Detailed information for compound 1385462

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 396.436 | Formula: C22H24N2O5
  • H donors: 2 H acceptors: 3 LogP: 3.8 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c(=O)c(C(=O)NCc2ccc(c(c2)OC)OC)c(c2c1cccc2)O
  • InChi: 1S/C22H24N2O5/c1-4-11-24-16-8-6-5-7-15(16)20(25)19(22(24)27)21(26)23-13-14-9-10-17(28-2)18(12-14)29-3/h5-10,12,25H,4,11,13H2,1-3H3,(H,23,26)
  • InChiKey: UEFBBMRZSJITOF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens arachidonate 12-lipoxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 12-lipoxygenase 663 aa 662 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0057 0.0051 0.0043
Loa Loa (eye worm) hypothetical protein 0.0374 0.0763 0.076
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0067 0.0073 0.356
Toxoplasma gondii protein kinase domain-containing protein 0.0085 0.0114 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.0291 0.0288
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0085 0.0114 1
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0291 0.1822
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0067 0.0073 0.007
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Loa Loa (eye worm) TK protein kinase 0.0057 0.0051 0.0048
Leishmania major protein kinase, putative 0.0085 0.0114 1
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0057 0.0051 0.0268
Entamoeba histolytica protein kinase, putative 0.0085 0.0114 0.0417
Loa Loa (eye worm) TK/Met protein kinase 0.0057 0.0051 0.0048
Schistosoma mansoni regulator of G protein signaling 0.0728 0.1557 0.1537
Loa Loa (eye worm) hypothetical protein 0.012 0.0193 0.0191
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Schistosoma mansoni fibrocystin l 0.0164 0.0291 0.0268
Loa Loa (eye worm) TK/DDR protein kinase 0.0057 0.0051 0.0048
Loa Loa (eye worm) PH domain-containing protein 0.0067 0.0073 0.007
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0114 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0291 0.1822
Echinococcus granulosus GRB2 associated binding protein 3 0.0067 0.0073 0.007
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0057 0.0051 0.0036
Loa Loa (eye worm) RGC/RGC protein kinase 0.0057 0.0051 0.0048
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Trypanosoma cruzi hypothetical protein 0.0067 0.0073 0.356
Echinococcus multilocularis regulator of G protein signaling 3 0.0728 0.1557 0.1847
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0057 0.0051 0.0043
Brugia malayi C-terminal src kinase protein 1 0.0057 0.0051 0.0036
Trichomonas vaginalis centaurin/arf, putative 0.0067 0.0073 0.0416
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0067 0.0073 0.007
Schistosoma mansoni plexin 0.0507 0.1061 0.104
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Echinococcus multilocularis Ras associated and pleckstrin y 0.0067 0.0073 0.007
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Echinococcus granulosus tyrosine protein kinase Src64B 0.0057 0.0051 0.0043
Plasmodium falciparum serine/threonine protein kinase, putative 0.008 0.0103 0.8285
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0164 0.0291 0.1822
Leishmania major cathepsin L-like protease 0.0077 0.0096 0.7222
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Trichomonas vaginalis protein kinase atn1, putative 0.0057 0.0051 0.0272
Brugia malayi PH domain containing protein 0.0067 0.0073 0.0058
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0048
Schistosoma mansoni rho gtpase activating protein 0.0067 0.0073 0.005
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0073 0.0148
Echinococcus granulosus myotubularin protein 13 0.0067 0.0073 0.007
Onchocerca volvulus 0.0057 0.0051 0.0268
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0075 0.0091 0.644
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Echinococcus granulosus tyrosine protein kinase HCK 0.0057 0.0051 0.0043
Entamoeba histolytica protein kinase domain containing protein 0.008 0.0103 0.0345
Schistosoma mansoni protein kinase 0.0057 0.0051 0.0028
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0048
Loa Loa (eye worm) sema domain-containing protein 0.0374 0.0763 0.076
Echinococcus granulosus regulator of G protein signaling 7 0.0728 0.1557 0.1847
Echinococcus multilocularis exocyst complex component 2 0.0164 0.0291 0.0331
Schistosoma mansoni syntrophin 0.0067 0.0073 0.005
Trypanosoma cruzi Protein kinase B 0.0085 0.0114 1
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0057 0.0051 0.0048
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0085 0.0114 1
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0085 0.0114 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0057 0.0051 0.0043
Schistosoma mansoni hypothetical protein 0.0374 0.0763 0.0741
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0057 0.0051 0.0268
Loa Loa (eye worm) hypothetical protein 0.0115 0.0182 0.0179
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.0051 0.0043
Entamoeba histolytica PH domain containing protein 0.0067 0.0073 0.0148
Brugia malayi Plexin repeat family protein 0.0881 0.19 0.1888
Brugia malayi TBC domain containing protein 0.0067 0.0073 0.0058
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0114 0.0417
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0073 0.007
Brugia malayi PH domain containing protein 0.0067 0.0073 0.0058
Echinococcus granulosus Rho GTPase activating protein 24 0.0067 0.0073 0.007
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0057 0.0051 0.0043
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Echinococcus multilocularis Immunoglobulin 0.0115 0.0182 0.02
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0051 0.0272
Echinococcus multilocularis receptor type guanylyl cyclase 0.0057 0.0051 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus granulosus kinase suppressor of Ras 1 0.0057 0.0051 0.0043
Loa Loa (eye worm) syntrophin-1 0.0067 0.0073 0.007
Loa Loa (eye worm) serine/threonine protein kinase 0.0057 0.0051 0.0048
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0085 0.0114 1
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0067 0.0073 0.0058
Brugia malayi Cadps2 protein 0.0067 0.0073 0.0058
Schistosoma mansoni serine/threonine RGC 0.0057 0.0051 0.0028
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0067 0.0073 0.356
Loa Loa (eye worm) TK/FAK protein kinase 0.0057 0.0051 0.0048
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0149 0.016
Entamoeba histolytica protein kinase, putative 0.0085 0.0114 0.0417
Onchocerca volvulus 0.0057 0.0051 0.0268
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0051 0.0028
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Echinococcus granulosus tyrosine kinase 0.0057 0.0051 0.0043
Trypanosoma brucei protein kinase, putative 0.0075 0.0091 0.644
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0057 0.0051 0.0043
Toxoplasma gondii hypothetical protein 0.0067 0.0073 0.356
Onchocerca volvulus 0.0881 0.19 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0057 0.0051 0.0043
