Detailed information for compound 1363156

Basic information

Technical information
  • TDR Targets ID: 1363156
  • Name: 5-[(cyclopropylamino)methylidene]-1-(2-methox yphenyl)-1,3-diazinane-2,4,6-trione
  • MW: 301.297 | Formula: C15H15N3O4
  • H donors: 2 H acceptors: 3 LogP: 1.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1C(=O)NC(=O)/C(=C\NC2CC2)/C1=O
  • InChi: 1S/C15H15N3O4/c1-22-12-5-3-2-4-11(12)18-14(20)10(8-16-9-6-7-9)13(19)17-15(18)21/h2-5,8-9,16H,6-7H2,1H3,(H,17,19,21)/b10-8+
  • InChiKey: UZDKUBZRQGELKU-CSKARUKUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5E)-5-[(cyclopropylamino)methylidene]-1-(2-methoxyphenyl)-1,3-diazinane-2,4,6-trione
  • 5-[(cyclopropylamino)methylene]-1-(2-methoxyphenyl)hexahydropyrimidine-2,4,6-trione
  • (5E)-5-[(cyclopropylamino)methylene]-1-(2-methoxyphenyl)hexahydropyrimidine-2,4,6-trione
  • 5-[(cyclopropylamino)methylene]-1-(2-methoxyphenyl)barbituric acid
  • (5E)-5-[(cyclopropylamino)methylene]-1-(2-methoxyphenyl)barbituric acid
  • 5-[1-Cyclopropylamino-meth-(E)-ylidene]-1-(2-methoxy-phenyl)-pyrimidine-2,4,6-trione
  • MLS000557390
  • SMR000148307
  • STOCK3S-96405

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dnaJ subfamily B 0.0679 0.6775 0.6775
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0124 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0141 0.0143
Brugia malayi MH2 domain containing protein 0.0019 0.0078 0.0101
Leishmania major cysteine peptidase A (CPA) 0.0044 0.0337 0.2041
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0124 0.0124
Entamoeba histolytica cysteine proteinase, putative 0.0044 0.0337 0.2501
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0014 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0337 0.0365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0337 0.0365
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0023 0.012 0.0668
Plasmodium vivax JmjC domain containing protein 0.0015 0.0044 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0189 0.0197
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0031 0.0031
Echinococcus multilocularis cathepsin L 0.0023 0.012 0.012
Leishmania major trypanothione reductase 0.0046 0.0352 0.2136
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0946 0.3391
Mycobacterium ulcerans lipase LipD 0.0043 0.033 0.273
Brugia malayi ecdysteroid receptor 0.0023 0.0124 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.017 0.0176
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0017
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.033 0.273
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0298 0.2906 1
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0388 0.0388
Brugia malayi Cathepsin L-like precursor 0.0044 0.0337 0.0433
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0044 0.0336 0.2033
Plasmodium vivax hypothetical protein, conserved 0.0043 0.033 0.102
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0946 0.8876
Schistosoma mansoni zinc finger protein 0.0106 0.0962 0.142
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.138 0.1772
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.005 0.0122
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.005 0.025
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.1096 0.3954
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0124 0.0183
Trypanosoma cruzi cysteine proteinase, putative 0.0023 0.012 0.0668
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0106 0.0962 0.0962
Chlamydia trachomatis DNA topoisomerase I 0.0298 0.2906 1
Brugia malayi MH1 domain containing protein 0.0019 0.0078 0.0101
Toxoplasma gondii target of rapamycin (TOR), putative 0.0098 0.088 0.2926
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0337 0.0365
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0116 0.0116
Loa Loa (eye worm) brahma associated protein 0.0298 0.2906 0.3732
Onchocerca volvulus 0.0043 0.033 0.0372
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0064 0.0343
Loa Loa (eye worm) hypothetical protein 0.0459 0.4542 0.5833
Brugia malayi Pre-SET motif family protein 0.0779 0.7787 1
Echinococcus granulosus cathepsin l1 0.0044 0.0337 0.0337
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0946 0.3391
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0113 0.0145
Brugia malayi beta-lactamase 0.0043 0.033 0.0424
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0028 0.0169 0.025
Schistosoma mansoni hypothetical protein 0.0267 0.2596 0.3832
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0336 0.0431
Onchocerca volvulus 0.0106 0.0962 0.1084
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0124 0.0183
Schistosoma mansoni hypothetical protein 0.0145 0.1361 0.2009
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0038 0.0276 0.0816
Echinococcus granulosus survival motor neuron protein 1 0.0371 0.3647 0.3647
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.005 0.0203
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.005 0.0043
Loa Loa (eye worm) runx1 0.0054 0.0439 0.0564
Leishmania major hypothetical protein, conserved 0.0043 0.033 0.1994
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0064 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0064 0.0343
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0087 0.0087
Brugia malayi steroid hormone receptor 0.0023 0.0124 0.016
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0131 0.1222 0.7636
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0608 0.067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0342 0.0505
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.013 0.1205 0.1205
Plasmodium falciparum histone acetyltransferase GCN5 0.0035 0.0244 0.0703
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0033 0.0221 0.1968
Brugia malayi jmjC domain containing protein 0.0015 0.0044 0.0057
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0124 0.0124
Entamoeba histolytica cysteine protease, putative 0.0023 0.012 0.0658
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0105 0.095 0.5914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0609 0.0671
Schistosoma mansoni hypothetical protein 0.0314 0.307 0.4531
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0106 0.0962 0.599
Brugia malayi Probable ClpP-like protease 0.005 0.0395 0.0507
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.005 0.0223
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0042 0.0042
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0388 0.2382
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0779 0.7787 1
Brugia malayi jmjC domain containing protein 0.0015 0.0044 0.0057
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0139 0.0354
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0007 0.0009
Schistosoma mansoni cpg binding protein 0.0078 0.0677 0.0999
Brugia malayi Cathepsin L-like precursor 0.0044 0.0337 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0058 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0064 0.0343
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.033 0.0356
Echinococcus granulosus GPCR family 2 0.0145 0.1361 0.1361
Echinococcus granulosus zinc finger protein Ran binding 0.0106 0.0962 0.0962
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0044 0.0065
Echinococcus granulosus Zinc finger RanBP2 type 0.0106 0.0962 0.0962
Trichomonas vaginalis ferritin, putative 0.0017 0.0062 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1597 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.005 0.0395 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0337 0.0365
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.033 0.0356
Schistosoma mansoni ferritin 0.0017 0.0062 0.0092
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.005 0.0025
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0042 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0337 0.0365
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.033 0.0487
Echinococcus granulosus smad 0.0019 0.0078 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0336 0.0363
