Detailed information for compound 1420944

Basic information

Technical information
  • TDR Targets ID: 1420944
  • Name: N-[1-(cyclohexylamino)-2-methyl-1-oxopropan-2 -yl]-N'-(5-methyl-1,2-oxazol-3-yl)-N-(thiophe n-2-ylmethyl)butanediamide
  • MW: 460.59 | Formula: C23H32N4O4S
  • H donors: 2 H acceptors: 4 LogP: 2.6 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1noc(c1)C)CCC(=O)N(C(C(=O)NC1CCCCC1)(C)C)Cc1cccs1
  • InChi: 1S/C23H32N4O4S/c1-16-14-19(26-31-16)25-20(28)11-12-21(29)27(15-18-10-7-13-32-18)23(2,3)22(30)24-17-8-5-4-6-9-17/h7,10,13-14,17H,4-6,8-9,11-12,15H2,1-3H3,(H,24,30)(H,25,26,28)
  • InChiKey: LXPNPHHQYXUIAV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(cyclohexylamino)-1,1-dimethyl-2-oxo-ethyl]-N'-(5-methylisoxazol-3-yl)-N-(2-thienylmethyl)butanediamide
  • N-[2-(cyclohexylamino)-1,1-dimethyl-2-oxoethyl]-N'-(5-methyl-3-isoxazolyl)-N-(2-thienylmethyl)butanediamide
  • N-[2-(cyclohexylamino)-2-keto-1,1-dimethyl-ethyl]-N'-(5-methylisoxazol-3-yl)-N-(2-thienylmethyl)succinamide
  • N-[1-(cyclohexylamino)-2-methyl-1-oxo-propan-2-yl]-N'-(5-methyl-1,2-oxazol-3-yl)-N-(thiophen-2-ylmethyl)butanediamide
  • BAS 06264722

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0042 0.1236
Schistosoma mansoni ran 0.0026 0.0023 0.0126
Onchocerca volvulus 0.018 0.0337 0.1767
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0003 0.0031
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0346
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0215 0.1271
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0039 0.0051 0.0293
Schistosoma mansoni steroid hormone receptor ad4bp 0.0091 0.0156 0.0917
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0091 0.0156 0.093
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0048 0.0748
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.093
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0005 0.001
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0039 0.0051 0.0267
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0029
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0007 0.0208
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0025 0.0138
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0694 0.1384 0.8268
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0023 0.1696
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0048 0.0068 0.0397
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0055 0.1595
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0018 0.0016
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.162 0.327 1
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0055
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0074 0.2195
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0027 0.0025 0.0742
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.0122 0.0641
Leishmania major hypothetical protein, conserved 0.0015 0.0002 0.0055
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0052 0.005
Brugia malayi Bromodomain containing protein 0.0032 0.0036 0.0217
Loa Loa (eye worm) hypothetical protein 0.018 0.0337 0.2016
Brugia malayi hypothetical protein 0.0076 0.0127 0.0756
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0091 0.0156 0.093
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0055
Onchocerca volvulus 0.0017 0.0005 0.0028
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0733 0.1464 0.8714
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0005 0.0032
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0027 0.0025 0.0131
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0018 0.0008 0.0043
Loa Loa (eye worm) hypothetical protein 0.0132 0.024 0.1436
Loa Loa (eye worm) RNA binding protein 0.0268 0.0516 0.3083
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0039 0.0051 0.0798
Echinococcus multilocularis GPCR, family 2 0.0128 0.0231 0.0229
Onchocerca volvulus 0.01 0.0175 0.0917
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0403 0.0792 0.473
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0003 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0127 1
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0004 0.0113
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.0324 0.0322
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.0122 0.0641
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0091 0.0156 0.0917
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0157
Loa Loa (eye worm) hypothetical protein 0.018 0.0337 0.2016
Schistosoma mansoni tar DNA-binding protein 0.0268 0.0516 0.3065
Loa Loa (eye worm) hypothetical protein 0.0403 0.0792 0.473
Echinococcus granulosus Dipeptidyl peptidase 9 0.0113 0.0201 0.0965
Schistosoma mansoni thyroid hormone receptor 0.0091 0.0156 0.0917
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0018 0.0016
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0018 0.0541
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0329 0.064 0.0638
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0005 0.0032
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0018 0.0008 0.0048
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0055 0.029
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0018 0.0541
Loa Loa (eye worm) nuclear receptor NHR-67 0.0043 0.0058 0.0346
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0091 0.0156 0.0745
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Mycobacterium ulcerans beta-lactamase 0.018 0.0337 0.1012
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0005 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0018 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0021 0.0108
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0027 0.0025 0.0742
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0127 0.3716
Echinococcus granulosus FTZ F1 alpha 0.0091 0.0156 0.0745
Onchocerca volvulus 0.0018 0.0008 0.0043
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0055 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0025 0.0742
Mycobacterium ulcerans TetR family transcriptional regulator 0.162 0.327 1
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0025 0.1892
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0018 0.0109
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0005
Trypanosoma cruzi mitochondrial protein 99, putative 0.0015 0.0002 0.0055
Echinococcus multilocularis cysteine protease 0.0017 0.0005 0.0003
Echinococcus multilocularis cysteine protease 0.0017 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0068 0.0409
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0048 0.1419
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0091 0.0156 0.093
Echinococcus multilocularis geminin 0.0839 0.168 0.1678
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.0337 1
Trypanosoma brucei hypothetical protein, conserved 0.018 0.0337 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0042
Trypanosoma cruzi oligopeptidase b 0.0027 0.0025 0.0742
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0048
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0049 0.0294
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0048 0.0068 0.0067
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0025 0.015
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0018 0.0008 0.0048
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0005 0.0157
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0029 0.0175
Giardia lamblia PHD finger protein 15 0.0029 0.0029 0.2238
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0091 0.2691
Brugia malayi latrophilin 2 splice variant baaae 0.0276 0.0532 0.3178
Trypanosoma brucei RNA editing exonuclease 2 0.0015 0.0002 0.0055
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0049 0.0258
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0019 0.0038
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0019 0.0038
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0049 0.0258
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0157
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0048 0.1419
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0018 0.0008 0.0043
Onchocerca volvulus 0.0091 0.0156 0.0815