Echinococcus multilocularis myotubularin protein 13 0.0067 0.0073 0.007
Loa Loa (eye worm) uncoordinated protein 104 0.0067 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Brugia malayi Oxysterol-binding protein 0.0067 0.0073 0.0058
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Echinococcus granulosus Immunoglobulin 0.0115 0.0182 0.02
Echinococcus multilocularis hypothetical protein 0.0374 0.0763 0.0895
Echinococcus granulosus pdz domain containing protein 0.0067 0.0073 0.007
Echinococcus multilocularis tyrosine kinase 0.0057 0.0051 0.0043
Schistosoma mansoni hypothetical protein 0.0057 0.0051 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0067 0.0073 0.007
Echinococcus multilocularis tyrosine kinase 0.0057 0.0051 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0048
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0057 0.0051 0.0043
Trypanosoma cruzi hypothetical protein 0.0067 0.0073 0.356
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Onchocerca volvulus 0.0374 0.0763 0.4013
Echinococcus granulosus DCC interacting protein 13 beta 0.0067 0.0073 0.007
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Echinococcus multilocularis epidermal growth factor receptor 0.0057 0.0051 0.0043
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.3762 0.8366 1
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0073 0.0148
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Echinococcus granulosus oxysterol binding protein 9 0.0067 0.0073 0.007
Leishmania major protein kinase, putative 0.0075 0.0091 0.644
Brugia malayi serine/threonine protein kinase 6 0.008 0.0103 0.0088
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0115 0.0182 0.0159
Echinococcus multilocularis insulin receptor 0.0057 0.0051 0.0043
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0048
Onchocerca volvulus 0.0057 0.0051 0.0268
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0067 0.0073 0.356
Loa Loa (eye worm) hypothetical protein 0.0728 0.1557 0.1555
Echinococcus granulosus retinal guanylyl cyclase 2 0.0057 0.0051 0.0043
Schistosoma mansoni myotubularin-related protein 0.0067 0.0073 0.005
Toxoplasma gondii aurora kinase 0.008 0.0103 0.8285
Onchocerca volvulus 0.0057 0.0051 0.0268
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0057 0.0051 0.0048
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0048
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0057 0.0051 0.0043
Loa Loa (eye worm) RGC/RGC protein kinase 0.0057 0.0051 0.0048
Entamoeba histolytica p21-activated kinase 0.0085 0.0114 0.0417
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0067 0.0073 0.007
Schistosoma mansoni hypothetical protein 0.0067 0.0073 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0291 0.1822
Echinococcus multilocularis tyrosine protein kinase Blk 0.0057 0.0051 0.0043
Trypanosoma cruzi PH domain containing protein, putative 0.0067 0.0073 0.356
Echinococcus granulosus cytohesin 1 0.0067 0.0073 0.007
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0115 0.0182 0.0159
Brugia malayi SH2 domain containing protein 0.0057 0.0051 0.0036
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.0051 0.0043
Brugia malayi hypothetical protein 0.0728 0.1557 0.1545
Echinococcus granulosus tyrosine protein kinase Src42A 0.0057 0.0051 0.0043
Echinococcus multilocularis calcium dependent secretion activator 1 0.0067 0.0073 0.007
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0114 0.0417
Brugia malayi hypothetical protein 0.0728 0.1557 0.1545
Schistosoma mansoni regulator of G protein signaling 0.0728 0.1557 0.1537
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Entamoeba histolytica protein kinase domain containing protein 0.0221 0.0419 0.2441
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0048
Brugia malayi integrin-linked kinase 0.0057 0.0051 0.0036
Echinococcus multilocularis tyrosine protein kinase csk 0.0057 0.0051 0.0043
Loa Loa (eye worm) hypothetical protein 0.0374 0.0763 0.076
Echinococcus multilocularis c src tyrosine kinase 0.0057 0.0051 0.0043
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0067 0.0073 0.007
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Echinococcus granulosus tyrosine protein kinase csk 0.0057 0.0051 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0096 0.7222
Brugia malayi Probable exocyst complex component Sec5 0.0164 0.0291 0.0277
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Trypanosoma brucei protein kinase, putative 0.0085 0.0114 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0096 0.7222
Loa Loa (eye worm) AUR protein kinase 0.008 0.0103 0.01
Loa Loa (eye worm) hypothetical protein 0.0728 0.1557 0.1555
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Echinococcus multilocularis regulator of G protein signaling 0.0728 0.1557 0.1847
Trypanosoma brucei aurora B kinase 0.008 0.0103 0.8285
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0728 0.1557 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0057 0.0051 0.0043
Echinococcus multilocularis transfer RNA-Thr 0.0057 0.0051 0.0043
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.008 0.0103 0.0105
Loa Loa (eye worm) TK protein kinase 0.0057 0.0051 0.0048
Echinococcus granulosus Regulator of G protein signaling 20 0.0728 0.1557 0.1847
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.3762 0.8366 0.8366
Brugia malayi probable spectrin beta chain 0.0067 0.0073 0.0058
Echinococcus granulosus receptor type guanylyl cyclase 0.0057 0.0051 0.0043
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0067 0.0073 0.007
Toxoplasma gondii phosphatidylinositol transfer protein 0.0067 0.0073 0.356
Schistosoma mansoni zinc finger protein 0.0067 0.0073 0.005
Trypanosoma cruzi PH domain containing protein, putative 0.0067 0.0073 0.356
Loa Loa (eye worm) hypothetical protein 0.0374 0.0763 0.076
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0051 0.0272
Trichomonas vaginalis centaurin/arf, putative 0.0067 0.0073 0.0416
Echinococcus granulosus beta 1 syntrophin 0.0067 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0048
Loa Loa (eye worm) hypothetical protein 0.0374 0.0763 0.076
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0073 0.0148
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Entamoeba histolytica protein kinase domain containing protein 0.0075 0.0091 0.0268
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Echinococcus multilocularis semaphorin 5B 0.0374 0.0763 0.0895
Echinococcus multilocularis epidermal growth factor receptor 0.0057 0.0051 0.0043
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0067 0.0073 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Loa Loa (eye worm) TK protein kinase 0.0057 0.0051 0.0048
Schistosoma mansoni hypothetical protein 0.0067 0.0073 0.005
Schistosoma mansoni protein kinase 0.0057 0.0051 0.0028
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0067 0.0073 0.0148
Echinococcus granulosus pleckstrin y domain containing family A 0.0067 0.0073 0.007
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0067 0.0073 0.005
