Detailed information for compound 1435521

Basic information

Technical information
  • TDR Targets ID: 1435521
  • Name: ethyl 2-[4-[3-(5-thiophen-3-yl-1,3,4-oxadiazo l-2-yl)propanoyl]morpholin-3-yl]acetate
  • MW: 379.431 | Formula: C17H21N3O5S
  • H donors: 0 H acceptors: 4 LogP: 0.7 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CC1COCCN1C(=O)CCc1nnc(o1)c1cscc1
  • InChi: 1S/C17H21N3O5S/c1-2-24-16(22)9-13-10-23-7-6-20(13)15(21)4-3-14-18-19-17(25-14)12-5-8-26-11-12/h5,8,11,13H,2-4,6-7,9-10H2,1H3
  • InChiKey: YVLBGQLYEREUCF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[4-[3-[5-(3-thienyl)-1,3,4-oxadiazol-2-yl]propanoyl]morpholin-3-yl]acetate
  • 2-[4-[1-oxo-3-[5-(3-thienyl)-1,3,4-oxadiazol-2-yl]propyl]-3-morpholinyl]acetic acid ethyl ester
  • 2-[4-[3-[5-(3-thienyl)-1,3,4-oxadiazol-2-yl]propanoyl]morpholin-3-yl]acetic acid ethyl ester
  • ethyl 2-[4-[3-(5-thiophen-3-yl-1,3,4-oxadiazol-2-yl)propanoyl]morpholin-3-yl]ethanoate
  • MLS000733733
  • SMR000316807
  • ethyl (4-{3-[5-(3-thienyl)-1,3,4-oxadiazol-2-yl]propanoyl}morpholin-3-yl)acetate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0417 0.0818 0.4157
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0009 0.0006
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.004 0.0036 0.0039
Trichomonas vaginalis penicillin-binding protein, putative 0.0286 0.0547 0.278
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0189 0.0345 0.0343
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0285 0.0545 0.277
Loa Loa (eye worm) hypothetical protein 0.0091 0.0142 0.0139
Toxoplasma gondii hypothetical protein 0.0417 0.0818 1
Echinococcus granulosus ubiquitin specific protease 41 0.0189 0.0345 0.0343
Loa Loa (eye worm) cytochrome P450 family protein 0.0159 0.0282 0.0279
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.004 0.0036 0.0039
Echinococcus multilocularis neuropeptide receptor A26 0.0949 0.1923 0.1921
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0042 0.004 0.0409
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0417 0.0818 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.004 0.0036 0.0017
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0031 0.0029
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0285 0.0545 0.277
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0109 0.1216
Leishmania major hypothetical protein, conserved 0.0042 0.004 0.0487
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0031 0.0303
Schistosoma mansoni hypothetical protein 0.004 0.0036 0.0033
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0176 0.0317 0.3881
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0059 0.0057
Trypanosoma brucei glycerol uptake protein, putative 0.0417 0.0818 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.011 0.018 0.0403
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0031 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0059 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0189 0.0345 0.1755
Loa Loa (eye worm) hypothetical protein 0.0417 0.0818 0.0815
Trypanosoma brucei trypanothione reductase 0.0047 0.0049 0.0523
Onchocerca volvulus Huntingtin homolog 0.0128 0.0218 0.1097
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0087 0.0133 0.0278
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0285 0.0545 0.277
Leishmania major hypothetical protein, conserved 0.0076 0.0109 0.1337
Leishmania major lanosterol 14-alpha-demethylase, putative 0.004 0.0036 0.0439
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0285 0.0545 0.277
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0042 0.004 0.0355
Onchocerca volvulus 0.008 0.0119 0.0591
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0189 0.0345 0.0343
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0059 0.0057
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0118 0.0597
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0155 0.0273 0.3252
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.004 0.0036 0.0017
Echinococcus granulosus dna polymerase eta 0.0038 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.0052 0.0059 0.0057
Plasmodium falciparum thioredoxin reductase 0.0047 0.0049 0.0469
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0087 0.0133 0.013
Echinococcus granulosus microtubule associated protein 2 0.1403 0.2866 0.2864
Loa Loa (eye worm) hypothetical protein 0.0091 0.0142 0.0139
Brugia malayi Hhat protein 0.0417 0.0818 0.0815
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0125 0.0211 0.2473
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.004 0.0036 0.0017
Schistosoma mansoni hypothetical protein 0.029 0.0554 0.0551
Plasmodium falciparum GAF domain-related protein, putative 0.011 0.018 0.2088
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0008 0.0039
Brugia malayi hypothetical protein 0.0049 0.0054 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0417 0.0818 0.4157
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0059 0.0057
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0155 0.0273 0.3344
Schistosoma mansoni hypothetical protein 0.0144 0.025 0.0248
Echinococcus granulosus RUN 0.0041 0.0038 0.0035
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0417 0.0818 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0373 0.0728 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.004 0.0202
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0285 0.0545 0.0543
Loa Loa (eye worm) beta-lactamase 0.0286 0.0547 0.0544
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0285 0.0545 0.6637
Echinococcus multilocularis microtubule associated protein 2 0.1403 0.2866 0.2864
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0417 0.0818 0.0815
Schistosoma mansoni sterol O-acyltransferase 1 0.0417 0.0818 0.0815
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0031 0.0029
Echinococcus granulosus mitogen activated protein kinase 0.0155 0.0273 0.0271
Brugia malayi ecdysteroid receptor 0.0052 0.0059 0.0057
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0417 0.0818 0.0815
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0417 0.0818 1
Entamoeba histolytica hypothetical protein 0.029 0.0554 0.6773
Echinococcus multilocularis 0.004 0.0036 0.0033
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0198 0.0452
Leishmania major hypothetical protein, conserved 0.0286 0.0547 0.6686
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.004 0.0036 0.0039
Trypanosoma brucei cytochrome P450, putative 0.0059 0.0074 0.0835
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0211 0.0208
Mycobacterium ulcerans hypothetical protein 0.0159 0.0282 0.2096
Echinococcus multilocularis mitogen activated protein kinase 0.0155 0.0273 0.0271
