Detailed information for compound 1360806

Basic information

Technical information
  • TDR Targets ID: 1360806
  • Name: 2-[[4-ethyl-5-(2-methylfuran-3-yl)-1,2,4-tria zol-3-yl]sulfanyl]-N-(4-methyl-1,2,5-oxadiazo l-3-yl)acetamide
  • MW: 348.38 | Formula: C14H16N6O3S
  • H donors: 1 H acceptors: 5 LogP: 1.16 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c(SCC(=O)Nc2nonc2C)nnc1c1ccoc1C
  • InChi: 1S/C14H16N6O3S/c1-4-20-13(10-5-6-22-9(10)3)16-17-14(20)24-7-11(21)15-12-8(2)18-23-19-12/h5-6H,4,7H2,1-3H3,(H,15,19,21)
  • InChiKey: VWTURHSBXHYSAL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[4-ethyl-5-(2-methyl-3-furyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-methyl-1,2,5-oxadiazol-3-yl)acetamide
  • 2-[[4-ethyl-5-(2-methyl-3-furyl)-1,2,4-triazol-3-yl]thio]-N-(4-methyl-1,2,5-oxadiazol-3-yl)acetamide
  • 2-[[4-ethyl-5-(2-methyl-3-furyl)-1,2,4-triazol-3-yl]thio]-N-(4-methylfurazan-3-yl)acetamide
  • 2-[[4-ethyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-(4-methyl-1,2,5-oxadiazol-3-yl)ethanamide
  • SMR000005745
  • 2-[4-Ethyl-5-(2-methyl-furan-3-yl)-4H-[1,2,4]triazol-3-ylsulfanyl]-N-(4-methyl-furazan-3-yl)-acetamide
  • MLS000032577
  • ASN 05919124
  • ZINC04411602

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.014 0.0913 0.0991
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0337 0.1291
Entamoeba histolytica protein kinase, putative 0.0129 0.0802 0.2354
Loa Loa (eye worm) AGC/PKA protein kinase 0.0113 0.064 0.0695
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0082 0.0314 0.0381
Echinococcus granulosus c-Jun N-terminal kinases 0.0266 0.2203 0.2203
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0219 0.1721 0.1869
Toxoplasma gondii aurora kinase 0.0146 0.0975 0.3324
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0084 0.0337 0.0211
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0334 0.2896 0.3146
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0397 0.3545 0.3851
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0137 0.0879 0.2852
Plasmodium falciparum protein kinase 5 0.0119 0.07 0.5082
Echinococcus multilocularis cyclin dependent kinase 5 0.0119 0.07 0.0849
Loa Loa (eye worm) hypothetical protein 0.021 0.163 0.177
Brugia malayi Protein kinase domain containing protein 0.0083 0.0331 0.0359
Echinococcus granulosus tyrosine protein kinase Blk 0.0157 0.1089 0.1089
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0129 0.0802 0.2569
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0396 0.0683
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.009 0.0396 0.2861
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0085 0.0347 0.0239
Trypanosoma brucei casein kinase I, isoform 2 0.0109 0.0595 0.1399
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0234 0.1875 0.1875
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0086 0.0361 0.0361
Trichomonas vaginalis STE family protein kinase 0.0086 0.0361 0.1389
Echinococcus granulosus ephrin type A receptor 4 A 0.0112 0.0623 0.0623
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0113 0.0633 0.1579
Brugia malayi serine/threonine kinase 12 0.0146 0.0975 0.106
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0085 0.0347 0.1018
Trichomonas vaginalis CMGC family protein kinase 0.009 0.04 0.155
Schistosoma mansoni vam6/vps39 related 0.0113 0.0633 0.1092
Schistosoma mansoni serine/threonine protein kinase 0.0328 0.2832 0.4882
Brugia malayi hypothetical protein 0.0113 0.0633 0.0688
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0355 0.3115 0.3384
Echinococcus multilocularis CDC7 cell division cycle 7 0.009 0.04 0.0485
Echinococcus granulosus cGMP dependent protein kinase 1 0.0135 0.0863 0.0863
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0123 0.0735 0.2232
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0337 0.1291
Loa Loa (eye worm) hypothetical protein 0.009 0.0401 0.0436
Brugia malayi Protein kinase domain containing protein 0.0165 0.1168 0.1268
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0093 0.0432 0.0745
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0129 0.0802 0.2474
Schistosoma mansoni protein kinase 0.0146 0.0975 0.1682
Schistosoma mansoni serine/threonine protein kinase 0.024 0.1932 0.333
Entamoeba histolytica serine/threonine protein kinase, putative 0.0272 0.2265 0.665
Brugia malayi Protein kinase domain containing protein 0.0098 0.0483 0.0525
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.2203 0.3798
Trichomonas vaginalis AGC family protein kinase 0.0164 0.1155 0.4689
Echinococcus granulosus serine:threonine protein kinase 0.0115 0.0651 0.0651
Echinococcus multilocularis dual specificity 0.014 0.0908 0.1102
Echinococcus granulosus serine:threonine protein kinase N2 0.0131 0.0818 0.0818
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0113 0.0633 0.1092
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0154 0.106 0.4591
Schistosoma mansoni protein kinase 0.0064 0.0137 0.0236
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0127 0.0774 0.2429
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.1917 0.3306
Entamoeba histolytica protein kinase, putative 0.0071 0.0204 0.0599
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0101 0.0514 0.1068
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0072 0.022 0.0379
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.106 0.1827
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0337 0.1291
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0129 0.0802 0.1382
Schistosoma mansoni tyrosine kinase 0.036 0.3166 0.5458
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0123 0.0735 0.2056
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0397 0.3545 0.4304
Loa Loa (eye worm) hypothetical protein 0.0101 0.0514 0.0558
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0113 0.064 0.064
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0084 0.0334 0.0981
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.009 0.0396 0.0468
Entamoeba histolytica protein kinase, putative 0.0073 0.0229 0.0673
Entamoeba histolytica hypothetical protein 0.0123 0.0735 0.2159
Brugia malayi serine/threonine-protein kinase PAK 7 0.0234 0.187 0.2032
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0084 0.0337 0.0366
Echinococcus multilocularis cyclin dependent kinase 1 0.0119 0.07 0.0849
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.016 0.1116 0.4845
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0217 0.1704 0.1704
Loa Loa (eye worm) hypothetical protein 0.0145 0.0962 0.1045
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0407 0.3649 0.3649
Echinococcus granulosus serine:threonine protein kinase N2 0.0286 0.2402 0.2402
Leishmania major casein kinase II, putative 0.01 0.0507 0.107
Echinococcus multilocularis cyclin dependent kinase 1 0.0119 0.07 0.0849
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0061 0.0105 0.0115
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.008 0.0296 0.1163
Echinococcus granulosus casein kinase I delta 0.0109 0.0595 0.0595
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.1445 0.1445
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0055 0.0037 0.0042
Echinococcus multilocularis serine:threonine protein kinase N2 0.0131 0.0818 0.0993
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0234 0.187 0.2032
Loa Loa (eye worm) TK/INSR protein kinase 0.0454 0.412 0.4476
Schistosoma mansoni protein kinase 0.0086 0.0361 0.0622
Echinococcus multilocularis Immunoglobulin 0.0072 0.022 0.0267
Brugia malayi protein-tyrosine kinase 0.0157 0.1089 0.1183
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0908 0.3663
Entamoeba histolytica protein kinase, putative 0.028 0.234 0.6872
Brugia malayi Protein kinase domain containing protein 0.0115 0.0651 0.0707
Brugia malayi P38 map kinase family protein 2 0.016 0.1116 0.1213
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0071 0.0204 0.0204
Echinococcus granulosus protein kinase c epsilon type 0.0198 0.1508 0.1508
Trichomonas vaginalis AGC family protein kinase 0.0146 0.0975 0.3943
Onchocerca volvulus 0.0098 0.0483 0.1429
Loa Loa (eye worm) AGC/AKT protein kinase 0.0289 0.2433 0.2643
Echinococcus multilocularis 0.0154 0.1055 0.128
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0192 0.1445 0.1445
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0192 0.1445 0.1445
Loa Loa (eye worm) TK protein kinase 0.0354 0.3097 0.3364
Brugia malayi Protein kinase domain containing protein 0.0062 0.0111 0.0121
