at 37 degC for 20 mins by HPLC method ChEMBL. No reference
CC50 (ADMET) > 50 uM Cytotoxicity against human MRC5 cells after 72 hrs by MTT assay ChEMBL. No reference
GI50 (functional) = 0.018 uM Cytostatic activity against human DU145 cells after 5 days by SRB assay ChEMBL. 19929004
GI50 (functional) = 0.1 uM Cytostatic activity against human HCT116 cells after 5 days by SRB assay ChEMBL. 19929004
GI50 (functional) = 0.38 uM Cytostatic activity against human A549 cells after 5 days by SRB assay ChEMBL. 19929004
IC50 (functional) = 1 uM Cytotoxicity against human CCRF-CEM cells after 3 days by XTT assay ChEMBL. 19929004
IC50 (functional) = 1.6 uM Cytotoxicity against human HL60 cells after 3 days by XTT assay ChEMBL. 19929004
IC50 (binding) > 10 uM Inhibition of human ADK using [3H]-adenosine by scintillation counting method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19929004

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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