Detailed information for compound 1343674

Basic information

Technical information
  • TDR Targets ID: 1343674
  • Name: (5-chloro-1-methyl-3-phenylpyrazol-4-yl)-[2-( trifluoromethyl)phenyl]methanol
  • MW: 366.765 | Formula: C18H14ClF3N2O
  • H donors: 1 H acceptors: 2 LogP: 4.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1nc(c(c1Cl)C(c1ccccc1C(F)(F)F)O)c1ccccc1
  • InChi: 1S/C18H14ClF3N2O/c1-24-17(19)14(15(23-24)11-7-3-2-4-8-11)16(25)12-9-5-6-10-13(12)18(20,21)22/h2-10,16,25H,1H3
  • InChiKey: JSFSSDXOQKVJHV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5-chloro-1-methyl-3-phenyl-pyrazol-4-yl)-[2-(trifluoromethyl)phenyl]methanol
  • (5-chloro-1-methyl-3-phenyl-4-pyrazolyl)-[2-(trifluoromethyl)phenyl]methanol
  • SMR000180616
  • 6K-526S
  • (5-chloro-1-methyl-3-phenyl-1H-pyrazol-4-yl)[2-(trifluoromethyl)phenyl]methanol
  • MLS000327605

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) SRC-1 0.0468 0.1311 0.13
Schistosoma mansoni tensin 0.0114 0.0024 0.0067
Onchocerca volvulus 0.0151 0.0157 0.0369
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0662 0.2018 0.2008
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0249 0.0517 0.2863
Echinococcus granulosus insulin receptor 0.085 0.2702 0.3855
Plasmodium falciparum calcium-dependent protein kinase 5 0.0207 0.0362 0.4376
Schistosoma mansoni vesicular amine transporter 0.0166 0.0213 0.0589
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0115 0.0028 0.0179
Echinococcus multilocularis calcium dependent protein kinase 0.0135 0.0101 0.0153
Brugia malayi SH2 domain containing protein 0.0114 0.0024 0.0012
Loa Loa (eye worm) hypothetical protein 0.0114 0.0024 0.0012
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0468 0.1311 0.2257
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0381 0.0995 0.0984
Entamoeba histolytica protein kinase, putative 0.0152 0.0163 0.0672
Schistosoma mansoni protein kinase 0.044 0.1211 0.3341
Echinococcus multilocularis mitogen activated protein kinase 14 0.0323 0.0784 0.134
Giardia lamblia Kinase, CMGC CK2 0.0205 0.0357 0.225
Echinococcus multilocularis 0.0114 0.0024 0.002
Trypanosoma brucei SNF1-related protein kinases, putative 0.0184 0.028 0.1548
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0436 0.1195 0.1695
Schistosoma mansoni tyrosine kinase 0.0629 0.1899 0.524
Echinococcus multilocularis serine threonine protein kinase 0.0422 0.1143 0.1965
Trichomonas vaginalis CMGC family protein kinase 0.0283 0.0638 0.3533
Entamoeba histolytica protein kinase, putative 0.0168 0.0222 0.0917
Schistosoma mansoni protein kinase 0.0134 0.0098 0.0272
Brugia malayi STAT protein, DNA binding domain containing protein 0.0114 0.0024 0.0012
Brugia malayi casein kinase 1, delta 0.0222 0.0419 0.0407
Echinococcus granulosus tyrosine protein kinase Srms 0.1022 0.3326 0.475
Echinococcus granulosus Protein kinase C brain isozyme 0.0505 0.1446 0.2055
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.0266 0.0735
Loa Loa (eye worm) hypothetical protein 0.0166 0.0213 0.0201
Schistosoma mansoni serine/threonine-protein kinase 0.0336 0.083 0.2292
Loa Loa (eye worm) CDC7 protein kinase 0.0307 0.0727 0.0715
Loa Loa (eye worm) hypothetical protein 0.0132 0.0089 0.0076
Schistosoma mansoni tensin 0.0114 0.0024 0.0067
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0348 0.0877 0.1239
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0505 0.1446 0.249
Entamoeba histolytica protein kinase, putative 0.0209 0.0372 0.1532
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0468 0.1311 0.13
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0318 0.0767 0.0755
Echinococcus granulosus mitogen activated protein kinase 3 0.0173 0.0239 0.0324
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0166 0.0213 0.0589
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0115 0.0028 0.0016
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0166 0.0213 0.0589
Trichomonas vaginalis CMGC family protein kinase 0.0335 0.0828 0.4584
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.014 0.0121 0.0188
Plasmodium falciparum serine/threonine protein kinase, putative 0.0296 0.0685 0.8274
Echinococcus granulosus protein kinase shaggy 0.0318 0.0767 0.1082
Entamoeba histolytica protein kinase domain containing protein 0.0296 0.0685 0.2825
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0114 0.0024 0.0017
Toxoplasma gondii AGC kinase 0.0317 0.0764 0.4385
Trichomonas vaginalis CAMK family protein kinase 0.0544 0.1588 0.8788
Schistosoma mansoni tyrosine kinase 0.0293 0.0675 0.1864
Brugia malayi cytokine inducible SH2-containing protein 5 0.0114 0.0024 0.0012
Giardia lamblia Kinase, CMGC GSK 0.0318 0.0767 0.4832
Loa Loa (eye worm) hypothetical protein 0.0184 0.028 0.0267
Echinococcus multilocularis epidermal growth factor receptor 0.0727 0.2253 0.3893
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0774 0.2426 0.2416
Loa Loa (eye worm) TK protein kinase 0.0272 0.06 0.0588
Trichomonas vaginalis STE family protein kinase 0.0177 0.0255 0.1413
Brugia malayi Variant SH3 domain containing protein 0.0196 0.0321 0.0309
Plasmodium falciparum casein kinase 1 0.0222 0.0419 0.5059
Brugia malayi SH2 domain containing protein 0.0114 0.0024 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0505 0.1446 0.399
Brugia malayi Sex muscle abnormal protein 5 0.0196 0.0321 0.0309
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0184 0.028 0.1762
Giardia lamblia Kinase, STE STE20 0.0177 0.0255 0.1608
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0468 0.1311 0.2257
Trypanosoma brucei cdc2-related kinase 3 0.0335 0.0828 0.4584
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0823 0.2604 0.3715
Schistosoma mansoni tyrosine kinase 0.0727 0.2253 0.6217
Entamoeba histolytica protein kinase, putative 0.0249 0.0517 0.2132
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Giardia lamblia Kinase, CMGC SRPK 0.0172 0.0234 0.1475
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0317 0.0764 0.9223
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0173 0.0239 0.1504
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0249 0.0517 0.0505
Trypanosoma cruzi casein kinase II, putative 0.0205 0.0357 0.225
Brugia malayi Protein kinase domain containing protein 0.0568 0.1675 0.1664
Loa Loa (eye worm) hypothetical protein 0.0285 0.0648 0.0636
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0222 0.0419 0.0407
Echinococcus granulosus casein kinase I gamma 0.043 0.1175 0.1667
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.034 0.0848 0.1451
Trichomonas vaginalis CAMK family protein kinase 0.0235 0.0465 0.2577
Plasmodium vivax protein kinase Crk2 0.0335 0.0828 1
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.079 0.2484 0.2474
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0727 0.2253 0.3211
Echinococcus granulosus serine:threonine protein kinase 0.0233 0.0458 0.0639
Schistosoma mansoni hypothetical protein 0.0114 0.0024 0.0067
Trypanosoma brucei Casein kinase II 0.0205 0.0357 0.1977
Loa Loa (eye worm) hypothetical protein 0.0114 0.0024 0.0012
Entamoeba histolytica protein kinase domain containing protein 0.0283 0.0638 0.2631
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0468 0.1311 0.2257
Loa Loa (eye worm) TK/FER protein kinase 0.0815 0.2572 0.2563
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0517 0.149 0.148
Loa Loa (eye worm) hypothetical protein 0.0645 0.1955 0.1945
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0869 0.2771 0.3954
Echinococcus granulosus epidermal growth factor receptor 0.0727 0.2253 0.3211
Schistosoma mansoni tensin-related 0.0114 0.0024 0.0067
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0317 0.0764 0.4811
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.1199 0.3972 0.3964
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.031 0.0739 0.4089
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0283 0.0638 0.3664
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0147 0.0145 0.0231
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0348 0.0877 0.1502
Echinococcus multilocularis rho associated protein kinase 0.0967 0.3127 0.5412
Echinococcus multilocularis myosin iiia 0.0175 0.0245 0.0405
Brugia malayi Tyrosine-protein kinase abl-1 0.0451 0.1249 0.1238
Brugia malayi map kinase activated protein kinase protein 2 0.079 0.2484 0.2474
Onchocerca volvulus 0.0284 0.0643 0.1714
Brugia malayi Immunoglobulin I-set domain containing protein 0.0535 0.1554 0.1544
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0172 0.0234 0.1475
Schistosoma mansoni protein kinase 0.0177 0.0255 0.0704
Echinococcus granulosus roundabout 2 0.0277 0.0616 0.0865
Brugia malayi SH2 domain containing protein 0.0815 0.2572 0.2563
Loa Loa (eye worm) hypothetical protein 0.0276 0.0614 0.0602
Schistosoma mansoni signal transduction protein lnk-related 0.0114 0.0024 0.0067
Loa Loa (eye worm) hypothetical protein 0.0367 0.0945 0.0934
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Loa Loa (eye worm) TK/ALK protein kinase 0.0568 0.1674 0.1664
Brugia malayi Protein kinase domain containing protein 0.0249 0.0517 0.0505
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0146 0.0402
Loa Loa (eye worm) hypothetical protein 0.0114 0.0024 0.0012
Giardia lamblia Kinase, AGC AKT 0.0239 0.048 0.3022
Schistosoma mansoni serine/threonine protein kinase 0.0508 0.1456 0.4017
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0168 0.0222 0.021