Plasmodium falciparum calcium-dependent protein kinase 1 0.0101 0.0514 0.2747
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0507 0.1994
Loa Loa (eye worm) hypothetical protein 0.0072 0.022 0.0239
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0204 0.1566 0.1701
Schistosoma mansoni serine/threonine protein kinase 0.0165 0.1168 0.2013
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0355 0.3115 0.3781
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0101 0.0514 0.0558
Echinococcus multilocularis PAK box P21 Rho binding 0.0064 0.0137 0.0166
Echinococcus multilocularis activin receptor type 0.008 0.0296 0.0359
Onchocerca volvulus 0.0069 0.019 0.0561
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0217 0.1704 0.2068
Loa Loa (eye worm) TK/FER protein kinase 0.0098 0.0483 0.0525
Onchocerca volvulus 0.0295 0.2498 0.7386
Echinococcus granulosus titin 0.0067 0.0168 0.0168
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0437 0.3956 0.3956
Echinococcus granulosus cyclin dependent kinase 5 0.0119 0.07 0.07
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0113 0.064 0.2707
Schistosoma mansoni serine/threonine protein kinase 0.0397 0.3545 0.6113
Schistosoma mansoni tyrosine kinase 0.0081 0.0305 0.0525
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.008 0.0296 0.1163
Echinococcus granulosus protein tyrosine kinase 0.0558 0.5192 0.5192
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0204 0.1566 0.1701
Brugia malayi Protein kinase domain containing protein 0.0194 0.1464 0.1591
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0093 0.0432 0.0432
Entamoeba histolytica protein kinase, putative 0.014 0.0908 0.2666
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0224 0.1768 0.1768
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0507 0.1994
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0272 0.2265 0.246
Giardia lamblia Kinase, CK1 Casein kinase 0.0109 0.0595 0.1365
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0158 0.1091 0.1091
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0507 0.1994
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.024 0.1932 0.1932
Brugia malayi Variant SH3 domain containing protein 0.0061 0.0105 0.0115
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0595 0.1026
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0119 0.07 0.2051
Giardia lamblia Kinase, AGC AKT 0.0118 0.0682 0.1815
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0336 0.292 0.3172
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0355 0.3115 0.3384
Brugia malayi putative serine/threonine kinase SADA gamma 0.009 0.0396 0.043
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0115 0.0651 0.0707
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.0661 0.2637
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0202 0.1546 0.1546
Loa Loa (eye worm) hypothetical protein 0.0072 0.022 0.0239
Trichomonas vaginalis AGC family protein kinase 0.0289 0.2433 1
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0154 0.106 0.3574
Trypanosoma cruzi casein kinase, putative 0.0109 0.0595 0.2505
Entamoeba histolytica protein kinase, putative 0.0083 0.0331 0.0971
Loa Loa (eye worm) hypothetical protein 0.0082 0.032 0.0348
Brugia malayi Temporarily assigned gene name protein 59 0.013 0.0812 0.0882
Entamoeba histolytica protein kinase, putative 0.0289 0.2433 0.7143
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0055 0.0037 0.004
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0135 0.0863 0.2774
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0863 0.1488
Trichomonas vaginalis AGC family protein kinase 0.0155 0.1063 0.4305
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0113 0.064 0.0777
Brugia malayi map kinase activated protein kinase protein 2 0.0397 0.3545 0.3851
Loa Loa (eye worm) hypothetical protein 0.0065 0.014 0.0152
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0113 0.064 0.1611
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0192 0.1445 0.1754
Schistosoma mansoni serine/threonine protein kinase 0.0481 0.4401 0.7587
Echinococcus granulosus roundabout 2 0.0122 0.0725 0.0725
Schistosoma mansoni tyrosine kinase 0.0192 0.1445 0.2491
Loa Loa (eye worm) TK/FER protein kinase 0.0098 0.0483 0.0525
Loa Loa (eye worm) thyroid receptor interactor 0.0111 0.0619 0.0672
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0122 0.0728 0.2916
Schistosoma mansoni serine/threonine protein kinase 0.0237 0.19 0.3276
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0113 0.064 0.0777
Echinococcus multilocularis calcium dependent protein kinase 0.0069 0.018 0.0218
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.07 0.2797
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0507 0.1994
Brugia malayi ephrin receptor 1 precursor 0.0078 0.0273 0.0297
Schistosoma mansoni protein kinase 0.037 0.3262 0.5624
Entamoeba histolytica p21-activated kinase 0.0095 0.0453 0.1331
Loa Loa (eye worm) TK protein kinase 0.0266 0.2204 0.2394
Schistosoma mansoni serine/threonine protein kinase 0.0165 0.1168 0.2013
Schistosoma mansoni adapter molecule crk 0.0086 0.0356 0.0614
Loa Loa (eye worm) TK protein kinase 0.0157 0.1089 0.1183
Trichomonas vaginalis CAMK family protein kinase 0.0272 0.2265 0.9302
Loa Loa (eye worm) TK protein kinase 0.0289 0.2439 0.265
Echinococcus granulosus cyclin dependent kinase 1 0.0119 0.07 0.07
Brugia malayi Protein kinase domain containing protein 0.0605 0.5672 0.6162
Echinococcus granulosus nervana 2 0.0125 0.0756 0.0756
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0146 0.0975 0.0975
Giardia lamblia Kinase, CMGC CDK 0.0119 0.07 0.1907
Loa Loa (eye worm) SRC-1 0.0192 0.1445 0.157
Brugia malayi Variant SH3 domain containing protein 0.0086 0.0356 0.0387
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.0661 0.2637
Onchocerca volvulus Tyrosine kinase homolog 0.0381 0.3382 1
Brugia malayi Variant SH3 domain containing protein 0.0086 0.0356 0.0387
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Entamoeba histolytica protein kinase, putative 0.0123 0.0735 0.2159
Loa Loa (eye worm) hypothetical protein 0.0087 0.0366 0.0397
Schistosoma mansoni serine/threonine protein kinase 0.0257 0.2107 0.3633
Plasmodium vivax serine/threonine protein kinase, putative 0.0083 0.0331 0.2192
Schistosoma mansoni protein kinase 0.0086 0.0361 0.0622
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0337 0.0582
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0204 0.1566 0.1901
Echinococcus multilocularis tyrosine kinase 0.0098 0.0483 0.0586
Echinococcus multilocularis protein tyrosine kinase 0.0558 0.5192 0.6302
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0123 0.0735 0.3135
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0146 0.0969 0.1176
Trypanosoma cruzi polo-like protein kinase, putative 0.0272 0.2265 1
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.037 0.3262 0.3543
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0879 0.3542
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0605 0.5672 0.6162
Echinococcus granulosus hypothetical protein 0.0122 0.0726 0.0726
Echinococcus granulosus dual specificity 0.014 0.0908 0.0908
Brugia malayi Immunoglobulin I-set domain containing protein 0.045 0.4079 0.4431
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.016 0.1116 0.1213
Echinococcus granulosus titin 0.0067 0.0168 0.0168
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0125 0.0756 0.0756
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0204 0.1566 0.1566
Entamoeba histolytica protein kinase, putative 0.0289 0.2433 0.7143
Echinococcus multilocularis rho associated protein kinase 0.0328 0.2832 0.3437
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.1917 0.3306
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.037 0.3262 0.3262
Schistosoma mansoni serine/threonine-protein kinase 0.0167 0.1183 0.2039
Trypanosoma brucei rac serine-threonine kinase, putative 0.0289 0.2433 1
Giardia lamblia Kinase, NEK 0.0137 0.0879 0.2834
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0404 0.3618 0.4392
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.009 0.0396 0.0508
Loa Loa (eye worm) casein kinase 0.0121 0.072 0.0783
Brugia malayi hypothetical protein 0.0098 0.0483 0.0525
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0404 0.3618 0.3618
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.1547 0.2666
Onchocerca volvulus 0.0328 0.2832 0.8374
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0109 0.0595 0.0646
