Detailed information for compound 1394130

Basic information

Technical information
  • TDR Targets ID: 1394130
  • Name: 3-chloro-N-[2-[(2-methyl-3,4-dihydro-1H-isoqu inolin-1-yl)methyl]phenyl]-1-benzothiophene-2 -carboxamide
  • MW: 446.992 | Formula: C26H23ClN2OS
  • H donors: 1 H acceptors: 1 LogP: 6.6 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCc2c(C1Cc1ccccc1NC(=O)c1sc3c(c1Cl)cccc3)cccc2
  • InChi: 1S/C26H23ClN2OS/c1-29-15-14-17-8-2-4-10-19(17)22(29)16-18-9-3-6-12-21(18)28-26(30)25-24(27)20-11-5-7-13-23(20)31-25/h2-13,22H,14-16H2,1H3,(H,28,30)
  • InChiKey: ACKAQJBYLPLIOW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-chloro-N-[2-[(2-methyl-3,4-dihydro-1H-isoquinolin-1-yl)methyl]phenyl]benzothiophene-2-carboxamide
  • 3-chloro-N-[2-[(2-methyl-3,4-dihydro-1H-isoquinolin-1-yl)methyl]phenyl]-2-benzothiophenecarboxamide
  • NSC309874
  • 3-chloro-N-(2-((2-methyl-1,2,3,4-tetrahydro-1-isoquinolinyl)methyl)phenyl)-1-benzothiophene-2-carboxamide
  • NCI60_002657
  • MLS000757035
  • SMR000528910

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis aldo-keto reductase, putative 0.0291 0.5107 1
Plasmodium vivax aldehyde reductase, putative 0.0267 0.4685 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0267 0.4685 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0033 0.0016
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0291 0.5107 0.5099
Echinococcus granulosus calpain 0.0042 0.0595 0.058
Echinococcus multilocularis aldo keto reductase 0.0291 0.5107 0.5099
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0715 0.0796
Treponema pallidum hypothetical protein 0.0019 0.0186 0.5
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.0226 0.0081
Loa Loa (eye worm) calpain 5 0.0029 0.0368 0.0535
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0954 0.1869
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0291 0.5107 0.5099
Brugia malayi RNA, U transporter 1 0.0099 0.1634 0.3177
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0119 0.1997 0.2255
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0267 0.4685 0.7113
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0303 0.0586
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Schistosoma mansoni hypothetical protein 0.0013 0.0066 0.0056
Leishmania major calpain protease-like protein 0.0013 0.0066 0.0129
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0303 0.0287
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0291 0.5107 0.5099
Trypanosoma cruzi aldo/keto reductase, putative 0.0291 0.5107 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.1571 0.2368
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0127 0.0125
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0226 0.0081
Schistosoma mansoni calpain C (C02 family) 0.0042 0.0595 0.0659
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0096 0.1571 0.177
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.0226 0.0081
Plasmodium falciparum aldehyde reductase, putative 0.0267 0.4685 1
Schistosoma mansoni potassium channel beta 0.0267 0.4685 0.5318
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0013 0.0066 0.0129
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0291 0.5107 0.5099
Echinococcus granulosus voltage gated potassium channel subunit 0.0267 0.4685 0.4676
Brugia malayi calpain 5 0.0029 0.0368 0.069
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0127 0.0248
Schistosoma mansoni jumonji domain containing protein 0.006 0.0919 0.1028
Trichomonas vaginalis ran, putative 0.0026 0.0303 0.047
Plasmodium falciparum importin beta, putative 0.0035 0.047 0.0874
Brugia malayi jmjC domain containing protein 0.006 0.0919 0.1774
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0267 0.4685 0.917
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0127 0.0248
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0291 0.5107 1
Echinococcus multilocularis calpain 7 (C02 family) 0.0042 0.0595 0.058
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0226 0.0081
Trypanosoma cruzi conserved protein 0.0013 0.0066 0.0129
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0226 0.0442
Echinococcus granulosus aldo keto reductase 0.0291 0.5107 0.5099
Trichomonas vaginalis aldo-keto reductase, putative 0.0267 0.4685 0.9162
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0954 0.1068
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2453 0.3712
Echinococcus granulosus aldo keto reductase 0.0291 0.5107 0.5099
Plasmodium vivax protease, putative 0.0019 0.0186 0.0397
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0291 0.5107 0.5099
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0291 0.5107 0.5099
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0291 0.5107 0.5099
Trypanosoma brucei Calpain-like protein CALP1.3 0.0013 0.0066 0.0129
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0837 0.0821
Echinococcus multilocularis aldo keto reductase 0.0291 0.5107 0.5099
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0503 0.0955
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0267 0.4685 0.9172
Plasmodium vivax importin-beta 2, putative 0.0035 0.047 0.1003
Trypanosoma brucei antigen, putative 0.0042 0.0595 0.1166
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0226 0.0081
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0119 0.1997 0.1983
Echinococcus multilocularis aldo keto reductase 0.0291 0.5107 0.5099
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0303 0.0594
Mycobacterium ulcerans oxidoreductase 0.0291 0.5107 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0226 0.0081
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0119 0.1997 0.2255
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0715 0.1253