Trichomonas vaginalis CMGC family protein kinase 0.0205 0.0357 0.1977
Echinococcus granulosus dual specificity 0.0283 0.0638 0.0897
Brugia malayi Protein kinase domain containing protein 0.1051 0.3433 0.3425
Echinococcus granulosus protein kinase C gamma type 0.0422 0.1143 0.1621
Schistosoma mansoni serine/threonine protein kinase 0.0436 0.1195 0.3298
Loa Loa (eye worm) hypothetical protein 0.0616 0.1851 0.1841
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Schistosoma mansoni serine/threonine protein kinase 0.031 0.0739 0.2038
Echinococcus granulosus dual specificity protein kinase clk2 0.031 0.0739 0.1041
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0172 0.0234 0.0222
Echinococcus multilocularis titin 0.0146 0.0142 0.0224
Echinococcus multilocularis cyclin dependent kinase 0.0335 0.0828 0.1417
Schistosoma mansoni serine/threonine protein kinase 0.0275 0.0608 0.1679
Loa Loa (eye worm) hypothetical protein 0.0276 0.0614 0.0602
Brugia malayi Variant SH3 domain containing protein 0.0134 0.0098 0.0086
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0528 0.153 0.2175
Echinococcus granulosus serine:threonine protein kinase 0.0233 0.0458 0.0639
Loa Loa (eye worm) hypothetical protein 0.0276 0.0615 0.0604
Brugia malayi Kinase associated domain 1 family protein 0.0203 0.0347 0.0335
Schistosoma mansoni tyrosine kinase 0.0727 0.2253 0.6217
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0317 0.0764 0.1077
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0492 0.1398 0.2407
Brugia malayi Protein kinase domain containing protein 0.0168 0.0222 0.021
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0468 0.1311 0.2257
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0336 0.083 0.5231
Echinococcus multilocularis ephrin type A receptor 4 A 0.0225 0.0427 0.072
Entamoeba histolytica protein kinase, putative 0.0147 0.0146 0.06
Brugia malayi Stress-activated protein kinase jnk-1 0.0532 0.1544 0.1533
Brugia malayi putative serine/threonine kinase SADA gamma 0.0184 0.028 0.0267
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0169 0.0226 0.1249
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Loa Loa (eye worm) hypothetical protein 0.0203 0.0347 0.0335
Schistosoma mansoni serine/threonine protein kinase 0.043 0.1175 0.3243
Leishmania major protein kinase A catalytic subunit isoform 1 0.0317 0.0764 0.4811
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.0239 0.0659
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1051 0.3433 0.3425
Loa Loa (eye worm) TK/FER protein kinase 0.0211 0.0378 0.0366
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0306 0.0724 0.0712
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Echinococcus multilocularis dual specificity protein kinase clk2 0.031 0.0739 0.1262
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0317 0.0764 0.4228
Loa Loa (eye worm) hypothetical protein 0.0238 0.0477 0.0465
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0184 0.028 0.1762
Schistosoma mansoni growth factor receptor-bound protein 0.02 0.0336 0.0927
Loa Loa (eye worm) hypothetical protein 0.0178 0.0256 0.0243
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.079 0.2484 0.4294
Leishmania major protein kinase, putative 0.0207 0.0362 0.2283
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0989 0.3208 0.4581
Brugia malayi Variant SH3 domain containing protein 0.0197 0.0327 0.0314
Loa Loa (eye worm) TK protein kinase 0.0701 0.2158 0.2148
Schistosoma mansoni hypothetical protein 0.0114 0.0024 0.0067
Echinococcus multilocularis nervana 2 0.0246 0.0504 0.0854
Entamoeba histolytica protein kinase , putative 0.0296 0.0685 0.2825
Onchocerca volvulus 0.0307 0.0727 0.1947
Brugia malayi phosphoinositide-dependent protein kinase I 0.0168 0.0222 0.021
Schistosoma mansoni ste20-related kinase 0.0414 0.1117 0.3081
Schistosoma mansoni tyrosine kinase 0.085 0.2702 0.7456
Toxoplasma gondii histone kinase SNF1, putative 0.0184 0.028 0.1606
Loa Loa (eye worm) hypothetical protein 0.0237 0.047 0.0458
Echinococcus multilocularis dual specificity 0.0249 0.0517 0.0877
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0207 0.0362 0.4376
Trypanosoma cruzi cdc2-related kinase 3 0.0335 0.0828 0.5216
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0114 0.0024 0.002
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Trypanosoma cruzi cdc2-related kinase 1 0.0335 0.0828 0.5216
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0406 0.1085 0.1863
Trypanosoma brucei polo-like protein kinase 0.0544 0.1588 0.8788
Trichomonas vaginalis STE family protein kinase 0.0134 0.0098 0.0545
Plasmodium vivax serine/threonine kinase-1, putative 0.031 0.0739 0.892
Schistosoma mansoni serine/threonine protein kinase 0.1051 0.3433 0.9473
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0167 0.0219 0.2645
Echinococcus multilocularis serine:threonine protein kinase N2 0.0598 0.1785 0.308
Schistosoma mansoni serine/threonine protein kinase 0.0448 0.124 0.3422
Echinococcus granulosus protein tyrosine kinase 0.1104 0.3624 0.5177
Echinococcus granulosus cyclin dependent kinase 19 0.0204 0.0351 0.0485
Brugia malayi serine/threonine protein kinase 6 0.0296 0.0685 0.0674
Loa Loa (eye worm) hypothetical protein 0.0385 0.101 0.0999
Loa Loa (eye worm) hypothetical protein 0.0276 0.0615 0.0604
Onchocerca volvulus 0.0966 0.3122 0.8584
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0283 0.0638 0.0626
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0202 0.0346 0.0477
Loa Loa (eye worm) TK protein kinase 0.0535 0.1554 0.1544
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0406 0.1085 0.1074
Leishmania major protein kinase, putative 0.031 0.0739 0.4653
Schistosoma mansoni hypothetical protein 0.0203 0.0347 0.0957
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0296 0.0685 0.1169
Giardia lamblia Kinase, CDC7 0.0307 0.0727 0.4578
Leishmania major casein kinase II, putative 0.0205 0.0357 0.225
Schistosoma mansoni tyrosine kinase 0.0746 0.2321 0.6406
Onchocerca volvulus Tyrosine kinase homolog 0.1106 0.3633 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0114 0.0024 0.0012
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0508 0.1456 0.2508
Brugia malayi tRNA modification GTPase TrmE family protein 0.0114 0.0024 0.0012
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0114 0.0024 0.0067
Echinococcus granulosus serine threonine protein kinase nrc 0.0318 0.0766 0.108
Entamoeba histolytica protein kinase, putative 0.0147 0.0146 0.06
Loa Loa (eye worm) hypothetical protein 0.0114 0.0024 0.0012
Loa Loa (eye worm) hypothetical protein 0.0162 0.0199 0.0187
Loa Loa (eye worm) hypothetical protein 0.0166 0.0215 0.0203
Brugia malayi Protein kinase domain containing protein 0.0129 0.0081 0.0068
Brugia malayi Hr1 repeat family protein 0.0598 0.1785 0.1775
Echinococcus granulosus growth factor receptor bound protein 2 0.02 0.0336 0.0463
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0207 0.0362 0.0608
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0317 0.0764 0.4811
Plasmodium falciparum serine/threonine protein kinase 0.0172 0.0234 0.2828
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0468 0.1311 0.2257
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0207 0.0362 0.2081
Schistosoma mansoni rap gtpase-activating protein 0.0276 0.0615 0.1699
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Brugia malayi probable protein kinase 0.0717 0.2216 0.2206
Loa Loa (eye worm) SH2 domain-containing protein 0.0114 0.0024 0.0012
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0318 0.0766 0.108
Trichomonas vaginalis CAMK family protein kinase 0.0258 0.0547 0.3029
Plasmodium vivax casein kinase 1, putative 0.0222 0.0419 0.5059
Onchocerca volvulus 0.0211 0.0378 0.0981
Entamoeba histolytica protein kinase, putative 0.0172 0.0234 0.0965
Brugia malayi RhoGAP domain containing protein 0.0197 0.0327 0.0314
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Entamoeba histolytica casein kinase 1, putative 0.0222 0.0419 0.1727
Echinococcus granulosus suppressor of cytokine signaling 6 0.0114 0.0024 0.0017
Onchocerca volvulus 0.0318 0.0767 0.2058
Trichomonas vaginalis CMGC family protein kinase 0.0318 0.0767 0.4247
Echinococcus multilocularis serine:threonine protein kinase N2 0.034 0.0848 0.1451
Echinococcus multilocularis tyrosine kinase 0.0211 0.0378 0.0635
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0317 0.0764 0.4228
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0318 0.0766 0.9247
Echinococcus granulosus tyrosine protein kinase ABL1 0.0624 0.1878 0.2674
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0317 0.0764 0.9223
Giardia lamblia Kinase, CMGC CDK 0.0335 0.0828 0.5216
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0167 0.0219 0.1258
Echinococcus granulosus dual specificity 0.0283 0.0638 0.0897
Schistosoma mansoni tyrosine kinase 0.016 0.0191 0.0527
Entamoeba histolytica protein kinase, putative 0.0283 0.0638 0.2631
Brugia malayi Protein kinase domain containing protein 0.0406 0.1085 0.1074
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0294 0.068 0.1161
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0184 0.028 0.3378
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0169 0.0226 0.1421
Echinococcus granulosus tyrosine protein kinase Src64B 0.0468 0.1311 0.1862
Trichomonas vaginalis CMGC family protein kinase 0.0283 0.0638 0.3533
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0115 0.0028 0.0157