Loa Loa (eye worm) hypothetical protein 0.0605 0.5672 0.6162
Loa Loa (eye worm) hypothetical protein 0.0295 0.2497 0.2712
Loa Loa (eye worm) TK/FER protein kinase 0.0098 0.0483 0.0525
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0158 0.1091 0.1324
Echinococcus multilocularis tyrosine protein kinase HCK 0.0106 0.0568 0.0689
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.1445 0.1445
Loa Loa (eye worm) hypothetical protein 0.0357 0.3135 0.3406
Loa Loa (eye worm) hypothetical protein 0.0195 0.1479 0.1607
Echinococcus multilocularis serine:threonine protein kinase N2 0.0155 0.1063 0.129
Plasmodium falciparum casein kinase 1 0.0109 0.0595 0.3763
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.064 0.1103
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0098 0.0483 0.0586
Brugia malayi Protein kinase domain containing protein 0.0355 0.3115 0.3384
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0394 0.0679
Echinococcus granulosus c src tyrosine kinase 0.0133 0.0839 0.0839
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0101 0.0514 0.4076
Schistosoma mansoni vav2 0.0102 0.0525 0.0904
Loa Loa (eye worm) AUR protein kinase 0.0146 0.0975 0.106
Giardia lamblia Kinase, PLK 0.0272 0.2265 1
Echinococcus granulosus NCK adaptor protein 0.0086 0.0356 0.0356
Echinococcus multilocularis dual specificity 0.0123 0.0735 0.0892
Brugia malayi Casein kinase II, alpha chain 0.01 0.0507 0.055
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0224 0.1768 0.1921
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.037 0.3262 0.3959
Echinococcus multilocularis tyrosine protein kinase Abl 0.0133 0.0839 0.1019
Loa Loa (eye worm) hypothetical protein 0.0088 0.0382 0.0414
Trichomonas vaginalis AGC family protein kinase 0.0155 0.1063 0.4305
Entamoeba histolytica protein kinase, putative 0.0155 0.1063 0.312
Echinococcus granulosus casein kinase I alpha 0.0109 0.0595 0.0595
Echinococcus multilocularis Glutaredoxin protein 5 0.0125 0.0756 0.0918
Echinococcus multilocularis tyrosine protein kinase shark 0.0314 0.2689 0.3264
Loa Loa (eye worm) TK protein kinase 0.0106 0.0568 0.0617
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0865 0.1492
Onchocerca volvulus 0.0315 0.2705 0.7999
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0084 0.0337 0.0211
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0187 0.1392 0.1512
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0083 0.0331 0.0359
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0112 0.0627 0.0761
Echinococcus multilocularis rac serine:threonine kinase 0.0167 0.1183 0.1436
Schistosoma mansoni protein kinase 0.0437 0.3956 0.682
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0116 0.0661 0.0803
Echinococcus multilocularis tyrosine protein kinase Blk 0.0157 0.1089 0.1322
Brugia malayi Protein kinase domain containing protein 0.0098 0.0483 0.0525
Entamoeba histolytica protein kinase domain containing protein 0.0129 0.0802 0.2354
Schistosoma mansoni tyrosine kinase 0.0247 0.201 0.3466
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0137 0.0879 0.7825
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0119 0.07 0.076
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0238 0.1917 0.2328
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0202 0.1546 0.1877
Brugia malayi p70 ribosomal S6 kinase beta 0.028 0.234 0.2542
Giardia lamblia Kinase, STE STE20 0.0086 0.0361 0.0155
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0093 0.0432 0.0469
Loa Loa (eye worm) TK/FAK protein kinase 0.0564 0.5254 0.5707
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0469 0.4282 0.5198
Schistosoma mansoni serine/threonine protein kinase 0.0204 0.1566 0.27
Brugia malayi Egg laying defective protein 4 0.0135 0.0863 0.0937
Loa Loa (eye worm) hypothetical protein 0.0103 0.0531 0.0577
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0074 0.0235 0.0256
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0514 0.2026
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0101 0.0514 0.1068
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1063 0.1832
Brugia malayi Fibronectin type III domain containing protein 0.0088 0.0382 0.0414
Schistosoma mansoni growth factor receptor-bound protein 0.0088 0.0377 0.0649
Schistosoma mansoni tyrosine kinase 0.0618 0.58 1
Trichomonas vaginalis CAMK family protein kinase 0.0115 0.0651 0.2596
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.07 0.1206
Brugia malayi hypothetical protein 0.0057 0.0062 0.0067
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.014 0.0908 0.311
Onchocerca volvulus Serine\/threonine kinase homolog 0.0272 0.2265 0.6697
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0187 0.1392 0.1392
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0499 0.458 0.556
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0135 0.0863 0.1047
Trichomonas vaginalis AGC family protein kinase 0.0155 0.1063 0.4305
Entamoeba histolytica casein kinase 1, putative 0.0109 0.0595 0.1747
Schistosoma mansoni protein kinase 0.0437 0.3956 0.682
Onchocerca volvulus Serine\/threonine kinase homolog 0.0165 0.1168 0.3453
Echinococcus multilocularis serine:threonine protein kinase N2 0.0286 0.2402 0.2916
Echinococcus granulosus tyrosine protein kinase Lyn 0.0225 0.1779 0.1779
Trichomonas vaginalis CMGC family protein kinase 0.009 0.04 0.155
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.028 0.234 0.2542
Entamoeba histolytica casein kinase, putative 0.0109 0.0595 0.1747
Brugia malayi protein kinase C II. 0.0198 0.1508 0.1638
Schistosoma mansoni protein kinase C mu 0.0219 0.1721 0.2967
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0397 0.3545 0.3545
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0113 0.064 0.1611
Leishmania major protein kinase, putative 0.0101 0.0514 0.1109
Entamoeba histolytica casein kinase, putative 0.01 0.0507 0.1487
Loa Loa (eye worm) hypothetical protein 0.006 0.0092 0.01
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0146 0.0975 0.2864
Plasmodium falciparum glycogen synthase kinase 3 0.0129 0.0802 0.6365
Leishmania major protein kinase A catalytic subunit isoform 2 0.0113 0.064 0.1748
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0081 0.0309 0.0168
Loa Loa (eye worm) TK/EPH protein kinase 0.013 0.0805 0.0874
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0192 0.1445 0.1754
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0146 0.0975 0.2864
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0154 0.106 0.4591
Entamoeba histolytica protein kinase, putative 0.0123 0.0735 0.2159
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0101 0.0514 0.0624
Loa Loa (eye worm) hypothetical protein 0.009 0.0401 0.0436
Echinococcus multilocularis insulin receptor 0.0454 0.412 0.5001
Brugia malayi Protein kinase domain 0.0086 0.0361 0.0392
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0355 0.3115 0.3384
Plasmodium vivax unspecified product 0.01 0.0507 0.3998
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0066 0.0155 0.0155
Plasmodium falciparum NIMA related kinase 1 0.0137 0.0879 0.7337
Echinococcus granulosus tyrosine protein kinase shark 0.0314 0.2689 0.2689
Plasmodium falciparum cGMP-dependent protein kinase 0.0135 0.0863 0.7135
Leishmania major casein kinase, putative 0.0109 0.0595 0.1519
Echinococcus multilocularis dual specificity 0.014 0.0908 0.1102
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Giardia lamblia Kinase, AGC PKA 0.0158 0.1091 0.3928
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0083 0.0331 0.132
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0086 0.0356 0.0387
Trichomonas vaginalis CMGC family protein kinase 0.009 0.04 0.155
Entamoeba histolytica hypothetical protein 0.0384 0.3406 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0101 0.0514 0.1068
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0084 0.0337 0.1349
Schistosoma mansoni tyrosine kinase 0.0454 0.412 0.7104
Trichomonas vaginalis CAMK family protein kinase 0.0272 0.2265 0.9302
Loa Loa (eye worm) hypothetical protein 0.0051 0.0003 0.0003
Giardia lamblia Kinase, CMGC GSK 0.0129 0.0802 0.2435
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.1704 0.2938
Plasmodium vivax tyrosine kinase-like protein, putative 0.0081 0.0309 0.197
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0908 0.3663
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0037 0.0063
Leishmania major protein kinase, putative 0.0085 0.0347 0.0259
