Detailed information for compound 1349034

Basic information

Technical information
  • TDR Targets ID: 1349034
  • Name: N-(1,3-benzodioxol-5-yl)-2-[[5-[(1-methylpyrr ol-2-yl)methyl]-4-(2-phenylethyl)-1,2,4-triaz ol-3-yl]sulfanyl]acetamide
  • MW: 475.563 | Formula: C25H25N5O3S
  • H donors: 1 H acceptors: 3 LogP: 3.61 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc2c(c1)OCO2)CSc1nnc(n1CCc1ccccc1)Cc1cccn1C
  • InChi: 1S/C25H25N5O3S/c1-29-12-5-8-20(29)15-23-27-28-25(30(23)13-11-18-6-3-2-4-7-18)34-16-24(31)26-19-9-10-21-22(14-19)33-17-32-21/h2-10,12,14H,11,13,15-17H2,1H3,(H,26,31)
  • InChiKey: AJRSWNSYAWHJLB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(1,3-benzodioxol-5-yl)-2-[[5-[(1-methyl-2-pyrrolyl)methyl]-4-(2-phenylethyl)-1,2,4-triazol-3-yl]thio]acetamide
  • N-(1,3-benzodioxol-5-yl)-2-[[5-[(1-methylpyrrol-2-yl)methyl]-4-(2-phenylethyl)-1,2,4-triazol-3-yl]thio]acetamide
  • N-(1,3-benzodioxol-5-yl)-2-[[5-[(1-methylpyrrol-2-yl)methyl]-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanamide
  • MLS000118673
  • SMR000095613
  • MLS000878563

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis casein kinase I delta 0.011 0.0614 0.0743
Schistosoma mansoni serine/threonine kinase 0.0219 0.1734 0.2991
Loa Loa (eye worm) hypothetical protein 0.0073 0.0239 0.0259
Trichomonas vaginalis AGC family protein kinase 0.0304 0.2598 1
Echinococcus granulosus serine threonine protein kinase nrc 0.0158 0.111 0.111
Leishmania major protein kinase A catalytic subunit 0.0114 0.0659 0.2838
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0399 0.3566 0.3864
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Entamoeba histolytica protein kinase, putative 0.0084 0.035 0.0982
Trypanosoma brucei protein kinase, putative 0.013 0.0821 0.312
Brugia malayi SH2 domain containing protein 0.01 0.0517 0.056
Schistosoma mansoni protein kinase 0.0268 0.2229 0.3845
Echinococcus granulosus protein tyrosine kinase 0.0558 0.5189 0.5189
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0078 0.0293 0.1224
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.1673 0.2885
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0094 0.0454 0.1934
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0357 0.3136 0.3136
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0526 0.1977
Giardia lamblia Kinase, CMGC CDK 0.012 0.0719 0.3101
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0161 0.1136 0.4339
Trichomonas vaginalis AGC family protein kinase 0.0304 0.2598 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0055 0.0056 0.0067
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0087 0.038 0.038
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0088 0.0392 0.1107
Loa Loa (eye worm) hypothetical protein 0.0088 0.0398 0.0432
Brugia malayi Protein kinase domain containing protein 0.0607 0.5694 0.617
Echinococcus multilocularis nervana 2 0.0125 0.0773 0.0936
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0147 0.0995 0.2874
Plasmodium vivax protein kinase Crk2 0.012 0.0719 0.6429
Brugia malayi Protein kinase domain containing protein 0.0203 0.1566 0.1697
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0517 0.056
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0113 0.065 0.1121
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0055 0.0056 0.006
Schistosoma mansoni tyrosine kinase 0.0372 0.3296 0.5684
Schistosoma mansoni tyrosine kinase 0.0261 0.2164 0.3732
Echinococcus multilocularis 0.0122 0.0742 0.0899
Echinococcus granulosus tyrosine protein kinase ABL1 0.01 0.0517 0.0517
Trypanosoma cruzi cdc2-related kinase 3 0.012 0.0719 0.3101
Loa Loa (eye worm) TK protein kinase 0.0189 0.1427 0.1546
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0136 0.0882 0.3482
Echinococcus multilocularis Glutaredoxin protein 5 0.0125 0.0773 0.0936
Schistosoma mansoni atypical protein kinase C 0.0302 0.258 0.4449
Echinococcus multilocularis tensin 0.0055 0.0056 0.0067
Schistosoma mansoni hypothetical protein 0.0055 0.0056 0.0096
Echinococcus granulosus hypothetical protein 0.0122 0.0742 0.0742
Giardia lamblia Kinase, CMGC MAPK 0.0094 0.0454 0.1934
Brugia malayi Fibronectin type III domain containing protein 0.0088 0.0398 0.0432
Schistosoma mansoni tyrosine kinase 0.0558 0.5189 0.895
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0097 0.0488 0.0842
Trichomonas vaginalis AGC family protein kinase 0.0147 0.0995 0.3793
Entamoeba histolytica serine/threonine protein kinase, putative 0.0273 0.2285 0.6659
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0055 0.0056 0.0179
Echinococcus granulosus casein kinase I gamma 0.0216 0.1695 0.1695
Echinococcus granulosus myotubularin protein 13 0.0051 0.002 0.002
Echinococcus multilocularis N chimaerin 0.0097 0.0488 0.0591
Mycobacterium ulcerans hypothetical protein 0.0103 0.0546 0.5
Echinococcus granulosus SH2 domain containing adapter protein F 0.0055 0.0056 0.0056
Brugia malayi Tyrosine-protein kinase abl-1 0.0131 0.0835 0.0905
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0102 0.0533 0.0646
Loa Loa (eye worm) hypothetical protein 0.0145 0.0971 0.1053
Giardia lamblia Kinase, CMGC CK2 0.0101 0.0526 0.225
Brugia malayi Protein kinase domain 0.0087 0.038 0.0412
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0357 0.3136 0.3398
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.006
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0407 0.3654 0.4422
Loa Loa (eye worm) CDC7 protein kinase 0.0091 0.0419 0.0454
Loa Loa (eye worm) hypothetical protein 0.031 0.2662 0.2884
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0607 0.5694 0.617
Brugia malayi Protein kinase domain containing protein 0.0219 0.1734 0.1879
Echinococcus multilocularis signal transduction protein lnk realted 0.0055 0.0056 0.0067
Giardia lamblia Kinase, NEK 0.0137 0.0898 0.3891
Brugia malayi Protein kinase domain containing protein 0.012 0.0719 0.0779
Entamoeba histolytica cell division protein kinase 2, putative 0.012 0.0719 0.2065
Echinococcus granulosus tyrosine protein kinase Src42A 0.0146 0.0986 0.0986
Trichomonas vaginalis STE family protein kinase 0.0085 0.0366 0.1358
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0333 0.0575
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.006
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.013 0.0821 0.3236
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0267 0.2223 0.2691
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Schistosoma mansoni tyrosine kinase 0.022 0.1745 0.3009
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0055 0.0056 0.0067
Echinococcus multilocularis CDC7 cell division cycle 7 0.0091 0.0419 0.0507
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0415 0.0716
Entamoeba histolytica protein kinase, putative 0.0134 0.0866 0.2495
Echinococcus granulosus expressed protein 0.0084 0.035 0.035
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0015 0.0026
Loa Loa (eye worm) hypothetical protein 0.01 0.0517 0.056
Trichomonas vaginalis CAMK family protein kinase 0.0273 0.2285 0.8788
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0109 0.0119
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.017 0.1227 0.1227
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0114 0.0659 0.2494
Brugia malayi Protein kinase domain containing protein 0.017 0.1227 0.133
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0094 0.0454 0.1934
Schistosoma mansoni tyrosine kinase 0.0246 0.2006 0.346
Plasmodium vivax glycogen synthase kinase 3, putative 0.013 0.0821 0.736
Trichomonas vaginalis AGC family protein kinase 0.0114 0.0659 0.2494
Brugia malayi casein kinase 1, delta 0.011 0.0614 0.0666
Loa Loa (eye worm) hypothetical protein 0.0113 0.065 0.0704
Echinococcus granulosus dual specificity 0.0123 0.0755 0.0755
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0102 0.0533 0.2081
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0399 0.3566 0.3566
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0114 0.0659 0.2838
Leishmania major protein kinase, putative 0.0085 0.0366 0.1546
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.009 0.0415 0.1762
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.013 0.0821 0.355
Schistosoma mansoni tyrosine kinase 0.0361 0.3184 0.5492
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.0054 0.0043 0.0108
Toxoplasma gondii AGC kinase 0.0295 0.2506 1
Brugia malayi SH2 domain containing protein 0.0055 0.0056 0.006
Brugia malayi SH2 domain containing protein 0.0407 0.3654 0.3959
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0086 0.0374 0.0405
Schistosoma mansoni serine/threonine protein kinase 0.0123 0.0755 0.1302
Trypanosoma cruzi cdc2-related kinase 1 0.012 0.0719 0.3101
Echinococcus multilocularis tyrosine protein kinase Abl 0.0131 0.0835 0.1011
Schistosoma mansoni ephrin receptor 0.0061 0.0118 0.0204
Loa Loa (eye worm) AGC/PKA protein kinase 0.0114 0.0659 0.0714
Brugia malayi serine/threonine protein kinase 6 0.0147 0.0995 0.1078
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.009 0.0415 0.1762
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0246 0.2006 0.2428
Echinococcus granulosus calcium dependent protein kinase 0.0069 0.0197 0.0197
Trypanosoma cruzi casein kinase II, putative 0.0101 0.0526 0.225
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0357 0.3136 0.3398
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0065 0.0161 0.0175