Leishmania major hypothetical protein, conserved 0.0417 0.0818 1
Onchocerca volvulus 0.0144 0.025 0.1261
Brugia malayi follicle stimulating hormone receptor 0.1152 0.2345 0.2343
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0236 0.0443 0.0441
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0248 0.3033
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.004 0.0036 0.0039
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0039 0.0349
Loa Loa (eye worm) hypothetical protein 0.0286 0.0547 0.0544
Trichomonas vaginalis penicillin-binding protein, putative 0.0286 0.0547 0.278
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0047 0.0447
Loa Loa (eye worm) hypothetical protein 0.0189 0.0345 0.0343
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0417 0.0818 0.0815
Trichomonas vaginalis CMGC family protein kinase 0.0155 0.0273 0.139
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0006
Echinococcus granulosus neuropeptide receptor A26 0.0949 0.1923 0.1921
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0189 0.0345 0.0343
Loa Loa (eye worm) hhat protein 0.0417 0.0818 0.0815
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.004 0.0036 0.0017
Toxoplasma gondii hypothetical protein 0.0243 0.0457 0.5529
Trypanosoma brucei hypothetical protein, conserved 0.0286 0.0547 0.6659
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0042 0.004 0.0487
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0042 0.004 0.0037
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0147 0.0257 0.1893
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0286 0.0547 0.0544
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0198 0.1364
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0286 0.0547 0.0544
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0155 0.0273 0.3289
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0033 0.0407
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0059 0.0057
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0059 0.0057
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.004 0.0489
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0417 0.0818 0.0815
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0037 0.003 0.0363
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.004 0.0036 0.0017
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0285 0.0545 0.6637
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.004 0.0487
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0173 0.1156
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0049 0.0046
Schistosoma mansoni hypothetical protein 0.0304 0.0584 0.0581
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0285 0.0545 0.0543
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.004 0.0036 0.0439
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0042 0.004 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0059 0.0057
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0059 0.0057
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0031 0.0004
Brugia malayi hypothetical protein 0.0704 0.1415 0.1413
Echinococcus granulosus survival motor neuron protein 1 0.0704 0.1415 0.1413
Echinococcus multilocularis tumor protein p63 0.034 0.0658 0.0656
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0059 0.0057
Brugia malayi steroid hormone receptor 0.0052 0.0059 0.0057
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Loa Loa (eye worm) hypothetical protein 0.0704 0.1415 0.1413
Brugia malayi hypothetical protein 0.0041 0.0038 0.0035
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.0276 0.0273
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0042 0.004 0.0202
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.004 0.0487
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.4837 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0042 0.004 0.0202
Toxoplasma gondii thioredoxin reductase 0.0047 0.0049 0.0469
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0009 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.004 0.0036 0.0017
Brugia malayi MBOAT family protein 0.0417 0.0818 0.0815
Brugia malayi MBOAT family protein 0.0417 0.0818 0.0815
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0373 0.0728 0.0725
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.0052 0.0059 0.0057
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0173 0.0386
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0285 0.0545 0.277
Schistosoma mansoni microtubule-associated protein tau 0.1403 0.2866 0.2864
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0033 0.0273
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0371 0.0724 0.0721
Onchocerca volvulus 0.0052 0.0059 0.0289
Mycobacterium tuberculosis Conserved protein 0.0286 0.0547 0.1389
Brugia malayi Cytochrome P450 family protein 0.0059 0.0074 0.0072
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0087 0.0133 0.0852
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0042 0.004 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0059 0.0057
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0042 0.004 0.0037
Echinococcus multilocularis cpg binding protein 0.0125 0.0212 0.0209
Echinococcus multilocularis dnaJ subfamily B 0.1268 0.2586 0.2584
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0031 0.0029
Onchocerca volvulus 0.0286 0.0547 0.277
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0059 0.0057
Loa Loa (eye worm) hhat protein 0.0417 0.0818 0.0815
Echinococcus granulosus o acyltransferase membrane bound domain 0.0417 0.0818 0.0815
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.004 0.0036 0.0039
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0189 0.0345 0.4223
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0125 0.0211 0.0208
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0039 0.0481
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.004 0.0036 0.0017
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0087 0.0133 0.0852
Trypanosoma cruzi glycerol uptake protein, putative 0.0417 0.0818 1
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0087 0.0133 1
Echinococcus multilocularis Aminotransferase class III 0.0087 0.0133 0.013
Leishmania major DNA polymerase eta, putative 0.0038 0.0031 0.0382
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.008 0.0118 0.0597
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0059 0.0057
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0042 0.004 0.0202
Leishmania major cytochrome p450-like protein 0.0059 0.0074 0.0909
Schistosoma mansoni DNA polymerase eta 0.0038 0.0031 0.0029
Echinococcus multilocularis survival motor neuron protein 1 0.0704 0.1415 0.1413