Echinococcus granulosus tyrosine protein kinase Fyn 0.0468 0.1311 0.1862
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0881 0.2815 0.4018
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0544 0.1588 1
Schistosoma mansoni serine/threonine protein kinase 0.0335 0.0828 0.2285
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0318 0.0767 0.2117
Entamoeba histolytica protein kinase, putative 0.0604 0.1806 0.7446
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0317 0.0764 0.4385
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.079 0.2483 0.4292
Schistosoma mansoni serine/threonine protein kinase 0.0317 0.0764 0.2108
Echinococcus granulosus tyrosine protein kinase Fyn 0.0468 0.1311 0.1862
Loa Loa (eye worm) TK/FER protein kinase 0.0211 0.0378 0.0366
Loa Loa (eye worm) hypothetical protein 0.0127 0.0073 0.006
Brugia malayi protein-tyrosine kinase 0.0386 0.1014 0.1003
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Trichomonas vaginalis CK1 family protein kinase 0.0222 0.0419 0.2319
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0774 0.2426 0.2416
Schistosoma mansoni tyrosine kinase 0.0629 0.1899 0.524
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0881 0.2815 0.487
Schistosoma mansoni serine/threonine protein kinase 0.079 0.2484 0.6854
Echinococcus granulosus hypothetical protein 0.0114 0.0024 0.0017
Onchocerca volvulus 0.0276 0.0614 0.1633
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0318 0.0767 0.0755
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0197 0.0327 0.0901
Trichomonas vaginalis CMGC family protein kinase 0.0173 0.0239 0.1322
Loa Loa (eye worm) AGC/NDR protein kinase 0.034 0.0848 0.0836
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.079 0.2483 0.2473
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0333 0.082 0.0808
Trichomonas vaginalis AGC family protein kinase 0.0381 0.0995 0.551
Echinococcus multilocularis Immunoglobulin 0.0166 0.0213 0.0349
Entamoeba histolytica protein kinase domain containing protein 0.0205 0.0357 0.1472
Echinococcus multilocularis tyrosine protein kinase Blk 0.0386 0.1014 0.174
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0323 0.0784 0.4938
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0276 0.0615 0.3877
Brugia malayi hypothetical protein 0.0211 0.0378 0.0366
Brugia malayi p70 ribosomal S6 kinase beta 0.0586 0.1742 0.1731
Loa Loa (eye worm) TK protein kinase 0.0574 0.1698 0.1687
Toxoplasma gondii AGC kinase 0.0317 0.0764 0.4385
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0448 0.124 0.2133
Brugia malayi SH2 domain containing protein 0.0211 0.0378 0.0366
Echinococcus granulosus tyrosine protein kinase Blk 0.0386 0.1014 0.1436
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0147 0.0146 0.0191
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.028 0.0772
Schistosoma mansoni titin 0.0146 0.0142 0.0391
Brugia malayi Protein kinase domain containing protein 0.0604 0.1806 0.1796
Schistosoma mansoni tyrosine kinase 0.1104 0.3624 1
Schistosoma mansoni serine/threonine protein kinase 0.0967 0.3127 0.863
Schistosoma mansoni serine/threonine protein kinase 0.0296 0.0685 0.1891
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0532 0.1544 0.1533
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0645 0.1955 0.2784
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0439 0.1207 0.1196
Echinococcus multilocularis Immunoglobulin 0.0166 0.0213 0.0349
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0426 0.1159 0.1148
Echinococcus multilocularis protein kinase shaggy 0.0318 0.0767 0.1311
Brugia malayi Protein kinase domain containing protein 0.039 0.1027 0.1016
Plasmodium falciparum calcium-dependent protein kinase 3 0.0207 0.0362 0.4376
Trypanosoma cruzi polo-like protein kinase, putative 0.0544 0.1588 1
Giardia lamblia Kinase, CMGC CDK 0.0335 0.0828 0.5216
Echinococcus granulosus serine:threonine protein kinase N2 0.0258 0.0548 0.0767
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2857 1 1
Entamoeba histolytica protein kinase, putative 0.0172 0.0234 0.0965
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.044 0.1211 0.12
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0111 0.0013 0.0035
Brugia malayi MAP kinase sur-1 0.0173 0.0239 0.0226
Echinococcus multilocularis casein kinase I alpha 0.0222 0.0419 0.0706
Schistosoma mansoni tyrosine kinase 0.0177 0.0253 0.0699
Giardia lamblia Kinase, STE STE20 0.0175 0.0245 0.1546
Loa Loa (eye worm) hypothetical protein 0.0233 0.0458 0.0446
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0114 0.0024 0.002
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.1051 0.3433 0.5943
Brugia malayi C1-like domain containing protein 0.0439 0.1207 0.1196
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0169 0.0226 0.1421
Loa Loa (eye worm) hypothetical protein 0.0197 0.0327 0.0314
Schistosoma mansoni protein kinase 0.0169 0.0226 0.0622
Echinococcus multilocularis serine:threonine protein kinase 0.0233 0.0458 0.0775
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Giardia lamblia Kinase, PLK 0.0544 0.1588 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0293 0.0675 0.1151
Onchocerca volvulus 0.0222 0.0419 0.1094
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0249 0.0517 0.3258
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.034 0.0848 0.1197
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0283 0.0638 0.0626
Brugia malayi Tensin 0.0114 0.0024 0.0012
Plasmodium falciparum glycogen synthase kinase 3 0.0318 0.0767 0.9263
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0175 0.0245 0.1012
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0508 0.1456 0.2069
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0318 0.0767 0.4832
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0436 0.1195 0.1695
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Trichomonas vaginalis CMGC family protein kinase 0.0307 0.0727 0.4023
Trichomonas vaginalis STE family protein kinase 0.0277 0.0618 0.3419
Echinococcus granulosus expressed protein 0.0172 0.0234 0.0318
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0114 0.0024 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.0234 0.0646
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0528 0.153 0.2637
Brugia malayi Protein kinase domain containing protein 0.0392 0.1034 0.1023
Schistosoma mansoni protein kinase 0.0296 0.0685 0.1891
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0175 0.0245 0.1012
Entamoeba histolytica protein kinase, putative 0.0186 0.0286 0.1178
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0436 0.1195 0.2055
Echinococcus granulosus dual specificity 0.0283 0.0638 0.0897
Onchocerca volvulus 0.0967 0.3127 0.8598
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0207 0.0362 0.0502
Brugia malayi Temporarily assigned gene name protein 59 0.0276 0.0615 0.0604
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0544 0.1588 0.2737
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Brugia malayi Protein kinase domain containing protein 0.034 0.0848 0.0836
Trichomonas vaginalis AGC family protein kinase 0.0604 0.1806 1
Trichomonas vaginalis AGC family protein kinase 0.0168 0.0222 0.1231
Entamoeba histolytica protein kinase, putative 0.0296 0.0685 0.2825
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0439 0.1207 0.1196
Brugia malayi Protein kinase domain containing protein 0.043 0.1175 0.1164
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0335 0.0828 0.0817
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0166 0.0213 0.0349
Echinococcus granulosus dual specificity 0.0249 0.0517 0.0723
Schistosoma mansoni serine/threonine protein kinase 0.0532 0.1544 0.4261
Loa Loa (eye worm) hypothetical protein 0.1199 0.3972 0.3964
Leishmania major protein kinase A catalytic subunit isoform 2 0.0317 0.0764 0.4811
Loa Loa (eye worm) thyroid receptor interactor 0.0233 0.0456 0.0444
Echinococcus granulosus NCK adaptor protein 0.0196 0.0321 0.0443
Trypanosoma cruzi casein kinase, putative 0.0222 0.0419 0.2639
Entamoeba histolytica cell division protein kinase 2, putative 0.0335 0.0828 0.3414
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0175 0.0245 0.1358
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0774 0.2426 0.4193
Brugia malayi P38 map kinase family protein 2 0.0323 0.0784 0.0772
Schistosoma mansoni serine/threonine protein kinase 0.034 0.0848 0.2339
Entamoeba histolytica protein kinase domain containing protein 0.0249 0.0517 0.2132
Loa Loa (eye worm) hypothetical protein 0.0276 0.0614 0.0602
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.031 0.0739 0.4653
Loa Loa (eye worm) hypothetical protein 0.0245 0.0503 0.0491
Schistosoma mansoni hypothetical protein 0.0276 0.0615 0.1699
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0317 0.0764 0.4811
Brugia malayi Protein kinase c protein 2 0.0236 0.047 0.0458
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.1051 0.3433 0.9445
Onchocerca volvulus 0.0211 0.0378 0.0981
Entamoeba histolytica SH2 domain containing protein 0.0114 0.0024 0.01
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.0113 0.0019 0.0108
Schistosoma mansoni protein kinase 0.079 0.2483 0.6851
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0294 0.068 0.0957
Echinococcus multilocularis cyclin dependent kinase 1 0.0335 0.0828 0.1417
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.031 0.0739 0.4241
Trichomonas vaginalis CMGC family protein kinase 0.0205 0.0357 0.1977