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0102 0.0533 0.2081
Echinococcus multilocularis activin receptor type 0.0078 0.0293 0.0355
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.0533 0.2006
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0175 0.0212
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0439 0.3977 0.4814
Trichomonas vaginalis CMGC family protein kinase 0.012 0.0719 0.2725
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0517 0.056
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.006
Leishmania major protein kinase, putative 0.0147 0.0995 0.4316
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0205 0.1586 0.1919
Loa Loa (eye worm) TK protein kinase 0.0352 0.3093 0.3351
Echinococcus multilocularis dual specificity 0.014 0.0928 0.1123
Echinococcus multilocularis tyrosine protein kinase 0.0288 0.2435 0.2947
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0114 0.0659 0.2494
Echinococcus multilocularis serine:threonine protein kinase 38 0.017 0.1227 0.1485
Plasmodium falciparum serine/threonine protein kinase 0.0084 0.035 0.3058
Trypanosoma cruzi casein kinase, putative 0.011 0.0614 0.2639
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0056 0.0096
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0085 0.0366 0.1546
Schistosoma mansoni cell adhesion molecule 0.0103 0.0548 0.0945
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0166 0.1187 0.1187
Brugia malayi Protein kinase domain containing protein 0.0091 0.0419 0.0454
Brugia malayi SH2 domain containing protein 0.0055 0.0056 0.006
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.011 0.0614 0.0666
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.1187 0.2048
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.012 0.0719 0.0779
Echinococcus multilocularis 0.0176 0.129 0.1562
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.013 0.0821 0.1416
Trichomonas vaginalis CK1 family protein kinase 0.011 0.0614 0.2319
Brugia malayi Furin-like cysteine rich region family protein 0.0617 0.5798 0.6282
Echinococcus multilocularis tyrosine kinase 0.01 0.0517 0.0626
Brugia malayi serine/threonine-protein kinase 6 0.0147 0.0995 0.1078
Brugia malayi RhoGAP domain containing protein 0.0097 0.0488 0.0529
Schistosoma mansoni tensin 0.0055 0.0056 0.0096
Schistosoma mansoni ephrin receptor 0.011 0.0618 0.1066
Echinococcus multilocularis mitogen activated protein kinase 11 0.0161 0.1136 0.1375
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.012 0.0719 0.3101
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0517 0.056
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0055 0.0056 0.0157
Loa Loa (eye worm) hypothetical protein 0.0088 0.0398 0.0432
Loa Loa (eye worm) AUR protein kinase 0.0147 0.0995 0.1078
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0055 0.0056 0.006
Brugia malayi STAT protein, DNA binding domain containing protein 0.0055 0.0056 0.006
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0081 0.0323 0.039
Brugia malayi STE20-like kinase MST 0.026 0.2146 0.2325
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Loa Loa (eye worm) hypothetical protein 0.0467 0.4265 0.4621
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Brugia malayi tRNA modification GTPase TrmE family protein 0.0055 0.0056 0.006
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0114 0.0659 0.0714
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0401 0.3593 0.4349
Schistosoma mansoni protein kinase 0.0147 0.0995 0.1716
Echinococcus granulosus serine:threonine protein kinase 3 0.026 0.2146 0.2146
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0189 0.1427 0.1427
Trypanosoma brucei aurora B kinase 0.0147 0.0995 0.3793
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0885 0.1526
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0137 0.0898 0.3546
Echinococcus granulosus Glutaredoxin protein 5 0.0125 0.0773 0.0773
Plasmodium falciparum cGMP-dependent protein kinase 0.0136 0.0882 0.792
Brugia malayi Protein kinase c protein 2 0.0117 0.0687 0.0744
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0517 0.056
Trichomonas vaginalis CMGC family protein kinase 0.0155 0.1079 0.412
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0415 0.0716
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0295 0.2506 0.2715
Echinococcus multilocularis tyrosine protein kinase ABL1 0.01 0.0517 0.0626
Schistosoma mansoni tyrosine kinase 0.0077 0.0281 0.0484
Echinococcus granulosus titin 0.0068 0.0187 0.0187
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.017 0.1227 0.1227
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0063 0.0135 0.0465
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Onchocerca volvulus 0.01 0.0517 0.1389
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.011 0.0614 0.0666
Loa Loa (eye worm) CMGC/GSK protein kinase 0.013 0.0821 0.089
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0225 0.1788 0.2164
Plasmodium vivax tyrosine kinase-like protein, putative 0.0082 0.0328 0.286
Trypanosoma cruzi casein kinase, putative 0.011 0.0614 0.2639
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0084 0.035 0.1296
Schistosoma mansoni tyrosine kinase 0.0316 0.2725 0.4699
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0454 0.17
Brugia malayi Egg laying defective protein 4 0.0136 0.0882 0.0956
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.006
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0246 0.2006 0.2428
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0161 0.1136 0.4938
Echinococcus granulosus N chimaerin 0.0097 0.0488 0.0488
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.1788 0.3084
Schistosoma mansoni protein kinase 0.0371 0.3283 0.5662
Entamoeba histolytica protein kinase, putative 0.0103 0.0546 0.1558
Echinococcus granulosus tyrosine protein kinase shark 0.0316 0.2725 0.2725
Echinococcus multilocularis mitogen activated protein kinase 11 0.0161 0.1136 0.1375
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.009 0.0415 0.045
Entamoeba histolytica casein kinase, putative 0.011 0.0614 0.1757
Echinococcus granulosus mitogen activated protein kinase 11 0.0161 0.1136 0.1136
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.014 0.0928 0.1005
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0102 0.0533 0.4733
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0102 0.0533 0.0646
Loa Loa (eye worm) hypothetical protein 0.009 0.0415 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0043 0.0109
Giardia lamblia Kinase, CMGC CDK 0.012 0.0719 0.3101
Schistosoma mansoni tyrosine kinase 0.0617 0.5798 1
Echinococcus multilocularis serine:threonine protein kinase 0.0115 0.0671 0.0812
Schistosoma mansoni protein kinase 0.0439 0.3977 0.6859
Echinococcus multilocularis casein kinase I alpha 0.011 0.0614 0.0743
Onchocerca volvulus 0.0187 0.1404 0.4058
Brugia malayi Serine/threonine-protein kinase SULU 0.0225 0.1788 0.1937
Schistosoma mansoni kinase 0.0292 0.2476 0.427
Echinococcus granulosus STE20 serine:threonine protein kinase 0.05 0.4602 0.4602
Loa Loa (eye worm) TK protein kinase 0.0134 0.0866 0.0938
Loa Loa (eye worm) hypothetical protein 0.0087 0.0386 0.0418
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Echinococcus multilocularis tyrosine protein kinase Src64B 0.022 0.1745 0.2112
Plasmodium falciparum calcium-dependent protein kinase 5 0.0102 0.0533 0.4733
Schistosoma mansoni protein kinase 0.0065 0.0156 0.0269
Trichomonas vaginalis STE family protein kinase 0.0137 0.0898 0.3419
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0533 0.092
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Echinococcus granulosus serine/threonine protein kinase 0.0167 0.1203 0.1203
Giardia lamblia Kinase, CMGC SRPK 0.0084 0.035 0.1475
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0087 0.038 0.038
Entamoeba histolytica hypothetical protein 0.0385 0.3424 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0102 0.0533 0.0533
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0218 0.1724 0.1724
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0055 0.0056 0.0067
Loa Loa (eye worm) TK protein kinase 0.0288 0.2435 0.2638
Schistosoma mansoni tyrosine kinase 0.022 0.1745 0.3009
Echinococcus granulosus protein kinase 0.0155 0.1074 0.1074
Trichomonas vaginalis AGC family protein kinase 0.0147 0.0995 0.3793
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0123 0.0755 0.3258
Loa Loa (eye worm) hypothetical protein 0.0057 0.0078 0.0085
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0147 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0057 0.0078 0.0085
Loa Loa (eye worm) SRC-1 0.022 0.1745 0.189
Trichomonas vaginalis STE family protein kinase 0.0087 0.038 0.1413
Giardia lamblia Kinase, PLK 0.0273 0.2285 1
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Entamoeba histolytica protein kinase, putative 0.0065 0.0156 0.0413
Echinococcus multilocularis SH2 domain containing protein 7 0.0055 0.0056 0.0067
Loa Loa (eye worm) hypothetical protein 0.0145 0.0979 0.1061
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0102 0.0533 0.0578
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0086 0.0374 0.0405
Echinococcus multilocularis tyrosine protein kinase Src42A 0.022 0.1745 0.2112
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.035 0.0604