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Onchocerca volvulus Tyrosine kinase homolog 0.0057 0.0051 0.0268
Plasmodium vivax hypothetical protein, conserved 0.0067 0.0073 0.356
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.0051 0.0043
Echinococcus multilocularis transcription factor collier 0.0164 0.0291 0.0331
Schistosoma mansoni dynamin 0.0067 0.0073 0.005
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0057 0.0051 0.0043
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0057 0.0051 0.0043
Schistosoma mansoni serine/threonine protein kinase 0.3442 0.7647 0.7642
Echinococcus granulosus activin receptor type 0.0075 0.0091 0.0092
Echinococcus multilocularis Pleckstrin y 0.0067 0.0073 0.007
Brugia malayi Regulator of G protein signaling domain containing protein 0.0728 0.1557 0.1545
Trypanosoma cruzi hypothetical protein 0.0067 0.0073 0.356
Schistosoma mansoni ephrin receptor 0.0057 0.0051 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Echinococcus multilocularis GRB2 associated binding protein 3 0.0067 0.0073 0.007
Onchocerca volvulus 0.0057 0.0051 0.0268
Loa Loa (eye worm) hypothetical protein 0.012 0.0193 0.0191
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trichomonas vaginalis AGC family protein kinase 0.008 0.0103 0.0608
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus multilocularis activated cdc42 kinase 1 0.0057 0.0051 0.0043
Leishmania major hypothetical protein, conserved 0.0067 0.0073 0.356
Loa Loa (eye worm) TK protein kinase 0.0057 0.0051 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Trichomonas vaginalis kinesin light chain, putative 0.0067 0.0073 0.0416
Echinococcus granulosus activated cdc42 kinase 1 0.0057 0.0051 0.0043
Echinococcus multilocularis beta adrenergic receptor kinase 0.3442 0.7647 0.9139
Brugia malayi bone morphogenetic protein type 1 receptor 0.0057 0.0051 0.0036
Echinococcus multilocularis protein kinase 0.0057 0.0051 0.0043
Onchocerca volvulus 0.0067 0.0073 0.0386
Onchocerca volvulus 0.0067 0.0073 0.0386
Schistosoma mansoni hypothetical protein 0.0164 0.0291 0.0268
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0057 0.0051 0.0272
Schistosoma mansoni ephrin receptor 0.0062 0.0062 0.0039
Entamoeba histolytica hypothetical protein 0.0067 0.0073 0.0148
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Schistosoma mansoni serine/threonine-protein kinase 0.0085 0.0114 0.0091
Leishmania major cathepsin L-like protease 0.0077 0.0096 0.7222
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Schistosoma mansoni dynamin 0.0067 0.0073 0.005
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0067 0.0073 0.0416
Brugia malayi Immunoglobulin I-set domain containing protein 0.012 0.0193 0.0179
Onchocerca volvulus 0.0057 0.0051 0.0268
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0149 0.016
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0085 0.0114 1
Onchocerca volvulus 0.0067 0.0073 0.0386
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0057 0.0051 0.0036
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0096 0.7222
Echinococcus granulosus tyrosine protein kinase Srms 0.0057 0.0051 0.0043
Entamoeba histolytica hypothetical protein, conserved 0.0067 0.0073 0.0148
Brugia malayi PXA domain containing protein 0.0728 0.1557 0.1545
Echinococcus granulosus insulin receptor 0.0057 0.0051 0.0043
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0057 0.0051 0.0043
Brugia malayi hypothetical protein 0.0057 0.0051 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0096 0.7222
Echinococcus granulosus Pleckstrin y 0.0067 0.0073 0.007
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0085 0.0114 1
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Echinococcus multilocularis raf serine:threonine protein kinase 0.0057 0.0051 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Schistosoma mansoni plexin 0.0881 0.19 0.1881
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0057 0.0051 0.0036
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0057 0.0051 0.0028
Schistosoma mansoni goodpasture antigen-binding protein 0.0067 0.0073 0.005
Echinococcus granulosus tyrosine protein kinase pr2 0.0057 0.0051 0.0043
Entamoeba histolytica PH domain containing protein 0.0067 0.0073 0.0148
Brugia malayi Protein kinase domain containing protein 0.03 0.0597 0.0583
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Loa Loa (eye worm) TK/EPH protein kinase 0.0057 0.0051 0.0048
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Brugia malayi PH domain containing protein 0.0067 0.0073 0.0058
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus granulosus exocyst complex component 2 0.0164 0.0291 0.0331
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Loa Loa (eye worm) TK protein kinase 0.0057 0.0051 0.0048
Echinococcus multilocularis heat shock protein 70 0.0057 0.0051 0.0043
Leishmania major serine/threonine-protein kinase a, putative 0.0085 0.0114 1
Brugia malayi serine/threonine kinase 12 0.008 0.0103 0.0088
Echinococcus granulosus retinal guanylyl cyclase 2 0.0057 0.0051 0.0043
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0728 0.1557 1
Trichomonas vaginalis protein tyrosine kinase, putative 0.0057 0.0051 0.0272
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0067 0.0073 0.007
Brugia malayi regulator of G-protein signaling rgs-7 0.0728 0.1557 0.1545
Loa Loa (eye worm) TK/RYK protein kinase 0.0057 0.0051 0.0048
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0164 0.0291 0.1822
Echinococcus multilocularis oxysterol binding protein 3 0.0067 0.0073 0.007
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0067 0.0073 0.0148
Loa Loa (eye worm) SRC-1 0.0057 0.0051 0.0048
Echinococcus multilocularis natriuretic peptide receptor 1 0.0057 0.0051 0.0043
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0057 0.0051 0.0028
Echinococcus multilocularis regulator of G protein signaling 3 0.0728 0.1557 0.1847
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trypanosoma brucei rac serine-threonine kinase, putative 0.0085 0.0114 1
Brugia malayi PH domain containing protein 0.0067 0.0073 0.0058
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus multilocularis roundabout 2 0.012 0.0193 0.0214
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Onchocerca volvulus 0.0067 0.0073 0.0386
Onchocerca volvulus 0.0057 0.0051 0.0268
Loa Loa (eye worm) PXA domain-containing protein 0.0728 0.1557 0.1555
Onchocerca volvulus 0.0057 0.0051 0.0268
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0057 0.0051 0.0048
Giardia lamblia Aurora kinase 0.008 0.0103 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0085 0.0114 1
Trichomonas vaginalis STE family protein kinase 0.0057 0.0051 0.0272
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0057 0.0051 0.0043
Brugia malayi Furin-like cysteine rich region family protein 0.0057 0.0051 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0291 0.1822
Echinococcus granulosus tyrosine protein kinase 0.0057 0.0051 0.0043
Echinococcus granulosus tyrosine kinase 0.0057 0.0051 0.0043