Loa Loa (eye worm) AGC/PKA protein kinase 0.0317 0.0764 0.0752
Entamoeba histolytica protein kinase, putative 0.0177 0.0255 0.1052
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0296 0.0685 0.8274
Schistosoma mansoni protein kinase 0.0322 0.0781 0.2155
Echinococcus multilocularis tyrosine protein kinase shark 0.0636 0.1922 0.3318
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0276 0.0615 0.1048
Schistosoma mansoni nephrin 0.0111 0.0013 0.0035
Plasmodium vivax unspecified product 0.0205 0.0357 0.4313
Echinococcus granulosus cGMP dependent protein kinase 1 0.0274 0.0606 0.0851
Entamoeba histolytica PH domain containing protein kinase, putative 0.0335 0.0828 0.3415
Entamoeba histolytica protein kinase, putative 0.0272 0.06 0.2473
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0177 0.0255 0.0348
Echinococcus multilocularis casein kinase I alpha 0.0222 0.0419 0.0706
Trichomonas vaginalis AGC family protein kinase 0.0296 0.0685 0.3793
Echinococcus granulosus aurora kinase A 0.0296 0.0685 0.0964
Echinococcus multilocularis rac serine:threonine kinase 0.0336 0.083 0.1421
Trichomonas vaginalis CK1 family protein kinase 0.0222 0.0419 0.2319
Trichomonas vaginalis STE family protein kinase 0.0177 0.0255 0.1413
Onchocerca volvulus Serine\/threonine kinase homolog 0.0333 0.082 0.2204
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Schistosoma mansoni tyrosine kinase 0.051 0.1464 0.4039
Schistosoma mansoni serine/threonine protein kinase 0.0436 0.1195 0.3298
Plasmodium falciparum NIMA related kinase 1 0.0277 0.0618 0.7459
Toxoplasma gondii aurora kinase 0.0296 0.0685 0.3934
Echinococcus multilocularis expressed protein 0.0172 0.0234 0.0385
Trichomonas vaginalis CMGC family protein kinase 0.0205 0.0357 0.1977
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0235 0.0465 0.0787
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0468 0.1311 0.1862
Echinococcus multilocularis tyrosine protein kinase HCK 0.0272 0.06 0.1021
Echinococcus granulosus calcium dependent protein kinase 0.0135 0.0101 0.0127
Loa Loa (eye worm) hypothetical protein 0.0255 0.0537 0.0526
Echinococcus granulosus Vam6:Vps39 protein 0.0276 0.0615 0.0864
Schistosoma mansoni tyrosine kinase 0.1071 0.3504 0.967
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0276 0.0615 0.3407
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Schistosoma mansoni adapter molecule crk 0.0196 0.0321 0.0887
Giardia lamblia Kinase, CMGC GSK 0.0318 0.0767 0.4832
Trypanosoma brucei rac serine-threonine kinase, putative 0.0604 0.1806 1
Echinococcus multilocularis serine:threonine protein kinase 38 0.034 0.0848 0.1451
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Echinococcus multilocularis N chimaerin 0.0197 0.0327 0.0546
Trichomonas vaginalis CMGC family protein kinase 0.0205 0.0357 0.1977
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0207 0.0362 0.035
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0317 0.0764 0.1077
Giardia lamblia Kinase, CAMK CAMKL 0.0184 0.028 0.1762
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.028 0.0772
Echinococcus multilocularis death associated protein kinase 1 0.1693 0.5767 1
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0184 0.028 0.1762
Schistosoma mansoni tyrosine kinase 0.0468 0.1311 0.3619
Entamoeba histolytica serine/threonine protein kinase, putative 0.0544 0.1588 0.6544
Schistosoma mansoni suppressor of cytokine signaling 0.0114 0.0024 0.0067
Schistosoma mansoni GTPase activating protein 0.0114 0.0024 0.0067
Echinococcus multilocularis nervana 2 0.0246 0.0504 0.0854
Schistosoma mansoni serine/threonine kinase 0.0438 0.1202 0.3317
Brugia malayi casein kinase I 0.0222 0.0419 0.0407
Echinococcus granulosus hypothetical protein 0.0238 0.0477 0.0666
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.013 0.0084 0.0465
Schistosoma mansoni serine/threonine protein kinase 0.031 0.0739 0.2038
Leishmania major protein kinase, putative 0.0175 0.0245 0.1546
Schistosoma mansoni growth factor receptor-bound protein 0.0196 0.0321 0.0887
Schistosoma mansoni serine/threonine protein kinase 0.0528 0.153 0.4222
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0147 0.0146 0.0231
Loa Loa (eye worm) TK/EPH protein kinase 0.026 0.0554 0.0542
Echinococcus multilocularis neuroglian 0.0209 0.037 0.0621
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0257 0.0544 0.3429
Loa Loa (eye worm) AUR protein kinase 0.0296 0.0685 0.0674
Echinococcus granulosus casein kinase I alpha 0.0222 0.0419 0.0583
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0296 0.0685 0.2825
Trypanosoma cruzi casein kinase, putative 0.0222 0.0419 0.2639
Loa Loa (eye worm) AGC/PKN protein kinase 0.0598 0.1785 0.1775
Onchocerca volvulus Serine\/threonine kinase homolog 0.0544 0.1588 0.4332
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0296 0.0685 0.0964
Echinococcus multilocularis casein kinase ii subunit alpha 0.0205 0.0357 0.0599
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0492 0.1398 0.2407
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0205 0.0357 0.0345
Trichomonas vaginalis AGC family protein kinase 0.0296 0.0685 0.3793
Echinococcus granulosus twitchin 0.0281 0.0632 0.0888
Schistosoma mansoni protein kinase 0.0869 0.2771 0.7646
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0662 0.2018 0.2008
Echinococcus granulosus cyclin dependent kinase 0.0335 0.0828 0.1169
Echinococcus granulosus tyrosine protein kinase 0.0574 0.1698 0.2416
Trichomonas vaginalis CMGC family protein kinase 0.0307 0.0727 0.4023
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0207 0.0362 0.4376
Echinococcus granulosus SHC transforming protein 3 0.0114 0.0024 0.0017
Trypanosoma cruzi polo-like protein kinase, putative 0.0544 0.1588 1
Echinococcus multilocularis 0.0299 0.0696 0.1188
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.028 0.0772
Onchocerca volvulus 0.0211 0.0378 0.0981
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0468 0.1311 0.1862
Loa Loa (eye worm) TK protein kinase 0.0386 0.1014 0.1003
Echinococcus granulosus Immunoglobulin 0.0166 0.0213 0.0288
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0317 0.0764 0.1305
Giardia lamblia Aurora kinase 0.0296 0.0685 0.4316
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0318 0.0767 0.4832
Leishmania major protein kinase A catalytic subunit 0.0317 0.0764 0.4811
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0184 0.028 0.0464
Brugia malayi protein unc-22 0.0146 0.0142 0.0129
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0277 0.0618 0.7459
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0532 0.1544 0.2661
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0544 0.1588 0.1577
Echinococcus multilocularis growth factor receptor bound protein 2 0.0196 0.0321 0.0537
Trichomonas vaginalis CMGC family protein kinase 0.0335 0.0828 0.4584
Echinococcus multilocularis mitogen activated protein kinase 14 0.0323 0.0784 0.134
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0222 0.0614
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0317 0.0764 0.0752
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Echinococcus multilocularis cyclin dependent kinase 1 0.0335 0.0828 0.1417
Entamoeba histolytica p21-activated kinase 0.0195 0.032 0.1318
Brugia malayi Immunoglobulin I-set domain containing protein 0.0197 0.0327 0.0314
Trichomonas vaginalis AGC family protein kinase 0.0604 0.1806 1
Onchocerca volvulus 0.0895 0.2866 0.7873
Schistosoma mansoni serine/threonine protein kinase 0.0274 0.0606 0.1674
Echinococcus multilocularis protein kinase c epsilon type 0.0426 0.1159 0.1992
Toxoplasma gondii AGC kinase 0.0586 0.1742 1
Brugia malayi Protein kinase domain containing protein 0.031 0.0739 0.0727
Loa Loa (eye worm) hypothetical protein 0.0717 0.2218 0.2208
Trichomonas vaginalis STE family protein kinase 0.0177 0.0255 0.1413
Trypanosoma brucei protein kinase, putative 0.0173 0.0239 0.1322
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0197 0.0327 0.0314
Echinococcus granulosus tyrosine protein kinase Lyn 0.054 0.1573 0.2237
Entamoeba histolytica protein kinase, putative 0.0249 0.0517 0.2132
Echinococcus multilocularis dual specificity 0.0283 0.0638 0.1087
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0172 0.0234 0.1344
Loa Loa (eye worm) hypothetical protein 0.0211 0.0378 0.0366
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.031 0.0739 0.4653
Trypanosoma cruzi p21-activated kinase 3, putative 0.0115 0.0028 0.0179
Echinococcus multilocularis c src tyrosine kinase 0.0293 0.0675 0.1152
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0283 0.0638 0.402
Entamoeba histolytica protein kinase, putative 0.0152 0.0163 0.0672
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0115 0.0028 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.0307 0.0727 0.2006
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0322 0.0781 0.1102
Loa Loa (eye worm) SH2 domain-containing protein 0.0114 0.0024 0.0012
Schistosoma mansoni protein kinase 0.0222 0.0419 0.1156
Entamoeba histolytica PH domain containing protein kinase, putative 0.0336 0.083 0.3423
Echinococcus multilocularis tyrosine protein kinase Srms 0.0386 0.1014 0.174
Schistosoma mansoni protein kinase 0.039 0.1027 0.2835
Schistosoma mansoni ephrin receptor 0.0225 0.0427 0.1178
Plasmodium falciparum protein kinase, putative 0.0169 0.0226 0.2723
Echinococcus multilocularis NCK adaptor protein 0.02 0.0336 0.0562