Loa Loa (eye worm) Smad1 0.0019 0.0078 0.0101
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0064 0.0316
Trypanosoma cruzi cysteine protease, putative 0.0023 0.012 0.0668
Toxoplasma gondii histone lysine methyltransferase SET1 0.0147 0.1376 0.4655
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0124 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.012 0.0119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0337 0.0365
Loa Loa (eye worm) hypothetical protein 0.0105 0.0957 0.1229
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0337 0.0365
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.012 0.0154
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0025 0.0141 0.0141
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0044 0.0336 0.2033
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0106 0.0962 0.599
Brugia malayi beta-lactamase family protein 0.0043 0.033 0.0424
Brugia malayi YY1-associated factor 2 0.0106 0.0962 0.1236
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0116 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0064 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0783 0.0868
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0124 0.016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0223
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0019 0.0029
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0028 0.0169 0.1078
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0124 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0337 0.0365
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0031 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0337 0.0365
Schistosoma mansoni hypothetical protein 0.0145 0.1361 0.2009
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0603 0.0603
Treponema pallidum NADH oxidase 0.0016 0.005 0.0203
Brugia malayi Cathepsin L-like precursor 0.0044 0.0337 0.0433
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0064 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0609 0.0671
Schistosoma mansoni mixed-lineage leukemia protein mll 0.016 0.1512 0.2232
Echinococcus granulosus dna polymerase eta 0.0017 0.0064 0.0064
Entamoeba histolytica cysteine protease, putative 0.0023 0.012 0.0658
Brugia malayi Cathepsin L-like precursor 0.0044 0.0337 0.0433
Loa Loa (eye worm) hypothetical protein 0.0027 0.0161 0.0206
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0298 0.2906 0.2906
Trypanosoma cruzi target of rapamycin kinase 3 0.0105 0.095 0.5914
Schistosoma mansoni hypothetical protein 0.0145 0.1361 0.2009
Loa Loa (eye worm) beta-lactamase 0.0043 0.033 0.0424
Schistosoma mansoni smad1 5 8 and 0.0019 0.0078 0.0116
Entamoeba histolytica cysteine protease, putative 0.0023 0.012 0.0658
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0145 0.1361 0.1748
Schistosoma mansoni smad1 5 8 and 0.0019 0.0078 0.0116
Entamoeba histolytica hypothetical protein 0.007 0.0603 0.4756
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0223
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.1096 0.1617
Schistosoma mansoni single-minded 0.0048 0.0371 0.0547
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.005 0.0395 0.1232
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0042 0.0054
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0064 0.0083
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1096 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0019 0.0086 0.0086
Echinococcus granulosus histone lysine methyltransferase setb 0.0113 0.1036 0.1036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.088 0.0977
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0337 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0055 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0058 0.0049
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.016
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0246 0.0315
Toxoplasma gondii ABC1 family protein 0.0043 0.033 0.1004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.033 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0058 0.0049
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0124 0.0124
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1064 1
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0388 0.2929
Schistosoma mansoni cathepsin s 0.0015 0.0037 0.0055
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0124 0.0124
Echinococcus multilocularis cpg binding protein 0.0078 0.0677 0.0677
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.012 0.0658
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0189 0.0197
Loa Loa (eye worm) hypothetical protein 0.0025 0.0139 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0124 0.016
Entamoeba histolytica cysteine proteinase, putative 0.0044 0.0337 0.2501
Plasmodium vivax SET domain protein, putative 0.0113 0.1036 0.3481
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.6724 0.9924
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0058 0.0049
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0124 0.0124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0058 0.0049
Trypanosoma cruzi cysteine peptidase, putative 0.0168 0.1597 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0074 0.0635 0.0815
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0028 0.0169 0.0444
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1096 1
Brugia malayi Intermediate filament tail domain containing protein 0.004 0.0297 0.0381
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0124 0.0183
Schistosoma mansoni hypothetical protein 0.0679 0.6775 1
Leishmania major DNA polymerase eta, putative 0.0017 0.0064 0.0316
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0243
Brugia malayi acetyltransferase, GNAT family protein 0.013 0.1205 0.1548
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.016
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0131 0.1222 0.7636
Loa Loa (eye worm) hypothetical protein 0.0043 0.033 0.0424
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.005 0.0068
Schistosoma mansoni ferritin 0.0017 0.0062 0.0092
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0433 0.4276 0.5491
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0058 0.0049
Brugia malayi Cathepsin L-like precursor 0.0015 0.0037 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.012 0.0693
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0124 0.0183
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0342 0.0439
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0603 0.0603
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0223
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0019 0.0078 0.0078
Echinococcus granulosus cpg binding protein 0.0078 0.0677 0.0677
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0057
Schistosoma mansoni Smad4 0.0019 0.0078 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0023 0.012 0.0693
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0352 0.0452
Brugia malayi hypothetical protein 0.0433 0.4276 0.5491
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0019 0.0084 0.0084
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0078 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0048
Echinococcus multilocularis cysteine protease 0.0044 0.0337 0.0337
Entamoeba histolytica cysteine proteinase 1, putative 0.0023 0.012 0.0658
Loa Loa (eye worm) hypothetical protein 0.0176 0.1677 0.2154
Echinococcus multilocularis SWI:SNF matrix associated 0.0298 0.2906 0.2906
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1597 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.033 0.0487
Brugia malayi jmjC domain containing protein 0.0057 0.0472 0.0606
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0141 0.0827
Echinococcus granulosus cysteine protease 0.0023 0.012 0.012
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0139 0.0811
Trypanosoma brucei trypanothione reductase 0.0046 0.0352 0.2157
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0028 0.0169 0.0218
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0181