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.004 0.0202
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.0578 0.7062
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0286 0.0547 0.1389
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0038 0.0332
Schistosoma mansoni rab6-interacting 0.0041 0.0038 0.0035
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.004 0.0036 0.0439
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0042 0.004 0.0037
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0042 0.004 0.0355
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0034 0.0022 0.002
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0033 0.0031
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.004 0.0036 0.0017
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.0196 0.0193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0059 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.004 0.0036 0.0017
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0052 0.0059 0.0057
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0059 0.0289
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0042 0.004 0.0487
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0373 0.0728 0.0725
Echinococcus granulosus dna polymerase kappa 0.0038 0.0031 0.0029
Schistosoma mansoni eyes absent homolog 0.0091 0.0142 0.0139
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.0119 0.0116
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0059 0.0057
Loa Loa (eye worm) histone methyltransferase 0.0041 0.0037 0.0035
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0042 0.004 0.0037
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0042 0.004 0.0487
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0033 0.0031
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0059 0.0057
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0155 0.0273 0.3344
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0059 0.0057
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0613 0.1225 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.004 0.0489
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0059 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0286 0.0547 0.278
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0059 0.0057
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.0276 0.0273
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0087 0.0133 0.0278
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0155 0.0273 0.3344
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0059 0.0057
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.004 0.0036 0.0039
Loa Loa (eye worm) hypothetical protein 0.0286 0.0547 0.0544
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0008 0.0039
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0031 0.0159
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0236 0.0443 0.0441
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0031 0.0303
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0042 0.004 0.0355
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0059 0.0724
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0031 0.0159
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0189 0.0345 0.1755
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.004 0.0411
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0031 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0031 0.0303
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0109 0.1216
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0059 0.0057
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.0119 0.0116
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.029 0.0554 0.0551
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0033 0.0031
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1829 0.3752 1
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0059 0.0289
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0417 0.0818 0.0815
Schistosoma mansoni hypothetical protein 0.1268 0.2586 0.2584
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0008 0.0039
Echinococcus multilocularis sterol O acyltransferase 1 0.0417 0.0818 0.0815
Trichomonas vaginalis D-aminoacylase, putative 0.0286 0.0547 0.278
Toxoplasma gondii ABC1 family protein 0.0286 0.0547 0.664
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0286 0.0547 0.0544
Mycobacterium ulcerans aldehyde dehydrogenase 0.0371 0.0724 0.58
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0059 0.0057
Trichomonas vaginalis esterase, putative 0.0286 0.0547 0.278
Schistosoma mansoni lipoxygenase 0.0109 0.0178 0.0176
Echinococcus granulosus sterol O acyltransferase 1 0.0417 0.0818 0.0815
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0049 0.06
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Brugia malayi glutathione reductase 0.0047 0.0049 0.0046
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0042 0.004 0.0355
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Leishmania major hypothetical protein, conserved 0.0042 0.004 0.0487
Loa Loa (eye worm) hypothetical protein 0.0286 0.0547 0.0544
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0417 0.0818 0.0815
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0285 0.0545 0.6664
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0042 0.004 0.0037
Echinococcus multilocularis ornithine aminotransferase 0.0087 0.0133 0.013
Trypanosoma brucei protein kinase, putative 0.0155 0.0273 0.3289
Loa Loa (eye worm) hypothetical protein 0.0076 0.0109 0.0107
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0008 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0243 0.0457 0.2324
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.0276 0.0273
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0031 0.0303
Brugia malayi Muscleblind-like protein 0.1494 0.3057 0.3055
Loa Loa (eye worm) hypothetical protein 0.0052 0.0059 0.0057
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0183 0.0333 0.033
Loa Loa (eye worm) MBOAT family protein 0.4837 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0009 0.0006
Echinococcus granulosus mitogen activated protein kinase 3 0.0155 0.0273 0.0271
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0183 0.0333 0.033
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0033 0.0407
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0059 0.0057
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0074 0.0909
Loa Loa (eye worm) hypothetical protein 0.0052 0.0059 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0286 0.0547 0.278
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0371 0.0724 0.8849
Schistosoma mansoni importin beta-1 0.0028 0.0011 0.0009
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0031 0.0382
