Detailed information for compound 1339056

Basic information

Technical information
  • TDR Targets ID: 1339056
  • Name: N-[3-(cyclopropylamino)-3-oxopropyl]-1-(4-flu orophenyl)sulfonylpiperidine-4-carboxamide
  • MW: 397.464 | Formula: C18H24FN3O4S
  • H donors: 2 H acceptors: 4 LogP: 0.74 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCN(CC1)S(=O)(=O)c1ccc(cc1)F)NCCC(=O)NC1CC1
  • InChi: 1S/C18H24FN3O4S/c19-14-1-5-16(6-2-14)27(25,26)22-11-8-13(9-12-22)18(24)20-10-7-17(23)21-15-3-4-15/h1-2,5-6,13,15H,3-4,7-12H2,(H,20,24)(H,21,23)
  • InChiKey: VGRPUNLQGGDFOU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(cyclopropylamino)-3-oxo-propyl]-1-(4-fluorophenyl)sulfonyl-piperidine-4-carboxamide
  • N-[3-(cyclopropylamino)-3-oxopropyl]-1-(4-fluorophenyl)sulfonyl-4-piperidinecarboxamide
  • N-[3-(cyclopropylamino)-3-keto-propyl]-1-(4-fluorophenyl)sulfonyl-isonipecotamide
  • ZINC06760815

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii protein kinase (incomplete catalytic triad) 0.0013 0.0015 0.1622
Plasmodium vivax tyrosine kinase-like protein, putative 0.0013 0.0015 0.1622
Toxoplasma gondii calcium-dependent protein kinase CDPK2 0.0013 0.0015 0.1622
Toxoplasma gondii CMGC kinase, MAPK family, MEK kinase-related (incomplete catalytic triad) 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Chlamydia trachomatis serine/threonine-protein kinase 0.0013 0.0015 0.5
Toxoplasma gondii exonuclease III APE 0.0023 0.0034 0.3728
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.009 0.1407
Toxoplasma gondii CMGC kinase, CDK family 0.0013 0.0015 0.1622
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0000000029691
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Onchocerca volvulus 0.0286 0.0551 1
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK-like 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK-frag 0.0013 0.0015 0.00000044241
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0057 0.0043
Toxoplasma gondii calcium-dependent protein kinase CDPK9 0.0013 0.0015 0.1622
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0034 1
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii NEK kinase 0.0013 0.0015 0.1622
Trichomonas vaginalis harmonin-interacting ankyrin-repeat containing protein (harp), sans, putative 0.0013 0.0015 0.00000005531
Toxoplasma gondii protein kinase (incomplete catalytic triad) 0.0013 0.0015 0.1622
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0034 0.0019
Toxoplasma gondii ULK kinase 0.0013 0.0015 0.1622
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0013 0.0015 0.1622
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK-like 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii rhoptry kinase family protein ROP39 0.0013 0.0015 0.1622
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0013 0.0015 0.1622
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.006 0.0045
Brugia malayi Pre-SET motif family protein 0.0251 0.0482 0.0469
Toxoplasma gondii rhoptry kinase family protein ROP37 (incomplete catalytic triad) 0.0013 0.0015 0.1622
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0034 1
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0013 0.0015 0.1622
Echinococcus granulosus MAP kinase activated protein kinase 2 0.5099 1 1
Toxoplasma gondii eIF2 kinase IF2K-D (incomplete catalytic triad) 0.0013 0.0015 0.1622
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0013 0.0015 0.5
Toxoplasma gondii protein kinase, putative 0.0013 0.0015 0.1622
Toxoplasma gondii ULK kinase 0.0013 0.0015 0.1622
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.5099 1 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0013 0.0015 0.1622
Plasmodium vivax protein kinase domain containing protein 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK-frag 0.0013 0.0015 0.00000044241
Plasmodium vivax glycogen synthase kinase 3, putative 0.0013 0.0015 0.1622
Toxoplasma gondii AGC kinase 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0015 0.1622
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0097 0.0083
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0013 0.0015 0.1622
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.006 0.0045
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0034 1
Toxoplasma gondii cell-cycle-associated protein kinase PRP4, putative 0.0013 0.0015 0.1622
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0034 0.0354
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.009 0.1407
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0034 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0013 0.0015 0.1622
Trichomonas vaginalis TKL family protein kinase 0.0013 0.0015 0.00000005531
Toxoplasma gondii calcium signaling protein kinase MARK, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, STE STE20 0.0013 0.0015 0.00000044241
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0034 0.0019
Toxoplasma gondii AGC kinase 0.0013 0.0015 0.1622
Plasmodium vivax unspecified product 0.0013 0.0015 0.1622
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0097 0.0083
Giardia lamblia Kinase, NEK-frag 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK-like 0.0013 0.0015 0.00000044241
Chlamydia trachomatis serine/threonine protein kinase 0.0013 0.0015 0.5
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0013 0.0015 0.1622