Trypanosoma cruzi polo-like protein kinase, putative 0.0273 0.2285 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0453 0.4117 0.4461
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0055 0.0056 0.006
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0146 0.0988 0.0988
Trypanosoma brucei protein kinase, putative 0.0078 0.0293 0.1076
Schistosoma mansoni nck2/grb4 0.0086 0.0374 0.0645
Echinococcus multilocularis casein kinase I alpha 0.011 0.0614 0.0743
Echinococcus multilocularis myosin iiia 0.0085 0.0366 0.0443
Loa Loa (eye worm) TK protein kinase 0.0265 0.2199 0.2383
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0517 0.056
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0158 0.111 0.1344
Echinococcus granulosus epidermal growth factor receptor 0.0617 0.5798 0.5798
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0146 0.0986 0.1193
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0158 0.111 1
Echinococcus granulosus Vam6:Vps39 protein 0.0113 0.065 0.065
Echinococcus granulosus casein kinase I alpha 0.011 0.0614 0.0614
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.0995 0.2874
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0205 0.1586 0.1718
Trichomonas vaginalis AGC family protein kinase 0.019 0.1438 0.551
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.009 0.0415 0.1548
Loa Loa (eye worm) hypothetical protein 0.0113 0.065 0.0704
Echinococcus multilocularis PAK box P21 Rho binding 0.0065 0.0156 0.0189
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Loa Loa (eye worm) hypothetical protein 0.0141 0.093 0.1007
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0101 0.0526 0.4664
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0203 0.1566 0.1566
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0074 0.0255 0.0276
Loa Loa (eye worm) hypothetical protein 0.0087 0.0382 0.0414
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0102 0.0533 0.4733
Plasmodium falciparum serine/threonine protein kinase, putative 0.0147 0.0995 0.8948
Brugia malayi Temporarily assigned gene name protein 59 0.0131 0.0829 0.0898
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0401 0.3593 0.3593
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0084 0.035 0.0379
Brugia malayi Protein kinase domain containing protein 0.01 0.0517 0.056
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0114 0.0659 0.0659
Onchocerca volvulus 0.01 0.0517 0.1389
Echinococcus granulosus cyclin dependent kinase 5 0.012 0.0719 0.0719
Brugia malayi Protein kinase domain containing protein 0.0082 0.0333 0.0361
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0157 0.1102 0.4206
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0166 0.1187 0.1437
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0113 0.065 0.0787
Brugia malayi serine/threonine-protein kinase PAK 7 0.0235 0.189 0.2048
Entamoeba histolytica casein kinase, putative 0.0101 0.0526 0.1498
Loa Loa (eye worm) hypothetical protein 0.0243 0.1974 0.2138
Plasmodium falciparum protein serine/threonine kinase-1 0.0155 0.1079 0.9718
Brugia malayi C1-like domain containing protein 0.022 0.1741 0.1886
Loa Loa (eye worm) hypothetical protein 0.0113 0.065 0.0704
Brugia malayi Protein kinase domain containing protein 0.0288 0.2435 0.2638
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Schistosoma mansoni serine/threonine-protein kinase 0.0167 0.1203 0.2074
Echinococcus granulosus casein kinase i 0.011 0.0614 0.0614
Brugia malayi Stress-activated protein kinase jnk-1 0.0267 0.2223 0.2409
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0371 0.3283 0.3557
Trichomonas vaginalis AGC family protein kinase 0.0147 0.0995 0.3793
Trichomonas vaginalis CAMK family protein kinase 0.0273 0.2285 0.8788
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0419 0.1563
Echinococcus granulosus protein kinase c epsilon type 0.0213 0.1673 0.1673
Loa Loa (eye worm) TK/EGFR protein kinase 0.0617 0.5798 0.6282
Loa Loa (eye worm) SH2 domain-containing protein 0.0055 0.0056 0.006
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0188 0.1412 0.1709
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0078 0.0293 0.1224
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1079 0.1861
Echinococcus multilocularis serine:threonine protein kinase 0.0115 0.0671 0.0812
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0055 0.0056 0.0056
Schistosoma mansoni suppressor of cytokine signaling 0.0055 0.0056 0.0096
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0097 0.0488 0.0591
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0102 0.0533 0.0646
Leishmania major protein kinase, putative 0.0102 0.0533 0.2283
Schistosoma mansoni protein kinase 0.0195 0.1484 0.256
Echinococcus granulosus nervana 2 0.0125 0.0773 0.0773
Echinococcus multilocularis 0.0055 0.0056 0.0067
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0078 0.0293 0.1116
Echinococcus granulosus protein kinase c iota type 0.0296 0.2517 0.2517
Brugia malayi Immunoglobulin I-set domain containing protein 0.0088 0.0398 0.0432
Echinococcus multilocularis serine:threonine protein kinase N2 0.0301 0.2568 0.3108
Schistosoma mansoni serine/threonine protein kinase 0.017 0.1227 0.2116
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0071 0.0223 0.027
Echinococcus multilocularis myotubularin protein 13 0.0051 0.002 0.0024
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.022 0.1745 0.2112
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0882 0.1522
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0236 0.1901 0.1901
Brugia malayi Variant SH3 domain containing protein 0.0097 0.0488 0.0529
Loa Loa (eye worm) hypothetical protein 0.009 0.0418 0.0453
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.05 0.4602 0.557
Entamoeba histolytica protein kinase, putative 0.0082 0.0333 0.0933
Entamoeba histolytica protein kinase, putative 0.017 0.1227 0.3555
Giardia lamblia Kinase, CAMK CAMKL 0.009 0.0415 0.1762
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Schistosoma mansoni tyrosine kinase 0.0079 0.03 0.0517
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0797 0.3029
Echinococcus granulosus signal transduction protein lnk realted 0.0055 0.0056 0.0056
Brugia malayi Protein kinase domain containing protein 0.0155 0.1079 0.1169
Brugia malayi Variant SH3 domain containing protein 0.0065 0.0161 0.0175
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Schistosoma mansoni nephrin 0.0107 0.0592 0.1021
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0273 0.2285 0.2285
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0114 0.0659 0.2838
Echinococcus granulosus tyrosine protein kinase Srms 0.0513 0.4732 0.4732
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0102 0.0533 0.2006
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0155 0.1079 0.4688
Schistosoma mansoni protein kinase 0.0087 0.038 0.0656
Echinococcus granulosus hypothetical protein 0.0055 0.0056 0.0056
Echinococcus multilocularis casein kinase i 0.011 0.0614 0.0743
Trichomonas vaginalis CAMK family protein kinase 0.0128 0.0797 0.3029
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Brugia malayi Sex muscle abnormal protein 5 0.0086 0.0374 0.0405
Brugia malayi Immunoglobulin I-set domain containing protein 0.0265 0.2199 0.2383
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0205 0.1586 0.1718
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0118 0.0701 0.076
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0238 0.192 0.192
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0137 0.0898 0.8066
Schistosoma mansoni hypothetical protein 0.0103 0.0548 0.0945
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0113 0.065 0.2797
Loa Loa (eye worm) hypothetical protein 0.006 0.0109 0.0119
Entamoeba histolytica hypothetical protein 0.0123 0.0755 0.2169
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0953 0.9229 1
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.017 0.1227 0.1485
Echinococcus granulosus SH2 motif 0.0055 0.0056 0.0056
Echinococcus granulosus cGMP dependent protein kinase 1 0.0136 0.0882 0.0882
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0123 0.0755 0.0818
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0082 0.0328 0.286
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0113 0.065 0.2458
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0147 0.0995 0.2874
Echinococcus granulosus tensin 0.0055 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0103 0.0548 0.0945
Trichomonas vaginalis STE family protein kinase 0.0065 0.0156 0.0545
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Loa Loa (eye worm) hypothetical protein 0.0106 0.058 0.0628
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0218 0.1724 0.2087
Schistosoma mansoni serine/threonine protein kinase 0.0188 0.1412 0.2435
Leishmania major protein kinase A catalytic subunit isoform 2 0.0114 0.0659 0.2838
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0084 0.035 0.1344
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Loa Loa (eye worm) AGC/AKT protein kinase 0.0304 0.2598 0.2815
Echinococcus multilocularis casein kinase ii subunit alpha 0.0101 0.0526 0.0636
Trypanosoma cruzi casein kinase, delta isoform, putative 0.011 0.0614 0.2639
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0439 0.3977 0.3977
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.022 0.1741 0.1886
Onchocerca volvulus 0.0091 0.0419 0.1093