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0047 0.0447
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0285 0.0545 0.277
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0087 0.0133 0.151
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0033 0.0273
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.0584 0.0581
Plasmodium falciparum glutathione reductase 0.0047 0.0049 0.0469
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0031 0.0382
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.036 0.07 0.0697
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.004 0.0036 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0059 0.0057
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0285 0.0545 0.277
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0008 0.0039
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0056 0.0054
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0042 0.004 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0286 0.0547 0.6686
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0031 0.0303
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0035
Echinococcus granulosus o acyltransferase membrane bound domain 0.0417 0.0818 0.0815
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0042 0.004 0.0409
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Echinococcus multilocularis beta LACTamase domain containing family member 0.0286 0.0547 0.0544
Toxoplasma gondii exonuclease III APE 0.0039 0.0033 0.0273
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0047 0.024
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0074 0.0909
Loa Loa (eye worm) acetyltransferase 0.0156 0.0276 0.0273
Trypanosoma brucei unspecified product 0.0038 0.0031 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0059 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0031 0.0382
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0038 0.0035
Treponema pallidum alginate O-acetylation protein (algI) 0.0417 0.0818 1
Echinococcus granulosus zinc finger protein 0.442 0.9134 0.9134
Echinococcus granulosus importin subunit beta 1 0.0028 0.0011 0.0009
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0033 0.0169
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0211 0.0208
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.004 0.0487
Loa Loa (eye worm) hypothetical protein 0.005 0.0056 0.0054
Mycobacterium ulcerans aldehyde dehydrogenase 0.0371 0.0724 0.58
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0042 0.004 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0189 0.0345 0.1755
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0008 0.0039
Trypanosoma cruzi glycerol uptake protein, putative 0.0417 0.0818 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0031 0.0382
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.0059 0.0057
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0189 0.0345 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0059 0.0057
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0038 0.0035
Brugia malayi hypothetical protein 0.0041 0.0038 0.0035
Toxoplasma gondii aldehyde dehydrogenase 0.0371 0.0724 0.8833
Schistosoma mansoni cytochrome P450 0.004 0.0036 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.004 0.0036 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0059 0.0057
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0176 0.0317 0.1614
Schistosoma mansoni ap endonuclease 0.0039 0.0033 0.0031
Schistosoma mansoni zinc finger protein 0.4837 1 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0417 0.0818 1
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0613 0.1225 0.3211
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0042 0.004 0.0037
Echinococcus granulosus mixed lineage leukemia protein mll 0.0034 0.0022 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.004 0.0487
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0033 0.0407
Schistosoma mansoni rab6-interacting 0.0041 0.0038 0.0035
Loa Loa (eye worm) doublecortin family protein 0.0041 0.0038 0.0035
Echinococcus granulosus neuropeptide s receptor 0.0949 0.1923 0.1921
Plasmodium vivax phosphodiesterase gamma, putative 0.0042 0.004 0.0355
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0009 0.0006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.029 0.0554 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0059 0.0057
Mycobacterium ulcerans putative regulatory protein 0.011 0.018 0.1243
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.004 0.0036 0.0039
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.0578 0.7062
Brugia malayi hypothetical protein 0.0027 0.0009 0.0006
Schistosoma mansoni cpg binding protein 0.0125 0.0212 0.0209
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0087 0.0133 0.0278
Loa Loa (eye worm) hypothetical protein 0.0052 0.0059 0.0057
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.0037
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0041 0.0037 0.0035
Plasmodium falciparum ornithine aminotransferase 0.0087 0.0133 0.151
Echinococcus granulosus muscleblind protein 0.1494 0.3057 0.3055
Loa Loa (eye worm) hypothetical protein 0.0052 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0006
Brugia malayi MBOAT family protein 0.0417 0.0818 0.0815
Brugia malayi diacylglycerol acyltransferase 0.0417 0.0818 0.0815
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0152 0.0267 0.1359
Loa Loa (eye worm) hypothetical protein 0.0286 0.0547 0.0544
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0033 0.0031
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0613 0.1225 0.6228
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0008 0.0039
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0109 0.1216
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0042 0.004 0.0037
Loa Loa (eye worm) hypothetical protein 0.0286 0.0547 0.0544
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.004 0.0036 0.0017
Toxoplasma gondii histone lysine methyltransferase SET1 0.0232 0.0435 0.5248
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0173 0.0386
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0248 0.2976
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0042 0.004 0.0037
Mycobacterium leprae conserved hypothetical protein 0.011 0.018 0.1208
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0033 0.0064
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0056 0.0054
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0042 0.004 0.0037
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.0038 0.0332
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0049 0.0469
Trichomonas vaginalis porcupine, putative 0.0417 0.0818 0.4157