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0005 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0049 0.1458
Onchocerca volvulus 0.0039 0.0051 0.0267
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0102 0.3029
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0023 0.0681
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0018 0.0098
Leishmania major cathepsin L-like protease 0.0065 0.0102 0.3029
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.093
Plasmodium vivax hypothetical protein, conserved 0.018 0.0337 1
Entamoeba histolytica hypothetical protein 0.0329 0.064 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0041 0.0188
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0023 0.063
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0091 0.0156 0.0154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0726 0.1449 0.8655
Brugia malayi RNA binding protein 0.0268 0.0516 0.3083
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0126 0.0124
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0074 0.0122 0.0584
Toxoplasma gondii cathepsin CPL 0.0017 0.0005 0.0103
Schistosoma mansoni nuclear receptor nhr-48 0.0043 0.0058 0.0335
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0048 0.1419
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0021 0.0609
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0043 0.0058 0.0272
Mycobacterium ulcerans transcriptional regulator 0.162 0.327 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0018 0.0008 0.0037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0042 0.0237
Mycobacterium tuberculosis Possible penicillin-binding protein 0.115 0.2313 0.7071
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0055
Loa Loa (eye worm) hypothetical protein 0.0048 0.0068 0.0409
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0023 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0039 0.0051 0.0798
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0019 0.0303
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0427 0.084 0.4059
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0025 0.015
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0074 0.0122 0.9822
Loa Loa (eye worm) hypothetical protein 0.018 0.0337 0.2016
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0329 0.064 0.3091
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0018 0.0285
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0336 0.0655 0.3166
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0042 0.0237
Echinococcus granulosus cathepsin l1 0.0017 0.0005 0.0017
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0042 0.1188
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.0058 0.0056
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0025 0.0692
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0019 0.0116
Schistosoma mansoni hypothetical protein 0.0148 0.0272 0.1612
Loa Loa (eye worm) hypothetical protein 0.012 0.0215 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0003 0.0001
Mycobacterium tuberculosis Conserved protein 0.018 0.0337 0.1027
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0068 0.0405
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0027 0.0025 0.0055
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0836 0.1674 1
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0018 0.0008 0.0048
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0113 0.0201 0.1187
Echinococcus granulosus dna polymerase kappa 0.0023 0.0018 0.008
Brugia malayi follicle stimulating hormone receptor 0.0694 0.1384 0.8268
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0019 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0268 0.0516 0.3065
Schistosoma mansoni GTP-binding protein alpha subunit 0.0018 0.0008 0.0037
Loa Loa (eye worm) hypothetical protein 0.0049 0.0071 0.0425
Giardia lamblia GTOR 0.0018 0.0007 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0128 0.0231 0.0229
Leishmania major endonuclease/exonuclease protein-like protein 0.0015 0.0002 0.0055
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.0125 0.984
Echinococcus granulosus lamin 0.0135 0.0245 0.118
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0049 0.0258
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0157
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0003 0.0085
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0032
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0025 0.0392
Brugia malayi Nuclear hormone receptor-like 1 0.0091 0.0156 0.093
Brugia malayi CCR4 0.0015 0.0002 0.0011
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0018 0.0541
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0024 0.0015
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0007 0.0208
Loa Loa (eye worm) hypothetical protein 0.018 0.0337 0.2016
Toxoplasma gondii exonuclease III APE 0.0076 0.0125 0.3657
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Echinococcus granulosus peregrin 0.0032 0.0036 0.0167
Schistosoma mansoni hypothetical protein 0.0839 0.168 1
Echinococcus granulosus expressed protein 0.0018 0.0008 0.003
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0127 0.3751
Loa Loa (eye worm) fli-1 protein 0.0234 0.0448 0.2674
Mycobacterium tuberculosis Probable lipase LipE 0.018 0.0337 0.1027
Loa Loa (eye worm) MH2 domain-containing protein 0.0375 0.0734 0.4387
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0126 0.3689
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.018 0.0337 0.1012
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0109
Schistosoma mansoni hypothetical protein 0.0128 0.0231 0.1363
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.018 0.0337 0.1027
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0258 0.1543
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0018 0.0008 0.0048
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0015 0.0002 0.0055
Echinococcus multilocularis musashi 0.0135 0.0245 0.0244
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0049 0.0294
Entamoeba histolytica hypothetical protein 0.0329 0.064 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0011
Schistosoma mansoni transcription factor LCR-F1 0.0329 0.064 0.3803
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0148 0.0272 0.1627
Entamoeba histolytica G protein alpha subunit, putative 0.0018 0.0008 0.0127
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0007 0.0025
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0126 0.0327
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0048 0.0068 0.0397
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0018 0.0008 0.0037
Leishmania major cathepsin L-like protease 0.0065 0.0102 0.3029
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0157
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0018 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.015
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0018 0.0541
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0091 0.0156 0.093
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0072 0.0216
Echinococcus multilocularis peregrin 0.0032 0.0036 0.0035
Brugia malayi Fli-1 protein 0.0234 0.0448 0.2674
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0058 0.0335
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0023 0.0136
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0005 0.0003
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0003 0.0086
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0048 0.3787
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0007 0.0208
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0003 0.0031
Echinococcus granulosus geminin 0.0839 0.168 0.8129
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0025 0.1892
Onchocerca volvulus 0.0015 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0042
Echinococcus granulosus jumonji domain containing protein 0.004 0.0052 0.0244
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.0337 0.1767
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0015 0.0002 0.0055
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0025 0.0138
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0126 0.3689
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0018 0.0008 0.003