Trypanosoma cruzi casein kinase, putative 0.0109 0.0595 0.2505
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.1445 0.1754
Echinococcus granulosus mitogen activated protein kinase 3 0.0084 0.0337 0.0337
Trypanosoma brucei protein kinase, putative 0.0084 0.0337 0.0194
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0452 0.4107 0.4462
Leishmania major protein kinase, putative 0.0146 0.0975 0.3451
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0396 0.0683
Loa Loa (eye worm) TK/ROR protein kinase 0.0066 0.0155 0.0168
Echinococcus granulosus fibroblast growth factor receptor 4 0.0247 0.201 0.201
Entamoeba histolytica protein kinase, putative 0.0082 0.0314 0.0922
Schistosoma mansoni serine/threonine protein kinase 0.009 0.04 0.0689
Echinococcus multilocularis titin 0.0067 0.0168 0.0204
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0217 0.1704 0.2068
Schistosoma mansoni nck2/grb4 0.0086 0.0356 0.0614
Echinococcus multilocularis NCK adaptor protein 0.0088 0.0377 0.0457
Giardia lamblia Kinase, CDC7 0.009 0.04 0.0356
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0272 0.2265 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0145 0.0967 0.0967
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0101 0.0514 0.0624
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0084 0.0337 0.0194
Schistosoma mansoni serine/threonine kinase 0.0155 0.1063 0.1832
Trichomonas vaginalis CAMK family protein kinase 0.0272 0.2265 0.9302
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0109 0.0595 0.2505
Echinococcus multilocularis epidermal growth factor receptor 0.0407 0.3649 0.4429
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0908 0.3663
Loa Loa (eye worm) hypothetical protein 0.014 0.0913 0.0991
Loa Loa (eye worm) hypothetical protein 0.0106 0.0563 0.0611
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0355 0.3115 0.9212
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0217 0.1704 0.1704
Brugia malayi serine/threonine protein kinase 6 0.0146 0.0975 0.106
Echinococcus granulosus serine threonine protein kinase nrc 0.0158 0.1091 0.1091
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Trichomonas vaginalis AGC family protein kinase 0.0289 0.2433 1
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0165 0.1168 0.1268
Brugia malayi intracellular kinase 0.0129 0.0802 0.0871
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0218 0.1714 0.1862
Echinococcus granulosus growth factor receptor bound protein 2 0.0088 0.0377 0.0377
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0158 0.1091 1
Trypanosoma brucei cdc2-related kinase 3 0.0119 0.07 0.189
Schistosoma mansoni ephrin receptor 0.0112 0.0623 0.1074
Trichomonas vaginalis AGC family protein kinase 0.0082 0.0314 0.1194
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0084 0.0337 0.1349
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0119 0.07 0.076
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0084 0.0337 0.0203
Schistosoma mansoni serine/threonine kinase 0.0218 0.1714 0.2955
Echinococcus multilocularis twitchin 0.0052 0.0006 0.0007
Entamoeba histolytica PH domain containing protein kinase, putative 0.0123 0.0732 0.215
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Brugia malayi Protein kinase domain containing protein 0.0192 0.1445 0.157
Loa Loa (eye worm) hypothetical protein 0.012 0.0708 0.0769
Loa Loa (eye worm) TK/FER protein kinase 0.0098 0.0483 0.0525
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.07 0.2797
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0155 0.1063 0.1063
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0071 0.0204 0.0248
Trichomonas vaginalis STE family protein kinase 0.0086 0.0361 0.1389
Trypanosoma cruzi aurora B kinase, putative 0.0146 0.0975 0.4213
Loa Loa (eye worm) hypothetical protein 0.0098 0.0483 0.0525
Echinococcus multilocularis roundabout 2 0.0122 0.0725 0.088
Entamoeba histolytica protein kinase, putative 0.0073 0.0229 0.0673
Echinococcus multilocularis dual specificity protein kinase clk2 0.0154 0.106 0.1286
Echinococcus granulosus casein kinase I alpha 0.0109 0.0595 0.0595
Trypanosoma cruzi casein kinase, putative 0.0109 0.0595 0.2505
Echinococcus granulosus epidermal growth factor receptor 0.0618 0.58 0.58
Echinococcus granulosus tyrosine kinase 0.0098 0.0483 0.0483
Brugia malayi Doublecortin family protein 0.0152 0.1031 0.112
Trichomonas vaginalis AGC family protein kinase 0.0289 0.2433 1
Echinococcus multilocularis dual specificity 0.014 0.0908 0.1102
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0006 0.001
Leishmania major protein kinase A catalytic subunit 0.0113 0.064 0.1748
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0402 0.3596 0.4365
Giardia lamblia Kinase, CMGC DYRK 0.014 0.0908 0.2985
Loa Loa (eye worm) hypothetical protein 0.0054 0.0027 0.0029
Entamoeba histolytica protein kinase domain containing protein 0.0146 0.0975 0.2864
Loa Loa (eye worm) hypothetical protein 0.0466 0.4246 0.4613
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0101 0.0514 0.0558
Entamoeba histolytica protein kinase, putative 0.0106 0.0568 0.1667
Schistosoma mansoni tyrosine kinase 0.0263 0.2168 0.3738
Loa Loa (eye worm) protein kinase domain-containing protein 0.0154 0.1055 0.1146
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0177 0.1289 0.14
Brugia malayi Sex muscle abnormal protein 5 0.0086 0.0356 0.0387
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0865 0.1492
Trichomonas vaginalis AGC family protein kinase 0.0146 0.0975 0.3943
Entamoeba histolytica protein kinase domain containing protein 0.014 0.0908 0.2666
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0158 0.1091 0.4729
Brugia malayi serine/threonine-protein kinase 6 0.0146 0.0975 0.106
Loa Loa (eye worm) AUR protein kinase 0.0146 0.0975 0.106
Echinococcus granulosus Vam6:Vps39 protein 0.0113 0.0633 0.0633
Echinococcus multilocularis casein kinase I alpha 0.0109 0.0595 0.0722
Trichomonas vaginalis AGC family protein kinase 0.0082 0.0314 0.1194
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.01 0.0507 0.055
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0266 0.2203 0.2393
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0082 0.0314 0.0341
Echinococcus granulosus CDC7 cell division cycle 7 0.009 0.04 0.04
Schistosoma mansoni protein kinase 0.01 0.0507 0.0873
Entamoeba histolytica cell division protein kinase 2, putative 0.0119 0.07 0.2054
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.014 0.0908 0.0987
Schistosoma mansoni ste20-related kinase 0.0206 0.1592 0.2744
Entamoeba histolytica protein kinase, putative 0.0083 0.0331 0.0971
Trichomonas vaginalis STE family protein kinase 0.0086 0.0361 0.1389
Echinococcus granulosus rho-associated protein kinase 1 0.0328 0.2832 0.2832
Echinococcus granulosus protein kinase c iota type 0.0281 0.2351 0.2351
Trypanosoma cruzi SNF1-related protein kinases, putative 0.009 0.0396 0.1612
Echinococcus multilocularis mitogen activated protein kinase 11 0.016 0.1116 0.1355
Loa Loa (eye worm) hypothetical protein 0.0057 0.0062 0.0067
Brugia malayi Protein kinase domain containing protein 0.0098 0.0483 0.0525
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0224 0.1768 0.2146
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0129 0.0802 0.0871
Echinococcus granulosus tyrosine protein kinase ABL1 0.0098 0.0483 0.0483
Trypanosoma cruzi casein kinase, putative 0.0109 0.0595 0.2505
Echinococcus granulosus Immunoglobulin 0.0072 0.022 0.022
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0071 0.0204 0.0248
Brugia malayi Protein kinase domain containing protein 0.0098 0.0483 0.0525
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0237 0.19 0.19
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0168 0.0182
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0908 0.3663
Giardia lamblia Kinase, NEK 0.0137 0.0879 0.2834
Trichomonas vaginalis CAMK family protein kinase 0.0127 0.0778 0.3122
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0975 0.1682
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.07 0.1206
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Loa Loa (eye worm) TK/FER protein kinase 0.0098 0.0483 0.0525
Loa Loa (eye worm) TK/ABL protein kinase 0.0098 0.0483 0.0525
Loa Loa (eye worm) AGC/PKN protein kinase 0.0286 0.2402 0.261
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0336 0.292 0.3172
Loa Loa (eye worm) CAMK protein kinase 0.0067 0.0168 0.0182
Echinococcus granulosus activin receptor type 0.008 0.0296 0.0296