Loa Loa (eye worm) hypothetical protein 0.0106 0.0962 0.1236
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.016
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0124 0.0124
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.1096 0.3677
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.1677 0.1889
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0058 0.0049
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0044 0.0337 0.103
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0018
Mycobacterium ulcerans beta-lactamase 0.0043 0.033 0.273
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0298 0.2906 0.2906
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1597 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0086 0.011
Schistosoma mansoni hypothetical protein 0.0298 0.2906 0.429
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0062 0.0559
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.005 0.0395 0.0395
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0058 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0058 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.033 0.0356
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0139 0.0336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0949 0.1055
Echinococcus granulosus geminin 0.0267 0.2596 0.2596
Onchocerca volvulus 0.0035 0.0246 0.0277
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0013 0.0017
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.005 0.0043
Trichomonas vaginalis esterase, putative 0.0043 0.033 0.0356
Mycobacterium ulcerans hypothetical protein 0.0043 0.033 0.273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.088 0.0977
Loa Loa (eye worm) hypothetical protein 0.0044 0.0337 0.0433
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0124 0.0183
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0124 0.0124
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0064 0.0316
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0017 0.0063 0.0073
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.6724 0.6724
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0124 0.016
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0106 0.0962 0.3212
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.005 0.0395 0.335
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0131 0.1222 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0243
Entamoeba histolytica cysteine protease, putative 0.0023 0.012 0.0658
Brugia malayi cytoplasmic intermediate filament protein 0.0022 0.0107 0.0138
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0124 0.0124
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0042 0.0205
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0124 0.016
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0062 0.0559
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0044 0.0336 0.0336
Schistosoma mansoni survival motor neuron protein 0.0076 0.0656 0.0968
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0946 0.3391
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0298 0.2906 0.3732
Leishmania major hypothetical protein, conserved 0.0106 0.0962 0.599
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0337 0.0365
Plasmodium vivax hypothetical protein, conserved 0.0298 0.2906 1
Brugia malayi hypothetical protein 0.0159 0.1506 0.1933
Leishmania major hypothetical protein, conserved 0.0106 0.0962 0.599
Schistosoma mansoni ferritin light chain 0.0017 0.0062 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0962 0.599
Leishmania major hypothetical protein, conserved 0.0106 0.0962 0.599
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0247 0.0262
Echinococcus granulosus sodium channel protein 0.0032 0.0216 0.0216
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0044 0.0044
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0044 0.0057
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0044 0.0337 0.103
Schistosoma mansoni hypothetical protein 0.0298 0.2906 0.429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0608 0.067
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0025 0.0141 0.0837
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0113 0.1036 0.3469
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0044 0.0065
Loa Loa (eye worm) hypothetical protein 0.0043 0.033 0.0424
Toxoplasma gondii thioredoxin reductase 0.0046 0.0352 0.1082
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.005 0.0395 0.1317
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0514 0.0759
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0223
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0044 0.0057
Trichomonas vaginalis DNA polymerase eta, putative 0.0017 0.0064 0.0056
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0116 0.0171
Echinococcus granulosus expressed protein 0.0017 0.0062 0.0062
Brugia malayi Protein kinase domain containing protein 0.0014 0.0036 0.0046
Onchocerca volvulus 0.0074 0.0635 0.0715
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.005 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0336 0.0363
Onchocerca volvulus 0.0044 0.0337 0.038
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0013 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0141 0.0143
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.005 0.0395 0.1248
Loa Loa (eye worm) hypothetical protein 0.0043 0.033 0.0424
Brugia malayi Uncoordinated protein 44 0.0014 0.0031 0.004
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0223
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0603 0.089
Schistosoma mansoni DNA polymerase eta 0.0017 0.0064 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0962 0.599
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0064 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0124 0.016
Brugia malayi hypothetical protein 0.0016 0.005 0.0064
Onchocerca volvulus 0.0375 0.3695 0.4162
Plasmodium falciparum thioredoxin reductase 0.0046 0.0352 0.1082
Echinococcus granulosus Smad4 0.0019 0.0078 0.0078
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.033 0.108
Plasmodium falciparum cysteine proteinase falcipain 1 0.0023 0.012 0.0271
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0124 0.0183
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0946 0.3391
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1096 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.1096 0.6832
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0064 0.0082
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0044 0.0057
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0139 0.0786
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0618 0.0618
Leishmania major cathepsin L-like protease 0.0168 0.1597 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0145 0.1361 0.1748
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0124 0.0183
Brugia malayi glutathione reductase 0.0046 0.0352 0.0452
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0106 0.0962 0.6001
Brugia malayi SWIB/MDM2 domain containing protein 0.0298 0.2906 0.3732
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0013 0.0017
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0044 0.0044
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0044 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0124 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0609 0.0671
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.033 0.033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0124 0.016
Brugia malayi jmjC domain containing protein 0.0015 0.0044 0.0057
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.033 0.0424
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0141 0.0208
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0044 0.0044
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0028 0.017 0.0445
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0388 0.0422
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0388 0.0422
Loa Loa (eye worm) fibroinase 0.0044 0.0337 0.0433