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0023 0.0681
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0058 0.0272
Mycobacterium tuberculosis Probable conserved lipoprotein 0.018 0.0337 0.1027
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0076 0.0125 0.0744
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0019 0.0038
Brugia malayi MH2 domain containing protein 0.0375 0.0734 0.4387
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0018 0.0008 0.0006
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0005 0.0028
Brugia malayi hypothetical protein 0.0171 0.0319 0.1906
Echinococcus multilocularis beta LACTamase domain containing family member 0.018 0.0337 0.0336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Plasmodium falciparum phd finger protein, putative 0.0029 0.0029 0.2202
Brugia malayi ecdysteroid receptor 0.0091 0.0156 0.093
Echinococcus granulosus lamin dm0 0.0135 0.0245 0.118
Echinococcus multilocularis snurportin 1 0.0372 0.0728 0.0726
Brugia malayi hypothetical protein 0.0048 0.0068 0.0409
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0021 0.0019
Echinococcus granulosus lysosomal alpha glucosidase 0.0173 0.0324 0.1561
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0091 0.0156 0.0745
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0091 0.0156 0.0745
Brugia malayi Serine carboxypeptidase S28 family protein 0.0039 0.0051 0.0305
Loa Loa (eye worm) hypothetical protein 0.0171 0.0319 0.1906
Schistosoma mansoni nuclear hormone receptor 0.0091 0.0156 0.0917
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0007 0.0422
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0049 0.0769
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0128 0.0231 0.1108
Mycobacterium leprae Probable lipase LipE 0.018 0.0337 0.0978
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.012 0.0215 0.0213
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.0058 0.0272
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0015 0.0002 0.0055
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0092 0.0547
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0005 0.0028
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0126 0.0738
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0023 0.0681
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.3029
Loa Loa (eye worm) nuclear hormone receptor 0.0043 0.0058 0.0346
Schistosoma mansoni GTP-binding protein alpha subunit 0.0018 0.0008 0.0037
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Schistosoma mansoni hypothetical protein 0.0128 0.0231 0.1363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Loa Loa (eye worm) hypothetical protein 0.0039 0.0051 0.0305
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0048
Echinococcus multilocularis nuclear receptor nhr 48 0.0043 0.0058 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0091 0.0156 0.093
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0029 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0011
Brugia malayi TAR-binding protein 0.0268 0.0516 0.3083
Schistosoma mansoni alpha-glucosidase 0.0149 0.0275 0.1627
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0058 0.0056
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0015 0.0002 0.0055
Loa Loa (eye worm) hypothetical protein 0.0074 0.0122 0.0731
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018 0.0008 0.0037
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0055
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0128 0.0231 0.1377
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.0058 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Brugia malayi beta-lactamase family protein 0.018 0.0337 0.2016
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0091 0.0156 0.0917
Brugia malayi Steroid receptor seven-up type 2 0.0091 0.0156 0.093
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.0125 0.0652
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0113 0.0201 0.0199
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0023 0.0021
Trypanosoma brucei oligopeptidase b 0.0027 0.0025 0.0742
Echinococcus multilocularis expressed protein 0.0018 0.0008 0.0006
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0336 0.0655 0.3432
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.012 0.0215 0.6354
Loa Loa (eye worm) hypothetical protein 0.0066 0.0105 0.0628
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0015 0.0002 0.0011
Echinococcus granulosus dna polymerase eta 0.0023 0.0018 0.008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0007 0.0042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0076 0.0125 0.3691
Brugia malayi Serine protease Z688.6 precursor 0.0039 0.0051 0.0305
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.018 0.0337 0.2
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0011
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0018 0.0008 0.0037
Entamoeba histolytica hypothetical protein 0.0329 0.064 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0019 0.0054
Echinococcus multilocularis lamin dm0 0.0135 0.0245 0.0244
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0003 0.0003
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0042 0.0193
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0039 0.0051 0.1466
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0039 0.0051 0.0267
Brugia malayi hypothetical protein 0.0086 0.0147 0.0876
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.0008 0.0048
Loa Loa (eye worm) ctsf protein 0.0017 0.0005 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0049 0.0258
Schistosoma mansoni ap endonuclease 0.0076 0.0125 0.0731
Echinococcus granulosus tumor protein p63 0.1029 0.2066 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0005 0.0003
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0018 0.0096
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0049 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0091 0.0156 0.093
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0049 0.0229
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0008 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0004 0.0105
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0027 0.0025 0.0742
Echinococcus multilocularis smad 0.0026 0.0023 0.0021
Onchocerca volvulus 0.0024 0.0019 0.0102
Entamoeba histolytica hypothetical protein 0.0028 0.0028 0.0442
Schistosoma mansoni hypothetical protein 0.0276 0.0532 0.3159
Brugia malayi ecdysone receptor 0.0043 0.0058 0.0346
Schistosoma mansoni hypothetical protein 0.0839 0.168 1
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0102 0.3029
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0043 0.0058 0.0056
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0002 0.001
Trypanosoma brucei unspecified product 0.0016 0.0004 0.0105
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0043 0.0058 0.0346
Brugia malayi Cytochrome P450 family protein 0.0048 0.0068 0.0405
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0015 0.0002 0.001
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0014 0.0403
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0346
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0048 0.1372
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Brugia malayi nuclear hormone receptor family member nhr-6 0.0043 0.0058 0.0346
Brugia malayi hypothetical protein 0.0018 0.0008 0.0048
Loa Loa (eye worm) DR-78 0.0043 0.0058 0.0346
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0018 0.0034
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0126 0.3689
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0091 0.0156 0.093
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0074 0.0122 0.0718
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0028 0.0148
Brugia malayi nuclear receptor RXR 0.0048 0.0068 0.0409
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0091 0.0156 0.0154
Brugia malayi prolyl oligopeptidase family protein 0.0336 0.0655 0.3915
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0015 0.0002 0.0055
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0076 0.0125 0.3691
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0091 0.0156 0.093