Echinococcus multilocularis cyclin dependent kinase 1 0.012 0.0719 0.087
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.1724 0.2974
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.0187 0.0203
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0055 0.0056 0.0096
Entamoeba histolytica protein kinase, putative 0.0123 0.0755 0.2169
Echinococcus granulosus protein kinase shaggy 0.013 0.0821 0.0821
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0415 0.0716
Trypanosoma cruzi polo-like protein kinase, putative 0.0273 0.2285 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0102 0.0533 0.4733
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Loa Loa (eye worm) TK/ABL protein kinase 0.01 0.0517 0.056
Entamoeba histolytica protein kinase, putative 0.014 0.0928 0.2677
Loa Loa (eye worm) CAMK/PKD protein kinase 0.022 0.1741 0.1886
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0454 0.17
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0526 0.1977
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.006
Onchocerca volvulus 0.0196 0.1496 0.4336
Brugia malayi Pleckstrin Homology Domain 0.0051 0.002 0.0021
Onchocerca volvulus 0.0296 0.2515 0.7404
Echinococcus multilocularis Immunoglobulin 0.0073 0.0236 0.0286
Echinococcus granulosus casein kinase I delta 0.011 0.0614 0.0614
Giardia lamblia Kinase, STE STE20 0.0087 0.038 0.1608
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0102 0.0533 0.0578
Brugia malayi Protein kinase domain containing protein 0.0115 0.0671 0.0727
Echinococcus granulosus SHC transforming protein 3 0.0055 0.0056 0.0056
Echinococcus granulosus CDC7 cell division cycle 7 0.0091 0.0419 0.0419
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0195 0.1484 0.1608
Loa Loa (eye worm) TK/FER protein kinase 0.0407 0.3654 0.3959
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0178 0.1308 0.1418
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0094 0.0454 0.1934
Trypanosoma cruzi Protein kinase B 0.0167 0.1203 0.5231
Onchocerca volvulus 0.0065 0.0157 0.0304
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.014 0.0928 0.402
Entamoeba histolytica protein kinase domain containing protein 0.013 0.0821 0.2364
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0084 0.035 0.1475
Echinococcus multilocularis dual specificity 0.014 0.0928 0.1123
Giardia lamblia Kinase, CMGC CLK 0.0155 0.1079 0.4688
Giardia lamblia Kinase, NEK 0.0137 0.0898 0.3891
Loa Loa (eye worm) SH2 domain-containing protein 0.0055 0.0056 0.006
Plasmodium falciparum casein kinase 1 0.011 0.0614 0.5471
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.006
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0155 0.1079 0.412
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0155 0.1079 0.4273
Loa Loa (eye worm) hypothetical protein 0.0115 0.0671 0.0727
Loa Loa (eye worm) AGC/PKA protein kinase 0.0114 0.0659 0.0714
Onchocerca volvulus 0.0113 0.065 0.1789
Brugia malayi Immunoglobulin I-set domain containing protein 0.0449 0.4076 0.4416
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0094 0.0454 0.0492
Brugia malayi Protein kinase domain containing protein 0.01 0.0517 0.056
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0055 0.0056 0.0096
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0146 0.0987 0.0987
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0526 0.1977
Brugia malayi probable protein kinase 0.0268 0.2229 0.2416
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0719 0.124
Trichomonas vaginalis AGC family protein kinase 0.0147 0.0995 0.3793
Toxoplasma gondii AGC kinase 0.0114 0.0659 0.2587
Brugia malayi serine/threonine kinase 12 0.0147 0.0995 0.1078
Echinococcus multilocularis cyclin dependent kinase 0.012 0.0719 0.087
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0055 0.0056 0.006
Brugia malayi Cam kinase protein 1 0.0102 0.0533 0.0578
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0114 0.0659 0.2494
Loa Loa (eye worm) hypothetical protein 0.0362 0.3192 0.3459
Echinococcus multilocularis expressed protein 0.0084 0.035 0.0424
Loa Loa (eye worm) hypothetical protein 0.0607 0.5694 0.617
Echinococcus multilocularis SH2 motif 0.0055 0.0056 0.0067
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0188 0.1412 0.153
Trypanosoma cruzi casein kinase, putative 0.011 0.0614 0.2639
Brugia malayi Protein kinase domain containing protein 0.01 0.0517 0.056
Brugia malayi hypothetical protein 0.0088 0.0398 0.0432
Onchocerca volvulus 0.0077 0.0277 0.0667
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0469 0.4279 0.4279
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0158 0.111 0.4824
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0219 0.1734 0.1879
Echinococcus granulosus serine:threonine protein kinase N2 0.0131 0.0835 0.0835
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0161 0.1136 0.1231
Brugia malayi Casein kinase II, alpha chain 0.0101 0.0526 0.057
Echinococcus multilocularis casein kinase I gamma 0.0216 0.1695 0.2052
Echinococcus multilocularis SH2 motif 0.0055 0.0056 0.0067
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.192 0.3312
Brugia malayi protein kinase C3,putative 0.0159 0.1121 0.1215
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0517 0.056
Schistosoma mansoni growth factor receptor-bound protein 0.0086 0.0374 0.0645
Brugia malayi cell division control protein 2 homolog 0.012 0.0719 0.0779
Brugia malayi hypothetical protein 0.0225 0.1788 0.1937
Loa Loa (eye worm) hypothetical protein 0.0102 0.0533 0.0578
Echinococcus multilocularis protein kinase c iota type 0.0296 0.2517 0.3046
Schistosoma mansoni serine/threonine-protein kinase 0.0167 0.1203 0.2074
Giardia lamblia Kinase, STE STE20 0.0085 0.0366 0.1546
Echinococcus granulosus tyrosine protein kinase HCK 0.0134 0.0866 0.0866
Brugia malayi Doublecortin family protein 0.0152 0.105 0.1138
Onchocerca volvulus 0.01 0.0517 0.1389
Loa Loa (eye worm) hypothetical protein 0.0187 0.1404 0.1521
Brugia malayi Protein kinase domain containing protein 0.0123 0.0755 0.0818
Echinococcus granulosus suppressor of cytokine signaling 6 0.0055 0.0056 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0882 0.1522
Brugia malayi Protein kinase domain containing protein 0.0454 0.4128 0.4473
Echinococcus granulosus epidermal growth factor receptor 0.0407 0.3646 0.3646
Trichomonas vaginalis AGC family protein kinase 0.0304 0.2598 1
Leishmania major protein kinase A catalytic subunit isoform 1 0.0114 0.0659 0.2838
Entamoeba histolytica SH2 domain containing protein 0.0055 0.0056 0.0119
Echinococcus multilocularis tensin 0.0055 0.0056 0.0067
Schistosoma mansoni suppressor of cytokine signaling 0.0055 0.0056 0.0096
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0175 0.0175
Echinococcus multilocularis ephrin type A receptor 4 A 0.011 0.0618 0.0748
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.009 0.0415 0.3653
Echinococcus multilocularis dual specificity protein kinase clk2 0.0155 0.1079 0.1306
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0094 0.0454 0.1763
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.0054 0.0043 0.0108
Schistosoma mansoni serine/threonine kinase 0.017 0.1227 0.2116
Trypanosoma cruzi casein kinase, putative 0.011 0.0614 0.2639
Trichomonas vaginalis CMGC family protein kinase 0.012 0.0719 0.2725
Entamoeba histolytica protein kinase 2, putative 0.0158 0.111 0.3212
Echinococcus granulosus tyrosine protein kinase Blk 0.0189 0.1427 0.1427
Toxoplasma gondii AGC kinase 0.0114 0.0659 0.2587
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0102 0.0533 0.0533
Brugia malayi hypothetical protein 0.0055 0.0056 0.006
Entamoeba histolytica protein kinase, putative 0.0102 0.0533 0.152
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0517 0.056
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0055 0.0056 0.0056
Echinococcus multilocularis cyclin dependent kinase 1 0.012 0.0719 0.087
Leishmania major casein kinase II, putative 0.0101 0.0526 0.225
Brugia malayi cytokine inducible SH2-containing protein 5 0.0055 0.0056 0.006
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0055 0.0056 0.0067
Onchocerca volvulus 0.011 0.0614 0.1681
Brugia malayi Temporarily assigned gene name protein 59 0.0113 0.065 0.0704
Echinococcus granulosus mitogen activated protein kinase 14 0.0161 0.1136 0.1136
Schistosoma mansoni serine/threonine protein kinase 0.0253 0.2082 0.3592
Entamoeba histolytica protein kinase, putative 0.0074 0.0248 0.0684
Brugia malayi SRC-1 0.022 0.1745 0.189
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0419 0.1563
Echinococcus granulosus casein kinase I alpha 0.011 0.0614 0.0614
Schistosoma mansoni shc transforming protein 0.0055 0.0056 0.0096
Schistosoma mansoni tyrosine kinase 0.0131 0.0835 0.144
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0125 0.0773 0.0773
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.006
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0165 0.1184 0.1283
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.0995 0.1716
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0114 0.0659 0.5883
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0114 0.0659 0.0798
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0454 0.0783
Schistosoma mansoni serine/threonine protein kinase 0.0203 0.1566 0.2702
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0025 0.0043