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0067 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.0728 0.1557 0.1555
Leishmania major cathepsin L-like protease 0.0077 0.0096 0.7222
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0067 0.0073 0.0416
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0067 0.0073 0.356
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0291 0.1822
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus granulosus roundabout 2 0.012 0.0193 0.0214
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.008 0.0103 0.0345
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Schistosoma mansoni axis inhibition protein axin 0.0728 0.1557 0.1537
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0057 0.0051 0.0028
Echinococcus multilocularis kinase suppressor of Ras 1 0.0057 0.0051 0.0043
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0067 0.0073 0.007
Loa Loa (eye worm) oxysterol binding protein 0.0067 0.0073 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0096 0.7222
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.1177 0.1391
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0067 0.0073 0.007
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Entamoeba histolytica protein kinase, putative 0.008 0.0103 0.0345
Trichomonas vaginalis AGC family protein kinase 0.008 0.0103 0.0608
Brugia malayi Protein kinase domain containing protein 0.0085 0.0114 0.0099
Echinococcus granulosus activated cdc42 kinase 1 0.0057 0.0051 0.0043
Loa Loa (eye worm) TK/CSK protein kinase 0.0057 0.0051 0.0048
Leishmania major folate/biopterin transporter, putative 0.0085 0.0114 1
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0067 0.0073 0.007
Brugia malayi Dynamin 0.0067 0.0073 0.0058
Schistosoma mansoni protein kinase 0.0075 0.0091 0.0068
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0728 0.1557 0.1537
Echinococcus granulosus axis inhibition protein axin 0.0728 0.1557 0.1847
Echinococcus multilocularis ephrin type A receptor 4 A 0.0057 0.0051 0.0043
Onchocerca volvulus 0.0057 0.0051 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0051 0.0272
Brugia malayi ephrin receptor 1 precursor 0.0057 0.0051 0.0036
Loa Loa (eye worm) AUR protein kinase 0.008 0.0103 0.01
Schistosoma mansoni centaurin alpha 0.0067 0.0073 0.005
Echinococcus multilocularis regulator of G protein signaling 7 0.0728 0.1557 0.1847
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0728 0.1557 0.1555
Entamoeba histolytica hypothetical protein 0.0164 0.0291 0.1594
Loa Loa (eye worm) cytohesin 3 0.0067 0.0073 0.007
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0291 0.1822
Echinococcus multilocularis expressed protein 0.0728 0.1557 0.1847
Trypanosoma cruzi hypothetical protein 0.0067 0.0073 0.356
Brugia malayi Sema domain containing protein 0.0374 0.0763 0.0749
Brugia malayi Immunoglobulin I-set domain containing protein 0.0172 0.031 0.0295
Entamoeba histolytica protein kinase, putative 0.0085 0.0114 0.0417
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0085 0.0114 1
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Echinococcus multilocularis actin binding protein anillin 0.0067 0.0073 0.007
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0085 0.0114 1
Echinococcus multilocularis oxysterol binding protein 1 0.0067 0.0073 0.007
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0075 0.0091 0.644
Schistosoma mansoni vesicular amine transporter 0.0118 0.0188 0.0165
Entamoeba histolytica protein kinase, putative 0.0085 0.0114 0.0417
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0085 0.0114 0.0677
Brugia malayi Uncoordinated protein 104 0.0067 0.0073 0.0058
Onchocerca volvulus 0.0067 0.0073 0.0386
Echinococcus multilocularis cytohesin 1 0.0067 0.0073 0.007
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0085 0.0114 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0057 0.0051 0.0048
Echinococcus multilocularis pdz domain containing protein 0.0067 0.0073 0.007
Schistosoma mansoni hypothetical protein 0.0067 0.0073 0.005
Loa Loa (eye worm) Plekhf2 protein 0.0067 0.0073 0.007
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Toxoplasma gondii hypothetical protein 0.0067 0.0073 0.356
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus granulosus c src tyrosine kinase 0.0057 0.0051 0.0043
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0067 0.0073 0.0148
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0062 0.0062 0.0057
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0051 0.0272
Echinococcus granulosus epidermal growth factor receptor 0.0057 0.0051 0.0043
Echinococcus multilocularis FL cytokine receptor 0.0057 0.0051 0.0043
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0096 0.7222
Schistosoma mansoni protein kinase 0.0075 0.0091 0.0068
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Echinococcus multilocularis DCC interacting protein 13 beta 0.0067 0.0073 0.007
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Echinococcus multilocularis rac serine:threonine kinase 0.0085 0.0114 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0096 0.7222
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Onchocerca volvulus 0.0057 0.0051 0.0268
Schistosoma mansoni tyrosine protein kinase 0.0057 0.0051 0.0028
Schistosoma mansoni protein kinase 0.0057 0.0051 0.0028
Echinococcus granulosus regulator of G protein signaling 3 0.0728 0.1557 0.1847
Echinococcus multilocularis Pleckstrin y 0.0067 0.0073 0.007
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Brugia malayi PH domain containing protein 0.0067 0.0073 0.0058
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0115 0.0182 0.02
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.0051 0.0043
Echinococcus multilocularis neuroglian 0.0115 0.0182 0.02
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Schistosoma mansoni hypothetical protein 0.0058 0.0054 0.0031
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0067 0.0073 0.0386
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0059 0.1329
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0172 0.031 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0085 0.0114 1
Echinococcus multilocularis Immunoglobulin 0.0115 0.0182 0.02
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0073 0.0148
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0067 0.0073 0.0148
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Entamoeba histolytica hypothetical protein 0.0085 0.0114 0.0417
Loa Loa (eye worm) sema domain-containing protein 0.0374 0.0763 0.076
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0057 0.0051 0.0043
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Echinococcus granulosus transcription factor collier 0.0164 0.0291 0.0331
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0057 0.0051 0.0043
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0057 0.0051 0.0043
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0067 0.0073 0.0386
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Onchocerca volvulus Putative zinc finger protein 0.0067 0.0073 0.0386