Mycobacterium ulcerans AcrR family transcriptional regulator 0.162 0.327 1
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0113 0.0201 0.5955
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0427 0.084 0.4059
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0007 0.0031
Entamoeba histolytica hypothetical protein 0.0329 0.064 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0003 0.0086
Loa Loa (eye worm) fibroinase 0.0017 0.0005 0.0032
Brugia malayi Smad1 0.0026 0.0023 0.0136
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0018 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.0151 0.0277 0.1657
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0346
Schistosoma mansoni importin beta-1 0.0035 0.0042 0.0238
Loa Loa (eye worm) hypothetical protein 0.0039 0.0051 0.0305
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0102 0.3029
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0025 0.0392
Loa Loa (eye worm) hypothetical protein 0.0128 0.0231 0.1377
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Schistosoma mansoni intermediate filament proteins 0.0135 0.0245 0.1452
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0123 0.0722
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0122 0.3626
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0175
Onchocerca volvulus 0.0952 0.1909 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0007 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0048 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0074 0.0122 0.0731
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.3029
Brugia malayi nuclear hormone receptor 0.0091 0.0156 0.093
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0042 0.0249
Entamoeba histolytica cysteine protease, putative 0.0017 0.0005 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0048 0.0125
Echinococcus granulosus prolyl endopeptidase 0.0027 0.0025 0.0112
Brugia malayi intermediate filament protein 0.0135 0.0245 0.1466
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.0011
Brugia malayi hypothetical protein 0.0329 0.064 0.3823
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0018 0.005
Loa Loa (eye worm) steroid hormone receptor 0.0091 0.0156 0.093
Brugia malayi Inositol-1 0.0038 0.0048 0.0286
Schistosoma mansoni alpha-glucosidase 0.0149 0.0275 0.1627
Leishmania major cathepsin L-like protease 0.0017 0.0005 0.0157
Brugia malayi Probable ClpP-like protease 0.0076 0.0126 0.075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0072 0.0163
Echinococcus multilocularis acylamino acid releasing enzyme 0.0027 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0346
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0018 0.0008 0.0006
Onchocerca volvulus 0.0018 0.0008 0.0043
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0025 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0122 0.0641
Brugia malayi RNA recognition motif domain containing protein 0.0268 0.0516 0.3083
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0043 0.0058 0.0335
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0018 0.0008 0.0037
Onchocerca volvulus 0.0148 0.0272 0.1426
Leishmania major RNA-editing complex protein MP100, putative 0.0015 0.0002 0.0055
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0019 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Giardia lamblia DINP protein human, muc B family 0.0023 0.0018 0.1338
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0039 0.0051 0.0798
Schistosoma mansoni lamin 0.0135 0.0245 0.1452
Schistosoma mansoni coup transcription factor 0.0091 0.0156 0.0917
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0018 0.0098
Echinococcus multilocularis microtubule associated protein 2 0.0697 0.139 0.1388
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0018 0.0008 0.0037
Schistosoma mansoni thyroid hormone receptor 0.0091 0.0156 0.0917
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0019 0.0575
Brugia malayi jmjC domain containing protein 0.0035 0.0042 0.0249
Echinococcus granulosus nuclear receptor nhr 48 0.0043 0.0058 0.0272
Schistosoma mansoni cellular tumor antigen P53 0.0151 0.0277 0.1643
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0276 0.0532 0.3178
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0346
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018 0.0008 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0023 0.0125
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0018 0.0008 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0005 0.0021
Plasmodium vivax vivapain-2 0.0017 0.0005 0.0103
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0072 0.0118 0.0704
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0091 0.0156 0.093
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.0058 0.0304
Brugia malayi PHD-finger family protein 0.0029 0.0029 0.0175
Brugia malayi nuclear hormone receptor 0.0043 0.0058 0.0346
Brugia malayi Nuclear hormone receptor E75 0.0043 0.0058 0.0346
Schistosoma mansoni RAR-like nuclear receptor 0.0091 0.0156 0.0917
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.012 0.0215 0.0213
Schistosoma mansoni ap endonuclease 0.0076 0.0125 0.0731
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Mycobacterium tuberculosis Probable lipase LipD 0.018 0.0337 0.1027
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0427 0.084 0.5016
Onchocerca volvulus 0.0017 0.0005 0.0028
Onchocerca volvulus 0.0043 0.0058 0.0304
Schistosoma mansoni DNA polymerase eta 0.0023 0.0018 0.0098
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0268 0.0516 0.3083
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0091 0.0156 0.093
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.018 0.0337 0.2016
Onchocerca volvulus 0.0017 0.0005 0.0028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.018 0.0337 0.2
Echinococcus granulosus importin subunit beta 1 0.0035 0.0042 0.0193
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0007 0.0208
Schistosoma mansoni gabp alpha 0.0077 0.0128 0.0751
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.018 0.0337 0.1027
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0065 0.0103 0.0102
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.0125 0.3657
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0346
Schistosoma mansoni retinoic acid receptor RXR 0.0091 0.0156 0.0917
Brugia malayi MH1 domain containing protein 0.0026 0.0023 0.0136
Echinococcus granulosus acylamino acid releasing enzyme 0.0027 0.0025 0.0112
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0127 0.3716
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0019 0.0038
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0081
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.0011
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0027 0.0025 0.0017
Brugia malayi nuclear receptor NHR-67 0.0043 0.0058 0.0346
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0018 0.0008 0.0043
Brugia malayi conserved hypotetical protein 0.0043 0.0058 0.0346
Onchocerca volvulus 0.0017 0.0005 0.0028
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0048 0.0068 0.0323
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0024 0.1802
Onchocerca volvulus Prolyl endopeptidase homolog 0.0027 0.0025 0.0131
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.0008 0.0048
Echinococcus granulosus histone lysine methyltransferase setb 0.012 0.0215 0.1033
Mycobacterium leprae conserved hypothetical protein 0.018 0.0337 0.0978
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0427 0.084 0.5016
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0018 0.0008 0.0048
Onchocerca volvulus 0.0135 0.0245 0.1286
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0029 0.0818
Onchocerca volvulus Bile acid receptor homolog 0.0091 0.0156 0.0815
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0049 0.0258
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0003 0.0017
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0023 0.0021
Brugia malayi nuclear receptor NHR-88 0.0043 0.0058 0.0346
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0128 0.0231 0.1108
Plasmodium falciparum importin beta, putative 0.0035 0.0042 0.3197
Loa Loa (eye worm) hypothetical protein 0.0076 0.0126 0.075