Onchocerca volvulus 0.0211 0.0378 0.0981
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0177 0.0255 0.0422
Brugia malayi ephrin receptor 1 precursor 0.0157 0.0182 0.017
Echinococcus granulosus raf serine:threonine protein kinase 0.0181 0.0266 0.0364
Plasmodium falciparum calcium-dependent protein kinase 2 0.0207 0.0362 0.4376
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0142 0.0391
Brugia malayi Protein kinase domain containing protein 0.0898 0.2877 0.2868
Trichomonas vaginalis AGC family protein kinase 0.0277 0.0618 0.3419
Brugia malayi Protein kinase domain containing protein 0.0211 0.0378 0.0366
Entamoeba histolytica protein kinase domain containing protein 0.0774 0.2426 1
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0168 0.0222 0.0301
Echinococcus multilocularis casein kinase I alpha 0.0222 0.0419 0.0706
Onchocerca volvulus 0.0146 0.0142 0.0326
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0317 0.0764 0.1077
Echinococcus multilocularis calcium activated potassium channel 0.0275 0.0608 0.1035
Schistosoma mansoni serine/threonine kinase 0.034 0.0848 0.2339
Echinococcus granulosus serine:threonine protein kinase N2 0.0598 0.1785 0.2541
Entamoeba histolytica hypothetical protein 0.0756 0.2358 0.9721
Echinococcus multilocularis casein kinase I gamma 0.043 0.1175 0.202
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0323 0.0784 0.4938
Loa Loa (eye worm) STAT protein 0.0114 0.0024 0.0012
Trichomonas vaginalis CMGC family protein kinase 0.0283 0.0638 0.3533
Echinococcus granulosus tyrosine protein kinase Src42A 0.0293 0.0675 0.0949
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0175 0.0245 0.1546
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0898 0.2877 0.2868
Echinococcus multilocularis twitchin 0.0115 0.0029 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0604 0.1806 1
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.079 0.2483 0.3541
Brugia malayi Doublecortin family protein 0.0306 0.0724 0.0712
Trichomonas vaginalis STE family protein kinase 0.0175 0.0245 0.1358
Brugia malayi Variant SH3 domain containing protein 0.0196 0.0321 0.0309
Echinococcus granulosus c src tyrosine kinase 0.0293 0.0675 0.095
Echinococcus granulosus cGMP dependent protein kinase 1 0.0274 0.0606 0.0851
Echinococcus multilocularis casein kinase I delta 0.0222 0.0419 0.0706
Loa Loa (eye worm) TK/INSR protein kinase 0.085 0.2702 0.2693
Brugia malayi STE20-like kinase MST 0.0517 0.149 0.148
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0153 0.0167 0.0155
Loa Loa (eye worm) TK/FER protein kinase 0.0211 0.0378 0.0366
Echinococcus granulosus mitogen activated protein kinase 14 0.0323 0.0784 0.1106
Schistosoma mansoni nck2/grb4 0.0196 0.0321 0.0887
Echinococcus multilocularis serine:threonine protein kinase N2 0.0258 0.0548 0.093
Echinococcus multilocularis CDC7 cell division cycle 7 0.0307 0.0727 0.1241
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.0351 0.0969
Schistosoma mansoni serine/threonine protein kinase 0.0528 0.153 0.4222
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0376 0.0977 0.1382
Onchocerca volvulus 0.0367 0.0945 0.2552
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Echinococcus granulosus calcium activated potassium channel 0.0275 0.0608 0.0854
Entamoeba histolytica protein kinase, putative 0.0207 0.0362 0.1494
Brugia malayi Protein kinase domain containing protein 0.0574 0.1698 0.1687
Loa Loa (eye worm) hypothetical protein 0.0112 0.0018 0.0006
Trichomonas vaginalis CMGC family protein kinase 0.0173 0.0239 0.1322
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Loa Loa (eye worm) hypothetical protein 0.0196 0.0321 0.0309
Trichomonas vaginalis CMGC family protein kinase 0.031 0.0739 0.4089
Loa Loa (eye worm) hypothetical protein 0.0197 0.0327 0.0314
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0246 0.0504 0.0705
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0239 0.048 0.0468
Trichomonas vaginalis CAMK family protein kinase 0.0258 0.0547 0.3029
Leishmania major protein kinase, putative 0.0296 0.0685 0.4316
Echinococcus granulosus tensin 0.0114 0.0024 0.0017
Brugia malayi Protein kinase domain containing protein 0.0172 0.0234 0.0222
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0173 0.0239 0.1504
Entamoeba histolytica protein kinase domain containing protein 0.0318 0.0767 0.3162
Loa Loa (eye worm) AGC/PKA protein kinase 0.0317 0.0764 0.0752
Trichomonas vaginalis CMGC family protein kinase 0.0283 0.0638 0.3533
Giardia lamblia Kinase, NEK 0.0277 0.0618 0.3891
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0114 0.0024 0.002
Echinococcus multilocularis SH2 domain containing protein 7 0.0114 0.0024 0.002
Echinococcus granulosus tyrosine protein kinase Src42A 0.0468 0.1311 0.1862
Trichomonas vaginalis CAMK family protein kinase 0.0544 0.1588 0.8788
Echinococcus multilocularis tensin 0.0114 0.0024 0.002
Trypanosoma brucei aurora B kinase 0.0296 0.0685 0.3793
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0774 0.2426 0.3459
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.028 0.0772
Onchocerca volvulus 0.0211 0.0378 0.0981
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0184 0.028 0.0267
Loa Loa (eye worm) TK/FER protein kinase 0.0211 0.0378 0.0366
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0309 0.0734 0.4063
Echinococcus granulosus expressed conserved protein 0.0114 0.0024 0.0017
Giardia lamblia Kinase, AGC PKA 0.0318 0.0766 0.4824
Echinococcus granulosus casein kinase I delta 0.0222 0.0419 0.0583
Trichomonas vaginalis CMGC family protein kinase 0.0205 0.0357 0.1977
Loa Loa (eye worm) hypothetical protein 0.0112 0.0018 0.0006
Onchocerca volvulus 0.0127 0.0073 0.0135
Schistosoma mansoni protein kinase C mu 0.0439 0.1207 0.333
Brugia malayi hypothetical protein 0.0448 0.124 0.1229
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0693 0.2131 0.2121
Loa Loa (eye worm) TK/FAK protein kinase 0.1116 0.3667 0.3659
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0197 0.0327 0.045
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0869 0.2771 0.4793
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0114 0.0024 0.0012
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0624 0.1878 0.3241
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0114 0.0024 0.002
Loa Loa (eye worm) AUR protein kinase 0.0296 0.0685 0.0674
Echinococcus granulosus tyrosine kinase 0.0386 0.1014 0.1436
Plasmodium falciparum protein serine/threonine kinase-1 0.031 0.0739 0.892
Plasmodium vivax glycogen synthase kinase 3, putative 0.0318 0.0767 0.9263
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0586 0.1742 0.1731
Echinococcus multilocularis protein tyrosine kinase 0.1104 0.3624 0.6275
Echinococcus granulosus casein kinase ii subunit alpha 0.0205 0.0357 0.0494
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0283 0.0638 0.402
Schistosoma mansoni hypothetical protein 0.0203 0.0347 0.0957
Schistosoma mansoni tensin 0.0114 0.0024 0.0067
Trypanosoma brucei protein kinase, putative 0.0318 0.0767 0.4247
Echinococcus multilocularis dual specificity 0.0283 0.0638 0.1087
Brugia malayi protein kinase C II. 0.0426 0.1159 0.1148
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.1199 0.3972 0.3964
Echinococcus multilocularis aurora kinase A 0.0296 0.0685 0.1169
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Echinococcus multilocularis raf serine:threonine protein kinase 0.0181 0.0266 0.0441
Schistosoma mansoni tyrosine kinase 0.0629 0.1899 0.524
Echinococcus multilocularis SH2 motif 0.0114 0.0024 0.002
Entamoeba histolytica PH domain containing protein kinase, putative 0.0336 0.083 0.3423
Trichomonas vaginalis CMGC family protein kinase 0.0283 0.0638 0.3533
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0207 0.0362 0.4376
Schistosoma mansoni serine/threonine protein kinase 0.0283 0.0638 0.1761
Trichomonas vaginalis CAMK family protein kinase 0.0544 0.1588 0.8788
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0815 0.2572 0.3669
Entamoeba histolytica hypothetical protein 0.0249 0.0517 0.2132
Loa Loa (eye worm) hypothetical protein 0.0114 0.0024 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.0362 0.1
Trichomonas vaginalis CMGC family protein kinase 0.0173 0.0239 0.1322
Onchocerca volvulus 0.0307 0.0727 0.1947
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0335 0.0828 0.2285
Schistosoma mansoni serine/threonine protein kinase 0.0274 0.0606 0.1674
Echinococcus multilocularis insulin receptor 0.085 0.2702 0.4673
Echinococcus granulosus tyrosine protein kinase shark 0.0636 0.1922 0.2737
Echinococcus granulosus defective proboscis extension response 0.0166 0.0213 0.0288
Brugia malayi Serine/threonine-protein kinase SULU 0.0448 0.124 0.1229
Leishmania major casein kinase, putative 0.0222 0.0419 0.2639
Giardia lamblia Kinase, NEK 0.0277 0.0618 0.3891
Plasmodium falciparum calcium-dependent protein kinase 1 0.0207 0.0362 0.4376
Schistosoma mansoni serine/threonine protein kinase 0.0774 0.2426 0.6694
Trichomonas vaginalis CAMK family protein kinase 0.0438 0.1202 0.6655
Trichomonas vaginalis CMGC family protein kinase 0.0205 0.0357 0.1977
Echinococcus granulosus activin receptor type 0.0169 0.0226 0.0305
Brugia malayi Furin-like cysteine rich region family protein 0.1071 0.3504 0.3496
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0207 0.0362 0.2081
Schistosoma mansoni serine/threonine protein kinase 0.0544 0.1588 0.4381