Echinococcus granulosus dual specificity protein kinase clk2 0.0154 0.106 0.106
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0605 0.5672 0.6162
Echinococcus granulosus casein kinase I delta 0.0109 0.0595 0.0595
Trypanosoma brucei polo-like protein kinase 0.0272 0.2265 0.9214
Echinococcus granulosus dual specificity 0.0123 0.0735 0.0735
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0066 0.0155 0.0188
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0113 0.064 0.2707
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0101 0.0514 0.0514
Entamoeba histolytica serine/threonine protein kinase, putative 0.009 0.0396 0.1162
Echinococcus granulosus tyrosine protein kinase Srms 0.051 0.4696 0.4696
Onchocerca volvulus 0.0109 0.0595 0.1759
Echinococcus multilocularis hypothetical protein 0.0103 0.0531 0.0645
Brugia malayi Stress-activated protein kinase jnk-1 0.0266 0.2203 0.2393
Toxoplasma gondii AGC kinase 0.0113 0.064 0.1683
Brugia malayi phosphoinositide-dependent protein kinase I 0.0082 0.0314 0.0341
Echinococcus granulosus protein kinase C gamma type 0.0196 0.1485 0.1485
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.009 0.0396 0.1612
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0081 0.0309 0.0065
Plasmodium vivax glycogen synthase kinase 3, putative 0.0129 0.0802 0.7031
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0154 0.106 0.4591
Brugia malayi Protein kinase domain containing protein 0.0454 0.412 0.4476
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0082 0.0318 0.0345
Loa Loa (eye worm) hypothetical protein 0.0088 0.0382 0.0414
Schistosoma mansoni protein kinase 0.0237 0.1902 0.328
Brugia malayi MAP kinase sur-1 0.0084 0.0337 0.0366
Schistosoma mansoni nephrin 0.0107 0.0575 0.0991
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0908 0.3663
Plasmodium falciparum calcium-dependent protein kinase 4 0.0101 0.0514 0.2747
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0086 0.0356 0.0614
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0109 0.0595 0.0646
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0192 0.1445 0.1754
Trypanosoma cruzi cdc2-related kinase 1 0.0119 0.07 0.2975
Brugia malayi Protein kinase domain containing protein 0.0123 0.0735 0.0799
Brugia malayi Protein kinase domain containing protein 0.095 0.9205 1
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0154 0.106 0.3574
Loa Loa (eye worm) AGC/PKA protein kinase 0.0113 0.064 0.0695
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.016 0.1116 0.384
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0082 0.0314 0.0314
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0113 0.064 0.2707
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.1508 0.2599
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0084 0.0337 0.1349
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.095 0.9205 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0272 0.2265 0.2749
Giardia lamblia Kinase, CMGC CK2 0.01 0.0507 0.0909
Loa Loa (eye worm) hypothetical protein 0.0186 0.1387 0.1506
Plasmodium falciparum protein serine/threonine kinase-1 0.0154 0.106 0.9612
Loa Loa (eye worm) hypothetical protein 0.0086 0.0356 0.0387
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0192 0.1445 0.1754
Echinococcus multilocularis myosin iiia 0.0085 0.0347 0.0421
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0266 0.2203 0.2674
Trypanosoma cruzi casein kinase, putative 0.0109 0.0595 0.2505
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0129 0.0802 0.3433
Loa Loa (eye worm) hypothetical protein 0.0144 0.0954 0.1037
Trypanosoma cruzi Protein kinase B 0.0167 0.1183 0.5144
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0113 0.0633 0.2677
Echinococcus granulosus defective proboscis extension response 0.0072 0.022 0.022
Echinococcus multilocularis protein kinase c epsilon type 0.0198 0.1508 0.183
Echinococcus multilocularis serine threonine protein kinase 0.0196 0.1485 0.1803
Echinococcus multilocularis casein kinase I alpha 0.0109 0.0595 0.0722
Brugia malayi Protein kinase domain containing protein 0.0289 0.2439 0.265
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0247 0.201 0.244
Echinococcus multilocularis mitogen activated protein kinase 0.0084 0.0337 0.0409
Echinococcus multilocularis expressed conserved protein 0.0135 0.0863 0.1047
Echinococcus multilocularis tyrosine protein kinase 0.0289 0.2439 0.2961
Entamoeba histolytica PH domain containing protein kinase, putative 0.0123 0.0732 0.215
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0083 0.0331 0.0164
Brugia malayi protein unc-22 0.0067 0.0168 0.0182
Echinococcus multilocularis raf serine:threonine protein kinase 0.0089 0.0394 0.0478
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0113 0.0633 0.1092
Echinococcus multilocularis protein kinase shaggy 0.0129 0.0802 0.0973
Brugia malayi Protein kinase domain containing protein 0.0564 0.5254 0.5707
Brugia malayi Protein kinase domain containing protein 0.0452 0.4107 0.4462
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0198 0.1508 0.1638
Echinococcus granulosus dual specificity 0.014 0.0908 0.0908
Echinococcus granulosus tyrosine protein kinase HCK 0.0106 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0057 0.0062 0.0067
Trichomonas vaginalis CAMK family protein kinase 0.0272 0.2265 0.9302
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0272 0.2265 0.2265
Onchocerca volvulus 0.0065 0.014 0.0414
Entamoeba histolytica protein kinase, putative 0.0101 0.0514 0.1509
Onchocerca volvulus 0.0067 0.0168 0.0496
Entamoeba histolytica PH domain containing protein kinase, putative 0.0167 0.1183 0.3473
Trichomonas vaginalis AGC family protein kinase 0.0146 0.0975 0.3943
Plasmodium falciparum calcium-dependent protein kinase 3 0.0101 0.0514 0.2747
Trichomonas vaginalis CMGC family protein kinase 0.0154 0.106 0.4293
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0158 0.1091 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0123 0.0735 0.0799
Loa Loa (eye worm) hypothetical protein 0.0357 0.3135 0.3406
Trypanosoma cruzi cdc2-related kinase 3 0.0119 0.07 0.2975
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0098 0.0483 0.1419
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0167 0.1183 0.5144
Trypanosoma brucei cdc2-related kinase 1 0.0119 0.07 0.189
Brugia malayi Protein kinase domain containing protein 0.0154 0.106 0.1151
Brugia malayi Protein kinase domain containing protein 0.0202 0.1547 0.168
Echinococcus granulosus calcium dependent protein kinase 0.0069 0.018 0.018
Echinococcus multilocularis Immunoglobulin 0.0072 0.022 0.0267
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0165 0.1168 0.1417
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.009 0.0396 0.043
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0145 0.0967 0.1174
Trichomonas vaginalis CAMK family protein kinase 0.0272 0.2265 0.9302
Echinococcus multilocularis serine:threonine protein kinase 0.0115 0.0651 0.0791
Onchocerca volvulus 0.0129 0.0802 0.2371
Echinococcus granulosus expressed protein 0.0083 0.0331 0.0331
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0507 0.1994
Schistosoma mansoni serine/threonine protein kinase 0.0355 0.3115 0.5371
Trichomonas vaginalis AGC family protein kinase 0.0289 0.2433 1
Echinococcus granulosus epidermal growth factor receptor 0.0407 0.3649 0.3649
Brugia malayi Kinase associated domain 1 family protein 0.0103 0.0531 0.0577
Echinococcus granulosus tyrosine protein kinase Src42A 0.0112 0.0627 0.0627
Brugia malayi Protein kinase domain containing protein 0.037 0.3262 0.3543
Echinococcus granulosus tyrosine protein kinase 0.0289 0.2439 0.2439
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0101 0.0514 0.4076
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0086 0.0361 0.0438
Echinococcus multilocularis 0.0175 0.1273 0.1545
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.1768 0.3049
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0437 0.3956 0.4802
Trypanosoma brucei SNF1-related protein kinases, putative 0.009 0.0396 0.0468
Entamoeba histolytica protein kinase, putative 0.0064 0.0137 0.0402
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0113 0.064 0.1611
Brugia malayi Pleckstrin Homology Domain 0.0051 0.0003 0.0003
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0187 0.1392 0.169
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.1445 0.1754
Entamoeba histolytica protein kinase, putative 0.0146 0.0975 0.2864