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.093
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0004 0.0105
Brugia malayi Nuclear hormone receptor E75 0.0043 0.0058 0.0346
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0126 0.06
Onchocerca volvulus 0.0015 0.0002 0.001
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0025 0.0392
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.004 0.0116
Leishmania major hypothetical protein, conserved 0.0076 0.0127 0.3751
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0162 0.0778
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0007 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0005 0.0083
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0002 0.0055
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0116
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0021 0.0091
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0003 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0091 0.0156 0.093
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0208
Echinococcus multilocularis tumor protein p63 0.1029 0.2066 0.2064
Brugia malayi exodeoxyribonuclease III family protein 0.0076 0.0125 0.0744
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0025 0.0392
Loa Loa (eye worm) hypothetical protein 0.0121 0.0216 0.1292
Loa Loa (eye worm) TAR-binding protein 0.0268 0.0516 0.3083
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0048 0.0046
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0005 0.0028
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0048 0.0251
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0008 0.0043
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0018 0.0008 0.0006
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0728 0.4348
Schistosoma mansoni microtubule-associated protein tau 0.0697 0.139 0.8271
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0091 0.0156 0.0745
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0005 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0091 0.0156 0.0154
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0208
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0007 0.0208
Mycobacterium ulcerans hypothetical protein 0.0024 0.0019 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.3029
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0086
Schistosoma mansoni survival motor neuron protein 0.0148 0.0272 0.1612
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.3029
Mycobacterium tuberculosis Conserved protein 0.018 0.0337 0.1027
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Trichomonas vaginalis set domain proteins, putative 0.0952 0.1909 1
Brugia malayi beta-lactamase 0.018 0.0337 0.2016
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0015 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0346
Schistosoma mansoni hypothetical protein 0.0034 0.0041 0.0231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0007 0.0016
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0015 0.0002 0.0029
Onchocerca volvulus Protein ultraspiracle homolog 0.0091 0.0156 0.0815
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0091 0.0156 0.093
Brugia malayi Ets-domain containing protein 0.0077 0.0128 0.0764
Brugia malayi Importin beta-1 subunit 0.0035 0.0042 0.0249
Toxoplasma gondii hypothetical protein 0.0026 0.0024 0.0665
Mycobacterium ulcerans hypothetical protein 0.018 0.0337 0.1012
Leishmania major cathepsin L-like protease 0.0065 0.0102 0.3029
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0403 0.0792 0.473
Trichomonas vaginalis penicillin-binding protein, putative 0.018 0.0337 0.1767
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0346
Echinococcus multilocularis lamin 0.0135 0.0245 0.0244
Echinococcus granulosus GPCR family 2 0.0128 0.0231 0.1108
Trypanosoma brucei glucosidase, putative 0.0038 0.0049 0.1458
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0007 0.0208
Echinococcus granulosus smad 0.0026 0.0023 0.0102
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0005 0.001
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.025 0.1204
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0127 0.3751
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0733 0.1464 0.7084
Trichomonas vaginalis esterase, putative 0.018 0.0337 0.1767
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.093
Entamoeba histolytica hypothetical protein 0.0024 0.0021 0.0321
Brugia malayi Pre-SET motif family protein 0.0836 0.1674 1
Echinococcus granulosus snurportin 1 0.0372 0.0728 0.3517
Echinococcus granulosus beta LACTamase domain containing family member 0.018 0.0337 0.1626
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0049 0.0258
Onchocerca volvulus Putative neutral sphingomyelinase 0.0015 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0086 0.0147 0.0876
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0074 0.0122 0.0121
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0076 0.0125 0.036
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.093
Brugia malayi nuclear hormone receptor family member odr-7 0.0043 0.0058 0.0346
Schistosoma mansoni tar DNA-binding protein 0.0268 0.0516 0.3065
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0336 0.0655 0.3895
Brugia malayi cytoplasmic intermediate filament protein 0.0072 0.0118 0.0704
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0018 0.0008 0.0048
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0024 0.1788
Echinococcus multilocularis prolyl endopeptidase 0.0027 0.0025 0.0023
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0023 0.063
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0077 0.0128 0.0764
Loa Loa (eye worm) hypothetical protein 0.0048 0.0068 0.0409
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0091 0.0156 0.093
Loa Loa (eye worm) latrophilin receptor protein 2 0.0128 0.0231 0.1377
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0074 0.0122 0.0718
Loa Loa (eye worm) hypothetical protein 0.018 0.0337 0.2016
Echinococcus multilocularis dna polymerase eta 0.0023 0.0018 0.0016
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0055
Mycobacterium tuberculosis Probable hydrolase 0.018 0.0337 0.1027
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0039 0.0051 0.1513
Brugia malayi Serine protease Z688.6 precursor 0.0039 0.0051 0.0305
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0162 0.0161
Loa Loa (eye worm) transcription factor SMAD2 0.0375 0.0734 0.4387
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0076 0.0125 0.0595
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0427 0.084 0.4993
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0102 0.3029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.3029
Trichomonas vaginalis ran, putative 0.0026 0.0023 0.012
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0039 0.0051 0.0049
Onchocerca volvulus 0.0018 0.0008 0.0043
Brugia malayi G-protein alpha subunit 0.0018 0.0008 0.0048
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0007 0.0208
Loa Loa (eye worm) hypothetical protein 0.0039 0.0051 0.0305
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0048 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Leishmania major GTP-binding protein, putative 0.0026 0.0023 0.0681
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.004 0.0063
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0113 0.0201 0.5955
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0005 0.0083
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0007 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0091 0.0156 0.093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.3029
Loa Loa (eye worm) G protein alpha subunit 3 0.0018 0.0008 0.0048
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0007 0.0154
Trichomonas vaginalis Phospholipase C precursor, putative 0.0015 0.0002 0.001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0249
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0042
Loa Loa (eye worm) hypothetical protein 0.0076 0.0127 0.0756
Echinococcus granulosus ubiquitin specific protease 41 0.0074 0.0122 0.0584
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0019 0.0116