Brugia malayi Cathepsin L-like precursor 0.0044 0.0337 0.0433
Leishmania major protein kinase, putative 0.0013 0.0019 0.0029
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0105 0.095 0.5925
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0031 0.0031
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0028 0.0169 0.0218
Plasmodium vivax vivapain-2 0.0044 0.0337 0.1046
Leishmania major cathepsin L-like protease 0.0168 0.1597 1
Onchocerca volvulus 0.0044 0.0337 0.038
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0044 0.0007
Echinococcus multilocularis peptidase Clp (S14 family) 0.0033 0.0221 0.0221
Echinococcus granulosus ferritin 0.0017 0.0062 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0124 0.016
Onchocerca volvulus 0.0044 0.0337 0.038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.1027 0.1143
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0016 0.0055 0.0258
Echinococcus granulosus peptidase Clp S14 family 0.0033 0.0221 0.0221
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0946 0.3391
Loa Loa (eye worm) hypothetical protein 0.0016 0.0055 0.0071
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0076 0.0656 0.0842
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.005 0.0223
Schistosoma mansoni apoferritin-2 0.0017 0.0062 0.0092
Brugia malayi Cathepsin L-like precursor 0.0044 0.0337 0.0433
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1064 0.3834
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0044 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0754 0.0835
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0044 0.0336 0.2055
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0472 0.0472
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0038 0.0276 0.0833
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.033 0.108
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0124 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0337 0.0365
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0044 0.0337 0.0337
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0031 0.004
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.005 0.0068
Schistosoma mansoni TRABID protein (C64 family) 0.0106 0.0962 0.142
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0019 0.0029
Entamoeba histolytica cysteine protease, putative 0.0023 0.012 0.0658
Schistosoma mansoni hypothetical protein 0.0011 0.0001 0.0001
Brugia malayi Smad1 0.0019 0.0078 0.0101
Schistosoma mansoni fusion 0.0106 0.0962 0.142
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0014 0.0014
Schistosoma mansoni peptidase Clp (S14 family) 0.005 0.0395 0.0583
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0106 0.0962 0.0962
Brugia malayi FAT domain containing protein 0.0019 0.0084 0.0108
Trichomonas vaginalis set domain proteins, putative 0.0886 0.8876 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0108
Echinococcus multilocularis dna polymerase eta 0.0017 0.0064 0.0064
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0064 0.0343
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0048
Brugia malayi hypothetical protein 0.007 0.0603 0.0775
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0106 0.0962 0.599
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0058 0.0049
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.012 0.0658
Schistosoma mansoni ferritin 0.0017 0.0062 0.0092
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0106 0.0962 0.599
Brugia malayi nuclear receptor NHR-88 0.0023 0.0124 0.016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0124 0.016
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.005 0.0223
Loa Loa (eye worm) hypothetical protein 0.0106 0.0962 0.1236
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0044 0.0337 0.0337
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0388 0.0422
Onchocerca volvulus 0.0146 0.1369 0.1542
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0058 0.0049
Loa Loa (eye worm) hypothetical protein 0.0019 0.0078 0.01
Echinococcus multilocularis dnaJ subfamily B 0.0679 0.6775 0.6775
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0337 0.0365
Entamoeba histolytica cysteine protease, putative 0.0023 0.012 0.0658
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.005 0.005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1597 1
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.005 0.004
Onchocerca volvulus 0.0106 0.0962 0.1084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0337 0.0365
Mycobacterium leprae conserved hypothetical protein 0.0043 0.033 0.3008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0124 0.016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0083
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0044 0.0044
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0141 0.0141
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0472 0.0696
Echinococcus multilocularis cysteine protease 0.0044 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0113 0.1036 0.133
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0042 0.0178
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0223
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0352 0.1098
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0064 0.0343
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0044 0.019
Brugia malayi cathepsin L-like precursor 0.003 0.0189 0.0243
Loa Loa (eye worm) hypothetical protein 0.0019 0.0078 0.01
Trypanosoma cruzi cysteine peptidase, putative 0.0168 0.1597 1
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0042 0.0032
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0124 0.0124
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0087 0.0087
Brugia malayi Papain family cysteine protease containing protein 0.0044 0.0337 0.0433
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0022 0.0107 0.0138
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0015 0.0037 0.0048
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0113 0.1036 0.1036
Plasmodium vivax unspecified product 0.0023 0.012 0.0288
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0106 0.0962 0.3212
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0057
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0161 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.0962 0.599
Toxoplasma gondii hypothetical protein 0.0017 0.0063 0.0073
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0124 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0124 0.016
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0044 0.0044
Onchocerca volvulus 0.0076 0.0656 0.0738
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.012 0.0177
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.005 0.0223
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0032 0.0216 0.0216
Onchocerca volvulus 0.0044 0.0337 0.038
Brugia malayi hypoxia-induced factor 1 0.0147 0.138 0.1772
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.0078 0.0116
Schistosoma mansoni cellular tumor antigen P53 0.0146 0.1369 0.202
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0124 0.016
Echinococcus multilocularis SWI:SNF matrix associated 0.0298 0.2906 0.2906
Echinococcus multilocularis lamin dm0 0.004 0.0297 0.0297
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0038 0.0055
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0459 0.4542 0.5833
Loa Loa (eye worm) hypothetical protein 0.0106 0.0962 0.1236
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0064 0.0343
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0033 0.0048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0042 0.0178
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0028 0.0169 0.0981
Loa Loa (eye worm) hypothetical protein 0.0106 0.0962 0.1236
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0161 0.0161
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0298 0.2906 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0044 0.0217
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0064 0.0208