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0175 0.0245 0.1546
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0211 0.0378 0.1559
Trichomonas vaginalis CMGC family protein kinase 0.0318 0.0767 0.4247
Echinococcus multilocularis signal transduction protein lnk realted 0.0114 0.0024 0.002
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0146 0.0142 0.0129
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0184 0.028 0.1548
Schistosoma mansoni kinase 0.058 0.1721 0.4749
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0468 0.1311 0.2257
Schistosoma mansoni protein kinase 0.0177 0.0255 0.0704
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0177 0.0255 0.0422
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0173 0.0239 0.1504
Trypanosoma brucei casein kinase I, isoform 2 0.0222 0.0419 0.2319
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0169 0.0226 0.1295
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0115 0.0028 0.0016
Entamoeba histolytica protein kinase, putative 0.0318 0.0767 0.3162
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0989 0.3208 0.5552
Echinococcus multilocularis protein kinase c iota type 0.0588 0.1749 0.3018
Giardia lamblia Kinase, CMGC MAPK 0.0173 0.0239 0.1504
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0468 0.1311 0.2257
Loa Loa (eye worm) hypothetical protein 0.0178 0.0256 0.0243
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0823 0.2604 0.4503
Trichomonas vaginalis AGC family protein kinase 0.034 0.0848 0.4692
Trichomonas vaginalis CMGC family protein kinase 0.0173 0.0239 0.1322
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Schistosoma mansoni vav2 0.0215 0.0391 0.108
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0317 0.0764 0.1305
Echinococcus granulosus titin 0.0146 0.0142 0.0185
Plasmodium vivax protein kinase, putative 0.0127 0.0073 0.0883
Schistosoma mansoni protein kinase 0.0322 0.0781 0.2155
Schistosoma mansoni tyrosine kinase 0.0293 0.0675 0.1864
Schistosoma mansoni ephrin receptor 0.0128 0.0077 0.0213
Brugia malayi intracellular kinase 0.0318 0.0767 0.0755
Brugia malayi Protein kinase domain containing protein 0.0333 0.082 0.0808
Echinococcus granulosus tyrosine protein kinase Fyn 0.0468 0.1311 0.1862
Schistosoma mansoni serine/threonine protein kinase 0.0598 0.1785 0.4926
Echinococcus multilocularis SHC transforming protein 3 0.0114 0.0024 0.002
Echinococcus granulosus protein kinase 0.044 0.1211 0.1718
Entamoeba histolytica protein kinase, putative 0.0134 0.0098 0.0406
Brugia malayi Protein kinase domain containing protein 0.0211 0.0378 0.0366
Loa Loa (eye worm) CMGC/CLK protein kinase 0.031 0.0739 0.0727
Loa Loa (eye worm) TK/EGFR protein kinase 0.1071 0.3504 0.3496
Loa Loa (eye worm) AGC/AKT protein kinase 0.0604 0.1806 0.1796
Echinococcus granulosus fibroblast growth factor receptor 4 0.0492 0.1398 0.1985
Schistosoma mansoni serine/threonine protein kinase 0.0955 0.3082 0.8505
Trypanosoma cruzi casein kinase, putative 0.0222 0.0419 0.2639
Trichomonas vaginalis AGC family protein kinase 0.0381 0.0995 0.551
Echinococcus multilocularis tensin 0.0114 0.0024 0.002
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1265 0.4212 0.4204
Giardia lamblia Kinase, NEK 0.0277 0.0618 0.3891
Schistosoma mansoni serine/threonine protein kinase 0.0275 0.0608 0.1679
Giardia lamblia Kinase, CAMK CAMKL 0.0184 0.028 0.1762
Echinococcus multilocularis casein kinase I delta 0.0222 0.0419 0.0706
Loa Loa (eye worm) TK/FER protein kinase 0.0211 0.0378 0.0366
Schistosoma mansoni serine/threonine protein kinase 0.0317 0.0764 0.2108
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0468 0.1311 0.2257
Giardia lamblia Kinase, CK1 Casein kinase 0.0222 0.0419 0.2639
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0177 0.0255 0.0348
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Plasmodium falciparum protein kinase 5 0.0335 0.0828 1
Entamoeba histolytica casein kinase, putative 0.0205 0.0357 0.1472
Schistosoma mansoni tyrosine kinase 0.0522 0.1508 0.4161
Echinococcus multilocularis SH2 motif 0.0114 0.0024 0.002
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0317 0.0764 0.1305
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0173 0.0239 0.1504
Schistosoma mansoni protein kinase 0.0717 0.2216 0.6116
Loa Loa (eye worm) hypothetical protein 0.0202 0.0346 0.0333
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0172 0.0234 0.1475
Schistosoma mansoni nephrin 0.024 0.0483 0.1334
Trichomonas vaginalis CAMK family protein kinase 0.0233 0.0458 0.2538
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0335 0.0828 0.5216
Trypanosoma cruzi cdc2-related kinase 1 0.0335 0.0828 0.5216
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Echinococcus granulosus casein kinase I delta 0.0222 0.0419 0.0583
Loa Loa (eye worm) hypothetical protein 0.0717 0.2218 0.2208
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0492 0.1398 0.1985
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0815 0.2572 0.4447
Trichomonas vaginalis AGC family protein kinase 0.0168 0.0222 0.1231
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0147 0.0145 0.019
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0196 0.0321 0.0309
Trichomonas vaginalis AGC family protein kinase 0.0604 0.1806 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0207 0.0362 0.0608
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0333 0.082 0.1157
Trichomonas vaginalis CAMK family protein kinase 0.0207 0.0362 0.2006
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0276 0.0615 0.0864
Giardia lamblia Kinase, AGC PKA 0.0317 0.0764 0.4811
Trichomonas vaginalis AGC family protein kinase 0.0296 0.0685 0.3793
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0317 0.0764 0.1305
Loa Loa (eye worm) hypothetical protein 0.0477 0.1344 0.1333
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0296 0.0685 0.2825
Echinococcus multilocularis serine:threonine protein kinase 0.0233 0.0458 0.0775
Plasmodium falciparum casein kinase 2, alpha subunit 0.0205 0.0357 0.4313
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Loa Loa (eye worm) hypothetical protein 0.0359 0.0916 0.0905
Echinococcus multilocularis PAK box P21 Rho binding 0.0134 0.0098 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0544 0.1588 0.8788
Trypanosoma brucei protein kinase, putative 0.0169 0.0226 0.1249
Brugia malayi SH2 domain containing protein 0.0114 0.0024 0.0012
Loa Loa (eye worm) hypothetical protein 0.0114 0.0024 0.0012
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.031 0.0739 0.4653
Trichomonas vaginalis CAMK family protein kinase 0.0544 0.1588 0.8788
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.039 0.1027 0.1016
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0323 0.0784 0.4938
Echinococcus multilocularis mitogen activated protein kinase 11 0.0323 0.0784 0.134
Schistosoma mansoni tyrosine kinase 0.085 0.2702 0.7456
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0029 0.0079
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Loa Loa (eye worm) AGC/PKG protein kinase 0.0274 0.0606 0.0595
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.1051 0.3433 0.4903
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.013 0.0084 0.0465
Brugia malayi SH2 domain containing protein 0.0114 0.0024 0.0012
Echinococcus multilocularis 0.0238 0.0477 0.0807
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0205 0.0357 0.4313
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0207 0.0362 0.0608
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0323 0.0784 0.0772
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0233 0.0458 0.0446
Brugia malayi Immunoglobulin I-set domain containing protein 0.1265 0.4212 0.4204
Echinococcus granulosus signal transduction protein lnk realted 0.0114 0.0024 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0318 0.0767 0.1082
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0207 0.0362 0.035
Giardia lamblia Kinase, CMGC DYRK 0.0283 0.0638 0.402
Trypanosoma cruzi cdc2-related kinase 3 0.0335 0.0828 0.5216
Brugia malayi SH2 domain containing protein 0.0114 0.0024 0.0012
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0173 0.0239 0.1322
Schistosoma mansoni serine/threonine protein kinase 0.0241 0.0488 0.1347
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0173 0.0239 0.1504
Schistosoma mansoni serine/threonine protein kinase 0.0376 0.0977 0.2695
Trypanosoma cruzi aurora B kinase, putative 0.0296 0.0685 0.4316
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.034 0.0848 0.1451
Echinococcus granulosus serine:threonine kinase SAD 1 0.0184 0.028 0.0383
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0276 0.0615 0.3877
Echinococcus granulosus ephrin type A receptor 4 A 0.0225 0.0427 0.0594
Trypanosoma cruzi Protein kinase B 0.0336 0.083 0.5231
Brugia malayi hypothetical protein 0.0197 0.0327 0.0314
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0028 0.0078
Echinococcus granulosus casein kinase I alpha 0.0222 0.0419 0.0583
Loa Loa (eye worm) hypothetical protein 0.0197 0.0327 0.0314
Loa Loa (eye worm) hypothetical protein 0.0918 0.2946 0.2937
Brugia malayi SRC-1 0.0468 0.1311 0.13
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0245 0.0502 0.0851
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0207 0.0362 0.2006
Loa Loa (eye worm) TK/ABL protein kinase 0.0624 0.1878 0.1868
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0196 0.0321 0.0309