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0091 0.0156 0.0154
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0015 0.0002 0.0029
Echinococcus granulosus GA binding protein alpha chain 0.0077 0.0128 0.061
Giardia lamblia Serine peptidase, putative 0.0039 0.0051 0.4009
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0074 0.0122 0.0584
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.3029
Echinococcus granulosus microtubule associated protein 2 0.0697 0.139 0.6724
Schistosoma mansoni hypothetical protein 0.0128 0.0231 0.1363
Loa Loa (eye worm) beta-lactamase 0.018 0.0337 0.2016
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.0058 0.0272
Plasmodium falciparum peptidase, putative 0.0027 0.0025 0.1861
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0005 0.0277
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0011
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0018 0.0034
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0042 0.004
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0018 0.0008 0.0043
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0076 0.0125 0.3691
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0029
Onchocerca volvulus 0.018 0.0337 0.1767
Onchocerca volvulus 0.0017 0.0005 0.0028
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0055 0.0259
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0005 0.001
Trypanosoma brucei unspecified product 0.0016 0.0004 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Brugia malayi photoreceptor-specific nuclear receptor 0.0091 0.0156 0.093
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0007 0.0042
Brugia malayi hypothetical protein 0.0043 0.0058 0.0346
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0027 0.0025 0.0071
Brugia malayi nuclear receptor RXR 0.0043 0.0058 0.0346
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0018 0.0109
Leishmania major importin beta-1 subunit, putative 0.0028 0.0028 0.0839
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0126 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.3029
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0018 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0427 0.084 0.4993
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0055
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0091 0.0156 0.0745
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.0011
Brugia malayi tailless protein 0.0043 0.0058 0.0346
Echinococcus multilocularis Smad4 0.0026 0.0023 0.0021
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0007 0.0208
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0018 0.0008 0.0037
Brugia malayi nuclear receptor NHR-88 0.0091 0.0156 0.093
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0028 0.0148
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0076 0.0125 0.1947
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0039 0.0051 0.1513
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.3029
Echinococcus granulosus intermediate filament protein 0.0135 0.0245 0.118
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0113 0.0201 0.5955
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0346
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0208
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0116
Entamoeba histolytica Ran family GTPase 0.0026 0.0023 0.0359
Schistosoma mansoni inositol monophosphatase 0.0038 0.0048 0.0274
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Giardia lamblia Thymus-specific serine protease precursor 0.0039 0.0051 0.4009
Echinococcus multilocularis thyroid hormone receptor alpha 0.0091 0.0156 0.0154
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0091 0.0156 0.0154
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0025 0.015
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0018 0.0008 0.0006
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0049 0.1458
Loa Loa (eye worm) acetyltransferase 0.0141 0.0258 0.1543
Leishmania major oligopeptidase b 0.0027 0.0025 0.0742
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0027 0.0025 0.0692
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0086
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0019 0.0038
Brugia malayi hypothetical protein 0.0121 0.0216 0.1292
Brugia malayi isocitrate dehydrogenase 0.0016 0.0003 0.0017
Brugia malayi steroid hormone receptor 0.0091 0.0156 0.093
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0003 0.0017
Schistosoma mansoni alpha glucosidase 0.0038 0.0049 0.0282
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0076 0.0125 0.9862
Toxoplasma gondii prolyl endopeptidase 0.0027 0.0025 0.0692
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0005 0.0003
Onchocerca volvulus 0.018 0.0337 0.1767
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0024 0.0665
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0004 0.0113
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0015 0.0002 0.0055
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0019 0.0303
Brugia malayi Latrophilin receptor protein 2 0.0128 0.0231 0.1377
Schistosoma mansoni ets-related 0.0234 0.0448 0.2657
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0015 0.0002 0.0055
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0027 0.0025 0.0742
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0091 0.0156 0.093
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.0337 0.1767
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0091 0.0156 0.093
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0126 0.0363
Echinococcus granulosus tar DNA binding protein 0.0268 0.0516 0.2492
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0018 0.0096
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0122 0.3626
Schistosoma mansoni tar DNA-binding protein 0.0268 0.0516 0.3065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus multilocularis survival motor neuron protein 1 0.0726 0.1449 0.1447
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0018 0.0008 0.0037
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0018 0.0541
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0215 0.1271
Echinococcus multilocularis ubiquitin specific protease 41 0.0074 0.0122 0.0121
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0076 0.0125 0.3691
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0091 0.0156 0.0745
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0005 0.0277
Mycobacterium ulcerans lipase LipD 0.018 0.0337 0.1012
Brugia malayi hypothetical protein 0.0043 0.0058 0.0346
Schistosoma mansoni Smad4 0.0026 0.0023 0.0125
Plasmodium vivax importin-beta 2, putative 0.0035 0.0042 0.1188
Echinococcus granulosus thyroid hormone receptor alpha 0.0043 0.0058 0.0272
Leishmania major hypothetical protein, conserved 0.0015 0.0002 0.0055
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0002 0.0055
Trypanosoma cruzi mitochondrial protein 99, putative 0.0015 0.0002 0.0055
Schistosoma mansoni lamin 0.0135 0.0245 0.1452
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0005 0.001
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Brugia malayi MH1 domain containing protein 0.0026 0.0023 0.0136
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0074 0.0122 0.0121
Onchocerca volvulus 0.0135 0.0245 0.1286
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0051 0.0267
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0048 0.1419
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0043 0.0058 0.0335
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.3029
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0008 0.0043
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0091 0.0156 0.0745
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.162 0.327 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0051 0.0305
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.0058 0.0056
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0048 0.3726
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0018 0.0008 0.0048
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0023 0.0102
Leishmania major DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0007 0.0005
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0019 0.0038