Brugia malayi CAAX amino terminal protease family protein 0.0093 0.1523 0.2958
Brugia malayi jmjC domain containing protein 0.0016 0.0127 0.0216
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0955 0.1069
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0954 0.1762
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0954 0.1869
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0013 0.0066 0.0121
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0226 0.0081
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0954 0.1762
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0042 0.0595 0.1166
Leishmania major cytochrome p450-like protein 0.0032 0.0418 0.0818
Trichomonas vaginalis aldo-keto reductase, putative 0.0291 0.5107 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0503 0.0487
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0226 0.0081
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Trypanosoma brucei Calpain-like protein 1.2 0.0013 0.0066 0.0129
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0503 0.0867
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0595 0.1166
Loa Loa (eye worm) calpain family protein 1 0.0081 0.1316 0.198
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0303 0.0563
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0503 0.0741
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0127 0.0168
Brugia malayi mbt repeat family protein 0.0048 0.0715 0.1372
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.2833 0.4291
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0163 0.0146
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0013 0.0066 0.0129
Onchocerca volvulus 0.0069 0.1088 0.1996
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.658 1
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0093 0.1523 0.2889
Onchocerca volvulus 0.0291 0.5107 1
Echinococcus multilocularis hypothetical protein 0.0042 0.0595 0.058
Onchocerca volvulus 0.0096 0.1571 0.2957
Schistosoma mansoni alpha-glucosidase 0.0142 0.2416 0.2733
Brugia malayi MH2 domain containing protein 0.0144 0.2453 0.4786
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Loa Loa (eye worm) oxidoreductase 0.0291 0.5107 0.7757
Giardia lamblia Hypothetical protein 0.0093 0.1523 0.2538
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0021
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.0226 0.0081
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.0226 0.0081
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0955 0.1069
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0503 0.0487
Schistosoma mansoni ran 0.0026 0.0303 0.0326
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.047 0.0912
Schistosoma mansoni aldo-keto reductase 0.0291 0.5107 0.5799
Echinococcus multilocularis voltage gated potassium channel subunit 0.0267 0.4685 0.4676
Trypanosoma brucei RNA helicase, putative 0.01 0.1652 0.3234
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0226 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0127 0.0168
Echinococcus granulosus phd:f box containing protein 0.0016 0.0127 0.011
Echinococcus granulosus calpain A 0.0119 0.2001 0.1988
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0291 0.5107 0.5099
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.035 0.0686
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0595 0.1166
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0127 0.011
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0033 0.0016
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0418 0.0818
Trichomonas vaginalis aldo/keto reductase, putative 0.0291 0.5107 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0291 0.5107 0.5099
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.2833 0.2821
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0467 0.0687
Brugia malayi jmjC domain containing protein 0.0062 0.0955 0.1844
Loa Loa (eye worm) hypothetical protein 0.0081 0.1316 0.198
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0303 0.0437
Echinococcus granulosus aldo keto reductase 0.0291 0.5107 0.5099
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.1062 0.1592
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0595 0.1166
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0093 0.1523 0.2981
Echinococcus granulosus hypothetical protein 0.0291 0.5107 0.5099
Loa Loa (eye worm) hypothetical protein 0.0014 0.0086 0.0106
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.2833 0.5532
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0267 0.4685 0.9173
Trichomonas vaginalis aldo-keto reductase, putative 0.0291 0.5107 1
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0127 0.0125
Toxoplasma gondii hypothetical protein 0.0019 0.0186 0.0356
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0503 0.0867
Loa Loa (eye worm) hypothetical protein 0.0111 0.1845 0.2786
Plasmodium falciparum aldo-keto reductase, putative 0.0267 0.4685 1
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0127 0.011
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0013 0.0066 0.0129
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0267 0.4685 0.9172
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0291 0.5107 0.5099
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0111 0.1845 0.2083
Brugia malayi mbt repeat family protein 0.0048 0.0715 0.1372
Onchocerca volvulus 0.0096 0.157 0.2956
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0127 0.011
Loa Loa (eye worm) hypothetical protein 0.0035 0.047 0.0691
Brugia malayi Cytochrome P450 family protein 0.0032 0.0418 0.0788
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.0226 0.0081