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0173 0.0386
Loa Loa (eye worm) glutathione reductase 0.0047 0.0049 0.0046
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Echinococcus multilocularis neuropeptide s receptor 0.0949 0.1923 0.1921
Onchocerca volvulus 0.0118 0.0198 0.0992
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Loa Loa (eye worm) hypothetical protein 0.0128 0.0218 0.0216
Mycobacterium ulcerans putative regulatory protein 0.011 0.018 0.1243
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0031 0.0303
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0109 0.1216
Brugia malayi nuclear receptor RXR 0.0027 0.0009 0.0006
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0042 0.004 0.0037
Echinococcus granulosus cpg binding protein 0.0125 0.0212 0.0209
Leishmania major mitochondrial DNA polymerase beta 0.0301 0.0578 0.7062
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.004 0.0036 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0155 0.0273 0.139
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0087 0.0133 0.0817
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0042 0.004 0.0409
Mycobacterium tuberculosis Probable hydrolase 0.0286 0.0547 0.1389
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0155 0.0273 0.3344
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0042 0.004 0.0355
Loa Loa (eye worm) hypothetical protein 0.0236 0.0443 0.0441
Mycobacterium tuberculosis Probable aminotransferase 0.0613 0.1225 0.3211
Trypanosoma cruzi GUP1, putative 0.0417 0.0818 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.004 0.0036 0.0039
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0125 0.0211 0.0208
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0042 0.004 0.0487
Onchocerca volvulus 0.0286 0.0547 0.277
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0198 0.0452
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1152 0.2345 0.2343
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0031 0.0303
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0042 0.004 0.0409
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0008 0.0039
Brugia malayi beta-lactamase 0.0286 0.0547 0.0544
Mycobacterium tuberculosis Conserved protein 0.0286 0.0547 0.1389
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0033 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0022 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0008 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0006
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0047 0.0447
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0049 0.0046
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0417 0.0818 0.0815
Echinococcus granulosus beta LACTamase domain containing family member 0.0286 0.0547 0.0544
Brugia malayi nuclear receptor NHR-88 0.0052 0.0059 0.0057
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0042 0.004 0.0037
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0286 0.0547 0.4318
Leishmania major hypothetical protein, conserved 0.0037 0.003 0.0363
Plasmodium vivax hypothetical protein, conserved 0.011 0.018 0.2088
Echinococcus multilocularis zinc finger protein 0.442 0.9134 0.9134
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0031 0.0303
Brugia malayi RNA, U transporter 1 0.0081 0.012 0.0118
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Loa Loa (eye worm) CYP4Cod1 0.0059 0.0074 0.0072
Loa Loa (eye worm) hypothetical protein 0.0286 0.0547 0.0544
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Trichomonas vaginalis transmembrane protein nessy, putative 0.0417 0.0818 0.4157
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0042 0.004 0.0037
Loa Loa (eye worm) MBOAT family protein 0.0417 0.0818 0.0815
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0008 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0286 0.0547 0.6686
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0417 0.0818 1
Toxoplasma gondii GAF domain-containing protein 0.011 0.018 0.2088
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.004 0.0036 0.0039
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0033 0.0328
Echinococcus multilocularis ornithine aminotransferase 0.0087 0.0133 0.013
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0417 0.0818 0.0815
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.004 0.0036 0.0361
Brugia malayi Pre-SET motif family protein 0.0125 0.0211 0.0208
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.004 0.0036 0.0017
Brugia malayi nuclear hormone receptor 0.0052 0.0059 0.0057
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.0119 0.0116
Trichomonas vaginalis helicase, putative 0.0027 0.0008 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0243 0.0457 0.2324
Mycobacterium tuberculosis Probable reductase 0.0107 0.0173 0.0386
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0087 0.0133 0.0852
Echinococcus granulosus histone lysine methyltransferase setb 0.0125 0.0211 0.0208
Onchocerca volvulus 0.0417 0.0818 0.4149
Mycobacterium ulcerans L-lysine aminotransferase 0.0087 0.0133 0.0852
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0255 0.0482 0.048
Brugia malayi Doublecortin family protein 0.0041 0.0038 0.0035
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0417 0.0818 0.0815
Loa Loa (eye worm) hypothetical protein 0.0128 0.0218 0.0216
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0189 0.0345 0.4223
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.004 0.0487
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.1494 0.3057 0.3055
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0039 0.0259
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0059 0.0074 0.0361
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.0267 0.0264
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0417 0.0818 0.0815
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0417 0.0818 0.0815
Trichomonas vaginalis CMGC family protein kinase 0.0155 0.0273 0.139
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0417 0.0818 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0417 0.0818 0.0815
Loa Loa (eye worm) hypothetical protein 0.008 0.0119 0.0116
Giardia lamblia hypothetical protein 0.0042 0.004 0.0274
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0042 0.004 0.0355
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2469 0.5082 0.5081
Plasmodium vivax ornithine aminotransferase, putative 0.0087 0.0133 0.151
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0023 0.002
Leishmania major trypanothione reductase 0.0047 0.0049 0.06
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0285 0.0545 0.6664