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0028 0.0169 0.1006
Leishmania major hypothetical protein, conserved 0.0106 0.0962 0.599
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0044 0.0337 0.0433
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0064 0.0343
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0388 0.2361
Schistosoma mansoni lozenge 0.0054 0.0439 0.0648
Onchocerca volvulus 0.0106 0.0962 0.1084
Schistosoma mansoni hypothetical protein 0.0298 0.2906 0.429
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0037 0.0048
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0145 0.1361 0.1361
Loa Loa (eye worm) hypothetical protein 0.0028 0.017 0.0218
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0033 0.0221 0.067
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0028 0.0169 0.0444
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.033 0.033
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0298 0.2906 1
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0141 0.0345
Schistosoma mansoni ap endonuclease 0.0015 0.0042 0.0063
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0141 0.0802
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0038 0.0276 0.0816
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0514 0.066
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0042 0.0018
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0044 0.0336 0.2033
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0017 0.0064 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0337 0.0365
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.1096 0.1096
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0064 0.0186
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0031 0.0031
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0032 0.0216 0.1276
Echinococcus granulosus neuropeptide s receptor 0.0452 0.4469 0.4469
Leishmania major DNA polymerase kappa, putative 0.0017 0.0064 0.0316
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0064 0.0343
Toxoplasma gondii cathepsin CPL 0.0044 0.0337 0.103
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.004 0.0297 0.0381
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.005 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0336 0.0363
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0025 0.0141 0.0802
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0337 0.0365
Entamoeba histolytica protein kinase rad3, putative 0.0025 0.0141 0.0837
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0064 0.0208
Brugia malayi MH2 domain containing protein 0.0019 0.0078 0.0101
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0124 0.0183
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0141 0.0141
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.005 0.0073
Entamoeba histolytica hypothetical protein 0.007 0.0603 0.4756
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.005 0.0395 0.1232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0949 0.1055
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0124 0.014
Mycobacterium leprae Probable lipase LipE 0.0043 0.033 0.3008
Chlamydia trachomatis SWIB complex protein 0.0298 0.2906 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0044 0.0337 0.0337
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0124 0.016
Leishmania major phosphatidylinositol 3-kinase, putative 0.0044 0.0336 0.2033
Echinococcus granulosus cathepsin L 0.0023 0.012 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0678 0.0748
Echinococcus multilocularis Ankyrin 0.0014 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0375 0.3695 0.4744
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0031 0.004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0223
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2706 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0028 0.0169 0.0175
Plasmodium falciparum glutathione reductase 0.0046 0.0352 0.1082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0124 0.016
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0025 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0043 0.033 0.0424
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.088 0.0977
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.005 0.0064
Trypanosoma brucei protein kinase, putative 0.0049 0.0388 0.2382
Echinococcus multilocularis geminin 0.0267 0.2596 0.2596
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0124 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.088 0.0977
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0298 0.2906 1
Schistosoma mansoni lamin 0.004 0.0297 0.0438
Brugia malayi cathepsin F-like cysteine proteinase 0.0015 0.0037 0.0048
Plasmodium falciparum thioredoxin reductase 0.0016 0.005 0.0025
Onchocerca volvulus 0.003 0.0189 0.0213
Echinococcus granulosus TGF beta signal transducer SmadC 0.0019 0.0078 0.0078
Schistosoma mansoni cpg binding protein 0.0078 0.0677 0.0999
Brugia malayi CXXC zinc finger family protein 0.0074 0.0635 0.0815
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0388 0.0498
Onchocerca volvulus 0.0044 0.0337 0.038
Echinococcus multilocularis musashi 0.004 0.0297 0.0297
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0017 0.0064 0.0082
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.005 0.0395 1
Echinococcus granulosus neuropeptide receptor A26 0.0452 0.4469 0.4469
Brugia malayi Pre-SET motif family protein 0.0113 0.1036 0.133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1597 1
Echinococcus granulosus single minded 2 0.0035 0.0246 0.0246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1597 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0044 0.0007
Entamoeba histolytica hypothetical protein 0.007 0.0603 0.4756
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.005 0.0395 0.0395
Echinococcus granulosus lamin dm0 0.004 0.0297 0.0297
Leishmania major hypothetical protein, conserved 0.0025 0.0139 0.0786
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0019 0.0084 0.0084
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0161 0.0207
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.005 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0113 0.1036 0.1529
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0131 0.1222 0.1803
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0064 0.0343
Echinococcus multilocularis ring and YY1 binding protein 0.0106 0.0962 0.0962
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0608 0.067
Schistosoma mansoni hypothetical protein 0.007 0.0603 0.089
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0044 0.0065
Plasmodium vivax vivapain-2 0.0044 0.0337 0.1046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0342 0.0342
Mycobacterium tuberculosis Conserved protein 0.0043 0.033 0.108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0336 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0064 0.0343
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0106 0.0962 0.1084
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0124 0.016
Mycobacterium tuberculosis Conserved protein 0.0043 0.033 0.108
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0064 0.0064
Brugia malayi intermediate filament protein 0.004 0.0297 0.0381
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.005 0.025
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0106 0.0962 0.599
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0017
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0141 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0044 0.0337 0.0365
Schistosoma mansoni lamin 0.004 0.0297 0.0438
Echinococcus multilocularis smad 0.0019 0.0078 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0298 0.2906 0.3263
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0124 0.016
Loa Loa (eye worm) ctsf protein 0.0044 0.0337 0.0433
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.016
Loa Loa (eye worm) hypothetical protein 0.0039 0.0289 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0949 0.1055
Loa Loa (eye worm) hypothetical protein 0.0146 0.1369 0.1758