Toxoplasma gondii CMGC kinase, putative 0.0013 0.0015 0.1622
Toxoplasma gondii serine/threonine protein kinase AktR, putative 0.0013 0.0015 0.1622
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0015 0.1622
Toxoplasma gondii protein kinase (incomplete catalytic triad) 0.0013 0.0015 0.1622
Toxoplasma gondii cell-cycle-assocaited protein kinase ERK7, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii NEK kinase 0.0013 0.0015 0.1622
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0097 0.0083
Toxoplasma gondii hypothetical protein 0.0013 0.0015 0.1622
Trichomonas vaginalis TKL family protein kinase 0.0013 0.0015 0.00000005531
Toxoplasma gondii AGC kinase 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK-frag 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0013 0.0015 0.1622
Plasmodium vivax cdc2-like protein kinase, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0333 0.0318
Toxoplasma gondii cell-cycle-associated protein kinase DYRK, putative 0.0013 0.0015 0.1622
Toxoplasma gondii cAMP-dependent protein kinase 0.0013 0.0015 0.1622
Plasmodium vivax protein kinase, putative 0.0013 0.0015 0.1622
Toxoplasma gondii PEK kinase 0.0013 0.0015 0.1622
Toxoplasma gondii protein kinase 0.0013 0.0015 0.1622
Toxoplasma gondii cyclin-dependent kinase 0.0013 0.0015 0.1622
Brugia malayi Pre-SET motif family protein 0.0036 0.006 0.0045
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.006 0.6637
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0013 0.0015 0.1622
Toxoplasma gondii calcium-dependent protein kinase CDPK6 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0082 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.006 0.0045
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0013 0.0015 0.1622
Toxoplasma gondii protein kinase 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.009 1
Chlamydia trachomatis serine/threonine protein kinase 0.0013 0.0015 0.5
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Plasmodium vivax serine/threonine-specific protein kinase, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0013 0.0015 0.1622
Toxoplasma gondii protein kinase domain-containing protein 0.0013 0.0015 0.1622
Plasmodium vivax protein kinase, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii TBC domain-containing kinase (incomplete catalytic triad) 0.0013 0.0015 0.1622
Toxoplasma gondii CMGC kinase, CK2 family 0.0013 0.0015 0.1622
Mycobacterium leprae PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L) 0.0013 0.0015 0.5
Loa Loa (eye worm) acetyltransferase 0.0175 0.0333 0.0318
Toxoplasma gondii rhoptry kinase family protein ROP33 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii rhoptry kinase family protein ROP41 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii casein kinase I 0.0013 0.0015 0.1622
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0013 0.0015 0.1622
Toxoplasma gondii calcium signaling protein kinase RAD53, putative 0.0013 0.0015 0.1622
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0013 0.0015 0.1622
Toxoplasma gondii rhoptry kinase family protein ROP26 (incomplete catalytic triad) 0.0013 0.0015 0.1622
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0013 0.0015 0.1622
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A) 0.0013 0.0015 0.5
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0015 0.1622
Toxoplasma gondii CAM kinase, CDPK family 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii CAM kinase, SNF1/AMK1 family ToxPK1 0.0013 0.0015 0.1622
Toxoplasma gondii ULK kinase 0.0013 0.0015 0.1622
Toxoplasma gondii CAM Kinase family, incomplete catalytic triad 0.0013 0.0015 0.1622
Plasmodium vivax serine/threonine protein kinase, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii histone kinase SNF1, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK-frag 0.0013 0.0015 0.00000044241
Toxoplasma gondii rhoptry kinase family protein ROP28 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Plasmodium vivax calcium-dependent protein kinase, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii casein kinase I 0.0013 0.0015 0.1622
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0013 0.0015 0.0000000029691
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0082 1
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Plasmodium vivax protein kinase, putative 0.0013 0.0015 0.1622
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0034 1
Plasmodium vivax protein kinase domain containing protein 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0013 0.0015 0.1622
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.006 0.0045
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.009 1
Plasmodium vivax serine/threonine protein kinase, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0034 0.283
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0097 0.0083
Toxoplasma gondii rhoptry protein ROP16 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Plasmodium vivax serine/threonine-protein kinase Nek1, putative 0.0013 0.0015 0.1622
Trichomonas vaginalis TKL family protein kinase 0.0013 0.0015 0.00000005531
Giardia lamblia Kinase, NEK-like 0.0013 0.0015 0.00000044241
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0551 1
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0034 1