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0155 0.1079 0.1169
Echinococcus granulosus NDR protein kinase 0.017 0.1227 0.1227
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0073 0.0236 0.0408
Onchocerca volvulus 0.0141 0.093 0.263
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0114 0.0659 0.2587
Echinococcus granulosus serine:threonine protein kinase 0.0115 0.0671 0.0671
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0114 0.0659 0.5883
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1079 0.1861
Loa Loa (eye worm) hypothetical protein 0.0065 0.0157 0.017
Loa Loa (eye worm) hypothetical protein 0.0082 0.0337 0.0365
Brugia malayi Hr1 repeat family protein 0.0301 0.2568 0.2782
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0136 0.0882 0.1068
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0109 0.0119
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0136 0.0882 0.1068
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0166 0.1187 0.1286
Echinococcus multilocularis casein kinase I alpha 0.011 0.0614 0.0743
Echinococcus granulosus activin receptor type 0.0078 0.0293 0.0293
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.022 0.1745 0.2112
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0225 0.1788 0.1937
Plasmodium falciparum NIMA related kinase 1 0.0137 0.0898 0.8066
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0337 0.2938 0.3184
Echinococcus granulosus mitogen activated protein kinase 0.0094 0.0454 0.0454
Echinococcus granulosus fibroblast growth factor receptor 4 0.0246 0.2006 0.2006
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0064 0.015 0.0181
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.0681 0.2577
Echinococcus granulosus casein kinase I delta 0.011 0.0614 0.0614
Trichomonas vaginalis CAMK family protein kinase 0.0273 0.2285 0.8788
Schistosoma mansoni serine/threonine protein kinase 0.017 0.1227 0.2116
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Echinococcus granulosus suppressor of cytokine signaling 7 0.0055 0.0056 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.0681 0.2577
Onchocerca volvulus Tyrosine kinase homolog 0.038 0.3378 1
Entamoeba histolytica cell division protein kinase 2, putative 0.012 0.0719 0.2065
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0213 0.1673 0.1812
Trichomonas vaginalis AGC family protein kinase 0.0199 0.1531 0.5868
Schistosoma mansoni serine/threonine protein kinase 0.0483 0.4422 0.7627
Echinococcus multilocularis roundabout 2 0.0122 0.0742 0.0898
Entamoeba histolytica protein kinase, putative 0.0074 0.0248 0.0684
Entamoeba histolytica p21-activated kinase 0.0096 0.0473 0.1342
Brugia malayi casein kinase I 0.011 0.0614 0.0666
Schistosoma mansoni protein kinase 0.0236 0.1901 0.3278
Schistosoma mansoni titin 0.0068 0.0187 0.0323
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0113 0.065 0.2797
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.006
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0449 0.4076 0.4416
Loa Loa (eye worm) AGC/NDR protein kinase 0.017 0.1227 0.133
Echinococcus multilocularis titin 0.0068 0.0187 0.0226
Brugia malayi Protein kinase domain containing protein 0.0607 0.5694 0.617
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0885 0.1526
Loa Loa (eye worm) hypothetical protein 0.0122 0.0742 0.0804
Echinococcus granulosus dual specificity 0.014 0.0928 0.0928
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0055 0.0056 0.0056
Echinococcus granulosus rho-associated protein kinase 1 0.0329 0.2852 0.2852
Brugia malayi Protein kinase domain containing protein 0.0371 0.3283 0.3557
Entamoeba histolytica protein kinase, putative 0.0304 0.2598 0.7577
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.192 0.3312
Echinococcus multilocularis epidermal growth factor receptor 0.0407 0.3646 0.4413
Echinococcus multilocularis tyrosine protein kinase Fyn 0.022 0.1745 0.2112
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0082 0.0328 0.1258
Trichomonas vaginalis STE family protein kinase 0.0087 0.038 0.1413
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0255 0.2097 0.2097
Entamoeba histolytica PH domain containing protein kinase, putative 0.0123 0.0752 0.2161
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0371 0.3283 0.3283
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0085 0.0366 0.1546
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.022 0.1745 0.2112
Schistosoma mansoni tyrosine kinase 0.0361 0.3184 0.5492
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Echinococcus granulosus ephrin type A receptor 4 A 0.011 0.0618 0.0618
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0158 0.111 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0167 0.1203 0.3483
Entamoeba histolytica protein kinase domain containing protein 0.0205 0.1586 0.4607
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0102 0.0533 0.0578
Trichomonas vaginalis CAMK family protein kinase 0.0273 0.2285 0.8788
Entamoeba histolytica protein kinase domain containing protein 0.0123 0.0755 0.2169
Schistosoma mansoni hypothetical protein 0.0113 0.065 0.1121
Onchocerca volvulus 0.01 0.0517 0.1389
Trypanosoma brucei cdc2-related kinase 1 0.012 0.0719 0.2725
Echinococcus multilocularis SHC transforming protein 3 0.0055 0.0056 0.0067
Onchocerca volvulus 0.01 0.0517 0.1389
Entamoeba histolytica casein kinase 1, putative 0.011 0.0614 0.1757
Schistosoma mansoni GTPase activating protein 0.0055 0.0056 0.0096
Schistosoma mansoni serine/threonine protein kinase 0.0329 0.2852 0.492
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0337 0.2938 0.3184
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0399 0.3566 0.4317
Brugia malayi P38 map kinase family protein 2 0.0161 0.1136 0.1231
Echinococcus multilocularis tyrosine protein kinase Fyn 0.022 0.1745 0.2112
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0928 0.3533
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0085 0.0366 0.1029
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0082 0.0337 0.0365
Plasmodium vivax protein kinase, putative 0.006 0.0112 0.0886
Schistosoma mansoni vam6/vps39 related 0.0113 0.065 0.1121
Schistosoma mansoni tensin 0.0055 0.0056 0.0096
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0123 0.0755 0.3258
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0267 0.2223 0.2409
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0928 0.3533
Echinococcus multilocularis SH2 motif 0.0055 0.0056 0.0067
Echinococcus multilocularis protein kinase shaggy 0.013 0.0821 0.0994
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0147 0.0995 0.1204
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0389 0.067
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Trypanosoma cruzi SNF1-related protein kinases, putative 0.009 0.0415 0.1762
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0087 0.038 0.046
Brugia malayi Kinase associated domain 1 family protein 0.0103 0.0548 0.0594
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0235 0.1893 0.1893
Schistosoma mansoni SH2A 0.0055 0.0056 0.0096
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.009 0.0415 0.1762
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0087 0.038 0.046
Echinococcus multilocularis rho associated protein kinase 0.0329 0.2852 0.3452
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0659 0.1137
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0357 0.3136 0.3796
Echinococcus multilocularis NCK adaptor protein 0.0088 0.0394 0.0477
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0146 0.0987 0.1195
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0109 0.0119
Brugia malayi SH2 domain containing protein 0.0055 0.0056 0.006
Echinococcus granulosus defective proboscis extension response 0.0073 0.0236 0.0236
Plasmodium vivax serine/threonine protein kinase, putative 0.0084 0.035 0.3058
Echinococcus granulosus tyrosine protein kinase Fyn 0.022 0.1745 0.1745
Loa Loa (eye worm) hypothetical protein 0.0141 0.093 0.1007
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0526 0.1977
Loa Loa (eye worm) hypothetical protein 0.0235 0.1893 0.2051
Trichomonas vaginalis AGC family protein kinase 0.017 0.1227 0.4692
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0155 0.1079 0.4688
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0064 0.015 0.015
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0127 0.0794 0.3429
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Loa Loa (eye worm) hypothetical protein 0.0073 0.0236 0.0256
Echinococcus multilocularis tyrosine protein kinase Fyn 0.022 0.1745 0.2112
Loa Loa (eye worm) hypothetical protein 0.0183 0.1362 0.1476
Schistosoma mansoni tensin 0.0055 0.0056 0.0096
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0055 0.0056 0.0067
Brugia malayi Tensin 0.0055 0.0056 0.006
Loa Loa (eye worm) TK/ROR protein kinase 0.0064 0.015 0.0162
Echinococcus granulosus Immunoglobulin 0.0073 0.0236 0.0236
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0526 0.1977
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0114 0.0659 0.0798
Schistosoma mansoni serine/threonine protein kinase 0.0399 0.3566 0.6151
Schistosoma mansoni signal transduction protein lnk-related 0.0055 0.0056 0.0096
Echinococcus granulosus tyrosine protein kinase Fyn 0.022 0.1745 0.1745
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0187 0.0323