Echinococcus granulosus twitchin 0.0124 0.0747 0.0747
Schistosoma mansoni tyrosine kinase 0.036 0.3166 0.5458
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0076 0.0261 0.1005
Entamoeba histolytica protein kinase, putative 0.0086 0.0361 0.106
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0101 0.0514 0.0624
Brugia malayi Tyrosine-protein kinase abl-1 0.0133 0.0839 0.0912
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0146 0.0969 0.0969
Brugia malayi Cam kinase protein 1 0.0101 0.0514 0.0558
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0402 0.3596 0.3596
Onchocerca volvulus 0.0144 0.0954 0.2822
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0514 0.0886
Brugia malayi SRC-1 0.0192 0.1445 0.157
Echinococcus multilocularis ephrin type A receptor 4 A 0.0112 0.0623 0.0756
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0116 0.0661 0.0661
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1063 0.1832
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.0865 0.1492
Brugia malayi Immunoglobulin I-set domain containing protein 0.0266 0.2204 0.2394
Plasmodium vivax casein kinase 1, putative 0.0109 0.0595 0.4906
Schistosoma mansoni tyrosine kinase 0.0454 0.412 0.7104
Onchocerca volvulus 0.0098 0.0483 0.1429
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0119 0.07 0.07
Trichomonas vaginalis CMGC family protein kinase 0.014 0.0908 0.3663
Loa Loa (eye worm) TK/EGFR protein kinase 0.0618 0.58 0.6301
Echinococcus granulosus mitogen activated protein kinase 11 0.016 0.1116 0.1116
Echinococcus granulosus casein kinase I gamma 0.0154 0.1055 0.1055
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0355 0.3115 0.3115
Trypanosoma brucei aurora B kinase 0.0146 0.0975 0.318
Leishmania major protein kinase A catalytic subunit isoform 1 0.0113 0.064 0.1748
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0155 0.1063 0.1063
Trichomonas vaginalis CK1 family protein kinase 0.0109 0.0595 0.2361
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0113 0.064 0.064
Brugia malayi probable protein kinase 0.0267 0.2209 0.24
Schistosoma mansoni tyrosine kinase 0.037 0.326 0.5621
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0146 0.0975 0.8817
Echinococcus multilocularis casein kinase I alpha 0.0109 0.0595 0.0722
Onchocerca volvulus 0.009 0.04 0.1182
Giardia lamblia Kinase, STE STE20 0.0085 0.0347 0.0083
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0113 0.0633 0.0769
Brugia malayi protein kinase C3,putative 0.0159 0.1101 0.1197
Echinococcus multilocularis protein kinase c iota type 0.0281 0.2351 0.2854
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0396 0.0683
Giardia lamblia Kinase, CMGC CLK 0.0154 0.106 0.3769
Trichomonas vaginalis CK1 family protein kinase 0.0109 0.0595 0.2361
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0194 0.1464 0.1591
Brugia malayi Furin-like cysteine rich region family protein 0.0618 0.58 0.6301
Brugia malayi serine/threonine-protein kinase plk-2 0.0272 0.2265 0.246
Loa Loa (eye worm) CDC7 protein kinase 0.009 0.04 0.0434
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0113 0.064 0.4331
Echinococcus multilocularis expressed protein 0.0083 0.0331 0.0402
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0247 0.201 0.244
Echinococcus multilocularis tyrosine protein kinase Srms 0.0157 0.1089 0.1322
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0155 0.1063 0.1154
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0072 0.022 0.0267
Echinococcus multilocularis casein kinase I delta 0.0109 0.0595 0.0722
Plasmodium falciparum serine/threonine protein kinase 0.0083 0.0331 0.044
Echinococcus granulosus casein kinase ii subunit alpha 0.01 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0113 0.0633 0.0688
Echinococcus multilocularis epidermal growth factor receptor 0.0618 0.58 0.704
Onchocerca volvulus 0.0098 0.0483 0.1429
Trypanosoma cruzi cdc2-related kinase 3 0.0119 0.07 0.2975
Onchocerca volvulus 0.014 0.0913 0.2699
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0237 0.1902 0.2309
Plasmodium falciparum casein kinase 2, alpha subunit 0.01 0.0507 0.2652
Brugia malayi Protein kinase domain containing protein 0.0195 0.1474 0.1601
Brugia malayi hypothetical protein 0.0224 0.1768 0.1921
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0155 0.1063 0.129
Echinococcus granulosus Protein kinase C brain isozyme 0.0238 0.1917 0.1917
Schistosoma mansoni hypothetical protein 0.0113 0.0633 0.1092
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0154 0.106 0.1151
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0192 0.1445 0.1754
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.016 0.1116 0.4167
Schistosoma mansoni serine/threonine protein kinase 0.0187 0.1392 0.24
Giardia lamblia Kinase, CMGC GSK 0.0129 0.0802 0.2435
Schistosoma mansoni hypothetical protein 0.0103 0.0531 0.0916
Schistosoma mansoni tyrosine kinase 0.0079 0.0286 0.0493
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0101 0.0514 0.0558
Schistosoma mansoni serine/threonine protein kinase 0.0286 0.2402 0.4142
Echinococcus granulosus nervana 2 0.0125 0.0756 0.0756
Echinococcus granulosus cyclin dependent kinase 0.0119 0.07 0.07
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0259 0.2126 0.2309
Echinococcus multilocularis 0.0122 0.0726 0.0881
Echinococcus multilocularis cyclin dependent kinase 19 0.0165 0.1168 0.1417
Loa Loa (eye worm) TK/FER protein kinase 0.0098 0.0483 0.0525
Schistosoma mansoni protein kinase 0.0437 0.3956 0.682
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Loa Loa (eye worm) TK/FER protein kinase 0.0098 0.0483 0.0525
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0129 0.0802 0.0871
Entamoeba histolytica protein kinase, putative 0.0084 0.0334 0.0981
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0154 0.1055 0.1146
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0081 0.0306 0.0371
Echinococcus granulosus tyrosine protein kinase Src64B 0.0192 0.1445 0.1445
Echinococcus multilocularis serine:threonine protein kinase 0.0115 0.0651 0.0791
Onchocerca volvulus 0.0098 0.0483 0.1429
Schistosoma mansoni protein kinase 0.0237 0.1902 0.328
Onchocerca volvulus 0.0186 0.1387 0.41
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0499 0.458 0.458
Brugia malayi cell division control protein 2 homolog 0.0119 0.07 0.076
Trichomonas vaginalis AGC family protein kinase 0.0082 0.0314 0.1194
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0133 0.0839 0.1447
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0083 0.0331 0.0171
Echinococcus granulosus mitogen activated protein kinase 14 0.016 0.1116 0.1116
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.024 0.1932 0.2345
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0314 0.0541
Brugia malayi hypothetical protein 0.0088 0.0382 0.0414
Loa Loa (eye worm) hypothetical protein 0.0087 0.0369 0.0401
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0055 0.0037 0.004
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0192 0.1445 0.1754
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0086 0.0361 0.0361
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0081 0.0306 0.0306
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0237 0.1902 0.1902
Schistosoma mansoni atypical protein kinase C 0.0287 0.2414 0.4162
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0146 0.0975 0.2864
Echinococcus granulosus aurora kinase A 0.0146 0.0975 0.0975
Echinococcus granulosus calcium activated potassium channel 0.0136 0.0865 0.0865
Entamoeba histolytica protein kinase domain containing protein 0.0204 0.1566 0.4598
Echinococcus multilocularis mitogen activated protein kinase 14 0.016 0.1116 0.1355
Loa Loa (eye worm) hypothetical protein 0.0122 0.0726 0.0788
Trichomonas vaginalis AGC family protein kinase 0.0289 0.2433 1
Echinococcus granulosus cyclin dependent kinase 19 0.0165 0.1168 0.1168
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.0337 0.1291
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.0204 0.0352
Brugia malayi Serine/threonine-protein kinase SULU 0.0224 0.1768 0.1921
Brugia malayi Variant SH3 domain containing protein 0.0093 0.0432 0.0469
Entamoeba histolytica protein kinase domain containing protein 0.0129 0.0802 0.2354
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0093 0.0432 0.0525
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0165 0.1168 0.1168
Schistosoma mansoni kinase 0.0291 0.2455 0.4233
Loa Loa (eye worm) AGC/NDR protein kinase 0.0155 0.1063 0.1154