Echinococcus granulosus cathepsin l1 0.003 0.0189 0.0189
Brugia malayi hypothetical protein 0.0371 0.3647 0.4683
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0028 0.0169 0.0218
Leishmania major hypothetical protein, conserved 0.0106 0.0962 0.599
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.013 0.1205 0.1779
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.005 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0113 0.1036 0.1529
Brugia malayi Cathepsin L-like cysteine proteinase 0.003 0.0189 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0124 0.016
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.0962 0.6001
Schistosoma mansoni ferritin 0.0017 0.0062 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0064 0.0343
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.1096 0.1096
Echinococcus granulosus Ankyrin 0.0014 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0267 0.2596 0.3832
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1597 1
Echinococcus multilocularis ferritin 0.0017 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0058 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0337 0.0365
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0017
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0358 0.0358
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0031 0.0031
Brugia malayi beta-lactamase family protein 0.0043 0.033 0.0424
Echinococcus granulosus phd:f box containing protein 0.0015 0.0044 0.0044
Onchocerca volvulus 0.004 0.0297 0.0334
Schistosoma mansoni apoferritin-2 0.0017 0.0062 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0084 0.0079
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0044 0.0065
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0158 0.0203
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0044 0.0336 0.0496
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0017
Schistosoma mansoni ferritin light chain 0.0017 0.0062 0.0092
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0154 0.1449 0.9064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0064 0.0316
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0044 0.0044
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1597 1
Echinococcus multilocularis zinc finger protein Ran binding 0.0106 0.0962 0.0962
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0013 0.002
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0388 0.2361
Echinococcus multilocularis mothers against decapentaplegic 5 0.0019 0.0078 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0131 0.1222 0.1363
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1597 1
Brugia malayi MH2 domain containing protein 0.0274 0.2669 0.3428
Schistosoma mansoni smad1 5 8 and 0.0019 0.0078 0.0116
Schistosoma mansoni hypothetical protein 0.0106 0.0962 0.142
Schistosoma mansoni intermediate filament proteins 0.004 0.0297 0.0438
Brugia malayi hypothetical protein 0.0025 0.0139 0.0178
Giardia lamblia Histone acetyltransferase GCN5 0.0035 0.0244 0.1708
Trypanosoma cruzi WLM domain containing protein, putative 0.0106 0.0962 0.599
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0371 0.0547
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0131 0.1222 1
Loa Loa (eye worm) hypothetical protein 0.0371 0.3647 0.4683
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0243
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0514 0.0514
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0116 0.0116
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.033 0.108
Schistosoma mansoni RNA binding protein 0.0106 0.0962 0.142
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0514 0.0759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.088 0.0977
Giardia lamblia DINP protein human, muc B family 0.0017 0.0064 0.0186
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0124 0.016
Trichomonas vaginalis helicase, putative 0.0017 0.0058 0.0049
Schistosoma mansoni cathepsin F (C01 family) 0.0044 0.0337 0.0498
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0019 0.0086 0.0086
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0472 0.0472
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.005 0.0395 0.335
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.012 0.0177
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.033 0.0356
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.033 0.273
Entamoeba histolytica hypothetical protein 0.007 0.0603 0.4756
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0342 0.0505
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0044 0.0336 0.2055
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0042 0.0178
Leishmania major cathepsin L-like protease 0.0168 0.1597 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.088 0.0977
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0064 0.0083
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0017 0.0063 0.0468
Schistosoma mansoni brg-1 associated factor 0.0298 0.2906 0.429
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0124 0.0183
Onchocerca volvulus Cathepsin L homolog 0.0044 0.0337 0.038
Echinococcus granulosus histone acetyltransferase KAT2B 0.0126 0.1168 0.1168
Brugia malayi hypothetical protein 0.0012 0.0013 0.0017
Plasmodium vivax glutathione reductase, putative 0.0046 0.0352 0.1098
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0058 0.0049
Entamoeba histolytica cysteine protease, putative 0.0044 0.0337 0.2501
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0388 0.1206
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0388 0.2361
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0064 0.0095
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0388 0.0388
Entamoeba histolytica hypothetical protein 0.0025 0.0141 0.0837
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.005 0.0395 0.363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0685 0.0757
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0124 0.016
Loa Loa (eye worm) hypothetical protein 0.0105 0.0957 0.1229
Leishmania major cathepsin L-like protease 0.0044 0.0337 0.2041
Onchocerca volvulus 0.0433 0.4276 0.4817
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.016
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.005 0.0068
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0124 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0337 0.0365
Entamoeba histolytica acetyltransferase, GNAT family 0.0035 0.0244 0.1708
Brugia malayi N-terminal motif family protein 0.0176 0.1677 0.2154
Loa Loa (eye worm) glutathione reductase 0.0046 0.0352 0.0452
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0023 0.012 0.0177
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0141 0.0181
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0145 0.1361 0.1361
Echinococcus multilocularis Smad4 0.0019 0.0078 0.0078
Onchocerca volvulus 0.0012 0.0014 0.0016
Onchocerca volvulus 0.0043 0.033 0.0372
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.005 0.025
Onchocerca volvulus Cathepsin F homolog 0.0044 0.0337 0.038
Onchocerca volvulus 0.0113 0.1036 0.1167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0131 0.1222 0.1363
Trypanosoma cruzi cysteine peptidase, putative 0.0023 0.012 0.0668
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0358 0.0358
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0044 0.0336 0.0336
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.033 0.1994
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0017
Brugia malayi Cytochrome P450 family protein 0.0022 0.0113 0.0145
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0124 0.014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0337 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0609 0.0671
Leishmania major hypothetical protein, conserved 0.0015 0.0044 0.019
Onchocerca volvulus 0.0044 0.0337 0.038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0342 0.0342
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0124 0.0124
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0388 0.2361