Trypanosoma brucei rac serine-threonine kinase, putative 0.0304 0.2598 1
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Echinococcus multilocularis c src tyrosine kinase 0.0131 0.0835 0.1011
Schistosoma mansoni tensin-related 0.0055 0.0056 0.0096
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0073 0.0236 0.0286
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0087 0.038 0.038
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0235 0.189 0.2048
Schistosoma mansoni tyrosine kinase 0.0453 0.4117 0.7101
Onchocerca volvulus Serine\/threonine kinase homolog 0.0166 0.1187 0.3406
Trypanosoma cruzi cdc2-related kinase 1 0.012 0.0719 0.3101
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0077 0.0277 0.1155
Schistosoma mansoni hypothetical protein 0.0055 0.0056 0.0096
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0599 0.1032
Brugia malayi Protein kinase domain containing protein 0.0196 0.1494 0.1619
Trichomonas vaginalis AGC family protein kinase 0.0304 0.2598 1
Echinococcus granulosus protein kinase C gamma type 0.0211 0.165 0.165
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Echinococcus multilocularis calcium dependent protein kinase 0.0069 0.0197 0.0238
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0097 0.0488 0.0529
Toxoplasma gondii aurora kinase 0.0147 0.0995 0.3934
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0218 0.1724 0.1724
Trypanosoma cruzi cdc2-related kinase 3 0.012 0.0719 0.3101
Brugia malayi SH2 domain containing protein 0.0055 0.0056 0.006
Echinococcus granulosus tyrosine protein kinase Src42A 0.022 0.1745 0.1745
Plasmodium falciparum protein kinase, putative 0.0078 0.0293 0.2537
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0123 0.0755 0.3258
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0357 0.3136 0.3398
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0928 0.3533
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0928 0.3533
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.022 0.1745 0.1745
Loa Loa (eye worm) AUR protein kinase 0.0147 0.0995 0.1078
Loa Loa (eye worm) AGC/PKN protein kinase 0.0301 0.2568 0.2782
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0158 0.111 0.111
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0273 0.2285 0.2476
Schistosoma mansoni tyrosine kinase 0.0407 0.3646 0.6288
Echinococcus granulosus tyrosine protein kinase Src64B 0.022 0.1745 0.1745
Trypanosoma brucei cdc2-related kinase 3 0.012 0.0719 0.2725
Schistosoma mansoni vesicular amine transporter 0.0073 0.0236 0.0408
Leishmania major protein kinase, putative 0.0155 0.1079 0.4688
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.014 0.0928 0.402
Trichomonas vaginalis AGC family protein kinase 0.0304 0.2598 1
Brugia malayi Protein kinase domain containing protein 0.0195 0.1484 0.1608
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.012 0.0719 0.3101
Entamoeba histolytica protein kinase, putative 0.0071 0.0223 0.061
Trichomonas vaginalis AGC family protein kinase 0.0082 0.0333 0.1231
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0419 0.0722
Giardia lamblia Kinase, AGC PKA 0.0114 0.0659 0.2838
Loa Loa (eye worm) AUR protein kinase 0.0147 0.0995 0.1078
Schistosoma mansoni vav2 0.0106 0.058 0.1001
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0526 0.1977
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.006
Entamoeba histolytica protein kinase, putative 0.0088 0.0392 0.1107
Onchocerca volvulus 0.0329 0.2852 0.8417
Brugia malayi Protein kinase domain containing protein 0.01 0.0517 0.056
Echinococcus multilocularis cyclin dependent kinase 5 0.012 0.0719 0.087
Entamoeba histolytica protein kinase domain containing protein 0.014 0.0928 0.2677
Brugia malayi phosphoinositide-dependent protein kinase I 0.0082 0.0333 0.0361
Echinococcus multilocularis tyrosine protein kinase Fgr 0.022 0.1745 0.2112
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.014 0.0928 0.1005
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0147 0.0995 0.2874
Schistosoma mansoni protein kinase 0.0101 0.0526 0.0907
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.014 0.0928 0.3533
Echinococcus multilocularis rac serine:threonine kinase 0.0167 0.1203 0.1456
Loa Loa (eye worm) hypothetical protein 0.0145 0.0971 0.1053
Echinococcus multilocularis hypothetical protein 0.0103 0.0548 0.0663
Loa Loa (eye worm) STAT protein 0.0055 0.0056 0.006
Echinococcus granulosus growth factor receptor bound protein 2 0.0088 0.0394 0.0394
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0068 0.0187 0.0203
Echinococcus multilocularis aurora kinase A 0.0147 0.0995 0.1204
Echinococcus granulosus expressed conserved protein 0.0055 0.0056 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0056 0.0096
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0236 0.1901 0.23
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.006
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0607 0.5694 0.617
Onchocerca volvulus 0.01 0.0517 0.1389
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0349 0.3062 0.3318
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0517 0.056
Echinococcus granulosus tyrosine protein kinase 0.0288 0.2435 0.2435
Echinococcus multilocularis mitogen activated protein kinase 0.0094 0.0454 0.055
Brugia malayi hypothetical protein 0.0057 0.0078 0.0085
Echinococcus multilocularis Immunoglobulin 0.0073 0.0236 0.0286
Loa Loa (eye worm) SH2 domain-containing protein 0.0055 0.0056 0.006
Entamoeba histolytica protein kinase, putative 0.0071 0.0223 0.061
Echinococcus granulosus mitogen activated protein kinase 3 0.0094 0.0454 0.0454
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0885 0.1526
Brugia malayi Protein kinase domain containing protein 0.0191 0.1441 0.1561
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0454 0.17
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0255 0.2097 0.2272
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.012 0.0719 0.2826
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0188 0.1412 0.1412
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0116 0.0681 0.0824
Schistosoma mansoni protein kinase 0.0439 0.3977 0.6859
Echinococcus granulosus glycogen synthase kinase 3 beta 0.013 0.0821 0.0821
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0131 0.0835 0.144
Echinococcus multilocularis nervana 2 0.0125 0.0773 0.0936
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Trichomonas vaginalis CAMK family protein kinase 0.0273 0.2285 0.8788
Brugia malayi Protein kinase domain containing protein 0.019 0.1438 0.1559
Echinococcus multilocularis mitogen activated protein kinase 14 0.0161 0.1136 0.1375
Loa Loa (eye worm) hypothetical protein 0.009 0.0418 0.0453
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Echinococcus multilocularis mitogen activated protein kinase 14 0.0161 0.1136 0.1375
Brugia malayi MAP kinase sur-1 0.0094 0.0454 0.0492
Loa Loa (eye worm) TK/FAK protein kinase 0.0564 0.5251 0.569
Trichomonas vaginalis CAMK family protein kinase 0.0219 0.1734 0.6655
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0273 0.2285 1
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0073 0.0236 0.0408
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0469 0.4279 0.5179
Echinococcus multilocularis calcium activated potassium channel 0.0136 0.0885 0.1071
Echinococcus granulosus SH2 motif 0.0055 0.0056 0.0056
Onchocerca volvulus 0.0316 0.2723 0.8029
Giardia lamblia Kinase, CDC7 0.0091 0.0419 0.1778
Echinococcus granulosus insulin receptor 0.0453 0.4117 0.4117
Entamoeba histolytica protein kinase, putative 0.0087 0.038 0.107
Brugia malayi Protein kinase domain containing protein 0.0357 0.3136 0.3398
Brugia malayi Protein kinase domain containing protein 0.01 0.0517 0.056
Echinococcus multilocularis mitogen activated protein kinase 3 0.0094 0.0454 0.055
Echinococcus multilocularis tyrosine protein kinase HCK 0.0134 0.0866 0.1048
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.014 0.0928 0.3664
Plasmodium vivax casein kinase 1, putative 0.011 0.0614 0.5471
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0113 0.065 0.065
Echinococcus granulosus tyrosine kinase 0.01 0.0517 0.0517
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0614 0.1059
Brugia malayi map kinase activated protein kinase protein 2 0.0399 0.3566 0.3864
Loa Loa (eye worm) hypothetical protein 0.0196 0.1496 0.1621
Loa Loa (eye worm) CMGC/GSK protein kinase 0.013 0.0821 0.089
Leishmania major casein kinase, putative 0.011 0.0614 0.2639
Schistosoma mansoni protein kinase 0.0078 0.0293 0.0505
Plasmodium falciparum glycogen synthase kinase 3 0.013 0.0821 0.736
Echinococcus multilocularis serine:threonine kinase SAD 1 0.009 0.0415 0.0502
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.0454 0.17
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0255 0.2097 0.2538
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0081 0.0323 0.0323
Loa Loa (eye worm) CAMK protein kinase 0.0068 0.0187 0.0203
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.013 0.0821 0.355
Toxoplasma gondii CMGC kinase, CK2 family 0.0101 0.0526 0.2051
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0454 0.4128 0.4473
Brugia malayi Protein kinase domain containing protein 0.0084 0.035 0.0379
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0928 0.16
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0205 0.1586 0.1586