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Brugia malayi serine/threonine-protein kinase 6 0.008 0.0103 0.0088
Echinococcus multilocularis Rho GTPase activating protein 24 0.0067 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.012 0.0193 0.0191
Echinococcus granulosus Pleckstrin y 0.0067 0.0073 0.007
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0057 0.0051 0.0048
Loa Loa (eye worm) hypothetical protein 0.0115 0.0182 0.0179
Echinococcus granulosus ephrin type A receptor 4 A 0.0057 0.0051 0.0043
Echinococcus granulosus epidermal growth factor receptor 0.0057 0.0051 0.0043
Schistosoma mansoni z-protein (S1r protein) 0.0728 0.1557 0.1537
Schistosoma mansoni protein kinase 0.0057 0.0051 0.0028
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0057 0.0051 0.0043
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0057 0.0051 0.0272
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0057 0.0051 0.0043
Brugia malayi SRC-1 0.0057 0.0051 0.0036
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0057 0.0051 0.0043
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0067 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Plasmodium falciparum protein kinase, putative 0.0075 0.0091 0.644
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Entamoeba histolytica PH domain containing protein 0.0067 0.0073 0.0148
Echinococcus multilocularis tyrosine protein kinase pr2 0.0057 0.0051 0.0043
Echinococcus multilocularis tyrosine protein kinase Srms 0.0057 0.0051 0.0043
Loa Loa (eye worm) TK/EGFR protein kinase 0.0057 0.0051 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Schistosoma mansoni protein tyrosine kinase 0.0057 0.0051 0.0028
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Brugia malayi Sema domain containing protein 0.0374 0.0763 0.0749
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0564 0.0658
Echinococcus granulosus fibroblast growth factor receptor 4 0.0057 0.0051 0.0043
Schistosoma mansoni protein kinase 0.008 0.0103 0.008
Loa Loa (eye worm) TK protein kinase 0.0057 0.0051 0.0048
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trypanosoma cruzi NIMA-related kinase, putative 0.0085 0.0114 1
Loa Loa (eye worm) protein kinase domain-containing protein 0.0057 0.0051 0.0048
Schistosoma mansoni vav2 0.0067 0.0073 0.005
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0728 0.1557 0.1847
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0164 0.0291 0.1822
Trichomonas vaginalis hypothetical protein 0.0067 0.0073 0.0416
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0057 0.0051 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0096 0.7222
Echinococcus granulosus tyrosine protein kinase csk 0.0057 0.0051 0.0043
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0073 0.0148
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.449 1 1
Schistosoma mansoni protein kinase 0.0057 0.0051 0.0028
Entamoeba histolytica hypothetical protein 0.0728 0.1557 1
Echinococcus granulosus dynamin 1 0.0067 0.0073 0.007
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Echinococcus multilocularis tyrosine protein kinase HCK 0.0057 0.0051 0.0043
Loa Loa (eye worm) hypothetical protein 0.0728 0.1557 0.1555
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Loa Loa (eye worm) TK/INSR protein kinase 0.0057 0.0051 0.0048
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0067 0.0073 0.007
Loa Loa (eye worm) TK protein kinase 0.0057 0.0051 0.0048
Schistosoma mansoni serine/threonine protein kinase 0.3442 0.7647 0.7642
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Schistosoma mansoni protein kinase 0.0057 0.0051 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Entamoeba histolytica protein kinase, putative 0.008 0.0103 0.0345
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Plasmodium falciparum oxysterol-binding protein, putative 0.0067 0.0073 0.356
Onchocerca volvulus 0.0057 0.0051 0.0268
Onchocerca volvulus 0.0057 0.0051 0.0268
Schistosoma mansoni regulator of G protein signaling 0.0728 0.1557 0.1537
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0075 0.0091 0.644
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0051 0.0272
Plasmodium vivax PH domain containing protein 0.0067 0.0073 0.356
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Onchocerca volvulus 0.0067 0.0073 0.0386
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0057 0.0051 0.0043
Echinococcus multilocularis tyrosine protein kinase csk 0.0057 0.0051 0.0043
Loa Loa (eye worm) hypothetical protein 0.0164 0.0291 0.0288
Trypanosoma cruzi PH domain containing protein, putative 0.0067 0.0073 0.356
Echinococcus granulosus serine/threonine protein kinase 0.0085 0.0114 0.0118
Leishmania major protein kinase, putative 0.008 0.0103 0.8285
Brugia malayi Tyrosine-protein kinase PR2 0.0057 0.0051 0.0036
Leishmania major protein kinase, putative 0.0085 0.0114 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0057 0.0051 0.0028
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus granulosus calcium dependent secretion activator 1 0.0067 0.0073 0.007
Entamoeba histolytica protein kinase, putative 0.0085 0.0114 0.0417
Echinococcus multilocularis Regulator of G protein signaling 20 0.0728 0.1557 0.1847
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.0728 0.1557 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0096 0.7222
Schistosoma mansoni nephrin 0.012 0.0193 0.017
Brugia malayi Regulator of G protein signaling domain containing protein 0.0728 0.1557 0.1545
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0085 0.0114 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0057 0.0051 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0115 0.0182 0.02
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0085 0.0114 1
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Entamoeba histolytica hypothetical protein 0.0067 0.0073 0.0148
Schistosoma mansoni hypothetical protein 0.0067 0.0073 0.005
Loa Loa (eye worm) hypothetical protein 0.0286 0.0564 0.0562
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0149 0.0126
Schistosoma mansoni oxysterol-binding protein 1 0.0067 0.0073 0.005
Loa Loa (eye worm) TK protein kinase 0.0057 0.0051 0.0048
Schistosoma mansoni hypothetical protein 0.0164 0.0291 0.0268
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0073 0.0148
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Echinococcus granulosus axis inhibition protein axin 0.0728 0.1557 0.1847
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0085 0.0114 1
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Loa Loa (eye worm) AUR protein kinase 0.008 0.0103 0.01
Echinococcus multilocularis aurora kinase A 0.008 0.0103 0.0105
Loa Loa (eye worm) hypothetical protein 0.01 0.0149 0.0146
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0067 0.0073 0.0058
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Loa Loa (eye worm) hypothetical protein 0.0374 0.0763 0.076
Brugia malayi A-kinase anchor protein 10, precursor 0.0728 0.1557 0.1545
Entamoeba histolytica hypothetical protein 0.0164 0.0291 0.1594