Echinococcus granulosus protein kinase c iota type 0.0588 0.1749 0.249
Brugia malayi serine/threonine kinase 12 0.0296 0.0685 0.0674
Loa Loa (eye worm) hypothetical protein 0.0284 0.0643 0.0631
Brugia malayi hypothetical protein 0.0114 0.0024 0.0012
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0151 0.0157 0.0992
Schistosoma mansoni vam6/vps39 related 0.0276 0.0615 0.1699
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0448 0.124 0.1229
Loa Loa (eye worm) CAMK protein kinase 0.0146 0.0142 0.0129
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0134 0.0098 0.0086
Echinococcus granulosus casein kinase i 0.0222 0.0419 0.0583
Echinococcus granulosus SH2 domain containing protein 7 0.0114 0.0024 0.0017
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0322 0.0781 0.1335
Echinococcus multilocularis mitogen activated protein kinase 0.0173 0.0239 0.0393
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0249 0.0517 0.3258
Schistosoma mansoni shc transforming protein 0.0114 0.0024 0.0067
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.031 0.0739 0.4653
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0283 0.0638 0.3533
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Echinococcus granulosus mitogen activated protein kinase 0.0173 0.0239 0.0324
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0386 0.1014 0.174
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0274 0.0606 0.3482
Echinococcus multilocularis 0.044 0.1211 0.2082
Schistosoma mansoni serine/threonine protein kinase 0.0222 0.0419 0.1156
Trichomonas vaginalis CAMK family protein kinase 0.0544 0.1588 0.8788
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Trichomonas vaginalis STE family protein kinase 0.0177 0.0255 0.1413
Entamoeba histolytica protein kinase, putative 0.0296 0.0685 0.2825
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0222 0.0419 0.2639
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0183 0.0274 0.0262
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0114 0.0024 0.0017
Trichomonas vaginalis CMGC family protein kinase 0.0335 0.0828 0.4584
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.2029 0.6988 1
Schistosoma mansoni serine/threonine protein kinase 0.034 0.0848 0.2339
Loa Loa (eye worm) hypothetical protein 0.0284 0.0643 0.0631
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0249 0.0517 0.3258
Schistosoma mansoni serine/threonine protein kinase 0.0513 0.1477 0.4076
Echinococcus granulosus casein kinase I alpha 0.0222 0.0419 0.0583
Trichomonas vaginalis AGC family protein kinase 0.0317 0.0764 0.4228
Loa Loa (eye worm) protein kinase domain-containing protein 0.043 0.1175 0.1164
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0276 0.0615 0.1699
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0335 0.0828 0.0817
Echinococcus granulosus suppressor of cytokine signaling 7 0.0114 0.0024 0.0017
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0296 0.0685 0.2825
Leishmania major protein kinase, putative 0.0169 0.0226 0.1421
Entamoeba histolytica serine/threonine protein kinase, putative 0.0184 0.028 0.1153
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.0113 0.0019 0.0108
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0186 0.0286 0.1178
Trichomonas vaginalis CK1 family protein kinase 0.0222 0.0419 0.2319
Echinococcus granulosus epidermal growth factor receptor 0.1071 0.3504 0.5005
Echinococcus granulosus cGMP dependent protein kinase 0.0274 0.0606 0.0851
Entamoeba histolytica protein kinase, putative 0.0586 0.1742 0.718
Toxoplasma gondii casein kinase I 0.0222 0.0419 0.2405
Plasmodium falciparum serine/threonine protein kinase KIN 0.0184 0.028 0.3378
Echinococcus granulosus titin 0.0146 0.0142 0.0185
Echinococcus multilocularis tyrosine protein kinase Abl 0.0451 0.1249 0.2148
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.031 0.0739 0.4089
Schistosoma mansoni cell adhesion molecule 0.0111 0.0013 0.0035
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0376 0.0977 0.0965
Onchocerca volvulus 0.0156 0.0176 0.042
Entamoeba histolytica protein kinase, putative 0.0604 0.1806 0.7446
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Trichomonas vaginalis AGC family protein kinase 0.0604 0.1806 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0114 0.0024 0.002
Echinococcus multilocularis activin receptor type 0.0169 0.0226 0.037
Plasmodium vivax serine/threonine protein kinase, putative 0.0172 0.0234 0.2828
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0356 0.0904 0.0893
Echinococcus multilocularis epidermal growth factor receptor 0.1071 0.3504 0.6067
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Schistosoma mansoni protein kinase 0.0205 0.0357 0.0986
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0508 0.1456 0.1445
Trichomonas vaginalis CMGC family protein kinase 0.0205 0.0357 0.1977
Echinococcus granulosus SH2 motif 0.0114 0.0024 0.0017
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0114 0.0024 0.0012
Entamoeba histolytica protein kinase domain containing protein 0.0169 0.0226 0.093
Echinococcus multilocularis cyclin dependent kinase 5 0.0335 0.0828 0.1417
Schistosoma mansoni serine/threonine protein kinase 0.0275 0.0608 0.1679
Brugia malayi Protein kinase domain containing protein 0.0383 0.1002 0.0991
Loa Loa (eye worm) hypothetical protein 0.0114 0.0024 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0296 0.0685 0.3793
Schistosoma mansoni serine/threonine protein kinase 0.0406 0.1085 0.2994
Loa Loa (eye worm) TK/FER protein kinase 0.0211 0.0378 0.0366
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0222 0.0419 0.0407
Echinococcus granulosus serine:threonine protein kinase 3 0.0517 0.149 0.2118
Brugia malayi serine/threonine-protein kinase PAK 7 0.0468 0.1311 0.13
Entamoeba histolytica PH domain containing protein kinase, putative 0.0335 0.0828 0.3415
Schistosoma mansoni serine/threonine protein kinase 0.0505 0.1446 0.399
Onchocerca volvulus 0.0211 0.0378 0.0981
Echinococcus multilocularis Glutaredoxin protein 5 0.0246 0.0504 0.0854
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0335 0.0828 0.1169
Schistosoma mansoni serine/threonine-protein kinase 0.0336 0.083 0.2292
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0172 0.0234 0.1296
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0277 0.0618 0.3546
Toxoplasma gondii CMGC kinase, CK2 family 0.0205 0.0357 0.2051
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0173 0.0239 0.0226
Plasmodium vivax calcium-dependent protein kinase, putative 0.0207 0.0362 0.4376
Loa Loa (eye worm) hypothetical protein 0.0263 0.0567 0.0555
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0438 0.1202 0.1191
Brugia malayi Protein kinase domain containing protein 0.1199 0.3972 0.3964
Echinococcus granulosus N chimaerin 0.0197 0.0327 0.045
Echinococcus multilocularis tyrosine protein kinase 0.0574 0.1698 0.2928
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0544 0.1588 0.2258
Brugia malayi Protein kinase domain containing protein 0.079 0.2483 0.2473
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0318 0.0766 0.9247
Schistosoma mansoni atypical protein kinase C 0.06 0.1793 0.4949
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0184 0.028 0.1762
Entamoeba histolytica protein kinase, putative 0.034 0.0848 0.3494
Brugia malayi Fes/CIP4 homology domain containing protein 0.0233 0.0456 0.0444
Echinococcus granulosus nervana 2 0.0246 0.0504 0.0705
Entamoeba histolytica protein kinase 2, putative 0.0318 0.0766 0.3157
Echinococcus granulosus Glutaredoxin protein 5 0.0246 0.0504 0.0705
Schistosoma mansoni cell adhesion molecule 0.0233 0.0459 0.1266
Brugia malayi Protein kinase domain containing protein 0.0335 0.0828 0.0817
Brugia malayi Protein kinase domain containing protein 0.1199 0.3972 0.3964
Echinococcus granulosus cyclin dependent kinase 5 0.0335 0.0828 0.1169
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0207 0.0362 0.0502
Trichomonas vaginalis CAMK family protein kinase 0.0544 0.1588 0.8788
Brugia malayi Protein kinase domain containing protein 0.0307 0.0727 0.0715
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0318 0.0766 0.4824
Brugia malayi Protein kinase domain containing protein 0.085 0.2702 0.2693
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0168 0.0222 0.0365
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0177 0.0255 0.0348
Echinococcus multilocularis casein kinase i 0.0222 0.0419 0.0706
Echinococcus granulosus protein kinase c epsilon type 0.0426 0.1159 0.1644
Loa Loa (eye worm) TK/FER protein kinase 0.0211 0.0378 0.0366
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0318 0.0766 0.1309
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.014 0.0121 0.0155
Echinococcus granulosus nervana 2 0.0246 0.0504 0.0705
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0197 0.0327 0.0546
Trichomonas vaginalis AGC family protein kinase 0.0399 0.106 0.5868
Brugia malayi protein kinase C3,putative 0.032 0.0773 0.0762
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0436 0.1195 0.2055
Echinococcus granulosus serine/threonine protein kinase 0.0336 0.083 0.1172
Loa Loa (eye worm) AUR protein kinase 0.0296 0.0685 0.0674
Loa Loa (eye worm) hypothetical protein 0.0114 0.0024 0.0012
Loa Loa (eye worm) gastrulation defective protein 1 0.0132 0.009 0.0077
Schistosoma mansoni cell adhesion molecule 0.0111 0.0013 0.0035
Schistosoma mansoni suppressor of cytokine signaling 0.0114 0.0024 0.0067