Trichomonas vaginalis conserved hypothetical protein 0.0323 0.0623 0.3165
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0031 0.0382
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0034 0.0022 0.002
Brugia malayi hypothetical protein 0.0128 0.0218 0.0216
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0373 0.0728 0.0725
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0059 0.0289
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0371 0.0724 0.1864
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0285 0.0545 0.277
Entamoeba histolytica hypothetical protein, conserved 0.0417 0.0818 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0042 0.004 0.0037
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.0037 0.003 0.0284
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.4837 1 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.004 0.0036 0.0039
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Mycobacterium ulcerans beta-lactamase 0.0286 0.0547 0.4318
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0371 0.0724 0.0721
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0059 0.0057
Mycobacterium ulcerans hypothetical protein 0.0613 0.1225 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0417 0.0818 1
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0109 0.1266
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.0038 0.0035
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0059 0.0057
Echinococcus granulosus cytochrome P450 2K1 0.004 0.0036 0.0033
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.004 0.0036 0.0039
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0417 0.0818 0.0815
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0282 0.0677
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0006
Schistosoma mansoni polycystin 1-related 0.0041 0.0038 0.0035
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0059 0.0057
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.004 0.0036 0.0039
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.0038 0.0035
Echinococcus multilocularis snurportin 1 0.0304 0.0584 0.0581
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.004 0.0036 0.0017
Loa Loa (eye worm) hypothetical protein 0.0052 0.0059 0.0057
Giardia lamblia Hypothetical protein 0.0042 0.004 0.0274
Mycobacterium ulcerans aldehyde dehydrogenase 0.0371 0.0724 0.58
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.0125 0.0211 0.0208
Echinococcus multilocularis ubiquitin specific protease 41 0.0189 0.0345 0.0343
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.0037
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0042 0.004 0.0487
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0042 0.004 0.0037
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0248 0.3033
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0038 0.0035
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.0417 0.0818 0.0815
Loa Loa (eye worm) PDE1B protein 0.0042 0.004 0.0037
Schistosoma mansoni aldehyde dehydrogenase 0.0371 0.0724 0.0721
Leishmania major glycerol uptake protein, putative 0.0417 0.0818 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.004 0.0036 0.0306
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0198 0.0452
Mycobacterium tuberculosis Probable lipase LipE 0.0286 0.0547 0.1389
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0152 0.0267 0.1359
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0189 0.0345 1
Mycobacterium ulcerans lipase LipD 0.0286 0.0547 0.4318
Echinococcus multilocularis muscleblind protein 1 0.1494 0.3057 0.3055
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.004 0.0036 0.0017
Brugia malayi F/Y-rich N-terminus family protein 0.0041 0.0036 0.0034
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0059 0.0057
Leishmania major cytochrome p450-like protein 0.004 0.0036 0.0439
Brugia malayi Cytochrome P450 family protein 0.0059 0.0074 0.0072
Onchocerca volvulus 0.0041 0.0038 0.018
Loa Loa (eye worm) hypothetical protein 0.005 0.0055 0.0053
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.0119 0.0116
Mycobacterium ulcerans acetylornithine aminotransferase 0.0087 0.0133 0.0852
Trichomonas vaginalis conserved hypothetical protein 0.0243 0.0457 0.2324
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0285 0.0545 0.277
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0059 0.0057
Schistosoma mansoni lipoxygenase 0.0183 0.0333 0.033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0211 0.0208
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0417 0.0818 0.0815
Brugia malayi hypothetical protein 0.0076 0.0109 0.0107
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0011 0.0056
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0059 0.0057
Schistosoma mansoni cpg binding protein 0.0125 0.0212 0.0209
Mycobacterium leprae conserved hypothetical protein 0.0286 0.0547 0.4296
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0008 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.0273 0.0271
Loa Loa (eye worm) hypothetical protein 0.0034 0.0023 0.0021
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0176 0.0317 0.1614
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0189 0.0345 0.0343
Schistosoma mansoni ap endonuclease 0.0039 0.0033 0.0031
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.004 0.0036 0.0039
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0286 0.0547 0.1389
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0373 0.0728 0.0725
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0049 0.0052
Brugia malayi hypothetical protein 0.0027 0.0009 0.0006
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0417 0.0818 0.0815
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.0037
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Plasmodium falciparum phosphodiesterase gamma, putative 0.0042 0.004 0.0355
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.004 0.0036 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0031 0.0303
Echinococcus granulosus snurportin 1 0.0304 0.0584 0.0581
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.004 0.0036 0.0017
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0144 0.025 0.0248
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0042 0.004 0.0202
Trichomonas vaginalis CMGC family protein kinase 0.0155 0.0273 0.139
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0059 0.0057
Entamoeba histolytica hypothetical protein 0.029 0.0554 0.6773
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.004 0.0036 0.0017
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0059 0.0057
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0031 0.0029
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0087 0.0133 0.5