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0503 0.0867
Entamoeba histolytica CAAX amino terminal protease family 0.0019 0.0186 0.0238
Brugia malayi calpain D 0.0013 0.0066 0.0097
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.0226 0.0081
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Loa Loa (eye worm) calpain 0.0042 0.0595 0.0882
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.0226 0.0081
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0503 0.0867
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0837 0.0821
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Toxoplasma gondii CAAX amino terminal protease family protein 0.0019 0.0186 0.0356
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0291 0.5107 0.5099
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0303 0.0594
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0919 0.0904
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0954 0.1862
Trypanosoma cruzi kinesin, putative 0.0029 0.0368 0.072
Brugia malayi MAP kinase sur-1 0.0062 0.0954 0.1842
Schistosoma mansoni Mername-AA248 (C02 family) 0.0042 0.0595 0.0659
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0503 0.0867
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0503 0.0867
Loa Loa (eye worm) hypothetical protein 0.0093 0.1523 0.2295
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0086 0.0168
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0954 0.1869
Schistosoma mansoni hypothetical protein 0.0494 0.8796 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.0226 0.0081
Entamoeba histolytica CAAX prenyl protease family 0.0093 0.1523 0.2889
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.0226 0.0081
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0127 0.011
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0291 0.5107 0.5099
Mycobacterium leprae Possible oxidoreductase 0.0267 0.4685 0.9135
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0226 0.0081
Trichomonas vaginalis aldo-keto reductase, putative 0.0291 0.5107 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0954 0.1869
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.0226 0.0081
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.047 0.092
Loa Loa (eye worm) calpain family protein 1 0.0111 0.1845 0.2786
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.035 0.0564
Trypanosoma brucei glucosidase, putative 0.0037 0.0503 0.0985
Echinococcus multilocularis CAAX prenyl protease 2 0.0093 0.1523 0.1509
Trypanosoma cruzi kinesin, putative 0.0029 0.0368 0.072
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0291 0.5107 0.5099
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0291 0.5107 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0595 0.1166
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0954 0.0939
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0303 0.0513
Trichomonas vaginalis aldo-keto reductase, putative 0.0291 0.5107 1
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0093 0.1523 0.2981
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0955 0.143
Trichomonas vaginalis conserved hypothetical protein 0.0267 0.4685 0.9162
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Schistosoma mansoni cytochrome P450 0.0021 0.0226 0.0238
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0226 0.0081
Echinococcus granulosus snurportin 1 0.0372 0.658 0.6574
Trypanosoma cruzi aldo/keto reductase, putative 0.0267 0.4685 0.9173
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0418 0.0818
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0119 0.1997 0.1983
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0595 0.1166
Trypanosoma brucei Calpain-like protein 2 0.0013 0.0066 0.0129
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.2833 0.2821
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0127 0.0125
Brugia malayi follicle stimulating hormone receptor 0.0283 0.4963 0.9716
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0837 0.1611
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0837 0.0821
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.8796 0.8794
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0086 0.0168
Trichomonas vaginalis importin beta-1, putative 0.0028 0.035 0.0564
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.0226 0.0081
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0291 0.5107 0.5099
Echinococcus multilocularis calpain 0.0042 0.0595 0.058
Leishmania major cytochrome p450-like protein 0.0021 0.0226 0.0442
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0595 0.1166
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0226 0.0081
Trichomonas vaginalis aldo-keto reductase, putative 0.0291 0.5107 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.035 0.0564
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.0226 0.0081
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0226 0.0442
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0418 0.0611
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0291 0.5107 0.5099
Echinococcus multilocularis snurportin 1 0.0372 0.658 0.6574
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0013 0.0066 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0595 0.1166
Trichomonas vaginalis aldo-keto reductase, putative 0.0291 0.5107 1
Toxoplasma gondii aldo-keto reductase 0.0267 0.4685 0.9172
Echinococcus granulosus importin subunit beta 1 0.0035 0.047 0.0454
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0127 0.011
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0267 0.4685 0.9162
Mycobacterium ulcerans hypothetical protein 0.0267 0.4685 0.9142
Schistosoma mansoni cpg binding protein 0.0037 0.0503 0.0554