Schistosoma mansoni protein kinase 0.011 0.0614 0.1059
Schistosoma mansoni tyrosine kinase 0.0453 0.4117 0.7101
Giardia lamblia Kinase, CMGC DYRK 0.014 0.0928 0.402
Giardia lamblia Kinase, AGC AKT 0.0118 0.0701 0.3022
Trypanosoma cruzi casein kinase, putative 0.011 0.0614 0.2639
Echinococcus granulosus serine:threonine protein kinase 0.0115 0.0671 0.0671
Echinococcus granulosus cGMP dependent protein kinase 1 0.0136 0.0882 0.0882
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0113 0.065 0.1121
Trypanosoma cruzi aurora B kinase, putative 0.0147 0.0995 0.4316
Echinococcus multilocularis serine:threonine protein kinase N2 0.017 0.1227 0.1485
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0357 0.3136 0.9271
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0123 0.0755 0.2863
Loa Loa (eye worm) hypothetical protein 0.0362 0.3192 0.3459
Loa Loa (eye worm) hypothetical protein 0.0054 0.0043 0.0047
Loa Loa (eye worm) hypothetical protein 0.0055 0.0056 0.006
Plasmodium vivax unspecified product 0.0101 0.0526 0.4664
Trichomonas vaginalis CK1 family protein kinase 0.011 0.0614 0.2319
Echinococcus multilocularis epidermal growth factor receptor 0.0617 0.5798 0.7018
Echinococcus granulosus dual specificity 0.014 0.0928 0.0928
Brugia malayi hypothetical protein 0.0113 0.065 0.0704
Schistosoma mansoni serine/threonine protein kinase 0.0253 0.2082 0.3592
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0071 0.0223 0.0223
Plasmodium vivax serine/threonine kinase-1, putative 0.0155 0.1079 0.9718
Schistosoma mansoni serine/threonine protein kinase 0.0205 0.1586 0.2735
Loa Loa (eye worm) protein kinase domain-containing protein 0.0216 0.1695 0.1837
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0086 0.0374 0.0645
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0155 0.1079 0.412
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0415 0.0716
Echinococcus multilocularis casein kinase I delta 0.011 0.0614 0.0743
Schistosoma mansoni protein kinase 0.0439 0.3977 0.6859
Loa Loa (eye worm) TK/FER protein kinase 0.01 0.0517 0.056
Plasmodium falciparum protein kinase 5 0.012 0.0719 0.6429
Schistosoma mansoni ste20-related kinase 0.0207 0.1612 0.278
Giardia lamblia Kinase, CAMK CAMKL 0.009 0.0415 0.1762
Giardia lamblia Kinase, CMGC GSK 0.013 0.0821 0.355
Loa Loa (eye worm) hypothetical protein 0.0086 0.0374 0.0405
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.013 0.0821 0.0994
Brugia malayi ephrin receptor 1 precursor 0.0076 0.0268 0.0291
Entamoeba histolytica protein kinase, putative 0.0295 0.2506 0.7306
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.017 0.1227 0.1485
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.0054 0.0043 0.0108
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.012 0.0719 0.0779
Echinococcus multilocularis serine:threonine protein kinase 3 0.026 0.2146 0.2598
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0063 0.0135 0.0465
Echinococcus multilocularis serine threonine protein kinase 0.0211 0.165 0.1997
Echinococcus granulosus raf serine:threonine protein kinase 0.0088 0.0389 0.0389
Schistosoma mansoni protein kinase 0.0236 0.1901 0.3278
Giardia lamblia Aurora kinase 0.0147 0.0995 0.4316
Echinococcus multilocularis growth factor receptor bound protein 2 0.0086 0.0374 0.0452
Brugia malayi SH2 domain containing protein 0.0055 0.0056 0.006
Entamoeba histolytica protein kinase, putative 0.0147 0.0995 0.2874
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0167 0.1203 0.5231
Echinococcus granulosus roundabout 2 0.0122 0.0742 0.0742
Trichomonas vaginalis AGC family protein kinase 0.019 0.1438 0.551
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0246 0.2006 0.2006
Trichomonas vaginalis AGC family protein kinase 0.0082 0.0333 0.1231
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0055 0.0056 0.006
Trichomonas vaginalis CMGC family protein kinase 0.012 0.0719 0.2725
Trichomonas vaginalis AGC family protein kinase 0.0082 0.0333 0.1231
Echinococcus granulosus c src tyrosine kinase 0.0131 0.0835 0.0835
Plasmodium falciparum serine/threonine protein kinase KIN 0.009 0.0415 0.3653
Leishmania major protein kinase, putative 0.0078 0.0293 0.1224
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0078 0.0293 0.1076
Brugia malayi Protein kinase domain containing protein 0.0216 0.1695 0.1837
Brugia malayi Protein kinase domain containing protein 0.0453 0.4117 0.4461
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0055 0.0056 0.0067
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0114 0.0659 0.0798
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0102 0.0533 0.4733
Entamoeba histolytica protein kinase, putative 0.0123 0.0755 0.2169
Echinococcus granulosus c-Jun N-terminal kinases 0.0267 0.2223 0.2223
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0043 0.0108
Trichomonas vaginalis CK1 family protein kinase 0.011 0.0614 0.2319
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0101 0.0526 0.057
Onchocerca volvulus Serine\/threonine kinase homolog 0.0273 0.2285 0.671
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.019 0.1438 0.1559
Loa Loa (eye worm) hypothetical protein 0.0141 0.093 0.1007
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0203 0.1566 0.1697
Giardia lamblia Kinase, CK1 Casein kinase 0.011 0.0614 0.2639
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0085 0.0366 0.1358
Plasmodium vivax calcium-dependent protein kinase, putative 0.0102 0.0533 0.4733
Trichomonas vaginalis STE family protein kinase 0.0087 0.038 0.1413
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0082 0.0333 0.0361
Loa Loa (eye worm) hypothetical protein 0.0051 0.002 0.0021
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0084 0.035 0.1475
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0218 0.1724 0.2087
Brugia malayi Protein kinase domain containing protein 0.0953 0.9229 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0155 0.1079 0.4688
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0114 0.0659 0.0659
Giardia lamblia Kinase, CMGC GSK 0.013 0.0821 0.355
Brugia malayi Protein kinase domain containing protein 0.0564 0.5251 0.569
Echinococcus multilocularis insulin receptor 0.0453 0.4117 0.4983
Echinococcus granulosus serine:threonine protein kinase N2 0.0301 0.2568 0.2568
Onchocerca volvulus 0.0066 0.0171 0.0346
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Echinococcus multilocularis tyrosine protein kinase Srms 0.0189 0.1427 0.1727
Echinococcus granulosus titin 0.0068 0.0187 0.0187
Plasmodium falciparum calcium-dependent protein kinase 2 0.0102 0.0533 0.4733
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0928 0.3533
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.1724 0.2974
Trichomonas vaginalis CAMK family protein kinase 0.0273 0.2285 0.8788
Brugia malayi serine/threonine-protein kinase plk-2 0.0273 0.2285 0.2476
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0102 0.0533 0.0533
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0071 0.0223 0.0223
Schistosoma mansoni serine/threonine protein kinase 0.0216 0.1695 0.2924
Entamoeba histolytica protein kinase, putative 0.0304 0.2598 0.7577
Echinococcus granulosus Protein kinase C brain isozyme 0.0253 0.2082 0.2082
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0371 0.3283 0.3973
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0055 0.0056 0.006
Trichomonas vaginalis AGC family protein kinase 0.0304 0.2598 1
Schistosoma mansoni serine/threonine protein kinase 0.0357 0.3136 0.5409
Plasmodium falciparum calcium-dependent protein kinase 3 0.0102 0.0533 0.4733
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0407 0.3646 0.3646
Loa Loa (eye worm) hypothetical protein 0.0088 0.0398 0.0432
Echinococcus granulosus tyrosine kinase 0.0189 0.1427 0.1427
Plasmodium falciparum casein kinase 2, alpha subunit 0.0101 0.0526 0.4664
Trypanosoma cruzi p21-activated kinase 3, putative 0.0055 0.0056 0.0179
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0097 0.0488 0.0488
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0152 0.105 0.1138
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0188 0.1412 0.153
Loa Loa (eye worm) hypothetical protein 0.012 0.0725 0.0785
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0223 0.0385
Loa Loa (eye worm) casein kinase 0.0183 0.1359 0.1472
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0155 0.1074 0.1164
Entamoeba histolytica PH domain containing protein kinase, putative 0.0167 0.1203 0.3483
Schistosoma mansoni tyrosine kinase 0.0361 0.3184 0.5492
Entamoeba histolytica protein kinase, putative 0.0084 0.035 0.0982
Onchocerca volvulus 0.0145 0.0971 0.2756
Trichomonas vaginalis CMGC family protein kinase 0.0091 0.0419 0.1563
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0115 0.0671 0.0727
Brugia malayi protein-tyrosine kinase 0.0189 0.1427 0.1546
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0189 0.1427 0.1727
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0161 0.1136 0.4938
Loa Loa (eye worm) hypothetical protein 0.0106 0.058 0.0628
Entamoeba histolytica protein kinase , putative 0.0147 0.0995 0.2874
Schistosoma mansoni tyrosine kinase 0.0131 0.0835 0.144
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0055 0.0056 0.0067
Brugia malayi protein unc-22 0.0068 0.0187 0.0203
Brugia malayi SH2 domain containing protein 0.0055 0.0056 0.006
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0087 0.0386 0.0386