Schistosoma mansoni hypothetical protein 0.0034 0.0023 0.0021
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0031 0.0303
Brugia malayi Cytochrome P450 family protein 0.0159 0.0282 0.0279
Schistosoma mansoni hypothetical protein 0.0034 0.0023 0.002
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0155 0.0273 0.0271
Trichomonas vaginalis set domain proteins, putative 0.097 0.1967 1
Schistosoma mansoni survival motor neuron protein 0.0144 0.025 0.0248
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.004 0.0487
Echinococcus multilocularis dna polymerase eta 0.0038 0.0031 0.0029
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0055 0.0053
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Brugia malayi Importin beta-1 subunit 0.0028 0.0011 0.0009
Onchocerca volvulus 0.005 0.0055 0.0268
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.004 0.0036 0.0039
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0031 0.0029
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0087 0.0133 0.0817
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0035
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0059 0.0057
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0031 0.0004
Echinococcus multilocularis RUN 0.0041 0.0038 0.0035
Loa Loa (eye worm) CXXC zinc finger family protein 0.0118 0.0198 0.0195
Plasmodium vivax hypothetical protein, conserved 0.0286 0.0547 0.664
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0285 0.0545 0.6664
Giardia lamblia Kinase, CMGC MAPK 0.0155 0.0273 0.7712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0059 0.0057
Brugia malayi MAP kinase sur-1 0.0155 0.0273 0.0271
Schistosoma mansoni aldehyde dehydrogenase 0.0371 0.0724 0.0721
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0074 0.0072
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0285 0.0545 0.0543
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0042 0.004 0.0202
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0031 0.0303
Leishmania major DNA polymerase kappa, putative 0.0038 0.0031 0.0382
Trypanosoma cruzi cytochrome p450-like protein, putative 0.004 0.0036 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0008 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0031 0.0303
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0323 0.0623 0.3165
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0087 0.0133 0.0852
Loa Loa (eye worm) hypothetical protein 0.0318 0.0612 0.0609
Leishmania major glycerol uptake protein, putative 0.0417 0.0818 1
Schistosoma mansoni cpg binding protein 0.0118 0.0198 0.0195
Trypanosoma cruzi GUP1, putative 0.0417 0.0818 1
Onchocerca volvulus 0.0041 0.0038 0.018
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0031 0.0382
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0286 0.0547 0.0544
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0059 0.0057
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0286 0.0547 0.1389
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0059 0.0057
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0173 0.0386
Mycobacterium leprae Probable lipase LipE 0.0286 0.0547 0.4296
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0009 0.0006
Mycobacterium ulcerans esterase/lipase LipP 0.0286 0.0547 0.4318
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.004 0.0036 0.0039
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0033 0.0169
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0189 0.0345 0.0343
Leishmania major cAMP-specific phosphodiesterase, putative 0.0042 0.004 0.0487
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0059 0.0057
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0059 0.0057
Mycobacterium ulcerans hypothetical protein 0.0286 0.0547 0.4318
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.004 0.0409
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0049 0.0046
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.004 0.0036 0.0039
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0087 0.0133 0.0278
Brugia malayi beta-lactamase family protein 0.0286 0.0547 0.0544
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0033 0.0407
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0087 0.0133 0.013
Brugia malayi CXXC zinc finger family protein 0.0118 0.0198 0.0195
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0155 0.0273 0.3344
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0031 0.0029
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0056 0.0054
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0155 0.0273 0.3344
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0023 0.0021
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0417 0.0818 0.0815
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0034 0.0022 0.002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0373 0.0728 0.0725
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0301 0.0578 0.7038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0059 0.0057
Echinococcus granulosus Aminotransferase class III 0.0087 0.0133 0.013
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0059 0.0057
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0323 0.0623 0.3165
Leishmania major cytochrome p450-like protein 0.004 0.0036 0.0439
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0042 0.004 0.0037
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.004 0.0489
Leishmania major glycerol uptake protein, putative 0.0417 0.0818 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0042 0.004 0.0202
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0059 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0008 0.0039
Brugia malayi cytochrome P450 0.004 0.0036 0.0033
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.004 0.0036 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0031 0.0303
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0042 0.004 0.0202
Plasmodium vivax glutathione reductase, putative 0.0047 0.0049 0.0469
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0042 0.004 0.0037
Brugia malayi Cytochrome P450 family protein 0.004 0.0036 0.0033
Brugia malayi Pre-SET motif family protein 0.0853 0.1723 0.1721
Mycobacterium tuberculosis Conserved protein 0.0286 0.0547 0.1389
Loa Loa (eye worm) cytochrome P450 0.004 0.0036 0.0033
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Echinococcus multilocularis muscleblind protein 0.1494 0.3057 0.3055
Mycobacterium tuberculosis Probable esterase LipL 0.0286 0.0547 0.1389
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0189 0.0345 0.4223
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0008 0.0039