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.033 0.108
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0017 0.0064 0.0316
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0028 0.0169 0.0175
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1597 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0064 0.0343
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0388 0.0388
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0124 0.014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.005 0.0223
Entamoeba histolytica cysteine protease, putative 0.0023 0.012 0.0658
Echinococcus multilocularis cathepsin L cysteine protease 0.0044 0.0337 0.0337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0098 0.088 0.0977
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0145 0.1361 0.1361
Brugia malayi Thioredoxin reductase 0.0046 0.0352 0.0452
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.033 0.108
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.005 0.0395 0.1232
Schistosoma mansoni hypothetical protein 0.0014 0.0031 0.0046
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0131 0.1222 0.763
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0139 0.0336
Echinococcus granulosus death domain containing protein 0.0014 0.0031 0.0031
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0124 0.016
Brugia malayi MAP kinase sur-1 0.0049 0.0388 0.0498
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0131 0.1222 0.763
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.1096 0.1617
Loa Loa (eye worm) hypothetical protein 0.0314 0.307 0.3942
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0044 0.019
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0472 0.0472
Entamoeba histolytica cysteine protease, putative 0.0023 0.012 0.0658
Loa Loa (eye worm) MH2 domain-containing protein 0.0274 0.2669 0.3428
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0014 0.0014
Onchocerca volvulus 0.0886 0.8878 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0131 0.1222 0.1222
Onchocerca volvulus Cathepsin L homolog 0.0044 0.0337 0.038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0057
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.016
Schistosoma mansoni cathepsin F (C01 family) 0.003 0.0189 0.0279
Echinococcus granulosus microtubule associated protein 2 0.0674 0.6724 0.6724
Trypanosoma brucei hypothetical protein, conserved 0.0106 0.0962 0.6001
Mycobacterium tuberculosis Conserved protein 0.0043 0.033 0.108
Loa Loa (eye worm) intermediate filament protein 0.004 0.0297 0.0381
Plasmodium vivax vivapain-1 0.0023 0.012 0.0288
Echinococcus multilocularis sodium channel protein 0.0032 0.0216 0.0216
Echinococcus multilocularis expressed protein 0.0017 0.0062 0.0062
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0033 0.0221 0.067
Leishmania major protein kinase, putative 0.0017 0.0057 0.0272
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0388 0.0422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0949 0.1055
Brugia malayi PAS domain containing protein 0.0048 0.0371 0.0476
Echinococcus granulosus intermediate filament protein 0.004 0.0297 0.0297
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0337 0.2041
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0145 0.1361 0.1361
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0388 0.0388
Trypanosoma cruzi cysteine peptidase, putative 0.0168 0.1597 1
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.033 0.2016
Plasmodium falciparum cysteine proteinase falcipain 3 0.0044 0.0337 0.103
Brugia malayi nuclear receptor RXR 0.0012 0.0013 0.0017
Entamoeba histolytica cysteine protease, putative 0.0023 0.012 0.0658
Echinococcus multilocularis lamin 0.004 0.0297 0.0297
Brugia malayi jmjC domain containing protein 0.0062 0.0514 0.066
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.033 0.108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0337 0.0365
Schistosoma mansoni coup transcription factor 0.0023 0.0124 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0388 0.0572
Giardia lamblia GTOR 0.0131 0.1222 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0124 0.0124
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0298 0.2906 1
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0062 0.0187
Schistosoma mansoni netrin receptor unc5 0.0014 0.0031 0.0046
Echinococcus multilocularis Protein lozenge 0.0054 0.0439 0.0439
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0064 0.0316
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0106 0.0962 0.1236
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0106 0.0962 0.6001
Echinococcus multilocularis tumor protein p63 0.0997 1 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0131 0.1222 0.763
Loa Loa (eye worm) hypothetical protein 0.0159 0.1506 0.1933
Schistosoma mansoni hypothetical protein 0.0019 0.0084 0.0124
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0246 0.0246
Schistosoma mansoni hypothetical protein 0.0145 0.1361 0.2009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.0678 0.0748
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0044 0.0337 0.0433
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0131 0.1222 0.763
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0062 0.0456
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0078 0.0101
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0131 0.1222 0.1569
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0062 0.0074
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0055 0.0443 0.2727
Brugia malayi Cathepsin L-like precursor 0.003 0.0189 0.0243
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0352 0.1163
Loa Loa (eye worm) phosphatidylinositol 3 0.0131 0.1222 0.1569
Toxoplasma gondii ran binding protein 0.0106 0.0962 0.3212
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0038 0.0276 0.0295
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0124 0.0124
Brugia malayi Cathepsin L-like precursor 0.003 0.0189 0.0243
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.012 0.0658
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0352 0.2136
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0124 0.016
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0131 0.1222 0.1222
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0388 0.2361
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0013 0.0013
Echinococcus multilocularis neuropeptide s receptor 0.0452 0.4469 0.4469
Entamoeba histolytica cysteine proteinase 2 0.0023 0.012 0.0658
Echinococcus multilocularis SWI:SNF matrix associated 0.0298 0.2906 0.2906
Echinococcus granulosus dna polymerase kappa 0.0017 0.0064 0.0064
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0028 0.0169 0.0981
Brugia malayi latrophilin 2 splice variant baaae 0.0314 0.307 0.3942
Trypanosoma cruzi cruzipain precursor, putative 0.0168 0.1597 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0107 0.0978 0.0978
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0028 0.0169 0.0218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0044 0.0337 0.0365
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0048
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.033 0.0356
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0028 0.0169 0.0169
Brugia malayi nuclear hormone receptor 0.0023 0.0124 0.016
Onchocerca volvulus 0.0044 0.0337 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0058 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0459 0.4542 0.5833
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.005 0.0025
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0062 0.0187
Mycobacterium tuberculosis Probable reductase 0.0104 0.0946 0.3391
Entamoeba histolytica cysteine protease, putative 0.0023 0.012 0.0658
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0189 0.1244
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.004
Onchocerca volvulus 0.004 0.0297 0.0334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0337 0.0365