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Plasmodium vivax EKC/KEOPS complex subunit BUD32, putative 0.0013 0.0015 0.1622
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.006 0.0045
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.009 0.0076
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Plasmodium vivax serine/threonine protein kinase, putative 0.0013 0.0015 0.1622
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0013 0.0015 0.1622
Plasmodium vivax eukaryotic translation initiation factor 2-alpha kinase, putative 0.0013 0.0015 0.1622
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0013 0.0015 0.1622
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0097 0.0083
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii rhoptry kinase family protein ROP35 0.0013 0.0015 0.1622
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0013 0.0015 0.1622
Toxoplasma gondii myosin-light-chain kinase 0.0013 0.0015 0.1622
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0013 0.0015 0.1622
Plasmodium vivax cdc2-related protein kinase 1, putative 0.0013 0.0015 0.1622
Plasmodium vivax protein kinase, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.006 0.0045
Toxoplasma gondii protein kinase, putative 0.0013 0.0015 0.1622
Plasmodium vivax tyrosine kinase-like protein, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK-frag 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK-frag 0.0013 0.0015 0.00000044241
Plasmodium vivax protein kinase domain containing protein 0.0013 0.0015 0.1622
Toxoplasma gondii NEK kinase 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Plasmodium vivax calcium-dependent protein kinase 6, putative 0.0013 0.0015 0.1622
Plasmodium vivax serine/threonine protein kinase, putative 0.0013 0.0015 0.1622
Plasmodium vivax serine/threonine protein kinase VPS15, putative 0.0013 0.0015 0.1622
Toxoplasma gondii NEK kinase 0.0013 0.0015 0.1622
Plasmodium vivax protein kinase domain containing protein 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii rhoptry kinase family protein ROP34, putative 0.0013 0.0015 0.1622
Plasmodium vivax serine/threonine protein kinase, putative 0.0013 0.0015 0.1622
Plasmodium vivax mitogen-activated protein kinase 1, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK-frag 0.0013 0.0015 0.00000044241
Brugia malayi Protein kinase domain containing protein 0.0013 0.0015 0.0000000029691
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0013 0.0015 0.1622
Toxoplasma gondii protein kinase (incomplete catalytic triad) 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK-GL-like 0.0013 0.0015 0.00000044241
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Brugia malayi Protein kinase domain containing protein 0.0013 0.0015 0.0000000029691
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0013 0.0015 0.1622
Schistosoma mansoni ap endonuclease 0.0023 0.0034 0.0019
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0034 0.3728
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0034 0.5
Giardia lamblia Kinase, NEK-frag 0.0013 0.0015 0.00000044241
Plasmodium vivax serine/threonine kinase-1, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii rhoptry kinase family protein ROP46, putative 0.0013 0.0015 0.1622
Schistosoma mansoni serine/threonine protein kinase 0.5099 1 1
Toxoplasma gondii protein kinase, other 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK-frag 0.0013 0.0015 0.00000044241
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0013 0.0015 0.1622
Plasmodium vivax casein kinase 1, putative 0.0013 0.0015 0.1622
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK-frag 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii CMGC kinase 0.0013 0.0015 0.1622
Toxoplasma gondii eIF2 kinase IF2K-C 0.0013 0.0015 0.1622
Toxoplasma gondii calcium-dependent protein kinase 0.0013 0.0015 0.1622
Toxoplasma gondii aurora kinase 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii CMGC kinase, CK2 family 0.0013 0.0015 0.1622
Toxoplasma gondii protein kinase, putative 0.0013 0.0015 0.1622
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0013 0.0015 0.1622
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0082 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0013 0.0015 0.1622
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0097 0.0083
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Loa Loa (eye worm) hypothetical protein 0.0036 0.006 0.0045
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0034 0.0019
Toxoplasma gondii PIK3R4 kinase-related protein 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK-frag 0.0013 0.0015 0.00000044241
Toxoplasma gondii aurora kinase(incomplete catalytic triad) 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Plasmodium vivax SET domain protein, putative 0.0036 0.006 0.6637
Toxoplasma gondii NEK kinase 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii myosin-light-chain kinase 0.0013 0.0015 0.1622
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii atypical MEK-related kinase (incomplete catalytic triad) 0.0013 0.0015 0.1622
Plasmodium vivax protein kinase, putative 0.0013 0.0015 0.1622
Onchocerca volvulus 0.0036 0.006 0.0842
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Plasmodium vivax serine/threonine-protein kinase PRP4K, putative 0.0013 0.0015 0.1622