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Schistosoma mansoni coup transcription factor 0.0052 0.0059 0.0057
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.036 0.07 0.0697
Echinococcus granulosus tumor protein p63 0.034 0.0658 0.0656
Entamoeba histolytica hypothetical protein 0.029 0.0554 0.6773
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0047 0.0045
Onchocerca volvulus 0.0286 0.0547 0.277
Loa Loa (eye worm) hypothetical protein 0.0417 0.0818 0.0815
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0008 0.0039
Schistosoma mansoni transcription factor LCR-F1 0.029 0.0554 0.0551
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0042 0.004 0.0202
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.004 0.0036 0.0017
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.004 0.0036 0.0017
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0042 0.004 0.0037
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0041 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0009
Plasmodium falciparum phosphodiesterase delta, putative 0.0042 0.004 0.0355
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.004 0.0036 0.0039
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0031 0.0382
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0323 0.0623 0.3165
Entamoeba histolytica hypothetical protein 0.0417 0.0818 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0059 0.0057
Toxoplasma gondii hypothetical protein 0.0049 0.0053 0.0517
Toxoplasma gondii hypothetical protein 0.011 0.018 0.2088
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0047 0.024
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0042 0.004 0.0037
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0033 0.001
Onchocerca volvulus 0.0125 0.0211 0.1059
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0059 0.0057
Entamoeba histolytica hypothetical protein 0.029 0.0554 0.6773
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0613 0.1225 1
Loa Loa (eye worm) hypothetical protein 0.0417 0.0818 0.0815
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0009 0.0006
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0417 0.0818 0.0815
Trichomonas vaginalis conserved hypothetical protein 0.0417 0.0818 0.4157
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0042 0.004 0.0037
Entamoeba histolytica vacuolar protein sorting 26 0.0417 0.0818 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0042 0.004 0.0037
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0011 0.0056
Brugia malayi MBOAT family protein 0.0417 0.0818 0.0815
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0189 0.0345 0.4223
Leishmania major glycerol uptake protein, putative 0.0417 0.0818 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0109 0.1337
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0125 0.0211 0.0208
Mycobacterium tuberculosis Probable lipase LipD 0.0286 0.0547 0.1389
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0008 0.0039
Brugia malayi hypothetical protein 0.0091 0.0142 0.0139
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0417 0.0818 0.0815
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0042 0.004 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.011 0.018 0.0913
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0059 0.0057
Loa Loa (eye worm) hypothetical protein 0.0208 0.0384 0.0382
Echinococcus granulosus ornithine aminotransferase 0.0087 0.0133 0.013
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0042 0.004 0.0037
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.1494 0.3057 0.3055
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.036 0.07 0.0697
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0417 0.0818 1
Brugia malayi beta-lactamase family protein 0.0286 0.0547 0.0544
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0031 0.0029
Onchocerca volvulus 0.097 0.1967 1
Leishmania major glycerol uptake protein, putative 0.0417 0.0818 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0109 0.1337
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.0037 0.003 0.0363
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0853 0.1723 0.1721
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0031 0.0303
Brugia malayi Thioredoxin reductase 0.0047 0.0049 0.0046
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0042 0.004 0.0037
Trypanosoma brucei glycerol uptake protein, putative 0.0417 0.0818 1
Loa Loa (eye worm) MBOAT family protein 0.0417 0.0818 0.0815
Echinococcus multilocularis mitogen activated protein kinase 3 0.0155 0.0273 0.0271
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0417 0.0818 0.0815
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0011 0.0009
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0173 0.0386
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0189 0.0345 0.0343
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0152 0.0267 0.1359
Brugia malayi hypothetical protein 0.029 0.0554 0.0551
Toxoplasma gondii hypothetical protein 0.011 0.018 0.2088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0373 0.0728 0.0725
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0189 0.0345 0.4175
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0087 0.0133 0.0817
Echinococcus granulosus o acyltransferase membrane bound domain 0.0417 0.0818 0.0815
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0042 0.004 0.0355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0059 0.0057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0373 0.0728 0.0725
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0038 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0373 0.0728 0.0725
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0074 0.0072
Schistosoma mansoni loxhd1 0.0041 0.0038 0.0035
Onchocerca volvulus Huntingtin homolog 0.0128 0.0218 0.1097
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.004 0.0036 0.0017
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Plasmodium vivax SET domain protein, putative 0.0125 0.0211 0.2473
Schistosoma mansoni hypothetical protein 0.0041 0.0038 0.0035
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0285 0.0545 0.277
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0147 0.0257 0.0611
Echinococcus granulosus dnaJ subfamily B 0.1268 0.2586 0.2584
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0042 0.004 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0059 0.0057
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0008 0.0039
Schistosoma mansoni hypothetical protein 0.0417 0.0818 0.0815

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3548 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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