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Onchocerca volvulus 0.0151 0.0277 0.1453
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0122 0.3626
Leishmania major hypothetical protein, conserved 0.0015 0.0002 0.0055
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Onchocerca volvulus Alhambra homolog 0.0029 0.0029 0.0153
Echinococcus multilocularis FTZ F1 alpha 0.0091 0.0156 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0007 0.0208
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0011
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0007 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.012 0.0215 0.1271
Toxoplasma gondii hypothetical protein 0.0027 0.0025 0.0692
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0091 0.0156 0.093
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0048 0.0755
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0027 0.0025 0.0131
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0018 0.0008 0.0037
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0003 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.0011
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0127 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0173 0.0324 0.1936
Schistosoma mansoni inositol monophosphatase 0.0038 0.0048 0.0274
Plasmodium vivax SET domain protein, putative 0.012 0.0215 0.6354
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0072 0.0341
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0032
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0005 0.0277
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0029 0.0164
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0049 0.0258
Brugia malayi RNA, U transporter 1 0.0099 0.0172 0.103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0025 0.0742
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0051 0.0267
Trichomonas vaginalis penicillin-binding protein, putative 0.018 0.0337 0.1767
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0015 0.0002 0.0055
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0116 0.0206 0.099
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0029 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0025 0.0131
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0021 0.0558
Trypanosoma brucei unspecified product 0.0023 0.0018 0.0541
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0025 0.015
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.015
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0029
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0065 0.0103 0.0492
Echinococcus granulosus Smad4 0.0026 0.0023 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0029 0.0818
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0032
Loa Loa (eye worm) hypothetical protein 0.0121 0.0216 0.1292
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0128 0.0231 0.0229
Loa Loa (eye worm) hypothetical protein 0.0048 0.0068 0.0409
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0102 0.3029
Brugia malayi hypothetical protein 0.0726 0.1449 0.8655
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0018 0.0008 0.0048
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0049 0.0769
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0018 0.0008 0.0043
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0018 0.0008 0.0006
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0011
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0055 0.1595
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0039 0.0051 0.1513
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.0068 0.0409
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0018 0.0109
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0019 0.0038
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0011
Plasmodium vivax vivapain-2 0.0017 0.0005 0.0103
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0091 0.0156 0.0917
Onchocerca volvulus Huntingtin homolog 0.0121 0.0216 0.1132
Schistosoma mansoni nuclear receptor 0.0043 0.0058 0.0335
Echinococcus granulosus survival motor neuron protein 1 0.0726 0.1449 0.7011
Schistosoma mansoni smad1 5 8 and 0.0026 0.0023 0.0125
Mycobacterium tuberculosis Probable peptidase 0.0027 0.0025 0.0071
Loa Loa (eye worm) hypothetical protein 0.018 0.0337 0.2016
Schistosoma mansoni hypothetical protein 0.0329 0.064 0.3803
Schistosoma mansoni smad 0.0026 0.0023 0.0125
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0002 0.001
Trypanosoma cruzi prolyl endopeptidase 0.0027 0.0025 0.0742
Onchocerca volvulus 0.0171 0.0319 0.1671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0001
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0021 0.0112
Loa Loa (eye worm) Smad1 0.0026 0.0023 0.0136
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0173 0.0324 0.1936
Onchocerca volvulus 0.0017 0.0005 0.0028
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0049 0.1458
Brugia malayi orphan nuclear receptor NR2E1 0.0043 0.0058 0.0346
Schistosoma mansoni ran 0.0026 0.0023 0.0126
Schistosoma mansoni smad1 5 8 and 0.0026 0.0023 0.0125
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0055
Schistosoma mansoni tar DNA-binding protein 0.0268 0.0516 0.3065
Brugia malayi Pre-SET motif family protein 0.012 0.0215 0.1285
Onchocerca volvulus 0.012 0.0215 0.1127
Schistosoma mansoni smad1 5 8 and 0.0026 0.0023 0.0125
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0023 0.0102
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0027 0.0025 0.0742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Brugia malayi MH2 domain containing protein 0.0026 0.0023 0.0136
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0074 0.0122 0.3626
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0048 0.0068 0.0409
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.0337 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0049 0.1411
Trypanosoma brucei prolyl endopeptidase 0.0027 0.0025 0.0742
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0091 0.0156 0.0815
Schistosoma mansoni hypothetical protein 0.0128 0.0231 0.1363
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0039 0.0051 0.0238
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0258 0.1529
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.0002 0.0029
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Treponema pallidum exodeoxyribonuclease (exoA) 0.0076 0.0125 0.9913
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0208
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0048
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0023 0.0137
Brugia malayi beta-lactamase family protein 0.018 0.0337 0.2016
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0113 0.0201 0.5955
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0346
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0076 0.0125 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.018 0.0337 0.2016
Loa Loa (eye worm) inositol-1 0.0038 0.0048 0.0286
Onchocerca volvulus 0.0017 0.0005 0.0028
Onchocerca volvulus 0.0043 0.0058 0.0304
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0039 0.0051 0.0267
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0048 0.0251
Leishmania major hypothetical protein, conserved 0.018 0.0337 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0427 0.084 0.0838
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0091 0.0156 0.093
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0015 0.0002 0.001
Trypanosoma cruzi oligopeptidase b 0.0027 0.0025 0.0742
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0091 0.0156 0.0154
Loa Loa (eye worm) cysteine protease 0.0017 0.0005 0.0032
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0029 0.0818
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0733 0.1464 0.1462
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0007 0.0042
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0091 0.0156 0.0917
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0007 0.011
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0028 0.0839
Brugia malayi prolyl oligopeptidase family protein 0.0113 0.0201 0.12
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0113 0.0201 0.5955