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Trichomonas vaginalis protein transport protein sec7, putative 0.0067 0.0073 0.0416
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0067 0.0073 0.007
Loa Loa (eye worm) TK protein kinase 0.0057 0.0051 0.0048
Brugia malayi SH2 domain containing protein 0.0057 0.0051 0.0036
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus granulosus semaphorin 1A 0.0374 0.0763 0.0895
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus granulosus plexin a4 0.1045 0.2268 0.2698
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.3442 0.7647 0.7647
Loa Loa (eye worm) hypothetical protein 0.0507 0.1061 0.1059
Entamoeba histolytica hypothetical protein 0.0728 0.1557 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0054 0.0039
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Loa Loa (eye worm) hypothetical protein 0.0115 0.0182 0.0179
Echinococcus multilocularis dynamin 1 0.0067 0.0073 0.007
Echinococcus multilocularis integrin linked protein kinase 0.0057 0.0051 0.0043
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0057 0.0051 0.0043
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0057 0.0051 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Onchocerca volvulus 0.01 0.0149 0.0783
Onchocerca volvulus outspread protein homolog 0.0067 0.0073 0.0386
Echinococcus granulosus G protein coupled receptor kinase 1 0.2714 0.6014 0.7183
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0067 0.0073 0.0416
Brugia malayi PH domain containing protein 0.0067 0.0073 0.0058
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0096 0.7222
Brugia malayi Immunoglobulin I-set domain containing protein 0.0057 0.0051 0.0036
Echinococcus granulosus serine:threonine protein kinase 12 B 0.008 0.0103 0.0105
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0114 0.0417
Loa Loa (eye worm) hypothetical protein 0.0728 0.1557 0.1555
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0067 0.0073 0.356
Loa Loa (eye worm) TK/ROR protein kinase 0.0057 0.0051 0.0048
Schistosoma mansoni serine/threonine protein kinase 0.449 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0728 0.1557 1
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0057 0.0051 0.0048
Echinococcus granulosus oxysterol binding protein 3 0.0067 0.0073 0.007
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0067 0.0073 0.007
Leishmania major hypothetical protein, conserved 0.0067 0.0073 0.356
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Brugia malayi hypothetical protein 0.0374 0.0763 0.0749
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0048
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0164 0.0291 0.1822
Entamoeba histolytica hypothetical protein 0.0067 0.0073 0.0148
Entamoeba histolytica hypothetical protein 0.0067 0.0073 0.0148
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0075 0.0091 0.644
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0048
Trypanosoma cruzi aurora B kinase, putative 0.008 0.0103 0.8285
Onchocerca volvulus 0.0057 0.0051 0.0268
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0085 0.0114 1
Echinococcus granulosus Pleckstrin y 0.0067 0.0073 0.007
Echinococcus granulosus retinal guanylyl cyclase 2 0.0057 0.0051 0.0043
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0057 0.0051 0.0028
Loa Loa (eye worm) TK/ALK protein kinase 0.03 0.0596 0.0594
Brugia malayi plexin A 0.1045 0.2268 0.2256
Loa Loa (eye worm) RGS-3 protein 0.0728 0.1557 0.1555
Plasmodium falciparum calcium-dependent protein kinase 7 0.0085 0.0114 1
Echinococcus multilocularis plexin a4 0.1045 0.2268 0.2698
Schistosoma mansoni hypothetical protein 0.0067 0.0073 0.005
Trichomonas vaginalis protein transport protein sec7, putative 0.0067 0.0073 0.0416
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Brugia malayi Tyrosine-protein kinase abl-1 0.0057 0.0051 0.0036
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0062 0.0062 0.0057
Schistosoma mansoni protein kinase 0.0057 0.0051 0.0028
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0067 0.0073 0.007
Echinococcus granulosus tyrosine protein kinase ABL1 0.0057 0.0051 0.0043
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.008 0.0103 0.0345
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.008 0.0103 0.0345
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Echinococcus multilocularis protein tyrosine kinase 0.0057 0.0051 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Entamoeba histolytica ARF GTPase activating protein, putative 0.0067 0.0073 0.0148
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0057 0.0051 0.0036
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0067 0.0073 0.0416
Schistosoma mansoni goodpasture antigen-binding protein 0.0067 0.0073 0.005
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0057 0.0051 0.0043
Trypanosoma cruzi hypothetical protein 0.0067 0.0073 0.356
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0051 0.0028
Plasmodium falciparum PH domain-containing protein, putative 0.0067 0.0073 0.356
Echinococcus multilocularis tyrosine protein kinase 0.0057 0.0051 0.0043
Brugia malayi Cytohesin 3 0.0067 0.0073 0.0058
Brugia malayi hypothetical protein 0.0057 0.0051 0.0036
Trypanosoma brucei PH domain containing protein, putative 0.0067 0.0073 0.356
Brugia malayi Dynamin 0.0067 0.0073 0.0058
Brugia malayi PH domain containing protein 0.0067 0.0073 0.0058
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Echinococcus granulosus raf serine:threonine protein kinase 0.0057 0.0051 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0051 0.0272
Plasmodium vivax serine/threonine protein kinase 6, putative 0.008 0.0103 0.8285
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0051 0.0272
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0048
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.0051 0.0043
Trichomonas vaginalis centaurin alpha, putative 0.0067 0.0073 0.0416
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0067 0.0073 0.0416
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Loa Loa (eye worm) TK protein kinase 0.0057 0.0051 0.0048
Brugia malayi PXA domain containing protein 0.0728 0.1557 0.1545
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0057 0.0051 0.0043
Echinococcus multilocularis tyrosine protein kinase csk 0.0057 0.0051 0.0043
Echinococcus granulosus integrin linked protein kinase 0.0057 0.0051 0.0043
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0057 0.0051 0.0272
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0067 0.0073 0.0058
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0048
Entamoeba histolytica hypothetical protein 0.0164 0.0291 0.1594
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0051 0.0028
Schistosoma mansoni hypothetical protein 0.0374 0.0763 0.0741
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus granulosus semaphorin 5B 0.0374 0.0763 0.0895
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0564 0.0658
Echinococcus multilocularis axis inhibition protein axin 0.0728 0.1557 0.1847
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0075 0.0091 0.0092