Leishmania major cathepsin L-like protease 0.0044 0.0337 0.2041
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.012 0.0658
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0124 0.0183
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0139 0.0336
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0058 0.0049
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0019 0.0029
Onchocerca volvulus 0.0298 0.2906 0.3274
Trichomonas vaginalis bromodomain-containing protein, putative 0.0038 0.0276 0.0295
Loa Loa (eye worm) hypothetical protein 0.0145 0.1361 0.1748
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0064 0.0316
Plasmodium falciparum glutathione reductase 0.0016 0.005 0.0025
Echinococcus multilocularis cathepsin L cysteine protease 0.0044 0.0337 0.0337
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0246 0.193
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0106 0.0962 0.0962
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0336 0.0431
Loa Loa (eye worm) hypothetical protein 0.0433 0.4276 0.5491
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0062 0.0074
Echinococcus multilocularis neuropeptide receptor A26 0.0452 0.4469 0.4469
Brugia malayi hypothetical protein 0.0012 0.0013 0.0017
Onchocerca volvulus Huntingtin homolog 0.0105 0.0957 0.1078
Schistosoma mansoni ap endonuclease 0.0015 0.0042 0.0063
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0113 0.1036 0.1036
Brugia malayi brahma associated protein 60 kDa 0.0298 0.2906 0.3732
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0168 0.1597 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.005 0.0025
Plasmodium vivax vivapain-3 0.0023 0.012 0.0288
Brugia malayi MH1 domain containing protein 0.0019 0.0078 0.0101
Schistosoma mansoni fkbp-rapamycin associated protein 0.0025 0.0141 0.0208
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.005 0.005
Brugia malayi jmjC domain containing protein 0.0015 0.0044 0.0057
Echinococcus granulosus lamin 0.004 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.004 0.0297 0.0381
Brugia malayi Calcitonin receptor-like protein seb-1 0.0459 0.4542 0.5833
Trypanosoma brucei unspecified product 0.0017 0.0064 0.0343
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0031 0.0046
Entamoeba histolytica cysteine protease, putative 0.0023 0.012 0.0658
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.033 0.1994
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0124 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0044 0.0337 0.0365
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0013 0.002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1064 0.3834
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0058 0.0049
Loa Loa (eye worm) hypothetical protein 0.005 0.0395 0.0507
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.012 0.0119
Echinococcus granulosus ring and YY1 binding protein 0.0106 0.0962 0.0962
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0342 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0949 0.1055
Echinococcus granulosus mothers against decapentaplegic 5 0.0019 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0106 0.0962 0.1236
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.005 0.0223
Brugia malayi hypothetical protein 0.0375 0.3695 0.4744
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0649 0.647 0.647
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.005 0.025
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0388 0.2361
Echinococcus granulosus histone acetyltransferase KAT2B 0.0038 0.0276 0.0276
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0017 0.0063 0.0596
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0141 0.0181
Leishmania major cathepsin L-like protease 0.0044 0.0337 0.2041
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0037 0.0145
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0113 0.1036 0.1529
Brugia malayi brahma associated protein 60 kDa 0.0298 0.2906 0.3732
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.033 0.108
Trypanosoma cruzi major cysteine proteinase, putative 0.0132 0.1231 0.769
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0113 0.1036 0.1529
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0062 0.0519 0.321
Schistosoma mansoni hypothetical protein 0.0076 0.0656 0.0968
Loa Loa (eye worm) acetyltransferase 0.013 0.1205 0.1548
Leishmania major cathepsin L-like protease 0.0044 0.0337 0.2041
Onchocerca volvulus 0.0043 0.033 0.0372
Entamoeba histolytica cysteine protease, putative 0.0023 0.012 0.0658
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0028 0.0169 0.0169
Brugia malayi Latrophilin receptor protein 2 0.0145 0.1361 0.1748
Loa Loa (eye worm) transcription factor SMAD2 0.0274 0.2669 0.3428
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0014 0.0014
Loa Loa (eye worm) cysteine protease 0.0044 0.0337 0.0433
Echinococcus granulosus cathepsin L cysteine protease 0.0023 0.012 0.012
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.005 0.0203
Schistosoma mansoni cpg binding protein 0.0074 0.0635 0.0937
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0106 0.0962 0.1236
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0342 0.0342
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1064 0.3834
Leishmania major cathepsin L-like protease 0.0044 0.0337 0.2041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0685 0.0757
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0124 0.0124
Echinococcus multilocularis dna polymerase kappa 0.0017 0.0064 0.0064
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.012 0.0154
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0017 0.0063 0.0091
Echinococcus granulosus cathepsin L cysteine proteinase 0.0044 0.0337 0.0337
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0042 0.0032
Echinococcus granulosus SWI:SNF matrix associated 0.0298 0.2906 0.2906
Schistosoma mansoni smad 0.0019 0.0078 0.0116
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0342 0.0439
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0028 0.0169 0.0461
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0064 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0131 0.1222 0.1363
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0106 0.0962 0.1236
Echinococcus multilocularis survival motor neuron protein 1 0.0371 0.3647 0.3647
Brugia malayi Death domain containing protein 0.0014 0.0031 0.004
Loa Loa (eye worm) hypothetical protein 0.0043 0.033 0.0424
Trypanosoma cruzi cysteine proteinase, putative 0.0023 0.012 0.0668
Onchocerca volvulus 0.0023 0.0124 0.014
Brugia malayi hypothetical protein 0.0105 0.0957 0.1229
Echinococcus multilocularis GPCR, family 2 0.0145 0.1361 0.1361
Trypanosoma cruzi WLM domain containing protein, putative 0.0106 0.0962 0.599
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0055 0.0046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0342 0.0342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0336 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0685 0.0757
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0139 0.0786
Onchocerca volvulus 0.0106 0.0962 0.1084
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0124 0.016
Onchocerca volvulus Huntingtin homolog 0.0105 0.0957 0.1078
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0044 0.0337 0.0365
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0014 0.0014
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.005 0.0395 0.1317
Entamoeba histolytica cysteine protease, putative 0.0023 0.012 0.0658
Loa Loa (eye worm) hypothetical protein 0.0043 0.033 0.0424
Trypanosoma cruzi cruzipain precursor, putative 0.0015 0.0037 0.0145
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0028 0.0169 0.0981
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0106 0.0962 0.1236
Schistosoma mansoni cathepsin F (C01 family) 0.0044 0.0337 0.0498
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0058 0.0049

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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