Echinococcus granulosus dnaJ subfamily B 0.0494 0.8796 0.8794
Onchocerca volvulus 0.0267 0.4685 0.9159
Trypanosoma brucei kinesin, putative 0.0029 0.0368 0.072
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.3293 0.3282
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Onchocerca volvulus 0.0291 0.5107 1
Schistosoma mansoni calpain-7 (C02 family) 0.0042 0.0595 0.0659
Schistosoma mansoni calpain (C02 family) 0.0042 0.0595 0.0659
Plasmodium vivax JmjC domain containing protein 0.0016 0.0127 0.027
Mycobacterium tuberculosis Conserved protein 0.0267 0.4685 0.9142
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0127 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0503 0.0985
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0127 0.0131
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0291 0.5107 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0267 0.4685 0.9162
Echinococcus granulosus neuropeptide receptor A26 0.056 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0086 0.004
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2453 0.3712
Loa Loa (eye worm) hypothetical protein 0.0048 0.0715 0.1064
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0954 0.1762
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0013 0.0066 0.0129
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0715 0.1064
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0291 0.5107 0.5099
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0503 0.0867
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0086 0.004
Brugia malayi jmjC domain containing protein 0.0016 0.0127 0.0216
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0013 0.0066 0.0129
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0955 0.094
Schistosoma mansoni cpg binding protein 0.0035 0.0467 0.0513
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.103 0.201
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0291 0.5107 1
Onchocerca volvulus 0.0291 0.5107 1
Entamoeba histolytica CAAX amino terminal protease family 0.0019 0.0186 0.0238
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0291 0.5107 1
Trypanosoma brucei CAAX amino terminal protease, putative 0.0093 0.1523 0.2981
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0418 0.0818
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0226 0.0081
Echinococcus granulosus calpain 7 C02 family 0.0042 0.0595 0.058
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Echinococcus granulosus aldehyde reductase 0.0023 0.0261 0.0245
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.0226 0.0081
Loa Loa (eye worm) oxidoreductase 0.0291 0.5107 0.7757
Trypanosoma brucei hypothetical protein 0.0013 0.0066 0.0129
Giardia lamblia Aldose reductase 0.0291 0.5107 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0303 0.0647
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0226 0.0442
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0226 0.0081
Leishmania major kinesin, putative 0.0029 0.0368 0.072
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0291 0.5107 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.1618 0.244
Echinococcus multilocularis aldehyde reductase 0.0023 0.0261 0.0245
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0013 0.0066 0.0129
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0226 0.0081
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0303 0.0287
Brugia malayi calpain family protein 1 0.0111 0.1845 0.3592
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0086 0.004
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0086 0.004
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0226 0.0081
Entamoeba histolytica aldose reductase, putative 0.0291 0.5107 1
Toxoplasma gondii aldose reductase, putative 0.0291 0.5107 1
Leishmania major hypothetical protein, conserved 0.0016 0.0127 0.0248
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0075
Brugia malayi Importin beta-1 subunit 0.0035 0.047 0.089
Brugia malayi Cytochrome P450 family protein 0.0067 0.1062 0.2053
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0013 0.0066 0.0129
Schistosoma mansoni cpg binding protein 0.0037 0.0503 0.0554
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.0226 0.0081
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0503 0.0985
Schistosoma mansoni calpain-2 (C02 family) 0.0013 0.0066 0.0056
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0954 0.0939
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0086 0.004
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0013 0.0066 0.0129
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0595 0.1166
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0595 0.1166
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0303 0.0594
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Trypanosoma brucei calpain, putative 0.0013 0.0066 0.0129
Trichomonas vaginalis aldo-keto reductase, putative 0.0267 0.4685 0.9162
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0127 0.0125
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0226 0.0434
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0226 0.0081
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0033 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0291 0.5107 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.1088 0.1633
Loa Loa (eye worm) hypothetical protein 0.0055 0.0837 0.1249
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.047 0.092
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0226 0.0081
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0031 0.0027
Brugia malayi calpain 7 0.0042 0.0595 0.1137
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0503 0.0867