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0013 0.0015 0.1622
Toxoplasma gondii atypical MEK-related kinase (incomplete catalytic triad) 0.0013 0.0015 0.1622
Toxoplasma gondii AGC kinase 0.0013 0.0015 0.1622
Toxoplasma gondii cyclin-dependent kinase family 5 protein 0.0013 0.0015 0.1622
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0333 0.0318
Plasmodium vivax protein kinase Crk2 0.0013 0.0015 0.1622
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0323 0.0309
Plasmodium vivax serine/threonine-protein kinase Nek1, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii calcium-dependent protein kinase CDPK4 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii eIF2 kinase IF2K-A (incomplete catalytic triad) 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0013 0.0015 0.1622
Plasmodium vivax serine/threonine protein kinase, putative 0.0013 0.0015 0.1622
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.009 1
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0013 0.0015 0.1622
Toxoplasma gondii protein kinase, putative 0.0013 0.0015 0.1622
Toxoplasma gondii rhoptry kinase family protein ROP25 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii protein kinase, putative 0.0013 0.0015 0.1622
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0097 0.0083
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Plasmodium vivax protein kinase, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.006 0.0045
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0034 0.5
Toxoplasma gondii AGC kinase 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0097 0.0083
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0034 0.283
Plasmodium vivax serine/threonine protein kinase, FIKK family 0.0013 0.0015 0.1622
Toxoplasma gondii SCY kinase-related protein (incomplete catalytic triad) 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Plasmodium vivax serine/threonine protein kinase, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase 0.0013 0.0015 0.00000044241
Toxoplasma gondii rhoptry kinase family protein ROP27 0.0013 0.0015 0.1622
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0097 0.0083
Plasmodium vivax protein kinase, putative 0.0013 0.0015 0.1622
Toxoplasma gondii AGC kinase 0.0013 0.0015 0.1622
Toxoplasma gondii rhoptry kinase family protein ROP21 0.0013 0.0015 0.1622
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0034 0.283
Trichomonas vaginalis TKL family protein kinase 0.0013 0.0015 0.00000005531
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0013 0.0015 0.1622
Schistosoma mansoni ap endonuclease 0.0023 0.0034 0.0019
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii calcium-dependent protein kinase CDPK1 0.0013 0.0015 0.1622
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.5099 1 1
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii eIF2 kinase IF2K-B 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0013 0.0015 0.1622
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0034 0.0019
Plasmodium vivax 3-phosphoinositide dependent protein kinase-1, putative 0.0013 0.0015 0.1622
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0333 0.0318
Giardia lamblia Kinase, NEK-frag 0.0013 0.0015 0.00000044241
Toxoplasma gondii CMGC kinase 0.0013 0.0015 0.1622
Plasmodium vivax protein kinase domain containing protein 0.0013 0.0015 0.1622
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0013 0.0015 0.1622
Plasmodium vivax serine/threonine protein kinase, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii hypothetical protein 0.0013 0.0015 0.1622
Plasmodium vivax calcium-dependent protein kinase, putative 0.0013 0.0015 0.1622
Plasmodium vivax protein kinase domain containing protein 0.0013 0.0015 0.1622
Toxoplasma gondii CAM kinase, SNF1 family 0.0013 0.0015 0.1622
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0013 0.0015 0.1622
Plasmodium vivax serine/threonine-protein kinase NEK4, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Toxoplasma gondii protein kinase domain-containing protein 0.0013 0.0015 0.1622
Plasmodium vivax protein kinase, putative 0.0013 0.0015 0.1622
Plasmodium vivax CDK-related protein kinase 6, putative 0.0013 0.0015 0.1622
Toxoplasma gondii myosin-light-chain kinase 0.0013 0.0015 0.1622
Toxoplasma gondii histone kinase SNF1, putative 0.0013 0.0015 0.1622
Plasmodium vivax cyclin g-associated kinase, putative 0.0013 0.0015 0.1622
Toxoplasma gondii casein kinase I, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK-like 0.0013 0.0015 0.00000044241
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0034 0.0354
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0013 0.0015 0.1622
Plasmodium vivax serine/threonine-protein kinase 2, putative 0.0013 0.0015 0.1622
Toxoplasma gondii protein kinase (incomplete catalytic triad) 0.0013 0.0015 0.1622
Toxoplasma gondii Wee kinase 0.0013 0.0015 0.1622
Plasmodium vivax protein kinase, putative 0.0013 0.0015 0.1622
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0482 0.0469
Plasmodium vivax serine/threonine protein kinase, putative 0.0013 0.0015 0.1622
Giardia lamblia Kinase, NEK 0.0013 0.0015 0.00000044241

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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