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0057 0.0051 0.0048
Echinococcus granulosus Oxysterol binding protein 11 0.0067 0.0073 0.007
Schistosoma mansoni axis inhibition protein axin 0.0728 0.1557 0.1537
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0085 0.0114 0.0677
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0073 0.007
Brugia malayi hypothetical protein 0.0067 0.0073 0.0058
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.0051 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Echinococcus multilocularis axis inhibition protein axin 0.0728 0.1557 0.1847
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0057 0.0051 0.0036
Schistosoma mansoni lipoxygenase 0.0067 0.0073 0.005
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0048
Echinococcus multilocularis tyrosine protein kinase Abl 0.0057 0.0051 0.0043
Echinococcus multilocularis beta 1 syntrophin 0.0067 0.0073 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0728 0.1557 1
Schistosoma mansoni protein kinase 0.0075 0.0091 0.0068
Loa Loa (eye worm) hypothetical protein 0.0214 0.0404 0.0401
Onchocerca volvulus 0.0067 0.0073 0.0386
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Onchocerca volvulus Protein melted homolog 0.0067 0.0073 0.0386
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0057 0.0051 0.0043
Loa Loa (eye worm) hypothetical protein 0.0164 0.0291 0.0288
Trypanosoma cruzi PH domain containing protein, putative 0.0067 0.0073 0.356
Echinococcus multilocularis G protein coupled receptor kinase 6 0.3762 0.8366 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0057 0.0051 0.0043
Echinococcus granulosus tyrosine protein kinase csk 0.0057 0.0051 0.0043
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.3762 0.8366 0.8366
Schistosoma mansoni serine/threonine-protein kinase 0.0085 0.0114 0.0091
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0067 0.0073 0.007
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0067 0.0073 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0067 0.0073 0.0148
Onchocerca volvulus 0.0057 0.0051 0.0268
Trichomonas vaginalis centaurin beta, putative 0.0067 0.0073 0.0416
Schistosoma mansoni zinc finger protein 0.0067 0.0073 0.005
Trichomonas vaginalis centaurin gamma, putative 0.0067 0.0073 0.0416
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0096 0.7222
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Onchocerca volvulus 0.0058 0.0054 0.0285
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0067 0.0073 0.356
Brugia malayi regulator of G-protein signaling egl-10 0.0728 0.1557 0.1545
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0067 0.0073 0.005
Trichomonas vaginalis AGC family protein kinase 0.008 0.0103 0.0608
Schistosoma mansoni semaphorin 5-related 0.0374 0.0763 0.0741
Echinococcus multilocularis Oxysterol binding protein 11 0.0067 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.0728 0.1557 0.1555
Trichomonas vaginalis AGC family protein kinase 0.008 0.0103 0.0608
Brugia malayi hypothetical protein 0.0286 0.0564 0.055
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Loa Loa (eye worm) hypothetical protein 0.0881 0.19 0.1898
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Schistosoma mansoni survival motor neuron protein 0.0058 0.0054 0.0031
Loa Loa (eye worm) hypothetical protein 0.0115 0.0182 0.0179
Echinococcus granulosus regulator of G protein signaling 7 0.0728 0.1557 0.1847
Echinococcus granulosus expressed protein 0.0728 0.1557 0.1847
Echinococcus granulosus natriuretic peptide receptor 1 0.0057 0.0051 0.0043
Brugia malayi protein-tyrosine kinase 0.0057 0.0051 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0728 0.1557 1
Loa Loa (eye worm) TK/ACK protein kinase 0.0057 0.0051 0.0048
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0057 0.0051 0.0028
Echinococcus granulosus aurora kinase A 0.008 0.0103 0.0105
Entamoeba histolytica protein kinase , putative 0.008 0.0103 0.0345
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Onchocerca volvulus 0.0057 0.0051 0.0268
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Echinococcus granulosus twitchin 0.0133 0.0223 0.0249
Brugia malayi Variant SH3 domain containing protein 0.0067 0.0073 0.0058
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Toxoplasma gondii AtPH1 family protein 0.0067 0.0073 0.356
Echinococcus multilocularis protein kinase 0.0057 0.0051 0.0043
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0057 0.0051 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Brugia malayi Pleckstrin Homology Domain 0.0067 0.0073 0.0058
Echinococcus granulosus protein kinase 0.0057 0.0051 0.0043
Entamoeba histolytica protein kinase, putative 0.0085 0.0114 0.0417
Brugia malayi Variant SH3 domain containing protein 0.0067 0.0073 0.0058
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Echinococcus granulosus oxysterol binding protein 1 0.0067 0.0073 0.007
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Loa Loa (eye worm) plexin A 0.1045 0.2268 0.2266
Entamoeba histolytica hypothetical protein 0.0085 0.0114 0.0417
Brugia malayi PH domain containing protein 0.0067 0.0073 0.0058
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0081 0.4833
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0164 0.0291 0.1822
Brugia malayi Guanylyl cyclase protein 23 0.0057 0.0051 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0057 0.0051 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Schistosoma mansoni growth factor receptor-bound protein 0.0067 0.0073 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Loa Loa (eye worm) hypothetical protein 0.0374 0.0763 0.076
Entamoeba histolytica protein kinase, putative 0.0085 0.0114 0.0417
Brugia malayi hypothetical protein 0.012 0.0193 0.0179
Trichomonas vaginalis alpha chimerin, putative 0.0067 0.0073 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0051 0.0272
Loa Loa (eye worm) AGC/AKT protein kinase 0.0085 0.0114 0.0111
Schistosoma mansoni tyrosine kinase 0.0057 0.0051 0.0028
Trypanosoma cruzi hypothetical protein 0.0067 0.0073 0.356
Schistosoma mansoni regulator of G protein signaling 0.0728 0.1557 0.1537
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Echinococcus granulosus tyrosine protein kinase shark 0.0057 0.0051 0.0043
Schistosoma mansoni regulator of G protein signaling 0.0728 0.1557 0.1537
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0067 0.0073 0.007
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0057 0.0051 0.0272
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0057 0.0051 0.0043
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0067 0.0073 0.005
Entamoeba histolytica hypothetical protein 0.0067 0.0073 0.0148
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Entamoeba histolytica cell surface protease gp63, putative 0.0164 0.0291 0.1594
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0073 0.0148
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0114 0.0417
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0075 0.0091 0.0092