Echinococcus granulosus CDC7 cell division cycle 7 0.0307 0.0727 0.1024
Trichomonas vaginalis CAMK family protein kinase 0.0235 0.0465 0.2577
Plasmodium vivax tyrosine kinase-like protein, putative 0.0167 0.0219 0.2645
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0274 0.0606 0.1032
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0318 0.0767 0.1311
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0333 0.082 0.1403
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Loa Loa (eye worm) casein kinase 0.0358 0.0914 0.0902
Schistosoma mansoni serine/threonine protein kinase 0.0426 0.1159 0.3199
Echinococcus multilocularis cyclin dependent kinase 19 0.0204 0.0351 0.0588
Echinococcus multilocularis mitogen activated protein kinase 11 0.0323 0.0784 0.134
Echinococcus granulosus tyrosine protein kinase HCK 0.0272 0.06 0.0842
Brugia malayi Tyrosine-protein kinase abl-1 0.0255 0.0536 0.0524
Brugia malayi SH2 domain containing protein 0.0114 0.0024 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0211 0.0378 0.0366
Echinococcus granulosus SH2 motif 0.0114 0.0024 0.0017
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0276 0.0615 0.1699
Brugia malayi SH2 domain containing protein 0.0114 0.0024 0.0012
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0207 0.0362 0.0502
Brugia malayi Protein kinase domain containing protein 0.0211 0.0378 0.0366
Brugia malayi Protein kinase domain containing protein 0.0211 0.0378 0.0366
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0386 0.1014 0.1436
Echinococcus multilocularis expressed conserved protein 0.0274 0.0606 0.1032
Echinococcus granulosus cyclin dependent kinase 1 0.0335 0.0828 0.1169
Schistosoma mansoni tyrosine kinase 0.0468 0.1311 0.3619
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0197 0.0327 0.0901
Echinococcus granulosus c-Jun N-terminal kinases 0.0532 0.1544 0.2195
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0168 0.0222 0.021
Trypanosoma brucei cdc2-related kinase 1 0.0335 0.0828 0.4584
Schistosoma mansoni serine/threonine protein kinase 0.0249 0.0517 0.1427
Trypanosoma cruzi casein kinase, putative 0.0222 0.0419 0.2639
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0114 0.0024 0.002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0146 0.0142 0.0129
Trypanosoma cruzi casein kinase, putative 0.0222 0.0419 0.2639
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0196 0.0321 0.0887
Schistosoma mansoni SH2A 0.0114 0.0024 0.0067
Brugia malayi Egg laying defective protein 4 0.0274 0.0606 0.0595
Echinococcus granulosus SH2 domain containing adapter protein F 0.0114 0.0024 0.0017
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0114 0.0024 0.002
Schistosoma mansoni neuroglian 0.0111 0.0013 0.0035
Schistosoma mansoni protein kinase 0.0869 0.2771 0.7646
Loa Loa (eye worm) CAMK/PIM protein kinase 0.1051 0.3433 0.3425
Schistosoma mansoni tyrosine kinase 0.0636 0.1922 0.5304
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0114 0.0024 0.0017
Leishmania major protein kinase, putative 0.031 0.0739 0.4653
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0245 0.0502 0.0702
Echinococcus multilocularis roundabout 2 0.0277 0.0616 0.1048
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0376 0.0977 0.1675
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.0113 0.0019 0.0108
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0332 0.0817 0.0806
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0204 0.0351 0.0339
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0323 0.0784 0.4339
Brugia malayi Casein kinase II, alpha chain 0.0205 0.0357 0.0345
Giardia lamblia Kinase, CMGC CLK 0.031 0.0739 0.4653
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0173 0.0239 0.1504
Echinococcus granulosus NDR protein kinase 0.034 0.0848 0.1197
Trichomonas vaginalis AGC family protein kinase 0.0604 0.1806 1
Brugia malayi Protein kinase domain containing protein 0.0211 0.0378 0.0366
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0293 0.0675 0.1864
Brugia malayi Protein kinase domain containing protein 0.0381 0.0995 0.0984
Brugia malayi Protein kinase domain containing protein 0.0438 0.1202 0.1191
Loa Loa (eye worm) TK/FER protein kinase 0.0211 0.0378 0.0366
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0335 0.0828 0.5216
Trichomonas vaginalis CMGC family protein kinase 0.0307 0.0727 0.4023
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0177 0.0255 0.0422
Trichomonas vaginalis CMGC family protein kinase 0.0283 0.0638 0.3533
Schistosoma mansoni tyrosine kinase 0.0492 0.1398 0.3857
Loa Loa (eye worm) hypothetical protein 0.0207 0.0362 0.035
Brugia malayi cell division control protein 2 homolog 0.0335 0.0828 0.0817
Echinococcus multilocularis SH2 motif 0.0114 0.0024 0.002
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Echinococcus multilocularis serine:threonine protein kinase 3 0.0517 0.149 0.2568
Echinococcus granulosus MAP kinase activated protein kinase 2 0.079 0.2484 0.3542
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0222 0.0419 0.0407
Plasmodium falciparum cGMP-dependent protein kinase 0.0274 0.0606 0.7324
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0028 0.0078
Echinococcus granulosus mitogen activated protein kinase 11 0.0323 0.0784 0.1106
Brugia malayi hypothetical protein 0.0276 0.0615 0.0604
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0274 0.0606 0.1032
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0318 0.0767 0.4404
Echinococcus multilocularis dual specificity 0.0283 0.0638 0.1087
Brugia malayi serine/threonine-protein kinase plk-2 0.0544 0.1588 0.1577
Entamoeba histolytica protein kinase domain containing protein 0.0318 0.0767 0.3162
Echinococcus granulosus neuroglian 0.0209 0.037 0.0513
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0448 0.124 0.176
Trichomonas vaginalis AGC family protein kinase 0.0168 0.0222 0.1231
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0335 0.0828 0.4755
Brugia malayi Serine/threonine-protein kinase Pim-3 0.1051 0.3433 0.3425
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0207 0.0362 0.2081
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.028 0.1548
Loa Loa (eye worm) hypothetical protein 0.0245 0.0503 0.0491
Loa Loa (eye worm) hypothetical protein 0.0114 0.0024 0.0012
Onchocerca volvulus 0.0385 0.101 0.2731
Echinococcus multilocularis mitogen activated protein kinase 3 0.0173 0.0239 0.0393
Brugia malayi Protein kinase domain containing protein 0.1116 0.3667 0.3659
Onchocerca volvulus 0.0276 0.0615 0.1638
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0335 0.0828 0.0817
Entamoeba histolytica cell division protein kinase 2, putative 0.0335 0.0828 0.3414
Loa Loa (eye worm) hypothetical protein 0.0114 0.0024 0.0012
Loa Loa (eye worm) hypothetical protein 0.0317 0.0764 0.0752
Loa Loa (eye worm) hypothetical protein 0.0114 0.0024 0.0012
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0235 0.0465 0.0649
Schistosoma mansoni serine/threonine protein kinase 0.0333 0.082 0.2262
Schistosoma mansoni serine/threonine protein kinase 0.0317 0.0764 0.2108
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0173 0.0239 0.1371
Brugia malayi Cam kinase protein 1 0.0207 0.0362 0.035
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0114 0.0024 0.0067
Echinococcus granulosus rho-associated protein kinase 1 0.0967 0.3127 0.4465
Mycobacterium ulcerans hypothetical protein 0.0202 0.0345 0.5
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0246 0.0504 0.0854
Brugia malayi Temporarily assigned gene name protein 59 0.0257 0.0543 0.0531
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0114 0.0024 0.0017
Loa Loa (eye worm) hypothetical protein 0.0414 0.1115 0.1104
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0468 0.1311 0.2257
Echinococcus multilocularis hypothetical protein 0.0203 0.0347 0.0581
Plasmodium falciparum calcium-dependent protein kinase 4 0.0207 0.0362 0.4376
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0317 0.0764 0.4811
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0207 0.0362 0.035
Entamoeba histolytica casein kinase, putative 0.0222 0.0419 0.1727
Trichomonas vaginalis AGC family protein kinase 0.0113 0.0019 0.0108
Brugia malayi serine/threonine-protein kinase 6 0.0296 0.0685 0.0674
Trichomonas vaginalis AGC family protein kinase 0.013 0.0084 0.0465
Schistosoma mansoni protein kinase 0.0869 0.2771 0.7646
Brugia malayi Protein kinase domain containing protein 0.0204 0.0351 0.0339
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0376 0.0977 0.0965
Loa Loa (eye worm) TK/ROR protein kinase 0.014 0.0121 0.0109
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0317 0.0764 0.4228
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.034 0.0848 0.1197
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0406 0.1085 0.1537
Brugia malayi Fibronectin type III domain containing protein 0.0197 0.0327 0.0314
Loa Loa (eye worm) hypothetical protein 0.0276 0.0615 0.0604
Schistosoma mansoni tensin-related 0.0114 0.0024 0.0067
Brugia malayi Protein kinase domain 0.0177 0.0255 0.0243
Brugia malayi Protein kinase domain containing protein 0.0233 0.0458 0.0446
Echinococcus granulosus tyrosine kinase 0.0211 0.0378 0.0524
Brugia malayi hypothetical protein 0.0112 0.0018 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0604 0.1806 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.0213 0.0201

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.