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0595 0.1166
Toxoplasma gondii hypothetical protein 0.0019 0.0186 0.0356
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0127 0.0168
Schistosoma mansoni hypothetical protein 0.0294 0.5168 0.5868
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0503 0.0867
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0503 0.0985
Echinococcus multilocularis neuropeptide receptor A26 0.056 1 1
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0595 0.1166
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.3293 0.3282
Leishmania major calpain family cysteine protease-like protein 0.0013 0.0066 0.0129
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0954 0.1869
Plasmodium falciparum protease, putative 0.0019 0.0186 0.026
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0086 0.004
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0715 0.0796
Leishmania major hypothetical protein, unknown function 0.0013 0.0066 0.0129
Brugia malayi calpain family protein 1 0.0111 0.1845 0.3592
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0013 0.0066 0.0129
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.0226 0.0081
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0226 0.0442
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Chlamydia trachomatis hypothetical protein 0.0019 0.0186 0.5
Schistosoma mansoni hypothetical protein 0.0372 0.658 0.7476
Loa Loa (eye worm) hypothetical protein 0.0096 0.1571 0.2368
Entamoeba histolytica alcohol dehydrogenase, putative 0.0267 0.4685 0.9162
Giardia lamblia Aldose reductase 0.0291 0.5107 1
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0127 0.011
Schistosoma mansoni pol-related 0.0291 0.5107 0.5799
Trypanosoma brucei aldo/keto reductase, putative 0.0267 0.4685 0.9173
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0954 0.1869
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0093 0.1523 0.1715
Echinococcus granulosus CAAX prenyl protease 2 0.0093 0.1523 0.1509
Brugia malayi calpain 5 0.0013 0.0066 0.0097
Toxoplasma gondii hypothetical protein 0.0013 0.0066 0.0121
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0291 0.5107 0.5099
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0954 0.0939
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0226 0.0081
Trypanosoma brucei cysteine peptidase, putative 0.0013 0.0066 0.0129
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0086 0.0168
Brugia malayi jmjC domain containing protein 0.0016 0.0127 0.0216
Schistosoma mansoni alpha glucosidase 0.0037 0.0503 0.0554
Loa Loa (eye worm) oxidoreductase 0.0291 0.5107 0.7757
Echinococcus multilocularis calpain A 0.0119 0.2001 0.1988
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0013 0.0066 0.0129
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.0226 0.0081
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0595 0.1166
Onchocerca volvulus 0.0048 0.0715 0.1253
Loa Loa (eye worm) hypothetical protein 0.0016 0.0127 0.0168
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0715 0.07
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0127 0.0168
Schistosoma mansoni aldo-keto reductase 0.0291 0.5107 0.5799
Leishmania major prostaglandin f synthase, putative 0.0291 0.5107 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0086 0.004
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Schistosoma mansoni alpha-glucosidase 0.0142 0.2416 0.2733
Brugia malayi Cytochrome P450 family protein 0.0032 0.0418 0.0788
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0093 0.1523 0.1715
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0954 0.1429
Trichomonas vaginalis aldo-keto reductase, putative 0.0291 0.5107 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0595 0.1166
Echinococcus multilocularis importin subunit beta 1 0.0035 0.047 0.0454
Trichomonas vaginalis aldo/keto reductase, putative 0.0291 0.5107 1
Leishmania major aldo-keto reductase-like protein 0.0291 0.5107 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0042 0.0595 0.1166
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0954 0.1355
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0595 0.1166
Entamoeba histolytica Ran family GTPase 0.0026 0.0303 0.047
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0093 0.1523 0.2981
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0954 0.1762
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0418 0.0611
Trichomonas vaginalis aldo-keto reductase, putative 0.0291 0.5107 1
Leishmania major importin beta-1 subunit, putative 0.0028 0.035 0.0686
Echinococcus granulosus calpain 5 0.0042 0.0595 0.058
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0919 0.0904
Mycobacterium tuberculosis Probable oxidoreductase 0.0291 0.5107 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0291 0.5107 0.5099
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0226 0.0081
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0226 0.0081
Echinococcus multilocularis 0.0021 0.0226 0.021
Schistosoma mansoni hypothetical protein 0.0021 0.0226 0.0238
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0086 0.0168
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0163 0.0146
Echinococcus multilocularis calpain family protein 1, d 0.0081 0.1316 0.1301
Schistosoma mansoni hypothetical protein 0.01 0.1652 0.1863
Trypanosoma cruzi aldo-keto reductase 0.0291 0.5107 1
Echinococcus granulosus cpg binding protein 0.0037 0.0503 0.0487
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0715 0.07
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0291 0.5107 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0013 0.0066 0.0129
Echinococcus multilocularis neuropeptide s receptor 0.056 1 1