Echinococcus multilocularis nervana 2 0.0125 0.0756 0.0918
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.07 0.2797
Loa Loa (eye worm) TK/FER protein kinase 0.0404 0.3618 0.393
Entamoeba histolytica protein kinase domain containing protein 0.0123 0.0735 0.2159
Toxoplasma gondii AGC kinase 0.028 0.234 1
Echinococcus granulosus casein kinase i 0.0109 0.0595 0.0595
Echinococcus multilocularis serine:threonine protein kinase 3 0.0259 0.2126 0.2581
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.016 0.1116 0.4845
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0125 0.0756 0.0918
Loa Loa (eye worm) AGC/PKG protein kinase 0.0135 0.0863 0.0937
Echinococcus multilocularis mitogen activated protein kinase 3 0.0084 0.0337 0.0409
Plasmodium falciparum calcium-dependent protein kinase 5 0.0101 0.0514 0.2747
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0802 0.3221
Loa Loa (eye worm) TK/ALK protein kinase 0.0286 0.2405 0.2613
Loa Loa (eye worm) hypothetical protein 0.0106 0.0563 0.0611
Onchocerca volvulus 0.0098 0.0483 0.1429
Plasmodium vivax serine/threonine kinase-1, putative 0.0154 0.106 0.9683
Schistosoma mansoni titin 0.0067 0.0168 0.0289
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.024 0.1932 0.2098
Toxoplasma gondii CMGC kinase, CK2 family 0.01 0.0507 0.1031
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0113 0.064 0.064
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.064 0.1103
Leishmania major protein kinase, putative 0.0154 0.106 0.3879
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.0863 0.1488
Brugia malayi Fes/CIP4 homology domain containing protein 0.0111 0.0619 0.0672
Echinococcus granulosus myotubularin protein 13 0.0051 0.0003 0.0003
Echinococcus multilocularis neuroglian 0.0091 0.0413 0.0501
Brugia malayi casein kinase I 0.0109 0.0595 0.0646
Onchocerca volvulus 0.009 0.04 0.1182
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0084 0.0337 0.1349
Brugia malayi Temporarily assigned gene name protein 59 0.0113 0.0633 0.0688
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0119 0.07 0.2051
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0113 0.0633 0.2677
Schistosoma mansoni protein kinase 0.0194 0.1464 0.2525
Brugia malayi Protein kinase domain containing protein 0.0165 0.1168 0.1268
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0219 0.1721 0.1869
Schistosoma mansoni protein kinase 0.0267 0.2209 0.3809
Schistosoma mansoni serine/threonine protein kinase 0.014 0.0908 0.1566
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0507 0.1994
Loa Loa (eye worm) hypothetical protein 0.0088 0.0382 0.0414
Loa Loa (eye worm) hypothetical protein 0.009 0.0396 0.043
Brugia malayi RhoGAP domain containing protein 0.0093 0.0432 0.0469
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Echinococcus multilocularis calcium activated potassium channel 0.0136 0.0865 0.1051
Brugia malayi Immunoglobulin I-set domain containing protein 0.0088 0.0382 0.0414
Echinococcus multilocularis death associated protein kinase 1 0.0856 0.8238 1
Trichomonas vaginalis AGC family protein kinase 0.0289 0.2433 1
Loa Loa (eye worm) AUR protein kinase 0.0146 0.0975 0.106
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0168 0.0289
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0396 0.0683
Echinococcus multilocularis casein kinase I delta 0.0109 0.0595 0.0722
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0037 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0289 0.2433 1
Schistosoma mansoni tyrosine kinase 0.0407 0.3649 0.6291
Echinococcus granulosus insulin receptor 0.0454 0.412 0.412
Entamoeba histolytica protein kinase 2, putative 0.0158 0.1091 0.3202
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0113 0.064 0.0777
Brugia malayi Protein kinase domain containing protein 0.0155 0.1063 0.1154
Schistosoma mansoni tyrosine kinase 0.0558 0.5192 0.8951
Brugia malayi Protein kinase domain containing protein 0.0119 0.07 0.076
Loa Loa (eye worm) hypothetical protein 0.0113 0.064 0.0695
Brugia malayi casein kinase 1, delta 0.0109 0.0595 0.0646
Schistosoma mansoni ephrin receptor 0.0063 0.0123 0.0213
Brugia malayi C1-like domain containing protein 0.0219 0.1721 0.1869
Trichomonas vaginalis CAMK family protein kinase 0.0218 0.1714 0.7013
Brugia malayi Protein kinase domain containing protein 0.009 0.04 0.0434
Loa Loa (eye worm) hypothetical protein 0.0113 0.0633 0.0688
Toxoplasma gondii casein kinase I 0.0109 0.0595 0.1463
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0118 0.0682 0.0741
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0247 0.201 0.201
Loa Loa (eye worm) hypothetical protein 0.0113 0.0633 0.0688
Onchocerca volvulus 0.0076 0.0261 0.0771
Entamoeba histolytica cell division protein kinase 2, putative 0.0119 0.07 0.2054
Trypanosoma brucei protein kinase, putative 0.0129 0.0802 0.2367
Brugia malayi Protein kinase domain containing protein 0.0155 0.1063 0.1154
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0093 0.0432 0.0745
Toxoplasma gondii AGC kinase 0.0113 0.064 0.1683
Schistosoma mansoni serine/threonine-protein kinase 0.0167 0.1183 0.2039
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0082 0.0314 0.0341
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0119 0.07 0.1975
Echinococcus multilocularis growth factor receptor bound protein 2 0.0086 0.0356 0.0432
Leishmania major protein kinase, putative 0.0154 0.106 0.3879
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0085 0.0347 0.1392
Schistosoma mansoni cell adhesion molecule 0.0103 0.0531 0.0916
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0101 0.0514 0.4076
Plasmodium vivax calcium-dependent protein kinase, putative 0.0101 0.0514 0.4076
Schistosoma mansoni serine/threonine protein kinase 0.0237 0.19 0.3276
Schistosoma mansoni tyrosine kinase 0.0192 0.1445 0.2491
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0101 0.0514 0.1022
Brugia malayi SH2 domain containing protein 0.0098 0.0483 0.0525
Echinococcus multilocularis nervana 2 0.0125 0.0756 0.0918
Echinococcus granulosus protein kinase shaggy 0.0129 0.0802 0.0802
Schistosoma mansoni growth factor receptor-bound protein 0.0086 0.0356 0.0614
Entamoeba histolytica protein kinase, putative 0.0102 0.0527 0.1548
Entamoeba histolytica protein kinase, putative 0.0146 0.0975 0.2864
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0113 0.064 0.1683
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0113 0.064 0.2707
Echinococcus granulosus tyrosine kinase 0.0157 0.1089 0.1089
Schistosoma mansoni rap gtpase-activating protein 0.0113 0.0633 0.1092
Echinococcus multilocularis casein kinase I gamma 0.0154 0.1055 0.128
Echinococcus multilocularis mitogen activated protein kinase 11 0.016 0.1116 0.1355
Loa Loa (eye worm) hypothetical protein 0.0073 0.0223 0.0242
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0113 0.064 0.537
Loa Loa (eye worm) hypothetical protein 0.0144 0.0954 0.1037
Echinococcus granulosus neuroglian 0.0091 0.0413 0.0413
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0154 0.106 0.4591
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0113 0.0633 0.0633
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0192 0.1445 0.1754
Echinococcus granulosus serine:threonine protein kinase 0.0115 0.0651 0.0651
Plasmodium falciparum serine/threonine protein kinase, putative 0.0146 0.0975 0.8551
Brugia malayi Protein kinase domain containing protein 0.0289 0.2433 0.2643
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0055 0.0037 0.004
Schistosoma mansoni protein kinase 0.0109 0.0595 0.1026
Onchocerca volvulus 0.0098 0.0483 0.1429
Echinococcus multilocularis c src tyrosine kinase 0.0133 0.0839 0.1019
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0154 0.106 0.3736
Echinococcus granulosus N chimaerin 0.0093 0.0432 0.0432
Echinococcus granulosus Glutaredoxin protein 5 0.0125 0.0756 0.0756
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.014 0.0908 0.0987
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0086 0.0361 0.0438
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0129 0.0802 0.0802
Echinococcus granulosus cGMP dependent protein kinase 1 0.0135 0.0863 0.0863
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0157 0.1089 0.1089
Brugia malayi Protein kinase c protein 2 0.0116 0.0668 0.0725
Giardia lamblia Kinase, CAMK CAMKL 0.009 0.0396 0.0337
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.01 0.0507 0.3998
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0396 0.1534