Trypanosoma brucei prolyl oligopeptidase, putative 0.0027 0.0025 0.0742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.0337 0.1767
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0126 1
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0015 0.0002 0.0029
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0126 0.0363
Echinococcus granulosus ecdysone induced protein 78C 0.0091 0.0156 0.0745
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0127 0.3751
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0049 0.0258
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0023 0.0021
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0028 0.0148
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0086
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0007 0.0208
Brugia malayi Calcitonin receptor-like protein seb-1 0.0403 0.0792 0.473
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0007 0.021
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0126 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.0324 0.0322
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0021 0.0123
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0015 0.0002 0.0055
Schistosoma mansoni nuclear receptor 0.0043 0.0058 0.0335
Brugia malayi hypothetical protein 0.0048 0.0068 0.0409
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0043 0.0058 0.0346
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0023 0.0136
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0126 0.9926
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0002 0.0011
Onchocerca volvulus 0.0019 0.0009 0.0048
Loa Loa (eye worm) hypothetical protein 0.0024 0.0019 0.0116
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0032
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0007 0.0208
Echinococcus multilocularis ecdysone induced protein 78C 0.0091 0.0156 0.0154
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0005 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0258 0.0257
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0346
Schistosoma mansoni hypothetical protein 0.0372 0.0728 0.4327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0019 0.0575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0091 0.0156 0.093
Loa Loa (eye worm) hypothetical protein 0.0027 0.0025 0.015
Brugia malayi jmjC domain containing protein 0.0094 0.0162 0.097
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0018 0.0008 0.0048
Schistosoma mansoni hypothetical protein 0.0029 0.0029 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Echinococcus multilocularis tar DNA binding protein 0.0268 0.0516 0.0514
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0025 0.0392
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0002 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0541
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0005 0.0028
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.093
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0004 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Leishmania major DNA polymerase eta, putative 0.0023 0.0018 0.0541
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0039 0.0051 0.0267
Echinococcus multilocularis GA binding protein alpha chain 0.0077 0.0128 0.0126
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.0002 0.0029
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0042 0.1236
Loa Loa (eye worm) hypothetical protein 0.0048 0.0068 0.0409
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0005 0.0028
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0072 0.0216
Schistosoma mansoni zinc finger protein 0.0043 0.0058 0.0335
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0076 0.0125 0.0123
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0091 0.0156 0.0917
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0346
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0005 0.0157
Onchocerca volvulus Huntingtin homolog 0.0121 0.0216 0.1132
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0135 0.0245 0.1466
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0072 0.007
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0336 0.0655 0.0654
Loa Loa (eye worm) hypothetical protein 0.0091 0.0156 0.093
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0025 0.0392
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0023 0.0102
Brugia malayi MH2 domain containing protein 0.0026 0.0023 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0427 0.084 0.0838
Mycobacterium tuberculosis Probable esterase LipL 0.018 0.0337 0.1027
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0018 0.0008 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0091 0.0156 0.093
Brugia malayi Ets-domain containing protein 0.0077 0.0128 0.0764
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0055 0.1595
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0076 0.0125 0.0375
Brugia malayi hypothetical protein 0.0049 0.0071 0.0426
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0015 0.0002 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0019 0.0575
Loa Loa (eye worm) prolyl oligopeptidase 0.0336 0.0655 0.3915
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0015 0.0002 0.001
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0015 0.0002 0.0055
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0049 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0037
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0074 0.0122 0.1912
Loa Loa (eye worm) hypothetical protein 0.0063 0.0098 0.0587
Loa Loa (eye worm) hypothetical protein 0.0065 0.0103 0.0617
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0027 0.0025 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0098 0.0587
Toxoplasma gondii ABC1 family protein 0.018 0.0337 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0002 0.0011
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0018 0.0008 0.0048
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0021 0.0609
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.0125 0.0652
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0018 0.005
Mycobacterium tuberculosis Conserved protein 0.018 0.0337 0.1027
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0007 0.011
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0042
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0023 0.1723
Brugia malayi Cathepsin L-like precursor 0.0017 0.0005 0.0032
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0007 0.021
Brugia malayi Intermediate filament tail domain containing protein 0.0135 0.0245 0.1466
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0058 0.0335
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0027 0.0025 0.0742
Loa Loa (eye worm) intermediate filament protein 0.0135 0.0245 0.1466
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0018 0.0541
Loa Loa (eye worm) hypothetical protein 0.0135 0.0245 0.1466
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0019 0.0303
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0043 0.0058 0.0056
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0007 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0427 0.084 0.4993
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.0068 0.0409
Mycobacterium ulcerans esterase/lipase LipP 0.018 0.0337 0.1012
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0042 0.004
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0126 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0041 0.0039
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0015 0.0002 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.012 0.0215 0.1271
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0091 0.0156 0.0917
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0005 0.0017
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0113 0.0201 0.5933
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0005 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0011
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0005 0.0017

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2995 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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