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0267 0.4685 0.4676
Loa Loa (eye worm) hypothetical protein 0.0291 0.5107 0.7757
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0291 0.5107 0.5099
Brugia malayi cytochrome P450 0.0021 0.0226 0.0411
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0715 0.07
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Brugia malayi jmjC domain containing protein 0.0016 0.0127 0.0216
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0837 0.0821
Trypanosoma brucei protein kinase, putative 0.0062 0.0954 0.1869
Entamoeba histolytica aldose reductase, putative 0.0291 0.5107 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.2833 0.2821
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0127 0.0248
Leishmania major GTP-binding protein, putative 0.0026 0.0303 0.0594
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0086 0.004
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0127 0.024
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.0226 0.0081
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0291 0.5107 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0086 0.004
Onchocerca volvulus 0.0089 0.1458 0.2732
Loa Loa (eye worm) calpain D 0.0013 0.0066 0.0075
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0503 0.0867
Mycobacterium leprae Conserved hypothetical protein 0.0023 0.0261 0.0071
Loa Loa (eye worm) oxidoreductase 0.0291 0.5107 0.7757
Loa Loa (eye worm) oxidoreductase 0.0291 0.5107 0.7757
Echinococcus granulosus calpain A 0.0042 0.0595 0.058
Loa Loa (eye worm) hypothetical protein 0.0016 0.0127 0.0168
Entamoeba histolytica protein kinase, putative 0.003 0.0378 0.0619
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0013 0.0066 0.0129
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0715 0.07
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0226 0.0442
Loa Loa (eye worm) cytochrome P450 0.0021 0.0226 0.0319
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0226 0.021
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0919 0.0904
Echinococcus multilocularis aldo keto reductase 0.0291 0.5107 0.5099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1172 0.1317
Echinococcus multilocularis calpain 5 0.0042 0.0595 0.058
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0837 0.0934
Trichomonas vaginalis aldo-keto reductase, putative 0.0291 0.5107 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.0226 0.0081
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0595 0.1166
Echinococcus multilocularis cpg binding protein 0.0037 0.0503 0.0487
Trypanosoma brucei prostaglandin f synthase 0.0291 0.5107 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0291 0.5107 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0226 0.0081
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0595 0.1166
Trypanosoma brucei aldo-keto reductase, putative 0.0291 0.5107 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0291 0.5107 0.5099
Loa Loa (eye worm) MBCTL1 0.0055 0.0837 0.1249
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0086 0.0136
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0503 0.0867
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0283 0.4963 0.7536
Brugia malayi Trypsin family protein 0.0096 0.1571 0.3053
Brugia malayi NADH-dependent xylose reductase 0.0267 0.4685 0.917
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0291 0.5107 1
Schistosoma mansoni ran 0.0026 0.0303 0.0326
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0954 0.0939
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0127 0.024
Onchocerca volvulus 0.0291 0.5107 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0503 0.0977
Schistosoma mansoni importin beta-1 0.0035 0.047 0.0516
Entamoeba histolytica hypothetical protein 0.0028 0.035 0.0564
Plasmodium vivax calpain, putative 0.0042 0.0595 0.1271
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0418 0.0611
Trichomonas vaginalis aldo/keto reductase, putative 0.0291 0.5107 1
Leishmania major cytochrome p450-like protein 0.0021 0.0226 0.0442
Trypanosoma brucei calpain, putative 0.0013 0.0066 0.0129
Schistosoma mansoni calpain-7 (C02 family) 0.0042 0.0595 0.0659
Brugia malayi CXXC zinc finger family protein 0.0035 0.0467 0.0886
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.0226 0.0081
Entamoeba histolytica aldose reductase, putative 0.0291 0.5107 1
Leishmania major hypothetical protein, conserved 0.0013 0.0066 0.0129
Trypanosoma brucei Calpain-like protein 1.1 0.0013 0.0066 0.0129
Entamoeba histolytica calpain large subunit domain III containing protein 0.0029 0.0368 0.0599
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.0226 0.0081
Onchocerca volvulus 0.0291 0.5107 1
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0715 0.0796
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0013 0.0066 0.0129
Brugia malayi Cytochrome P450 family protein 0.0021 0.0226 0.0411
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0096 0.1571 0.177
Onchocerca volvulus 0.0291 0.5107 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0418 0.0471
Trichomonas vaginalis aldo-keto reductase, putative 0.0267 0.4685 0.9162
Trichomonas vaginalis aldo-keto reductase, putative 0.0291 0.5107 1
Onchocerca volvulus 0.0035 0.0467 0.076
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0127 0.011
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0954 0.1869
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0595 0.1166

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.374 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4581 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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