Schistosoma mansoni adapter molecule crk 0.0086 0.0374 0.0645
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0071 0.0223 0.027
Echinococcus granulosus neuroglian 0.0092 0.043 0.043
Entamoeba histolytica protein kinase domain containing protein 0.0101 0.0526 0.1498
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0082 0.0333 0.0403
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.011 0.0614 0.0666
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0719 0.124
Schistosoma mansoni rap gtpase-activating protein 0.0113 0.065 0.1121
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0085 0.0366 0.1029
Schistosoma mansoni serine/threonine protein kinase 0.0255 0.2097 0.3616
Onchocerca volvulus 0.0091 0.0419 0.1093
Brugia malayi Variant SH3 domain containing protein 0.0086 0.0374 0.0405
Entamoeba histolytica PH domain containing protein kinase, putative 0.0123 0.0752 0.2161
Echinococcus multilocularis dual specificity 0.0123 0.0755 0.0913
Echinococcus granulosus calcium activated potassium channel 0.0136 0.0885 0.0885
Brugia malayi SH2 domain containing protein 0.0055 0.0056 0.006
Trypanosoma brucei Casein kinase II 0.0101 0.0526 0.1977
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0082 0.0333 0.0333
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0928 0.3533
Entamoeba histolytica protein kinase domain containing protein 0.0078 0.0293 0.0815
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0147 0.0995 0.8948
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0155 0.1079 0.4688
Echinococcus multilocularis raf serine:threonine protein kinase 0.0088 0.0389 0.047
Echinococcus granulosus serine:threonine kinase SAD 1 0.009 0.0415 0.0415
Echinococcus granulosus cGMP dependent protein kinase 0.0136 0.0882 0.0882
Echinococcus multilocularis tyrosine protein kinase shark 0.0316 0.2725 0.3298
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0203 0.1566 0.1896
Schistosoma mansoni serine/threonine protein kinase 0.0273 0.2285 0.3941
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0114 0.0659 0.2838
Schistosoma mansoni tyrosine kinase 0.0407 0.3646 0.6288
Brugia malayi p70 ribosomal S6 kinase beta 0.0295 0.2506 0.2715
Echinococcus multilocularis neuroglian 0.0092 0.043 0.052
Entamoeba histolytica serine/threonine protein kinase, putative 0.009 0.0415 0.1173
Echinococcus granulosus dual specificity protein kinase clk2 0.0155 0.1079 0.1079
Echinococcus multilocularis twitchin 0.0052 0.0025 0.003
Echinococcus granulosus casein kinase ii subunit alpha 0.0101 0.0526 0.0526
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Brugia malayi intracellular kinase 0.013 0.0821 0.089
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0055 0.0056 0.0056
Entamoeba histolytica SH2-protein kinase domain containing protein 0.01 0.0517 0.1472
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0273 0.2285 0.2766
Trichomonas vaginalis CAMK family protein kinase 0.0273 0.2285 0.8788
Echinococcus multilocularis serine:threonine protein kinase N2 0.0131 0.0835 0.1011
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.026 0.2146 0.2325
Echinococcus granulosus tyrosine protein kinase Lyn 0.0253 0.2081 0.2081
Schistosoma mansoni protein kinase 0.0087 0.038 0.0656
Schistosoma mansoni lipoxygenase 0.0067 0.0175 0.0303
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.012 0.0719 0.0719
Loa Loa (eye worm) TK/EPH protein kinase 0.0128 0.08 0.0866
Echinococcus granulosus dual specificity 0.014 0.0928 0.0928
Entamoeba histolytica protein kinase, putative 0.0147 0.0995 0.2874
Loa Loa (eye worm) hypothetical protein 0.0073 0.0236 0.0256
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0898 0.3419
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.022 0.1745 0.1745
Echinococcus multilocularis tyrosine protein kinase Blk 0.0189 0.1427 0.1727
Onchocerca volvulus 0.013 0.0821 0.2304
Loa Loa (eye worm) hypothetical protein 0.0103 0.0548 0.0594
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0125 0.0773 0.0936
Trichomonas vaginalis CMGC family protein kinase 0.0101 0.0526 0.1977
Loa Loa (eye worm) hypothetical protein 0.0114 0.0659 0.0714
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0114 0.0659 0.0659
Onchocerca volvulus 0.0068 0.0187 0.0395
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0253 0.2082 0.2521
Brugia malayi Protein kinase domain containing protein 0.0304 0.2598 0.2815
Giardia lamblia Kinase, AGC PKA 0.0158 0.111 0.4824
Echinococcus granulosus cyclin dependent kinase 1 0.012 0.0719 0.0719
Echinococcus granulosus twitchin 0.0125 0.0767 0.0767
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0407 0.3654 0.3654
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0094 0.0454 0.1934
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0225 0.1788 0.1788
Trichomonas vaginalis CMGC family protein kinase 0.013 0.0821 0.312
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0094 0.0454 0.1934
Schistosoma mansoni serine/threonine protein kinase 0.0258 0.2127 0.3669
Trypanosoma brucei polo-like protein kinase 0.0273 0.2285 0.8788
Brugia malayi Fes/CIP4 homology domain containing protein 0.0108 0.0597 0.0647
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Echinococcus multilocularis death associated protein kinase 1 0.0859 0.8262 1
Echinococcus multilocularis dual specificity 0.014 0.0928 0.1123
Brugia malayi hypothetical protein 0.01 0.0517 0.056
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0415 0.1548
Trypanosoma brucei SNF1-related protein kinases, putative 0.009 0.0415 0.1548
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0094 0.0454 0.1934
Brugia malayi Protein kinase domain containing protein 0.0062 0.0131 0.0141
Brugia malayi Protein kinase domain containing protein 0.0166 0.1187 0.1286
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0146 0.0988 0.1196
Schistosoma mansoni serine/threonine protein kinase 0.0301 0.2568 0.4428
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Toxoplasma gondii histone kinase SNF1, putative 0.009 0.0415 0.1606
Brugia malayi putative serine/threonine kinase SADA gamma 0.009 0.0415 0.045
Echinococcus granulosus NCK adaptor protein 0.0086 0.0374 0.0374
Toxoplasma gondii casein kinase I 0.011 0.0614 0.2405
Echinococcus multilocularis expressed conserved protein 0.0136 0.0882 0.1068
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0135 0.0465
Loa Loa (eye worm) thyroid receptor interactor 0.0108 0.0597 0.0647
Echinococcus granulosus SH2 domain containing protein 7 0.0055 0.0056 0.0056
Trypanosoma brucei casein kinase I, isoform 2 0.011 0.0614 0.2319
Brugia malayi protein kinase C II. 0.0213 0.1673 0.1812
Schistosoma mansoni tensin-related 0.0055 0.0056 0.0096
Schistosoma mansoni protein kinase C mu 0.022 0.1741 0.3002
Schistosoma mansoni serine/threonine protein kinase 0.0267 0.2223 0.3834
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0094 0.0454 0.17
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0082 0.0333 0.0361
Echinococcus granulosus cyclin dependent kinase 0.012 0.0719 0.0719
Entamoeba histolytica protein kinase domain containing protein 0.013 0.0821 0.2364
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0238 0.192 0.2325
Echinococcus multilocularis protein kinase c epsilon type 0.0213 0.1673 0.2024
Schistosoma mansoni growth factor receptor-bound protein 0.0088 0.0394 0.068
Echinococcus multilocularis 0.0155 0.1074 0.13
Plasmodium falciparum calcium-dependent protein kinase 1 0.0102 0.0533 0.4733
Brugia malayi Variant SH3 domain containing protein 0.0086 0.0374 0.0405
Echinococcus multilocularis protein tyrosine kinase 0.0558 0.5189 0.6281
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.012 0.0719 0.0779
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0116 0.0681 0.0681
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0114 0.0659 0.0798
Loa Loa (eye worm) hypothetical protein 0.0064 0.0148 0.016
Echinococcus granulosus tyrosine protein kinase Fyn 0.022 0.1745 0.1745
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0659 0.1137
Echinococcus granulosus casein kinase I alpha 0.011 0.0614 0.0614
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0097 0.0488 0.0842
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0671 0.2538
Echinococcus granulosus aurora kinase A 0.0147 0.0995 0.0995
Trichomonas vaginalis AGC family protein kinase 0.0304 0.2598 1
Trypanosoma brucei protein kinase, putative 0.0094 0.0454 0.17
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0087 0.038 0.046
Giardia lamblia Kinase, NEK 0.0137 0.0898 0.3891
Entamoeba histolytica protein kinase, putative 0.013 0.0821 0.2364
Loa Loa (eye worm) AGC/PKG protein kinase 0.0136 0.0882 0.0956
Schistosoma mansoni protein kinase 0.0155 0.1074 0.1853
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0161 0.1136 0.4938
Echinococcus granulosus nervana 2 0.0125 0.0773 0.0773
Trichomonas vaginalis CMGC family protein kinase 0.013 0.0821 0.312
Trichomonas vaginalis STE family protein kinase 0.0087 0.038 0.1413
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0102 0.0533 0.2081
Leishmania major protein kinase, putative 0.0155 0.1079 0.4688
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0659 0.1137
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0114 0.0659 0.2838

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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