Brugia malayi Protein kinase domain containing protein 0.0286 0.2406 0.2614
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0086 0.0361 0.0361
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0072 0.022 0.0379
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0086 0.0361 0.0438
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0109 0.0595 0.0646
Entamoeba histolytica protein kinase, putative 0.0071 0.0204 0.0599
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0101 0.0514 0.0514
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0085 0.0347 0.1392
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0129 0.0802 0.0973
Brugia malayi Protein kinase domain containing protein 0.0082 0.0314 0.0341
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0187 0.1392 0.1512
Brugia malayi SH2 domain containing protein 0.0404 0.3618 0.393
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0165 0.1168 0.1268
Echinococcus multilocularis N chimaerin 0.0093 0.0432 0.0525
Trichomonas vaginalis CK1 family protein kinase 0.0109 0.0595 0.2361
Echinococcus multilocularis myotubularin protein 13 0.0051 0.0003 0.0004
Trichomonas vaginalis STE family protein kinase 0.0064 0.0137 0.0457
Echinococcus multilocularis mitogen activated protein kinase 14 0.016 0.1116 0.1355
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.014 0.0908 0.2995
Entamoeba histolytica PH domain containing protein kinase, putative 0.0167 0.1183 0.3473
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0157 0.1089 0.1322
Schistosoma mansoni hypothetical protein 0.0103 0.0531 0.0916
Loa Loa (eye worm) hypothetical protein 0.0182 0.1345 0.1461
Loa Loa (eye worm) TK/FER protein kinase 0.0098 0.0483 0.0525
Giardia lamblia Aurora kinase 0.0146 0.0975 0.3333
Schistosoma mansoni tyrosine kinase 0.0133 0.0839 0.1447
Echinococcus granulosus tyrosine protein kinase Fyn 0.0192 0.1445 0.1445
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0071 0.0204 0.0204
Echinococcus granulosus dual specificity 0.014 0.0908 0.0908
Giardia lamblia Kinase, CAMK CAMKL 0.009 0.0396 0.0337
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.1704 0.2938
Trypanosoma brucei Casein kinase II 0.01 0.0507 0.0986
Echinococcus granulosus casein kinase I alpha 0.0109 0.0595 0.0595
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.064 0.1103
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0135 0.0863 0.1047
Loa Loa (eye worm) TK/KIN16 protein kinase 0.045 0.4079 0.4431
Echinococcus multilocularis serine:threonine kinase SAD 1 0.009 0.0396 0.0481
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0123 0.0735 0.3135
Schistosoma mansoni serine/threonine protein kinase 0.0123 0.0735 0.1268
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0113 0.064 0.0695
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0101 0.0514 0.0514
Trichomonas vaginalis CMGC family protein kinase 0.01 0.0507 0.1994
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.0331 0.057
Onchocerca volvulus 0.0113 0.0633 0.1872
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.1055 0.1818
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.014 0.0908 0.3911
Echinococcus granulosus mitogen activated protein kinase 0.0084 0.0337 0.0337
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0119 0.07 0.076
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0085 0.0347 0.1018
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.106 0.1827
Loa Loa (eye worm) hypothetical protein 0.0115 0.0651 0.0707
Trichomonas vaginalis STE family protein kinase 0.0137 0.0879 0.3542
Giardia lamblia Kinase, CMGC MAPK 0.0084 0.0337 0.0034
Brugia malayi STE20-like kinase MST 0.0259 0.2126 0.2309
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.009 0.0396 0.0508
Echinococcus multilocularis casein kinase i 0.0109 0.0595 0.0722
Brugia malayi Protein kinase domain containing protein 0.0154 0.1055 0.1146
Entamoeba histolytica protein kinase domain containing protein 0.01 0.0507 0.1487
Schistosoma mansoni tyrosine kinase 0.0407 0.3649 0.6291
Trichomonas vaginalis AGC family protein kinase 0.0113 0.064 0.2549
Giardia lamblia Kinase, AGC PKA 0.0113 0.064 0.1599
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0087 0.0369 0.0369
Brugia malayi Hr1 repeat family protein 0.0286 0.2402 0.261
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0083 0.0331 0.0178
Echinococcus granulosus cGMP dependent protein kinase 0.0135 0.0863 0.0863
Brugia malayi Protein kinase domain containing protein 0.0605 0.5672 0.6162
Schistosoma mansoni tyrosine kinase 0.0314 0.2689 0.4637
Echinococcus granulosus tyrosine protein kinase Src42A 0.0192 0.1445 0.1445
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0165 0.1164 0.1265
Trichomonas vaginalis CAMK family protein kinase 0.0272 0.2265 0.9302
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0202 0.1547 0.168
Echinococcus granulosus serine:threonine kinase SAD 1 0.009 0.0396 0.0396
Schistosoma mansoni protein kinase 0.0154 0.1055 0.1818
Toxoplasma gondii histone kinase SNF1, putative 0.009 0.0396 0.0489
Schistosoma mansoni protein kinase 0.008 0.0296 0.051
Echinococcus multilocularis serine:threonine protein kinase 38 0.0155 0.1063 0.129
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0469 0.4282 0.4282
Trichomonas vaginalis CAMK family protein kinase 0.0272 0.2265 0.9302
Echinococcus multilocularis cyclin dependent kinase 0.0119 0.07 0.0849
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0146 0.0975 0.1184
Echinococcus multilocularis aurora kinase A 0.0146 0.0975 0.1184
Echinococcus multilocularis casein kinase ii subunit alpha 0.01 0.0507 0.0615
Plasmodium falciparum serine/threonine protein kinase KIN 0.009 0.0396 0.1259
Mycobacterium ulcerans hypothetical protein 0.0103 0.0529 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0642 0.1106
Schistosoma mansoni tyrosine kinase 0.036 0.3166 0.5458
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0296 0.0869
Loa Loa (eye worm) hypothetical protein 0.014 0.0913 0.0991
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0152 0.1031 0.112
Plasmodium vivax protein kinase Crk2 0.0119 0.07 0.5983
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0113 0.064 0.0777
Echinococcus granulosus protein kinase 0.0154 0.1055 0.1055
Trichomonas vaginalis AGC family protein kinase 0.0146 0.0975 0.3943
Trichomonas vaginalis STE family protein kinase 0.0086 0.0361 0.1389
Loa Loa (eye worm) hypothetical protein 0.0242 0.1956 0.2125
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0086 0.0356 0.0387
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0067 0.0168 0.0182
Trypanosoma cruzi cdc2-related kinase 1 0.0119 0.07 0.2975
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0237 0.19 0.2307
Echinococcus granulosus serine:threonine protein kinase 3 0.0259 0.2126 0.2126
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0155 0.1063 0.129
Schistosoma mansoni vesicular amine transporter 0.0072 0.022 0.0379
Giardia lamblia Kinase, NEK 0.0137 0.0879 0.2834
Brugia malayi Protein kinase domain containing protein 0.0218 0.1714 0.1862
Echinococcus granulosus serine/threonine protein kinase 0.0167 0.1183 0.1183
Brugia malayi Protein kinase domain containing protein 0.0098 0.0483 0.0525
Trichomonas vaginalis CAMK family protein kinase 0.0127 0.0778 0.3122
Entamoeba histolytica protein kinase , putative 0.0146 0.0975 0.2864
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.014 0.0908 0.2865
Trichomonas vaginalis STE family protein kinase 0.0085 0.0347 0.133
Giardia lamblia Kinase, CMGC CDK 0.0119 0.07 0.1907
Loa Loa (eye worm) hypothetical protein 0.0234 0.1875 0.2037
Trichomonas vaginalis CMGC family protein kinase 0.0129 0.0802 0.3221
Echinococcus granulosus raf serine:threonine protein kinase 0.0089 0.0394 0.0394
Echinococcus granulosus NDR protein kinase 0.0155 0.1063 0.1063
Trypanosoma cruzi casein kinase II, putative 0.01 0.0507 0.2109
Schistosoma mansoni tyrosine kinase 0.0133 0.0839 0.1447
Trypanosoma cruzi polo-like protein kinase, putative 0.0272 0.2265 1
Onchocerca volvulus 0.0195 0.1479 0.4373
Loa Loa (eye worm) gastrulation defective protein 1 0.0132 0.0833 0.0905
Loa Loa (eye worm) TK/FER protein kinase 0.0098 0.0483 0.0525
Plasmodium falciparum calcium-dependent protein kinase 2 0.0101 0.0514 0.2747
Schistosoma mansoni serine/threonine protein kinase 0.0272 0.2265 0.3905

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.3582 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.