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Echinococcus granulosus neuropeptide s receptor 0.0558 0.1177 0.1391
Trichomonas vaginalis conserved hypothetical protein 0.0728 0.1557 1
Brugia malayi Receptor family ligand binding region containing protein 0.0057 0.0051 0.0036
Echinococcus multilocularis protein KINase family member (kin 25) 0.0057 0.0051 0.0043
Schistosoma mansoni hypothetical protein 0.0507 0.1061 0.104
Brugia malayi IPT/TIG domain containing protein 0.0164 0.0291 0.0277
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0067 0.0073 0.007
Loa Loa (eye worm) hypothetical protein 0.0115 0.0182 0.0179
Brugia malayi DNA-binding protein LAG-1 0.0164 0.0291 0.0277
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0051 0.0028
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0085 0.0114 1
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0096 0.7222
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0073 0.0148
Entamoeba histolytica hypothetical protein 0.0728 0.1557 1
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus granulosus beta-adrenergic receptor kinase 0.3442 0.7647 0.9139
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0073 0.0416
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0103 0.008
Echinococcus granulosus tyrosine kinase 0.0057 0.0051 0.0043
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.1177 0.1391
Echinococcus multilocularis regulator of G protein signaling 7 0.0728 0.1557 0.1847
Loa Loa (eye worm) hypothetical protein 0.0057 0.0051 0.0048
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0728 0.1557 0.1847
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0096 0.7222
Echinococcus granulosus tyrosine protein kinase Lyn 0.0075 0.0091 0.0092
Entamoeba histolytica tyrosin kinase, putative 0.0221 0.0419 0.2441
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Entamoeba histolytica hypothetical protein 0.0164 0.0291 0.1594
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus granulosus protein tyrosine kinase 0.0057 0.0051 0.0043
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0057 0.0051 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0096 0.7222
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0057 0.0051 0.0043
Trypanosoma cruzi hypothetical protein 0.0067 0.0073 0.356
Brugia malayi hypothetical protein 0.0374 0.0763 0.0749
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0057 0.0051 0.0043
Loa Loa (eye worm) RGC/RGC protein kinase 0.0057 0.0051 0.0048
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0085 0.0114 1
Echinococcus granulosus neuroglian 0.0115 0.0182 0.02
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0057 0.0051 0.0043
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.1177 0.1391
Echinococcus multilocularis tyrosine protein kinase csk 0.0057 0.0051 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0067 0.0073 0.356
Echinococcus multilocularis tyrosine protein kinase shark 0.0057 0.0051 0.0043
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0114 0.0417
Schistosoma mansoni cell adhesion molecule 0.012 0.0193 0.017
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0096 0.7222
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0149 0.0134
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Brugia malayi Protein kinase domain containing protein 0.0057 0.0051 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0067 0.0073 0.356
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0057 0.0051 0.0036
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Brugia malayi hypothetical protein 0.0057 0.0051 0.0036
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Echinococcus granulosus tyrosine protein kinase Blk 0.0057 0.0051 0.0043
Brugia malayi Syntrophin-1 0.0067 0.0073 0.0058
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0057 0.0051 0.0028
Loa Loa (eye worm) RGC/RGC protein kinase 0.0057 0.0051 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0291 0.1822
Echinococcus multilocularis G protein coupled receptor kinase 1 0.2714 0.6014 0.7183
Toxoplasma gondii Oxysterol-binding protein 0.0067 0.0073 0.356
Trichomonas vaginalis TK family protein kinase 0.0057 0.0051 0.0272
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0067 0.0073 0.0416
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Echinococcus multilocularis oxysterol binding protein 9 0.0067 0.0073 0.007
Trichomonas vaginalis AGC family protein kinase 0.0085 0.0114 0.0677
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0057 0.0051 0.0043
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0057 0.0051 0.0043
Loa Loa (eye worm) rho-GTPase-activating 0.0067 0.0073 0.007
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Brugia malayi PH domain containing protein 0.0067 0.0073 0.0058
Schistosoma mansoni oxysterol-binding protein 1 0.0067 0.0073 0.005
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0015 0.0012
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.0051 0.0043
Echinococcus multilocularis pleckstrin y domain containing family A 0.0067 0.0073 0.007
Echinococcus granulosus regulator of G protein signaling 3 0.0728 0.1557 0.1847
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.3762 0.8366 0.8364
Trypanosoma cruzi NIMA-related kinase, putative 0.0085 0.0114 1
Loa Loa (eye worm) TK/FER protein kinase 0.0057 0.0051 0.0048
Echinococcus multilocularis activin receptor type 0.0075 0.0091 0.0092
Brugia malayi Oxysterol binding protein 0.0067 0.0073 0.0058
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Brugia malayi Fibronectin type III domain containing protein 0.012 0.0193 0.0179
Brugia malayi MAX-1A 0.0067 0.0073 0.0058
Trichomonas vaginalis TKL family protein kinase 0.0057 0.0051 0.0272
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Brugia malayi Plekhf2 protein 0.0067 0.0073 0.0058
Echinococcus granulosus defective proboscis extension response 0.0115 0.0182 0.02
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0067 0.0073 0.0148
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0057 0.0051 0.0043
Loa Loa (eye worm) hypothetical protein 0.0067 0.0073 0.007
Brugia malayi Raf kinase 0.0057 0.0051 0.0036
Echinococcus multilocularis Pleckstrin y 0.0067 0.0073 0.007
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0067 0.0073 0.356
Loa Loa (eye worm) hypothetical protein 0.0115 0.0182 0.0179
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0067 0.0073 0.0148
Schistosoma mansoni protein kinase 0.0057 0.0051 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0051 0.0272
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0728 0.1557 0.1537
Loa Loa (eye worm) hypothetical protein 0.0164 0.0291 0.0288
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0728 0.1557 0.1537

Activities

Activity type Activity value Assay description Source Reference
AbsAC1000_uM (functional) = 2.319 uM PUBCHEM_BIOASSAY: In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504552] ChEMBL. No reference
AbsAC35 (functional) = 21.76 uM PubChem BioAssay. Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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